ALZA CORP
DEF 14A, 1995-03-21
PHARMACEUTICAL PREPARATIONS
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<PAGE>
                            SCHEDULE 14A INFORMATION

                  Proxy Statement Pursuant to Section 14(a) of
            the Securities Exchange Act of 1934 (Amendment No.    )

    Filed by the Registrant / /
    Filed by a Party other than the Registrant /X/

    Check the appropriate box:
    / /  Preliminary Proxy Statement
    / /  Confidential, for Use of the Commission Only (as permitted by Rule
         14a-6(e)(2))
    /X/  Definitive Proxy Statement
    / /  Definitive Additional Materials
    / /  Soliciting  Material  Pursuant  to  Section  240.14a-11(c) or  Section
         240.14a-12
                         ALZA CORPORATION
- --------------------------------------------------------------------------------
                (Name of Registrant as Specified In Its Charter)
                        MERRILL CORPORATION
- --------------------------------------------------------------------------------
    (Name of Person(s) Filing Proxy Statement, if other than the Registrant)

Payment of Filing Fee (Check the appropriate box):

/X/  $125 per  Exchange Act  Rules 0-11(c)(1)(ii),  14a-6(i)(1), 14a-6(i)(2)  or
     Item 22(a)(2) of Schedule 14A.
/ /  $500  per  each party  to  the controversy  pursuant  to Exchange  Act Rule
     14a-6(i)(3).
/ /  Fee  computed  on   table  below   per  Exchange   Act  Rules   14a-6(i)(4)
     and 0-11.
     1) Title of each class of securities to which transaction applies:
        ------------------------------------------------------------------------
     2) Aggregate number of securities to which transaction applies:
        ------------------------------------------------------------------------
     3) Per unit price or other underlying value of transaction computed
        pursuant to Exchange Act Rule 0-11 (Set forth the amount on which the
        filing fee is calculated and state how it was determined):
        ------------------------------------------------------------------------
     4) Proposed maximum aggregate value of transaction:
        ------------------------------------------------------------------------
     5) Total fee paid:
        ------------------------------------------------------------------------
/ /  Fee paid previously with preliminary materials.
/ /  Check box if any part of the fee is offset as provided by Exchange Act Rule
     0-11(a)(2)  and identify the  filing for which the  offsetting fee was paid
     previously. Identify the previous filing by registration statement  number,
     or the Form or Schedule and the date of its filing.
     1) Amount Previously Paid:
        ------------------------------------------------------------------------
     2) Form, Schedule or Registration Statement No.:
        ------------------------------------------------------------------------
     3) Filing Party:
        ------------------------------------------------------------------------
     4) Date Filed:
        ------------------------------------------------------------------------

<PAGE>
                                     [LOGO]

                                ALZA CORPORATION
                             ---------------------

                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
                      TO BE HELD MAY 11, 1995 AT 10:00 AM
                            ------------------------

To the Stockholders of ALZA Corporation:

    NOTICE  IS  HEREBY GIVEN  that the  Annual Meeting  of Stockholders  of ALZA
Corporation will  be held  at 950  Page  Mill Road,  Palo Alto,  California,  on
Thursday, May 11, 1995 at 10:00 am, for the following purposes:

        1.   To elect two Class II directors to hold office for a term ending in
    1998 and until their successors are elected;

        2.  To amend and restate ALZA's  1992 Stock Option Plan (i) to  increase
    by  3,000,000 the  number of  shares of  Common Stock  reserved for issuance
    under the plan; (ii) to limit the  number of shares as to which options  may
    be granted to any participant under the plan; (iii) to provide for grants of
    restricted  stock  under the  plan; and  (iv)  to rename  the plan  the ALZA
    Corporation Amended and Restated Stock Plan;

        3.  To amend and restate ALZA's 1984 Employee Stock Purchase Plan (i) to
    increase by  500,000 the  number  of shares  of  Common Stock  reserved  for
    issuance under the plan; (ii) to provide for semi-annual (in lieu of annual)
    purchases and enrollments; and (iii) to rename the plan the ALZA Corporation
    Amended and Restated Employee Stock Purchase Plan;

        4.  To consider and act upon a stockholder proposal, if presented at the
    meeting;

        5.  To ratify the appointment of Ernst & Young LLP as ALZA's independent
    auditors for the fiscal year ended December 31, 1995; and

        6.   To transact such other business as may properly be presented at the
    meeting and at any adjournments or postponements thereof.

    Only holders of record of  ALZA's Common Stock at  the close of business  on
March  14, 1995 are entitled to  notice of, and to vote  at, the meeting and any
adjournments or postponements thereof.

                                          By Order of the Board of Directors,

                                                JULIAN N. STERN
                                                   SECRETARY

Palo Alto, California
March 21, 1995

    WHETHER OR  NOT YOU  PLAN TO  ATTEND  THE ANNUAL  MEETING, PLEASE  SIGN  THE
ACCOMPANYING  PROXY CARD AND RETURN  IT AS SOON AS  POSSIBLE IN THE ACCOMPANYING
POSTPAID ENVELOPE. YOUR DOING SO MAY SAVE ALZA THE EXPENSE OF A SECOND MAILING.
<PAGE>
                                ALZA CORPORATION

                                PROXY STATEMENT
                            ------------------------

To the Stockholders of ALZA Corporation:

    The accompanying proxy is solicited on behalf of the Board of Directors (the
"Board") of ALZA Corporation ("ALZA"), a Delaware corporation, for use at ALZA's
Annual  Meeting of Stockholders (the "Annual Meeting") to be held at 10:00 am on
Thursday, May 11,  1995 at ALZA's  headquarters located at  950 Page Mill  Road,
Palo Alto, California 94304; telephone number (415) 494-5000.

    Only holders of record of ALZA's Common Stock as of the close of business on
March 14, 1995 are entitled to notice of, and to vote at, the Annual Meeting and
any  adjournments or  postponements thereof.  At the  close of  business on that
date, ALZA had outstanding 82,087,188 shares of its Common Stock, par value $.01
per share. Holders of Common  Stock are entitled to one  vote for each share  of
Common Stock held.

    Any  holder of  Common Stock  giving a proxy  in the  form accompanying this
Proxy Statement has the power to revoke the proxy prior to its use. A proxy  can
be  revoked (i)  by an  instrument of revocation  delivered prior  to the Annual
Meeting to the Secretary of ALZA, (ii) by a duly executed proxy bearing a  later
date  or time than the date or time of  the proxy being revoked, or (iii) at the
Annual Meeting if the stockholder is present and elects to vote in person.  Mere
attendance at the Annual Meeting will not serve to revoke a proxy.

    Broker  non-votes, and shares  held by stockholders present  in person or by
proxy at the meeting but  abstaining on a vote,  will be counted in  determining
whether  a  quorum is  present at  the Annual  Meeting. However,  abstentions by
stockholders present in person or by proxy  at the meeting are counted as  votes
against  a proposal for  purposes of determining  whether or not  a proposal has
been approved,  whereas  broker  non-votes  are  not  counted  for  purposes  of
determining whether a proposal has been approved.

    This  Proxy Statement  and the accompanying  proxy card are  being mailed to
ALZA stockholders on  or about  March 21,  1995. Directors,  officers and  other
employees  of  ALZA  may  solicit  proxies  by  personal  interview,  telephone,
telegraph  or  facsimile,  without  special  compensation.  Any  costs  of  such
solicitation will be borne by ALZA.

                             ELECTION OF DIRECTORS

    ALZA's Certificate of Incorporation provides for three classes of directors:
Class  I, Class II and Class III. Only one class of directors is elected at each
annual meeting of stockholders, each director to serve for a three-year term. In
accordance with the Certificate of Incorporation,  Class II directors are to  be
elected at the 1995 annual meeting, Class III directors are to be elected at the
1996  annual meeting and Class I directors are  to be elected at the 1997 annual
meeting.

NOMINEES

    There currently are  three Class  II directors.  On February  16, 1995,  the
Board of Directors voted to amend ALZA's Bylaws, effective as of the date of the
Annual  Meeting, to decrease the number of directors constituting the Board from
ten to nine  directors because  Dr. Jane E.  Shaw, ALZA's  former President  and
Chief  Operating Officer, will not  be standing for re-election.  As a result of
this amendment, two Class  II directors are  to be elected to  the Board at  the
Annual  Meeting, each to  serve until the  annual meeting of  stockholders to be
held in 1998 and until  his successor has been  elected and qualified, or  until
his  earlier death,  resignation or  removal. The  nominees for  election at the
Annual Meeting are Dr. Robert J. Glaser and Dean O. Morton.

    Both of the nominees presently are  directors of ALZA. If either nominee  is
unable  or  unwilling  to  serve as  a  director,  proxies may  be  voted  for a
substitute nominee designated by the present Board.

                                       1
<PAGE>
The Board  has no  reason  to believe  that either  nominee  will be  unable  or
unwilling  to serve  as a  director if elected.  Proxies received  will be voted
"FOR" the election of both nominees  unless marked to the contrary. Pursuant  to
applicable  Delaware corporation  law, assuming  the presence  of a  quorum, two
directors will  be elected  from among  those persons  duly nominated  for  such
positions  by a plurality of the votes actually cast by stockholders entitled to
vote at the meeting who  are present in person or  by proxy. Thus, nominees  who
receive  the first and second highest number of votes in favor of their election
will be elected, regardless of the number of abstentions or non-votes.

    The following  table provides  the names  of the  nominees for  election  as
directors  and each other director  who will be serving  as a director after the
Annual Meeting and indicates the periods  during which such persons have  served
as directors of ALZA.

<TABLE>
<CAPTION>
                                                                                                         DIRECTOR
                                                                                                       CONTINUOUSLY
NAME AND POSITIONS WITH ALZA IN ADDITION TO DIRECTOR                                                       SINCE
- ----------------------------------------------------------------------------------------------------  ---------------
<S>                                                                                                   <C>
NOMINEES (CLASS II DIRECTORS)

  Dr. Robert J. Glaser..............................................................................          1987
  Dean O. Morton....................................................................................          1987

INCUMBENTS (CLASS I AND CLASS III DIRECTORS)

CLASS I DIRECTORS
  William G. Davis..................................................................................          1989
  Martin S. Gerstel.................................................................................          1980
  Julian N. Stern...................................................................................          1982
   Secretary

CLASS III DIRECTORS
  Dr. Ernest Mario..................................................................................          1993
   Co-Chairman and Chief Executive Officer
  Rudolph A. Peterson...............................................................................          1969
  Isaac Stein.......................................................................................          1987
  Dr. Alejandro Zaffaroni...........................................................................          1968
   Co-Chairman and Founder
</TABLE>

BUSINESS EXPERIENCE OF DIRECTORS

    NOMINEES (CLASS II DIRECTORS)

    Dr.  Robert J. Glaser, 76, has been  the Director for Medical Science of the
Lucille P. Markey Charitable Trust since  1984, and a trustee since 1988.  Prior
to  that time  he was President,  Chief Executive  Officer and a  trustee of the
Henry J.  Kaiser  Family  Foundation.  Dr.  Glaser  is  a  director  of  Nellcor
Incorporated  and Hanger Orthopedic Group, Inc. In 1991, Dr. Glaser retired as a
director of Hewlett-Packard Company after serving since 1971.

    Dean O. Morton,  63, retired in  October 1992 as  Executive Vice  President,
Chief Operating Officer and a director of Hewlett-Packard Company, where he held
various  positions since 1960. Mr. Morton  is a director of Raychem Corporation,
Clorox Company, Centigram Communications  Corporation, Metropolitan Series  Fund
and Metlife Portfolios and Tencor Instruments. He is also a trustee of the State
Street Research & MetLife-State Street Funds.

    INCUMBENTS (CLASS I AND CLASS III DIRECTORS)
    CLASS I DIRECTORS

    William  G. Davis, 63,  is an independent business  consultant. Prior to his
retirement from  Eli Lilly  & Company  in 1984,  Mr. Davis  held various  senior
executive  positions during his 27-year tenure with that company. Mr. Davis is a
director of  ABIOMED, Inc.,  Collagen  Corporation, Endosonics  Corporation  and
Target Therapeutics, Inc.

                                       2
<PAGE>
    Martin  S. Gerstel,  53, retired  in August  1993 as  ALZA's Co-Chairman and
Chief Executive  Officer, having  served in  such capacity  since 1987,  and  as
ALZA's  Chief Financial Officer, having served  in such capacity since 1968. Mr.
Gerstel served as ALZA's President from 1982 until 1987 and its Chief  Operating
Officer  from 1980  to 1987.  Mr. Gerstel is  currently a  part-time employee of
ALZA, undertaking special projects as requested by the Chief Executive  Officer.
He is also a director of TEVA Pharmaceutical Industries of Israel.

    Julian  N. Stern, 70, has been Secretary of  ALZA since 1968. He is the sole
employee of a  professional corporation  that is  a member  of the  law firm  of
Heller, Ehrman, White & McAuliffe.

    CLASS III DIRECTORS

    Dr.  Ernest Mario,  56, is  the Co-Chairman  and Chief  Executive Officer of
ALZA. Prior  to joining  ALZA, Dr.  Mario  served as  Chief Executive  of  Glaxo
Holdings  plc, a  pharmaceutical corporation,  from 1989  to March  1993, and as
Deputy Chairman from January 1992 to March  1993. Prior to that time, Dr.  Mario
served  as Chairman and Chief Executive Officer  of Glaxo, Inc., a subsidiary of
Glaxo Holdings, from 1988 to 1989  and as President and Chief Operating  Officer
of  Glaxo, Inc., from 1986  to 1988. Prior to joining  Glaxo, Dr. Mario had held
various executive positions with E. R. Squibb & Sons since 1977.

    Rudolph A.  Peterson,  90, is  the  President and  Chief  Executive  Officer
(retired)  and honorary director of Bank America Corporation and Bank of America
N.T. & S.A. and  the Administrator (retired) of  the United Nations  Development
Programme.

    Isaac  Stein, 48, has been President of Waverley Associates, Inc., a private
investment firm, since 1983. Mr. Stein served as Chairman of the Board of Esprit
de Corp from  June 1990 to  December 1992. Mr.  Stein is also  a trustee of  the
Benham Group of Mutual Funds and a director of Raychem Corporation.

    Dr.  Alejandro Zaffaroni, 72, the founder of  ALZA, has been Chairman of the
Board of ALZA since 1982 (Co-Chairman since 1987) and was ALZA's Chief Executive
Officer from 1968 until  1987. He was  President of ALZA  from 1968 until  1982.
From  1988 to  March 1,  1995, Dr.  Zaffaroni was  Chairman and  Chief Executive
Officer of Affymax N.V.,  a drug discovery company.  He currently spends 50%  of
his time on the affairs of ALZA and, prior to March 1, 1995, he spent 50% of his
time on those of Affymax N.V.

