ALPHA 1 BIOMEDICALS INC
PRE 14A, 2000-09-29
PHARMACEUTICAL PREPARATIONS
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                                  SCHEDULE 14A

                     INFORMATION REQUIRED IN PROXY STATEMENT

                            SCHEDULE 14A INFORMATION
Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934
                                (Amendment No. )

 Filed by the Registrant /X/

 Filed by a Party other than the Registrant / /

 Check the appropriate box:

/X/ Preliminary Proxy Statement

/ / Confidential,for Use of the Commission Only (as permitted by Rule
    14a-6(e)(2))
/ / Definitive Proxy Statement
/ / Definitive Additional Materials
/ / Soliciting Material Pursuant to ss.240.14a-11(c) or ss.240.14a-12

                            ALPHA 1 BIOMEDICALS, INC.
--------------------------------------------------------------------------------
                (Name of Registrant as Specified In Its Charter)

--------------------------------------------------------------------------------
    (Name of Person(s) Filing Proxy Statement, if other than the Registrant)

Payment of Filing Fee (Check the appropriate box):

/X/ No fee required.

/ / Fee computed on table below per Exchange Act Rules 14a-6(i)(1) and 0-11.

     (1)  Title of each class of securities to which transaction applies:

     (2)  Aggregate number of securities to which transaction applies:

     (3)  Per unit  price  or other  underlying  value of  transaction  computed
          pursuant to Exchange  Act Rule 0-11 (set forth the amount on which the
          filing fee is calculated and state how it was determined)

     (4)  Proposed maximum aggregate value of transaction:

     (5)  Total fee paid:

/ / Fee paid previously with preliminary materials.

/ / Check box if any part of the fee is offset as  provided  by  Exchange  Act
    Rule  0-11(a)(2)  and identify the filing for which the  offsetting fee was
    paid  previously.  Identify the previous filing by  registration  statement
    number, or the Form or Schedule and the date of its filing.

         (1)      Amount Previously Paid:
         (2)      Form, Schedule or Registration Statement No.:
         (3)      Filing Party:
         (4)      Date Filed:

<PAGE>
                              [ALPHA 1 LETTERHEAD]





                                November 1, 2000



Dear Fellow Stockholder:

     You are cordially  invited to attend the Annual Meeting of  Stockholders of
Alpha 1  Biomedicals,  Inc.,  to be held at 10:00 a.m.,  local time,  on Friday,
December 15, 2000,  at the Hyatt  Regency  Bethesda,  located at 7400  Wisconsin
Avenue, Bethesda, Maryland 20814.

     An important  aspect of the annual meeting process is the stockholder  vote
on corporate business items. I urge you to exercise your rights as a stockholder
to vote  and  participate  in this  process.  Stockholders  are  being  asked to
consider and vote upon (i) the election of three directors of the Company;  (ii)
a proposed amendment to the Company's certificate of incorporation to change the
Company's name from "Alpha 1 Biomedicals, Inc." to "RegeneRx Biopharmaceuticals,
Inc."; (iii) a proposed amendment to the Company's  certificate of incorporation
to increase the number of shares of common stock  authorized  for issuance  from
20,000,000 to 100,000,000;  (iv) approval of the Company's 2000 Stock Option and
Incentive Plan; and (v) the  ratification of the appointment of Reznick Fedder &
Silverman, P.C. as the Company's independent auditors.

     I encourage you to attend the meeting in person. Whether or not you plan to
attend,  however,  please read the enclosed proxy statement and vote your shares
as  promptly  as  possible.  This will save the  Company  additional  expense in
soliciting  proxies  and will ensure  that your  shares are  represented  at the
meeting.

     Your Board of Directors and  management are committed to the success of the
Company and the  enhancement of the value of your  investment.  As your Chairman
and  President,  I want to  express  my  appreciation  for your  confidence  and
support.

                                       Very truly yours,




                                       Allan L. Goldstein
                                       Chairman, President and Chief
                                         Executive Officer



<PAGE>



                            ALPHA 1 BIOMEDICALS, INC.
                       3 Bethesda Metro Center, Suite 700
                            Bethesda, Maryland 20814
                                 (301) 961-1992


                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
                          TO BE HELD DECEMBER 15, 2000


     NOTICE IS HEREBY GIVEN that the Annual Meeting of  Stockholders  of Alpha 1
Biomedicals, Inc. will be held as follows:

<TABLE>
<CAPTION>

<S>                                   <C>
TIME................................. 10:00 a.m. local time
DATE................................. Friday, December 15, 2000
PLACE................................ Hyatt Regency Bethesda, 7400 Wisconsin Avenue, Bethesda,
                                      Maryland 20814
ITEMS OF BUSINESS.................... (1)  To elect three directors, each for a term expiring at next year's
                                           annual meeting of stockholders.

                                      (2)  To approve a proposed amendment to the Company's certificate of
                                           incorporation to change the Company's name from "Alpha 1
                                           Biomedicals, Inc." to "RegeneRx Biopharmaceuticals, Inc."

                                      (3)  To approve a proposed amendment to the Company's certificate of
                                           incorporation to increase the number of shares of common stock
                                           authorized for issuance from 20,000,000 to 100,000,000.

                                      (4)  To approve the Company's 2000 Stock Option and Incentive Plan.

                                      (5)  To ratify the appointment of Reznick Fedder & Silverman, P.C. as
                                           the Company's independent auditors for the fiscal year ending
                                           December 31, 2000.

                                      (6)  To transact any other business that may properly come before the
                                           meeting and any adjournment or postponement of the meeting.

RECORD DATE.......................... Holders of record of the Company's common stock at the close of
                                      business on October 23, 2000 will be entitled to vote at the meeting
                                      or any adjournment of the meeting.
ANNUAL REPORT........................ The Company's Annual Report to Stockholders is enclosed.
PROXY VOTING......................... It is important that your shares be represented and voted at the
                                      meeting.  You can vote your shares by returning the enclosed proxy
                                      card in the enclosed envelope.  Regardless of the number of
                                      shares you own, your vote is very important.  Please act today.
</TABLE>

                                       BY ORDER OF THE BOARD OF DIRECTORS



                                       ALLAN L. GOLDSTEIN
                                       Chairman of the Board

Bethesda, Maryland
November 1, 2000


<PAGE>



                            ALPHA 1 BIOMEDICALS, INC.
                       3 Bethesda Metro Center, Suite 700
                            Bethesda, Maryland 20814
                                 (301) 961-1992

                  --------------------------------------------


                                 PROXY STATEMENT

                  --------------------------------------------


                         ANNUAL MEETING OF STOCKHOLDERS
                                DECEMBER 15, 2000


<TABLE>
<CAPTION>
                                TABLE OF CONTENTS

                                                                                          PAGE
<S>                                                                                         <C>
INTRODUCTION.................................................................................1

INFORMATION ABOUT THE ANNUAL MEETING.........................................................1
         What is the purpose of the annual meeting?..........................................1
         Who is entitled to vote?............................................................2
         What if my shares are held in "street name" by a broker?............................2
         How many shares must be present to hold the meeting?................................2
         What if a quorum is not present at the meeting?.....................................2
         How do I vote?......................................................................2
         Can I change my vote after I submit my proxy?.......................................3
         How does the Board of Directors recommend I vote on the proposals?..................3
         What if I do not specify how my shares are to be voted?.............................3
         Will any other business be conducted at the annual meeting?.........................3
         How many votes are required to elect the director nominees?.........................3
         What happens if a nominee is unable to stand for election?..........................4
         How many votes are required to approve the other proposals?.........................4
         How will abstentions be treated?....................................................4
         How will broker non-votes be treated?...............................................4

STOCK OWNERSHIP..............................................................................4
         Stock Ownership of Significant Stockholders, Directors and Executive Officers.......4
         Section 16(a) Beneficial Ownership Reporting Compliance.............................6

PROPOSAL 1 - ELECTION OF DIRECTORS...........................................................6
         Board of Directors' Meetings and Committees.........................................7
         Directors' Compensation.............................................................7
         Summary Compensation Table..........................................................8
         Certain Transactions................................................................9

PROPOSAL 2 - AMENDMENT TO THE CERTIFICATE OF INCORPORATION
         TO CHANGE THE COMPANY'S NAME........................................................10

PROPOSAL 3 - AMENDMENT TO THE CERTIFICATE OF INCORPORATION
         TO INCREASE THE AUTHORIZED SHARES OF COMMON STOCK...................................10

PROPOSAL 4 - APPROVAL OF THE 2000 STOCK OPTION AND INCENTIVE PLAN............................12


                                        i

<PAGE>



PROPOSAL 5 - RATIFICATION OF APPOINTMENT OF AUDITORS........................................15

OTHER MATTERS...............................................................................16

ADDITIONAL INFORMATION......................................................................16
         Proxy Solicitation Costs...........................................................16
         Stockholder Proposals for 2001 Annual Meeting......................................16

</TABLE>




                                       ii

<PAGE>



                            ALPHA 1 BIOMEDICALS, INC.
                       3 Bethesda Metro Center, Suite 700
                            Bethesda, Maryland 20814
                                 (301) 564-4400


                  --------------------------------------------


                                 PROXY STATEMENT

                  --------------------------------------------



                                  INTRODUCTION

     The Board of Directors of Alpha 1  Biomedicals,  Inc.  (the  "Company")  is
using this proxy  statement to solicit proxies from the holders of the Company's
common stock for use at the Company's  upcoming Annual Meeting of  Stockholders.
The annual meeting will be held on December 15, 2000 at 10:00 a.m.,  local time,
at the Hyatt  Regency  Bethesda,  located at 7400  Wisconsin  Avenue,  Bethesda,
Maryland  20814. At the annual  meeting,  stockholders  will be asked to vote on
five  proposals:  (1) the election of three  directors  of the Company,  each to
serve for a term expiring at next year's annual meeting of stockholders; (2) the
approval of a proposed  amendment to the Company's  certificate of incorporation
to change the  Company's  name from  "Alpha 1  Biomedicals,  Inc." to  "RegeneRx
Biopharmaceuticals,  Inc.";  (3) the  approval  of a proposed  amendment  to the
Company's  certificate  of  incorporation  to  increase  the number of shares of
common stock  authorized for issuance from  20,000,000 to  100,000,000;  (4) the
approval of the  Company's  2000 Stock Option and  Incentive  Plan;  and (5) the
ratification  of the  appointment  of Reznick  Fedder &  Silverman,  P.C. as the
Company's  independent  auditors  for the fiscal year ending  December 31, 2000.
These  proposals  are  described in more detail  below.  Stockholders  also will
consider any other  matters that may  properly  come before the annual  meeting,
although the Board of Directors knows of no other business to be presented.

