Exhibit 1.1
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JOINT FILING AGREEMENT
The undersigned hereby agree that the Statement on Schedule 13G, dated December
14, 2000, (the "Schedule 13G"), with respect to the Common Stock, par value
$0.001 per share, of Orapharma, Inc.is, and any amendments thereto executed by
each of us shall be, filed on behalf of each of us pursuant to and in accordance
with the provisions of Rule 13d-1(k) under the Securities and Exchange Act of
1934, as amended, and that this Agreement shall be included as an Exhibit to the
Schedule 13G and each such amendment. Each of the undersigned agrees to be
responsible for the timely filing of the Schedule 13G and any amendments
thereto, and for the completeness and accuracy of the information concerning
itself contained therein. This Agreement may be executed in any number of
counterparts, all of which taken together shall constitute one and the same
instrument.
IN WITNESS WHEREOF, the undersigned have executed this Agreement as of
the 14th day of December, 2000.
OrbiMed Advisers Inc.
By: /s/ Samuel D. Isaly
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Name: Samuel D. Isaly
Title: President
OrbiMed Advisors LLC
By: /s/ Samuel D. Isaly
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Name: Samuel D. Isaly
Title: Managing Member