MEETINGS AND COMMITTEES OF THE BOARD

    There  were eight meetings of  the full Board during  fiscal 1994. The Board
has two standing  committees, the  Compensation and Benefits  Committee and  the
Finance  and  Audit  Committee.  The current  members  of  the  Compensation and
Benefits Committee are Dr. Glaser, Mr. Morton, and Mr. Stein, none of whom is an
employee of ALZA. The Compensation and Benefits Committee, which met four  times
during  1994, approves all of ALZA's  compensation plans, including the awarding
of options under ALZA's stock option plan, and the compensation arrangements for
ALZA's senior management. The Finance and Audit Committee, which met four  times
during  fiscal 1994, consults with  ALZA's independent auditors concerning their
auditing plan, the  results of  their audit, the  appropriateness of  accounting
principles  used by ALZA and the adequacy of ALZA's general accounting controls.
The current  members of  the Finance  and Audit  Committee are  Messrs.  Morton,
Peterson,  Stern, Davis and Stein,  none of whom is  an employee of ALZA. During
1994, each director attended at least 75% of the meetings of the full Board  and
the committees of the Board on which he or she served.

    ALZA  has  no  standing  nominating committee.  ALZA's  Bylaws  provide that
stockholders may nominate candidates  for election as  directors by delivery  of
written  notice  to ALZA's  Secretary  at least  sixty  days in  advance  of the
stockholders' meeting or ten days after notice of the meeting is first given  to
stockholders,  whichever is later. Any  such notice must set  forth the name and
address of  the nominating  stockholder and  the nominee,  and such  information
concerning both such persons as

                                       3
<PAGE>
would  be required by the  rules and regulations of  the Securities and Exchange
Commission to  be included  in  a proxy  statement  soliciting proxies  for  the
election  of the nominee. The notice must  be accompanied by the written consent
of the nominee to serve as a director, if elected.

    Each director who is not an employee of ALZA receives an annual retainer fee
of $20,000. Prior to August 11, 1994,  each director who was not an employee  of
ALZA  received fees of $500 for attendance at  each meeting day of the Board and
any committee on which the director served; the chairmen of the Compensation and
Benefits Committee and the Finance and  Audit Committee received fees of  $1,000
for  each meeting  day of their  respective committee  in lieu of  the $500 fee.
Effective August 11, 1994, each director who is not an employee of ALZA receives
fees of $1,000 for attendance at each meeting day of the Board and $750 for each
regular meeting of any committee on which the director serves and $500 for  each
special  meeting  of any  committee  on which  the  director serves  (except for
chairmen of the  committees who  receive $1,250 for  each meeting  day of  their
respective  committees). In  addition, each director  who is not  an employee of
ALZA receives a fee of $350 for attendance at each teleconference meeting of the
Board lasting more than one hour. ALZA's Secretary receives a fee for  attending
meetings of the Compensation and Benefits Committee equal to the fee paid to the
directors  who serve  on that  committee. ALZA's  non-employee directors receive
options to purchase Common Stock pursuant  to the automatic grant provisions  of
ALZA's stock option plan.

                             EXECUTIVE COMPENSATION
                           SUMMARY COMPENSATION TABLE

    The  following table sets forth certain information relating to compensation
paid or accrued for services in all capacities during the fiscal years indicated
with respect to Dr. Ernest Mario, ALZA's Chief Executive Officer, each of ALZA's
other four  most  highly compensated  executive  officers who  were  serving  as
executive  officers  as  of December  31,  1994,  and Dr.  Jane  E.  Shaw, whose
employment as  ALZA's  President  and  Chief  Operating  Officer  terminated  on
September 30, 1994 (the "Named Executive Officers").

<TABLE>
<CAPTION>
                                                                                                LONG-TERM
                                                                                              COMPENSATION
                                                        ANNUAL COMPENSATION                      AWARDS
                                       -----------------------------------------------------  -------------
                                                                                 OTHER         SECURITIES
                                                                                 ANNUAL        UNDERLYING       ALL OTHER
NAME AND PRINCIPAL POSITIONS             YEAR     SALARY (1)   BONUS (1)(2) COMPENSATION (3)   OPTIONS (4)   COMPENSATION (5)
- -------------------------------------  ---------  -----------  -----------  ----------------  -------------  ----------------
<S>                                    <C>        <C>          <C>          <C>               <C>            <C>
Dr. Ernest Mario (6)                        1994  $   541,667   $  --          $   68,316           75,000     $     31,864
 Co-Chairman and Chief Executive            1993      250,000      25,000          --              750,000            6,063
 Officer
Dr. Alejandro Zaffaroni (6)                 1994      245,835      --              --              --               177,284
 Co-Chairman and Founder                    1993      222,917      15,000          --              --               148,695
                                            1992      212,500      20,000          --              --               120,892
Dr. Felix Theeuwes                          1994      287,498      30,000          --               75,000           80,337
 President, ALZA Technology Institute       1993      246,834      20,000          --               25,000           85,335
 and Chief Scientist                        1992      231,000      30,000          --              --                66,865
Dr. Samuel R. Saks                          1994      260,334      40,000          --               60,000            5,905
 Senior Vice President,
 Medical Affairs
Adrian M. Gerber                            1994      246,670      22,000          21,853           20,000           25,820
 Executive Vice President, Commercial       1993      237,450      20,000          43,706           20,000           34,632
 Development                                1992      224,700      30,000          56,700          --                30,231
Dr. Jane E. Shaw (6)                        1994      342,315      --              --               30,000          163,134
 Former President and Chief Operating       1993      317,921      30,000          --              100,000          111,729
 Officer                                    1992      282,528      40,000          --              --                95,358
</TABLE>

                                       4
<PAGE>
<TABLE>
<S>                                    <C>        <C>          <C>          <C>               <C>            <C>
<FN>
- ------------------------
(1)  Amounts  shown  include  compensation  earned  and  received  by  the Named
     Executive Officers as  well as  amounts deferred  at the  election of  such
     persons  under ALZA's Executive Deferral  Plans and Tax Deferral Investment
     Plan.
(2)  Bonuses consist of  amounts paid under  ALZA's PACE bonus  program (or  the
     predecessor Executive Incentive Plan, which has been discontinued).
(3)  Amount  shown for  Dr. Mario consists  of relocation  expenses incurred and
     paid  in  1994.  Amounts  shown  for  Mr.  Gerber  consist  of  a  mortgage
     differential benefit paid for the years shown (see "Certain Transactions").
(4)  The  options were granted for a term of ten years. All unvested options are
     subject to  earlier  termination in  the  event  of the  termination  of  a
     participant's  relationship with ALZA. Of the options granted to Dr. Mario,
     the option for 75,000 shares is fully exercisable on November 29, 1997  and
     the   option  for  750,000  shares  is  exercisable  in  six  equal  annual
     installments commencing on August 10, 1994.  Of the options granted to  Dr.
     Theeuwes, the option for 75,000 shares is fully exercisable on June 6, 1997
     and  the option for 25,000 shares is  fully exercisable on August 10, 1996.
     The option for 60,000  shares granted to Dr.  Saks is fully exercisable  on
     June  6, 1997. Of the options granted  to Mr. Gerber, one option for 20,000
     shares is exercisable in two equal annual installments commencing on August
     10, 1996 and  the other option  for 20,000 shares  is fully exercisable  on
     August  10, 1996.  The options  granted to Dr.  Shaw for  30,000 shares and
     100,000 shares,  respectively,  are  fully exercisable.  All  options  were
     granted  at  fair market  value on  the date  of grant.  In the  event that
     certain change in  control events  were to  occur, all  such options  would
     become  immediately  exercisable. The  option exercise  price may  be paid,
     subject to certain conditions, by delivery of already owned shares or  with
     the  proceeds  from the  sale  of the  option  shares. The  tax withholding
     obligations related  to  the  exercise  may be  paid,  subject  to  certain
     conditions,  by delivery of already-owned shares or by offset of the shares
     issuable upon  exercise of  the option.  Under the  terms of  ALZA's  stock
     option  plan, the  Compensation and Benefits  Committee retains discretion,
     subject to plan  limits, to  reprice options  and to  otherwise modify  the
     terms  (including  the exercise  price  and vesting  dates)  of outstanding
     options.
(5)  Amounts shown for the fiscal year  ended December 31, 1994 consist of:  (i)
     amounts  contributed  by ALZA  to the  participants' accounts  under ALZA's
     Retirement Plan as follows: $16,292 for  Dr. Theeuwes, $5,905 for Dr.  Saks
     and  $16,292  for Mr.  Gerber, and  (ii)  amounts representing  interest in
     excess of 120% of the applicable federal long-term rate on amounts deferred
     at the election of the participants under ALZA's Executive Deferral  Plans.
     Such  reportable interest for 1994 totalled $31,864 for Dr. Mario, $177,284
     for Dr. Zaffaroni,  $64,045 for  Dr. Theeuwes,  $9,528 for  Mr. Gerber  and
     $103,893  for Dr.  Shaw. Amounts  shown for  Dr. Shaw  also include $15,492
     received as the recipient  of ALZA's Founder's Award  for 1994 and  $43,750
     pursuant  to an agreement between ALZA and  Dr. Shaw in connection with the
     termination of her employment with ALZA (see "Certain Transactions").
(6)  Dr. Mario joined ALZA in August 1993. Dr. Zaffaroni devoted 50% of his time
     to the affairs of ALZA during 1992, 1993 and 1994. Dr. Shaw's employment as
     ALZA's President and  Chief Operating Officer  terminated on September  30,
     1994.
</TABLE>

                                       5
<PAGE>
                               1994 OPTION GRANTS

    The  following table sets  forth information relating  to options granted in
1994 to the Named Executive Officers. In addition, in accordance with the  rules
of  the Securities and  Exchange Commission, the  table shows hypothetical gains
that would exist for such options based (i) on assumed rates of annual  compound
stock  price appreciation of 0%,  5% and 10% per year  from the date the options
were granted over  the full option  term, and (ii)  on the Black-Scholes  option
pricing model.
<TABLE>
<CAPTION>
                                                                     INDIVIDUAL GRANTS
                                               -------------------------------------------------------------
                                                  NUMBER OF
                                                 SECURITIES     PERCENT OF TOTAL
                                                 UNDERLYING      OPTIONS GRANTED     EXERCISE
                                                   OPTIONS       TO EMPLOYEES IN     PRICE PER    EXPIRATION
NAME                                             GRANTED (3)       FISCAL YEAR       SHARE (4)       DATE
- ---------------------------------------------  ---------------  -----------------  -------------  ----------
<S>                                            <C>              <C>                <C>            <C>
Dr. Ernest Mario.............................        75,000              7.5     % $     19.25     11/29/04
Dr. Alejandro Zaffaroni......................       --               --                --            --
Dr. Felix Theeuwes...........................        75,000              7.5             25.50       6/6/04
Dr. Samuel R. Saks...........................        60,000              6.0             25.50       6/6/04
Adrian M. Gerber.............................        20,000              2.0             21.75      8/10/04
Dr. Jane E. Shaw.............................        30,000              3.0             21.75      7/30/96

<CAPTION>

                                                      POTENTIAL REALIZABLE VALUE AT          GRANT DATE
                                                      ASSUMED ANNUAL RATES OF STOCK           ESTIMATED
                                                         PRICE APPRECIATION FOR                PRESENT
                                                             OPTION TERM (1)                  VALUE (2)
                                               -------------------------------------------  -------------
NAME                                            0% PER YEAR    5% PER YEAR   10% PER YEAR   BLACK-SCHOLES
- ---------------------------------------------  -------------  -------------  -------------  -------------
<S>                                            <C>            <C>            <C>            <C>
Dr. Ernest Mario.............................  $         0    $     908,250  $   2,301,000  $    726,000
Dr. Alejandro Zaffaroni......................      --              --             --             --
Dr. Felix Theeuwes...........................            0        1,203,000      3,048,000       937,500
Dr. Samuel R. Saks...........................            0          962,400      2,438,400       750,000
Adrian M. Gerber.............................            0          273,600        693,200       213,800
Dr. Jane E. Shaw.............................            0          410,400      1,039,800       320,700
<FN>
- ------------------------------
(1)  The  amounts  represent  certain  assumed rates  of  appreciation  over the
     exercise price per  share (before taxes).  Actual gains, if  any, on  stock
     option  exercises are  dependent on the  future performance  of ALZA Common
     Stock. There can be no assurance that  any of the values reflected in  this
     table will be achieved.

(2)  The  amounts shown  are based  on a  modified Black-Scholes  option pricing
     model. Based on the dates of  their respective grants, the estimated  value
     for Dr. Mario's options assumes a risk-free rate of return of 8.07% and 40%
     volatility;  the estimated values for the options of Drs. Theeuwes and Saks
     assume a risk-free  rate of  return of 7.14%  and 41%  volatility; and  the
     estimated  values  for the  options of  Mr.  Gerber and  Dr. Shaw  assume a
     risk-free rate of return of 7.52% and 39% volatility. The risk-free rate of
     return was derived from U.S.  Strip Treasury zero-coupon bonds maturing  on
     or  about the  time of  option expiration. The  volatility is  based on the
     volatility of ALZA Common Stock for the 36 months preceding the date of the
     respective grant. The estimated  values for all  options assume a  ten-year
     option term and a zero dividend yield. A discount of 25% was applied to the
     option  value yielded  by the  model to  reflect the  nontransferability of
     employee options. The actual  gain realized on options  will depend on  the
     future  price  of the  Common Stock  and cannot  be accurately  forecast by
     application of an option price model.

(3)  For a description of the material terms  of the options, see footnote 4  of
     the Summary Compensation Table.

(4)  Options were granted at an exercise price equal to the fair market value of
     ALZA  Common Stock, as determined  by reference to the  average of the high
     and low price reported on the New York Stock Exchange on the date of grant.
</TABLE>

                                       6
<PAGE>
       1994 AGGREGATED OPTION EXERCISES AND FISCAL YEAR-END OPTION VALUES

    The following table sets forth with respect to the Named Executive  Officers
certain information relating to options exercised during fiscal 1994.

<TABLE>
<CAPTION>
                                                              NUMBER OF SECURITIES        VALUE OF UNEXERCISED
                                                             UNDERLYING UNEXERCISED       IN-THE-MONEY OPTIONS
                                   SHARES        VALUE     OPTIONS AT FISCAL YEAR-END    AT FISCAL YEAR-END (2)
                                 ACQUIRED ON   REALIZED    --------------------------  --------------------------
             NAME                 EXERCISE        (1)      EXERCISABLE  UNEXERCISABLE  EXERCISABLE  UNEXERCISABLE
- -------------------------------  -----------  -----------  -----------  -------------  -----------  -------------
<S>                              <C>          <C>          <C>          <C>            <C>          <C>
Dr. Ernest Mario...............      10,000    $ (12,500)     115,000        700,000   $         0   $         0
Dr. Alejandro Zaffaroni........      --           --           --            --                 --            --
Dr. Felix Theeuwes.............       4,000       26,500       38,000        128,000             0             0
Dr. Samuel R. Saks.............      --           --           10,000         95,000             0             0
Adrian M. Gerber...............      --           --           60,000         60,000        60,000        20,000
Dr. Jane E. Shaw...............      36,000      586,000      270,000        --            325,000            --
<FN>
- ------------------------
(1)  Market  value of  ALZA Common  Stock based  on the  closing sales  price as
     reported on the  composite tape  at the  exercise date  minus the  exercise
     price.