     By submitting your proxy, you authorize the Company's Board of Directors to
represent you and vote your shares at the annual meeting in accordance with your
instructions.  The Board also may vote your shares to adjourn the annual meeting
from time to time and will be authorized to vote your shares at any adjournments
or postponements of the annual meeting.

     The  Company's  Annual  Report to  Stockholders  for the fiscal  year ended
December 31, 1999, which includes the Company's annual financial statements,  is
enclosed.  Although the Annual Report is being mailed to stockholders  with this
proxy  statement,  it  does  not  constitute  a part of the  proxy  solicitation
materials and is not incorporated into this proxy statement by reference.

     This proxy  statement  and the  accompanying  materials are being mailed to
stockholders on or about November 1, 2000.

     YOUR  VOTE IS  IMPORTANT.  WHETHER  OR NOT YOU PLAN TO  ATTEND  THE  ANNUAL
MEETING, PLEASE VOTE PROMPTLY.


                      INFORMATION ABOUT THE ANNUAL MEETING

WHAT IS THE PURPOSE OF THE ANNUAL MEETING?

     At the annual meeting,  stockholders will be asked to vote on the following
proposals:

     Proposal 1.    Election of three directors of the Company,  each for a term
                    expiring at next year's annual meeting of stockholders;

     Proposal 2.    Approval   of  a  proposed   amendment   to  the   Company's
                    certificate  of  incorporation  to change the Company's name
                    from   "Alpha   1    Biomedicals,    Inc."   to    "RegeneRx
                    Biopharmaceuticals, Inc.;"




<PAGE>



     Proposal 3.    Approval   of  a  proposed   amendment   to  the   Company's
                    certificate  of  incorporation  to  increase  the  number of
                    shares  of  common  stock   authorized   for  issuance  from
                    20,000,000 to 100,000,000;

     Proposal 4.    Approval of the  Company's  2000 Stock Option and  Incentive
                    Plan; and

     Proposal 5.    Ratification   of  the   appointment  of  Reznick  Fedder  &
                    Silverman,  P.C. as the Company's  independent  auditors for
                    the fiscal year ending December 31, 2000.



Stockholders  also will act on any other  business that may properly come before
the  annual  meeting.  Members  of our  management  team will be  present at the
meeting to respond to your questions.

WHO IS ENTITLED TO VOTE?

     The record date for the meeting is October 23, 2000.  Only  stockholders of
record at the close of  business  on that date are  entitled to notice of and to
vote at the annual meeting.  The only class of stock entitled to be voted at the
annual meeting is the Company's common stock.  Each outstanding  share of common
stock is entitled to one vote for all matters before the annual meeting.  At the
close of business on the record  date,  there were  19,477,429  shares of common
stock outstanding.

WHAT IF MY SHARES ARE HELD IN "STREET NAME" BY A BROKER?

     If your  shares  are held in  "street  name" by a  broker,  your  broker is
required to vote your shares in accordance with your instructions. If you do not
give  instructions to your broker,  your broker will nevertheless be entitled to
vote  your  shares  with  respect  to  "discretionary"  items,  but  will not be
permitted to vote your shares with respect to "non-discretionary"  items. In the
case of  non-discretionary  items,  your  shares  will  be  treated  as  "broker
non-votes." Proposal 4 is expected to be considered a "non-discretionary"  item.
All other proposals are expected to be considered "discretionary items."

HOW MANY SHARES MUST BE PRESENT TO HOLD THE ANNUAL MEETING?

     A quorum  must be present  at the annual  meeting  for any  business  to be
conducted.  The presence at the annual  meeting,  in person or by proxy,  of the
holders of a majority of the shares of common  stock  outstanding  on the record
date will  constitute a quorum.  Proxies  received but marked as  abstentions or
broker  non-votes  will be included in the  calculation  of the number of shares
considered to be present at the annual meeting.

WHAT IF A QUORUM IS NOT PRESENT AT THE ANNUAL MEETING?

     If a quorum is not present at the scheduled time of the annual meeting, the
stockholders  who are  represented may adjourn the annual meeting until a quorum
is present. The time and place of the adjourned meeting will be announced at the
time the  adjournment  is  taken.  An  adjournment  will  have no  effect on the
business that may be conducted at the annual meeting.

HOW DO I VOTE?

     1.  YOU  MAY  VOTE  BY  PROXY.  If  you  properly  complete  and  sign  the
accompanying proxy card and return it in the enclosed envelope, it will be voted
in accordance with your  instructions.  If your shares are held in "street name"
with a bank,  broker or some other third  party,  you also may be able to submit
your proxy vote by telephone or via the  internet.  Check your proxy card to see
if voting by telephone and/or the internet is available to you.

     2. YOU MAY VOTE IN PERSON AT THE ANNUAL MEETING.  If you plan to attend the
annual  meeting  and wish to vote in  person,  we will  give you a ballot at the
annual  meeting.  Note,  however,  that if your shares are held in "street name"
with a bank,  broker or some other third party,  you will need to obtain a proxy
from the record holder of your shares  indicating  that you were the  beneficial
owner of those shares on October 23, 2000, the record date for voting at

                                        2

<PAGE>



the annual  meeting.  You are  encouraged  to vote by proxy  prior to the annual
meeting even if you plan to attend the annual meeting.

CAN I CHANGE MY VOTE AFTER I SUBMIT MY PROXY?

     Yes,  you may revoke your proxy and change your vote at any time before the
polls close at the annual meeting by:

     o    submitting another proxy with a later date;
     o    giving written notice of the revocation of your proxy to the Company's
          Secretary prior to the annual meeting; or
     o    voting  in  person  at the  annual  meeting.  Your  proxy  will not be
          automatically  revoked by your mere  attendance at the annual meeting;
          you must actually vote at the annual meeting to revoke a prior proxy.

HOW DOES THE BOARD OF DIRECTORS RECOMMEND I VOTE ON THE PROPOSALS?

   Your Board recommends that you vote:

     o    FOR election of the three  nominees  named in this proxy  statement to
          the Board of Directors;
     o    FOR approval of the proposed amendment to the Company's certificate of
          incorporation  to change the Company's name from "Alpha 1 Biomedicals,
          Inc." to "RegeneRx Biopharmaceuticals, Inc.";
     o    FOR approval of the proposed amendment to the Company's certificate of
          incorporation  to  increase  the  number of  shares  of  common  stock
          authorized for issuance from 20,000,000 to 100,000,000;
     o    FOR approval of the Company's  2000 Stock Option and  Incentive  Plan;
          and
     o    FOR  ratification  of the  appointment  of Reznick Fedder & Silverman,
          P.C. as the Company's  independent auditors for the fiscal year ending
          December 31, 2000.

WHAT IF I DO NOT SPECIFY HOW MY SHARES ARE TO BE VOTED?

     If  you  submit  an  executed   proxy  but  do  not   indicate  any  voting
instructions, your shares will be voted:

     o    FOR election of the three  nominees  named in this proxy  statement to
          the Board of Directors; and
     o    FOR each of the other proposals.

WILL ANY OTHER BUSINESS BE CONDUCTED AT THE ANNUAL MEETING?

     The Board of Directors knows of no other business that will be presented at
the annual meeting.  If, however,  any other proposal  properly comes before the
stockholders for a vote at the annual meeting, the Board of Directors, as holder
of your proxy, will vote your shares in accordance with its best judgment.

HOW MANY VOTES ARE REQUIRED TO ELECT THE DIRECTOR NOMINEES?

     The affirmative vote of a plurality of the votes cast at the annual meeting
by the holders of shares present in person or by proxy at the annual meeting and
entitled  to vote is required  to elect the three  nominees  named in this proxy
statement as  directors.  This means that the three  nominees will be elected if
they  receive  more  affirmative  votes  than any other  persons  nominated  for
election.  No persons  have been  nominated  for  election  other than the three
nominees named in this proxy  statement.  If you vote "Withheld" with respect to
the election of one or more nominees, your shares will not be voted with respect
to the person or persons  indicated,  although  such  shares will be counted for
purposes of determining whether there is a quorum.

WHAT HAPPENS IF A NOMINEE IS UNABLE TO STAND FOR ELECTION?

     If a nominee is unable to stand for  election,  the Board of Directors  may
either  reduce the number of  directors to be elected (if the Board first amends
the Company's Bylaws to permit the reduction) or select a substitute nominee.

                                        3

<PAGE>



If a substitute nominee is selected,  the Board of Directors,  as holder of your
proxy, will vote your shares for the substitute nominee unless you have withheld
authority to vote for the nominee replaced.

HOW MANY VOTES ARE REQUIRED TO APPROVE THE OTHER PROPOSALS?

     The proposals to amend the Company's certificate of incorporation to change
the  Company's  name and to  increase  the  number of  shares  of  common  stock
authorized  for  issuance  must each be  approved by the  affirmative  vote of a
majority of the outstanding  shares of common stock.  Approval of the 2000 Stock
Option and Incentive Plan and the  ratification  of the  appointment of auditors
each require the affirmative vote of a majority of the votes cast by the holders
of shares  present at the annual  meeting in person or by proxy and  entitled to
vote on the matter.  Approval  of the 2000 Stock  Option and  Incentive  Plan is
conditioned  upon  approval of the proposal to increase the number of authorized
shares.  Therefore,  if the proposal to increase the number of authorized shares
is not  approved,  then the  proposal  to  approve  the 2000  Stock  Option  and
Incentive  Plan will be deemed not to have been  approved.  This is because  the
remaining number of shares of common stock currently  authorized for issuance is
not sufficient to allow for the grant of options under the 2000 Stock Option and
Incentive Plan.

HOW WILL ABSTENTIONS BE TREATED?

     If you abstain from voting, your shares will still be included for purposes
of determining whether a quorum is present. Because directors will be elected by
a plurality  of the votes cast by the holders of shares  present in person or by
proxy at the annual  meeting,  abstaining  is not offered as a voting option for
Proposal 1. If you abstain from voting on any other  proposal,  your shares will
be included in the number of shares  voting on the proposal  and,  consequently,
your abstention will have the effect of a vote against the proposal.

HOW WILL BROKER NON-VOTES BE TREATED?

     Shares  treated  as  broker  non-votes  on one or  more  proposals  will be
included  for purposes of  calculating  the presence of a quorum but will not be
counted  as votes  cast or treated  as shares  entitled  to vote.  Consequently,
broker  non-votes will have the effect of votes against  Proposals 2 and 3 (name
change  and  authorized  shares  increase)  and no  effect  on any of the  other
proposals.

