MERRILL LYNCH SERIES FUNDS INC
497, 2001-01-19
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                         MERRILL LYNCH SERIES FUND, INC.

                    Supplement dated January 19, 2001 to the
                         Prospectus dated April 4, 2000

         The  following   information   supersedes  and  replaces  any  contrary
information  contained in the Prospectus  under the captions  "Details About the
Portfolio--Investment    Risks"   and   "Other    Important    Information--Your
Account--Investment Strategies--Futures and
Options."

         Effective  today,  each of the  Portfolios  (except  the Money  Reserve
Portfolio)  may engage in  options,  futures  and  options on futures to enhance
total return as well as for hedging  purposes.  For more  information  regarding
futures and options, see "Other Important Information--Your  Account--Investment
Strategies--Futures and Options."



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