(2)  Market  value of ALZA Common Stock at  fiscal year-end based on the closing
     sales price as reported on the composite tape on December 30, 1994 ($18.00)
     minus the exercise price of "in-the-money"  options. At March 1, 1995,  the
     closing sales price of ALZA Common Stock was $22.50.
</TABLE>

                   COMPENSATION AND BENEFITS COMMITTEE REPORT
                           ON EXECUTIVE COMPENSATION

    The  Compensation and Benefits  Committee (the "Committee")  of the Board of
Directors is generally responsible for decisions concerning the compensation  to
be  paid  to ALZA's  executive  officers. The  Committee  consists of  Robert J.
Glaser, M.D. (Chairman),  Dean O.  Morton and  Isaac Stein,  each of  whom is  a
non-employee  director  of  ALZA.  In  determining  compensation  policies,  the
Committee has  access  to  compensation surveys  for  regional  high  technology
companies  (which compete with ALZA in  the recruitment of senior personnel) and
national pharmaceutical industry  compensation information.  The Committee  also
consults  with ALZA's  Senior Director of  Compensation and  Benefits. Set forth
below is  the  report of  the  Committee  with respect  to  ALZA's  compensation
policies  during 1994 as they affected the company's Chief Executive Officer and
the company's other executive officers.

COMPENSATION POLICIES AFFECTING EXECUTIVE OFFICERS

    ALZA's compensation policies affecting  its executive officers are  designed
to  provide  targeted compensation  levels that  are  competitive with  those of
regional high  technology companies  and national  pharmaceutical companies,  to
assist  the  company  in  attracting  and  retaining  qualified  executives. The
Committee believes that ALZA's compensation  structure has historically been  at
the low end of pharmaceutical companies with respect to salary and bonus payable
to  its  executive officers  generally, and  to its  Chief Executive  Officer in
particular. The S&P Drugs Index, the  industry group included for comparison  in
"Performance Graphs" below, consists of large national pharmaceutical companies,
which have been used as a reference in setting salaries of ALZA's executives.

    ALZA's  compensation policies  take into account  ALZA's overall performance
during  the  prior  year,  as   well  as  the  executive  officers'   individual
achievements  and contributions  to the  company during  the year.  In addition,
ALZA's compensation policies recognize the importance of stock ownership by, and
stock option programs for,  senior executives, in order  to promote identity  of
long-term interests between the executives and the stockholders of ALZA.

    In determining the compensation to be paid to ALZA's executive officers, the
Committee  employs  compensation policies  designed  to align  compensation with
ALZA's overall  business  strategy,  values and  management  initiatives.  These
policies   are  intended  to  (i)  reward  executives  for  long-term  strategic
management  and  the   enhancement  of   stockholder  value;   (ii)  support   a
performance-oriented

                                       7
<PAGE>
environment  that  rewards  achievement of  internal  company  objectives; (iii)
recognize company  performance  compared  to performance  levels  of  comparable
companies;  and (iv) attract and retain  executives whose abilities are critical
to the long-term success and competitiveness of ALZA. As a result,  compensation
consists  of  salary  and bonus,  which  provide current  incentives,  and stock
options, which provide longer-term incentives.

    The key components of executive officer compensation at ALZA are (i) salary,
which  is  based  on  factors  such   as  the  individual  officer's  level   of
responsibility  for meeting the company's financial and strategic objectives and
comparison to similar positions  in the company  and comparable companies;  (ii)
cash bonus awards, which are based on individual performance and the performance
of  ALZA,  measured in  terms of  attainment of  ALZA's financial  and strategic
objectives; and  (iii) stock  option grants,  which are  intended to  align  the
executive  officers'  interests  in  the company's  long-term  success  with the
interests of the company's stockholders, as measured by changes over time in the
company's stock trading price.

    Stock options are an integral part of each executive officer's compensation.
The Committee  believes that  the opportunity  for stock  appreciation,  through
exercise  of stock options that vest over  time, closely aligns the interests of
the executive officers with ALZA's  stockholders. The size of individual  awards
take into account the executive officer's salary, number of unvested options and
past  contributions to ALZA. No one factor  is given special weight, but all are
part of an overall assessment.

RELATIONSHIP OF CORPORATE PERFORMANCE TO COMPENSATION PLANS

    The executive  officers' compensation  during 1994  comprised the  following
elements:  (i)  base salary;  (ii)  limited bonuses  based  on a  combination of
overall company and individual  performance during the  year for officers  other
than those who are also members of the Board of Directors; (iii) grants of stock
options;  and (iv)  interest earned  on compensation  deferred by  the executive
officers under  ALZA's  Executive Deferral  Plans.  Both base  compensation  and
bonuses  take into  consideration the achievement  by ALZA of  the financial and
strategic objectives described above established  by the Board of Directors  for
the  company at  the beginning  of the  year, and  the individual's contribution
toward achieving  those objectives.  The  option grants  take into  account  the
executives'  respective  unvested  options,  salary  and  contributions  to  the
Company.

    ALZA's corporate  performance  measurements  focus  on  both  financial  and
strategic  objectives.  During 1994,  ALZA  substantially achieved  most  of the
strategic objectives set by its Board of Directors, which included:

    - maintaining and expanding ALZA's technological leadership position in drug
      delivery;

    - expanding  ALZA's   product   development/royalty  business   with   other
      pharmaceutical companies;

    - establishing  the infrastructure for ALZA's  expanding current and planned
      direct commercialization activities;

    - obtaining significant royalties from existing client agreements; and

    - accelerating  development   of   products   with   Therapeutic   Discovery
      Corporation.

However, ALZA's financial results for 1994 did not fully meet the objectives set
by the Board.

OTHER COMPENSATION PLANS

    ALZA  has adopted  certain broad-based employee  benefit plans  in which the
executive officers may participate on the same basis as other employees who meet
eligibility criteria, subject to legal limitations  on the benefits that may  be
made available to an individual executive officer. During 1994, these plans that
involved  contributions  by  ALZA  included  an  Employee  Stock  Purchase  Plan
qualified under  Section  423 of  the  Internal  Revenue Code,  under  which  an
individual could elect to purchase up

                                       8
<PAGE>
to  $25,000 of ALZA's  Common Stock at a  price equal to 85  percent of its fair
market value, and the contribution for  the benefit of each employee  (including
executive officers) to the ALZA Retirement Plan (a defined contribution plan) of
an amount based on the employee's base salary and age.

CHIEF EXECUTIVE OFFICER'S COMPENSATION

    Dr.  Ernest Mario, ALZA's  Chief Executive Officer,  received an increase of
10% in salary for 1994 over his 1993  salary rate, for a total annual salary  of
$550,000  (effective March 1, 1994).  He also was granted  an option to purchase
75,000 shares of Common Stock, vesting  in November 1997. The exercise price  of
the  option is $19.25, the fair market value of the Common Stock on the date the
option was granted. The Committee believes that Dr. Mario's salary is on the low
end of salaries for chief executive officers of other technology-based companies
of a similar size and in the same geographic region as ALZA, as well as national
pharmaceutical companies. In addition, in accordance with the recommendation  of
Dr.  Mario, based on the  performance of ALZA during the  year and the fact that
ALZA did not fully achieve the financial objectives established for 1994 by  the
Board of Directors at the beginning of the year, and as agreed by the Committee,
Dr.  Mario did  not receive a  bonus in  1994. Dr. Mario  has, however, provided
important  leadership  in  achieving  the  Company's  long-term  strategic   and
financial  objectives  and will  continue to  provide  this leadership,  and the
option granted in 1994 is intended to support these longer-term goals.

POLICY ON DEDUCTIBILITY OF EXECUTIVE OFFICER COMPENSATION

    Section 162(m) of the  Internal Revenue Code generally  places a $1  million
per  person limit  on the  deduction a  publicly held  corporation may  take for
compensation paid to its chief executive officer and its four other highest paid
executive  officers  unless,   in  general,  the   compensation  is  exempt   as
"performance  based." For stock compensation  to be "performance based," Section
162(m) requires a limit to be set on  the number of options that may be  granted
to employees subject to the deduction cap. The Board of Directors has approved a
limit  of 200,000  as the maximum  number of shares  as to which  options may be
granted to any employee, consultant or director under the 1992 Stock Option Plan
(to be  renamed  the  Amended and  Restated  Stock  Plan upon  approval  of  the
stockholders)  in any  one year period,  and a  limit of 750,000  as the maximum
number of shares as to which options may be granted in connection with an  offer
of  employment. If approved by stockholders,  these limitations will allow gains
realized upon  exercise  of  options  to qualify  as  "performance  based"  and,
therefore,   to  be  excluded  from  compensation  subject  to  the  $1  million
deductibility limit. In general, the  Committee will consider the  deductibility
limits of Section 162(m) in determining executive compensation.

                      COMPENSATION AND BENEFITS COMMITTEE

                          Robert J. Glaser, M.D., Chairman
                                 Dean O. Morton
                                  Isaac Stein

                                       9
<PAGE>
                               PERFORMANCE GRAPHS

FIVE-YEAR TOTAL RETURN

    The  rules  of  the Securities  and  Exchange Commission  require  that ALZA
include in this Proxy Statement  a line-graph presentation comparing  cumulative
stockholder  returns on  an indexed basis  with the  S&P 500 Index  and either a
nationally recognized  industry standard  index or  an index  of peer  companies
selected  by ALZA for the five years  ending December 31, 1994. ALZA has elected
to use  the S&P  Drugs Index  for purpose  of the  performance comparison  which
appears  below. The past performance of ALZA's  Common Stock is no indication of
future performance.

    The graph below has been prepared to give effect to the distribution to ALZA
stockholders on June 11,  1993 of units (the  "Units"), each Unit consisting  of
one  share of Class A Common  Stock of Therapeutic Discovery Corporation ("TDC")
and one warrant to purchase  one-eighth of one share of  ALZA Common Stock at  a
price  of $65 per  share, exercisable at  any time commencing  on the earlier of
June 11, 1996 or the date ALZA exercises its purchase option with respect to all
outstanding Class A Common Stock of TDC and expiring on December 31, 1999.  Each
holder  of Common Stock of ALZA received one Unit for every ten shares of Common
Stock held on  May 28, 1993,  the record  date for the  distribution. The  graph
below assumes that the one-tenth of one Unit received in respect of one share of
ALZA  Common Stock  was sold  on the  distribution date  (June 11,  1993) at the
closing sales price of the Units on  such date ($6.25) and the proceeds  thereof
immediately  applied toward the purchase of 0.0239 shares of ALZA's Common Stock
at a price based  on the closing sales  price of the Common  Stock on such  date
($26.125).

                COMPARISON OF FIVE-YEAR CUMULATIVE TOTAL RETURN
                AMONG ALZA, THE S&P 500 AND THE S&P DRUGS INDEX

EDGAR REPRESENTATION OF DATA POINTS USED IN PRINTED GRAPHIC

<TABLE>
<CAPTION>
             ALZA      S&P DRUGS    S&P 500
<S>        <C>        <C>          <C>
1989             100          100        100
1990          115.95        114.3       96.9
1991          223.93       188.35     126.43
1992          214.25       150.98     136.06
1993          131.86       137.07     149.64
1994           84.01       156.15     151.54
</TABLE>

    The  S&P Drugs Index includes the following:  Eli Lilly and Company, Merck &
Co., Inc., Pfizer, Inc, Schering-Plough Corporation, Syntex Corporation (through
June 6, 1994) and The Upjohn Company.

                                       10
<PAGE>
TEN-YEAR TOTAL RETURN

    The  following graph compares  the cumulative stockholder  returns on ALZA's
Common Stock with the cumulative total return  of the S&P 500 Index and the  S&P
Drugs  Index for  the ten  years ending  December 31,  1994. ALZA  has presented
ten-year data to provide a longer time perspective which is consistent with  the
time  frame for ALZA's business of developing, manufacturing and commercializing
pharmaceutical products. The graph  below has been  prepared in accordance  with
the  same  assumptions used  for  the five-year  graph  above. In  addition, the
ten-year graph  below  has  been  prepared to  give  effect  to  a  subscription
offering,  completed in  1988, to  ALZA stockholders.  Each ALZA  stockholder of
record on November 18,  1988 received one  right for each  share of ALZA  Common
Stock  held. The graph below assumes that one subscription right was sold on the
first day of such  offering (November 22,  1988) at the price  of the rights  on
such  date  ($0.50), and  the proceeds  thereof  immediately applied  toward the
purchase of 0.0212 shares of ALZA's Common Stock at a price based on the closing
sales price of ALZA's Common Stock on such date ($23.625). The past  performance
of ALZA's Common Stock is no indication of future performance.

                 COMPARISON OF TEN-YEAR CUMULATIVE TOTAL RETURN
                AMONG ALZA, THE S&P 500 AND THE S&P DRUGS INDEX

EDGAR REPRESENTATION OF DATA POINTS USED IN PRINTED GRAPHIC

<TABLE>
<CAPTION>
             ALZA      S&P DRUGS    S&P 500
<S>        <C>        <C>          <C>
1984             100          100        100
1985          161.84        144.1     131.73
1986          196.05       199.25     156.32
1987          282.89       220.65     164.53
1988          240.51       256.83     191.86
1989          471.62       384.61     252.66
1990          546.86        439.6      244.8
1991          1056.1       724.38     319.39
1992         1010.41       580.67     343.73
1993          621.55       529.63     378.38
1994          396.03        616.6     383.37
</TABLE>

    The  S&P Drugs Index includes the following:  Eli Lilly and Company, Merck &
Co., Inc., Pfizer, Inc, Schering-Plough Corporation, Syntex Corporation (through
June 6, 1994) and The Upjohn Company.

                                       11
<PAGE>
                           BENEFICIAL STOCK OWNERSHIP

    The following table sets forth  beneficial ownership of ALZA's Common  Stock
as  of March 1, 1995  (except as otherwise noted) (i)  by each person, entity or
"group" of persons or  entities known by  ALZA to be  beneficial owners of  more
than  5% of ALZA's Common Stock, (ii)  by each director, including nominees, and
each of the Named  Executive Officers, and (iii)  by all executive officers  and
directors as a group. Except as described below, each person has sole voting and
dispositive power with respect to the Common Stock described in the table.

