UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
Form 13F
Form 13F COVER PAGE
Report for the Calendar Year or Quarter Ended: December 31, 1999
Check here if Amendment [ ]; Amendment Number:
------------
This Amendment (Check only one.): [ ] is a restatement.
[ ] adds new holdings entries.
Institutional Investment Manager Filing this Report:
Name: OrbiMed Advisers Inc.
Address: 767 Third Avenue, 6th Floor
New York, NY 10010
Form 13F File Number: 28-6776
The institutional investment manager filing this report and the person by whom
it is signed hereby represent that the person signing the report is authorized
to submit it, that all information contained herein is true, correct and
complete, and that it is understood that all required items, statements,
schedules, lists, and tables, are considered integral parts of this form.
Person Signing this Report on Behalf of Reporting Manager:
Name: Samuel D. Isaly
Title: President
Phone: (212) 739-6400
Signature, Place, and Date of Signing:
/s/ Samuel D. Isaly New York, NY February 15, 2000
[Signature] [City, State] [Date]
Report Type (Check only one.):
[X] 13F HOLDINGS REPORT. (Check here if all holdings of this reporting manager
are reported in this report.)
[ ] 13F NOTICE. (Check here if no holdings reported are in this report, and all
holdings are reported by other reporting manager(s).)
[ ] 13F COMBINATION REPORT. (Check here if a portion of the holdings for this
reporting manager are reported in this report and a portion are reported by
other reporting manager(s).)
<PAGE>
Form 13F SUMMARY PAGE
Report Summary:
Number of Other Included Managers: 1
Form 13F Information Table Entry Total: 61
Form 13F Information Table Value Total: $458,081
(thousands)
List of Other Included Managers:
Provide a numbered list of the name(s) and Form 13F file number(s) of all
institutional investment managers with respect to which this report is filed,
other than the manager filing this report.
[If there are no entries in this list, state "NONE" and omit the column headings
and list entries.]
No. Form 13F File Number Name
2 28-6774 OrbiMed Advisors LLC
<PAGE>
Form 13F INFORMATION TABLE
Quarter Ended December 31, 1999
Manager Key: (1) OrbiMed Advisers Inc.
(2) OrbiMed Advisors LLC
<TABLE>
<CAPTION>
Column 1 Column 2 Column 3 Column 4 Column 5 Column 6 Column 7 Column 8
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Investment Discretion Voting Authority
(Shares)
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Name of Issuer Title of CUSIP Number Market Value SHRS Sole Shared Shared Other Sole Shared None
Class Defined Other Managers
- ------------------------------------------------------------------------------------------------------------------------------------
<S> <C> <C> <C> <C> <C> <C> <C>
Abgenix, Inc COM 00339B107 20,670,000 156,000 X 1 156,000
Abgenix, Inc COM 00339B107 28,620,000 216,000 X 2 216,000
Affymetrix Inc. COM 00826T108 1,187,813 7,000 X 1 7,000
Affymetrix Inc. COM 00826T108 4,411,875 26,000 X 2 26,000
Alexion Pharmaceuticals, COM 015351109 8,133,750 270,000 X 1 270,000
Inc.
Alexion Pharmaceuticals, COM 015351109 13,270,063 440,500 X 2 440,500
Inc.
Alza Corp. COM 22615108 6,405,625 185,000 X 1 185,000
Alza Corp. COM 22615108 10,318,250 298,000 X 2 298,000
American Home Products COM 26609107 1,256,000 32,000 X 1 32,000
American Home Products COM 26609107 3,532,500 90,000 X 2 90,000
Aquila COM 03839f107 1,242,125 523,000 X 2 523,000
Biopharmaceuticals
Aradigm Corp COM 38505103 1,978,850 208,300 X 2 208,300
Aviron COM 053762100 4,308,906 250,000 X 1 250,000
Aviron COM 053762100 4,182,406 264,500 X 2 264,500
BioChem Pharma Inc. COM 09058T108 652,500 30,000 X 1 30,000
BioChem Pharma Inc. COM 09058T108 3,045,000 140,000 X 2 140,000
Bio-Technology General COM 090578105 6,530,050 428,200 X 1 428,200
Bio-Technology General COM 090578105 5,429,000 356,000 X 2 356,000
Caliper Technologies COM 130876105 1,335,000 20,000 X 1 20,000
Caliper Technologies COM 130876105 26,029,718 389,958 X 2 389,958
Cell Genesys Inc. COM 150921104 896,875 70,000 X 1 70,000
Cell Genesys Inc. COM 150921104 691,875 54,000 X 2 54,000
Cell Therapeutics COM 150934107 3,236,996 462,428 X 2 462,428
Chiron Corp. COM 170040109 5,593,500 132,000 X 1 132,000
Chiron Corp. COM 170040109 5,000,250 118,000 X 2 118,000
Coulter Pharmaceutical COM 222116105 739,613 32,600 X 1 32,600
Inc.
