MERRILL LYNCH & CO INC
SC 13G/A, 1998-11-19
SECURITY BROKERS, DEALERS & FLOTATION COMPANIES
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EXPIRES:  October 31, 1994
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HOURS PER RESPONSE   14.90


UNITED STATES 

SECURITIES AND EXCHANGE COMMISSION

Washington, DC 20549


SCHEDULE 13G

Under the Securities Exchange Act of 1934

(Amendment No. 2 )*

British Biotech plc
- -------------------------------------------------------------------
(Name of Issuer)


Common Stock
- -------------------------------------------------------------------
(Title of Class of Securities)


11051510
- --------------
(CUSIP NUMBER)

Check the following box if a fee is being paid with this statement.[ ]  (A fee 
is not required only if the filing person: (1) has a previous statement on 
file reporting beneficial ownership of more than five percent of the class of 
securities described in Item 1; and (2) has filed no amendment subsequent 
thereto reporting beneficial ownership of five percent or less of such class.)  
(See Rule 13d-7).

*The remainder of this cover page shall be filled out for a reporting
person's initial filing on this form with respect to the subject class of 
securities, and for any subsequent amendment containing information which 
would alter the disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be 
deemed to be "filed" for the purpose of Section 18 of the Securities 
Exchange Act of 1934 (the "1934 Act") or otherwise subject to the liabilities 
of that section of the Act but shall be subject to all other provisions of the 
Act (however, see the Notes).

**The CUSIP number provided is assigned to the American Depository Shares 
representing the shares of common stock of the Issuer.  The positions reported 
herein by the Reporting Persons are held in the form of ordinary shares of 
common stock. 

<PAGE>

Page 2 of 7 Pages


CUSIP NO.  11051510               13G

1. NAME OF REPORTING PERSON
   S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

Mercury Asset Management Group Ltd.

2. CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* Joint Filing

(a) [ ]
(b) [ ]

3. SEC USE ONLY

4. CITIZENSHIP OR PLACE OF ORGANIZATION
     
England

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH

5. SOLE VOTING POWER

NONE

6. SHARED VOTING POWER

29,698,094

7. SOLE DISPOSITIVE POWER

29,698,094

8. SHARED DISPOSITIVE POWER

NONE

9. AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
NONE (ownership disclaimed pursuant to Section 13d-4 of the 1934 Act)

10. CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
11. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
4.5%

12. TYPE OF REPORTING PERSON*

HC, CO

    *SEE INSTRUCTION BEFORE FILING OUT!



<PAGE>

Page 3 of 7 Pages


CUSIP NO.  11051510                13G

1. NAME OF REPORTING PERSON
   S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

Mercury Asset Management Ltd.

2.  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* Joint Filing 

(a) [ ]
(b) [ ]

3. SEC USE ONLY

4. CITIZENSHIP OR PLACE OF ORGANIZATION

Enland

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH

5. SOLE VOTING POWER

NONE

6. SHARED VOTING POWER

21,380,954

7. SOLE DISPOSITIVE POWER

NONE

8. SHARED DISPOSITIVE POWER

21,380,954

9. AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

21,380,954

10. CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
11. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

4.5%

12. TYPE OF REPORTING PERSON*

IA, PN

    *SEE INSTRUCTION BEFORE FILING OUT!

<PAGE>

Page 4 of 7 Pages

		    SCHEDULE 13G


ITEM 1 (a)  Name of Issuer:
	    --------------

	    British Biotech plc (the "Company")

 
ITEM 1 (b)  Address of Issuer's Principal Executive Offices:
	    -----------------------------------------------

	    Watlington Road
	    Cowley Oxfordshire, 0X4 5LY
	  United Kingdom

ITEM 2 (a)  Name of Persons Filing:
	    ---------------------

	    Mercury Asset Management Group Ltd.
	  Mercury Asset Management Ltd.

ITEM 2 (b)  Address of Principal Business Office or, if none, Residence:
	    -----------------------------------------------------------
	
	33 King William Street
      London EC4R9AS
	England

ITEM 2 (c)  Citizenship:
	    -----------
See Item 4 of Cover Pages

ITEM 2 (d)  Title of Class of Securities:
	    ----------------------------

Common Stock

ITEM 2 (e)  CUSIP NUMBER:
		
See Cover Page











<PAGE>

Page 5 of 7 Pages


ITEM 3          
   
Mercury Asset Management Group Ltd. is a parent holding company in accordance 
with section 240.13d-1(b)(ii)(G).  Mercury Asset Management Ltd. is a wholly 
owned subsidiary of Mercury Asset Management Group Ltd. and is a corporation 
primarily engaged in the business of manging portfolio investments for its 
investment clients.


ITEM 4  Ownership
	--------- 
(a)  Amount Beneficially Owned:
	     
   See Item 9 of Cover Pages.

(b)  Percent of Class:

     See Item 11 of Cover Pages

(c)  Number of shares as to which such person has:

     (i)  sole power to vote or to direct the vote:
		 
	  See Item 5 of Cover Pages
		 
    (ii)  shared power to vote or to direct the vote:

	  See Item 6 of the Cover Pages

   (iii)  sole power to dispose of or to direct the disposition of:
			    
	  See Item 7 of Cover Pages

    (iv)  shared power to dispose of or direct the disposition of:

	  See Item 8 of Cover Pages
			


ITEM 5  Ownership of Five Percent or Less of a Class.
	--------------------------------------------

If this statement is being filed to report the fact that as of the date hereof 
the reporting person has ceased to be the beneficial owner of more than five 
percent of the class of securities, check the following:   [X]






<PAGE>

Page 6 of 7 Pages


ITEM 6  Ownership of More than Five Percent on Behalf of Another Person.
	---------------------------------------------------------------

  Not applicable


ITEM 7   Identification and Classification of the Subsidiary Which 
	 ---------------------------------------------------------
  Acquired the Security Being Reported on by the Parent Holding Company.
  ---------------------------------------------------------------------

The relevant subsidiary of Mercury Asset Management Group Ltd. is: Mercury 
Asset Management Ltd., a corporation primarily engaged in business of managing 
portfolio investments for its investment clients, organized under the laws of 
England.