<TABLE>
<CAPTION>
                                                                                AMOUNT AND
                                                                                NATURE OF        PERCENT
                                                                                BENEFICIAL         OF
NAME                                                                         OWNERSHIP (1)(2)   CLASS (3)
- ---------------------------------------------------------------------------  ----------------   ---------
<S>                                                                          <C>                <C>
                                                                                10,084,849        12.3%
J.P. Morgan & Co. Incorporated ............................................
 and its subsidiaries
 23 Wall Street
 New York, NY (4)
                                                                                 4,734,235         5.8
Ciba-Geigy Corporation ....................................................
 444 Saw Mill River Rd.
 Ardsley, NY (5)
                                                                                    42,000        --
William G. Davis ..........................................................
                                                                                    60,000        --
Adrian M. Gerber ..........................................................
                                                                                   298,700        --
Martin S. Gerstel .........................................................
                                                                                    16,884        --
Dr. Robert J. Glaser ......................................................
                                                                                   135,000        --
Dr. Ernest Mario ..........................................................
                                                                                    16,000        --
Dean O. Morton ............................................................
                                                                                    45,163        --
Rudolph A. Peterson .......................................................
                                                                                    10,000        --
Dr. Samuel R. Saks ........................................................
                                                                                   430,799        --
Dr. Jane E. Shaw (6) ......................................................
                                                                                    21,608        --
Isaac Stein ...............................................................
                                                                                   153,679        --
Julian N. Stern ...........................................................
                                                                                   225,773        --
Dr. Felix Theeuwes ........................................................
                                                                                   955,950         1.2
Dr. Alejandro Zaffaroni ...................................................
                                                                                 2,794,490         3.4
All Executive Officers and Directors as a group (19 persons) ..............
<FN>
- ------------------------
(1)  Includes  outstanding  stock options,  exercisable on  or before  April 30,
     1995, to  purchase the  number of  shares of  ALZA Common  Stock set  forth
     below:  40,000  for  Mr. Davis;  60,000  for  Mr. Gerber;  115,000  for Mr.
     Gerstel; 6,000 for Dr. Glaser; 115,000 for Dr. Mario; 6,000 for Mr. Morton;
     15,000 for Mr. Peterson; 10,000 for Dr. Saks; 270,000 for Dr. Shaw;  10,000
     for  Mr. Stein; 46,000 for Mr. Stern;  42,000 for Dr. Theeuwes; and 857,400
     for all executive officers and directors as a group.
(2)  Excludes  shares  covered  by   outstanding  warrants,  each  to   purchase
     one-eighth  of one share of ALZA Common Stock  at a price of $65 per share,
     exercisable at any time commencing on the  earlier of June 11, 1996 or  the
     date  ALZA exercises  its purchase option  with respect  to all outstanding
     Class A Common Stock of TDC and expiring on December 31, 1999.
(3)  Percentages are  not  shown  if  holdings  total  less  than  1%  of  total
     outstanding shares.
(4)  Information  is  as of  December  31, 1994  as  provided by  the  holder in
     Amendment No. 8 to its Schedule 13G dated December 31, 1994 and filed  with
     the  Securities and Exchange Commission. As  to such shares, the holder has
     provided the following information: sole voting power -- 5,465,773  shares;
     shared  voting power -- 100,547 shares; sole dispositive power -- 9,925,302
     shares; and shared dispositive power -- 157,347 shares.
(5)  Information is as of  December 31, 1994  as provided by  the holder. As  to
     such   shares,  2,754,820  shares  are   owned  by  Ciba-Geigy  Corporation
     ("Ciba-Geigy") and held  in escrow under  an Escrow Agreement  dated as  of
     March  15, 1991 between  Ciba-Geigy and Chemical Bank,  as Escrow Agent, to
     provide for the exchange of Exchangeable Subordinated Debentures issued  by
     Ciba-Geigy.
(6)  Includes   43,844  shares  allocated  to  Dr.  Shaw's  spouse's  individual
     retirement account.
</TABLE>

                                       12
<PAGE>
                              CERTAIN TRANSACTIONS

    In June 1990, ALZA made a loan in the amount of $80,000 to Adrian M. Gerber,
Executive Vice President, Commercial Development of ALZA, in connection with his
offer of employment and  relocation to California. This  loan was refinanced  by
ALZA  on August 15, 1993. The loan bears interest at the rate of 3.62% per annum
and is payable in full on or before  August 15, 1996. At December 31, 1994,  the
outstanding  principal  and  accrued  interest on  the  loan  totalled $109,861.
Repayment of the  loan is  secured by  a second deed  of trust  on Mr.  Gerber's
residence.

    ALZA  and Dr. Jane E. Shaw have entered into an agreement in connection with
the termination  of  Dr. Shaw's  employment  as President  and  Chief  Operating
Officer  of ALZA. Under  that agreement, Dr.  Shaw will be  a consultant to ALZA
from October 1, 1994 through June 30, 1996, and will receive a consulting fee of
$14,583 per month through June  1996. She has received  a payment of $74,098  in
March  1995,  representing  consulting fees  accrued  through the  time  of such
payment. Under the agreement, all of Dr. Shaw's outstanding stock options (for a
total of 270,000 shares  of ALZA Common Stock)  are fully exercisable, and  will
remain  exercisable  until  30  days after  the  termination  of  the consulting
arrangement. Under  the  agreement,  Dr.  Shaw will  also  receive  a  total  of
$307,432,  of which $74,098 was paid in  March 1995 and the remainder is payable
in 16  equal  monthly  installments  beginning March  31,  1995.  The  agreement
prohibits  Dr. Shaw from providing services  to, or undertaking activities with,
certain competitors of ALZA in the  drug delivery field. The agreement  contains
standard  provisions  such  as  release  of  claims,  continuing confidentiality
obligations and  similar  provisions.  The consulting  fees  and  other  monthly
payments  payable  to Dr.  Shaw  for fiscal  1994  are reported  in  the Summary
Compensation Table above.

    During 1994 ALZA  entered into  an arrangement  with Pharmaceutical  Product
Development  ("PPD"), a contract research organization, pursuant to which PPD is
conducting a  large  multi-site clinical  study  on ALZA's  behalf.  Under  that
arrangement,  ALZA has  paid PPD approximately  $500,000 since  the beginning of
1994, and additional  amounts will be  paid as the  study continues. Dr.  Ernest
Mario,  Co-Chairman,  Chief Executive  Officer and  a director  of ALZA,  is the
non-employee chairman  of  the  board of  directors  of  PPD and  the  owner  of
approximately 10.5% of the stock of PPD.

    ALZA  and Affymax  N.V. ("Affymax") have  a partnership  agreement for joint
development and commercialization of  products incorporating compounds  modified
by  Affymax and ALZA's electrotransport technology. Dr. Alejandro Zaffaroni, Dr.
Robert J. Glaser and Julian N.  Stern, directors and stockholders of ALZA,  were
directors  and stockholders of  Affymax until March 1,  1995. The agreement with
Affymax was approved by a  majority of the directors of  ALZA who were not  also
directors of Affymax.

              APPROVAL OF AMENDMENTS TO THE 1992 STOCK OPTION PLAN

BACKGROUND

    Since  its  inception, ALZA  has granted  options  to employees  to purchase
shares of its Common Stock. ALZA considers its option program to be an important
tool to  help  ALZA  attract,  retain  and  motivate  employees,  directors  and
consultants. The program also generates cash for ALZA when options are exercised
and,  in  the  case  of nonstatutory  stock  options  ("NSOs")  or disqualifying
dispositions of incentive  stock options ("ISOs"),  tax deductions and  possible
tax  credits. The 1992  Stock Option Plan  (the "Plan"), which  provides for the
grant of options to purchase 3,000,000  shares of Common Stock, was approved  by
the stockholders in May 1992 to replace all then-existing stock option plans. As
of  March 1, 1995, employees, directors and consultants held unexercised options
(granted under  the  Plan  and  all predecessor  stock  option  plans)  covering
4,321,819  shares of Common Stock, with an exercise price per share ranging from
$5.25 to $49.25, and 466,318 shares remained available for the grant of  options
under the Plan.

                                       13
<PAGE>
PROPOSAL

    Subject  to stockholder approval,  the Board has  approved the amendment and
restatement of the Plan to effect the following:

        (i) to increase by 3,000,000 the  number of shares of ALZA Common  Stock
    reserved for issuance under the Plan;

        (ii) to limit the number of shares as to which options may be granted to
    any participant under the Plan in any one year period;

       (iii) to provide for grants of restricted stock under the Plan; and

       (iv)  to rename the Plan the  ALZA Corporation Amended and Restated Stock
    Plan.

    INCREASE OF AUTHORIZED SHARES.   Subject to stockholder approval, the  Board
approved  an amendment to the Plan increasing the number of shares available for
issuance under the Plan by 3,000,000 shares of ALZA Common Stock, for a total of
6,000,000 shares. As of  March 1, 1995, only  466,318 shares remained  available
for the grant of options under the Plan. The purpose of the amendment increasing
the  authorized shares is to assure continuity  of ALZA's option program to help
ALZA attract, retain and motivate employees, directors and consultants.

    LIMIT ON NUMBER OF SHARES.  Section  162(m) of the Internal Revenue Code  of
1986,  as amended (the "Code"), enacted in August 1993, limits the deductibility
by public companies of compensation in excess of $1 million per year (subject to
certain exceptions) paid  to certain  executive officers  (generally, the  chief
executive   officer  and  the  other  four  most  highly  compensated  executive
officers). As the limit applies in the  year in which the compensation is  paid,
it  could apply to  income derived from  the exercise of  certain stock options,
measured by the  spread between the  option exercise price  and the fair  market
value of the stock at the time the option is exercised. Options granted prior to
February 17, 1993 are not subject to the deduction limitation under this law.

    "Performance  based"  compensation  is  excluded  from  compensation counted
toward  the  $1  million  deduction   limit  if  certain  conditions  are   met.
Compensation  resulting from  the exercise of  stock options will  be treated as
"performance based" and excluded from the limit on deductibility if, among other
things, the plan  under which the  options are granted  specifies limits on  the
number of shares issuable to any participant under the plan and these limits are
approved by the issuer's stockholders.

    In  order  to  exclude  from the  $1  million  deduction  limit compensation
resulting from the exercise of options granted under the Plan since February 17,
1993, the Board has  adopted, subject to stockholder  approval, an amendment  to
the  Plan to  limit the number  of shares with  respect to which  options may be
granted to (i) no  more than 200,000  shares to any one  participant in any  one
year period, and (ii) no more than 750,000 shares in connection with an offer of
employment.

    RESTRICTED  STOCK.  A restricted stock award is an award of shares of Common
Stock which are subject  to restrictions on transfer  for a period specified  by
the  Compensation  and Benefits  Committee, unless  otherwise determined  by the
Compensation and Benefits  Committee. The holder  must pay par  value ($.01  per
share)  for all restricted stock granted. In  the event the holder of restricted
stock issued under the Plan ceases to be employed by (or to act as a director of
or consultant to) ALZA prior  to the end of  the restriction period, all  shares
still  subject to restriction may  be repurchased by ALZA  for the price paid by
the holder. Before the restriction  period expires, unless otherwise  determined
by the Compensation and Benefits Committee, cash dividends (if any) with respect
to  shares of  restricted stock will  be automatically  reinvested in additional
restricted stock, and dividends  payable in stock  will be paid  in the form  of
restricted stock. The purpose of the amendment to the Plan permitting restricted
stock  awards is to provide greater flexibility to help ALZA attract, retain and
motivate employees, directors and consultants.

                                       14
<PAGE>
    RENAMING THE PLAN.   Due to  the amendment permitting  grants of  restricted
stock  in addition to options under the Plan, the Board has renamed the Plan the
"ALZA Corporation  Amended  and Restated  Stock  Plan", subject  to  stockholder
approval of the amendments.

DESCRIPTION OF THE PLAN

    The  following is a general summary of  the principal provisions of the Plan
as it would be amended and restated upon obtaining stockholder approval for  the
foregoing  proposal. Any stockholder who desires to  review the text of the Plan
may obtain  a  copy  by  writing  to  ALZA,  attention  Corporate  and  Investor
Relations.

    Under  the Plan,  options and restricted  stock may be  granted to employees
(including employees who are officers  or directors) and/or consultants of  ALZA
and its subsidiaries, as recommended from time to time by ALZA's Chief Executive
Officer  or Chief Operating Officer and approved  by the Board or a committee of
the Board to which administration of the Plan has been delegated. The Board  has
delegated administration of the Plan to the Compensation and Benefits Committee.
In addition, options are periodically granted to non-employee directors pursuant
to  the automatic grant provisions of the Plan described below. Employees may be
granted either  ISOs,  NSOs  or restricted  stock.  Non-employee  directors  and
consultants may be granted only NSOs or restricted stock.

    A  typical option would provide its holder with an opportunity to purchase a
specified number of shares of Common Stock  within a ten-year period at a  price
not  less than the  fair market value  of the stock  on the date  the option was
granted. In addition, NSOs could entitle the holder to purchase Common Stock  at
a  price not less than 85% of the fair  market value of the stock on the date of
grant, but no NSOs  have been granted to  date at a price  of less than 100%  of
fair  market value. (The market value of  ALZA Common Stock based on the closing
sales price as reported on  the composite tape on March  1, 1995 was $22.50  per
share.)  No  consideration is  received  by ALZA  for  the granting  of options.
Generally, options  would  not  be  exercisable  at  grant,  but  in  cumulative
increments  over time. An optionee may pay the exercise price in cash, by check,
by surrender of shares of ALZA Common  Stock (but not more frequently than  once
every  six months), by payment in  accordance with a permitted cashless exercise
program or by any other forms of consideration approved by the administrator  of
the Plan.

    Options  normally would be exercisable for three months after the optionee's
employment or other  service with  ALZA terminates and  for one  year after  the
employee's death or permanent and total disability (to the extent exercisable at
the  time of termination, death  or disability), but in  neither case beyond the
original term  of the  option. Options  may be  exercised only  by the  optionee
during  the optionee's lifetime and may be transferred only by will, by the laws
of descent and  distribution, or by  a qualified domestic  relations order.  The
Plan  limits to $100,000 the value of option  stock (measured at the time of the
option grant) with respect to which ISOs granted to any one employee may vest in
any calendar year. In  addition, options covering not  more than 200,000  shares
(750,000 shares in connection with an offer of employment) may be granted to any
one participant in any one year under the Plan.

    The  Plan provides for the one-time grant of a NSO to purchase 20,000 shares
of Common Stock, at fair market value, to each new non-employee director at  the
time  of  an  offer  of  directorship (contingent  upon  the  person  becoming a
director). Each such option vests in five equal annual installments beginning on
the first anniversary of the  date on which the  director first attends a  Board
meeting  following his or her election as a director. The Plan also provides for
the additional grant of a NSO to purchase 10,000 shares of Common Stock, at fair
market value, on each fifth anniversary of the date the director first attends a
Board meeting  during the  director's tenure  as a  non-employee director,  also
vesting  in five equal  installments beginning one  year after the  date of such
additional grant.

