GENERAL AMERICAN INVESTORS CO INC
13F-HR, 2000-02-10
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                                 UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, DC  20549

                                    Form 13F

                              FORM 13F COVER PAGE

Report for the Calendar Year or Quarter Ended:   December 31, 1999

Institutional Investment Manager Filing this Report:
Name:    General American Investors Company, Inc.
Address: 450 Lexington Avenue, Suite 3300
         New York, NY  10017

13F File Number: 28-461

The institutional investment manager filing this report and the person by whom
it is signed hereby represent that the person signing the report is authorized
to submit it, that all information contained herein is true, correct and
complete, and that it is understood that all required items, statements,
schedules, lists, and tables, are considered integral parts of this form.

Person Signing this Report:
Name:  Eugene L. DeStaebler, Jr.
Title: Vice-President, Administration
Phone: 212-916-8400
Signature, Place and Date of Signing:
     Eugene L. DeStaebler, Jr.     New York, NY      February 10, 2000

Report Type  (Check only one.):

[x]       13F HOLDINGS REPORT
[ ]       13F NOTICE
[ ]       13F COMBINATION REPORT

List of Other Managers Reporting for this Manager:
    NONE

I am signing this report as required by the Securities Exchange Act of 1934.
<PAGE>
                     FORM 13F SUMMARY PAGE

Report Summary:
Number of Other Included Managers:      0
Form 13F Information Table Entry Total: 66
Form 13F Information Table Value Total: $1,006,502,783

