AQUILA BIOPHARMACEUTICALS INC
8-K, 1998-04-28
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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                     SECURITIES AND EXCHANGE COMMISSION

                           Washington, D.C.  20549

                                _____________

                                  FORM 8-K


                               CURRENT REPORT

                   Pursuant to Section 13 or 15(d) of the
                      Securities Exchange Act of 1934

                                 _____________

                                 April 13, 1998
               Date of report (date of earliest event reported) 


                        Aquila Biopharmaceuticals, Inc.
              (Exact name of Registrant as specified in Charter)



      Delaware                     0-12081              04-3307818
  (State or                    (Commission File       (I.R.S. Employer 
  jurisdiction of                Number)             Identification Number)
  incorporation)


                  365 Plantation Street, Worcester, MA 01605
               (Address of Principal Executive Offices) (Zip Code)

                                 (508) 797-5777
                  (Registrant's Telephone Number including Area Code)

                                Not Applicable
          (Former name or former address, if changed since last report)


Item 2.  Acquisition or Disposition of Assets.

On April 13, 1998, VacTex, Inc. ("VacTex") became a wholly owned subsidiary 
of Aquila Biopharmaceuticals, Inc. (the "Company") by virtue of its merger 
with Aquila Acquisition, Inc., a wholly owned subsidiary of the Company.  
To effect the merger, the Company caused the exchange of 1,150,000 shares 
of the Company's common stock, $.01 par value, and 7% subordinated 
debentures in the aggregate principal amount of $1,300,000 ("Debentures") 
for all of the issued and outstanding capital stock of VacTex.  The amount 
of consideration for the transaction was determined by the Company based 
upon the value to the Company of acquiring the business of VacTex.  

VacTex is a development stage company formed in January 1996 to develop a 
scientific understanding of the CD1 lipid antigen presenting system.  
Through sponsored research arrangements, VacTex has sought to demonstrate 
that the host response to lipid antigens is an important component of the 
immune system.  VacTex' principle asset is a license agreement with Brigham 
& Women's Hospital, Inc. granting to VacTex the exclusive right to make, 
use, sell, distribute and license products relating to the CD1 lipid 
antigen presenting system.


Item 7.  Financial Statements, Pro Forma Financial Information and Exhibits.

(a) Financial Statements of Business Acquired.


                               VACTEX, INC.
                    (A Development Stage Enterprise)

                          FINANCIAL STATEMENTS

               For the years ended DECEMBER 31, 1997 AND 1996

                     REPORT OF INDEPENDENT ACCOUNTANTS


To the Board of Directors and Stockholders of VacTex, Inc.:

We have audited the accompanying balance sheets of VacTex, Inc. (a 
development stage enterprise), as of December 31, 1997 and 1996 and the 
related statements of operations, changes in stockholders' equity, and cash 
flows for the years then ended and cumulative from inception (November 1, 
1995) to December 31, 1997.  These financial statement are the 
responsibility of the Company's management.  Our responsibility is to 
express an opinion on these financial statements based on our audits.

We conducted our audits in accordance with generally accepted auditing 
standards.  Those standards require that we plan and perform the audit to 
obtain reasonable assurance about whether the financial statements are free 
of material misstatement.  An audit includes examining, on a test basis, 
evidence supporting the amounts and disclosures in the financial 
statements.  An audit also includes assessing the accounting principles 
used and significant estimates made by management, as well as evaluating 
the overall financial statement presentation.  We believe that our audits 
provide a reasonable basis for our opinion.

In our opinion, the financial statements referred to above present fairly, 
in all material respects, the financial position of VacTex, Inc. (a 
development stage enterprise), as of December 31, 1997 and 1996 and the 
results of its operations and its cash flows for the years then ended and 
cumulative from inception (November 1, 1995) to December 31, 1997, in 
conformity with generally accepted accounting principles.

The accompanying financial statements have been prepared assuming that the 
Company will continue as a going concern.  As discussed in Note A to the 
financial statements, the Company has incurred losses from operations since 
inception and requires additional financing.  These circumstances raise 
substantial doubt about the Company's ability to continue as a going 
concern.  Management's plans in regard to these matters are also described 
in Note A.  The financial statements do not include any adjustments that 
might result from the outcome of this uncertainty.

/s/ Coopers & Lybrand, L.L.P.
Boston, Massachusetts
March 16, 1998

                              VACTEX, INC.
                    (A Development Stage Enterprise)
                            BALANCE SHEETS

                      December 31, 1997 and 1996

  ASSETS                                          1997            1996
                                                 ______          ______

Current assets:                              $   135,346       1,171,577
Cash and cash equivalents
Interest receivable                                 -              9,350
                                                --------      ----------       
        Total current assets                     135,346       1,180,927
                                                --------       ---------
                Total assets                 $   135,346     $ 1,180,927
                                                ========       =========

                    LIABILITIES AND STOCKHOLDERS' EQUITY

Accounts payable                                   6,455           1,913
Payable to related party (Note D)                 14,519         172,813

Commitments (Notes C and D)

Stockholders' equity (Note C):
Redeemable preferred stock Series A Cumulative
  Convertible, $.01 par value; 2,500,000
  authorized; 2,000,000 shares issued and
  outstanding                                  2,383,586       2,183,586
Common stock, $.01 par value; 5,000,000
  authorized; 935,000 and 785,000
  shares issued and outstanding as of
  December 31, 1997 and 1996, respectively         9,350           7,850
                                                  
Additional paid-in capital                           -               -   
Deficit accumulated during development stage  (2,278,564)     (1,185,235)
                                              -----------     -----------  
Total stockholders' equity                       114,372       1,006,201
                                              -----------     -----------
Total liabilities and stockholders' equity   $   135,346     $ 1,180,927
                                              ===========     ===========

The accompanying notes are an integral part of the financial statements.





                                 VACTEX, INC.
                      (A Development Stage Enterprise)
                          STATEMENTS OF OPERATIONS

           for the years ended December 31, 1997 and 1996 and cumulative 
               from inception (November 1, 1995) to December 31, 1997



                                                              Cumulative
                                                            From Inception
                                                            (November 1,
                                                               1995) to
                                                             December 31,
                                       1997        1996         1997     
                                      ------      ------    --------------
Operating expenses:
        Research and development     (891,160)  $ (992,102)   $(1,883,262)
        General and administrative    (39,238)     (94,044)      (133,806)
                                     ---------   ----------   ------------
          Operating loss             (930,398)  (1,086,146)    (2,017,068)

        Interest income, net           21,949       71,267         93,470 
                                    ----------  -----------    -----------
                Net loss           $ (908,449) $(1,014,879)   $(1,923,598)
                                     =========  ===========    ===========

The accompanying notes are an integral part of the financial statements.

<TABLE>
                               VACTEX, INC.
                       (A Development Stage Enterprise)
               STATEMENTS OF CHANGES IN STOCKHOLDERS' EQUITY
          from inception (November 1, 1995) through December 31, 1997

<CAPTION>

                           Redeemable
                            Series A
                           Cumulative                                      Deficit
                          Convertible                         Additional  Accumulated     Total
                        Preferred Stock      Common Stock       Paid-In       Since     Stockholders'
                         Shares  Amount     Shares   Amount      Capital     Inception      Equity   

<S>                   <C>       <C>         <C>    <C>        <C>         <C>           <C>   
November 1, 1995

Issuance of common stock
   to founders,
   December 1995                            310,000 $  3,100                               $3,100 

Issuance of Series A
   Preferred stock,
   December 1995      1,000,000 $1,000,000                                              1,000,000 

Accretion of redeemable
        stock                        3,283                                $  (3,283)         -   

Net loss                                                                       (270)         (270)
                                                                               -----         -----
Balance December 31,
   1995               1,000,000  1,003,283  310,000    3,100                 (3,553)    1,002,830 

Issuance of common stock
   to BWH (see Note D),
   January 1996                             325,000    3,250                                3,250 

Issuance of common stock 
   to Procept (see Note D),
   March through December 1996              150,000    1,500   $ 13,500                    15,000 

Issuance of Series A
   Preferred stock,
   February 1996      1,000,000  1,000,000                                              1,000,000 

Accretion of redeemable
   stock                           180,303                      (13,500)   (166,803)       -   

Net loss                                                                 (1,014,879)   (1,014,879)
                                                                         -----------   -----------            
Balance December 31,
   1996               2,000,000  2,183,586  785,000    7,850             (1,185,235)    1,006,201 

Issuance of common stock
   to Procept (see
   Note D), March through
   December 1997                            150,000    1,500     13,500                    15,000 

Stock option compensation                                         1,620                     1,620 

Accretion of redeemable stock      200,000                      (15,120)   (184,880)          -   

Net loss                                                                   (908,449)     (908,449)
                                                                           ---------     ---------
Balance December 31,
   1997               2,000,000 $2,383,586  935,000   $9,350        -   $(2,278,564)     $114,372 
                      ========= ==========  =======   ======    =======  ===========     =========
</TABLE>
The accompanying notes are an integral part of the financial statements.



                                 VACTEX, INC.
                      (A Development Stage Enterprise) 
                           STATEMENT OF CASH FLOWS

          for the years ended December 31, 1997 and 1996 and cumulative 
            from inception (November 1, 1995) to December 31, 1997





                                                                    Cumulative
                                                                 From Inception
                                                                   (November 1,
                                                                    1995) to
                                                                   December 31,
                                     1997            1996             1997
                                   ------           -----         --------------
Cash flows for operating
 activities:
  Net loss                     $  (908,449)    $ (1,014,879)      $ (1,923,598)
  Adjustments to reconcile
    net loss to net cash used                        
    for operating activities:                        
  Noncash compensation expense       1,620                               1,620
  Noncash issuance of common stock  15,000           18,250             36,350
  (Decrease)/increase in accounts
     payable                      (153,752)         174,726             20,974
  Decrease/(increase) in
     accounts receivable             9,350           (9,350)               -   
                                  --------       -----------        ----------  
Net cash used for operating
 activities                     (1,036,231)        (831,253)        (1,864,654)
                                -----------      -----------        -----------
Cash flows from financing activities:
  Proceeds from issuance of
  preferred stock                    -            1,000,000          2,000,000
                                 ----------       ---------         ----------
Net cash provided by financing
  activities                         -            1,000,000          2,000,000
                                 ----------      ----------         ----------
Net increase in cash and
  cash equivalents              (1,036,231)         168,747            135,346
                                -----------      ----------         ----------
Cash and cash equivalents,
  at beginning of period         1,171,577        1,002,830               -   
                                -----------      ----------         ----------
Cash and cash equivalents,
  at end of period               $ 135,346       $1,171,577           $135,346
                                ==========       ==========          =========


The accompanying notes are an integral part of the financial statements.



                                VACTEX, INC.
                   (A Development Stage Enterprise)
               NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

A.	Nature of Business:
VacTex, Inc. (the "Company") (a development stage enterprise) is a 
Delaware Corporation which began operations on November 1, 1995, and 
is engaged in performing research in the field of immunology, with 
hopes of producing therapeutic and/or prophylactic vaccines to combat 
worldwide infectious diseases.  Since its inception, the Company has 
devoted substantially all of its efforts establishing a new business 
and to carry on research and development activities.

The Company is subject to risks common to companies in the industry
including, but not limited to, new technological innovations, 
dependence on key personnel, protection of proprietary technology, 
compliance with government regulations, uncertainty of market 
acceptance of products, product liability and the need to obtain 
financing.

The Company's financial statements have been presented on the basis
that it is a going concern, which contemplates continuity of 
operations, realization of assets and the satisfaction of liabilities 
in the normal course of business.  The Company needs to obtain 
additional financing in 1998 to continue operations.  The Company is 
pursuing potential investors, strategic partners, and corporate 
agreements.  There can be no assurance that the Company will achieve 
its 1998 operating plan or that it will be able to obtain additional 
financing to provide the liquidity necessary for the Company to 
continue its operations.  The financial statements do not include any 
adjustments that might result from the outcome of these uncertainties.

B.	Summary of Significant Accounting Policies:

Cash and Cash Equivalents

The Company considers all highly liquid investments with remaining
maturities of three months or less at the time of acquisition to be 
cash equivalents.  At December 31, 1996 cash equivalents include a 
Federal National Mortgage Association discount note with an effective 
yield of 5.22% which matured in 1997.

Concentration of Credit Risk

Cash and cash equivalents are financial instruments which potentially
subject the Company to concentrations of credit risk.  At December 31, 
1997, substantially all of the Company's cash was invested in a single 
financial institution.

Research and Development Expense

Research and development costs are expensed as incurred.

Income Taxes

The Company uses the liability method of accounting for income taxes.
Under the liability method, deferred tax assets and liabilities 
reflect the impact of temporary timing differences between amounts of 
assets and liabilities for financial reporting purposes and such 
amounts as measured by tax laws.  A valuation allowance is required to 
offset any net deferred tax assets if, based upon available evidence, 
it is more likely than not that some or all of the deferred tax assets 
will not be realized.

Estimates

The preparation of financial statements in conformity with generally
accepted accounting principles requires management to make estimates 
and assumptions that affect the reported amounts of assets and 
liabilities, disclosure of contingent assets and liabilities at the 
dates of the financial statements and the reported amounts of revenues 
and expenses during the reporting periods.  Actual results could 
differ from those estimates.

C.	Equity:

Common Stock

The Company has authorized 5,000,000 shares of common stock at a par
value of $.01 per share.  On November 1, 1995, the Company issued 
310,000 shares ("founders shares") to eight individuals pursuant to 
the provisions of a Restricted Stock Purchase Agreement, in exchange 
for services provided by each individual prior to that date.  As of 
December 31, 1997, the Company has 935,000 common shares outstanding.

Preferred Stock

The Company has authorized 2,500,000 shares of Series A Cumulative
Convertible Redeemable Preferred Stock at  a par value of $.01 per 
share.  Dividends on each share of the Series A Preferred Stock accrue 
on a daily basis at the rate of $.10 per annum.  The stock maintains a 
liquidation preference equal to $1.00 per share plus any accrued or 
declared but unpaid dividends.

The Company shall, unless waived by holders of at least 66 2/3% of the
then outstanding shares of Series A Preferred Stock, redeem the 
following portions of the number of shares of Series A Preferred Stock 
from each holder requesting redemption:

                                       Percentage of shares
                                                 of
                 Redemption             Series A Preferred
                   Date                        Stock
                                        Then Outstanding to
                                                be
                                     Redeemed from each holder                
                -----------          -------------------------

              December 31, 2001               33 1/3%                  
              December 31, 2003                 50%              
              December 31, 2004                100%             


The redemption price shall be $1.00 per share plus all accrued and 
unpaid dividends.

1995 Equity Incentive Plan

On December 18, 1995, the Board of Directors approved an equity
incentive plan to attract and retain key employees and consultants.  
Awards under the plan may be for up to 1,000,000 shares of common 
stock.  Stock options may be in the form of Incentive Stock Options 
(granted at fair market value) or Nonqualified Options (at a price 
determined by the Board of Directors), or may be in the form of 
restricted stock.  Stock Appreciation Rights may be issued separately, 
or in tandem with an option.

Pursuant to the provisions of the Equity Incentive Plan (the "Plan"),
on April 4, 1996 and September 18, 1996 the Board of Directors voted 
to grant nonqualified options to certain nonemployees to purchase 
36,000 and 18,000 shares of common stock, respectively, which 
approximates the common stock's fair value.  The options are 
immediately exercisable, are subject to a two-year repurchase 
restriction and have an exercise price of $.10 per share which 
approximates the common stock's fair value. 

