<PAGE> 1
SIGNAL PHARMACEUTICALS
5555 OBERLIN DRIVE
SAN DIEGO, CA 92121
September 25, 1998
VIA EDGAR TRANSMISSION
Securities and Exchange Commission
450 Fifth Street, N.W.
Judiciary Plaza
Washington, DC 20549
RE: SIGNAL PHARMACEUTICALS, INC. ("SIGNAL")
REGISTRATION STATEMENT ON FORM S-1 (NO. 333-52901)
APPLICATION FOR WITHDRAWAL
Ladies and Gentlemen:
The undersigned registrant hereby makes application, pursuant to paragraph (a)
of Rule 477 under the Securities Act of 1933, as amended, to withdraw the
above-referenced Registration Statement. This application is made on the grounds
that, based on current market conditions, the undersigned registrant has
determined that it is not advisable at this time to proceed with the proposed
offering.
If you should have any questions regarding this application, please contact
Frederick T. Muto or Michael A. Newman of Cooley Godward LLP at (619) 550-6000.
Sincerely,
SIGNAL PHARMACEUTICALS, INC.
By /s/ Alan J. Lewis
Alan J. Lewis
President and Chief Executive
Officer
cc: Mr. Bradley B. Gordon
Frederick T. Muto, Esq.
Michael A. Newman, Esq.