CERUS CORP
S-3MEF, 1999-03-31
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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<PAGE>   1
 
     AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON MARCH 31, 1999
 
                                                 REGISTRATION NO. 333-
- --------------------------------------------------------------------------------
- --------------------------------------------------------------------------------
 
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549
                            ------------------------
 
                                    FORM S-3
                             REGISTRATION STATEMENT
                                     UNDER
                           THE SECURITIES ACT OF 1933
                            ------------------------
 
                               CERUS CORPORATION
             (EXACT NAME OF REGISTRANT AS SPECIFIED IN ITS CHARTER)
 
<TABLE>
<S>                                              <C>
                    DELAWARE                                        68-0262011
            (STATE OF INCORPORATION)                   (I.R.S. EMPLOYER IDENTIFICATION NO.)
</TABLE>
 
                         2525 STANWELL DRIVE, SUITE 300
                               CONCORD, CA 94520
                                 (925) 603-9071
   (ADDRESS, INCLUDING ZIP CODE, AND TELEPHONE NUMBER, INCLUDING AREA CODE OF
                   REGISTRANT'S PRINCIPAL EXECUTIVE OFFICES)
                            ------------------------
 
                               STEPHEN T. ISAACS
                     PRESIDENT AND CHIEF EXECUTIVE OFFICER
                               CERUS CORPORATION
                         2525 STANWELL DRIVE, SUITE 300
                               CONCORD, CA 94520
                                 (925) 603-9071
 (NAME, ADDRESS, INCLUDING ZIP CODE, AND TELEPHONE NUMBER, INCLUDING AREA CODE,
                             OF AGENT FOR SERVICE)
                            ------------------------
 
                                   COPIES TO:
 
<TABLE>
<S>                                              <C>
            ALAN C. MENDELSON, ESQ.                            DAVID J. SEGRE, ESQ.
             HOWARD G. ERVIN, ESQ.                       WILSON SONSINI GOODRICH & ROSATI
              ANDREA VACHSS, ESQ.                            PROFESSIONAL CORPORATION
               COOLEY GODWARD LLP                               650 PAGE MILL ROAD
         ONE MARITIME PLAZA, 20TH FLOOR                        PALO ALTO, CA 94306
            SAN FRANCISCO, CA 94111                               (650) 493-9300
                 (415) 693-2000
</TABLE>
 
        Approximate date of commencement of proposed sale to the public:
AS SOON AS PRACTICABLE AFTER THE EFFECTIVE DATE OF THIS REGISTRATION STATEMENT.
 
        If this form is filed to register additional securities for an offering
pursuant to Rule 462(b) under the Securities Act, please check the following box
and list the Securities Act registration statement number of the earlier
effective registration statement for the same offering.  [X]  333-72185
 
                        CALCULATION OF REGISTRATION FEE
 
<TABLE>
<S>                        <C>                     <C>                     <C>                     <C>
- -------------------------------------------------------------------------------------------------------------------------
- -------------------------------------------------------------------------------------------------------------------------
TITLE OF CLASS OF                                     PROPOSED MAXIMUM        PROPOSED MAXIMUM
SECURITIES TO BE                AMOUNT TO BE              OFFERING               AGGREGATE               AMOUNT OF
REGISTERED                     REGISTERED(1)          PRICE PER SHARE        OFFERING PRICE(2)      REGISTRATION FEE(2)
- -------------------------------------------------------------------------------------------------------------------------
Common Stock, par value
  $.001 per share........         230,000                  $21.00                $4,830,000                $1,343
- -------------------------------------------------------------------------------------------------------------------------
</TABLE>
 
(1) Includes 30,000 shares of Common Stock issuable upon exercise of the
    underwriters' over-allotment option.
 
(2) Calculated in accordance with Rule 457(c) of the Securities Act of 1933, as
    amended, based on the public offering price of $21.00 per share.
 
        THIS REGISTRATION STATEMENT SHALL HEREAFTER BECOME EFFECTIVE IN
ACCORDANCE WITH SECTION 8(A) OF THE SECURITIES ACT OF 1933, AS AMENDED, ON SUCH
DATE AS THE COMMISSION, ACTING PURSUANT TO SAID SECTION 8(A), MAY DETERMINE.
- --------------------------------------------------------------------------------
- --------------------------------------------------------------------------------
<PAGE>   2
 
                                EXPLANATORY NOTE
 
        This registration statement is being filed pursuant to Rule 462(b) and
General Instruction IV of Form S-3. Incorporated by reference herein is, in its
entirety, the Registration Statement on Form S-3 (File No. 333-72185) of Cerus
Corporation, as amended, which was declared effective by the Securities and
Exchange Commission on March 31, 1999.
<PAGE>   3
 
                                   SIGNATURES
 
        Pursuant to the requirements of the Securities Act of 1933, as amended,
the Registrant certifies that it has reasonable grounds to believe that it meets
all of the requirements for filing on Form S-3 and has duly caused this
Registration Statement to be signed on its behalf by the undersigned, thereunto
duly authorized, in the City of Concord, State of California, on the 31st day of
March, 1999.
 