Pursuant to the provisions of the Plan, on March 6, 1997 and September
16, 1997 the Board of Directors voted to grant nonqualified options to 
a director and certain nonemployees to purchase 20,000 and 27,000 
shares of common stock, respectively, having an exercise price of $.10 
per share which approximates the common stock's fair value.  The 
options are immediately exercisable, are subject to a two-year 
repurchase restriction and have an exercise price of $.10 per share.

At December 31, 1997 no options have been canceled or forfeited, none
have been exercised and there were 101,000 options outstanding and 
exercisable under the Plan.

The Company applies Accounting Principles Board Opinion 25 and related
interpretations in accounting for its Plan and, accordingly, 
compensation expense of $1,620 has been recorded in the year ended 
December 31, 1997 for options granted to nonemployees.  Had 
compensation expense for employee options been determined based on the 
fair value at the grant date for options granted under the Plan 
consistent with the method of Statement of Financial Accounting 
Standards No. 123 (SFAS 123), "Accounting for Stock-Based 
Compensation," the Company's net loss would have been as follows:

        Net Loss              December 31, 1997          December 31, 1996
        ---------             -----------------        -----------------
        As reported                $(908,449)              $(1,014,879)
        Pro forma                   (908,889)               (1,018,119)


The effects of applying SFAS 123 in this pro forma disclosure are not 
likely to be representative of the effects or reported net income for 
future years.  Additional awards are anticipated in future years.

The fair value of each option grant was estimated on the date of grant
using the minimum value option-pricing model.  In computing these pro 
forma amounts, the Company has used the following weighted average 
assumptions:
                                December 31, 1997       December 31, 1996
                                -----------------       -----------------
      Risk-free interest rate         6.32%                6% - 6.6%
      Dividend yield                   0%                      0%
      Expected option life          4 years                 4 years
      Weighted average grant date
        fair value                    $.06                    $.06

D.	Collaborative Research and Development Agreements:

Procept

In January 1996, VacTex entered into a Sponsored Research Agreement
with Procept, Inc., a biotechnology company, to provide research 
services relating to the development of novel vaccines based on 
discoveries licensed from the Brigham and Women's Hospital and Harvard 
Medical School relative to the CDI system of lipid antigen 
presentation.

Under the Sponsored Research Agreement, Procept will conduct specified
research tasks on behalf of VacTex for which Procept will receive a 
combination of cash and equity in VacTex based on the number of full-
time equivalent employees of Procept engaged in the research, but 
subject to maximum cash and stock limits.  Currently, Procept has 
neither invested cash in, nor transferred technology to VacTex.  At 
any time until the earlier of December 1997 or the termination of the 
Sponsored Research Agreement by VacTex, Procept may exercise an option 
to purchase all of the outstanding capital stock of VacTex at a fixed 
price.  If Procept does not exercise this option, it must issue 
Procept common stock warrants to VacTex or its stockholders to 
purchase an aggregate of 100,000 shares of common stock at an exercise 
price of $3.50 per share.

For the year ended December 31, 1996, VacTex has research and
development expenses totaling $562,500 related to Procept under this 
agreement which consists of $412,500 paid or payable in cash, and the 
issuance of 150,000 shares of VacTex common stock issued and recorded 
at ten cents per share.

For the year ended December 31, 1997, VacTex has research and
development expenses totaling $315,183 related to Procept under this 
agreement which consists of $300,183 paid or payable in cash, and the 
issuance of 150,000 shares of VacTex common stock issued and recorded 
at ten cents per shares.

Brigham and Women's License Agreement

On January 8, 1996 VacTex entered into an exclusive license and
research agreement with Brigham and Women's Hospital ("BWH") who owns 
the patent on certain technology.  BWH wishes to have the vaccine 
perfected and marketed as soon as possible to make them available for 
public use, while VacTex will have the development and marketing 
skills to undertake the development, manufacture, and selling of the 
licensed product.

VacTex agrees to pay BWH the following:
	a)	$10,000 upon execution of the agreement
	b)	$20,000 on or before 1/1/98
	c)	$20,000 on or before 1/1/99
	d)	$20,000 on or before 1/1/00

In addition, VacTex is required to pay BWH a two percent royalty on
the net sales, if any, of licensed products.  In addition to royalty 
payments, VacTex is to pay BWH $100,000 upon the filing of the first 
IND for any licensed product and $500,000 upon approval by the FDA of 
the first NDA for a licensed product.  Also, in addition to $10,000 of 
cash paid, VacTex has issued to BWH 325,000 shares of its Common Stock 
recorded at one cent per share pursuant to the signing of the license 
agreement.  The agreement, unless extended, remains in effect until 
the expiration of the last to expire of the licensed patents or twenty 
years, whichever is longer.  BWH has the right to terminate the 
license at any time after two years from the date of the agreement if 
VacTex is not demonstrably engaged actively pursuing the goals of the 
agreement, defined as VacTex expending $200,000 per year on said 
technology.

Brigham and Women's Research Agreement

VacTex has agreed to pay BWH in support of a two-year funded research
program on February 8, 1996, undertaken by two employees of BWH as 
follows:
       a)      $100,000 upon execution of the research agreement, and;
       b)      $100,000 on the first day of the next seven calendar 
               quarters, for a total payment of $800,000 during the 
               performance period.

For the years ended December 31, 1997 and 1996, VacTex has research
and development expenses totaling $400,000 paid to BWH in cash 
pursuant to this research agreement.

On February 8, 1998, this agreement was amended to extend it until
February 7, 1999.  VacTex has agreed to pay $412,924 to B&W in support 
of a one-year funded research program undertaken by two employees of 
BWH as follows:
        a)      $103,231 upon execution of the amendment (February 8, 1998)
        b)      $103,231 due on May 8, 1998
        c)      $103,231 due on August 8, 1998
        d)      $103,231 due November 8, 1998

BWH can terminate the one-year agreement given thirty days' written
notice if VacTex does not meet its financial obligation.  VacTex can 
terminate the agreement given thirty-day written notice to BWH but 
remains obligated for a twelve-month period to pay salary continuance 
costs to the two BWH employees.

E.	Income Taxes:

Since the Company has incurred net losses since inception, no
provision for income taxes has been recorded.  Deferred income taxes 
consist principally of deferred tax assets relating to net operating 
losses and research and development credits offset by deferred tax 
liabilities relating to deprecation.  The net deferred federal and 
state tax asset is approximately $878,000 for which a full valuation 
allowance has been provided.

At December 31, 1997, the Company had approximately $1,800,000 of net
operating loss carryforwards available for income tax purposes.  These 
net operating loss carryforwards will expire in 2011.  However, 
changes in the Company's ownership as defined by the Internal Revenue 
Code may limit the Company's ability to utilize net operating loss and 
tax credit carryforwards.

(b) Pro Forma Financial Information.

                     Aquila Biopharmaceuticals, Inc.
              Unaudited Pro Forma Condensed Balance Sheets
                        As of December 31, 1997
                            (in thousands)


                               Historical  Historical   Pro Forma     Pro
                                 Aquila      VacTex   Adjustments  Forma Aquila
                               ----------  ---------- -----------  ------------
Cash, cash equivalents
and marketable securities        $16,897   $     135    $      -     $17,032

Total Assets                     $20,667   $     135    $      -     $20,802

Current liabilities              $ 2,417   $      21    $   100 (1)  $ 2,538

Long term obligations            $   364   $      -     $ 1,300 (2)  $ 1,664

Shareholders equity              $17,887   $    114     $ 8,337 (3)  $16,601
                                                        $(9,623)(4)
                                                        $  (114)(5)


(1) To reflect estimated acquisition costs of $100,000.
(2) To reflect the Debentures of $1.3 million.
(3) To record the issuance of 1,150,000 shares of Aquila common stock.
(4) To reflect the write off of the purchase of incomplete technology of 
    $9.6 million.
(5) To reflect the elimination of VacTex equity.

                         Aquila Biopharmaceuticals, Inc.
                  Unaudited Pro Forma Statement of Operations
                     For the Year Ended December 31, 1997
                  (in thousands, except per share amounts)

                               Historical  Historical   Pro Forma     Pro Forma
                                 Aquila      VacTex    Adjustments     Aquila
                               ----------  ----------  -----------   ----------
Revenue                          $  6,928  $      -     $      -     $ 6,928

Operating cost and
  expenses                       $ 10,564  $    930     $      -     $11,494

Other income, net                $  4,370  $     22     $  (91) (1)  $ 4,301

Income/(loss) from
  continuing
  operations                     $    734  $   (908)    $  (91)      $ (265)

Gain on sale                     $    191  $       -    $     -      $   191

Net income/(loss)                $    925  $   (908)    $  (91)      $  (74)

EPS   Basic                      $   0.18  $  (1.08)                 $(0.01)
      Diluted                        0.18     (l.08)                  (0.01)

Shares outstanding                                       
                                                          
      Basic                         5,004       841       1,150 (2)   6,154
                                                          (841) (3) 
      Diluted                       5,142       841       1,150 (2)   6,292
                                                          (841) (3)

(1) To reflect the accrual of interest on the Debentures.
(2) To record the issuance of 1,150,000 shares of Aquila common stock.
(3) To eliminate the VacTex shares outstanding.

(c) Exhibits.

2.1. Agreement and Plan of Merger by and among Aquila 
Biopharmaceuticals, Inc., Aquila Acquisition, Inc. and VacTex, 
Inc. dated April 13, 1998.  The Company will provide the 
Commission with exhibits and schedules to the Agreement and Plan 
of Merger upon request.

4.1 Form of Debenture.

23.1	Consent of Coopers & Lybrand L.L.P.


SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the 
registrant has duly caused this report to be signed on its behalf by the 
undersigned hereunto duly authorized.


                                           AQUILA BIOPHARMACEUTICALS, INC.



                                           By:_/s/James L. Warren__________
						    James L. Warren

Date:_April 22, 1998




                          EXHIBIT 2.1

                AGREEMENT AND PLAN OF MERGER


AGREEMENT AND PLAN OF MERGER dated as of April ___, 1998 by 
and among Aquila Biopharmaceuticals, Inc., a Delaware corporation 
("Aquila"), Aquila Acquisition, Inc., a Delaware corporation and 
a wholly owned subsidiary of Aquila ("Sub") and VacTex, Inc., a 
Delaware corporation ("VacTex") (Sub and VacTex being sometimes 
hereinafter collectively referred to as the "Constituent 
Corporations").

WHEREAS, the Board of Directors of Aquila, Sub, and VacTex, 
deeming it advisable for the respective benefit of Aquila, Sub 
and VacTex and their respective shareholders that VacTex merge 
with Sub on the terms and conditions hereinafter set forth (the 
"Merger"), have approved this Agreement; and

WHEREAS, for federal income tax purposes it is intended that 
the Merger shall qualify as a reorganization within the meaning 
of Section 368 of the Internal Revenue Code of 1986, as amended 
(the "Code") ;

NOW, THEREFORE, in consideration of the mutual covenants and 
agreements set forth herein, the parties agree as follows:


                             ARTICLE I

                            THE MERGER


1.01	The Merger.  Subject to the terms and conditions 
hereof, at the Effective Time (as defined in Section 1.02), Sub 
shall be merged with and into VacTex in accordance with the 
applicable provisions of Delaware General Corporation Law 
("GCL"), the separate existence of Sub shall cease, and VacTex 
shall be the surviving corporation (the "Surviving Corporation") 
in the Merger.  Upon the consummation of the Merger, the 
Surviving Corporation shall thereupon possess all the rights, 
privileges, powers and franchises of each of the Constituent 
Corporations; and all property, real, personal and mixed, and all 
debts due to either of the Constituent Corporations on whatever 
account, as well as all other things in action or belonging to 
either of the Constituent Corporations shall be vested in the 
Surviving Corporation.  All property rights, privileges, powers 
and franchises and all and every other interest shall be 
thereafter as effectually the property of the Surviving 
Corporation as they were of the Constituent Corporations.  All 
rights of creditors and all liens upon any property of either of 
the Constituent Corporations shall be preserved unimpaired, and 
debts, liabilities and duties of each of the Constituent 
Corporations shall be preserved unimpaired; and all debts, 
liabilities and duties of each of the Constituent Corporations 
shall thenceforth attach to the Surviving Corporation and may be 
enforced against it to the same extent as if said debts, 
liabilities and duties had been incurred or contracted by it.

1.02	Effective Time of the Merger.  As soon as practicable 
after satisfaction or waiver of all conditions to the Merger, the 
parties shall cause a certificate of merger (the "Certificate of 
Merger") to be filed and recorded in accordance with Section 
251(c) of the GCL and shall take such further action as may be 
required by law to make the Merger effective.  The Merger shall 
be effective as of the later of the time the Certificate of 
Merger is duly filed with the Secretary of the State of Delaware 
in accordance with Section 103 of the GCL or at such later time 
as is specified in the Certificate of Merger (the "Effective 
Time").


                           ARTICLE II

                  THE SURVIVING CORPORATION


2.01	Certificate of Incorporation.  The certificate of 
incorporation of VacTex, as in effect immediately prior to the 
Effective Time, shall be the certificate of incorporation of the 
Surviving Corporation; provided such certificate shall have been 
amended and restated in its entirety so as to be in substantially 
the form attached hereto as Exhibit A.

2.02	By-Laws.   The bylaws of VacTex as in effect at the 
Effective Time shall be the By-Laws of the Surviving Corporation, 
provided such by-laws shall have been amended and restated in its 
entirety so as to be in substantially the form attached hereto as 
Exhibit B.

2.03	Officers and Directors.  The officers and directors of 
the Surviving Corporation shall be those officers and directors 
listed in Exhibit C and in each case until their successors have 
been elected and qualified or until otherwise provided by law, 
the certificate of incorporation and the by-laws of the Surviving 
Corporation.


                         ARTICLE III

                    CONVERSION OF SHARES


3.01	Conversion of Shares.  At the Effective Time, by virtue 
of the Merger and without any action on the part of the holders 
of the capital stock of the Constituent Corporations: (a) each 
issued and outstanding share of Sub Common stock, par value $.01 
per share, of Sub ("Sub Common Stock") shall be converted into 
and become one fully paid and non assessable share of common 
stock of the Surviving Corporation, (b) all shares of common 
stock, par value $.0l per share, of VacTex (the "VacTex Common 
Stock") and all shares of Series A Cumulative Convertible 
Preferred Stock, par value $.01 per share, of VacTex (the "VacTex 
Preferred Stock") outstanding immediately prior to the Effective 
Time, other than VacTex Dissenting Shares (as defined in Section 
3.05), if any, shall be converted into and exchanged for in the 
aggregate: (i) 1,150,000 shares of common stock, par value $.0l 
per share, of Aquila (the "Aquila Common Stock"), and  (ii) 7% 
Subordinated Debentures of Aquila in the aggregate principal 
amount of $1,300,000 (the "Aquila Debentures").  The Aquila 
Debentures shall be in substantially the form attached hereto as 
Exhibit D.  The Aquila Common Stock and the Aquila Debentures 
shall be allocated among the VacTex stockholders in accordance 
with Schedule 3.01 hereto.  The Aquila Common Stock and the 
Aquila Debentures are sometimes collectively referred to herein 
as the "Merger Consideration."  

