BIOTECH HOLDRS TRUST
8-K, 2000-03-03
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                       SECURITIES AND EXCHANGE COMMISSION

                             Washington, D.C. 20549

                                 ---------------

                                    FORM 8-K

                Current Report Pursuant to Section 13 or 15(d) of
                       The Securities Exchange Act of 1934

        Date of Report (Date of earliest event reported):February 1, 2000

                             Biotech HOLDRsSM Trust
                                Initial Depositor
             (Exact name of registrant as specified in its charter)

                             Biotech HOLDRsSM Trust
                      [Issuer with respect to the receipts]

                                    New York
                 (State or other jurisdiction of incorporation)

                             Commission File Number

                                 Not applicable
                      (I.R.S. Employer Identification No.)

                      c/o The Bank of New York, as Trustee
                            101 Barclay Street, 22-W
                               New York, New York
              (Address of principal executive offices and zip code)

                               Page 1 of 5 pages.
                      The Exhibit Index appears at Page 4.


<PAGE>


Item 5.  Other Events

         Immunex Corporation has declared a three-for-one stock split on its
common stock, to be effected by means of a stock dividend to shareholders of
record on March 6, 2000. The shares of common stock will begin trading on a
split-adjusted basis on March 21, 2000. At such date, the share amount of
Immunex Corporation represented by a round-lot of 100 Biotech HOLDRs will be 42.

         MedImmune, Inc. has declared a three-for-one stock split on its common
stock, to be effected by means of a stock dividend to shareholders of record on
May 18, 2000. The shares of common stock will begin trading on a split-adjusted
basis on June 5, 2000. At such date, the share amount of MedImmune, Inc.
represented by a round-lot of 100 Biotech HOLDRs will be 15.

         Sepracor Inc. declared a two-for-one stock split on its common stock,
to be effected by means of a stock dividend to shareholders of record on
February 1, 2000. The shares of common stock began trading on a split-adjusted
basis on February 28, 2000. The share amount of Sepracor Inc. represented by a
round-lot of 100 Biotech HOLDRs is 6.

Item 7.  Financial Statements, Pro Forma Financial Information and Exhibits

         (c) Exhibits

               (99) Biotech HOLDRsSM Trust Prospectus Supplement No.  2 dated
                    March 2, 2000 to Prospectus dated November 22, 1999.











                                        2


<PAGE>


                                    SIGNATURE

         Pursuant to the requirements of the Securities Exchange Act of 1934,
the registrant has duly caused this report to be signed on its behalf by the
undersigned hereunto duly authorized.



                              MERRILL LYNCH, PIERCE, FENNER & SMITH INCORPORATED


Date: March 3, 2000           By:  /s/ Stephen G. Bodurtha
                                   ---------------------------
                                   Name:  Stephen G. Bodurtha
                                   Title: Attorney-in-Fact
















                                        3

<PAGE>


                                  EXHIBIT INDEX

Number and Description of Exhibit                            Sequential
- ---------------------------------                            Page Number
                                                             -----------

(99) Biotech HOLDRsSM Trust Prospectus                          Pg. 5
Supplement No. 2 dated March 2, 2000 to
Prospectus dated November 22, 1999.





















                                        4



PROSPECTUS SUPPLEMENT No. 2
- ----------------------------
(To Prospectus dated November 22, 1999)


                                [GRAPHIC OMITTED]


                        1,000,000,000 Depositary Receipts
                             Biotech HOLDRsSM Trust

This prospectus supplement amends and supplements certain information contained
in the accompanying prospectus dated November 22, 1999 relating to the sale of
up to 1,000,000,000 depositary receipts by Biotech HOLDRsSM Trust.

The share amounts specified in the table on page 9 of the accompanying
prospectus shall be replaced with the following:

<TABLE>
<CAPTION>

                                                                                                     Primary
                                                                                                     Trading
                   Name of Company                            Ticker           Share Amounts          Market
                   ---------------                            ------           -------------         -------
<S>                                                           <C>                   <C>              <C>
                      Amgen Inc.                               AMGN                  46               NASDAQ
                   Genentech, Inc.                              DNA                  22                NYSE
                     Biogen, Inc.                              BGEN                  13               NASDAQ
                Immunex Corporation(1)                         IMNX                  14               NASDAQ
             PE Corp-PE Biosystems Group                        PEB                 18*                NYSE
                  MedImmune, Inc.(2)                           MEDI                  5                NASDAQ
                  Chiron Corporation                           CHIR                  16               NASDAQ
                 Genzyme Corporation                           GENZ                  7                NASDAQ
                Gilead Sciences, Inc.                          GILD                  4                NASDAQ
                    Sepracor Inc.                              SEPR                  6*               NASDAQ
           IDEC Pharmaceuticals Corporation                    IDPH                  4*               NASDAQ
             QLT Photo Therapeutics Inc.                       QLTI                  5                NASDAQ
         Millennium Pharmaceuticals, Inc. (3)                  MLNM                  3                NASDAQ
                 BioChem Pharma Inc.                           BCHE                  9                NASDAQ
                   Affymetrix, Inc.                            AFFX                  2                NASDAQ
             Human Genome Sciences, Inc.                       HGSI                  4*               NASDAQ
                   ICOS Corporation                            ICOS                  4                NASDAQ
                     Enzon, Inc.                               ENZN                  3                NASDAQ
                   Celera Genomics                              CRA                  4*                NYSE
                    Alkermes, Inc.                             ALKS                  2                NASDAQ

</TABLE>

- ----------
*  Reflects adjustment for previous stock split.

(1)  Immunex Corporation has declared a three-for-one stock split on its common
     stock, to be effected by means of a stock dividend to shareholders of
     record as of March 6, 2000. The shares of common stock will begin trading
     on a split-adjusted basis on March 21, 2000. At such date, the share amount
     of Immunex Corporation represented by a round-lot of 100 Biotech HOLDRs
     will be 42.

(2)  MedImmune, Inc. has declared a three-for-one stock split on its common
     stock, to be effected by means of a stock dividend to shareholders of
     record as of May 18, 2000. The shares of common stock will begin trading on
     a split-adjusted basis on June 5, 2000. At such date, the share amount of
     MedImmune, Inc. represented by a round-lot of 100 Biotech HOLDRs will be
     15.

(3)  Millennium Pharmaceuticals, Inc. declared a two-for-one stock split on its
     common stock, to be effected by means of a stock dividend to shareholders
     of record on March 28, 2000. The shares of common stock will begin trading
     on a split-adjusted basis on April 19, 2000. At such date, the share amount
     of Millenium Pharmaceuticals, Inc. represented by a round-lot of 100
     Biotech HOLDRs will be 6.

The stock prices in the tables set forth in Annex A of the accompanying
prospectus have not been and will not be, adjusted to account for any stock
splits.

            The date of this prospectus supplement is March 2, 2000.



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