ADOLOR CORP
S-8, 2000-12-04
PHARMACEUTICAL PREPARATIONS
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     As filed with the Securities and Exchange Commission on December 4, 2000.
                                                 Registration No. 33-

================================================================================
                       SECURITIES AND EXCHANGE COMMISSION
                              Washington, DC 20549

                                    FORM S-8

                             REGISTRATION STATEMENT
                                     UNDER
                           THE SECURITIES ACT OF 1933

                               ADOLOR CORPORATION
             (Exact name of Registrant as specified in its charter)

       Delaware                620 Pennsylvania Drive             31-1429198
(State of Incorporation)    Exton, Pennsylvania 19341       (I.R.S. Employer
                             (Address of principal           Identification No.)
                           executive offices) (Zip Code)

                    ADOLOR CORPORATION AMENDED AND RESTATED
                         1994 EQUITY COMPENSATION PLAN
                            (Full Title of the Plan)

                             John J. Farrar, Ph.D.
                     President and Chief Executive Officer
                               Adolor Corporation
                             620 Pennsylvania Drive
                          Exton, Pennsylvania 19341

                    (name and address of agent for service)

                                 (484) 595-1500
         (Telephone number, including area code, of agent for service)

                        Copies of all communications to:

                           James A. Lebovitz, Esquire
                                    Dechert
                            4000 Bell Atlantic Tower
                                1717 Arch Street
                     Philadelphia, Pennsylvania 19103-2793
                                 (215) 994-4000

                        CALCULATION OF REGISTRATION FEE



<TABLE>

<S>                 <C>             <C>          <C>          <C>
                                    Proposed     Proposed
Title of            Amount          maximum      maximum      Amount of
securities          to be           offering     aggregate    registration
to be               registered      price per    offering     fee
registered                          share(1)     price(1)
-----------------   -------------   ----------   ----------   -------------
Common Stock        2,440,015
par value $.0001    shares          $19.13       $46,677,487   $12,323
per share

</TABLE>

(1)  The  amounts  are  based  upon the  average  of the high and low sale
     prices for the Common Stock as reported on the Nasdaq National Market
     on  November  30,  2000,  and are  used  solely  for the  purpose  of
     calculating  the  registration  fee in accordance with paragraphs (c)
     and (h) of Rule 457 under the Securities Act of 1933


<PAGE>


                                     PART I

                INFORMATION REQUIRED IN SECTION 10(a) PROSPECTUS

The documents containing information specified in Part I of Form S-8 will be
sent or given to employees eligible to participate in the Adolor Corporation
Amended and Restated 1994 Equity  Compensation Plan (the "Plan") as specified by
Rule 428(b)(1) of the Securities Act of 1933, as amended (the "Securities Act").
Those   documents  and  the  documents   incorporated  by  reference  into  this
Registration  Statement  pursuant  to Item 3 of  Part  II of  this  Registration
Statement,  taken together,  constitute a prospectus that meets the requirements
of Section 10(a) of the Securities Act.

                                     PART II

               INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

Item 3.  Incorporation of Documents by Reference.

The following  documents of Adolor Corporation (the "Registrant") filed or to be
filed with the Securities and Exchange  Commission (the "SEC") are  incorporated
by reference in this Registration Statement as of their respective dates:

     (a) The  Registrant's  prospectus  filed with the SEC on November  15, 2000
pursuant to Rule 424(b) under the Securities Act that contains audited financial
statements for its latest fiscal year ended December 31, 1999;

     (b) All other reports filed with the SEC pursuant to Section 13(a) or 15(d)
of the Securities Exchange Act of 1934 since December 31, 1999;

     (c) The  description  of the  Registrant's  Common  Stock  contained in its
registration  statement on Form 8-A (File No. 000-30039),  filed March 21, 2000,
which  incorporates  by reference the section  entitled  "Description of Capital
Stock" in its  registration  statement on Form S-1 (File No.  333-96333),  filed
February 8, 2000,  as amended from time to time,  and including any amendment or
report filed for the purpose of updating such description; and

     (d) All  documents  subsequently  filed with the SEC  pursuant  to Sections
13(a),  13(c), 14 and 15(d) of the Securities Exchange Act of 1934, but prior to
the  filing  with the SEC of a  post-effective  amendment  to this  registration
statement  that  indicates  that all shares of Common Stock  registered  on this
registration  statement have been sold or deregisters the balance of such shares
then remaining  unsold,  shall be deemed to be incorporated in this registration
statement by reference and to be a part of this registration  statement from the
date of filing of such documents.

Item 4.  Description of Securities.

Not applicable.


<PAGE>

Item 5.  Interests of Named Experts and Counsel.

The validity of the Registrant's Common Stock offered hereby will be passed upon
by the Dechert law firm of Philadelphia, Pennsylvania. Dechert beneficially owns
40,000  shares of the  Registrant's  Common  Stock.  Attorneys  associated  with
Dechert who provided legal advice in connection with this offering  beneficially
own an aggregate of 15,866 shares of the Registrant's Common Stock.