3.02	Exchange of Certificates.  Upon surrender of a VacTex 
Common Stock certificate or a VacTex Preferred Stock certificate 
for cancellation, the holder of such certificate shall be 
entitled to receive in exchange therefor a certificate 
representing that number of whole shares of Aquila Common Stock 
and an Aquila Debenture representing the appropriate principal 
amount into which the shares of VacTex Common Stock or the shares 
of VacTex Preferred Stock theretofore represented by such 
certificate so surrendered shall have been converted pursuant to 
the provisions of this Agreement, and the certificate so 
surrendered shall forthwith be cancelled.  Aquila Common Stock 
and Aquila Debentures into which VacTex Common Stock and the 
VacTex Preferred Stock shall be converted in the Merger shall be 
deemed to have been issued at the Effective Time.  

3.03	No Fractional Securities. No certificate or scrip 
representing fractional shares of Aquila Common Stock shall be 
issued upon the surrender for exchange of certificates 
representing VacTex Common Stock or VacTex Preferred Stock.  The 
number of shares of Aquila Common Stock which each holder of 
VacTex Common Stock and/or of VacTex Preferred Stock shall be 
entitled to receive shall be rounded to the nearest whole share.  
Each holder of VacTex Common Stock or VacTex Preferred Stock who 
would be entitled to receive an Aquila Debenture in the principal 
amount of less than $1,000 shall be entitled to receive cash in 
lieu of such Aquila Debenture.

3.04	Closing of VacTex Transfer Books.  At the Effective 
Time, the stock transfer books of VacTex shall be closed and no 
transfer of VacTex Common Stock or VacTex Preferred Stock shall 
thereafter be made.  If, after the Effective Time, certificates 
representing shares of VacTex Common Stock or shares of VacTex 
Preferred Stock are presented to the Surviving Corporation, they 
shall be cancelled and exchanged for certificates representing 
the appropriate Merger Consideration.

3.05	Dissenting Shares.  (a) In the event that appraisal 
rights are available for the shares of VacTex Common Stock under 
Section 262 ("Section 262") of the GCL, shares of VacTex Common 
Stock held by a shareholder who has properly exercised appraisal 
rights with respect thereto in accordance with Section 262 
(collectively, the "VacTex Dissenting Shares") shall not be 
converted into shares of Aquila Common Stock, but each such 
shareholder shall be entitled to receive payment of the fair 
value of such shares in accordance with the provisions of Section 
262, except that any VacTex Dissenting Shares held by a 
shareholder who shall thereafter withdraw, in accordance with 
Section 262, such demand for appraisal or lose the right to such 
payment shall thereupon be deemed to have been converted into, at 
the Effective Time, the right to receive Merger Consideration as 
provided herein.

(b)	VacTex shall give Aquila (i) prompt notice of any 
written demands under Section 262 of the GCL, withdrawal of any 
such demands and any other instruments served pursuant to the GCL 
received by VacTex and (ii) the right to participate in all 
negotiations and proceedings with respect to any demands with 
respect to the VacTex Dissenting Shares.  VacTex shall cooperate 
with Aquila concerning and shall not, except with the prior 
written consent of Aquila, voluntarily make any payment with 
respect to, or offer to settle or settle, any such demands.

3.06	Transfer of Aquila Common Stock and Aquila Debentures.  

Each certificate of Aquila Common Stock and each Aquila 
Debenture issued pursuant to this Agreement shall be stamped or 
otherwise imprinted with a legend in substantially the following 
form mutatis mutandus:  

The shares represented by this certificate have not 
been registered under the Securities Act of 1933, as 
amended, and thus may not be offered for sale, sold, 
transferred or otherwise disposed of unless registered 
under the Securities Act of 1933, as amended, or unless 
an exemption from such registration is available.  

Aquila may order the transfer agent for Aquila Common Stock 
to stop the transfer of any shares of Aquila Common Stock 
acquired pursuant to this Agreement bearing the legend set forth 
herein.

3.07	Rights of Holders of VacTex Common Stock and VacTex 
Preferred Stock.   At and after the Effective Time, persons who 
were holders of VacTex Common Stock or VacTex Preferred Stock 
shall cease to have any rights as stockholders of VacTex except 
for the right to surrender the stockholder's certificate in 
exchange for receipt of the Merger Consideration.

                        ARTICLE IV

           REPRESENTATIONS AND WARRANTIES OF VACTEX


VacTex represents, warrants and covenants to each of Sub and 
Aquila as of the Effective Time and as of the date hereof as set 
forth below.  The information disclosed on any Schedule shall be 
deemed to relate solely to the section of this Article IV to 
which such Schedule relates and shall not be deemed made for 
other sections to which such disclosures may apply unless (i) it 
is readily apparent that such information is clearly applicable 
to another section of this Article IV or (ii) such disclosure is 
cross-referenced in the Schedule(s) relating to such other 
section(s), and, in each such case, only to the extent that the 
applicable information or risk is described.

4.01	Corporate Organization.  VacTex (i) is a corporation 
duly organized, validly existing and in good standing under the 
laws of the State of Delaware, (ii) has all requisite power and 
authority, corporate and otherwise, to own, operate and lease the 
properties and assets it now owns, operates and leases and to 
carry on its business as now being conducted and (iii) is 
qualified or licensed to do business and in good standing in 
every jurisdiction in which the ownership, operation or lease of 
property by it or the conduct of its business requires such 
qualification or licensing, except for such failures, if any, to 
be so qualified and in good standing, which either individually 
or in the aggregate would not have a "Material Adverse Effect" 
(as hereinafter defined).  Material Adverse Effect when used in 
connection with any entity means any change or effect that is 
materially adverse to the business, financial condition, 
operations, properties, assets or liabilities of such entity.  
VacTex has previously delivered to Aquila complete and correct 
copies of its Certificate of Incorporation, as amended, ("VacTex 
Charter") and by-laws ("VacTex By-Laws") as presently in effect, 
and VacTex is not in default in the performance, observation or 
fulfillment of any provision of the VacTex Charter or VacTex By-
Laws.

4.02	Authorization.  VacTex has full corporate power and 
authority to execute and deliver this Agreement and, subject to 
approval of the proposed Merger contemplated by this Agreement by 
VacTex's shareholders, to consummate the transactions 
contemplated hereby.  The Board of Directors of VacTex has duly 
adopted resolutions (a) declaring that the proposed Merger is 
advisable on substantially the terms and conditions set forth in 
this Agreement, (b) authorizing the execution and delivery of 
this Agreement and the consummation of the transactions 
contemplated hereby, (c) directing that the proposed Merger be 
submitted for consideration at a special meeting of VacTex's 
shareholders and (d) recommending that VacTex's shareholders 
approve the proposed Merger; no other corporate proceedings 
(other than the approval of the proposed Merger by the 
shareholders of VacTex) on the part of VacTex are necessary to 
authorize this Agreement or to consummate the transactions 
contemplated hereby.  This Agreement has been duly and validly 
executed and delivered by VacTex and, subject to approval of the 
shareholders of VacTex, this Agreement constitutes (assuming due 
authorization, execution and delivery of this Agreement by Aquila 
and Sub), the valid and binding agreement of VacTex, enforceable 
against VacTex in accordance with its terms.

4.03	Capitalization.  (a) The authorized capital stock of 
VacTex consists of 5,000,000 shares of VacTex Common Stock of 
which 1,035,000 shares are issued and outstanding and 2,500,000 
shares of VacTex Preferred Stock, of which 2,000,000 shares are 
issued and outstanding.  No other class of capital stock is 
issued or outstanding.  All shares of capital stock of VacTex 
which are outstanding as of the date hereof, are duly authorized, 
validly issued, fully paid and nonassessable, and are not subject 
to, nor were they issued in violation of, any preemptive rights. 
Schedule 3.01 contains a true, correct and complete list of each 
person who owns of record or beneficially any of the capital 
stock of VacTex specifying the number of shares and class of 
securities held by each.

(b)	Except as set forth above, on Schedule 3.01 and on 
Schedule 4.03, there are (i) no shares of capital stock or other 
voting securities of VacTex authorized or outstanding, (ii) no 
subscriptions, options, conversion or exchange rights, warrants, 
repurchase or redemption agreements, or other agreements, claims 
or commitments of any nature whatsoever obligating VacTex to 
issue, transfer, deliver or sell, repurchase or redeem or cause 
to be issued, transferred, delivered, sold, repurchased or 
redeemed, additional shares of its capital stock or other 
securities or obligating VacTex to grant, extend or enter into 
any such agreement or commitment; and (iii) there are no voting 
trusts or other agreements or understandings with respect to the 
voting of the capital stock of VacTex or agreements or 
understandings restricting the disposition of the capital stock 
of VacTex to which VacTex is a party or is bound or, to the best 
knowledge of VacTex after due investigation and inquiry, to which 
any other party is bound.  VacTex does not own beneficially any 
shares of capital stock of Aquila.

4.04	Non-Contravention; Consents and Approvals.  Except for 
(a) the filing of the Certificate of Merger and other appropriate 
merger documents, if any, as required by the laws of the State of 
Delaware and (b) those agreements with respect to which VacTex 
shall obtain the consents and modifications from the appropriate 
parties all as set forth on Schedule 4.04 (the "Required 
Consents"), the execution and delivery of this Agreement by 
VacTex and the consummation of the transactions contemplated 
hereby do not and will not (i) violate any provision of the 
VacTex Charter or VacTex By-Laws; (ii) violate any statute, 
ordinance, rule, regulation, order or decree of any court or of 
any public, governmental or regulatory body, agency or authority 
applicable to VacTex or by which any of its properties or assets 
may be bound; (iii) require any filing with, or permit, consent 
or approval of, or the giving of any notice to, any public, 
governmental or regulatory body, agency or authority; or (iv) 
result in a violation of, or constitute (with or without due 
notice or lapse of time or both) a default (or give rise to any 
right of termination, cancellation or acceleration) under, any of 
the terms, conditions or provisions of any note, bond, mortgage, 
indenture, license, franchise, permit, agreement or other 
instrument or obligation to which VacTex is a party, or by which 
VacTex or any of its properties or assets may be bound, excluding 
from the foregoing clauses (ii), (iii) and (iv) violations, 
breaches and defaults, which, and filings, notices, permits, 
consents and approvals the absence of which, in the aggregate, 
would not have a Material Adverse Effect on VacTex or on the 
ability of VacTex to consummate the transactions contemplated 
hereby.

4.05	Equity Ownership.  VacTex does not own, directly or 
indirectly, any capital stock or other equity securities of any 
corporation or have any direct or indirect equity or ownership 
interest in any entity or business.  VacTex is not subject to any 
obligation or requirement to provide funds for or to make any 
investment in the form of a loan, capital contribution or 
otherwise in any entity or business. 

4.06	Financial Statements.  VacTex has previously delivered 
to Aquila (i) the audited financial statements of VacTex as of 
December 31, 1996 and December 31, 1997, including the notes 
thereto, in each case examined by and accompanied by the report 
of independent certified public accountants, (hereinafter 
collectively referred to as the "VacTex Audited Financial 
Statements").  The VacTex Audited Financial Statements have been 
prepared from, and are in accordance with, the books and records 
of VacTex and present fairly the financial position of VacTex as 
of the dates and for the periods indicated, in each case in 
conformity with generally accepted accounting principles, 
consistently applied during such periods, and have been certified 
without qualification by VacTex's independent public accountants 
(except as to the Company's ability to continue as a going 
concern).  The VacTex Audited Financial Statements contain and 
reflect adequate reserves with respect to the contracts and 
commitments for the sale of goods or provision of services which 
are consistent with previous reserves taken for all reasonably 
anticipated material losses and costs and expenses; and the 
amounts shown as accrued for current and deferred income and 
other taxes in the VacTex Audited Financial Statements are 
sufficient for the payment of all accrued and unpaid federal, 
state and local income taxes, interest, penalties, assessments or 
deficiencies applicable to VacTex, whether disputed or not, for 
the applicable period then ended and periods prior thereto.

4.07	Absence of Undisclosed Liabilities.  Except as and to 
the extent reflected in the balance sheet dated as of 
December 31, 1997, included in the VacTex Audited Financial 
Statements (the "VacTex Balance Sheet") or in the notes to the 
VacTex Financial Statements for the fiscal year then ended, 
VacTex had at that date no liabilities or obligations of any 
nature (whether accrued, absolute, contingent or otherwise and 
whether due or to become due), which were material to VacTex.  
Except as set forth on Schedule 4.07, since the date of the 
VacTex Balance Sheet, VacTex has not incurred any liabilities or 
obligations of any nature (whether accrued, absolute, contingent 
or otherwise, and whether due or to become due) which are 
material to VacTex except for those incurred in the ordinary 
course of business and consistent with past practice.

4.08	Absence of Certain Changes.  Since December 31, 1997, 
VacTex has not (i) suffered any Material Adverse Effect or (ii) 
entered into any material transaction or conducted its business 
or operations, other than in the ordinary course of business 
consistent with past practice.

4.09	Legal Proceedings, etc.  (i) There are no suits, 
actions, claims, proceedings, or to the best of VacTex's 
knowledge after due inquiry of its officers, directors and 
employees, investigations or inquiries pending, or threatened 
against, relating to or involving VacTex (or any of its officers 
or directors in connection with the business or affairs of VacTex 
including any claims against officers and directors under which 
such officer or director would be entitled to indemnification 
from VacTex under the provision of the VacTex Charter or the 
VacTex By-Laws) or any properties or rights of VacTex, before any 
court, arbitrator or administrative or governmental body, United 
States or foreign, which if adversely determined would have a 
Material Adverse Effect on VacTex; (ii) there are no such suits, 
actions, claims, proceedings or investigations pending, or, to 
the best of VacTex's knowledge, threatened challenging the 
validity or propriety of the transactions contemplated by this 
Agreement; and (iii) VacTex is not subject to any judgment, 
decree, injunction, rule or order of any court or, to the best of 
VacTex's knowledge after due inquiry, any governmental 
restriction which is reasonably likely to have a Material Adverse 
Effect on VacTex, or which materially adversely affects the 
ability of VacTex to acquire any property or conduct business in 
any area.

4.10	Compliance with Applicable Law.  Except for such 
violations and defaults which in the aggregate would not have a 
Material Adverse Effect on VacTex, (i) VacTex currently holds and 
is in compliance with the terms of all licenses, permits and 
authorizations necessary for the lawful conduct of its business, 
and (ii) VacTex has complied with, and is not in violation of, or 
in default in any respect under, the applicable statutes, 
ordinances, rules, regulations, orders or decrees of all federal, 
state, local and foreign governmental bodies, agencies and 
authorities having, asserting or claiming jurisdiction over it or 
over any part of its operations or assets.

4.11	No Default.  To the best knowledge of VacTex after due 
inquiry (a) VacTex is not in default under any agreement relating 
to indebtedness for borrowed money to which it is a party, which 
default, after notice or the passage of time, or both, would 
permit the acceleration of such indebtedness for borrowed money, 
(b) VacTex is not in default under any contract, lease or other 
instrument or agreement to which it is a party, and (c) VacTex is 
not in default or violation under any decree of any court or any 
foreign, federal, state, municipal or other governmental or 
regulatory department, agency or authority (including, without 
limitation, applicable laws, rules and regulations relating to 
environmental protection, anti-trust, labor and employment, 
improper payments and civil rights) which default or violation 
would have a Material Adverse Effect on VacTex.