                                 STOCK OWNERSHIP

STOCK OWNERSHIP OF SIGNIFICANT STOCKHOLDERS, DIRECTORS AND EXECUTIVE OFFICERS

     The following table shows, as of October 23, 2000, the beneficial ownership
of the Company's common stock by:

     o    any persons or entities known by management to  beneficially  own more
          than five percent of the outstanding shares of Company common stock;

     o    each director of the Company; and

     o    all of the executive officers and directors of the Company as a group.


                                        4

<PAGE>



     The persons named in the following  table have sole voting and  dispositive
powers  for all  shares of common  stock  shown as  beneficially  owned by them,
subject to community  property laws where  applicable and except as indicated in
the footnotes to the table.

     Beneficial  ownership is  determined  in  accordance  with the rules of the
Securities  and  Exchange   Commission.   Shares  of  common  stock  subject  to
outstanding  options,  warrants or other rights to acquire held by a person that
are currently  exercisable or exercisable  within 60 days after October 23, 2000
are included in the number of shares beneficially owned by the person and deemed
outstanding   shares  for  purposes  of  calculating  the  person's   percentage
ownership.  These shares are not, however, deemed outstanding for the purpose of
computing the percentage  ownership of any other person. As of October 23, 2000,
there were 19,477,429 shares of Company common stock outstanding.

<TABLE>
<CAPTION>
                                                                                                       Percent of
                                                                               Beneficial             Common Stock
                    Name of Beneficial Owner                                    Ownership             Outstanding
-----------------------------------------------------------------        -----------------------   -------------------
<S>                                                                          <C>                         <C>
Roger H. Samet                                                                  997,050(1)                5.04%
254 East 68th Street, #29B
New York, NY 10021
J. J. Finkelstein                                                             1,875,000(2)                9.63
Richard J. Hindin                                                             1,885,000(2)                9.68
Sidney J. Silver                                                              1,875,000(2)                9.63
Allan L. Goldstein, Chairman, President and Chief                             2,342,491(2)(3)            12.03
  Executive Officer
Michael L. Berman,                                                               89,450(4)                0.46
  Former Chief Executive Officer
Joseph C. McNay, Director                                                       792,000(5)                4.03
Albert Rosenfeld, Director, Secretary and Treasurer                              25,100(6)                0.13
All executive officers and directors as a group (3 persons)                   3,159,591(7)               16.06

----------
<FN>
(1)  As reported by Mr. Samet on Amendment  No. One to a Schedule 13D filed with
     the  SEC  on  February  24,  1999.  Mr.  Samet  reported  sole  voting  and
     dispositive  powers as to all  shares  listed.  Included  among the  shares
     listed are 292,050 shares which Mr. Samet has the right to acquire pursuant
     to Class D warrants  issued to him by the Company.  Mr. Samet's  address is
     254 East 68th Street, #29B, New York, NY 10021.

(2)  The  address  for  Dr.  Goldstein  and  Mr.  Finkelstein  is  c/o  Alpha  1
     Biomedicals,  Inc., 3 Bethesda Metro Center, Suite 700, Bethesda,  Maryland
     20814.The  address for Mr. Silver is c/o Silver,  Freedman & Taff,  L.L.P.,
     1100 New York Avenue,  N.W.,  Washington,  D.C. 20005.  The address for Mr.
     Hindin is 407 Chain Bridge Road, McLean, Virginia 22101.

(3)  Consists of (i) 2,156,079 shares owned directly by Dr. Goldstein over which
     he has sole voting and dispositive  powers;  and (ii) 93,206 shares held by
     Dr.  Goldstein's wife with respect to which Dr. Goldstein shares voting and
     dispositive powers.

(4)  Consists of (i) 68,000  shares  directly  owned by Dr. Berman over which he
     has sole voting and  dispositive  powers;  and (ii) 21,450 shares which Dr.
     Berman  has the  right  to  acquire  pursuant  to the  exercise  of Class D
     warrants.  The address for Dr. Berman is c/o Alpha 1  Biomedicals,  Inc., 3
     Bethesda Metro Center, Suite 700, Bethesda, Maryland 20814.

(5)  Consists of (i) 612,000  shares  owned  directly by Mr. McNay over which he
     has sole voting and dispositive  powers; (ii) 15,000 shares which Mr. McNay
     has the right to acquire  through the  exercise of stock  options  that are
     currently  exercisable;  and (iii)  165,000  shares which Mr. McNay has the
     right to acquire pursuant to the exercise of Class D warrants.  The address
     for Mr. McNay is c/o Alpha 1  Biomedicals,  Inc., 3 Bethesda  Metro Center,
     Suite 700, Bethesda, Maryland 20814.


                                        5

<PAGE>



(6)  Consists of (i) 10,100 shares owned directly by Mr. Rosenfeld over which he
     has sole voting and  dispositive  powers;  and (ii) 15,000 shares which Mr.
     Rosenfeld  has the right to acquire  through the exercise of stock  options
     that are currently exercisable.  The address for Mr. Rosenfeld is c/o Alpha
     1 Biomedicals, Inc., 3 Bethesda Metro Center, Suite 700, Bethesda, Maryland
     20814.

(7)  Consists  of (i)  2,871,385  shares  owned  directly by all  directors  and
     executive  officers of the Company as a group; (ii) 30,000 shares which all
     directors  and  executive  officers  as a group  have the right to  acquire
     through the exercise of stock options that are currently exercisable; (iii)
     93,206  shares  owned by family  members  of all  directors  and  executive
     officers  as a group;  and (iv)  165,000  shares  which all  directors  and
     executive  officers  as a group have the right to acquire  pursuant  to the
     exercise of Class D warrants.  Does not include  shares held by Dr. Berman,
     the Company's former Chief Executive Officer.
</FN>
</TABLE>

SECTION 16(A) BENEFICIAL OWNERSHIP REPORTING COMPLIANCE

     Section 16(a) of the Securities Exchange Act of 1934, as amended,  requires
the Company's  directors and executive  officers,  and persons who own more than
10% of the Company's common stock, to report to the SEC their initial  ownership
of the  Company's  common stock and any  subsequent  changes in that  ownership.
Specific due dates for these  reports have been  established  by the SEC and the
Company is  required to disclose  in this proxy  statement  any late  filings or
failures to file.

     To the  Company's  knowledge,  based  solely on its review of the copies of
such reports furnished to the Company and written  representations that no other
reports  were  required  during the fiscal year ended  December  31,  1999,  all
Section 16(a) filing requirements applicable to the Company's executive officers
and directors during 1999 were met except for the inadvertent  failure to report
on Form 5 one transaction by Dr. Goldstein.

                       PROPOSAL 1 - ELECTION OF DIRECTORS

     The Company's Board of Directors consists of three directors. Directors are
elected annually to serve one-year terms.

     The three individuals listed below each have been nominated for election as
a director at the annual  meeting,  to hold office until the next annual meeting
of stockholders  and until his successor is elected and qualified.  Each nominee
has consented to being named in this proxy  statement and has agreed to serve if
elected.  If a nominee is unable to stand for  election,  the Board of Directors
may either  reduce the number of directors to be elected (if it first amends the
Company's Bylaws to permit the reduction) or select a substitute  nominee.  If a
substitute nominee is selected, the Board of Directors, as holder of your proxy,
will vote your  shares for the  substitute  nominee,  unless  you have  withheld
authority to vote for the nominee replaced.

     The affirmative vote of a plurality of the votes cast at the annual meeting
by the holders of shares  present in person or by proxy at the annual meeting is
required to elect the nominees named below as directors. YOUR BOARD OF DIRECTORS
RECOMMENDS THAT YOU VOTE "FOR" THE ELECTION OF EACH OF THE NOMINEES.

     The following table sets forth, with respect to each nominee,  his name and
age,  the year in which he first  became  a  director  of the  Company,  and his
principal occupation and business experience during the past five years.

<TABLE>
<CAPTION>

         Nominee, Year First                                        Principal Occupation and
     Became Director of Company       Age                              Business Experience
--------------------------------     ------  ------------------------------------------------------------------------
<S>                                   <C>    <C>
Allan Goldstein, 1982                  62    Chairman of the Board of the Company since 1982; Chief Executive
                                             Officer of the Company from 1982 to 1986, and 1999 to present; Chief
                                             Scientific Advisor of the Company from 1982 to present; Professor
                                             and Chairman of Department of Biochemistry and Molecular Biology
                                             at The George Washington University School of Medicine and Health
                                             Sciences from 1978 to present.
Joseph C. McNay, 1987                  66    Chairman and Director of Essex Investment Management Company,
                                             Inc., a registered investment advisor, from 1976 to present; Director of
                                             Softech, Inc. and MPSI System, Inc.

</TABLE>

                                        6

<PAGE>
<TABLE>
<CAPTION>

         Nominee, Year First                                        Principal Occupation and
     Became Director of Company       Age                              Business Experience
--------------------------------     ------  ------------------------------------------------------------------------
<S>                                   <C>    <C>
Albert Rosenfeld, 1982                 79    Secretary - Treasurer of the Company from 1999 to present;
                                             Consultant on Future Programs for March of Dimes Birth Defect
                                             Foundation from 1973 to present; Adjunct Professor, Department of
                                             Human Biological Chemistry and Genetics at University of Texas
                                             Medical Branch, from 1974 to 1998; frequent author and lecturer on
                                             scientific matters.

</TABLE>

BOARD OF DIRECTORS' MEETINGS AND COMMITTEES

     The  Company's  Board of Directors  met once in fiscal 1999.  Each director
attended this meeting.  During fiscal 1999, no director of the Company  attended
fewer than 75% of the  aggregate of the total  number of Board  meetings and the
total  number of meetings  held by the  committees  of the Board of Directors on
which he served.  The Board of  Directors  of the  Company has  standing  Audit,
Compensation and Stock Option committees.

     The Audit Committee seeks to ensure that appropriate  audits of the Company
are conducted.  In carrying out this  responsibility,  the Audit Committee meets
regularly  with  management  and  representatives  of the Company's  independent
auditors and reviews the scope of internal and external audit activities and the
results of the annual audit. The independent  auditors have direct access to the
Audit Committee to discuss the results of their examination, the adequacy of the
internal  accounting  controls and the  integrity of  financial  reporting.  The
members of the Audit  Committee are Directors  McNay and  Rosenfeld..  The Audit
Committee did not meet during fiscal 1999.

     The  Compensation   Committee  is  responsible  for  the  determination  of
compensation  paid  to  executive  officers.  The  members  of the  Compensation
Committee are Directors McNay and Rosenfeld.  The Compensation Committee did not
meet in fiscal 1999.

     The Stock Option Committee is responsible for  administering  the Company's
stock option plans and in this  capacity  approves  stock  option  grants.  Each
director is a member of the Stock Option  Committee.  The Stock Option Committee
did not meet in fiscal 1999.