<PAGE>
<TABLE>

      NAME OF ISSUER         TITLE    CUSIP          FAIR      SHARES OR          INVEST. DISC.    OTHER      VOTING AUTHORITY
                              OF      NUMBER        MARKET     PRINCIPAL  SH/               SHARED  MGRS.
                             CLASS                   VALUE      AMOUNT    PRN    SOLE SHARED OTHER        SOLE     SHARED   NONE
                                                                                 (A)   (B)   (C)          (A)       (B)      (C)
 ----------------------------------------------------------------------------------------------------------------------------------
 <S>                                             <C>           <C>                                      <C>
 Adams Express Company      COMMON 006212104       1,619,314      48,247  SH      X                        48,247
 American International Gro COMMON 026874107      16,218,750     150,000  SH      X                       150,000
 Alkermes, Inc.             COMMON 01642T108       2,456,250      50,000  SH      X                        50,000
 Annuity and Life Re (Holdi COMMON G03910109      13,650,313     522,500  SH      X                       522,500
 AmerUs Life Holdings, Inc. COMMON 030732101      10,350,000     450,000  SH      X                       450,000
 AMR Corporation            COMMON 001765106      23,450,000     350,000  SH      X                       350,000
 Buffets, Inc.              COMMON 119882108      16,375,000   1,637,500  SH      X                     1,637,500
 BioReliance Corporation    COMMON 090951104       1,812,844     317,000  SH      X                       317,000
 Berkshire Hathaway Inc.    COMMON 084670108      17,671,500         315  SH      X                           315
 Brooks Automation, Inc.    COMMON 11434A100       1,709,531      52,500  SH      X                        52,500
 CCB Financial Corp.        COMMON 124875105       6,752,188     155,000  SH      X                       155,000
 Central Securities Corpora COMMON 155123102       1,791,960      65,760  SH      X                        65,760
 Consolidated Stores Corpor COMMON 210149100       6,093,750     375,000  SH      X                       375,000
 Cox Communications, Inc. - COMMON 224044107      33,175,270     644,180  SH      X                       644,180
 Cisco Systems, Inc.        COMMON 17275R102      44,992,500     420,000  SH      X                       420,000
 C-Cube Microsystems Inc.   COMMON 125015107       9,337,500     150,000  SH      X                       150,000
 Covance Inc.               COMMON 222816100       4,865,625     450,000  SH      X                       450,000
 DuPont Photomasks, Inc.    COMMON 26613X101       5,790,000     120,000  SH      X                       120,000
 EMCORE Corporation         COMMON 290846104      10,030,000     295,000  SH      X                       295,000
 Ethan Allen Interiors, Inc COMMON 297602104       1,603,125      50,000  SH      X                        50,000
 Ford Motor Company         COMMON 345370100      34,653,125     650,000  SH      X                       650,000
 First Midwest Bancorp, Inc COMMON 320867104      10,931,250     412,500  SH      X                       412,500
 Golden West Financial      COMMON 381317106      16,080,000     480,000  SH      X                       480,000
 GelTex Pharmaceuticals, In COMMON 368538104       6,854,688     535,000  SH      X                       535,000
 Huntington Bancshares      COMMON 446150104       4,595,938     192,500  SH      X                       192,500
 The Home Depot, Inc.       COMMON 437076102     147,468,750   2,145,000  SH      X                     2,145,000
 Huntingdon Life Sciences   COMMON 445891203         491,719     524,500  SH      X                       524,500
 IDEC Pharmaceuticals Corpo COMMON 449370105      58,458,750     595,000  SH      X                       595,000
 Interim Services Inc.      COMMON 45868P100       9,900,000     400,000  SH      X                       400,000
 Johnson & Johnson          COMMON 478160104      11,917,350     127,800  SH      X                       127,800
 Lam Research Corporation   COMMON 512807108      59,685,938     535,000  SH      X                       535,000
 Magainin Pharmaceuticals I COMMON 559036108         489,375     270,000  SH      X                       270,000
 Manugistics Group, Inc.    COMMON 565011103      10,663,125     330,000  SH      X                       330,000
 MetaCreations Corporation  COMMON 591016100       2,363,281     275,000  SH      X                       275,000
 Medtronic, Inc.            COMMON 585055106      10,931,250     300,000  SH      X                       300,000
 MedImmune, Inc.            COMMON 584699102      24,257,394     146,239  SH      X                       146,239
 Philip Morris Companies In COMMON 718154107       5,750,000     250,000  SH      X                       250,000
 Molex Incorporated Class A COMMON 608554200      22,511,875     497,500  SH      X                       497,500
 M&T Bank Corporation       COMMON 55261F104      18,641,250      45,000  SH      X                        45,000
 Annaly Mortgage Management COMMON 035710409       4,812,500     550,000  SH      X                       550,000
 NTL Incorporated           COMMON 629407107      31,499,375     252,500  SH      X                       252,500
 Ortel Corporation          COMMON 68749W102       5,100,000      42,500  SH      X                        42,500
 PairGain Technologies, Inc COMMON 695934109       3,192,188     225,000  SH      X                       225,000
 pcOrder.com, Inc.          COMMON 70453H107       2,295,000      45,000  SH      X                        45,000
 PepsiCo, Inc.              COMMON 713448108       7,050,000     200,000  SH      X                       200,000
 Pfizer Inc.                COMMON 717081103      28,707,188     885,000  SH      X                       885,000
 PRI Automation, Inc.       COMMON 69357H106      16,445,625     245,000  SH      X                       245,000
 Quintiles Transnational Co COMMON 748767100       4,671,875     250,000  SH      X                       250,000
 Everest Reinsurance Holdin COMMON 299808105      18,965,625     850,000  SH      X                       850,000
 Repsol, S.A. - ADR         COMMON 76026T205      16,275,000     700,000  SH      X                       700,000
 Reinsurance Group of Ameri COMMON 759351109       4,023,750     145,000  SH      X                       145,000
 ReliaStar Financial Corp.  COMMON 75952U103      11,364,375     290,000  SH      X                       290,000
 Royce Value Trust          COMMON 780910105         763,585      58,454  SH      X                        58,454
 Seagate Technology, Inc.   COMMON 811804103      20,021,875     430,000  SH      X                       430,000
 Saks Incorporated          COMMON 79377W108       9,337,500     600,000  SH      X                       600,000
 Sun Trust Banks, Inc.      COMMON 867914103      16,170,938     235,000  SH      X                       235,000
 The ServiceMaster Company  COMMON 81760N109       9,683,781     786,500  SH      X                       786,500
 The TJX Companies, Inc.    COMMON 872540109      17,371,875     850,000  SH      X                       850,000
 TriQuint Semiconductor, In COMMON 89674K103       3,671,250      33,000  SH      X                        33,000
 Transatlantic Holdings, In COMMON 893521104      15,612,500     200,000  SH      X                       200,000
 Tri-Continental Corporatio COMMON 895436103       1,478,518      53,041  SH      X                        53,041
 Uniroyal Technology Corpor COMMON 909163107       9,894,000     388,000  SH      X                       388,000
 Wind River Systems, Inc.   COMMON 973149107       7,325,000     200,000  SH      X                       200,000
 Waste Management, Inc.     COMMON 94106L109       7,098,438     413,000  SH      X                       413,000
 Wal-Mart Stores, Inc.      COMMON 931142103      39,401,250     570,000  SH      X                       570,000
 XL Capital Ltd.            COMMON G98255105       7,879,294     151,890  SH      X                       151,890
</TABLE>


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