4.12	Brokers and Finders.  Neither VacTex nor any of its 
officers, directors or employees has employed any broker or 
finder or incurred any liability for any brokerage fees, 
commissions, finder's fees or similar fees or expenses and no 
broker or finder has acted directly or indirectly for VacTex in 
connection with this Agreement or the transactions contemplated 
hereby.  No investment banking, financial advisor's or similar 
fees have been incurred or are or will be payable by VacTex in 
connection with this Agreement or the transactions contemplated 
hereby.

4.13	Certain Tax Matters.  VacTex has timely filed all 
federal, state, county, local and foreign income and other tax 
returns, reports and declarations which are required by 
applicable law to be filed on or before the Effective Time.  
VacTex has paid or will pay before the Effective Time, or where 
payment is not required to be made, has made or will make 
adequate provisions for the payment of, all material taxes, 
including, but not limited to, income, withholding, unemployment, 
social security, sales and use and personal property taxes, 
interest and penalties due and payable, in respect of any taxable 
period ending on or before the Effective Time.  For purposes of 
the preceding sentence, the Effective Time shall be treated as 
the last day of a taxable period whether or not the Effective 
Time is in fact the last day of such taxable period.  To the best 
knowledge of VacTex after due inquiry, it will not have any 
material liability with respect to any taxes, in excess of the 
amount so paid or the reserves for taxes so established on the 
books of VacTex.  VacTex is not delinquent in the payment of any 
taxes required to be paid by it.  VacTex has not filed a consent 
to the application of Section 341(f) of the Code.

4.14	Employee Benefit Plans.  VacTex has never maintained or 
contributed to any "employee benefit plan" within the meaning of 
Section 3(3) of the Employee Retirement Income Security Act of 
1974, as amended ("ERISA").  VacTex has never maintained or 
contributed to any employee benefit plan that is subject to Title 
IV of ERISA or intended to be qualified under Section 401(a) of 
the Code.  VacTex has never participated in or contributed to a 
"multi-employer plan" within the meaning of Section 4001(a)(13) 
of ERISA.  VacTex has never been related to any trade or business 
(whether or not incorporated) that together with VacTex would be 
deemed to be a "single employer" within the meaning of Section 
4001(b) of ERISA or Section 414(m) of the Code.

4.15	Employee Matters.

(a)	Except as set forth on Schedule 4.15, VacTex is in 
compliance with all federal, state and municipal laws respecting 
employment and employment practices, terms and conditions of 
employment, and wages and hours, and is not engaged in any unfair 
labor practice and there are no arrears in the payment of wages 
or social security taxes; excluding such violations and 
arrearages which in the aggregate would not have a Material 
Adverse Effect on VacTex or on the ability of VacTex to 
consummate the transactions contemplated hereby.

(b)	Except as set forth on Schedule 4.15:

	(i)	none of the employees of VacTex is represented by 
any labor union;

	(ii)	there is no unfair labor practice complaint 
against VacTex pending before the National Labor Relations 
Board or any state or local agency;

	(iii)	there is no pending labor strike or other material 
labor trouble affecting VacTex (including, without 
limitation, any organizational drive);

	(iv)	there is no material labor grievance pending 
against VacTex; 

	(v)	there is no pending representation question 
respecting the employees of VacTex; and 

	(vi)	there are no pending arbitration proceedings 
arising out of or under any collective bargaining agreement 
to which VacTex is a party, or to the best knowledge of 
VacTex any basis for which a claim may be made under any 
collective bargaining agreement to which VacTex is a party.

(c)	Schedule 4.15 sets forth a true, correct and complete 
list of all existing (i) employee benefits programs, arrangements 
or commitments; including, without limitation, insurance 
coverage, workers, compensation, supplemental unemployment 
benefits, vacation benefits, retirement benefits, life, health, 
disability or accident benefits, deferred compensation, incentive 
compensation, tuition assistance plans, cafeteria plans, salary 
reduction arrangements, pension, profit sharing and all other or 
similar programs, arrangements, commitments or policies provided 
by VacTex to its employees and all written employment or 
independent contractor contracts or agreements between VacTex and 
any of its employees, and (ii) VacTex's payroll, including the 
job descriptions and salary or wage rates of each of its 
employees.

(d)	For purposes of this Subsection 4.15, the term 
"employee" shall be construed to include sales agents and other 
independent contractors who spend a majority of their working 
time on VacTex's business.

4.16	Intellectual Properties.  VacTex owns or is licensed to 
use or otherwise has the right to use all patents, trademarks, 
trade names, trade secrets and all technology and inventions, 
know-how and processes material to the business of VacTex.  

(a) 	Schedule 4.16 sets forth (i) a true and complete 
schedule of each patent, invention, industrial model, method, 
process, design and all disclosures, registrations and 
applications for any of the foregoing owned, licensed, or used by 
VacTex; (ii) a true and accurate identification of each business 
name (other than VacTex), trademark, service mark, trade name, 
copyright and all registrations and applications for any of the 
foregoing owned or used by VacTex; and (iii) a true and complete 
list, without extensive or revealing descriptions, of all trade 
secrets of VacTex including all processes, know-how and other 
technical data, (the properties described in subsection (i), (ii) 
and (iii) above are collectively referred to as "VacTex 
Intellectual Properties") and Schedule 4.16 sets forth a true and 
complete list of all contracts and other agreements to which 
VacTex is a party with respect to each such item of VacTex 
Intellectual Property and right thereto.  

(b)	Except for those rights described in Schedule 4.16 
which have been retained by or granted to those parties to the 
contracts set forth in Schedule 4.16, VacTex is the exclusive 
owner of all right, title and interest in and to each of the 
VacTex Intellectual Properties, free and clear of all liens, 
security interests, charges, encumbrances, equities and other 
adverse claims, and except as set forth in Schedule 4.16 and 
Schedule 4.04, VacTex has the full right to consummate the Merger 
without the consent of any party, and all rights of VacTex in and 
to the Intellectual Properties will be unaffected by the 
transactions contemplated by this Agreement.

(c)	All issued patents, copyrights, trademarks, state, 
federal and foreign registrations thereof listed in Schedule 4.16 
have been validly issued and are enforceable and in full force 
and effect and are not subject to any taxes or maintenance fees 
except as set forth on Schedule 4.16.

 (d)	There have not been nor are there presently any claims, 
actions or judicial or other adversary proceedings involving 
VacTex concerning the VacTex Intellectual Properties; there is no 
basis for any such action or proceeding; and no such action or 
proceeding is pending or, to the best knowledge of VacTex, 
threatened.

(e)	Except as set forth on Schedule 4.16, VacTex has the 
full, exclusive and unrestricted right and authority to use each 
and all of the rights and properties referenced in Schedule 4.16 
in connection with the conduct of its business; to the knowledge 
of VacTex, such use does not conflict with, infringe upon, or 
violate any patent or other proprietary or intellectual property 
right of any other person, and, to the knowledge of VacTex, 
VacTex has not infringed and is not now infringing any patent or 
other proprietary right belonging to any other person.  VacTex 
has not given or received any notice or claim from or to any 
third party with respect to any infringement.

(f)	Except as set forth on Schedule 4.16, there are no 
outstanding, and to the best knowledge of VacTex, no threatened 
disputes or disagreements with respect to any of the rights, 
properties, licenses or similar agreements or arrangements 
identified in Schedule 4.16.

(g)	With respect to each trade secret and invention 
disclosure referenced in Schedule 4.16, all documentation with 
respect to such trade secret and such invention disclosure is 
current, accurate, and sufficient in detail and content to 
identify and explain such trade secret and/or such invention 
disclosure, and to allow its full and proper use without reliance 
on the special knowledge or memory of others.

(h)	VacTex has taken all reasonable security measures to 
protect the secrecy, confidentiality and value of its trade 
secrets	and its invention disclosures and patent applications 
and all other proprietary information.

(i) All proprietary information of VacTex is presently 
valid and protectible, and are not part of the public knowledge 
or literature, nor to the best knowledge of VacTex have they been 
used, divulged, or appropriated for the benefit of any person 
other than VacTex or to the detriment of VacTex.

(j)	To the knowledge of VacTex after due inquiry, none of 
the activities of the employees or consultants of VacTex in 
performing services for VacTex violates any agreements or 
arrangements that such employees have with former employees or 
other third parties, including those relating to use of 
confidential information and/or trade secrets.

4.17	Environmental Compliance.

(a)	VacTex has obtained all permits, licenses and other 
authorizations (collectively "VacTex Environmental Permits") 
which are material to, or necessary for, the operation of 
VacTex's business (as previously or currently conducted by 
VacTex) under federal, state and local laws relating to pollution 
or protection of the environment, including laws relating to 
emissions, discharges, releases or threatened release of 
pollutants, contaminants, hazardous or toxic materials, other 
wastes or materials into ambient air, surface water, ground water 
or land, or otherwise relating to pollution control or the 
manufacturing, processing, distribution, use, treatment, storage, 
disposal, transport or handling of pollutants, contaminants, 
hazardous or toxic materials or other wastes or materials 
(collectively "Environmental Laws").  To the best knowledge of 
VacTex after due inquiry of its officers and employees and except 
as set forth in Schedule 4.17, VacTex is in full compliance with 
all terms and conditions of any required VacTex Environmental 
Permits and is also in full compliance with all other 
limitations, restrictions, conditions, standards, prohibitions, 
requirements, obligations, schedules and timetables contained in 
the Environmental Laws or contained in any regulation, code, 
plan, order, decree, judgment, notice or demand letter issued, 
entered, promulgated or approved thereunder which are material 
to, or necessary for, operation of its business.  Except as set 
forth in Schedule 4.17, VacTex has not received any notice of, 
nor is it aware of, any events, conditions, circumstances, 
activities, practices, incidents, actions or plans which may 
interfere with, or prevent continued compliance by Aquila with 
respect to its continuation of the business of VacTex as 
presently conducted with applicable Environmental Laws and VacTex 
Environmental Permits, or which may give rise to any common law 
or legal liability, or otherwise form the basis of any 
nonfrivolous claim, action, suit, proceeding, hearing or 
investigation under applicable Environmental Laws, based on or 
related to the manufacture, processing, distribution, use, 
treatment, storage, disposal, transport, or handling, or the 
emission, discharge, release or threatened release into the 
environment, of pollutant, contaminant, or hazardous or toxic 
material or other waste or material.

(b)	All current VacTex Environmental Permits are listed on 
Schedule 4.17 true copies of which have been previously delivered 
to Aquila.  Except as set forth on Schedule 4.17, all such VacTex 
Environmental Permits are in full force and effect and fully 
paid; VacTex has not received notice of any violation nor, after 
due inquiry, is VacTex aware of any other violation in respect to 
any VacTex Environmental Permit.  No proceeding is pending, or to 
the knowledge of VacTex threatened to revoke or limit any VacTex 
Environmental Permit; and to the best knowledge of VacTex, no 
material capital expenditure will be necessary to maintain such 
compliance.  

4.18	Insurance.  VacTex maintains no insurance coverage, 
except as set forth in Schedule 4.15. 

4.19	Contracts and Commitments.

(a)	Schedule 4.19 contains a true, complete and correct 
list and description of the following material contracts and 
agreements	in force and effect, whether written or oral 
(collectively, the "VacTex Contracts").

	(i)	all loan agreements, indentures, mortgages and 
guaranties to which VacTex is a party by or by which VacTex 
or any of its property is bound;

	(ii)	all pledges, conditional sale or title retention 
agreements, security agreements, equipment obligations, 
personal property leases and lease purchase agreements to 
which VacTex is party or by which VacTex or any of its 
property is bound;

	(iii)	all contracts, agreements, commitments, purchase 
orders or other understandings or arrangements to which 
VacTex is a party or by which VacTex or any of its property 
is bound which (A) involve payments or receipts by VacTex of 
more than $10,000 in the case of any single contract, 
agreement, commitment, understanding or arrangement under 
which full performance (including payment) has not been 
rendered by all parties thereto or (B) which may have a 
Material Adverse Effect on VacTex;

	(iv)	all agency, distributor, sales representative and 
similar agreements to which VacTex is a party;

	(v)	all contracts, agreements or other understandings 
or arrangements between VacTex and any shareholder or 
Affiliate (as defined in Section 7.08) of VacTex;

	(vi)	all leases, whether operating, capital or 
otherwise, under which VacTex is lessor or lessee;

	(vii)	all contracts agreements and other documents or 
information relating to past disposal of waste (whether or 
not hazardous); and

	(viii)	any other material agreement or contract entered 
into by VacTex or by which VacTex or any of its property is 
bound.

(b)	Except as set forth on Schedule 4.19, VacTex is not a 
party or subject to any in force and effect, oral or written:

	(i)	contract or agreement for the purchase by VacTex 
of inventory, supplies, equipment or other real or personal 
property, or the procurement of services, except individual 
purchase orders or aggregate purchase orders to a single 
vendor involving payments of less than $10,000;

	(ii)	lease of equipment, machinery or other personal 
property involving aggregate annual payments in excess of 
$10,000;

	(iii)	contract or agreements for the sale or lease of 
products or furnishing of services by VacTex except 
individual purchase orders, or aggregate purchase orders 
from a single customer, involving payments of less than 
$10,000;

	(iv)	joint venture, partnership or other contract or 
arrangement involving royalties or the sharing of profits;

	(v)	contract or agreement, other than in the ordinary 
course of business, relating to the purchase or acquisition, 
by merger or otherwise, of a significant portion of the 
business, assets or securities of VacTex by any other person 
or of any other person by VacTex;

	(vi)	contract or agreement containing a covenant or 
covenants which purport to limit to a material extent the 
ability or right of VacTex to engage in any lawful business 
activity or compete with any person or entity;

	(vii)	contract or agreement for the borrowing or lending 
of money or the guarantee of the obligations of any other 
person; or

	(viii)	material contract or agreement not otherwise 
described in this Section 4.22 involving payments of $10,000 
or more which is not terminable by and without penalty to 
VacTex within six months after the date of this Agreement.

(c)	Except as set forth on Schedule 4.19:

	(i)	each VacTex Contract is a valid and binding 
agreement of VacTex enforceable against VacTex in accordance 
with its terms, and VacTex does not have any knowledge that 
any VacTex Contract is not a valid and binding agreement of 
the other parties thereto;

	(ii)	VacTex has fulfilled all material obligations 
required pursuant to the VacTex Contracts to have been 
performed by VacTex on its part prior to the date hereof, 
and VacTex has no reason to believe that it will not be able 
to fulfill, when due, all of its obligations under the 
VacTex Contracts which remain to be performed after the date 
hereof;

	(iii)	VacTex is not in breach of or default under any 
VacTex Contract, and no event has occurred which with the 
passage of time or giving of notice or both would constitute 
such a default, result in a loss of rights or result in the 
creation of any lien, charge or encumbrance, thereunder or 
pursuant thereto;

	(iv)	there is no existing breach or default by any 
other party to any VacTex Contract, and no event has 
occurred which with the passage of time or giving of notice 
or both would constitute a default by such other party, 
result in a loss of rights or result in the creation or any 
lien, charge or encumbrance thereunder or pursuant thereto;

	(v)	VacTex is not restricted by any VacTex Contract 
from carrying on its business anywhere in the world; and

	(vi)	VacTex has no written or oral VacTex Contracts to 
sell products or perform services which are expected to be 
performed at, or to result in a loss.  Except that, 
depending on overhead allocations, some of VacTex's 
government contracts and grants may not be operating at a 
profit.