</TABLE>
<PAGE>
<TABLE>
<CAPTION>
Column 1 Column 2 Column 3 Column 4 Column 5 Column 6 Column 7 Column 8
- ------------------------------------------------------------------------------------------------------------------------------------
Investment Discretion Voting Authority
(Shares)
- ------------------------------------------------------------------------------------------------------------------------------------
Name of Issuer Title of CUSIP Number Market Value SHRS Sole Shared Shared Other Sole Shared None
Class Defined Other Managers
- ------------------------------------------------------------------------------------------------------------------------------------
<S> <C> <C> <C> <C> <C> <C> <C>
Coulter Pharmaceutical COM 222116105 2,835,938 125,000 X 2 125,000
Inc.
Discovery Laboratories COM 254668106 4,728,005 1,699,957 X 2 1,699,957
Inc.
Eli Lilly & Company COM 532457108 11,039,000 166,000 X 1 166,000
Eli Lilly & Company COM 532457108 16,359,000 246,000 X 2 246,000
Enzon Inc. COM 293904108 650,625 15,000 X 1 15,000
Enzon Inc. COM 293904108 5,205,000 120,000 X 2 120,000
Forest Laboratories - CL COM 345838106 10,321,500 168,000 X 1 168,000
A
Forest Laboratories - CL COM 345838106 12,656,125 206,000 X 2 206,000
A
Geltex Pharmaceuticals COM 368538104 6,201,250 484,000 X 1 484,000
Inc.
Geltex Pharmaceuticals COM 368538104 9,865,625 770,000 X 2 770,000
Inc.
Genta Inc. COM 37245M207 1,287,500 200,000 X 2 200,000
Genzyme Corp. General COM 372917104 10,440,000 232,000 X 1 232,000
Division
Genzyme Corp. General COM 372917104 15,930,000 354,000 X 2 354,000
Division
Gilead Sciences Inc. COM 375558103 6,711,500 124,000 X 1 124,000
Gilead Sciences Inc. COM 375558103 11,474,500 212,000 X 2 212,000
Ilex Oncology Inc. COM 451923106 1,025,313 42,500 X 1 42,500
Incyte Pharmaceuticals COM 45337C102 1,020,000 17,000 X 1 17,000
Inc.
Incyte Pharmaceuticals COM 45337C102 1,500,000 25,000 X 2 25,000
Inc.
Maxim Pharmaceuticals COM 57772M107 5,602,220 280,111 X 1 280,111
Monsanto COM 611662107 10,687,500 300,000 X 1 300,000
Monsanto COM 611662107 17,812,500 500,000 X 2 500,000
PathoGenesis Corp. COM 70321E104 1,794,319 83,700 X 2 83,700
Pharmacia and Upjohn COM 716941109 5,400,000 120,000 X 1 120,000
Inc.
Pharmacia and Upjohn COM 716941109 11,250,000 250,000 X 2 250,000
Inc.
Pharmacopeia Inc. COM 71713B104 9,482,138 419,100 X 1 419,100
Pharmacopeia Inc. COM 71713B104 9,559,063 422,500 X 2 422,500
Premier Research COM 740568100 2,943,750 300,000 X 1 300,000
Worldwide
SangStat Medical Corp. COM 801003104 8,925,000 300,000 X 1 300,000
SangStat Medical Corp. COM 801003104 12,605,075 423,700 X 2 423,700
Tularik Inc. COM 899165104 8,093,750 250,000 X 1 250,000
Tularik Inc. COM 899165104 3,237,500 100,000 X 2 100,000
Vertex Pharmaceuticals COM 92532F100 9,100,000 260,000 X 1 260,000
Inc.
</TABLE>
<PAGE>
<TABLE>
<CAPTION>
Column 1 Column 2 Column 3 Column 4 Column 5 Column 6 Column 7 Column 8
- ------------------------------------------------------------------------------------------------------------------------------------
Investment Discretion Voting Authority
(Shares)
- ------------------------------------------------------------------------------------------------------------------------------------
Name of Issuer Title of CUSIP Number Market Value SHRS Sole Shared Shared Other Sole Shared None
Class Defined Other Managers
- ------------------------------------------------------------------------------------------------------------------------------------
<S> <C> <C> <C> <C> <C> <C> <C>
Vertex Pharmaceuticals COM 92532F100 13,300,000 380,000 X 2 380,000
Inc.
Warner-Lambert Co. COM 934488107 11,575,229 141,269 X 1 141,269
Warner-Lambert Co. COM 934488107 18,763,688 229,000 X 2 229,000
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Total 458,081,153 15,165,323 15,165,323
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</TABLE>