    The Plan also provides for awards of restricted stock as described under the
caption "Restricted Stock" above.

                                       15
<PAGE>
    The Plan has a ten-year term. The  Board may terminate or amend the Plan  at
any  time, except that the Plan requires stockholder approval of any increase in
the number of shares as to which options or restricted stock may be granted.  If
not  terminated  earlier, the  Plan would  terminate  on May  3, 2002.  The Plan
requires adjustments in options (including adjustments in the number and type of
securities covered by options  and the exercise price)  and in restricted  stock
awards  in  the event  of  a stock  split,  stock dividend,  recapitalization or
similar event. The  Plan also  provides for  the automatic  acceleration of  the
vesting  of outstanding options  (and the lapse  of restrictions in  the case of
restricted stock) if ALZA undergoes certain fundamental changes in its corporate
structure.

    The benefits or amounts that will be  received by or allocated to the  Named
Executive Officers, all current executive officers and all other employees under
the  Plan will not  change as a result  of the proposed  amendments, and are not
determinable because all awards are made  in the discretion of the  Compensation
and  Benefits Committee.  The benefits  or amounts that  will be  received by or
allocated to ALZA's non-employee directors under  the Plan will not change as  a
result  of the proposed amendments and remain fixed and non-discretionary as set
forth above.

FEDERAL INCOME TAX CONSEQUENCES OF OPTIONS

    The following  is  a general  summary  of  the typical  federal  income  tax
consequences of the issuance and exercise of options under the Plan. It does not
describe state or other tax consequences of the issuance and exercise of options
or the tax consequences of a grant of restricted stock.

    The  grant of an ISO has no federal  income tax effect on the optionee. Upon
exercise, the optionee  does not  recognize income for  "regular" tax  purposes;
however,  the excess of the fair market value  of the stock subject to an option
over the exercise price  of such option (the  "option spread") is includable  in
the  optionee's  "Alternative  Minimum  Taxable  Income"  for  purposes  of  the
Alternative Minimum Tax. If the optionee does not dispose of the stock  acquired
upon  exercise of an ISO  until more than two years  after the option grant date
and more than one year after exercise of  the option, any gain upon sale of  the
shares  will  be a  long-term  capital gain.  If  shares are  sold  or otherwise
disposed of  before  both  of  these  periods  have  expired  (a  "disqualifying
disposition"),  the option spread at the time of exercise of the option (but not
more than the  amount of  gain on  the sale  or other  disposition) is  ordinary
income in the year of such sale or other disposition. If gain on a disqualifying
disposition exceeds the amount treated as ordinary income, the excess is taxable
as capital gain, and as long-term capital gain if the shares have been held more
than  one year after the date of exercise of the option. ALZA is not entitled to
a federal income  tax deduction in  connection with ISOs,  except to the  extent
that the optionee has taxable ordinary income on a disqualifying disposition.

    The  grant of a NSO  has no federal income tax  effect on the optionee. Upon
the exercise of a  NSO, the optionee  has taxable ordinary  income (and ALZA  is
entitled to a corresponding deduction) equal to the option spread on the date of
exercise.  Upon the disposition  of stock acquired  upon exercise of  a NSO, the
optionee recognizes  either  long-term  or  short-term  capital  gain  or  loss,
depending on how long such stock was held.

    In the case of both ISOs and NSOs, special federal income tax rules apply if
ALZA Common Stock is used to pay all or a part of the option price.

BOARD RECOMMENDATION AND VOTE REQUIRED

    The  Board believes that approval  of the proposal to  amend and restate the
Plan will allow ALZA  to continue to provide  incentives to attract, retain  and
motivate  personnel through  the grant  of stock  options and  restricted stock.
ACCORDINGLY, THE BOARD RECOMMENDS THAT STOCKHOLDERS VOTE "FOR" THE AMENDMENT AND
RESTATEMENT OF THE PLAN.  The affirmative vote  of a majority  of the shares  of
Common  Stock present  or represented  and entitled  to vote  at the  meeting is
required to approve the proposal.

                                       16
<PAGE>
                         APPROVAL OF AMENDMENTS TO THE
                       1984 EMPLOYEE STOCK PURCHASE PLAN

BACKGROUND

    The 1984 Employee Stock Purchase  Plan (the "Purchase Plan") was  originally
adopted  by the Board on July 18, 1984 and approved by the stockholders in 1985.
The purpose of  the Purchase  Plan is to  enhance relations  with employees,  to
encourage  and assist employees of ALZA and its subsidiaries to acquire stock in
ALZA at a discount through payroll deductions and to help such employees provide
for their future financial security.

    Since the Purchase  Plan's adoption in  1984, the number  of shares of  ALZA
Common  Stock available for purchase under  the Purchase Plan has been increased
only once, while the number of ALZA employees has more than tripled. As of March
1, 1995, in the  eleven years of  the Purchase Plan  1,002,134 shares have  been
purchased  by employees pursuant  to the Purchase  Plan and it  is expected that
approximately 175,000 shares will be purchased  on the next purchase date  (June
30, 1995), leaving only 372,866 shares available for purchase.

PROPOSAL

    Subject  to stockholder approval,  the Board has  approved the amendment and
restatement of the Purchase Plan to effect the following:

        (i) to increase by 500,000 shares  the number of shares of Common  Stock
    reserved for issuance under the Purchase Plan;

        (ii)  to provide  for the purchase  of shares to  occur semi-annually on
    July 31 and January  31 of each year  (or if any such  day is not a  trading
    day, on the trading day immediately prior to such day);

       (iii)  to permit  enrollment in  the plan  semi-annually on  August 1 and
    February 1 of each  year (or if any  such day is not  a trading day, on  the
    trading day immediately following such day); and

       (iv)  to  rename  the  Purchase Plan  the  ALZA  Corporation  Amended and
    Restated Employee Stock Purchase Plan.

    INCREASE OF AUTHORIZED SHARES.   Subject to stockholder approval, the  Board
approved  an  amendment to  the Purchase  Plan increasing  the number  of shares
available for purchase under the Purchase Plan by 500,000 shares of ALZA  Common
Stock, for a total of 2,050,000 shares available for purchase since the Purchase
Plan  was adopted. The purpose of the amendment increasing the authorized shares
is to assure continuity of the Purchase  Plan in furtherance of the purposes  of
the Purchase Plan described above.

    SEMI-ANNUAL PURCHASES AND ENROLLMENTS.  Currently, the Purchase Plan permits
enrollments  and purchases  only once  per year.  This results  in new employees
being denied participation in  the Purchase Plan  for up to  an entire year  and
locks participating employees into a 12-month investment. Permitting enrollments
and  purchases twice annually will allow  earlier participation by new employees
(which  may  help  ALZA  attract  such  employees)  and  will  provide   greater
flexibility  and liquidity  to existing  employees, which  could encourage wider
participation in the Purchase Plan.

    RENAMING THE PURCHASE PLAN.  Due to the foregoing amendments, the Board  has
renamed  the Purchase Plan  the "ALZA Corporation  Amended and Restated Employee
Stock Purchase Plan", subject to stockholder approval of the amendments.

DESCRIPTION OF THE PURCHASE PLAN

    The following  is a  general  summary of  the  principal provisions  of  the
Purchase  Plan as  it would be  amended and restated  upon obtaining stockholder
approval for the foregoing proposal. Any  stockholder who desires to review  the
text  of  the Purchase  Plan may  obtain a  copy by  writing to  ALZA, attention
Corporate and Investor Relations.

                                       17
<PAGE>
    All employees, including officers and  directors who are employees, who  are
customarily  employed at least  20 hours per  week and five  months or more each
year by ALZA  or any of  its subsidiaries,  are eligible to  participate in  the
Purchase  Plan on the first enrollment date following employment. The enrollment
dates are August 1  and February 1  of each year (or  if any such  day is not  a
trading  day, then  the trading  day immediately  following such  day). The plan
period with respect to the enrollment of any employee ends on the day before the
second  anniversary   of  the   applicable  enrollment   date,  with   automatic
re-enrollment  unless the employee notifies ALZA of  his or her desire not to be
re-enrolled. Participants elect to make contributions by payroll deductions  not
exceeding  15% of "monthly gross pay" (excluding overtime, bonuses and incentive
payments, but  including  contributions  to  deferred  compensation  plans.)  No
participant  may purchase stock under  the Purchase Plan to  the extent that the
purchase would  cause shares  under  that plan  and  all other  "employee  stock
purchase  plans" of ALZA to  accrue at a rate which  exceeds $25,000 of the fair
market value of such  shares for any calendar  year, measured on the  enrollment
date.  Any employee who would hold 5% or more of the total combined voting power
or value of all classes of stock of ALZA immediately after shares are  purchased
under the Purchase Plan is prohibited from participating in the Purchase Plan.

    On  July 31 and January 31 of each year (or if any such day is not a trading
day, on the trading  day immediately prior  to such date),  ALZA will apply  the
funds  then in each  participant's account to  the purchase of  shares of ALZA's
Common Stock. The purchase price is 85% of the lower of the fair market value of
the shares on such date or on the enrollment date for the applicable  enrollment
period.  (The market  value of  ALZA's Common Stock  based on  the closing sales
price as reported on the composite tape on March 1, 1995 was $22.50 per share.)

    The number of shares reserved under the Purchase Plan may be adjusted in the
event of a stock split, stock dividend, recapitalization or other change in  the
capital stock of ALZA.

    The  Purchase Plan is administered by a committee of ALZA employees selected
by the Board. The Purchase Plan may be amended, altered or terminated by ALZA at
any time in its sole discretion. The  benefits or amounts that will be  received
by  or allocated to the Named Executive Officers, all current executive officers
and all other employees under the Purchase  Plan will not change as a result  of
the  proposed amendments and are not  determinable, because all such amounts are
based on the  amount each employee,  in his  or her sole  discretion, elects  to
contribute  to the  Purchase Plan.  Non-employee directors  are not  entitled to
participate in the Purchase Plan.

FEDERAL INCOME TAX CONSEQUENCES

    The Purchase Plan  is intended  to qualify  as an  "employee stock  purchase
plan"  under Section 423 of the Code.  Participants will not have taxable income
for federal income tax purposes either upon  the grant of the right to  purchase
shares  under the  Purchase Plan  or when  the shares  are purchased.  If shares
purchased under the  Purchase Plan are  held for  more than two  years from  the
enrollment  date for the plan  period in which they  were purchased and for more
than one year from the date on which they were purchased, any gain realized on a
sale of such shares in an  amount equal to the lesser  of (i) the excess of  the
sale  price over the amount paid for the  shares, or (ii) 15% of the fair market
value of the shares  on the applicable enrollment  date, is taxable as  ordinary
income.  Any gain  in addition  to such amount  is taxable  as long-term capital
gain. However, if the shares are sold within either the one- or two-year  period
described above, the participant will have taxable ordinary income to the extent
that the fair market value of the shares on the date of purchase is greater than
the  purchase price. The difference, if any, between the sale price and the fair
market value of the shares on the  date of purchase will be long- or  short-term
capital gain or loss, depending on the amount of time the shares have been held.
To  the extent a participant has taxable ordinary income on a disposition of the
shares purchased  under the  Purchase Plan  by  failing to  meet either  of  the
holding  period requirements, ALZA generally will be entitled to a deduction for
federal income tax purposes.

BOARD RECOMMENDATION AND VOTE REQUIRED

    The Board believes that  approval of the proposal  to amend and restate  the
Purchase  Plan  will  allow  ALZA  to  continue  to  provide  to  its  employees
opportunities to invest in ALZA and will provide

                                       18
<PAGE>
greater  flexibility  to  employees  and  management  in  a  changing   economic
environment.  ACCORDINGLY, THE BOARD RECOMMENDS THAT THE STOCKHOLDERS VOTE "FOR"
THE AMENDMENT AND RESTATEMENT  OF THE PURCHASE PLAN.  The affirmative vote of  a
majority  of the shares of  Common Stock present or  represented and entitled to
vote at the meeting is required to approve the proposal.

                              STOCKHOLDER PROPOSAL

    David A.  Dominico, Chairman  of  the Board  of  Trustees of  the  Laborers'
District  Council and Contractors' Pension Fund of Ohio, 7420 Worthington-Galena
Road, Worthington, Ohio, 43805, the beneficial  owner of 3,700 shares of  Common
Stock,  has  given  notice that  he,  or  his representative,  will  present the
proposal set forth below at the Annual Meeting. For the reasons set forth below,
ALZA's Board of Directors recommends a vote "AGAINST" this proposal. The text of
Mr. Dominico's proposal is as follows:

        "RESOLVED: That  the shareholders  of ALZA  Corporation  ("Company")
    recommend  that our Board of Directors take the necessary steps to adopt
    and implement  a  policy  of  cumulative voting  for  all  elections  of
    directors.

                             "SUPPORTING STATEMENT

        "In  the  American  corporate  governance  system,  the  election of
    corporate directors is the primary vehicle for shareholders to influence
    corporate affairs  and exert  accountability on  management. We  believe
    that  the Company's financial  performance is affected  by its corporate
    governance policies and procedures and the level of accountability  they
    impose.  We  believe  cumulative  voting  increases  the  possibility of
    electing independent-minded  directors  that will  enforce  management's
    accountability to shareholders.

        "The   election   of  independent-minded   directors  can   have  an
    invigorating effect  on  the  Board  of  Directors,  fostering  improved
    financial  performance  and  increased  shareholder  wealth.  Management
    nominees often bow to  a Chairman's desires  on business strategies  and
    executive pay without question.

        "Cumulative  voting grants shareholders the number of votes equal to
    the number of shares owned multiplied  by the number of directors to  be
    elected.  The shareholder may cast all of  his or her votes for a single
    director or apportion the votes among the candidates.

        "Currently, the Company's Board of Directors is composed entirely of
    management nominees. Cumulative  voting places  a check  and balance  on
    management nominees by creating more competitive elections.

        "The  argument that the  adoption of cumulative  voting will lead to
    the election of dissidents to the  Board of Directors who represent  the
    special  interests of  a minority  of shareholders  instead of  the best
    interests of all shareholders  is misleading. Legally binding  standards
    of  fiduciary duty compel  all directors, no  matter what combination of
    shareholders  elected  them,  to  act  in  the  best  interest  of   all
    shareholders.  Any director who fails to respect the fiduciary duties of
    loyalty and/or care exposes himself or herself to significant liability.
    Legal recourse is available to correct any breached fiduciary duty.

        "We do not accept  the claim that in  the complex world our  Company
    competes  in, an honest  difference of opinion  over business strategies
    and other policies of  the company makes the  minority view a so  called
    'special  interest'. Quite the contrary, dissent stimulates debate which
    leads  to  thoughtful  action.  Cumulative  voting  will  increase   the
    competitiveness  of director elections. We believe competitive elections
    for director will deter complacency on the Board of Directors, which  in
    turn   will  improve  the  performance   of  our  Company  and  increase
    shareholder wealth.

        "We urge your support for this proposal."