(d)	The continuation, validity and effectiveness of each 
VacTex Contract will not be affected by the Merger.

(e)	True, correct and complete copies of all VacTex 
Contracts have previously been delivered by VacTex to Aquila.

4.20	Bank Accounts and Powers of Attorney.  Schedule 4.20 
sets forth all bank accounts held in the name of VacTex and all 
bank accounts used in connection with the operations of VacTex 
whether or not such accounts are held in the name of VacTex, 
lists the respective signatories therefore and lists the names of 
all persons holding a power of attorney from VacTex and a summary 
statement of the terms thereof.

4.21	Transactions with Management.  Except as set forth on 
Schedule 4.21, no executive officer or director of VacTex has 
(whether directly or indirectly through another entity in which 
such person has a material interest, other than as the holder of 
less than 5% of a class of securities of a publicly traded 
company) any material interest: in (a) any property or assets of 
VacTex (except as a shareholder), (b) any current competitor, 
customer, supplier or agent of VacTex, or (c) any person which is 
currently a party to any material contract or agreement with 
VacTex.

4.22	Suppliers.  Schedule 4.22 sets forth a true, correct 
and complete list of the names and addresses of the ten suppliers 
of VacTex which accounted for the largest dollar volume of 
purchases by VacTex for the fiscal year ended 1997.  None of such 
suppliers has notified VacTex that it intends to discontinue its 
relationship with VacTex.

4.23 Proprietary Information Agreements.  Each employee and 
each consultant at the time of hire was required to enter into 
VacTex's standard proprietary information agreement, a copy of 
which has been delivered to Aquila.  Except as set forth in 
Schedule 4.23, to the best knowledge of VacTex after due inquiry, 
each employee and each consultant has entered into such 
agreement, and each such employee or consultant of VacTex who is 
or was involved in scientific research or product development has 
entered into such agreement.  

4.24	Disclosure.  No representation or warranty of VacTex in 
this Agreement or any certificate, schedule, document or other 
instrument furnished or to be furnished to Aquila pursuant hereto 
or in connection herewith contains, as of the date of such 
representation, warranty or instrument, or will contain any 
untrue statement of a material fact or, at the date thereof, 
omits or will omit to state a material fact necessary to make any 
statement herein or therein, in light of the circumstances under 
which such statement is or will be made, not misleading.

                        ARTICLE V

             REPRESENTATIONS AND WARRANTIES OF
              AQUILA BIOPHARMACEUTICALS, INC.

Aquila represents, warrants and covenants to VacTex as of 
the Effective Time and as of the date hereof as set forth below.  
The information disclosed on any Schedule shall be deemed to 
relate solely to the section of this Article V to which such 
Schedule relates and shall not be deemed made for other sections 
to which such disclosures may apply unless (i) it is readily 
apparent that such information is clearly applicable to another 
section of this Article V or (ii) such disclosure is cross-
referenced in the Schedule(s) relating to such other section(s), 
and, in each such case, only to the extent that the applicable 
information or risk is described.


5.01	Corporate Organization.  Aquila (i) is a corporation 
duly organized, validly existing and in good standing under the 
laws of the State of Delaware, (ii) has all requisite power and 
authority, corporate and otherwise, to own, operate and lease the 
properties and assets it now owns, operates and leases and to 
carry on its business as now being conducted and (iii) is 
qualified or licensed to do business and in good standing in 
every jurisdiction in which the ownership, operation or lease of 
property by it or the conduct of its business requires such 
qualification or licensing, except for such failures, if any, to 
be so qualified and in good standing, which when taken together 
with all other such failures, would not in the aggregate have a 
Material Adverse Effect on Aquila.  Aquila has previously 
delivered to VacTex complete and correct copies of its Restated 
Certificate of Incorporation ("Aquila Charter") and By-Laws 
("Aquila By-Laws") as presently in effect, and Aquila is not in 
default in the performance, observation or fulfillment of either 
of its Certificate of Incorporation or By-Laws.

5.02	Authorization.  Aquila has full corporate power and 
authority to execute and deliver this Agreement and to consummate 
the transactions contemplated hereby.  The Board of Directors of 
Aquila has duly approved the execution and delivery of this 
Agreement and the consummation of the transactions contemplated 
hereby and no other corporate proceedings on the part of Aquila 
are necessary to authorize this Agreement or to consummate the 
transactions contemplated hereby.  This Agreement has been duly 
and validly executed and delivered by Aquila and, subject to the 
foregoing, this Agreement constitutes (assuming due 
authorization, execution and delivery of this Agreement by VacTex 
and Sub), the valid and binding agreement of Aquila, enforceable 
against Aquila in accordance with its terms.  The shares of 
Aquila Common Stock and the Aquila Debentures to be issued in the 
Merger have been duly authorized by all necessary action of the 
Board of Directors of Aquila and when issued in the Merger 
pursuant to the terms hereof, will not have any preemptive rights 
of subscription or purchase in respect thereof, except for those 
provided by the terms of the Aquila Debentures.

5.03	Capitalization.  (a) The authorized capital stock of 
Aquila consists of 35,500,000 shares of Aquila Common Stock of 
which 5,828,671 shares are issued and outstanding and 5,000,000 
shares of preferred stock, par value $.01 per share, of which no 
shares are issued and outstanding.  As of December 31, 1997, (i) 
831,655 shares of Aquila Common Stock were reserved for issuance 
pursuant to outstanding options granted under stock option plans; 
and (ii) subscriptions were outstanding to purchase 3,900 shares 
of Aquila Common Stock under Aquila's employee stock purchase 
plan.  All shares of Aquila Common Stock outstanding as of the 
date hereof are duly authorized, validly issued, fully paid and 
nonassessable and were not issued in violation of, or subject to, 
any preemptive rights.

(b)	Except as set forth above and on Schedule 5.03, there 
are (i) no shares of capital stock or other voting securities of 
Aquila authorized or outstanding and (ii) no subscriptions, 
options, conversion or exchange rights, warrants, repurchase or 
redemption agreements, or other agreements, claims or commitments 
of any nature whatsoever obligating Aquila to issue, transfer, 
deliver or sell, or cause to be issued, transferred, delivered, 
sold, repurchased or redeemed, additional shares of its capital 
stock or obligating Aquila to grant, extend or enter into any 
such agreement or commitment.  To the knowledge of Aquila, there 
are no voting trusts or other agreements or understandings with 
respect to the voting of the capital stock of Aquila.  Aquila 
does not own beneficially any shares of capital stock of VacTex.

5.04	Non-Contravention; Consents and Approvals.  Except for 
(a) the filing of the Certificate of Merger and other appropriate 
merger documents, if any, as required by the laws of the State of 
Delaware, the execution and delivery of this Agreement by Aquila 
and the consummation of the transactions contemplated hereby, 
will not (i) violate any provision of the Restated Certificate of 
Incorporation or By-Laws of Aquila; (ii) violate any statute, 
ordinance, rule, regulation, order or decree of any court or of 
any public, governmental or regulatory body, agency or authority 
applicable to Aquila or by which any of its properties or assets 
may be bound; (iii) require any filing with or permit, consent or 
approval of, or the giving of any notice to, any public, 
governmental or regulatory body, agency or authority; or (iv) 
result in a violation of, or constitute (with or without due 
notice or lapse of time or both) a default (or give rise to any 
right of termination, cancellation or acceleration) under, any of 
the terms, conditions or provisions of any note, bond, mortgage, 
indenture,	license, franchise, permit, agreement or other 
instrument or obligation to which Aquila is a party, or by which 
Aquila or any of its properties or assets may be bound, excluding 
from the foregoing clauses (ii), (iii) and (iv) violations, 
breaches and defaults which, and filings, notices, permits, 
consents and approvals the absence of which, in the aggregate 
would not have a Material Adverse Effect on Aquila or the ability 
of Aquila to consummate the transactions contemplated hereby.

5.05	SEC Reports.  Aquila has heretofore delivered to VacTex 
its (i) Annual Report on Form 10-K for the years ended 
December 31, 1995, December 31, 1996 and December 31, 1997 as 
filed with the Securities and Exchange Commission ("SEC"), and 
(ii) all other reports or registration statements filed by Aquila 
with the SEC since December 31, 1997.  As of their respective 
dates, such reports and statements complied in all material 
respects with applicable SEC requirements (except for the failure 
of such reports and registration statements to include selected 
financial data for 1992 and 1993) and did not contain any untrue 
statement of a material fact or omit to state a material fact 
required to be stated therein or necessary to make the statements 
therein, in light of the circumstances under which they were 
made, not misleading.

5.06	Financial Statements.  Aquila has previously delivered 
to VacTex (i) the audited financial statements of Aquila as of 
December 31, 1995, December 31, 1996 and December 31, 1997 
including the notes thereto, in each case examined by and 
accompanied by the report of Coopers & Lybrand, L.L.P., 
independent certified public accountants, (hereinafter 
collectively referred to as the "Aquila Audited Financial 
Statements").  The Aquila Audited Financial Statements have been 
prepared from, and are in accordance with, the books and records 
of Aquila and present fairly the financial position of Aquila as 
of the dates and for the periods indicated, in each case in 
conformity with generally accepted accounting principles, 
consistently applied during such periods, and have been certified 
without qualification by Aquila's independent public accountants.  
The Aquila Audited Financial Statements contain and reflect 
adequate reserves with respect to the contracts and commitments 
for the sale of goods or provision of services which are 
consistent with previous reserves taken for all reasonably 
anticipated material losses and costs and expenses and the 
amounts shown as accrued for current and deferred income and 
other taxes in the Aquila Audited Financial Statements are 
sufficient for the payment of all accrued and unpaid federal, 
state and local income taxes, interest, penalties, assessments or 
deficiencies applicable to Aquila, whether disputed or not, for 
the applicable period then ended and periods prior thereto.

5.07	Absence of Undisclosed Liabilities.  Except as and to 
the extent reflected in the balance sheet dated as of December 
31, 1997 included in the Aquila Audited Financial Statements (the 
"Aquila Balance Sheet") or in the notes to the Aquila Audited 
Financial Statements for the fiscal year then ended, Aquila had 
at that date no liabilities or obligations of any nature (whether 
accrued, absolute, contingent or otherwise, and whether due or to 
become due) which are material to Aquila except for those 
incurred in the ordinary course of business and consistent with 
past practice.

5.08	Absence of Certain Changes.  Except as set forth on 
Schedule 5.08, since December 31, 1997, Aquila has not: (i) taken 
any action which would cause Aquila to violate its covenants set 
forth in Section 7.01 (ii) suffered any Material Adverse Effect 
or (iii) entered into any material transaction or conducted its 
business or operations, other than in the ordinary course of 
business consistent with past practice.

5.09	Legal Proceedings; Etc.  Except as set forth on 
Schedule 5.09, there are no suits, actions, claims, proceedings 
or, to the best of Aquila's knowledge after due inquiry, 
investigations or congressional inquiries pending, or, to the 
best knowledge of the officers of Aquila, threatened against, 
relating to or involving Aquila (or any of its officers or 
directors in connection with the business or affairs of Aquila) 
or any properties or rights of Aquila, before any court, 
arbitrator or administrative or governmental body, United States 
or foreign, which if adversely determined would have a Material 
Adverse Effect on Aquila.  There are no such suits, actions, 
claims, proceedings or investigations pending, or, to the best 
knowledge of the officers of Aquila, threatened challenging the 
validity or propriety of the transactions contemplated by this 
Agreement.  Aquila is not subject to any judgment, decree, 
injunction, rule or order of any court or, to the best knowledge 
of the officers of Aquila, any governmental restriction which is 
reasonably likely to have a Material Adverse Effect on Aquila, or 
which materially adversely affects the ability of Aquila to 
acquire any property or conduct business in any area.

5.10	Compliance with Applicable Law.  Except for such 
violations and defaults which in the aggregate would not have a 
Material Adverse Effect on Aquila, (i) Aquila currently holds and 
is in compliance with the terms of all licenses, permits and 
authorizations necessary for the lawful conduct of its business, 
and (ii) Aquila has complied with, and is not in violation of, or 
in default in any respect under, the applicable statutes, 
ordinances, rules, regulations, orders or decrees of all federal, 
state, local and foreign governmental bodies, agencies and 
authorities having, asserting or claiming jurisdiction over it or 
over any part of its operations or assets.

5.11	No Default.  To the best knowledge of Aquila after due 
inquiry, (a) Aquila is not in default or violation under any 
agreement relating to indebtedness for borrowed money to which it 
is a party, which default or violation, after notice or the 
passage of time, or both, would permit the acceleration of 
indebtedness for borrowed money in excess of $50,000 in the 
aggregate and (b) Aquila is not in default or violation under any 
contract, lease or other instrument or agreement to which it is a 
party, (c) Aquila is not in default or violation under any decree 
of any court or any foreign, federal, state, municipal or other 
governmental or regulatory department, agency or authority 
(including, without limitation, applicable laws, rules and 
regulations relating to environmental protection, anti-trust, 
labor and employment, improper payments and civil rights) which 
default or violation would have a Material Adverse Effect on 
Aquila.

5.12	Brokers and Finders.  Neither Aquila nor any of its 
officers, directors or employees has employed any broker or 
finder or incurred any liability for any brokerage fees, 
commissions, finder's fees or similar fees or expenses, and no 
broker or finder has acted directly or indirectly for Aquila in 
connection with this Agreement or the transactions contemplated 
hereby.  Except as set forth on Schedule 5.12, no investment 
banking, financial advisor's or similar fees have been incurred 
or are or will be payable by Aquila in connection with this 
Agreement or the transactions contemplated hereby.

	5.13	Certain Tax Matters. Aquila has timely filed all 
federal, state, county, local and foreign income and other tax 
returns, reports and declarations which are required by 
applicable law to be filed on or before the Effective Time, other 
than returns the failure to file which, in the aggregate, would 
not have a Material Adverse Effect on Aquila.  Aquila has paid or 
will pay before the Effective Time, or where payment is not 
required to be made, has made or will make adequate provisions 
for the payment of, all material taxes, including but not limited 
to income, withholding, unemployment, social security, sales and 
use, and personal property taxes, interest and penalties due and 
payable, in respect of any taxable period ending on or before the 
Effective Time.  For purposes of the preceding sentence, the 
Effective Time shall be treated as the last day of a taxable 
period whether or not the Effective Time is in fact the last day 
of such taxable period.  To the best knowledge of Aquila after 
due inquiry, it will not have any material liability with respect 
to any taxes, in excess of the amount so paid or the reserves for 
taxes so established on the books of Aquila.  Aquila is not 
delinquent in the payment of any taxes required to be paid by it.  
Aquila has not filed a consent to the application of Section 
341(f) of the Code.

5.14	Disclosure.  No representation or warranty of Aquila in 
this Agreement or any certificate, schedule, document or other 
instrument furnished or to be furnished to VacTex pursuant hereto 
or in connection herewith contains, as of the date of such 
representation, warranty or instrument, or will contain any 
untrue statement of a material fact or, at the date thereof, 
omits or will omit to state a material fact necessary to make any 
statement herein or therein, in light of the circumstances under 
which such statement is or will be made, not misleading.


                         ARTICLE VI
              REPRESENTATIONS AND WARRANTIES OF 
                   AQUILA ACQUISITION, INC.

