UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
Form 13F
Form 13F COVER PAGE
Report for the Calendar Year or Quarter Ended: September 30, 2000
Check here if Amendment: |_|; Amendment Number: ____
This Amendment (Check only one): |_| is a restatement.
|_| adds new holdings
entries.
Institutional Investment Manager Filing this Report:
Name: OrbiMed Advisers Inc.
Address: 767 Third Avenue, 6th Floor
New York, NY 10010
Form 13F File Number: 28-6776
The institutional investment manager filing this report and the person by whom
it is signed hereby represent that the person signing the report is authorized
to submit it, that all information contained herein is true, correct and
complete, and that it is understood that all required items, statements,
schedules, lists, and tables, are considered integral parts of this form.
Person Signing this Report on Behalf of Reporting Manager:
Name: Samuel D. Isaly
Title: President
Phone: (212) 739-6400
Signature, Place, and Date of Signing:
Samuel D. Isaly New York, NY November 15, 2000
[Signature] [City, State] [Date]
Report Type (Check one only):
[X] 13F HOLDINGS REPORT. (Check here if all holdings of this reporting manager
are reported in this report.)
[ ] 13F NOTICE. (Check here if no holdings reported are in this report, and
all holdings are reported by other reporting manager(s).)
[ ] 13F COMBINATION REPORT. (Check here if a portion of the holdings for this
reporting manager are reported in this report and a portion are reported by
other reporting manager(s).)
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Form 13F SUMMARY PAGE
Report Summary:
Number of Other Included Managers: 1
Form 13F Information Table Entry Total: 81
Form 13F Information Table Value Total: $1,679,918,987
List of Other Included Managers:
Provide a numbered list of the name(s) and Form 13F file member(s) of all
institutional investment managers with respect to which this report is filed,
other than the manager filing this report.
[If there are no entries in this list, state "NONE" and omit the column headings
and list entries.]
No. Form 13F File Number Name
2 28-6774 OrbiMed Advisors LLC
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FORM 13F INFORMATION TABLE
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Column 1 Column 2 Column 3 Column 4 Column 5 Column 6 Column 7 Column 8
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Investment Discretion Voting Authority
(Shares)
Title Shared Shared Other Shared
Name of Issuer of Class CUSIP Number Market Value SHRS Sole Defined Other Managers Sole None
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<S> <C> <C> <C> <C> <C> <C> <C>
Abbott Laboratories COM 2824100 48,157,031 1,012,500 X 1,012,500
Abbott Laboratories COM 2824100 14,411,437 303,000 X 2 303,000
Abgenix, Inc COM 00339B107 38,014,200 470,400 X 470,400
Abgenix, Inc COM 00339B107 30,967,350 383,200 X 2 383,200
Acacia Research Corp. COM 3881109 3,107,362 89,100 X 89,100
Acacia Research Corp. COM 3881109 3,055,050 87,600 X 2 87,600
Alexion Pharmaceuticals, Inc. COM 015351109 23,940,000 210,000 X 210,000
Alexion Pharmaceuticals, Inc. COM 015351109 23,997,000 210,500 X 2 210,500
Alza Corp. COM 22615108 42,160,100 487,400 X 487,400
Alza Corp. COM 22615108 11,677,500 135,000 X 2 135,000
American Home Products COM 26609107 44,754,937 793,000 X 793,000
American Home Products COM 26609107 42,892,500 760,000 X 2 760,000
Amgen Inc. COM 31162100 7,401,781 106,000 X 106,000
Amgen Inc. COM 31162100 17,596,687 252,000 X 2 252,000
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<S> <C> <C> <C> <C> <C> <C> <C>
Arena Pharma. COM 40047102 35,776,774 832,018 X 832,018
Argonaut Technologies Inc. COM 40175101 2,320,312 125,000 X 125,000
Arqule Inc. COM 04269E107 6,842,062 401,000 X 401,000
Arqule Inc. COM 04269E107 11,322,675 663,600 X 2 663,600
Aviron COM 053762100 20,222,775 346,800 X 346,800
Aviron COM 053762100 12,624,656 216,500 X 2 216,500
Bio-Technology General COM 090578105 26,906,719 2,352,500 X 2,352,500
Bio-Technology General COM 090578105 19,266,469 1,684,500 X 2 1,684,500