                                       19
<PAGE>
COMMENT AND RECOMMENDATION BY BOARD

    ALZA'S  BOARD  OF  DIRECTORS  OPPOSES THE  STOCKHOLDER  PROPOSAL.  The Board
believes that directors should be chosen for their capability and willingness to
represent all stockholders and ALZA. The Board believes that the current  voting
system,  in which all of the directors are  elected by the holders of a majority
of the shares present  at the annual meeting,  most effectively meets this  goal
and  provides the best  assurance that the  directors' decisions will  be in the
best interests  of  the Company  and  all stockholders.  The  cumulative  voting
suggested  in the stockholder  proposal could allow a  relatively small group of
stockholders to elect one or more  directors. A director elected in this  manner
could represent the special interests of the group electing the director, rather
than  the stockholders as a whole.  Such partisanship among directors and voting
on behalf of special interests could interfere with the effective functioning of
the Board and be  contrary to the  interests of ALZA  and its stockholders.  The
Board  of Directors  believes that  the current  method of  voting for directors
results in a Board that acts for the benefit of ALZA and all its stockholders.

    Finally, under the corporation law of  the State of Delaware, where ALZA  is
incorporated, the action recommended in this proposal could be taken only if the
Board  of  Directors were  to recommend  an amendment  to ALZA's  Certificate of
Incorporation to establish cumulative voting,  and to direct that the  amendment
be  submitted to  a vote  of the  stockholders. The  Board of  Directors has not
recommended and does not recommend such an amendment. Therefore, a vote in favor
of this proposal would be only an advisory recommendation to the Board.

BOARD RECOMMENDATION AND VOTE REQUIRED

    THE BOARD  OF  DIRECTORS THEREFORE  RECOMMENDS  THAT THE  STOCKHOLDERS  VOTE
"AGAINST"  THE STOCKHOLDER PROPOSAL.  The affirmative vote of  a majority of the
shares of Common  Stock present or  represented and  entitled to a  vote at  the
meeting  is required  to approve  the proposal.  Proxies received  will be voted
"AGAINST" the stockholder proposal unless marked to the contrary.

                      RATIFICATION OF INDEPENDENT AUDITORS

    The Board recommends that the stockholders ratify the appointment of Ernst &
Young LLP as independent auditors to audit the financial statements of ALZA  for
the  year  ending December  31, 1995.  Ernst  & Young  LLP (and  its predecessor
company) has acted as ALZA's auditor since ALZA's inception. A representative of
Ernst &  Young  LLP  will  be  present at  the  Annual  Meeting,  will  have  an
opportunity  to make  a statement if  he or  she desires to  do so,  and will be
available to respond to appropriate questions. A favorable vote of a majority of
the shares present and voting  at the Annual Meeting  is required to ratify  the
appointment of Ernst & Young LLP.

                         ANNUAL REPORT TO STOCKHOLDERS

    ALZA's  Annual Report to Stockholders for  the year ended December 31, 1994,
containing the audited consolidated balance sheets  as of December 31, 1994  and
1993 and the related consolidated statements of operations, stockholders' equity
and  cash flows for  each of the past  three fiscal years,  is being mailed with
this Proxy Statement to stockholders entitled to notice of the Annual Meeting.

                             STOCKHOLDER PROPOSALS

    ALZA will,  in future  proxy statements  of the  Board, include  stockholder
proposals  complying with  the applicable rules  of the  Securities and Exchange
Commission and  the  procedures set  forth  in ALZA's  Bylaws.  In order  for  a
proposal  by a stockholder  to be included  in the proxy  statement of the Board
relating to the annual meeting of stockholders to be held in the spring of 1996,
that proposal must be received in writing by the Secretary of ALZA no later than
November 22, 1995.

                                       20
<PAGE>
                                 OTHER MATTERS

    The Board knows of  no other matters  that will be  presented at the  Annual
Meeting.  If, however, any  matter is properly presented  at the Annual Meeting,
the proxy solicited hereby will be voted in accordance with the judgment of  the
proxy holders.

                                          By Order of the Board of Directors,

                                                JULIAN N. STERN
                                                   SECRETARY

Palo Alto, California
March 21, 1995

    YOU ARE CORDIALLY INVITED TO ATTEND THE ANNUAL MEETING IN PERSON. WHETHER OR
NOT  YOU PLAN TO  ATTEND THE MEETING, YOU  ARE REQUESTED TO  SIGN AND RETURN THE
ACCOMPANYING PROXY  CARD  AS  SOON  AS POSSIBLE  IN  THE  ACCOMPANYING  POSTPAID
ENVELOPE. YOUR DOING SO MAY SAVE ALZA THE EXPENSE OF A SECOND MAILING.

                                       21
<PAGE>
                        ALZA CORPORATION
                      AMENDED AND RESTATED
                   EMPLOYEE STOCK PURCHASE PLAN

     1.   PURPOSE.  The ALZA Corporation Amended and Restated Employee Stock
Purchase Plan (the "Plan") is designed to foster continued cordial employee
relations, to encourage and assist employees of ALZA Corporation (the
"Company") and its subsidiaries to acquire stock in the Company and to help
them provide for their future financial security.

     2.   SHARES SUBJECT TO PLAN

          (a)  NUMBER OF SHARES:  The Company has reserved for purchase
under the Plan a total of 2,050,000 shares of its Common Stock (the "Shares").
Shares sold under the Plan may be newly or previously issued shares, but all
shares issued under the Plan, regardless of source, shall be counted against
the 2,050,000 share limitation.  If at any time the available Shares are
oversubscribed, subscriptions shall be reduced proportionately to eliminate
the oversubscription.   Any funds credited to a member that cannot be applied
to the purchase of Shares due to oversubscription shall be promptly refunded
to the member.

          (b)  ADJUSTMENTS:  In the event of any reorganization,
recapitalization, stock split, reserve stock split, stock dividend,
combination of shares, merger, consolidation, offering of rights or other
similar change in the structure of the capital stock of the Company, the
Company may make such adjustment, if any, as it may deem appropriate in the
number, kind and subscription price of the securities available for purchase
under the Plan and in the maximum number of securities that a member is
entitled to purchase.  The Company may make any further adjustments it deems
necessary to insure the qualification of the Plan under Section 423 or any
successor provision of the Internal Revenue Code of 1986, as amended (the
"Code").

     3.   ADMINISTRATION OF THE PLAN.  The Plan shall be administered by
such officers and employees of the Company or other persons as the Board of
Directors of the Company from time to time may select (the "Plan Committee").
All costs and expenses incurred in administering the Plan shall be paid by the
Company, provided that any taxes applicable to a member's participation in the
Plan may be charged to the member by the Company.

          The Plan Committee may make such rules and regulations as it deems
necessary to administer the Plan and to interpret the provisions of the Plan.
Any determination, decision or action of the Plan Committee in connection with
the construction, interpretation, administration or application of the Plan or
any right granted under the Plan shall be final, conclusive and binding upon
all persons.  No member of the Plan Committee shall be liable for any
determination, decision or action made.

     4.   ELIGIBILITY.  Any employee who is customarily employed by the
Company or a subsidiary for 20 hours per week or more and five months or more
in any calendar year (except any employee who would own, directly or
indirectly, five percent or more of the total combined voting power or value
of all classes of stock of the Company or any of its subsidiaries immediately
after Shares are purchased under the Plan) shall be eligible to become a
member of and to participate in the Plan beginning on the first Enrollment
Date following his or her employment with the Company or a subsidiary.

<PAGE>

          For purposes of the Plan, "employee" shall mean any individual who
performs services for the Company or a subsidiary pursuant to an employment
relationship described in Treasury Regulations Section 31.3401(c)-1; and
"subsidiary" shall mean any corporation in an unbroken chain of corporations
beginning with the Company if, as of a given Enrollment Date, each of the
corporations other than the last corporation in the chain owns stock
possessing 50% or more of the total combined voting power of all classes of
stock in one of the other corporations in the chain.

     5.   PARTICIPATION.

          (a)  ENROLLMENT:  Any eligible employee may enroll or re-enroll
in the Plan as of any February 1 or August 1 (or if either such date is not a
trading date, as of the trading date immediately following such date) (each an
"Enrollment Date") for a period of 24 months (an "Offering Period") commencing
on the applicable Enrollment Date and ending on the fourth Purchase Date
following the applicable Enrollment Date.  In order to enroll, an eligible
employee must deliver to the Company a completed and signed "Employee Stock
Purchase Plan Subscription Agreement" indicating the employee's acceptance of
the Plan and agreement to participate in the Plan.  Forms must be received by
the Company no later than an Enrollment Date and shall be effective as of such
Enrollment Date.  Participation in the Plan is entirely voluntary.

          (b)  RE-ENROLLMENT UPON EXPIRATION OF OFFERING PERIOD:  At the
end of a member's then-current Offering Period, the member automatically shall
be enrolled in the next succeeding Offering Period (a "Re-enrollment") unless,
in a manner and at a time specified by the Company, but in no event later than
the day before the first day of such succeeding Offering Period, the member
notifies the Company in writing of the member's desire not to be so enrolled.
Re-enrollment shall be at the same percentage of contributions as the member's
prior participation unless the member by timely written notice changes the
percentage of contribution.  No member shall be automatically re-enrolled
whose participation terminates by operation of Section 9 or who, during the
preceding Offering Period, has reduced his or her percentage of contribution
to 0% or has notified the Company in writing of the member's withdrawal from
participation in the Plan.

          (c)  AUTOMATIC RE-ENROLLMENT ON LOWER PRICE ENROLLMENT DATE:  In
the event that the fair market value of the Company's Common Stock is lower on
any Enrollment Date (the "Lower Price Enrollment Date") than it was on the
Enrollment Date on which a participating member last enrolled in the Plan,
such member shall be deemed to have re-enrolled in the Plan on such Lower
Price Enrollment Date for the next succeeding Offering Period.  A participant
may elect not to re-enroll on a Lower Price Enrollment Date by filing a
written statement declaring such election with the Company prior to such Lower
Price Enrollment Date.

     6.   MEMBER'S CONTRIBUTIONS.  Each member shall make contributions by
payroll deduction of any whole percentage up to 15% of the member's monthly
gross pay, as designated by the member.  "Monthly Gross Pay" shall include
total salary and wages before any tax reduction plan decreases and shall
exclude overtime pay, moving allowances, participation in clinical studies,
bonus payments (including PACE awards), income arising from stock options,
imputed income due to fringe benefits and similar items.  Contributions shall
not be made other than in accordance with this Section 6.

                                      2

<PAGE>

          At any time, a member may elect in writing to decrease the
member's rate of contribution.  An election to decrease the rate of
contribution or to stop contributing totally will take effect on the soonest
practicable payroll date following receipt by the Company of the written
election.  Any election by a member to decrease his or her payroll deductions
to 0% shall be deemed to be an election to withdraw from the Plan effective
immediately following the purchase of Shares on the next Purchase Date.  Such
member's participation in the Offering Period shall continue until the next
Purchase Date; thereafter, the member may enroll on any subsequent Enrollment
Date for a new Offering Period.

          A written election to increase the rate of contribution received
by the Company from a member during the first eighteen months of the then
current Offering Period will become effective on the soonest practicable
payroll date following the Company's receipt of such election and will not
constitute a new enrollment.  An election to increase the rate of contribution
received by the Company from a member during the last six months of the
current Offering Period will become effective on the Enrollment Date
immediately following the Company's receipt of such election and will
constitute a new enrollment.

          Notwithstanding any other provision of the Plan, no member may
receive a right to acquire Shares under the Plan (and all other employee stock
purchase plans of the Company and its subsidiaries that are qualified or
intended to be qualified under Section 423 or any successor provision of the
Code) that accrues at a rate in excess of $25,000 of fair market value of such
Shares for any calendar year (determined as of the Enrollment Date).

          Employee contributions may be commingled with other Company funds
free of any obligation of the Company to pay interest on such funds but shall
be credited to each member as soon as practicable after each withholding.

     7.   PURCHASE RIGHTS

          (a)  GRANT OF PURCHASE RIGHTS.  Enrollment by a member in the
Plan on an Enrollment Date will constitute the grant by the Company to the
Member of rights to purchase Shares under the Plan.  Upon enrollment, unless
otherwise determined by the Plan Committee, a member will become eligible for
the grant of purchase rights for the number of Shares equal to $75,000 divided
by the fair market value of a Share determined at the grant date of such
purchase right.  Any member whose purchase rights expire and who has not
withdrawn from the Plan will automatically be re-enrolled in the Plan and
granted new purchase rights (equal in number to the number of expiring
purchase rights) on the Enrollment Date immediately following the Purchase
Date on which the Member's then current purchase rights expire.  Any member
who is deemed to have re-enrolled on a Lower Price Enrollment Date will be
granted new purchase rights for the number of Shares equal to $75,000 divided
by the fair market value of a Share on the Lower Price Enrollment Date.

          (b)  TERMS AND CONDITIONS OF PURCHASE RIGHTS.  Each purchase
right granted under the Plan shall have the following terms:

                (i) whether or not Shares have been purchased thereunder,
the purchase right will expire on the earliest to occur of (A) the completion
of the purchase of Shares on the last Purchase Date occurring within 24 months
of the Enrollment Date on which such purchase right was granted, or such
shorter period as may be established by the Board of Directors from time to
time prior to an Enrollment Date for all purchase rights to be granted

                                      3

<PAGE>

on such Enrollment Date, or (B) the date on which participation of such
member in the Plan terminates for any reason;

               (ii) payment for Shares purchased under the purchase rights
will be made only through payroll deduction in accordance with Section 6;

              (iii) purchase of Shares upon exercise of the purchase
rights will be accomplished only in installments in accordance with Section 8;

               (iv) the purchase price per Share under the purchase rights
will be determined as provided in Section 8; and

                (v) the purchase rights will in all respects be subject to
the terms and conditions of the Plan, as interpreted by the Plan Committee
from time to time.

     8.   ISSUANCE OF SHARES.  On each January 31 and July 31 (or if either
such date is not a trading date, on the last trading date immediately prior to
such date) during an Offering Period (each a "Purchase Date"), so long as the
Plan shall remain in effect, the Company shall apply the funds then credited
to each member's account to the purchase of whole Shares.  The cost or charge
to each member's account shall be 85% of the fair market value of one share of
ALZA Common Stock on the applicable Enrollment Date or on the Purchase Date,
whichever is lower, as determined in good faith by the Plan Committee,
multiplied by the number of Shares purchased.

          After the purchase of Shares on a Purchase Date, any funds
credited to a member equalling less than the sum required to purchase a whole
Share shall be held for purchases on the next succeeding Purchase Date.  Upon
the effective date of a member's written election to withdraw from
participation in the Plan for the then-current Offering Period, any funds then
credited to the member shall, for purposes of this Section 7, cease to be
credited to such member and shall be refunded to the member.  The Company
shall, promptly after each Purchase Date so long as the Plan is in effect,
issue to the member entitled thereto the Shares purchased by the member under
the Plan.  No member shall have rights as a stockholder of the Company until
such Shares are issued.