Sub represents, warrants and covenants to VacTex as of the 
Effective Time and as of the date hereof as set forth below:

6.01	Corporate Organization.  Sub (i) is a corporation duly 
organized, validly existing and in good standing under the laws 
of the State of Delaware, (ii) has all requisite power and 
authority, corporate and otherwise, to own, operate and lease the 
properties and assets it now owns, operates and leases and to 
carry on its business as now being conducted and (iii) is 
qualified or licensed to do business and in good standing in 
every jurisdiction in which the ownership, operation or lease of 
property by it or the conduct of its business requires such 
qualification or licensing, except for such failures, if any, to 
be so qualified and in good standing, which when taken together 
with all other such failures, would not in the aggregate have a 
Material Adverse Effect on Sub.  Sub has previously delivered to 
VacTex complete and correct copies of its Certificate of 
Incorporation and By-Laws as presently in effect, and Sub is not 
in default in the performance, observation or fulfillment of 
either of its Certificate of Incorporation or By-Laws.

6.02	Authorization.  Sub has full corporate power and 
authority to execute and deliver this Agreement and to consummate 
the transactions contemplated hereby.  The Board of Directors of 
Sub has duly approved the execution and delivery of this 
Agreement and the consummation of the transactions contemplated 
hereby, and no other corporate proceedings on the part of Sub are 
necessary to authorize this Agreement or to consummate the 
transactions contemplated hereby.  This Agreement has been duly 
and validly executed and delivered by Sub and, subject to the 
foregoing, this Agreement constitutes (assuming due 
authorization, execution and delivery of this Agreement by VacTex 
and Aquila), the valid and binding agreement of Sub, enforceable 
against Sub in accordance with its terms.  The shares of Sub 
Common Stock to be issued in the Merger have been duly authorized 
by all necessary action of the Board of Directors of Sub; and 
when issued in the Merger pursuant to the terms hereof, will not 
have any preemptive rights of subscription or purchase in respect 
thereof.

                           ARTICLE VII

                            COVENANTS


7.01	Conduct of Business.  During the period commencing on 
the date hereof and continuing until the Effective Time, except 
as expressly contemplated by this Agreement or to the extent that 
either Aquila or VacTex, as the case may be, shall otherwise 
consent in writing, which consent may not be unreasonably 
withheld:

(a)	Aquila and VacTex Covenants.  Each of Aquila and VacTex 
agrees that it:

	(i)	will use all reasonable efforts to preserve intact 
or improve its present business organization, properties and 
relationships with customers, consultants, suppliers and 
others having business dealings with it, all to the end that 
its goodwill and ongoing business shall not be materially 
impaired at the Effective Time.

	(ii)	will not declare any dividends on or make other 
distributions in respect of its capital stock or amend the 
VacTex Charter or VacTex By-Laws or the Aquila Charter or 
Aquila By-Laws.

	(iii)	will not issue, authorize or propose the issuance 
of, or purchase or propose the purchase of, any shares of 
its capital stock or securities convertible into, or rights, 
warrants or options to acquire, any such shares or other 
convertible securities except: (A) the issuance by Aquila of 
(x) options pursuant to employee benefit plans consistent 
with prior practices and (y) Aquila Common Stock pursuant to 
outstanding options, and (B) the issuance by VacTex of 
VacTex Common Stock pursuant to outstanding options. 

	(iv)	will not take, agree to take, or knowingly permit 
to be taken any action or do or knowingly permit to be done 
anything in the conduct of the business of VacTex or the 
business of Aquila which would be contrary to or in breach 
of any of the terms or provisions of this Agreement, or 
which would cause any of the representations of Aquila or 
VacTex contained herein to be or become untrue in any 
material respect.

(b)	VacTex Covenants.  VacTex agrees that it:

	(i)	will carry on its business in, and only in, the 
usual, regular and ordinary course in substantially the same 
manner as heretofore conducted;

	(ii)	will not acquire or agree to acquire by merging or 
consolidating with or into, purchasing substantially all of 
the assets or stock of or otherwise, any business or any 
corporation, partnership, association or other business or 
organization or division thereof;

	(iii)	will use its best efforts to retain the services 
of such officers and employees as may be requested by 
Aquila;

	(iv)	will not change the compensation of any of its 
officers, directors, employees or consultants;

	(v)	will not adopt, enter into or amend in any 
material respect any collective bargaining, employee 
pension, profit-sharing, retirement, insurance, incentive 
compensation, severance, vacation or other plan, agreement, 
trust, fund or arrangement for the benefit of employees;

	(vi)	will not enter into, modify or amend any license, 
technology development or technology transfer agreement with 
any other person or entity;

	(vii)	will not: (A) incur any long-term indebtedness for 
borrowed money or issue any debt securities or assume, 
guarantee or endorse the obligations of any other person; 
(B) make any loans, advances or capital contributions to, or 
investments in, any other person except for accounts 
receivable created in the ordinary course of business; (C) 
pledge or otherwise encumber shares of VacTex Common Stock 
or shares of VacTex Preferred Stock; and (D) mortgage or 
pledge any of its material assets, tangible or intangible, 
or create or suffer to exist any material lien thereupon;

	(viii)	will not acquire, sell, lease or dispose of any 
assets outside the ordinary course of business or any assets 
which in the aggregate are material to VacTex;

	(ix)	will not change any of the accounting principles 
or practices used by it;

	(x)	will not pay, discharge or satisfy any claims, 
liabilities or obligations (absolute, accrued, asserted or 
unasserted, contingent or otherwise), other than the 
payment, discharge or satisfaction in the ordinary course of 
business consistent with past practice or in accordance with 
their terms, of liabilities reflected or reserved against 
in, or contemplated by, the VacTex Financial Statements (or 
the notes thereto) incurred in the ordinary course of 
business consistent with past practice, provided that in no 
event shall VacTex repay any long-term indebtedness except 
to the extent required by the terms thereof; or

	(xi)	will not directly or indirectly, including, 
without limitation through its shareholders, officers, 
directors, representatives, employees, agents, bankers, 
attorneys or accountants, solicit, initiate or encourage 
(including by way of furnishing information) any inquiries 
or proposals by, or, except to the extent reasonably 
required by fiduciary obligations under applicable law as 
advised by legal counsel, engage in any discussions or 
negotiations with any corporation, partnership, person or 
other entity or group which it is reasonably expected may 
lead to, or which relates to, any proposal for the sale of 
any capital stock or assets of VacTex (other than in the 
ordinary course of business) or the merger, consolidation or 
other combination of VacTex or its business or assets with 
any other person or entity.  VacTex will promptly advise 
Aquila orally and in writing of the receipt and content of 
any such inquiries or proposals.  

(c)	Aquila Covenants.  Aquila agrees that it will promptly 
after the Effective Time increase the size of its Board of 
Directors to create one vacancy for the class of directors whose 
terms expire in 2000 and will elect or cause to be elected Robert 
J. Carpenter to fill such vacancy.

7.02	Access to Properties and Records.  Between the date of 
this Agreement and the Effective Time, each of Aquila and VacTex 
will provide the other and its accountants, counsel and other 
authorized representatives such access, during reasonable 
business hours and under reasonable circumstances, to its 
premises, properties, contracts, commitments, books, records and 
other information (including tax returns filed and those in 
preparation) and those of its subsidiaries and will furnish to 
the other's representatives such financial, technical and 
operating data and other information pertaining to its business 
as is reasonably necessary or appropriate in connection with the 
transactions contemplated hereunder.  Neither party will use any 
such information obtained from the other in its business and each 
will hold such documents and other material in confidence and, in 
the event of the termination of this Agreement, upon request by 
the other, will deliver to the other all documents and other 
material so obtained by it, except that one copy may be 
maintained in legal files for legal reference indefinitely.

7.03	Registration Rights Agreement.  Aquila and VacTex shall 
enter into a Registration Rights Agreement (the "Registration 
Rights Agreement") in substantially the form attached hereto as 
Exhibit E with respect to the registration of shares of Aquila 
Common Stock to be issued in the Merger.

7.04	Shareholder Approval.  VacTex shall call a meeting of 
its shareholders (or shall seek action by written consent of its 
shareholders) to be held or taken as promptly as practicable for 
the purpose of obtaining shareholder approval or adoption of this 
Agreement, the Merger and the transactions contemplated hereby, 
to the extent required by applicable law.  VacTex agrees that its 
Board of Directors will recommend, subject to fiduciary duties, 
that its shareholders approve the transactions referred to in the 
preceding sentence.

7.05	Best Efforts; Etc.  Subject to the terms and conditions 
herein provided, each of the parties hereto agrees to use its 
best effort's to take, or cause to be taken, all action, and to 
do, or cause to be done, all things necessary, proper or 
advisable under applicable laws and regulations to consummate and 
make effective the transaction contemplated by this Agreement, 
including obtaining any consents, authorizations, exemptions and 
approvals, including the Required Consents, (collectively 
"Consents") from and making all filings with, any third party, 
governmental regulatory or public body or authority, and waivers 
of any violations, breaches and defaults that may be caused by 
the consummation of the transactions contemplated hereby, which 
in each case are necessary or, in the judgment of Aquila, 
desirable in connection with the transactions contemplated by 
this Agreement.  In case at any time after the Effective Time, 
any further action is necessary or, in the judgment of Aquila, 
desirable to carry out the purposes of this Agreement, the proper 
officers and directors of the parties shall take, or cause to be 
taken, all such action.

7.06	Material Events.  At all times prior to the Effective 
Time, each party shall promptly notify the other in writing of 
the occurrence of any event which will or may result in the 
failure to satisfy any of the conditions specified in Article 
VIII hereof.

7.07	Public Announcements.  At all times until the Effective 
Time, each party shall promptly advise and cooperate with the 
other prior to issuing, or permitting any of its subsidiaries, 
directors, officers, employees or agents to issue, any press 
release or other information to the press or any third party with 
respect to this Agreement or the transaction contemplated hereby.

7.08	Stockholders' Agreement.  All of the stockholders of 
VacTex shall have executed a certain stockholders agreement 
substantially in the form attached hereto as Exhibit F pursuant 
to which, among other things, each of the stockholders makes 
certain representations to Aquila and appoints a representative 
to act on his or her behalf.


                        ARTICLE VIII

                    CLOSING CONDITIONS


8.01	Conditions to the Obligation of Each Party.  The 
respective obligations of each party to consummate the Merger 
shall be subject to the satisfaction or waiver, at or before the 
Effective Time, of each of the following conditions:

(a)	Approvals.  All required approvals of the shareholders 
of VacTex and all Consents and waivers required to be obtained 
pursuant to Section 7.05 hereof, shall have been obtained; 
provided, however, that if Aquila waives the obtaining of any 
Consent or waiver the absence of which would not have a Material 
Adverse Effect on Aquila, such Consent or waiver shall not be a 
condition to VacTex's obligation to consummate the Merger.  

(b)	Absence of Order.  No restraining order or injunction 
of any court which prevents consummation of the Merger shall be 
in effect.

8.02	Additional Conditions to the Obligation of Aquila and 
Sub.  The obligation of Aquila and Sub to consummate the Merger 
shall also be subject to the satisfaction or waiver by Aquila and 
Sub at or prior to the Effective Time of each of the following 
conditions:

(a)	Representation and Warranties True.  The 
representations and warranties of VacTex contained in this 
Agreement shall be true and correct in all material respects as 
of the date hereof and as of the Closing (as defined in Section 
10.01) as if made at and as of the Closing, except as otherwise 
contemplated by this Agreement, each of the obligations of VacTex 
to be performed by it on or before the Effective Time pursuant to 
the terms hereof, including obtaining the Consents, shall have 
been duly performed in all material respects, and VacTex shall 
have delivered to Aquila a certificate to that effect dated the 
day of Closing and signed by the chief executive officer of 
VacTex.

(b)	Opinions of VacTex's Counsel.  Aquila shall have been 
furnished with (i) an opinion from Palmer & Dodge LLP, counsel to 
VacTex, dated the Closing Date, substantially to the effect set 
forth in Schedule 8.02A and (ii) an opinion from VacTex's patent 
counsel dated the Closing Date substantially to the effect set 
forth in Schedule 8.02B.

(d)	Dissenting Shares.  VacTex Dissenting Shares shall not 
exceed one percent (1%) of the shares of VacTex Common Stock 
issued and outstanding on the Effective Time.

(e)	Certificates.  VacTex shall have furnished Aquila with 
such certificates of its officers and others to evidence 
compliance with the conditions set forth in this Article VIII as 
may be reasonably requested by Aquila.

8.03	Additional Conditions to the Obligation of VacTex.  The 
obligation of VacTex to consummate the Merger shall also be 
subject to the satisfaction or waiver by VacTex at or prior to 
the Effective Time of each of the following conditions:

(a)	Representations and Warranties True.  The 
representations and warranties of Aquila contained in this 
Agreement shall be true and correct in all material respects as 
of the date hereof and as of the Effective Time (as if made at 
and as of the Effective Time, except as otherwise contemplated by 
this Agreement), each of the obligations of Aquila to be 
performed by it on or before the Effective Time pursuant to the 
terms hereof shall have been duly performed and complied with in 
all material respects and Aquila shall have delivered to VacTex a 
certificate to that effect dated the Effective Time and signed by 
the chief executive officer of Aquila.

(b)	Opinion of Aquila's Counsel.  VacTex shall have been 
furnished with an opinion from Bowditch & Dewey, LLP, counsel to 
Aquila, dated the Closing Date, substantially to the effect set 
forth in Schedule 8.03.

(c)	Certificates.  Aquila shall have furnished VacTex with 
such certificates of its officers and others to evidence 
compliance with the conditions set forth in this Article VIII as 
may be reasonably requested by VacTex.


                            ARTICLE IX

                   TERMINATION AND ABANDONMENT


9.01	Termination.  This Agreement may be terminated, and the 
Merger abandoned, at any time prior to the Effective Time:

(a)	by the mutual consent of the Boards of Directors of 
Aquila and VacTex;

(b)	by Aquila or by VacTex at any time after June 30, 1998, 
if, by that date, through no breach of this Agreement on the part 
of the terminating party, the conditions set forth in Article 
VIII hereof shall not have been satisfied or waived;

(c) by Aquila if there shall have been a breach of any 
representation or warranty on the part of VacTex set forth in 
this Agreement or if any representation or warranty of VacTex 
shall have become untrue in either case such that the conditions 
set forth in Section 8.02 would be incapable of being satisfied 
by June 30, 1998 (or as otherwise extended) or there shall have 
been a breach by VacTex of its covenants or agreements hereunder 
having a Material Adverse Effect on VacTex or materially 
adversely affecting (or materially delaying) the consummation of 
the Merger, and VacTex has not cured such breach within five (5) 
business days following notice by Aquila thereof.

(d)	by VacTex if there shall have been a breach of any 
representation or warranty on the part of Aquila set forth in 
this Agreement or if any representation or warranty of Aquila 
shall have become untrue in either case such that the conditions 
set forth in Section 8.03 would be incapable of being satisfied 
by June 30, 1998 (or as otherwise extended) or there shall have 
been a breach by Aquila of its covenants or agreements hereunder 
having a Material Adverse Effect on Aquila or materially 
adversely affecting (or materially delaying) the consummation of 
the Merger, and Aquila has not cured such breach within five (5) 
business days following notice by VacTex thereof.