ITEM 8   Identification and Classification of Members of the Group.
	 ----------------------------------------------------------

Not Applicable



ITEM 9  Notice of Dissolution of Group.
	------------------------------

Not Applicable


ITEM 10  Certification
	 -------------

    By signing below each of the undersigned certifies that, to the best of 
    their knowledge and belief, the securities referred to above were acquired 
    and are held in the ordinary course of business and were not acquired and 
    are not held for the purpose of and do not have the effect of changing or 
    influencing the control of the issuer of such securities and were not 
    acquired and are not held in connection with or as a participant in any 
    transaction having such purpose or effect.












<PAGE>

Page 7 of 7 Pages


Signature.
- ---------

    After reasonable inquiry and to the best of my knowledge and belief, each 
    of the undersigned certifies that the information set forth in this 
    statement is true, complete and correct.


Date:  November 19, 1998


Mercury Asset Management Group Ltd.  

/s/ Ira P. Shapiro
- -----------------------------
Name:  Ira P. Shapiro
Title:  Attorney-In-Fact*


Mercury Asset Management Ltd.

/s/ Ira P. Shapiro
- -------------------------
Name:  Ira P. Shapiro
Title Attorney-In-Fact**


- -----------------------------------
*Signed pursuant to a power of attorney, dated November 6, 1998, included as 
exhibit A to this Schedule 13G. 

**Signed pursuant to a power of attorney, dated November 6, 1998, included as 
exhibit B to this Schedule 13G.


EXHIBIT "A"

POWER OF ATTORNEY



The undersigned, Mercury Asset Management Group Ltd, a corporation duly 
organised under the laws of England and Wales, with its principal place of 
business at 33 King William Street, London EC4R 9AS, does hereby make, 
constitute and appoint, Philip L Kirstein, Michael J Hennewinkel, Ira P 
Shapiro and Thomas D Jones, III, acting severally, each of whose address is 
800 Scudders Mill Road, Plainsboro, New Jersey 08536, as its true and lawful 
attorneys-in-fact, for its and in its name, place and stead to execute and 
cause to be filed and/or delivered, as required under Section 13(d) of the 
Securities Exchange Act of 1934 (the "Act") and the regulations thereunder, 
any number, as appropriate, of original, copies or electronic filings of the 
Securities and Exchange Commission Schedule 13D or Schedule 13G Beneficial 
Ownership Reports (together with any amendments and joint filing agreements 
under Rule 13d-1(f)(1) of the Act, as may be required thereto) to be filed 
and/or delivered with respect to any equity security (as defined in Rule 
13d-1(d) under the Act) beneficially owned by the undersigned and which must 
be reported by the undersigned pursuant to Section 13(d) of the Act and the 
regulations thereunder, and generally to take such other actions and perform 
such other things necessary to effectuate the foregoing as fully in all 
respects as if the undersigned could do if personally present.  This Power of 
Attorney shall remain in effect until revoked, in writing by the undersigned. 

IN WITNESS WHEREOF, the undersigned has executed this Power of Attorney this  
6th  day of November, 1998


Mercury Asset Management Group Ltd

By: __/s/ S.J. Baxter______________________________________
Title:  Director


By: _/s/ Ian Barby_______________________________________
Title: Director & Chairman






EXHIBIT "B"

POWER OF ATTORNEY



The undersigned, Mercury Asset Management Ltd, a corporation duly organised 
under the laws of England and Wales, with its principal place of business at 
33 King William Street, London EC4R 9AS, does hereby make, constitute and 
appoint, Philip L Kirstein, Michael J Hennewinkel, Ira P Shapiro and Thomas D 
Jones, III, acting severally, each of whose address is 800 Scudders Mill Road, 
Plainsboro, New Jersey 08536, as its true and lawful attorneys-in-fact, for its 
and in its name, place and stead to execute and cause to be filed and/or 
delivered, as required under Section 13(d) of the Securities Exchange Act of 
1934 (the "Act") and the regulations thereunder, any number, as appropriate, 
of original, copies or electronic filings of the Securities and Exchange 
Commission Schedule 13D or Schedule 13G Beneficial Ownership Reports (together 
with any amendments and joint filing agreements under Rule 13d-1(f)(1) of the 
Act, as may be required thereto) to be filed and/or delivered with respect to 
any equity security (as defined in Rule 13d-1(d) under the Act) beneficially 
owned by the undersigned and which must be reported by the undersigned pursuant 
to Section 13(d) of the Act and the regulations thereunder, and generally to 
take such other actions and perform such other things necessary to effectuate 
the foregoing as fully in all respects as if the undersigned could do if 
personally present.  This Power of Attorney shall remain in effect until 
revoked, in writing by the undersigned. 

IN WITNESS WHEREOF, the undersigned has executed this Power of Attorney this 
6th   day of November, 1998


Mercury Asset Management  Ltd

By: _/s/  David J. Causer_______________________________________
Title:   Director


By: __/s/ Charles Farquharson______________________________________
Title:  Director







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