     The  entire  Board  of  Directors  of the  Company  acts as the  Nominating
Committee  for  selecting  nominees  for election to the Board.  The  Nominating
Committee  generally  meets  once  per  year  to  make  nominations.  While  the
Nominating  Committee will consider  nominees  recommended by stockholders,  the
Nominating  Committee has not actively  solicited such nominations.  Pursuant to
the Company's  bylaws,  nominations for election as directors by stockholders at
an  annual  meeting  must be made in  writing  and  delivered  to the  Company's
Secretary  not less than 14 days nor more than 120 days prior to the date of the
meeting.  If, however,  notice of the meeting is given to stockholders less than
21 days prior to the meeting,  the nominations  must be received by the close of
business on the seventh day following the day on which notice of the meeting was
mailed to stockholders.

DIRECTORS' COMPENSATION

     Prior to the  Company's  suspension  of  operations  in 1998,  non-employee
directors (Directors McNay and Rosenfeld) were each paid an annual fee of $5,000
and a fee of $1,250 for each meeting attended in person, and were reimbursed for
expenses   incurred  in  attending  Board  meetings.   Upon  the  suspension  of
operations,  the Company discontinued paying director fees. It is uncertain when
the Company will  reinstitute  the payment of director  fees.  Each of Directors
McNay and Rosenfeld  are owed  director  fees earned prior to the  suspension of
operations amounting to $13,916. It is uncertain when these amounts will be paid
and whether these amounts will be paid with interest.


                                        7

<PAGE>



SUMMARY COMPENSATION TABLE

     The following  table  summarizes for the years  indicated the  compensation
paid by the Company to each person who served as the Company's  Chief  Executive
Officer during 1999. No other  executive  officer of the Company earned a salary
and bonus for 1999 in excess of $100,000.

<TABLE>
<CAPTION>
                                                                                              Long Term
                                                  Annual Compensation                    Compensation Awards
                                     ---------------------------------------------     -----------------------
                                                                          Other        Restricted
                                                                         Annual          Stock                      All Other
                                     Fiscal                           Compensation       Award        Options        Compen-
     Name and Principal Position      Year      Salary        Bonus      ($)(2)           ($)           (#)          sation
     ---------------------------      ----    ----------      -----   ------------     ----------    ---------      ---------
<S>                                  <C>      <C>             <C>         <C>            <C>        <C>             <C>
Allan L. Goldstein, President and     1999          ---        ---         ---            ---        1,875,000          ---
Chief Executive Officer(1)            1998          ---        ---         ---            ---              ---          ---
                                      1997          ---        ---         ---            ---          455,121          ---
Michael L. Berman                     1999    $  22,816        ---         ---            ---              ---          ---
Former Chief Executive Officer        1998      104,617        ---         ---            ---              ---          ---
                                      1997      149,820        ---         ---            ---          682,682       $2,960

-----------------
<FN>
(1)  Dr. Goldstein was appointed Chief Executive Officer upon the resignation of
     Dr. Berman in July 1999.

(2)  Neither  Dr.  Goldstein  nor  Dr.  Berman  received  personal  benefits  or
     perquisites  which  exceeded the lesser of $50,000 or 10% of his salary and
     bonus.
</FN>
</TABLE>

     The following  table sets forth certain  information  concerning  grants of
stock options to Drs. Goldstein and Berman during fiscal 1999.

<TABLE>
<CAPTION>

===============================================================================================
                                 OPTION GRANTS IN LAST FISCAL YEAR

                                                     Individual Grants
                            -------------------------------------------------------------------
                             Number of          % of Total
                              Shares             Options
                            Underlying          Granted to         Per Share
                              Options          Employees in        Exercise          Expiration
                              Granted          Fiscal Year           Price              Date
-----------------------------------------------------------------------------------------------
<S>                         <C>                   <C>               <C>              <C>
Allan L. Goldstein           1,875,000             100%              $0.04            08/15/09
Michael L. Berman                  ---             ---                 ---              ---
===============================================================================================
</TABLE>

                                        8

<PAGE>



     The  following  table  provides  information  as to the  value of the stock
options held by Drs. Goldstein and Berman as of December 31, 1999 and the values
realized by them upon the exercise of stock options during fiscal 1999.

<TABLE>
<CAPTION>

===================================================================================================================
                              AGGREGATED OPTION EXERCISES IN LAST FISCAL YEAR AND FY-END
                                                    OPTION VALUES
-------------------------------------------------------------------------------------------------------------------
                                                               Number of
                                                              Securities                        Value of
                                                               Underlying                      Unexercised
                                                              Unexercised                     In-the-Money
                                                              Options at                       Options at
                                                              FY-End (#)                       FY-End ($)
                                                     ----------------------------    ------------------------------
                             Shares
         Name               Acquired       Value
                          on Exercise     Realized   Exercisable    Unexercisable    Exercisable      Unexercisable
                              (#)           ($)          (#)             (#)             ($)               ($)
-------------------------------------------------------------------------------------------------------------------
<S>                          <C>           <C>       <C>                <C>           <C>                 <C>
Allan L. Goldstein            ---           $---      1,875,000          ---           $---(1)             $---
Michael L. Berman             ---           ---          ---             ---             ---                ---

===================================================================================================================
<FN>
(1) An option is  in-the-money  if the exercise price of the option is less than
    the market value of the stock underlying the option. None of Dr. Goldstein's
    options were in-the-money as of December 31, 1999.
</FN>
</TABLE>

CERTAIN TRANSACTIONS

     LOAN TO DR. GOLDSTEIN.  In  May 1994,  the  Company  extended a loan in the
amount of $149,000 to Dr. Goldstein for the purpose of enabling Dr. Goldstein to
meet a margin call on a brokerage account collateralized by Company common stock
at a time when the Board of Directors concluded that it would be contrary to the
best interests of the Company for Dr. Goldstein to sell the shares. The loan was
unsecured and had an interest  rate equal to the prime rate,  with all principal
and interest due on the December 31, 1994 maturity  date. The loan was repaid on
January 1, 1995,  in part with the  proceeds of a second  loan to Dr.  Goldstein
from the Company in the amount of $115,617 that was  unsecured.  The second loan
has an  interest  rate  of  11.5%  and  was to be  repaid  in 36  equal  monthly
installments.

     In February  1996, the terms of the second loan were amended to provide for
the  suspension  of  installment  payments  for 12  months,  but  with  interest
continuing  to accrue.  In March 1997 and December  1997,  the terms of the loan
were further  amended to suspend  installment  payments an  additional  nine and
twelve months,  respectively,  with interest  continuing to accrue.  The Company
suspended  operations  in  1998  and  principal  and  interest  payments  by Dr.
Goldstein  ceased during and subsequent to the  suspension of operations.  As of
December 31, 1999, the balance owed by Dr. Goldstein was $69,674.  In July 2000,
the Company agreed to waive all prior and subsequent  interest  during and after
suspension  of the  Company's  operations  and  approved a payment  plan for the
$69,674 owed by Dr. Goldstein to the Company in 36 equal monthly installments of
$1,935.38.  In August 2000, the Company agreed to pay Dr. Goldstein a consulting
fee of  $5,000  per  month,  $3,000  of which is paid in cash and the  remaining
$2,000 of which is retained by the Company and applied  toward  repayment of the
loan.

     CONSULTING  AGREEMENT.  On August 16,  1999,  the Company  entered  into an
agreement with Dr. Goldstein, J.J. Finkelstein,  Richard J. Hindin and Sidney J.
Silver to serve as financial and business  consultants to the Company and manage
the  Company's  affairs on a  short-term  basis.  This  agreement  was  executed
following  suspension of the Company's operating  activities due to insufficient
funds.  The  agreement  calls for the  consultants  to prepare a  business  plan
specifying a proposed business  strategy for the Company and evaluate  financing
and recapitalization proposals. The agreement also calls for the consultants to,
among  other  things:   work  with  the  Company's  creditors  to  eliminate  or
restructure  its debts;  work with  governmental  agencies to ensure  regulatory
compliance and allow continuation of the

                                        9

<PAGE>



Company's business;  recruit necessary management for the Company; and negotiate
with  companies   interested  in  licensing  or  other  business  and  financial
relationships with the Company.

     In  consideration  for  services  provided  to  the  Company,  each  of the
consultants was granted an option to purchase 1,875,000 shares of Company common
stock at an exercise price of $.04 per share.  In February 2000, each consultant
exercised  his option in full.  The Company  accepted  from each  consultant  as
payment of the  $75,000  exercise  price a note  payable  to the  Company in the
amount of $75,000,  accruing  interest at 6.09% per annum and payable  quarterly
for 36 months.  The notes are  secured by the  shares of  Company  common  stock
issued upon exercise of the options.  Mr.  Finkelstein,  who is responsible  for
performing the day-to-day functions of the Company,  also receives a monthly fee
of $8,000.  In addition,  as noted above, Dr. Goldstein is paid a consulting fee
of $5,000 per month.

           PROPOSAL 2 - AMENDMENT TO THE CERTIFICATE OF INCORPORATION
                          TO CHANGE THE COMPANY'S NAME

     The corporate name of the Company is currently "Alpha 1 Biomedicals,  Inc."
This name reflects what had been the Company's  primary  business focus for most
of its history,  namely, the  commercialization  of Thymosin alpha 1, a 28 amino
acid peptide shown to regulate the immune system in animal  models.  The Company
recently  significantly reduced its commercial  development efforts in this area
by selling all rights and  interests  it had in Thymosin  alpha 1 in a series of
transactions.   The   Company's   current   primary   business   focus   is  the
commercialization  of Thymosin beta 4, a 43 amino acid  peptide.  The Company is
concentrating  its efforts on the use of Thymosin  beta 4 for the  treatment  of
non-healing  wounds and similar medical  problems  through more rapid repair and
the  regeneration  of tissue.  To better reflect the Company's  current  primary
business focus, the Board of Directors  recommends to the stockholders for their
approval at the annual  meeting an amendment  to the  Company's  certificate  of
incorporation  to change the Company's name from "Alpha 1 Biomedicals,  Inc." to
"RegeneRx Biopharmaceuticals, Inc."

     If the amendment is adopted, the first section of the Company's certificate
of incorporation would be amended to read as follows:

     "1. NAME. The name of the corporation is RegeneRx Biopharmaceuticals, Inc."

VOTE REQUIRED FOR APPROVAL

     The affirmative vote of the holders of a majority of the outstanding shares
of Company  common stock is required  for approval of the proposed  amendment to
change the Company's name.

         THE BOARD OF DIRECTORS RECOMMENDS A VOTE FOR THIS PROPOSAL.