                                          CERUS CORPORATION
 
   
                                          By:     /s/ STEPHEN T. ISAACS
    
 
                                            ------------------------------------
                                            Stephen T. Isaacs
                                            President and Chief Executive
                                              Officer
 
        Pursuant to the requirements of the Securities Act of 1933, this
Registration Statement has been signed below by the following persons in the
capacities and on the dates indicated.
 
   
<TABLE>
<CAPTION>
                      SIGNATURE                                     TITLE                    DATE
                      ---------                                     -----                    ----
<C>                                                    <S>                              <C>
                /s/ STEPHEN T. ISAACS                  President, Chief Executive       March 31, 1999
- -----------------------------------------------------  Officer and Director (Principal
                  Stephen T. Isaacs                    Executive Officer)
 
                          *                            Chief Financial Officer and      March 31, 1999
- -----------------------------------------------------  Vice President, Finance
                  Robert E. Miller                     (Principal Financial and
                                                       Accounting)
 
                          *                            Director                         March 31, 1999
- -----------------------------------------------------
                     B.J. Cassin
 
                          *                            Director                         March 31, 1999
- -----------------------------------------------------
                   John E. Hearst
 
                          *                            Director                         March 31, 1999
- -----------------------------------------------------
                  Peter H. McNerney
 
                          *                            Director                         March 31, 1999
- -----------------------------------------------------
                    Dale A. Smith
 
                          *                            Director                         March 31, 1999
- -----------------------------------------------------
                  Henry E. Stickney
 
             *By: /s/ STEPHEN T. ISAACS
  ------------------------------------------------
                  Stephen T. Isaacs
                  Attorney-in-fact
</TABLE>
    
<PAGE>   4
 
                                 EXHIBIT INDEX
 
<TABLE>
<CAPTION>
EXHIBIT
NUMBER                            DESCRIPTION
- -------                           -----------
<S>       <C>
  5.1     Opinion of Cooley Godward LLP.
 23.1     Consent of Ernst & Young LLP, Independent Auditors.
 23.2     Consent of Cooley Godward LLP (Reference is made to Exhibit
          5.1).
</TABLE>

<PAGE>   1
 
                                                                     EXHIBIT 5.1
 
                          [COOLEY GODWARD LETTERHEAD]
 
March 31, 1999
 
Cerus Corporation
2525 Stanwell Drive, Suite 300
Concord, CA 94520
 
Ladies and Gentlemen:
 
        You have requested our opinion with respect to certain matters in
connection with the filing by Cerus Corporation, a Delaware corporation (the
"Company"), of a Registration Statement on Form S-3 (the "Registration
Statement") with the Securities and Exchange Commission (the "Commission") on
March 31, 1999 covering the offering of up to an additional 230,000 shares of
the Company's common stock with a par value of $0.01 (including 30,000 shares of
common stock for which the underwriters will be granted an over-allotment
option) (the "Shares").
 
        In connection with this opinion, we have examined and relied upon the
Registration Statement and related Prospectus included therein, the Company's
Restated Certificate of Incorporation and Bylaws, and the originals or copies
certified to our satisfaction of such records, documents, certificates,
memoranda and other instruments as in our judgment are necessary or appropriate
to enable us to render the opinion expressed below. We have assumed the
genuineness and authenticity of all documents submitted to us as originals, and
the conformity to originals of all documents where due execution and delivery
are a prerequisite to the effectiveness thereof.
 
        On the basis of the foregoing, and in reliance thereon, we are of the
opinion that the Shares, when sold in accordance with the Registration
Statement, will be validly issued, fully paid and nonassessable.
 
        We consent to the reference to our firm under the caption "Legal
Matters" in the Prospectus included in the Registration Statement and to the
filing of this opinion as an exhibit to the Registration Statement.
 
                                          Very truly yours,
 
                                          COOLEY GODWARD LLP
 
   
                                          By: /s/ HOWARD G. ERVIN
    
 
                                            ------------------------------------
                                            Howard G. Ervin

<PAGE>   1
                                                                    EXHIBIT 23.1


               CONSENT OF ERNST & YOUNG LLP, INDEPENDENT AUDITORS

We consent to the incorporation by reference in this Registration Statement 
(Form S-3) of Cerus Corporation for the registration of shares of its common 
stock and to the reference to our firm under the caption "Experts" included in 
the Registration Statement on Form S-3 (No. 333-72185) and to the use of our 
report dated January 22, 1999, except for Note 2 as to which the date is 
January 30, 1999 and Note 5, as to which the date is March 3, 1999, with 
respect to the financial statements of Cerus Corporation, included and 
incorporated by reference in the Registration Statement on Form S-3 (No. 
333-72185).

                                       /s/ Ernst & Young LLP
                                       -----------------------------

Walnut Creek, California
March 29, 1999


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