Item 6.  Indemnification of Directors and Officers.

Under Section 145 of the General Corporate Law of the State of Delaware,  Adolor
Corporation  has broad powers to indemnify its  directors  and officers  against
liabilities they may incur in such capacities,  including  liabilities under the
Securities  Act.  Adolor   Corporation's   bylaws  also  provide  for  mandatory
indemnification  of  its  directors  and  executive  officers,   and  permissive
indemnification  of its employees and agents, to the fullest extent  permissible
under Delaware law. Adolor Corporation's  certificate of incorporation  provides
that the liability of its directors for monetary  damages shall be eliminated to
the fullest extent  permissible  under  Delaware law.  Pursuant to Delaware law,
this includes  elimination  of liability for monetary  damages for breach of the
directors'  fiduciary duty of care to Adolor  Corporation and its  stockholders.
These  provisions  do  not  eliminate  the  directors'  duty  of  care  and,  in
appropriate circumstances,  equitable remedies such as injunctive or other forms
of  non-monetary  relief will remain  available under Delaware law. In addition,
each  director  will  continue  to be  subject  to  liability  for breach of the
director's duty of loyalty to Adolor  Corporation,  for acts or omissions not in
good faith or involving intentional  misconduct,  for knowing violations of law,
for any  transaction  from  which the  director  derived  an  improper  personal
benefit,  and for  payment of  dividends  or approval  of stock  repurchases  or
redemptions  that are unlawful  under  Delaware law. The provision also does not
affect a director's  responsibilities  under any other laws, such as the federal
securities laws or state or federal environmental laws.

Adolor  Corporation has obtained a policy of directors' and officers'  liability
insurance that insures the Company's  directors and officers against the cost of
defense, settlement or payment of a judgment under certain circumstances.

Item 7.  Exemption from Registration Claimed.

Not applicable.


Item 8.  Exhibits.

The following  exhibits are filed herewith and are  incorporated by reference as
part of this Registration Statement:

     4.1    Articles of Incorporation of the Registrant, which are incorporated
            herein by reference to its registration statement on Form S-1 (File
            No. 333-96333), filed with the SEC on October 10, 2000.

                                       2
<PAGE>

     4.2    Bylaws of the Registrant, which are incorporated herein by reference
            to our registration statement on Form S-1 (File No.333-96333), filed
            with the SEC on March 13, 2000.

     5.1    Opinion of Dechert

     23.1   Consent of Independent Auditors

     23.2   Consent of Dechert (contained in the opinion filed as Exhibit 5.1 to
            this Registration Statement).

     24.1   Power of Attorney (set forth on signature page of this Registration
            Statement).

Item 9.  Undertakings.

Undertakings required by Item 512(a)
of Regulation S-K
-------------------------------------

The undersigned Registrant hereby undertakes:

     (1)  To file,  during any  period in which  offers or sales are being made,
a post-effective amendment to this Registration Statement:

          (i)  To include any prospectus required by Section 10(a)(3) of the
     Securities Act of 1933;

          (ii) To reflect in the prospectus any facts or events arising after
     the effective date of the Registration  Statement (or the most recent post-
     effective amendment thereof) which, individually or in the aggregate,
     represent a fundamental change in the information set forth in the
     Registration Statement;

          (iii) To include any material  information with respect to the plan of
     distribution not previously disclosed in the Registration  Statement or any
     material change to such information in the Registration Statement;

provided,  however, that paragraphs (i) and (ii) do not apply if the information
required to be included in a  post-effective  amendment by those  paragraphs  is
contained  in  periodic  reports  filed  with  or  furnished  to the  SEC by the
Registrant  pursuant to Section 13 or 15(d) of the  Securities  Exchange  Act of
1934 that are incorporated by reference in the Registration Statement.

     (2)  That,  for the  purpose  of determining  any liability  under the
Securities Act of 1933,  each such  post-effective  amendment shall be deemed
to be a new registration  statement  relating to the securities offered therein,
and the  offering  of such  securities  at that  time  shall be deemed to be the
initial bona fide offering thereof.

     (3) To remove from  registration by means of a  post-effective amendment
any of the  securities being  registered which  remain unsold at the termination
of the offering.

                                       3
<PAGE>

Undertakings required by Item 512(b)
of Regulation S-K
------------------------------------

The undersigned  Registrant  hereby undertakes that, for purposes of determining
any liability under the Securities Act, each filing of the  Registrant's  annual
report  pursuant to Section  13(a) or 15(d) of the Exchange Act (and each filing
of an employee  benefit  plan's annual  report  pursuant to Section 15(d) of the
Exchange Act) that is  incorporated by reference in the  Registration  Statement
shall be deemed to be a new  registration  statement  relating to the securities
offered therein and the offering of such securities at that time shall be deemed
to be initial bona fide offering thereof.