           PROPOSAL 3 - AMENDMENT TO THE CERTIFICATE OF INCORPORATION
                TO INCREASE THE AUTHORIZED SHARES OF COMMON STOCK

     On August 10, 2000, the Board of Directors approved a proposed amendment to
the Company's  certificate of incorporation to increase the number of authorized
shares  of  common  stock  of  the  Company  from   20,000,000  to  100,000,000.
Stockholders  are being asked to approve this  proposed  amendment at the annual
meeting.

     The  Company's  certificate  of  incorporation   currently  authorizes  the
issuance of an aggregate  of  20,000,000  shares of common  stock and  1,000,000
shares of  preferred  stock.  As of October 23, 2000,  19,477,429  shares of the
common stock were issued and outstanding,  leaving only 522,571shares  available
for  issuance.  This is an  insufficient  number of  shares to cover the  shares
underlying the outstanding  warrants to purchase the Company's  common stock (of
which there are  1,326,666,  with exercise  prices ranging from $.10 to $.13 per
share).  If the  amendment is not  approved,  each of the four  consultants  has
agreed to permit the Company to  repurchase  from them shares at a price of $.04
per share (the exercise price of the options granted to the consultants pursuant
to the consulting  agreement and exercised by them in February  2000),  on a pro
rata  basis,  sufficient  in number to allow for the  exercise  of any  warrants
sought to be  exercised.  In addition,  if the  amendment is not  approved,  the
proposal to approve the Company's 2000 Stock Option and Incentive Plan (Proposal
4) will be deemed not to have been  approved.  No shares of preferred  stock are
outstanding.

                                       10

<PAGE>




     In addition to ensuring  there are a  sufficient  number of shares to cover
the Company's  outstanding  stock options and warrants,  the amendment will give
the Company  greater  flexibility in its financial  affairs by making 75 million
additional  shares of common stock available for issuance by the Company in such
transactions and at such times as the Board of Directors considers  appropriate,
whether in public or  private  offerings,  as stock  splits or  dividends  or in
connection   with  mergers  and   acquisitions   or  otherwise.   The  Company's
stockholders  may  or may  not be  given  the  opportunity  to  vote  on  such a
transaction, depending on the nature of the transaction,  applicable law and the
judgment of the Company's  Board of Directors  regarding  the  submission of the
transaction to a vote of the Company's stockholders.  The Company has no present
plans or agreements for the issuance of the proposed additional shares of common
stock.

     The additional  shares of common stock authorized for issuance  pursuant to
the  proposed  amendment  will have all of the rights and  privileges  which the
presently outstanding shares of common stock possess; the increase in authorized
shares will not affect the terms,  or rights of holders,  of existing  shares of
common stock.  All outstanding  shares would continue to have one vote per share
on all matters to be voted on by the  shareholders,  including  the  election of
directors.  Holders of common stock have no preemptive or conversion  rights and
are not  subject  to  further  calls  or  assessments  by the  Company.  Because
stockholders  do  not  have  preemptive   rights,   the  interests  of  existing
stockholders may (depending on the particular  circumstances in which additional
capital  stock is issued) be diluted by any issuance of the proposed  additional
shares of common stock.

     It is possible that  additional  shares of common stock could be issued for
the  purpose of making an  acquisition  by an unwanted  suitor of a  controlling
interest in the Company more difficult, time-consuming or costly or to otherwise
discourage   an  attempt  to  acquire   control  of  the  Company.   Under  such
circumstances,  the  availability  of authorized and unissued shares may make it
more  difficult  for  stockholders  of the Company to obtain a premium for their
shares.  These  authorized and unissued shares could be used to create voting or
other  impediments  or to frustrate a person or other  entity  seeking to obtain
control of the  Company by means of a merger,  tender  offer,  proxy  contest or
other means. For instance,  shares could be privately placed with purchasers who
might  cooperate with the Company's Board of Directors in opposing an attempt by
a third party to gain  control of the  Company by voting the shares  against the
transaction  with the third party or could be used to dilute the stock ownership
or voting rights of a person or entity seeking to obtain control of the Company.

     Although the Company's  Board of Directors  does not  currently  anticipate
issuing  additional shares of common stock for purposes of preventing a takeover
of the Company,  the Company's Board of Directors reserves its right (consistent
with its fiduciary responsibilities) to issue shares for that purpose.

         If the proposed amendment is adopted,  the first sentence of the fourth
section of the Company's  certificate of incorporation  would be amended to read
as follows:

     "4.  AUTHORIZED  CAPITAL STOCK. The total number of shares of capital stock
which the  Corporation  shall have the  authority  to issue is One  Hundred  One
Million  (101,000,000)  shares  divided  into two  classes of which One  Million
(1,000,000)  shares  of the par value of $.001  per  share  shall be  designated
Preferred Stock and One Hundred Million (100,000,000) shares of the par value of
$.001 per share shall be designated Common Stock."

VOTE REQUIRED FOR APPROVAL

     The affirmative vote of the holders of a majority of the outstanding shares
of Company  common stock is required  for approval of the proposed  amendment to
increase the number of authorized shares of common stock.

     THE BOARD OF DIRECTORS RECOMMENDS A VOTE FOR THIS PROPOSAL.



                                       11

<PAGE>



        PROPOSAL 4 - APPROVAL OF THE 2000 STOCK OPTION AND INCENTIVE PLAN

PURPOSE

     The purpose of the 2000 Stock Option and  Incentive  Plan is to promote the
long-term  interests  of the  Company and its  stockholders  by  attracting  and
retaining  directors,   officers,   employees,   consultants  and  advisors  and
motivating these persons to exert their best efforts on behalf of the Company.

     In furtherance of these  objectives,  the Company's  Board of Directors has
adopted the Stock Option Plan,  subject to approval by the  stockholders  at the
annual  meeting.  If  Proposal  3,  the  proposed  amendment  to  the  Company's
certificate of incorporation to increase the number of authorized shares, is not
approved,  then the proposal to approve the Stock Option Plan will be deemed not
to have been approved.  This is because the remaining number of shares currently
authorized  for issuance is not  sufficient to allow for the exercise of options
granted under the Stock Option Plan.

     A summary of the Stock  Option Plan is set forth  below.  This  summary is,
however,  qualified by and subject to the more complete information set forth in
the Stock Option  Plan,  a copy of which is attached to this proxy  statement as
Appendix A.

ADMINISTRATION OF THE STOCK OPTION PLAN

     The Stock  Option Plan will be  administered  by a committee  comprised  of
either each member of the Board of Directors or two or more members of the Board
of  Directors  appointed  by the  Board of  Directors,  each of whom  must be an
"outside director," as defined in Section 162(m) of the Internal Revenue Code of
1986, as amended, and a "non-employee  director," as defined in Rule 16b-3 under
the Securities Exchange Act of 1934, as amended. The Committee will:

     o    select   persons  to   receive   options   from  among  the   eligible
          participants;

     o    determine  the  number  of  shares   underlying   options  granted  to
          participants;

     o    set the terms,  conditions  and  provisions of the options  consistent
          with the terms of the Stock Option Plan; and

     o    establish rules for the administration of the Stock Option Plan.

The  Committee  has the power to interpret the Stock Option Plan and to make all
other determinations necessary or advisable for its administration.

     In  granting  options  under the Stock  Option  Plan,  the  Committee  will
consider,  among other factors,  the value of the  individual's  services to the
Company, and the added  responsibilities of such individual being in the service
of a public company.

NUMBER OF SHARES THAT MAY BE AWARDED

     Under the Stock  Option  Plan,  the  Committee  may  grant  options  for an
aggregate of 1,000,000 shares of Company common stock.  This amount  represented
approximately  5.13 percent of the shares issued and  outstanding  as of October
23,  2000.  The Stock  Option Plan also  provides  that no person may be granted
options for more than 100,000 shares during any calendar year.

     The  1,000,000  shares of Company  common stock  available  under the Stock
Option Plan are  subject to  adjustment  in the event of certain  changes in the
Company's  capitalization,  such as changes  resulting from stock  dividends and
stock splits.  As described in greater detail below,  the total number of shares
reserved  for issuance  under the Stock Option Plan may increase  over time as a
result of the "reload" feature contained in the Stock Option Plan.

                                       12

<PAGE>



Shares  underlying  options that expire or are  terminated  unexercised  will be
available again for issuance under the Stock Option Plan.

     The Stock  Option Plan  provides  for the use of  authorized  but  unissued
shares or treasury shares. Treasury shares are previously issued and outstanding
shares of Company  common stock which are no longer  outstanding  as a result of
having been repurchased or otherwise reacquired by the Company.

RELOAD FEATURE

     The number of shares  available for options under the Stock Option Plan may
be increased, from time to time and without stockholder approval, as a result of
the plan's "reload" provision.  Under the "reload" provision,  additional shares
may be added to the remaining  shares  available  under the Stock Option Plan as
follows:

     (i)  shares  repurchased  by the Company,  in the open market or otherwise,
          with an aggregate price no greater than the cash proceeds  received by
          the  Company  from the  exercise  of options  granted  under the Stock
          Option Plan; and

     (ii) any shares of  Company  common  stock  surrendered  to the  Company in
          payment of the exercise price of stock options granted under the Stock
          Option Plan.

ELIGIBILITY TO RECEIVE AWARDS

     The  Committee  may  grant  options  to  directors,   officers,  employees,
consultants  and advisors of the Company.  The Committee  will select persons to
receive  options  among the eligible  participants  and  determine the number of
shares underlying the options to be granted.

EXERCISE PRICE OF OPTIONS

     Under the terms of the Stock Option Plan,  the exercise  price of an option
may not be less than the fair market  value of the common  stock on the date the
option is granted.  In the case of an "incentive stock option" (explained below)
granted to a person who is the beneficial  owner of more than ten percent of the
outstanding  shares of Company common stock, the exercise price must not be less
than 110% of the fair market value of the common stock on the date of grant.

EXERCISABILITY OF OPTIONS AND OTHER TERMS AND CONDITIONS

     Options  under the Stock  Option Plan may not be  exercised  later than ten
years after the grant date.  Subject to the limitations  imposed by the Internal
Revenue Code,  certain of the options granted under the Stock Option Plan may be
designated  "incentive  stock  options."  Incentive  stock  options  may  not be
exercised  later than ten years after the grant date,  except that an  incentive
stock option  granted to a person who is the  beneficial  owner of more than ten
percent of the  outstanding  shares of Company common stock may not be exercised
later than five years after the grant date.  Options which are not designated as
and do not  otherwise  qualify as  incentive  stock  options are  referred to as
"non-qualified stock options."