9.02	Effect of Termination.  In the event of the termination 
of this Agreement pursuant to Section 9.01, this Agreement shall 
become null and void and there shall be no liability hereunder on 
the part of either party to the other except for fraud, willful 
misconduct or bad faith and except as provided in the 
confidentiality provisions of Section 6.02 and in Sections 9.03, 
10.02 and 10.03 hereof, which Sections shall survive any such 
termination and continue in effect thereafter.

9.03	Liability of Aquila Upon Termination.  If this 
Agreement shall be terminated pursuant to Section 901(d) then 
Aquila shall pay VacTex within 5 business days of such 
termination the sum of $800,000.00.


                            ARTICLE X

                       GENERAL PROVISIONS

10.01 Closing.  Consummation of the transactions contemplated 
by this Agreement and delivery of the documents required under 
Article VIII (the "Closing") shall take place at the offices of 
Bowditch & Dewey, 311 Main Street, Worcester, Massachusetts, at a 
time and on a date (the "Effective Time") agreed to by the 
parties which shall be as promptly as practicable after the 
satisfaction or waiver of the conditions set forth in Article 
VIII, but no later than June 30, 1998. 

At the Closing:  (i) there shall be delivered to Aquila and 
VacTex the opinions, certificates and other documents and 
instruments provided to be delivered under Article VIII hereof; 
and (ii)  upon surrender of certificates of VacTex Common Stock 
and VacTex Preferred Stock, Aquila and Sub shall deliver or cause 
to be delivered to the stockholders, or any of their 
representatives surrendering such certificates, certificates 
evidencing the number of shares of Aquila Common Stock and Aquila 
Debentures to be received by each stockholder under Section 3.01 
hereof.

10.02	Expenses.  All costs and expenses incurred in 
connection with this Agreement, and the transactions contemplated 
hereby shall be paid by the party incurring such expenses.

10.03	Non-Survival of Representations, Warranties and 
Agreements.  The representations, warranties, covenants and 
agreements contained herein or in any certificate delivered 
pursuant to the provisions hereof shall not survive the Merger 
and shall terminate at the Effective Time or upon any termination 
of this Agreement except for the provisions of Article IX; the 
confidentiality provisions of Section 7.02 and Section 10.03.

10.04	Headings.  The descriptive headings of the 
Articles and Sections of this Agreement are inserted for 
convenience only and do not constitute a part of this Agreement.

10.05	Notices.  Any notices or other communications 
required or permitted hereunder shall be sufficiently given if 
sent by certified or registered mail, postage prepaid, addressed 
as follows:

(a) If to Aquila or to Sub, to:

Aquila Biopharmaceuticals, Inc.
365 Plantation Street
Biotechnology Research Park
Worcester, MA 01605
Attention: President

	Copy to:

Attorney Jane V. Hawkes
Bowditch & Dewey, LLP
311 Main Street
Worcester, MA. 01608

(b) If to VacTex, to:

VacTex, Inc.
c/o Robert J. Carpenter, Chairman
9 Lowell Road
Wellesley Hills, MA   02181

Copy to:

Attorney Lynnette C. Fallon
Palmer & Dodge LLP
One Beacon Street
Boston, MA   02108

or such other address as shall be furnished in writing by either 
party, and any such notice or communication shall be deemed to 
have been given as of the date so mailed.

10.06	Assignment.  This Agreement and all of the 
provisions hereof shall be binding upon and inure to the benefit 
of the parties hereto and their respective successors and 
permitted assigns, but neither this Agreement nor any of the 
rights, interests, or obligations hereunder, may be assigned 
without the prior written consent of the other parties.

10.07	Complete Agreement.  This Agreement, including the 
schedules and exhibits hereto, and the other writings referred to 
herein or delivered pursuant hereto contain the entire 
understanding of the parties with respect to the Merger and the 
related transactions and supersede all prior arrangements or 
understandings with respect thereto.

10.08	Modifications, Amendments and Waivers.  At any 
time prior to the Effective Time, (i) the boards of directors of 
Aquila and VacTex may, by written agreement, modify, amend or 
supplement any term or provision of this Agreement or extend the 
time for performance of any obligation hereunder and (ii) any 
term or provision of this Agreement may be waived by the party 
which is, or whose shareholders are, entitled to the benefits 
thereof; provided, however, that after this Agreement is approved 
by the shareholders of VacTex, no such amendment or modification 
shall be made which would change the amount or the kind of Aquila 
securities to be received in exchange for the shares of VacTex 
Common Stock and VacTex Preferred Stock as provided in Article 
III, alter or, except as provided herein, change any term of the 
Certificate of Incorporation of the Surviving Corporation or 
adversely affect the rights of such shareholders, without the 
further approval of the shareholders so affected.  Any written 
instrument or agreement referred to in this paragraph shall be 
validly and sufficiently authorized for the purposes of this 
Agreement if signed on behalf of Aquila and VacTex by persons 
authorized to sign this Agreement.

10.09	Counterparts.  This Agreement may be executed in 
two or more counterparts all of which shall be considered one and 
the same agreement and each of which shall be deemed an original.

10.10	Governing Law.  This Agreement shall be governed 
by the laws of The Commonwealth of Massachusetts, regardless of 
the laws that might be applicable under principles of conflicts 
of law, (except for compliance with the GCL with respect to the 
merger of Delaware corporations with respect to which Delaware 
law shall govern) as to all matters, including but not limited to 
matters of validity, construction, effect and performance.

10.11	Accounting Terms.  All accounting terms used 
herein which are not expressly defined in this Agreement shall 
have the respective meanings given to them in accordance with 
generally accepted accounting principles.

10.12	Severability.  If any term, provision, covenant or 
restriction of this Agreement is held by a court of competent 
jurisdiction or other authority to be invalid, void, 
unenforceable or against its regulatory policy, the remainder of 
the terms, provisions, covenants and restrictions of this 
Agreement shall remain in full force and effect and shall in no 
way be affected, impaired or invalidated.

IN WITNESS WHEREOF, Aquila, Sub and VacTex have caused this 
Agreement to be executed by their respective duly authorized 
officers under seal as of the date first written above.


                           AQUILA BIOPHARMACEUTICALS, INC.



                           By:______________________________
                              Name
                              Title 
						       

	
                           AQUILA ACQUISITION, INC.



                           By:______________________________
                              Name
                              Title


                           VACTEX, INC.



                           By:______________________________
                              Name
                              Title





_______________________________________________________________





AGREEMENT AND PLAN OF MERGER
among

AQUILA BIOPHARMACEUTICALS, INC.
AQUILA ACQUISITION, INC.
and 
VACTEX, INC.









Dated as of April ___, 1998
______________________________________________________________

                      TABLE OF CONTENTS
                                                     Page
INDEX OF TERMS                                        iv

ARTICLE I - THE MERGER                                 1
        1.01    The Merger                             1 
        1.02    Effective Time of the Merger           2
ARTICLE II - THE SURVIVING CORPORATION                 2
        2.01    Certificate of Incorporation           2
        2.02    By-Laws                                2
        2.03    Officers and Directors                 2

ARTICLE III - CONVERSION OF SHARES                     2
        3.01    Conversion of Shares                   2
        3.02    Exchange of Certificates               3
        3.03    No Fractional Securities               3
        3.04    Closing of VacTex Transfer Books       3
        3.05    Dissenting Shares                      3  
        3.06 Transfer of Aquila Common Stock and
Aquila Debentures                                      4
	3.07	Rights of Holders of VacTex Common Stock and
                VacTex Preferred Stock                 4

ARTICLE IV - REPRESENTATION AND WARRANTIES OF
VACTEX, INC.                                           4
        4.01    Corporate Organization                 4
        4.02    Authorization                          5
        4.03    Capitalization                         5
	4.04	Non-Contravention; Consents and
                Approvals                              6
        4.05    Equity Ownership                       6
        4.06    Financial Statements                   6
        4.07    Absence of Undisclosed Liabilities     7
        4.08    Absence of Certain Changes             7
        4.09    Legal Proceedings, etc                 7
        4.10    Compliance with Applicable Law         7
        4.11    No Default                             8
        4.12    Brokers and Finders                    8
        4.13    Certain Tax Matters                    8
        4.14    Employee Benefit Plans                 9
        4.15    Employee Matters                       9
        4.16    Intellectual Properties               10
        4.17    Environmental Compliance              11
        4.18    Insurance                             12
        4.19    Contracts and Commitments             12
        4.20    Bank Accounts and Powers of Attorney  14
        4.21    Transactions with Management          15
        4.22    Suppliers                             15
        4.23    Proprietary Information Agreements    15
        4.24    Disclosure                            15

ARTICLE V -    REPRESENTATIONS AND WARRANTIES OF
        AQUILA BIOPHARMACEUTICALS, INC..              15
        5.01    Corporation Organization              16
        5.02    Authorization                         16
        5.03    Capitalization                        16
	5.04	Non-Contravention; Consents and
                Approvals                             17
        5.05    SEC Reports                           17
        5.06    Financial Statements                  17
        5.07    Absence of Undisclosed Liabilities    18
        5.08    Absence of Certain Changes            18
        5.09    Legal Proceedings; Etc.               18
        5.10    Compliance with Applicable Law        18
        5.11    No Default                            18
        5.12    Brokers and Finders                   19
        5.13    Certain Tax Matters                   19
        5.14    Disclosure                            19
	
ARTICLE VI - REPRESENTATIONS AND WARRANTIES OF 
        AQUILA ACQUISITION, INC.                      19
        6.01    Corporate Organization                20
        6.02    Authorization                         20

ARTICLE VII - COVENANTS                               20
        7.01    Conduct of Business                   20
        7.02    Access to Properties and Records      22
        7.03    Registration Rights Agreement         23
        7.04    Shareholder Approval                  23
        7.05    Best Efforts; Etc.                    23
        7.06    Material Events                       23
        7.07    Public Announcements                  23
        7.08    Stockholders' Agreement               23

ARTICLE VIII - CLOSING CONDITIONS                     24
8.01 Conditions to the Obligation of Each Party       24
8.02 Additional Conditions to the Obligation 
        of Aquila and Sub                             24
8.03 Additional Conditions to the Obligation 
        of VacTex                                     25

ARTICLE IX - TERMINATION AND ABANDONMENT              25
        9.01    Termination                           25
        9.02    Effect of Termination                 26
        9.03    Liability of Aquila Upon Termination  26
	
ARTICLE X - GENERAL PROVISIONS                        26
        10.01 Closing                                 26
        10.02 Expenses                                26
	10.03 Non-Survival of Representations, 
                 Warranties and Agreements            26
        10.04 Headings                                27
        10.05 Notices                                 27
        10.06 Assignment                              27
        10.07 Complete Agreement                      28
        10.08 Modifications, Amendments and Waivers   28
        10.09 Counterparts                            28
        10.10 Governing Law                           28
        10.11 Accounting Terms                        28
        10.12 Severability                            28

SIGNATURES                                            29

Exhibit A	Certificate of Incorporation of Surviving 
	Corporation		
Exhibit B	By Laws of Surviving Corporation		
Exhibit C	Officers and Directors of Surviving Corporation		
Exhibit D	Form of Aquila Debenture		
Exhibit E	Registration Rights Agreement		
Exhibit F	Stockholders' Agreement		





INDEX OF TERMS
Affiliate		
Aquila		
Aquila Audited Financial Statements		
Aquila Balance Sheet		
Aquila By-Laws		
Aquila Charter		
Aquila Common Stock		
Aquila Debentures		
Certificate of Merger		
Code		
Consents		
Constituent Corporations		
Closing		
Effective Time		
Environmental Laws		
ERISA		
GCL		
Material Adverse Effect		
Merger		
Registration Rights Agreement		
Required Consents		
SEC		
Section 262		
Sub		
Sub Common Stock		
Surviving Corporation		
VacTex		
VacTex Audited Financial Statements		
VacTex Balance Sheet		
VacTex By-Laws		
VacTex Charter		
VacTex Common Stock		
VacTex Contracts		
VacTex Dissenting Shares		
VacTex Environmental Permits		
VacTex Intellectual Properties		
VacTex Preferred Stock		

- - 30 -







                                EXHIBIT 4.1

THIS DEBENTURE HAS NOT BEEN REGISTERED UNDER THE SECURITIES ACT 
OF 1933, AS AMENDED OR ANY STATE SECURITIES LAWS, AND SUCH 
DEBENTURE MAY NOT BE SOLD OR TRANSFERRED UNLESS SUCH SALE OR 
TRANSFER IS IN ACCORDANCE WITH THE REGISTRATION REQUIREMENTS OF 
THE SECURITIES ACT OF 1933, AS AT THE TIME AMENDED, OR IN 
CONFORMITY WITH THE LIMITATIONS OF RULE 144 OR SIMILAR RULE AS 
THEN IN EFFECT UNDER SUCH ACT, OR UNLESS SOME OTHER EXEMPTION 
FROM THE REGISTRATION REQUIREMENTS OF SUCH ACT IS AVAILABLE WITH 
RESPECT THERETO.


              AQUILA BIOPHARMACEUTICALS, INC.

                 7% SUBORDINATED DEBENTURE

                                                               No. R-



Maturity Date:  April 10, 2003

Principal Amount:	

							
FOR VALUE RECEIVED, Aquila Biopharmaceuticals, Inc., a Delaware 
corporation (herein called the "Company"), promises to pay to 
_______, or its registered assigns (the "Holder"), the Principal 
Amount upon presentation and surrender of this debenture at the 
office of the Company on the Maturity Date, or earlier 
acceleration or redemption, with interest to accrue on the unpaid 
balance of said principal amount from time to time outstanding at 
the rate of Seven Percent (7%) per annum, said interest to be 
payable on the Maturity Date or earlier acceleration or 
redemption.

        1. Description of Debenture.

                1.1     The Debenture.  This debenture is one of a duly 
authorized issue of debentures of the Company, designated as its 
7% Subordinated Debentures (herein called the "Debenture(s)"), 
limited to the aggregate principal amount of One Million Three 
Hundred Thousand Dollars ($1,300,000.).  The Debentures are 
issuable in registered form, without coupons, in denominations of 
One Thousand Dollars ($1,000.) and any amount in excess thereof.

		1.2	Transfer.  This Debenture is issuable only in 
registered form and is transferable, only on the books of the 
Company by the Holder or by its duly authorized attorney.  The 
Company may deem and treat the Holder of this Debenture as the 
absolute owner hereof for all purposes notwithstanding any notice 
to the contrary.  All payments made to such Holder shall, to the 
extent thereof, effectively satisfy and discharge the obligations 
of the Company hereunder.  The Holder will not directly or 
indirectly or voluntarily offer, sell, pledge, transfer or 
otherwise dispose of (or solicit any offers to buy, purchase or 
otherwise acquire or take a pledge of) this Debenture, except in 
compliance with the Securities Act of 1933, as amended and the 
rules and regulations promulgated thereunder.

		1.3	Payment of Principal and Interest.  Interest and 
principal on this Debenture shall be payable by the Company on 
the Maturity Date or earlier on acceleration or redemption as set 
forth herein, by the Company's check mailed to the Holder of the 
Debenture at its address of record on the books of the Company.  
In the event of any transfer of a Debenture pursuant to Section 
1.2, the new Debenture or Debentures shall be dated as of the 
date to which interest shall have been paid on the Debenture or 
Debentures surrendered.