Undertakings required by Item 512(h)
of Regulation S-K
------------------------------------

Insofar as indemnification  for liabilities  arising under the Securities Act of
1933 may be permitted to  directors,  officers  and  controlling  persons of the
Registrant pursuant to the foregoing  provisions,  or otherwise,  the Registrant
has been advised that in the opinion of the Securities  and Exchange  Commission
such indemnification is against public policy as expressed in the Securities Act
of  1933  and is,  therefore,  unenforceable.  In the  event  that a  claim  for
indemnification  against  such  liabilities  (other  than  the  payment  by  the
Registrant of expenses  incurred or paid by a director,  officer or  controlling
person of the  registrant  in the  successful  defense  of any  action,  suit or
proceeding)  is  asserted by such  director,  officer or  controlling  person in
connection with the securities being registered,  the Registrant will, unless in
the opinion of its counsel the matter has been settled by controlling precedent,
submit  to a  court  of  appropriate  jurisdiction  the  question  whether  such
indemnification  by it is against public policy as expressed in the Act and will
be governed by the final adjudication of such issue.

                                       4
<PAGE>


                                   SIGNATURES

The Registrant.  Pursuant to the requirements of the Securities Act of 1933, the
Registrant certifies that it has reasonable grounds to believe that it meets all
of the requirements for filing on Form S-8 and has duly caused this Registration
Statement  to be  signed  on its  behalf  by  the  undersigned,  thereunto  duly
authorized, in the City of Exton, State of Pennsylvania, on December 4, 2000.

                                            ADOLOR CORPORATION



                                            By:  /s/ John J. Farrar
                                                 -----------------------
                                                 John J. Farrar, Ph.D.
                                                 President, Chief Executive
                                                 Officer and Director
                                                 (Principal Executive Director)


                                            By:  /s/ Peter J. Schied
                                                 -----------------------
                                                 Peter J. Schied
                                                 Vice President, Chief
                                                 Financial Officer and Secretary
                                                 (Principal Financial and
                                                 Accounting Officer)


                               POWER OF ATTORNEY

KNOW ALL MEN BY THESE PRESENTS,  that each person whose signature  appears below
constitutes and appoints John. J. Farrar,  Ph.D. and Peter J. Schied and each of
them,  as such person's true and lawful  attorney-in-fact  and agent,  with full
power of substitution and revocation, for such person and in such person's name,
place  and  stead,  in any and all  capacities,  to sign any and all  amendments
(including post-effective amendments) to this Registration Statement on Form S-8
under  the  Securities  Act of  1933,  and to file the  same  with all  exhibits
thereto,  and other documents in connection  therewith,  with the Securities and
Exchange  Commission,  granting unto said  attorney-in-fact and agent full power
and  authority  to do and  perform  each and every act and thing  requisite  and
necessary  to be done,  as fully as to all intents  and  purposes as such person
might or could do in  person,  hereby  ratifying  and  confirming  all that said
attorney-in-fact and agent or his substitute or substitutes,  may lawfully do or
cause  to be  done  by  virtue  thereof.  Pursuant  to the  requirements  of the
Securities Act of 1933, this  Registration  Statement and the foregoing Power of
Attorney have been signed by the following  persons in the capacities and on the
date indicated.

                                             By: /s/ Frank Baldino, Jr.
                                                 --------------------------
                                                 Frank Baldino, Jr.
                                                 Director
                                                 Date:  December 4, 2000

                                       5
<PAGE>

                                            By:
                                                 ------------------------
                                                 Ellen M. Feeney
                                                 Director



                                            By:  /s/ Paul Goddard
                                                 ------------------------
                                                 Paul Goddard
                                                 Director
                                                 Date:  December 4, 2000


                                            By:  /s/ David M. Madden
                                                 ------------------------
                                                 David M. Madden
                                                 Director
                                                 Date:  December 4, 2000


                                            By:  /s/ C. Christopher Moller
                                                 ------------------------
                                                 C. Christopher Moller
                                                 Director
                                                 Date:  December 4, 2000


                                            By:  /s/ Robert T. Nelsen
                                                 ------------------------
                                                 Robert T. Nelsen
                                                 Director
                                                 Date:  December 3, 2000


                                            By:  /s/ Claude H. Nash
                                                 ------------------------
                                                 Claude H. Nash
                                                 Director
                                                 Date:  December 4, 2000



                                       6

<PAGE>




                                   EXHIBIT INDEX
                                   --------------

Exhibit No.         Document
----------          --------

   4.1              Articles  of  Incorporation  of the  Registrant,  which  are
                    incorporated   herein  by  reference  to  its   registration
                    statement on Form S-1 (File No.  333-96333),  filed with the
                    SEC on October 10, 2000.

   4.2              Bylaws of the Registrant,  which are incorporated  herein by
                    reference  to its  registration  statement on Form S-1 (File
                    No. 333-96333), filed with the SEC on March 13, 2000.

   5.1              Opinion of Dechert

   23.1             Consent of Independent Auditors

   23.2             Consent  of  Dechert  (contained  in the  opinion  filed  as
                    Exhibit 5.1 to this Registration Statement).

   24.1             Power  of  Attorney  (set  forth on  signature  page of this
                    Registration Statement)


                                       7


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