     The Committee  will determine the time or times at which a stock option may
be  exercised  in whole or in part and the method or  methods by which,  and the
form or forms in which, payment of the exercise price of the stock option may be
made. Unless otherwise  determined by the Committee and set forth in the written
award agreement  evidencing the grant of the stock option,  upon  termination of
service  of the  participant  for any reason  other  than for  cause,  all stock
options then currently  exercisable by the participant  will remain  exercisable
for the lesser of (i) three months  following  such  termination  of service and
(ii) the period of time until the  expiration  of the stock option by its terms.
Upon  termination  of  service  for  cause,  all stock  options  not  previously
exercised will immediately be forfeited.


                                       13

<PAGE>



EFFECT OF CHANGE IN CONTROL

     Under the Stock  Option  Plan,  in the event of a change in  control of the
Company,  unless the  Committee  has provided  otherwise in the award  agreement
evidencing the grant of the option,  all  outstanding  options granted under the
Stock  Option Plan which are not fully  vested  will vest in full.  A "change in
control" of the Company will be deemed to occur if any of the  following  events
arise:  (1) any person or group  becomes the  beneficial  owner of 50 percent or
more of the outstanding shares of Company common stock; (2) as a result of or in
connection  with any cash  tender  offer,  merger,  sale of assets or  contested
election,  there is a change in a majority of the Company's  Board of Directors;
or (3) the Company's  stockholders  approve an agreement  providing either for a
transaction in which the Company will no longer be an independent publicly-owned
company or for a sale of all or nearly all of the Company's assets.

TRANSFERABILITY OF OPTIONS

     An  incentive  stock  option  awarded  under the Stock  Option  Plan may be
transferred  only upon the death of the holder to whom it has been  granted,  by
will or the laws of inheritance. A non-qualified stock option may be transferred
during the lifetime of the person to whom it was granted pursuant to a qualified
domestic  relations  order or by gift to any  member of the  person's  immediate
family or to a trust for the  benefit  of any member of the  person's  immediate
family.

EFFECT OF MERGER ON OPTION OR RIGHT

     Upon a merger or other  business  combination of the Company in which it is
not the surviving entity (or in which it is the surviving entity,  but where the
shares of Company  common stock are  converted  into other  securities,  cash or
other  property),  the  Stock  Option  Plan  provides  that  each  holder  of an
outstanding  option will have the right,  after  consummation of the transaction
and during the  remaining  term of the option,  to receive upon  exercise of the
option an amount  equal to the  excess of the fair  market  value on the date of
exercise of the securities or other consideration  receivable in the transaction
in respect of a share of common  stock over the  exercise  price of the  option,
multiplied  by the number of shares of common  stock  with  respect to which the
option is exercised.  This amount may be payable fully in cash,  fully in one or
more of the kind or kinds of property payable in the  transaction,  or partly in
cash and  partly  in one or more of such kind or kinds of  property,  all in the
discretion of the Committee.

AMENDMENT AND TERMINATION

     The Stock Option Plan will remain in effect for a term of ten years,  after
which no options may be granted.  The Board of Directors  may at any time amend,
suspend or  terminate  the Stock  Option Plan or any portion of the Stock Option
Plan,  except  to  the  extent  stockholder  approval  is  necessary  under  any
applicable federal or state law or regulation or the rules of any stock exchange
or automated  quotation  system on which the Company's  common stock may then be
listed or quoted. No amendment,  suspension or termination of the plan, however,
may impair the rights of any  participant,  without his or her  consent,  in any
option grant made pursuant to the Stock Option Plan.

FEDERAL INCOME TAX CONSEQUENCES

     Under current federal tax law, a  non-qualified  stock option granted under
the Stock  Option Plan will not result in any taxable  income to the optionee at
the time of grant or any tax deduction to the Company.  Upon the exercise of the
non-qualified  stock  option,  the  excess  of the  market  value of the  shares
acquired over their cost (i.e.,  the exercise  price) is taxable to the optionee
as ordinary  income and is generally  deductible by the Company.  The optionee's
tax  basis  for the  shares  is the  market  value of the  shares at the time of
exercise.  Upon the sale of the shares,  any appreciation in value of the shares
from the time of exercise  will be recognized by the optionee as a capital gain;
this  capital  gain will be a  short-term  capital  gain (and taxed at  ordinary
income  rates) if the shares are sold within one year after the  exercise  and a
long-term capital gain if the shares are sold more than one year after exercise.

     Neither the grant nor the  exercise of an incentive  stock  option  granted
under the Stock  Option  Plan will result in any  federal  tax  consequences  to
either the optionee or the Company.  Except as described  below, at the time the
optionee sells shares  acquired  pursuant to the exercise of an incentive  stock
option,  the excess of the sale price over the exercise  price will qualify as a
long-term  capital gain. If the optionee disposes of the shares within two years
of the date of grant or within one year of the date of exercise, an amount equal
to the difference between the fair market value of

                                       14

<PAGE>



the  shares on the date of  exercise  and the  exercise  price  will be taxed as
ordinary  income and the Company  will be  entitled  to a deduction  in the same
amount.  The excess, if any, of the sale price over the fair market value at the
time of exercise  will qualify as long-term  capital gain if the shares are sold
more than one year after the option is exercised.  If the optionee  exercises an
incentive  stock option more than three months after his or her  termination  of
employment,  he or she  generally  is deemed to have  exercised a  non-qualified
stock option.  The time frame within an incentive  stock option may be exercised
following  termination of employment is extended to one year if the  termination
results from the death or disability of the optionee.

VOTE REQUIRED FOR APPROVAL

     The  affirmative  vote of a majority  of the votes  cast by the  holders of
shares  present at the annual meeting in person or by proxy and entitled to vote
is required to approve the Stock Option Plan.

     THE BOARD OF DIRECTORS RECOMMENDS A VOTE "FOR" THIS PROPOSAL.

              PROPOSAL 5 - RATIFICATION OF APPOINTMENT OF AUDITORS

     PricewaterhouseCoopers  LLP,  the  independent  accounting  firm  that  was
previously engaged as the principal  accountant to audit the Company's financial
statements,  was dismissed effective April 25, 2000. The audit reports issued by
PricewaterhouseCoopers  LLP for the  years  ended  December  31,  1996  and 1997
contained  an  explanatory  paragraph  expressing  substantial  doubt  about the
ability of the Company to continue as a going concern. The change in accountants
was approved by the Company's Board of Directors.  During the Company's two most
recent fiscal years and the  subsequent  interim  period through April 25, 2000,
there were no disagreements between the Company and  PricewaterhouseCoopers  LLP
on any  matter  of  accounting  principles  or  practices,  financial  statement
disclosure,  or  auditing  scope or  procedure  which,  if not  resolved  to the
satisfaction    of    PricewaterhouseCoopers     LLP,    would    have    caused
PricewaterhouseCoopers  LLP to  make  reference  to the  subject  matter  of the
disagreement or disagreements  in its report.  Subsequent to March 6, 1998 there
were no reports issued by PricewaterhouseCoopers LLP.

     Effective  April 25, 2000, the Company  engaged  Reznick Fedder & Silverman
P.C. as its principal  accountant to audit the Company's  financial  statements.
During the Company's two most recent fiscal years and subsequent interim periods
prior to the  engagement of Reznick  Fedder & Silverman,  P.C.,  the Company did
not, nor did anyone on the Company's behalf, consult Reznick Fedder & Silverman,
P.C.  regarding  either  (A)  the  application  of  accounting  principles  to a
specified completed or proposed  transaction,  or the type of audit opinion that
might be rendered on the  Company's  financial  statements as to which a written
report or oral advice was provided to the Company  that was an important  factor
considered by the Company in reaching a decision as to an  accounting,  auditing
or  financial  reporting  issue,  or (B) any  matter  that was the  subject of a
disagreement  between  the Company  and  PricewaterhouseCoopers  LLP or an event
described in paragraph 304(a)(1)(v) of the SEC's Regulation S-K.

     The Board of Directors has appointed  Reznick  Fedder & Silverman,  P.C. as
principal  accountant for the fiscal year ending  December 31, 2000,  subject to
the  ratification of the  appointment by  stockholders at the annual meeting.  A
representative  of Reznick  Fedder &  Silverman,  P.C. is expected to attend the
annual meeting to respond to appropriate  questions and will have an opportunity
to make a statement if he or she so desires.

VOTE REQUIRED FOR APPROVAL

     The  affirmative  vote of a majority  of the votes  cast by the  holders of
shares  present in person or by proxy at the annual meeting and entitled to vote
is required to approve the  ratification  of the appointment of Reznick Fedder &
Silverman, P.C. as the Company's independent auditors for the fiscal year ending
December 31, 2000.

     THE BOARD OF DIRECTORS RECOMMENDS A VOTE "FOR" THIS PROPOSAL.



                                       15

<PAGE>


                                  OTHER MATTERS

     The Board of Directors knows of no other business that will be presented at
the annual meeting.  If any other matter properly comes before the  stockholders
for a vote at the  annual  meeting,  the Board of  Directors,  as holder of your
proxy, will vote your shares in accordance with its best judgment.


                             ADDITIONAL INFORMATION

PROXY SOLICITATION COSTS

     The Company  will pay the costs of  soliciting  proxies.  The Company  will
reimburse  brokerage  firms and other  custodians,  nominees and fiduciaries for
reasonable  expenses  incurred  by  them  in  sending  proxy  materials  to  the
beneficial  owners of the Company's common stock. In addition to solicitation by
mail,  directors,  officers  and  employees  of the Company may solicit  proxies
personally  or  by  facsimile,   telegraph  or  telephone,   without  additional
compensation.

STOCKHOLDER PROPOSALS FOR 2001 ANNUAL MEETING

     If you intend to  present a  stockholder  proposal  at next  year's  annual
meeting, your proposal must be received by the Company at its executive offices,
located at 3 Bethesda Metro Center,  Suite 700,  Bethesda,  Maryland  20814,  by
December 26, 2000 to be eligible for inclusion in the Company's  proxy materials
for that meeting. Your proposal will be subject to the requirements of the proxy
rules adopted  under the  Securities  Exchange Act of 1934, as amended,  and the
Company's certificate of incorporation and bylaws and Delaware law.

     If you submit a proposal for  presentation  at next year's  annual  meeting
that is not  intended for  inclusion in the  Company's  proxy  materials,  or is
intended  for  inclusion  but is  properly  excluded  from the  Company's  proxy
materials,  the  persons  named  in the  form of proxy  sent by the  Company  to
stockholders  will have the  discretion  to vote on your  proposal in accordance
with their best  judgment if your proposal is not received at the main office of
the Company by March 12, 2001.









                                       16

<PAGE>
                            ALPHA 1 BIOMEDICALS, INC.

                      2000 Stock Option and Incentive Plan


     1. PLAN  PURPOSE.  The  purpose  of the Plan is to  promote  the  long-term
interests  of the  Corporation  and its  stockholders  by  providing a means for
attracting  and  retaining  directors,  officers,  employees,   Consultants  and
Advisors of the  Corporation  and its Affiliates and to motivate such persons to
exert their best efforts on behalf of the Corporation and its Affiliates.

