ORAPHARMA INC
SC 13G, EX-2.1, 2000-12-14
PHARMACEUTICAL PREPARATIONS
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                                                                    Exhibit 2.1
                                                                    ----------

                           Statement of Control Person


The Statement on Schedule 13G dated December 14, 2000 with respect to the common
stock par value $0.001 per share of Orapharma, Inc.is filed by Samuel D. Isaly
in accordance with the provisions of Rule 13d-1(c) and Rule 13d-1(k)
respectively as a control person (HC) of Orbimed Advisors, LLC and Orbimed
Advisors, Inc.

Orbimed Advisors, Inc. files this statement on Schedule 13G in accordance with
the provisions of Rule 13d-1(b) and Rule 13d-1(k) respectively as an investment
advisor (IA) and Orbimed Advisors, LLC files this statement on Schedule 13G in
accordance with the provisions of Rule 13d-1(c) and 13d-1(k) respectively as a
corporation (CO).



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