		1.4	Lost or Destroyed Debentures.  Upon receipt of 
evidence satisfactory to the Company that any Debenture has been 
mutilated, destroyed or lost, and upon proof of ownership and 
receipt of indemnity from the holder of the Debenture 
satisfactory in form and substance to the Company, the Company 
shall execute and deliver a new Debenture stated to mature on the 
same date and for the same principal amount as the Debenture so 
mutilated, destroyed or lost, of like tenor with such notations, 
if any, as the Company shall reasonably determine, upon surrender 
and cancellation of, and in exchange and substitution for, such 
mutilated Debenture, or in lieu of and in substitution for the 
Debenture so destroyed or lost.

	2.	Redemption.

		2.1	Optional Redemption.  This Debenture is subject to 
redemption prior to maturity, at the option of the Company, as a 
whole or in part on any date after December 31, 1998, at a 
redemption price equal to 100% of the principal amount to be 
redeemed, plus accrued interest to the redemption date, without 
premium.  If this Debenture is to be redeemed, the Company shall 
give notice to the Holder which notice shall state the date 
effective for redemption and specify the office of the Company at 
which the Debenture will be redeemed.  On the redemption date 
there shall become due and payable the redemption price together 
with interest accrued to the redemption date, and after such date 
interest hereon shall cease to accrue.  The Company shall mail 
the redemption notice no more than 60 days nor less than 30 days 
prior to redemption date to the Holder at its address shown on 
the registration books maintained by the Company.

		2.2	Tender for Redemption.  This Debenture is subject 
to tender to the Company, as a whole only, at the election of the 
Holder for redemption at a redemption price equal to 100% of the 
principal amount hereof, plus accrued interest, to the redemption 
date.  In order to exercise the right to tender, the Holder must 
deliver to the Company at any time after April 10, 1999, a 
written irrevocable notice of tender in the form set forth on 
Exhibit A hereto.  The Company shall redeem the Debenture on the 
business day specified in such election notice provided such date 
is at least 30 calendar days after receipt by the Company of such 
notice.

	3.	Subordination.

		3.1	The Company, for itself, its successors and 
assigns, covenants and agrees, and the Holder, by its acceptance 
of this Debenture, likewise covenants and agrees, that the 
payment of the principal of and interest on this Debenture is 
hereby expressly subordinated, to the extent and in the manner 
hereinafter in this Section 3 set forth, in right of payment, to 
the prior payment in full of all Senior Debt. 

                        The term "Senior Debt" shall mean the principal 
of, premium, if any, interest on, and any other payment due 
pursuant to any of the following, whether outstanding at the date 
hereof or hereafter incurred or created:

			(a)	all indebtedness of the Company for money 
borrowed (including any indebtedness secured by a mortgage or 
other lien which is (i) given to secure all or part of the 
purchase price of property subject thereto, whether given to the 
vendor of such property or to another or (ii) existing on 
property at the time of acquisition thereof);

			(b)	all indebtedness of the Company evidenced by 
notes, debentures, bonds or other securities of the Company;

			(c)	all lease obligations of the Company which 
are capitalized on the books of the Company in accordance with 
generally accepted accounting principles;

			(d)	all indebtedness of others of the kinds 
described in either of the preceding clauses (a) or (b) and all 
lease obligations of others of the kind described in the 
preceding clause (c) assumed by or guaranteed in any manner by 
the Company or in effect guaranteed by the Company through an 
agreement to purchase, contingent or otherwise; and 

			(e)	all renewals, extensions or refundings of 
indebtedness of the kinds described in any of the preceding 
clauses (a), (b) and (d) and all renewals or extensions of lease 
obligations of the kinds described in either of the preceding 
clauses (c) and (d);

unless, in the case of any particular indebtedness, lease, 
renewal, extension or refunding, the instrument or lease creating 
or evidencing the same or the assumption or guarantee of the same 
expressly provides that such indebtedness, lease, renewal, 
extension or refunding is subordinate to any other indebtedness 
of the Company or that such indebtedness, lease, renewal, 
extension or refunding is not superior in right of payment to the 
Debentures.

		3.2	Upon any distribution of assets of the Company 
upon any dissolution, winding up, liquidation or reorganization 
of the Company, whether in bankruptcy, insolvency, reorganization 
or receivership proceedings, or upon any assignment for the 
benefit of creditors or any other marshaling of the assets and 
liabilities of the Company or otherwise:

			(a)	all principal, premium, if any, and interest 
due upon all Senior Debt shall first be paid in full, or payment 
thereof provided for in money or money's worth, before the holder 
of this Debenture shall be entitled to receive any payment upon 
the principal of or interest on indebtedness evidenced by the 
Debenture;

			(b)	any payment or distribution of assets of the 
Company of any kind or character, whether in cash, property or 
securities (other than shares of stock of the Company as 
reorganized or readjusted, or securities of the Company or any 
other corporation provided for by a plan of reorganization or 
readjustment, the payment of which is subordinated to the payment 
of all Senior Debt which may at the time be outstanding on terms 
not less favorable to the holder thereof than those of this 
Section) to which the holder of this Debenture would be entitled 
except for the provisions of this Section 3 shall be paid by the 
liquidating Company or agent or other person making such payment 
or distribution, whether a Company in bankruptcy, a receiver or 
liquidating Company or otherwise, directly to the holders of 
Senior Debt (pro rata to each such holder on the basis of the 
respective amounts of Senior Debt held by each such holder), to 
the extent necessary to pay in full all Senior Debt remaining 
unpaid after giving effect to any prior or concurrent payment or 
distribution, or provision therefor, to the holders of Senior 
Debt on the Senior Debt; and

			(c)	in the event that, notwithstanding the 
foregoing, any payment or distribution of assets of the Company 
of any kind or character, whether in cash, property or securities 
(other than shares of stock of the Company as reorganized or 
readjusted, or securities of the Company or any other corporation 
provided for by a plan of reorganization or readjustment, the 
payment of which is subordinated to the payment of all Senior 
Debt which may at the time be outstanding on terms not less 
favorable to the holders thereof than those of this Section) 
shall be received by the holder of this Debenture before all 
Senior Debt is paid in full, or provisions made for its payment, 
such payment or distribution shall be paid over to holders of 
Senior Debt (pro rata to each such holder on the basis of the 
respective amounts of Senior Debt held by such holder), for 
application to the payment of all Senior Debt remaining unpaid 
until all such Senior Debt shall have been paid in full, or 
provision made for its payment, after giving effect to any prior 
or concurrent payment or distribution to the holders of the 
Senior Debt on the Senior Debt.

		3.3	In the event and during the continuance of any 
default by the Company with respect to the payment of any Senior 
Debt when due (whether at a stated maturity date, upon 
acceleration or otherwise), no payment of principal or interest 
on the Debenture shall be made by the Company without the written 
consent of the holders of Senior Debt.

		3.4	Subject to the payment in full of all Senior Debt, 
the holder of this Debenture shall be subrogated to the rights of 
the holders of the Senior Debt to receive payments or 
distributions of assets of the Company applicable to the Senior 
Debt until the principal of and interest on the Debenture shall 
be paid in full.  No such payments or distributions applicable to 
the Senior Debt shall, as between the Company, its creditors 
other than the holders of the Senior Debt, and the holder of this 
Debenture, be deemed to be a payment by the Company to or on 
account of the Debenture.

		3.5	The provisions of this Section 3 are solely for 
the purposes of defining the rights of the holder of this 
Debenture, on the one hand, relative to the rights of the holders 
of the Senior Debt, on the other hand, and nothing contained in 
this Section 3 or elsewhere in the Debenture is intended to or 
shall (i) impair, as between the Company, its creditors other 
than the holders of the Senior Debt, and the holder of this 
Debenture, the obligation of the Company, which is unconditional 
and absolute, to pay to the holder of this Debenture the 
principal of and interest on the Debenture, as and when the same 
shall become due and payable in accordance with the terms of this 
Debenture, or (ii) affect the rights of the holder of this 
Debenture relative to creditors of the Company other than the 
holders of the Senior Debt, nor shall anything herein prevent the 
holder of this Debenture from exercising all remedies otherwise 
permitted by applicable law upon default under this Debenture, 
subject to the rights, if any, under this Section 3 of the 
holders of the Senior  Debt in respect of assets of the Company 
received upon the exercise of any such remedy.

		3.6	Upon any payment or distribution of assets of the 
Company referred to in this Section 3, the holder of this 
Debenture shall be entitled to rely upon any order or decree made 
by any court of competent jurisdiction in which such dissolution, 
winding up, liquidation or reorganization proceedings are pending 
or upon a certificate of the liquidating Company or agent or 
other person making any distribution to the holder of this 
Debenture on the Debenture for the purpose of ascertaining the 
amount of the Senior Debt, the holders thereof, the amount or 
amounts paid or distributed thereon and all other facts pertinent 
thereto or to this Section 3.

	4.	Default.

		4.1	If the Company shall be in default in the payment 
of the principal of, or interest on, this Debenture; or

		4.2	If the Company shall default in the performance of 
or compliance with any provision of this Debenture, and such 
default shall not have been remedied within fifteen (15) days 
after written notice by the Holder unless and for so long as the 
Company is using due diligence to cure such default up to a 
maximum of 45 days after such written notice from the Holder; or 

		4.3	If the Company shall make an assignment for the 
benefit of creditors, or shall admit in writing its inability to 
pay its debts as they become due, or shall file a voluntary 
petition in bankruptcy, or shall be adjudicated a bankrupt or 
insolvent, or shall file any petition or answer seeking for 
itself any reorganization, arrangement, composition, 
readjustment, dissolution or similar relief under any present or 
future statute, law or regulation, or shall file any answer 
admitting the material allegations of a petition filed against 
the Company in any such proceeding, or shall seek or consent to 
or acquiesce in the appointment of any Company, receiver or 
liquidator of the Company or of all or any substantial part of 
the properties of the Company, or the Company or its directors or 
majority stockholders shall take any action to dissolve or 
liquidate or suspend the business of the Company; or 

		4.4	If, within sixty (60) days after the commencement 
of any proceeding against the Company seeking any reorganization, 
arrangement, composition, readjustment, liquidation, dissolution 
or similar relief under any present or future statute, law or 
regulation, such proceeding shall not have been dismissed, or if, 
within sixty (60) days after the appointment without the consent 
or acquiescence of the Company of any Company, receiver or 
liquidator of the Company or of all or any substantial part of 
the properties of the Company, such appointment shall not have 
been vacated; 

then an Event of Default shall have occurred.  In any such event, 
subject to the limitations set forth in paragraph 5, the Holder 
may at any time at its option by written notice to the Company 
declare the principal of and the accrued interest on the 
Debentures to be immediately due and payable, without 
presentment, demand, protest or notice, all of which are hereby 
waived by the Company. 

	5.	Limit on Right of Action.

		The Holder agrees for the benefit of the holders of the 
Senior Debt that so long as any part of the Senior Debt remains 
outstanding, the Holder will not take any action to accelerate or 
demand the payment of the Debenture if it has received a notice 
that the Senior Debt is in default. 

	6.	Remedies and Notices of Default; Modifications.

		In case any Event of Default shall occur, subject to 
the limitations set forth in paragraph 5, the Holder may proceed 
to protect and enforce its rights under this Debenture by a suit 
in equity, action at law or other appropriate proceeding whether 
for the specific performance of any agreement contained herein or 
for an injunction against a violation of any of the terms or 
provisions hereof or in aid of the exercise of any power granted 
hereby or by law.  In case of any Event of Default, the Company 
will reimburse the Holder for its reasonable costs and expenses 
incurred in connection with the enforcement of its rights under 
this Debenture, including without limitation reasonable fees and 
disbursements of its attorneys.  No course of dealing or delay on 
the part of the Holder in exercising any right shall operate as a 
waiver thereof or otherwise prejudice the rights of the Holder 
and no consent or waiver shall extend beyond the particular case 
and purpose involved.  No remedy conferred hereby shall be 
exclusive of any other remedy referred to herein or therein or 
now or hereafter available at law, in equity, by statute or 
otherwise. 

	7.	Miscellaneous.

		7.1	Parties in Interest.  All covenants, agreements, 
and undertakings in this Debenture by and on behalf of any of the 
parties hereto shall bind and inure to the benefit of the 
respective successors and assigns of the parties hereto whether 
so expressed or not. 

		7.2	Amendments and Waivers.  Changes in or additions 
to this Debenture may be made or compliance with any term, 
covenant, agreement, condition or provision set forth herein may 
be omitted or waived (either generally or in a particular 
instance and either retroactively or prospectively), upon written 
consent of (i) the Company, (ii) the Holder hereof and (iii) the 
holders of Senior Debt, if any. 

		7.3	Governing Law.  This Debenture shall be deemed a 
contract made under the laws of The Commonwealth of Massachusetts 
and its provisions and the rights and obligations of the parties 
hereunder, shall be construed and enforced in accordance with and 
governed by the laws of such Commonwealth.

		7.4	Notices.  All notices, requests, consents and 
demands shall be in writing and shall be mailed, postage prepaid, 
to the Company at 365 Plantation Street, Worcester, Massachusetts 
or to the Holder at its address shown on the registration books 
maintained by the Company or to such other address as may be 
furnished in writing to the Company or the Holder.


	IN WITNESS WHEREOF this Debenture has been executed and 
delivered as a sealed instrument as of April ___, 1998, by the 
duly authorized representatives of the Company.

                                            AQUILA BIOPHARMACEUTICALS, INC. 



                                            By:_______________________________
                                               Its


                         EXHIBIT A

                        TO DEBENTURE

                   DEBENTURE TENDER NOTICE





PRINCIPAL AMOUNT
DEBENTURE NUMBER
                   


The undersigned hereby certifies that it is the registered owner 
of the debenture described above (the "Debenture"), and hereby 
agrees that the delivery of this instrument of transfer to the 
Company constitutes an irrevocable offer to sell the Debenture to 
the Company or its designee on the ________, which shall be a 
business day at least thirty (30) calendar days following receipt 
by the Company of this instrument, at a redemption price equal to 
the unpaid principal balance thereof plus accrued and unpaid 
interest thereon to the __________ (the "Redemption Price").  The 
undersigned acknowledges and agrees that this election notice is 
irrevocable and that the undersigned will have no further rights 
with respect to the Debenture except payment, upon presentation 
and surrender of the Debenture at the principal corporate office 
of the Company, of the Redemption Price by wire or bank transfer 
within the continental United States from the Company to the 
undersigned at its address as shown on the registration books of 
the Company. 

Date:		Signature(s)



______________________________


______________________________


______________________________


______________________________
Street         City         
State         Zip


	IMPORTANT:  The above signature(s) must correspond with the 
name(s) as set forth on the face of the Debenture(s) with respect 
to which this notice is being delivered without any change 
whatsoever.  





EXHIBIT 23.1

CONSENT OF INDEPENDENT ACCOUNTANTS

We consent to the inclusion in this Current Report on Form 8-K of our report,
which includes an explanatory paragraph regarding the circumstances which raise 
substantial doubt about the ability of VacTex, Inc. to continue as a going 
concern, dated March 16, 1998, on our audits of the financial statements of 
VacTex, Inc. (a development stage enterprise) as of December 31, 1997 and 1996,
and for each of the two years in the period ended December 31, 1997, and for the
period from November 1, 1995 (date of inception) to December 31, 1997.


/s/Coopers & Lybrand, L.L.P
Boston, Massachusetts
April 24, 1998



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