BIOTECH HOLDRS TRUST
8-K, 2000-03-03
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                       SECURITIES AND EXCHANGE COMMISSION

                             Washington, D.C. 20549

                                 --------------

                                    FORM 8-K

                Current Report Pursuant to Section 13 or 15(d) of
                       The Securities Exchange Act of 1934

       Date of Report (Date of earliest event reported): December 21, 1999

                             Biotech HOLDRsSM Trust
                                Initial Depositor
             (Exact name of registrant as specified in its charter)

                             Biotech HOLDRsSM Trust
                      [Issuer with respect to the receipts]

                                    New York
                 (State or other jurisdiction of incorporation)

                             Commission File Number

                                 Not applicable
                      (I.R.S. Employer Identification No.)

                      c/o The Bank of New York, as Trustee
                            101 Barclay Street, 22-W
                               New York, New York
              (Address of principal executive offices and zip code)

                               Page 1 of 5 pages.
                      The Exhibit Index appears at Page 4.


<PAGE>


Item 5.  Other Events

         On January 20, 2000, Sepracor Inc. declared a two-for-one stock split
on its common stock, to be effected by means of a stock dividend to shareholders
of record on February 1, 2000. The shares of common stock began trading on a
split-adjusted basis on February 28, 2000. The share amount of Sepracor Inc.
represented by a round-lot of 100 Biotech HOLDRs is 6.

         IDEC Pharmaceuticals Corporation effected a two-for-one stock split on
its common stock by means of a stock dividend. The shares of common stock began
trading on a split-adjusted basis on December 21, 1999. The share amount of IDEC
Pharmaceuticals Corporation represented by a round-lot of 100 Biotech HOLDRs is
4.

         On January 5, 2000, Human Genome Sciences, Inc. declared a two-for-one
stock split on its common stock, to be effected by means of a stock dividend to
shareholders of record on January 14, 2000. The shares of common stock began
trading on a split-adjusted basis on January 31, 2000. The share amount of Human
Genome Sciences, Inc. represented by a round-lot of 100 Biotech HOLDRs is 4.

Item 7.  Financial Statements, Pro Forma Financial Information and Exhibits

         (c) Exhibits

               (99) Biotech HOLDRsSM Trust Prospectus Supplement dated January
                    21, 2000 to Prospectus dated November 22, 1999.











                                        2

<PAGE>


                                    SIGNATURE

         Pursuant to the requirements of the Securities Exchange Act of 1934,
the registrant has duly caused this report to be signed on its behalf by the
undersigned hereunto duly authorized.

                              MERRILL LYNCH, PIERCE, FENNER & SMITH INCORPORATED



Date: March 3, 2000           By:  /s/ Stephen G. Bodurtha
                                   ---------------------------
                                   Name:  Stephen G. Bodurtha
                                   Title: Attorney-in-Fact





















                                        3

<PAGE>


                                  EXHIBIT INDEX

Number and Description of Exhibit                            Sequential
- ---------------------------------                            Page Number
                                                             -----------

(99) Biotech HOLDRsSM Trust Prospectus                          Pg. 5
Supplement dated January 21, 1999 to
Prospectus dated November 22, 1999.
























                                        4




PROSPECTUS SUPPLEMENT
(To Prospectus dated November 22, 1999)


                                     [LOGO]
                                 BIOTECH HOLDERs

                        1,000,000,000 Depositary Receipts
                            Biotech HOLDRs(TM) Trust

     This prospectus supplement amends and supplements certain information
contained in the accompanying prospectus dated November 22, 1999 relating to the
sale of up to 1,000,000,000 depositary receipts by Biotech HOLDRs SM Trust.

     The share amounts specified in the table on page 9 of the accompanying
prospectus shall be replaced with the following:



                                                          Primary
                                                   Share  Trading
                Name of Company            Ticker Amounts Market
                ---------------            ------ ------- -------
                  Amgen Inc.                AMGN    46    NASDAQ
                Genentech, Inc.             DNA     22     NYSE
                 Biogen, Inc.               BGEN    13    NASDAQ
              Immunex Corporation           IMNX    14    NASDAQ
          PE Corp-PE Biosystems Group       PEB      9     NYSE
                MedImmune, Inc.             MEDI     5    NASDAQ
              Chiron Corporation            CHIR    16    NASDAQ
              Genzyme Corporation           GENZ     7    NASDAQ
             Gilead Sciences, Inc.          GILD     4    NASDAQ
               Sepracor Inc. (1)            SEPR     3    NASDAQ
      IDEC Pharmaceuticals Corporation(2)   IDPH     4    NASDAQ
          QLT Photo Therapeutics Inc.       QLTI     5    NASDAQ
       Millennium Pharmaceuticals, Inc.     MLNM     3    NASDAQ
              BioChem Pharma Inc.           BCHE     9    NASDAQ
               Affymetrix, Inc.             AFFX     2    NASDAQ
        Human Genome Sciences, Inc.(3)      HGSI     2    NASDAQ
               ICOS Corporation             ICOS     4    NASDAQ
                  Enzon, Inc.               ENZN     3    NASDAQ
                Celera Genomics             CRA      2     NYSE
                Alkermes, Inc.              ALKS     2    NASDAQ

- -------
(1)  On January 20, 2000, Sepracor Inc. declared a two-for-one stock split on
     its common stock, to be effected by means of a stock dividend to
     shareholders of record on February 1, 2000. The shares of common stock will
     begin trading on a split-adjusted basis on February 28, 2000. At such date,
     the share amount of Sepracor Inc. represented by a round-lot of 100 Biotech
     HOLDRs will be 6.
(2)  IDEC Pharmaceuticals Corporation effected a two-for-one stock split on its
     common stock by means of a stock dividend. The shares of common stock began
     trading on a split-adjusted basis on December 21, 1999. The share amount of
     IDEC Pharmaceuticals Corporation represented by a round-lot of 100 Biotech
     HOLDRs is 4.
(3)  On January 5, 2000, Human Genome Sciences, Inc. declared a two-for-one
     stock split on its common stock, to be effected by means of a stock
     dividend to shareholders of record on January 14, 2000. The shares of
     common stock will begin trading on a split-adjusted basis on January 31,
     2000. At such date, the share amount of Human Genome Sciences, Inc.
     represented by a round-lot of 100 Biotech HOLDRs will be 4.

     The stock prices in the tables set forth in Annex A of the accompanying
prospectus have not been and will not be, adjusted to account for any stock
splits.

           The date of this prospectus supplement is January 21, 2000.







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