Caliper Technologies COM 130876105 42,728,906 737,500 X 737,500
Caliper Technologies COM 130876105 30,619,930 528,499 X 2 528,499
Cell Therapeutics COM 150934107 1,667,187 25,000 X 25,000
Cell Therapeutics COM 150934107 1,667,187 25,000 X 2 25,000
Chiron Corp. COM 170040109 43,965,000 977,000 X 977,000
Chiron Corp. COM 170040109 21,150,000 470,000 X 2 470,000
COR Therapeutics Inc. COM 217753102 10,717,750 172,000 X 172,000
COR Therapeutics Inc. COM 217753102 13,771,062 221,000 X 2 221,000
Eli Lilly & Company COM 532457108 53,542,500 660,000 X 660,000
Eli Lilly & Company COM 532457108 40,968,125 505,000 X 2 505,000
Enchira Biotech. COM 29251Q107 5,119,687 635,000 X 635,000
Enchira Biotech. COM 29251Q107 4,998,750 620,000 X 2 620,000
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<S> <C> <C> <C> <C> <C> <C> <C>
Enzon Inc. COM 293904108 32,406,000 491,000 X 491,000
Enzon Inc. COM 293904108 18,744,000 284,000 X 2 284,000
Forest Laboratories - CL A COM 345838106 26,401,062 230,200 X 230,200
Forest Laboratories - CL A COM 345838106 28,901,250 252,000 X 2 252,000
Geltex Pharmaceuticals Inc. COM 368538104 39,963,831 853,700 X 853,700
Geltex Pharmaceuticals Inc. COM 368538104 33,770,537 721,400 X 2 721,400
Genaissance Pharm Inc. COM 36867W105 4,880,181 235,900 X 235,900
Genaissance Pharm Inc. COM 36867W105 1,452,262 70,200 X 2 70,200
Genzyme Corp. General Division COM 372917104 45,753,812 671,000 X 671,000
Genzyme Corp. General Division COM 372917104 31,025,312 455,000 X 2 455,000
Gilead Sciences Inc. COM 375558103 35,538,750 324,000 X 324,000
Gilead Sciences Inc. COM 375558103 31,260,937 285,000 X 2 285,000
Incyte Pharma COM 45337C102 5,305,125 129,000 X 129,000
Incyte Pharma COM 45337C102 5,177,637 125,900 X 2 125,900
Insmed Incorporated COM 457669208 1,394,103 105,714 X 105,714
Insmed Incorporated COM 457669208 2,373,757 180,000 X 2 180,000
IntraBiotics COM 46116T100 2,708,339 166,667 X 166,667
Molecular Devices Corp COM 60851C107 15,014,565 152,820 X 152,820
Molecular Devices Corp COM 60851C107 4,716,000 448,000 X 2 448,000
Neopharm COM 640919106 4,187,000 106,000 X 106,000
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<S> <C> <C> <C> <C> <C> <C> <C>
Neopharm COM 640919106 4,384,500 111,000 X 2 111,000
Orapharma Inc. COM 68554E106 8,062,500 600,000 X 600,000
Orchid Biosciences COM 68571P100 37,663,466 1,107,749 X 1,107,749
Orchid Biosciences COM 68571P100 46,970,320 1,381,480 X 2 1,381,480
Orphan Medical, Inc. COM 687303107 8,476,875 685,000 X 685,000
Orphan Medical, Inc. COM 687303107 7,177,500 580,000 X 2 580,000
PE Corp - Celera COM 69332S201 28,393,125 285,000 X 285,000
PE Corp - Celera COM 69332S201 13,847,875 139,000 X 2 139,000
Pfizer Inc. COM 717081103 61,182,406 1,361,500 X 1,361,500
Pfizer Inc. COM 717081103 67,765,750 1,508,000 X 2 1,508,000
Pharmacia Corp. COM 71713U102 54,830,812 911,000 X 911,000
Pharmacia Corp. COM 71713U102 46,555,031 773,500 X 2 773,500
Pharmacopeia Inc. COM 71713B104 23,383,500 917,000 X 917,000
Pharmacopeia Inc. COM 71713B104 9,830,250 385,500 X 2 385,500
Praecis Pharmaceutical, Inc. COM 739421105 14,913,250 350,900 X 350,900
Praecis Pharmaceutical, Inc. COM 739421105 29,447,506 692,882 X 2 692,882
Repligen Corp. COM 759916109 1,261,125 177,000 X 177,000
Repligen Corp. COM 759916109 1,332,375 187,000 X 2 187,000
SangStat Medical Corp. COM 801003104 11,100,750 866,400 X 866,400
SangStat Medical Corp. COM 801003104 10,398,625 811,600 X 2 811,600
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<CAPTION>
<S> <C> <C> <C> <C> <C> <C> <C>
Sepracor Inc. COM 817315104 3,827,850 31,200 X 31,200
Sepracor Inc. COM 817315104 3,533,400 28,800 X 2 28,800
Telik Inc. COM 87959M109 2,321,400 254,400 X 254,400
Telik Inc. COM 87959M109 666,125 73,000 X 2 73,000
Transgenomic Inc. COM 89365K206 2,268,750 100,000 X 100,000
Tularik Inc. COM 899165104 28,908,000 876,000 X 876,000
Tularik Inc. COM 899165104 22,110,000 670,000 X 2 670,000
Total 81 1,679,918,987 39,650,029 39,650,029
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