     9.   TERMINATION OF MEMBERSHIP.  A member's participation in the Plan
shall terminate, and no Shares may thereafter be purchased by such member
under the Plan, (a) when the member ceases to be employed by the Company and
its subsidiaries for any reason whatsoever, (b) when the member dies, or (c)
90 days after the member ceases to receive any compensation from the Company
and its subsidiaries unless, in the case of (c) above, (i) such cessation is
due to a leave of absence in accordance with policies of the Company or
approved by the person or persons appointed by the Company to administer the
Plan and (ii) the member's right to reemployment is guaranteed by statute or
contract.

     10.  WITHDRAWAL OF FUNDS.  A member may withdraw all or part of the
funds contributed by such member to the Plan at any time prior to the use of
the funds for the purchase of Shares.  A member may make only one withdrawal
of funds per calendar quarter.  The member may not, after any withdrawal,
return any such funds to the Company and require the Company to apply the
funds to the purchase of Shares.

                                      4

<PAGE>

     11.  BENEFICIARY.  Each member may designate in writing one or more
beneficiaries and may, in such member's sole discretion, change such
designation from time to time.  Any such designation shall be effective only
after receipt by the Company and shall be controlling over any disposition by
will or otherwise.

          Upon the death of a member, amounts remaining credited to the
member shall be paid in cash to the beneficiary or beneficiaries designated by
the member or, in the absence of such designation, to the executor,
administrator or other legal representative of the member's estate.  Such
payment shall relieve the Company of further liability under the Plan on
account of the member.  If more than one beneficiary is designated, each
beneficiary shall receive an equal portion of the account unless the member
gave contrary instructions in such designation.

     12.  MODIFICATION, TERMINATION.  The Company expects to continue the
Plan until such time as all of the Shares reserved for purchase under the Plan
have been purchased.  However, the Company reserves the right to amend, alter
or terminate this Plan at any time.  No amendment shall be effective unless,
within one year after it is adopted by the Company's Board of Directors, it is
approved by the holders of a majority of the voting power of the Company's
outstanding shares, if such amendment would:

           (i) increase the number of Shares reserved for purchase under
               the Plan;

          (ii) materially increase the benefits to participants; or

         (iii) materially modify the requirements for participation.

          The Board of Directors may elect to terminate any or all
outstanding enrollments at any time.  In the event the Plan is terminated, the
Board may also elect either to terminate enrollments upon completion of the
purchase of Shares on the next Purchase Date, or to permit enrollments to
expire in accordance with their terms (and participation to continue through
such expiration dates).  If the enrollments are terminated prior to
expiration, any funds contributed to the Plan that have not been used to
purchase Shares shall be returned to the members as soon as administratively
feasible.

          If at any time the Shares available under the Plan are over-
enrolled, enrollments shall be reduced proportionately to eliminate the over-
enrollment.  Any funds that cannot be applied to the purchase of Shares due to
over-enrollment shall be refunded to members as soon as administratively
feasible.

     13.  ASSIGNABILITY OF RIGHTS; CREATION OF LIENS.  No rights of any
member under the Plan shall be assignable by the member, by operation of law
or otherwise, and no person may create a lien on any funds, securities or any
other property, except to the extent that there has been a designation of a
beneficiary or beneficiaries in accordance with the Plan, and except to the
extent permitted by the laws of descent and distribution if such beneficiary
is not designated.  Prior to the purchase of any Shares under the Plan, each
member shall be required to sign a statement to the foregoing effect.  A
member's right to purchase Shares under the Plan shall be exercisable only
during the member's lifetime and only by the member.

                                      5

<PAGE>

     14.  PARTICIPATION IN OTHER PLANS.  Except as provided in Section 6,
nothing in the Plan shall affect an employee's right to participate in and
receive benefits under the then-current provisions of any pension, insurance
or other employee benefit plan or program of the Company or a subsidiary.

     15.  REPORTS.  The Company shall make available to members copies of
all communications with holders of Common Stock, including annual and interim
reports.  In connection with the issuance of Shares under the Plan, the
Company shall provide each member with a summary of such member's total
contributions during the preceding Offering Period, and the number of Shares
purchased, purchase price and the balance of funds, if any, in the member's
account.

     16.  EQUAL RIGHTS AND PRIVILEGES.  All members shall have equal rights
and privileges with respect to the Plan to the extent necessary to cause the
Plan to qualify as an "employee stock purchase plan" within the meaning of
Section 423 or any successor provision of the Code and the regulations
promulgated thereunder.  This Section 16 shall take precedence over all other
provisions of the Plan.

     17.  APPLICABLE LAW.  The interpretation, performance and enforcement
of the Plan shall be governed by the laws of the State of California.

     18.  EFFECTIVE DATE; TRANSITION PROVISIONS .  The Plan amendments
embodied in this Amended and Restated Employee Stock Purchase Plan are
effective July 2, 1995, provided, however, that notwithstanding Sections 5(a)
and 8, (a) no enrollment date will occur on August 1, 1995; (b) the two
Offering Periods existing on the effective date of these amendments (i.e., the
Offering Periods commencing July 1, 1994 and July 1, 1995) will each continue
for 25 months (to July 31, 1996 and July 31, 1997, respectively) and (c) since
no Purchase Date occurred in January of 1995 with respect only to the Offering
Period commencing July 1, 1994 and ending on July 31, 1996, only three
Purchase Dates (June 30, 1995, January 31, 1996 and July 31, 1996) will occur
during such Offering Period.

     18.  APPROVAL.  The Plan was originally approved by the Company's Board
of Directors on July 18, 1984 and by holders of the majority of the voting
power of all outstanding shares of the Company on April 25, 1985.  This
Amended and Restated Plan was approved by the Company's Board of Directors on
February 16, 1995 and by the Company's stockholders on May __, 1995.

                                      6
<PAGE>


                                ALZA CORPORATION
                         AMENDED AND RESTATED STOCK PLAN

     1.   PURPOSE.  The purpose of this ALZA Corporation Amended and Restated
Stock Plan (the "Plan") is to attract, retain and motivate key employees
(including employees who are also directors), directors and consultants of ALZA
Corporation (the "Company") and its subsidiaries by giving them the opportunity
to acquire stock ownership in the Company.  Grants under this Plan may consist
of incentive stock options, intended to satisfy the requirements of Section 422
of the Internal Revenue Code of 1986, as it may be amended from time to time
(the "Code"), or nonstatutory stock options (in either case, where unspecified,
"options").  This Plan also provides for the award of restricted stock.

     2.   EFFECTIVE DATE AND TERM OF PLAN. The effective date of this Plan is
May 4, 1992, the date of the approval of the 1992 Stock Option Plan by the
Company's stockholders. This Plan shall terminate automatically ten (10) years
after its effective date unless terminated earlier by the Board of Directors
(the "Board") under Section 13 hereof.  No grant of options or restricted stock
shall be made after termination of this Plan, but all grants made prior to
termination shall remain in effect in accordance with their terms.

     3.   SHARES SUBJECT TO THE PLAN.

          (a)  NUMBER AND SOURCE OF SHARES.  Subject to the provisions of
Section 9, the total number of shares of stock reserved for grants under this
Plan is 6,000,000 shares of Common


<PAGE>


Stock, $. 01 par value, of the Company (the "Stock").  If any option terminates
or expires without being exercised in full, or if any shares of Stock issued as
restricted stock are forfeited prior to conferring on their holder benefits of
ownership other than voting rights or accumulated dividends that are not
realized, the shares issuable under such option or so forfeited shall become
available again for grant under this Plan.  The shares to be issued hereunder
may consist of authorized and unissued shares or treasury shares.

          (b)  INDIVIDUAL LIMITATION.  The Company may not grant options
covering in the aggregate more than 200,000 shares of Stock (subject to
adjustments and substitutions as required under Section 9 below) to any one
participant in any one-year period, except that, at the time of an offer of
employment, the Company may grant options covering in the aggregate up to
750,000 shares of Stock (subject to adjustments and substitutions as required
under Section 9 below).

     4.   ADMINISTRATION OF THE PLAN.  This Plan shall be administered by the
Board or by a committee that meets the requirements of Rule 16b-3 under the
Securities Exchange Act of 1934 as in effect from time to time (in either case,
the "Administrator").  The Administrator may delegate nondiscretionary
administrative duties to such employees of the Company or a subsidiary as it
deems proper.  The Administrator may also make rules and regulations which it
deems useful to administer this Plan.  Any decision or action of the
Administrator in connection with this Plan or any options or restricted stock
granted or shares of Stock purchased under this

                                    -2-

<PAGE>



Plan shall be final and binding.  No member of the Board shall be liable for any
decision, action or omission respecting this Plan, or any options or restricted
stock granted or shares of Stock issued under this Plan.

     5.   ELIGIBILITY.

          (a) Incentive stock options may be granted under this Plan only to
employees of the Company or a subsidiary, including employees who may also be
officers or directors of the Company or any subsidiary of the Company.
Nonstatutory options and restricted stock may be granted to employees (including
employees who are also directors), directors, consultants and potential
employees (in contemplation of and subject to employment) of the Company or any
subsidiary of the Company; provided, however, that grants to directors who are
not also employees of the Company may be made only in accordance with Section
5(b) below.  Participants in this Plan shall be recommended for grants hereunder
by the Chief Executive Officer or Chief Operating Officer of the Company and
approved by the Administrator.  Determination by the Administrator as to
eligibility shall be conclusive.

          (b)  Notwithstanding any other provision of this Plan, directors who
are not also employees of the Company may receive grants under this Plan only in
accordance with this Section 5(b).  Automatically and in connection with the
offer of directorship to a person who is not an employee of the Company, and
subject to that person becoming a director of the Company within the time period
set forth in the offer, the person shall be granted a nonstatutory option to
purchase 20,000 shares of Stock at the fair market value of the Stock on the
date of the offer.  Such

                                    -3-

<PAGE>


option shall vest in five equal annual increments of 4,000 shares for each
increment, beginning on the first anniversary of the date on which the person
first attends a meeting of the Board following his or her election as a director
(the "Service Date"), and shall be exercisable until the date that is ten (10)
years after the date of grant.  Assuming that the director is a non-employee
director on the fifth anniversary of his or her Service Date, such director
automatically shall be granted on such fifth anniversary of his or her Service
Date a further nonstatutory option to purchase 10,000 shares of Stock at the
fair market value of the Stock on the date of the grant.  Such additional option
shall vest in five equal annual increments of 2,000 shares each, beginning one
year after the date of grant, and shall be exercisable until the date that is
ten (10) years after the date of grant.  Thereafter, on each subsequent fifth
anniversary of his or her Service Date, assuming the director is then a non-
employee director, a further option to purchase an additional 10,000 shares of
Stock automatically shall be granted to such director on the same basis as set
forth in the preceding sentence.  The Service Date for a director who is also an
employee of the Company but who terminates employment with the Company while
remaining a director shall, for purposes of this Section 5(b), be deemed to be
the date on which such director first attends a meeting of the Board following
the termination of his or her employment with the Company.  If such director has
not been granted options to purchase Stock within five years prior to his or her
Service Date, he or she automatically shall be granted a nonstatutory option to
purchase 20,000 shares of Stock on the

                                    -4-

<PAGE>


same basis as set forth above for a grant to a person becoming a director of the
Company; and, thereafter, on each subsequent fifth anniversary of his or her
Service Date, assuming the director is then a non-employee director, a further
option to purchase an additional 10,000 shares of Stock automatically shall be
granted to such director on the same basis as set forth above for further
options.  However, if such director has been granted options to purchase Stock
within five years prior to his or her Service Date, he or she shall
automatically be granted a nonstatutory option to purchase 10,000 shares of
Stock on the same basis as set forth above for further options on the fifth
anniversary of the date of the last grant of options by the Company to such
person prior to the termination of his or her employment with the Company (the
"Initial Grant Date"); and, thereafter, on each subsequent fifth anniversary of
his or her Initial Grant Date, assuming the director is then a non-employee
director, a further option to purchase an additional 10,000 shares of Stock
automatically shall be granted to such director on the same basis as set forth
above for further options.

     6.   OPTIONS.

          (a)  GRANT.  The Administrator may, in its discretion, grant options
under this Plan at any time and from time to time before the expiration of this
Plan.  The Administrator shall specify the date of grant or, if it fails to, the
date of grant shall be the date of the action taken by the Administrator to
grant the option (in either case, the "Grant Date").  If an incentive stock
option is approved in anticipation of employment, the Grant Date shall in any
event not be prior to the date the

                                    -5-

<PAGE>


intended optionee is first treated as an employee of the Company or any
subsidiary for payroll purposes.

          (b)  OPTION AGREEMENTS.  As soon as practicable after the Grant Date,
the Company will provide the optionee a written stock option agreement (the
"Option Agreement"), which designates the option as an incentive stock option or
nonstatutory option and which identifies the Grant Date, the number of shares of
Stock covered by the option, the option price and the terms and conditions for
exercise of the option.

          (c)  TERMS AND CONDITIONS OF OPTIONS.  Options granted under this Plan
shall be subject to the following additional terms and conditions and such other
terms and conditions not inconsistent with this Plan as the Administrator may
impose:

               (i)  EXERCISE OF OPTION.  In order to exercise all or any portion
of an incentive stock option granted under this Plan (or any other option which,
by its terms, so requires), an optionee must remain in the employ of the Company
or a subsidiary of the Company until the date on which the option (or portion
thereof) becomes exercisable (the "Vesting Date").  An option shall be partially
exercisable on or after each Vesting Date with respect to the percentage of
total shares of Stock covered by the option set out in the Option Agreement.

          If an option (or portion thereof) is not exercised on the earliest
Vesting Date on which it becomes exercisable, it may be exercised thereafter at
any time prior to its expiration date; provided, however, that in no event may
an incentive stock option granted under this Plan be exercised more than ten
(10) years from the Grant Date.  If the Company grants an incentive stock

                                    -6-

<PAGE>



option to an optionee who owns, on the Grant Date, directly or by attribution,
stock possessing more than ten percent (10%) of the total combined voting power
of all classes of stock of the company or any subsidiary, the option shall not
be exercisable more than five (5) years after the Grant Date.

          Notwithstanding any other provision of this Plan, to the extent
required by Section 422(d) of the Code, the aggregate value of all shares first
becoming exercisable by an optionee during any year, under all incentive stock
options granted to such optionee covering stock of the Company (or any company
which, at the time of grant, was a parent or subsidiary of the Company), shall
not exceed $100,000 or such other amount as may be in effect from time to time.
If by their terms such incentive stock options, when taken together, would first
become exercisable at a faster rate then, except as otherwise specifically
provided by the Administrator in its discretion, the portion thereof which
exceeds such amount shall be nonstatutory options.  For this purpose, value
shall be the fair market value of the option stock when the options were granted
and options shall be taken into account in the order in which they were granted.
In no event may the operation of this Section 6(c)(i) cause an option to vest
before its terms or, having vested, cease to be vested.