     2. DEFINITIONS. The following definitions are applicable to the Plan:

     "Advisor" -- means an advisor  retained by the  Corporation or an Affiliate
who:  (i) is a natural  person;  and (ii)  provides  bona fide  services  to the
Corporation or an Affiliate, which services are not in connection with the offer
or sale of securities in a capital-raising  transaction,  and do not directly or
indirectly promote or maintain a market for the Corporation's securities.

     "Affiliate" -- means any "parent  corporation" or "subsidiary  corporation"
of the  Corporation,  as such  terms are  defined  in  Sections  424(e) and (f),
respectively, of the Code.

     "Board" -- means the board of directors of the Corporation.

     "Cause" -- means  Termination of Service by reason of personal  dishonesty,
incompetence,  willful  misconduct,  breach of fiduciary duty involving personal
profit, intentional failure to perform stated duties or gross negligence.

     "Code" -- means the Internal Revenue Code of 1986, as amended.

     "Committee" -- means the Committee referred to in Section 3 hereof.

     "Consultant" -- means a consultant retained by the Corporation or a
Affiliate who: (i) is a natural person;  and (ii) provides bona fide services to
the  Corporation or an Affiliate,  which services are not in connection with the
offer  or  sale  of  securities  in a  capital-raising  transaction,  and do not
directly  or  indirectly  promote or  maintain  a market  for the  Corporation's
securities.

     "Corporation" -- means Alpha 1 Biomedicals,  Inc., a Delaware  corporation,
and any successor thereto.

     "Disability" -- has the meaning  assigned to such term in Section  22(e)(3)
of the Code, or any successor provision.

     "Incentive  Stock Option" -- means an option to purchase  Shares granted by
the  Committee  which is intended to qualify as an incentive  stock option under
Section 422(b) of the Code.  Unless otherwise set forth in the Option Agreement,
any Option  which does not qualify as an  Incentive  Stock Option for any reason
shall be deemed ab initio to be a Non-Qualified Stock Option.


<PAGE>



     "Market  Value"  --  means,  on the date in  question  (or,  if the date in
question is not a trading  day, on the last  trading day  preceding  the date in
question), the per share closing price of the Shares on the principal securities
exchange on which the Shares are listed (if the Shares are so listed), or on the
Nasdaq Stock Market (if the Shares are listed on the Nasdaq Stock  Market),  or,
if not listed on a securities  exchange or the Nasdaq Stock Market,  the average
of the per share closing bid and ask prices of the Shares as reported on the OTC
Bulletin  Board,  or, if such bid and ask  prices  are not  reported  on the OTC
Bulletin  Board,  as reported by any  nationally  recognized  quotation  service
selected by the Committee,  or, if no such price  information  is reported,  the
fair market value on such date of a Share as the Committee shall determine.

     "Non-Qualified  Stock Option" -- means an option to purchase Shares granted
by the Committee which does not qualify,  for any reason,  as an Incentive Stock
Option.

     "Option"  -- means an  Incentive  Stock  Option  or a  Non-Qualified  Stock
Option.

     "Option Agreement" -- means the agreement evidencing the grant of an Option
under the Plan.

     "Participant"  -- means any  director,  officer,  employee,  Consultant  or
Advisor of the Corporation or any Affiliate who is selected to receive an Option
pursuant to Section 5.

     "Plan" -- means  this  Alpha 1  Biomedicals,  Inc.  2000  Stock  Option and
Incentive Plan.

     "Shares" -- means the shares of common stock of the Corporation.

     "Termination  of Service" -- means  cessation  of service,  for any reason,
whether voluntary or involuntary,  so that the affected individual is not either
(i) an employee of the Corporation or any Affiliate for purposes of an Incentive
Stock Option, or (ii) a director,  officer,  employee,  Consultant or Advisor of
the Corporation or any Affiliate for purposes of a Non-Qualified Stock Option.

     3. ADMINISTRATION. The Plan shall be administered by a Committee consisting
of either (i) each member of the Board, or (ii) two or more members of the Board
appointed  by the Board,  each of whom (A) shall be an  "outside  director,"  as
defined  under  Section  162(m)  of  the  Code  and  the  Treasury   regulations
thereunder,  and (B) shall be a  "non-employee  director," as defined under Rule
16b-3 under the Securities  Exchange Act of 1934, as amended,  or any similar or
successor provision.  Except as limited by the express provisions of the Plan or
by resolutions  adopted by the Board, the Committee shall have sole and complete
authority and  discretion to (i) select  Participants  and grant  Options;  (ii)
determine the number of Shares to be subject to types of Options  generally,  as
well as to individual  Options granted under the Plan; (iii) determine the terms
and  conditions  upon  which  Options  shall be  granted  under the  Plan;  (iv)
prescribe the forms and terms of Option  Agreements;  (v) establish from time to
time regulations for the administration of the Plan; and (vi) interpret the Plan
and make all determinations deemed necessary or advisable for the administration
of the Plan.


                                        2

<PAGE>



     A majority of the Committee  shall  constitute a quorum,  and the acts of a
majority of the members present at any meeting at which a quorum is present,  or
acts approved in writing by a majority of the Committee without a meeting, shall
be acts of the Committee.

     4. SHARES SUBJECT TO PLAN.

     (a) Subject to adjustment by the operation of Section 6, the maximum number
of  Shares  with  respect  to which  Options  may be  granted  under the Plan is
1,000,000,  plus (i) the number of Shares  repurchased by the Corporation in the
open  market or  otherwise  with an  aggregate  price no  greater  than the cash
proceeds  received by the Corporation from the exercise of Options granted under
the Plan; plus (ii) any Shares  surrendered to the Corporation in payment of the
exercise  price of Options  granted  under the Plan.  The Shares with respect to
which  Options  may be  granted  under  the Plan may be  either  authorized  and
unissued  Shares or  previously  issued Shares  reacquired  and held as treasury
Shares.  An Option which terminates shall not be considered to have been granted
under the Plan,  and new Options may be granted  under the Plan with  respect to
the number of Shares as to which such termination has occurred.

     (b) During any calendar year, no Participant  may be granted  Options under
the Plan with  respect to more than 100,000  Shares,  subject to  adjustment  as
provided in Section 6.

     5.  OPTIONS.  The  Committee  is  hereby  authorized  to grant  Options  to
Participants  with the following  terms and conditions and with such  additional
terms and  conditions not  inconsistent  with the provisions of the Plan and the
requirements of applicable law as the Committee shall determine:

     (i) EXERCISE  PRICE.  The  exercise  price per Share for an Option shall be
determined by the Committee;  provided,  however, that such exercise price shall
not be less  than  100% of the  Market  Value of a Share on the date of grant of
such Option;  provided,  further,  that in the case of an Incentive Stock Option
granted to an individual who, at the time of grant,  is the beneficial  owner of
stock possessing more than ten percent of the total combined voting power of all
classes of stock of the  Corporation  or any Affiliate (a "Ten Percent  Owner"),
such  exercise  price shall not be less than 110% of the Market Value of a Share
on the date of grant of such Option.

     (ii) OPTION TERM.  The term of each Option shall be fixed by the Committee,
but  shall be no  greater  than ten years in the case of a  Non-Qualified  Stock
Option,  ten  years  in the  case of an  Incentive  Stock  Option  granted  to a
Participant  who is not a Ten  Percent  Owner,  and five  years in the case of a
Incentive Stock Option granted to a Participant who is a Ten Percent Owner.

     (iii) NUMBER OF SHARES AND TIME AND METHOD OF EXERCISE. The Committee shall
determine the number of Shares  underlying  each Option and the time or times at
which an Option may be  exercised  in whole or in part and the method or methods
by which, and the form or forms (including, without limitation, cash, Shares, or
any combination  thereof,  having a fair market value on the exercise date equal
to the relevant  exercise  price) in which,  payment of the exercise  price with
respect thereto may be made or deemed to have been made.

                                        3

<PAGE>



     (iv) INCENTIVE STOCK OPTIONS. Incentive Stock Options may be granted by the
Committee only to employees of the Corporation or its  Affiliates.  No Incentive
Stock Option may be granted more than ten years after the effective  date of the
Plan, as set forth in Section 14. The aggregate  Market Value  (determined as of
the time any  Incentive  Stock  Option is granted) of the Shares with respect to
which  Incentive  Stock  Options  are  exercisable  for  the  first  time  by  a
Participant in any calendar year shall not exceed $100,000.

     (v) TERMINATION OF SERVICE.  Unless  otherwise  determined by the Committee
and set forth in the Option Agreement  evidencing the grant of the Option,  upon
Termination  of Service of a Participant  for any reason other than for Cause or
due to death or  Disability,  each  Option  granted to the  Participant,  to the
extent then  exercisable,  shall remain  exercisable for the lesser of (A) three
months  following  such  Termination of Service and (B) the period of time until
the expiration of the Option by its terms.  Unless  otherwise  determined by the
Committee  and set forth in the  Option  Agreement  evidencing  the grant of the
Option, upon Termination of Service of a Participant due to death or Disability,
each Option granted to the Participant,  to the extent then  exercisable,  shall
remain  exercisable for the lesser of (A) one year following such Termination of
Service  and (B) the  period of time until the  expiration  of the Option by its
terms.  Upon  Termination  of Service of a  Participant  for Cause,  each Option
granted  to the  Participant,  to the  extent not  previously  exercised,  shall
immediately be forfeited.

     6. ADJUSTMENTS UPON CHANGES IN  CAPITALIZATION.  In the event of any change
in the outstanding Shares subsequent to the effective date of the Plan by reason
of  any   reorganization,   recapitalization,   stock  split,   stock  dividend,
combination or exchange of shares,  merger,  consolidation  or any change in the
corporate  structure or Shares of the Corporation,  the maximum aggregate number
and class of shares as to which  Options  may be granted  under the Plan and the
number and class of shares underlying outstanding Options granted under the Plan
(as  well as the  exercise  price  of each  such  outstanding  Option)  shall be
appropriately   adjusted  by  the  Committee,   whose   determination  shall  be
conclusive. Except as otherwise provided herein, any Option which is adjusted as
a result of this Section 6 shall be subject to the same terms and  conditions as
the original Option.

