ADOLOR CORP
S-8, EX-5.1, 2000-12-04
PHARMACEUTICAL PREPARATIONS
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                              OPINION RE LEGALITY

December 4, 2000


Adolor Corporation
620 Pennsylvania Drive
Exton, Pennsylvania 19341


Re:  2,440,015 Shares of Common Stock,
     Par Value $.0001 Per Share, of Adolor Corporation
     --------------------------------------------------

Gentlemen and Ladies:

We have acted as  counsel to Adolor  Corporation,  a Delaware  corporation  (the
"Company),  in  connection  with the  issuance by the Company of an aggregate of
2,440,015  shares (the "Shares") of the Company's Common Stock, par value $.0001
per share ("Common  Stock"),  pursuant to a  Registration  Statement on Form S-8
(the  "Registration  Statement")  filed today with the  Securities  and Exchange
Commission under the Securities Act of 1933, as amended (the "Securities  Act"),
relating to the Adolor Corporation Amended and Restated 1994 Equity Compensation
Plan (the "Plan").

We have  participated  in the  preparation  of the  Registration  Statement  and
examined  such  corporate  records and  documents  and matters of law as we have
considered appropriate to render this opinion.

Based upon the foregoing, it is our opinion that:

     (1) the Shares have been duly and validly authorized by the Company; and

     (2) upon  exercise of stock  options and issuance of the Shares  underlying
such stock  options,  in accordance  with the terms of the Plan, and delivery of
such Shares to the  purchasers  thereof  against  payment of the exercise  price
therefor, the Shares will be validly issued, fully paid and nonassessable.

We  hereby  consent  to  the  filing  of  this  opinion  as  Exhibit  5.1 to the
Registration  Statement. In giving such consent, we do not thereby admit that we
are in the category of persons whose consent is required  under Section 7 of the
Securities Act or under the rules and regulations  promulgated by the Securities
and Exchange Commission.

Very truly yours,

DECHERT




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