          Nonstatutory options granted to employees under this Plan shall be
exercisable until ten (10) years after the Grant Date, unless the Administrator
shall determine otherwise.

               (ii) OPTION PRICE.  The option price of incentive stock options
shall be at least one-hundred percent (100%) of the

                                    -7-

<PAGE>


fair market value of the shares covered by the option on the Grant Date, as
determined in good faith by the Administrator and, in the case of nonstatutory
options, shall be at least one-hundred percent (100%) of the fair market value
of the shares covered by the option on the Grant Date unless the Administrator
specifically determines otherwise, in which event the option price of such
nonstatutory options shall not be less than eighty-five percent (85%) of the
fair market value of the shares covered thereby on the Grant Date, determined in
the same manner.  If the Company grants an incentive stock option to an optionee
owning on the Grant Date, directly or by attribution, shares possessing more
than ten percent (10%) of the total combined voting power of all classes of
stock of the Company or any subsidiary, the option price shall be at least one-
hundred ten percent (110%) of the fair market value of the shares covered by the
option on the Grant Date determined in the same manner.

               (iii) METHOD OF EXERCISE.  To the extent the right to purchase
shares has accrued, an option (or portion thereof) may be exercised from time to
time in accordance with its terms by written notice from the optionee to the
Company stating the number of shares with respect to which the option is being
exercised and accompanied by payment in full of the exercise price of the
shares.  Payment may be made in cash, by check, or by delivery of shares of
Stock (duly endorsed in favor of the Company or accompanied by a duly endorsed
stock power), by a combination of the above, or any other form of consideration
approved by the Administrator (including payment in accordance with a cashless
exercise program as permitted under Regulation T

                                    -8-
<PAGE>


promulgated by the Federal Reserve Board, as amended from time to time).  Any
shares delivered to the Company as payment upon exercise of an option shall be
valued at their fair market value as of the date of exercise of the option
determined in good faith by the Administrator.  Options may not be exercised by
any optionee by the delivery of shares of stock more frequently than once every
six months.

               (iv) RESTRICTIONS ON OPTION SHARES.  At the time it grants
options under this Plan, the Company may retain for itself (or others) rights to
purchase the shares acquired under the option or impose other restrictions on
the shares.  The terms and conditions of any such rights or other restrictions
shall be set forth in the Option Agreement evidencing the option.

               (v)  NONASSIGNABILITY OF OPTION RIGHTS.  No option shall be
transferable other than by will or by the laws of descent and distribution or a
qualified domestic relations order and, otherwise during the lifetime of an
optionee, only the optionee may exercise an option.

               (vi) EXERCISE AFTER TERMINATION OF SERVICE OR DEATH.  If for any
reason other than permanent and total disability or death, an optionee ceases to
be employed by, or a consultant or director to (if such relationship forms the
sole basis for the grant), the Company or a subsidiary, options held at the date
of such termination (to the extent then exercisable) may be exercised at any
time within three months after the date of such termination (but in no event
after the expiration date of the option as set forth in the Option Agreement).
If an optionee becomes permanently and totally disabled (within the meaning of

                                    -9-

<PAGE>


Section 22(e)(3) of the Code) or dies while employed by, or a consultant or
director to, the Company or a subsidiary, (or, if the optionee dies within the
period that the option remains exercisable after termination of employment,
consultancy or directorship), options then held (to the extent then exercisable)
may be exercised by the optionee, the optionee's personal representative, or by
the person to whom the option is transferred by will or the laws of descent and
distribution, at any time within one year after the disability or death or any
lesser period specified in the Option Agreement (but in no event after the
expiration date of the option as set forth in the Option Agreement).

     7.   RESTRICTED STOCK.

          (a)  GRANT.    The Administrator may grant restricted stock under this
Plan at any time and from time to time before the expiration of this Plan.

          (b)  RESTRICTED STOCK AGREEMENT.  As soon as practicable after the
grant of restricted stock, which in no event shall be later than thirty (30)
days after the grant date of the restricted stock, the Company will provide the
participant with a written restricted stock agreement setting forth the terms
and conditions of the grant (the "Restricted Stock Agreement").

          (c)  PRICE.  Participants awarded restricted stock, within fifteen
(15) days of receipt of the Restricted Stock Agreement, shall pay to the Company
an amount equal to the par value of the Stock subject to the grant.  If such
payment is not made and received by the Company by such date, the grant of
restricted stock shall lapse.

                                    -10-

<PAGE>


          (d)  RESTRICTIONS.  Subject to the provisions of the Plan and the
Restricted Stock Agreement, during a period set by the Administrator, commencing
with, and not exceeding ten (10) years from, the grant date of the restricted
stock (the "Restriction Period"), the participant shall not be permitted to
sell, assign, transfer, pledge or otherwise encumber shares of restricted stock.
Within these limits, the Administrator may provide for the lapse of such
restrictions in installments and may accelerate or waive such restrictions, in
whole or in part, based on service, performance or such other factors or
criteria as the Administrator may determine.

          (e)  DIVIDENDS.  Unless otherwise determined by the Administrator,
cash dividends with respect to shares of restricted stock shall be automatically
reinvested in additional restricted stock, and dividends payable in Stock shall
be paid in the form of restricted stock.

          (f)  TERMINATION.  Except to the extent otherwise provided in the
Restricted Stock Agreement and pursuant to Section 7(d), upon termination of a
participant's employment for any reason during the Restriction Period, all
shares still subject to restriction shall be forfeited by the participant.

     8.   PAYMENT OF TAXES.
          (a)  The exercise of an option (regardless of the form of payment for
exercise of the option) or the transfer or other disposition of restricted stock
shall be conditioned upon payment in cash, or provision satisfactory to the
Administrator for payment to the Company, of any federal and state withholding
taxes which, in the Administrator's judgement, are payable in

                                    -11-

<PAGE>


connection therewith.

          (b)  If and to the extent consented to by the Administrator in its
sole discretion at any time after an election pursuant to this Section 8(b) is
made, a participant may elect in writing to have Stock to be obtained upon
exercise of an option or lapse of restrictions applicable to restricted stock
withheld by the Company on behalf of the optionee to pay the amount of tax
required by law (as determined by the Company) to be withheld.  Any such
election by a participant subject (in the view of the Company) to the "short
swing" profit rules of the Securities and Exchange Commission shall be subject
to the following limitations: (i) such election must be made at least six months
before the date that the amount of tax to be withheld in connection with such
exercise or lapse of restrictions is determined (the "Tax Date") and shall be
irrevocable; or (ii) such election (A) must be made in (or made earlier to take
effect in) any ten-day period beginning on the third business day following the
date of release for publication of the Company's quarterly or annual summary
statements of earnings and (B) the option or restricted stock must be held at
least six months prior to the Tax Date.  Any shares or other securities so
withheld will be valued by the Company as of the Tax Date.  The right to so
withhold shares shall relate separately to each option or any increment thereof.

          (c)  If and to the extent consented to by the Administrator in the
manner described in Section 8(b), an optionee may elect at any time to deliver
previously owned shares of Stock to satisfy the tax obligations in connection
with such

                                    -12-

<PAGE>


options or restricted stock.

     9.   ADJUSTMENT FOR CHANGES IN CAPITALIZATION.  The existence of
outstanding options shall not affect the Company's right to effect adjustments,
recapitalization, reorganizations, or other changes in its or any other
corporation's capital structure or business, any merger or consolidation, any
issuance of bonds, debentures, preferred or prior preference stock ahead of or
affecting the Stock, the dissolution or liquidation of the Company's, or any
other corporation's, assets or business, or any other corporate act whether
similar to the events described above or otherwise.  Subject to Section 10, if
the number of outstanding shares of Stock is increased or decreased in number or
changed into or exchanged for a different number or kind of securities of the
Company or any other corporation by reason of a recapitalization,
reclassification, stock split, combination of shares, stock dividend or other
event, the number and kind of securities with respect to which options or
restricted stock may be granted under this Plan, the individual limitations
under Section 3(b) above, the number and kind of securities as to which
outstanding options may be exercised, the option price at which outstanding
options may be exercised hereunder shall be proportionately adjusted.

     10.  DISSOLUTION, LIQUIDATION, MERGER.  In the event of a dissolution or
liquidation of the Company, a merger or consolidation in which the Company is
not the surviving corporation, a reverse merger in which the Company is the
surviving corporation but in which more than fifty percent (50%) of the shares
of its Stock outstanding before the merger are

                                    -13-

<PAGE>


held, after the merger, by holders different from those immediately prior to the
merger, or a sale of more than eighty percent (80%) of the assets of the
Company, (a) the time at which each outstanding option may be exercised
(subject, in the case of incentive stock options, to the limitations on
exercisability set forth in Section 6(c)(i) of this Plan) shall be accelerated
at a time such that the optionee (upon exercise of the option) would be eligible
to receive the consideration payable to holders of Stock in connection with such
liquidation, dissolution, merger, consolidation, reverse merger or sale, and (b)
the restrictions applicable to any restricted stock shall lapse.

     11.  RIGHTS AS STOCKHOLDER.  Unless the Plan or the Administrator expressly
specify otherwise, a participant shall have no rights as a stockholder with
respect to any shares of Stock covered by a grant hereunder until the date of
issuance (as evidenced by the appropriate entry on the books of the Company or a
duly authorized transfer agent) of a certificate representing the shares of
Stock.  Subject to Sections 9 and 10, no adjustment shall be made for dividends
or other rights for which the record date is prior to the date the certificate
is issued.

     12.  DISQUALIFYING DISPOSITIONS.  If shares of Stock acquired upon exercise
of an incentive stock option are disposed of in a "disqualifying disposition"
(within the meaning of Section 422 of the Code), the holder of the shares shall
notify the Company in writing, within five days after the disposition, of the
date and the terms of such disposition.  In the event of any such disposition,
the holder will comply with any other requirements imposed by the Company in
order to enable the


                                    -14-

<PAGE>


Company to secure the related income tax deduction to which it is entitled.

     13.  TERMINATION OR AMENDMENT.

          (a)  The Board may amend, alter or discontinue this Plan, but no
amendment, alteration or discontinuance shall be made which would impair the
rights of a participant under an outstanding grant without the participant's
consent.  In addition, the Board may not amend or alter the Plan without the
approval of stockholders of the Company entitled to vote at a duly held
stockholders' meeting or by an action by written consent and, if at a meeting, a
quorum of the voting power of the Company is represented in person or by proxy,
where such amendment or alteration would, except as expressly provided in the
Plan, increase the total number of shares reserved for issuance pursuant to
grants under the Plan or in such other circumstances as the Board deems
appropriate to comply with Rule 16b-3 or with Section 422 of the Code or
otherwise.

          (b)  Notwithstanding Section 13(a), except as may be necessary to
comport with changes in the Code, the Employee Retirement Income Security Act,
or the rules thereunder, the Plan shall not be amended more than once every six
months if any such amendment would have the effect of amending in any way the
provisions set forth in Section 5(b) of the Plan relating to automatic stock
option grants to directors.

     14.  PARENT AND SUBSIDIARY.  As used in this Plan, "parent" and
"subsidiary" mean any corporation in an unbroken chain of corporations which
includes the Company if, at the relevant time, each of the corporations other
than the last corporation in the

                                    -15-

<PAGE>


chain owns stock possessing more than fifty percent (50%) of the total combined
voting power of all classes of stock of one of the other corporations in the
chain.

     15.  GOVERNING LAW.  This Plan and the rights of all persons under this
Plan shall be construed in accordance with and under applicable provisions of
the Code and the laws of the State of California.

                                * * * * * * * * *

          The Board adopted the ALZA Corporation 1992 Stock Option Plan on
January 30, 1992 and the stockholders approved it on May 4, 1992.  The Board
amended the ALZA Corporation 1992 Stock Option Plan on February 16, 1995,
renaming it the ALZA Corporation Amended and Restated Stock Plan and the
stockholders approved the amendments on May ___ , 1995.

                             16

<PAGE>


                                ALZA CORPORATION

           THIS PROXY IS SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS

PROXY

     The undersigned hereby appoint(s) ERNEST MARIO, JULIAN N. STERN and BRUCE
C. COZADD, or any of them, each with full power of substitution, the lawful
attorneys and proxies of the undersigned to attend the Annual Meeting of
Stockholders of ALZA CORPORATION to be held on May 11, 1995 and at any
adjournments and postponements thereof, to vote the number of shares the
undersigned would be entitled to vote if personally present, and to vote in
their discretion upon any other business that may properly come before the
meeting.


     THIS PROXY, WHEN PROPERLY EXECUTED, WILL BE VOTED IN THE MANNER DIRECTED BY
THE UNDERSIGNED STOCKHOLDER(S). IF NO DIRECTION IS MADE, THIS PROXY WILL BE
VOTED "FOR" PROPOSALS 1, 2, 3 AND 4 AND "AGAINST" PROPOSAL 5. THIS PROXY MAY BE
REVOKED AT ANY TIME PRIOR TO THE TIME IT IS VOTED BY ANY MEANS DESCRIBED IN THE
ACCOMPANYING PROXY STATEMENT.

                      CONTINUED AND TO BE SIGNED ON REVERSE SIDE   SEE REVERSE
                                                                       SIDE


<PAGE>


  / X / Please mark votes as in this example.

THE BOARD OR DIRECTORS OF ALZA CORPORATION UNANIMOUSLY RECOMMENDS A VOTE "FOR"
PROPOSALS 1, 2, 3 AND 4

1. To elect as Class II Directors:
Nominees: Dr. Robert J. Glaser and Dean O. Morton

           /  / FOR   /  / WITHHOLD

/  /  For both nominees except as noted above

MARK HERE FOR ADDRESS CHANGE AND NOTE BELOW /  /


2. To amend and restate ALZA's 1992 Stock Option Plan.

           /  / FOR   /  / AGAINST   /  / ABSTAIN

3. To amend and restate ALZA's 1984 Employee Stock
   Purchase Plan.

           /  / FOR   /  / AGAINST   /  / ABSTAIN

4. To ratify the appointment of Ernst & Young LLP as
   ALZA's Independent public auditors for fiscal 1995.

           /  / FOR   /  / AGAINST   /  / ABSTAIN


THE BOARD OF DIRECTORS OF ALZA CORPORATION UNANIMOUSLY
RECOMMENDS A VOTE "AGAINST" PROPOSAL 5

5.  Stockholder proposal for cumulative voting.


           /  / FOR   /  / AGAINST   /  / ABSTAIN

Please date and sign exactly as name(s) appear(s) herein.
If shares are held jointly, each holder should sign. Please
give full title and capacity in which signing if not signing
as an individual stockholder.

Signature:                               Date
          ------------------------------     ---------------

Signature:                               Date
          ------------------------------     ---------------


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