     7. EFFECT OF MERGER ON OPTIONS. In the case of any merger, consolidation or
combination  of  the  Corporation   (other  than  a  merger,   consolidation  or
combination in which the  Corporation is the  continuing  corporation  and which
does not result in the outstanding  Shares being converted into or exchanged for
different securities,  cash or other property, or any combination thereof),  any
Participant to whom an Option has been granted shall have the  additional  right
(subject to the  provisions  of the Plan and any  limitation  applicable to such
Option),  thereafter  and during the term of each such  Option,  to receive upon
exercise  of any such  Option an amount  equal to the excess of the fair  market
value on the date of such exercise of the securities, cash or other property, or
combination thereof,  receivable upon such merger,  consolidation or combination
in respect of a Share over the exercise price of such Option,  multiplied by the
number of Shares with  respect to which such Option  shall have been  exercised.
Such  amount may be payable  fully in cash,  fully in one or more of the kind or
kinds of property  payable in such  merger,  consolidation  or  combination,  or
partly in cash and partly in one or more of such kind or kinds of property,  all
in the discretion of the Committee.

                                        4

<PAGE>



     8.  EFFECT  OF CHANGE  IN  CONTROL.  Each of the  events  specified  in the
following  clauses (i) through (iii) of this Section 8 shall be deemed a "change
in  control":  (i) any third  person,  including a "group" as defined in Section
13(d)(3) of the  Securities  Exchange Act of 1934, as amended,  shall become the
beneficial  owner of shares of the Corporation with respect to which 50% or more
of the total number of votes for the election of the Board may be cast,  (ii) as
a result of, or in  connection  with,  any cash  tender  offer,  merger or other
business  combination,  sale of assets or contested election,  or combination of
the foregoing,  the persons who were directors of the Corporation shall cease to
constitute a majority of the Board, or (iii) the stockholders of the Corporation
shall  approve an  agreement  providing  either for a  transaction  in which the
Corporation will cease to be an independent  publicly-owned corporation or for a
sale  or  other  disposition  of all or  substantially  all  the  assets  of the
Corporation.  If a tender offer or exchange offer for Shares (other than such an
offer by the  Corporation) is commenced,  or if a change in control shall occur,
unless the Committee shall have otherwise provided in the Option Agreement,  all
Options granted and not fully exercisable shall become  exercisable in full upon
the  happening  of such  event;  provided,  however,  that no  Option  which has
previously been exercised or otherwise terminated shall become exercisable.

     9.  ASSIGNMENTS AND TRANSFERS.  No Incentive Stock Option granted under the
Plan  shall  be  transferable  other  than by will or the  laws of  descent  and
distribution.  A  Non-Qualified  Stock Option shall be transferable by will, the
laws of descent and  distribution,  a "domestic  relations order," as defined in
Section  414(p)(1)(B) of the Code, or a gift to any member of the  Participant's
immediate  family or to a trust for the benefit of one or more of such immediate
family members.  During the lifetime of an Option recipient,  an Option shall be
exercisable  only by the  Option  recipient  unless it has been  transferred  as
permitted hereby, in which case it shall be exercisable only by such transferee.
For the purpose of this Section 9, a Participant's "immediate family" shall mean
the Participant's spouse, children and grandchildren.

     10.  CERTAIN  RIGHTS  UNDER THE PLAN.  No person  shall  have a right to be
selected as a Participant nor, having been so selected,  to be selected again as
a Participant, and no director, officer, employee,  Consultant, Advisor or other
person  shall have any claim or right to be granted an Option  under the Plan or
under any other  incentive or similar plan of the  Corporation or any Affiliate.
Neither the Plan nor any action taken hereunder shall be construed as giving any
employee,  Consultant or Advisor any right to be retained in the employ of or as
a Consultant or Advisor to the Corporation or any Affiliate.

     11. DELIVERY AND  REGISTRATION OF STOCK.  The  Corporation's  obligation to
deliver Shares with respect to an Option shall, if the Committee so requests, be
conditioned upon the receipt of a representation as to the investment  intention
of the Participant to whom such Shares are to be delivered,  in such form as the
Committee  shall  determine  to be  necessary  or  advisable  to comply with the
provisions  of the  Securities  Act of 1933, as amended,  or any other  federal,
state  or  local   securities   legislation.   It  may  be  provided   that  any
representation  requirement shall become  inoperative upon a registration of the
Shares or other action  eliminating the necessity of such  representation  under
such Securities Act or other securities  legislation.  The Corporation shall not
be required to deliver any Shares  under the Plan prior to (i) the  admission of
such Shares to listing on any stock  exchange on which Shares may then be listed
and (ii) the  completion of such  registration  or other  qualification  of such
Shares  under any state or federal law,  rule or  regulation,  as the  Committee
shall determine to be necessary or advisable.


                                        5

<PAGE>


     12.  WITHHOLDING  TAX.  Where a Participant  or other person is entitled to
receive Shares  pursuant to the exercise of an Option  pursuant to the Plan, the
Corporation shall have the right to require the Participant or such other person
to pay the Corporation the amount of any taxes which the Corporation is required
to withhold with respect to such Shares, or, in lieu thereof, to retain, or sell
without notice, a number of such Shares  sufficient to cover the amount required
to be withheld.  All withholding  decisions pursuant to this Section 12 shall be
at the sole discretion of the Committee or the Corporation.

     13. AMENDMENT OR TERMINATION.

     (a) The Board may amend, alter, suspend, discontinue, or terminate the Plan
without the consent of shareholders or Participants, except that any such action
will be subject to the approval of the  Corporation's  shareholders if, when and
to the extent such shareholder approval is necessary or required for purposes of
any  applicable  federal  or state law or  regulation  or the rules of any stock
exchange or automated quotation system on which the Shares may then be listed or
quoted, or if the Board, in its discretion,  determines to seek such shareholder
approval.

     (b) The Committee may waive any conditions of or rights of the  Corporation
or modify or amend the terms of any outstanding  Option.  The Committee may not,
however, amend, alter, suspend,  discontinue or terminate any outstanding Option
without the consent of the  Participant or holder  thereof,  except as otherwise
provided herein.

     14.  EFFECTIVE DATE AND TERM OF PLAN. The Plan shall become  effective upon
the later of its  adoption by the Board or its approval by the  shareholders  of
the Corporation.  It shall continue in effect for a term of ten years thereafter
unless sooner terminated under Section 13 hereof.


                                        6


<PAGE>

                                 REVOCABLE PROXY

                            ALPHA 1 BIOMEDICALS, INC.
                         ANNUAL MEETING OF STOCKHOLDERS

                                December 15, 2000

     The  undersigned  hereby  appoints  the  Board  of  Directors  of  Alpha  1
Biomedicals,  Inc.  (the  "Company"),  and its  survivor,  with  full  power  of
substitution,  to act as attorneys and proxies for the  undersigned  to vote all
shares of common stock of the Company which the  undersigned is entitled to vote
at the Annual Meeting of  Stockholders  (the  "Meeting"),  to be held on Friday,
December  15,  2000 at the Hyatt  Regency  Bethesda,  located at 7400  Wisconsin
Avenue,  Bethesda,  Maryland,  at 10:00  a.m.,  local  time,  and at any and all
adjournments and postponements thereof, as follows:

I.   The election of the following directors
     for one-year terms:

                                                   FOR      WITHHELD

     ALLAN L. GOLDSTEIN                            / /        / /

     JOSEPH C. MCNAY                               / /        / /

     ALBERT ROSENFELD                              / /        / /


                                                   FOR      AGAINST     ABSTAIN

II.  The approval of a proposed amendment          / /        / /        / /
     to the Company's certificate of
     incorporation to change the Company's
     name from "Alpha 1 Biomedicals, Inc."
     to "RegeneRx Biopharmaceuticals, Inc."

                                                  FOR      AGAINST     ABSTAIN

III. The approval of a proposed amendment          / /        / /        / /
     to the  Company's certificate of
     incorporation to increase the number of
     shares of common stock authorized for
     issuance from 20,000,000 to 100,000,000.

                                                  FOR      AGAINST     ABSTAIN

IV.  Conditioned upon approval of Proposal         / /        / /        / /
     III, the approval of the Company's
     2000 Stock Option and Incentive Plan.

                                                  FOR      AGAINST     ABSTAIN

V.   The ratification of the appointment of        / /        / /        / /
     Reznick Fedder & Silverman, P.C.
     as independent auditors for the Company
     for the fiscal year ending December 31,
     2000.

In their  discretion,  the proxies are  authorized to vote on any other business
that may properly  come before the Meeting or any  adjournment  or  postponement
thereof.

                 The Board of Directors recommends a vote "FOR"
                    the election of the nominees named herein
                 and "FOR" each of the proposals listed above.


<PAGE>


--------------------------------------------------------------------------------
 THIS PROXY WILL BE VOTED AS DIRECTED,  BUT IF NO INSTRUCTIONS  ARE SPECIFIED,
 THIS PROXY WILL BE VOTED FOR THE  ELECTION OF THE  NOMINEES  NAMED HEREIN AND
 FOR EACH OF THE PROPOSALS LISTED ABOVE. IF ANY OTHER BUSINESS IS PRESENTED AT
 THE  MEETING,  THIS PROXY WILL BE VOTED AS DIRECTED BY THE BOARD OF DIRECTORS
 IN ITS BEST JUDGMENT. AT THE PRESENT TIME, THE BOARD OF DIRECTORS KNOWS OF NO
 OTHER BUSINESS TO BE PRESENTED AT THE MEETING.
--------------------------------------------------------------------------------

           THIS PROXY IS SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS

     This  Proxy may be  revoked  at any time  before it is voted by: (i) filing
with the  Secretary of the Company at or before the Meeting a written  notice of
revocation  bearing  a later  date  than  this  Proxy;  (ii)  duly  executing  a
subsequent  proxy relating to the same shares and delivering it to the Secretary
of the  Company at or before the  Meeting;  or (iii)  attending  the Meeting and
voting in person  (although  attendance at the Meeting will not in and of itself
constitute  revocation  of this  Proxy).  If this Proxy is  properly  revoked as
described  above,  then the power of such  attorneys and proxies shall be deemed
terminated and of no further force and effect.

     The  undersigned  acknowledges  receipt  from  the  Company,  prior  to the
execution of this Proxy,  of Notice of the Meeting the Company's Proxy Statement
and the  Company's  Annual  Report to  Stockholders  for the  fiscal  year ended
December 31, 1999.



     Dated:  ________________________




     -----------------------------------    -----------------------------------
     PRINT NAME OF STOCKHOLDER              PRINT NAME OF STOCKHOLDER



     -----------------------------------    -----------------------------------
     SIGNATURE OF STOCKHOLDER               SIGNATURE OF STOCKHOLDER

     Please sign exactly as your name appears  above on this card.  When signing
     as attorney, executor, administrator, trustee or guardian, please give your
     full title. If shares are held jointly, each holder should sign.

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            PLEASE PROMPTLY COMPLETE, DATE, SIGN AND MAIL THIS PROXY IN
                        THE ENCLOSED POSTAGE-PAID ENVELOPE
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