MEDCO RESEARCH INC
8-K, 1999-12-14
PHARMACEUTICAL PREPARATIONS
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                UNITED STATES SECURITIES AND EXCHANGE COMMISSION
                              Washington, DC 20549


                                    FORM 8-K


                                 CURRENT REPORT
                     Pursuant to Section 13 or 15(d) of the
                         Securities Exchange Act of 1934




                Date of Report (Date of earliest event reported):
                                November 30, 1999
                                -----------------



                              MEDCO RESEARCH, INC.
             ------------------------------------------------------
             (Exact name of registrant as specified in its charter)



     Delaware                       0-13948                       95-3318451
     --------                       -------                       ----------
  (State or other            (Commission File No.)              (IRS Employer
  jurisdiction of                                            Identification No.)
  of incorporation)


7001 Weston Parkway, Suite 300 Cary, NC            27513
- ---------------------------------------            -----
(Address of principal executive offices)         (Zip code)


Registrant's telephone number, including area code:(919)653-7001
                                                   -------------
<PAGE>

ITEM 5.  Other Events.

On  November  30,  1999,  Medco  Research,  Inc.  (the  "Company"),  a  Delaware
corporation,  entered  into  an  Agreement  and  Plan  of  Merger  (the  "Merger
Agreement")  with  King   Pharmaceuticals,   Inc.   ("Acquiror"),   a  Tennessee
corporation,   and  Merlin  Acquisition  I  Corp.  ("Merger  Sub"),  a  Delaware
corporation and wholly-owned subsidiary of Acquiror.

Subject to the terms and conditions of the Merger Agreement,  Merger Sub will be
merged with and into the Company  (the  "Merger") at the  effective  time of the
Merger,  and the Company will become a wholly owned  subsidiary of Acquiror.  At
the effective time of the Merger,  each outstanding share of common stock of the
Company  ("Company Common Stock"),  other than shares of Company Common Stock to
be canceled in accordance with the Merger Agreement,  will be converted into the
right to receive a portion  of a share of common  stock of  Acquiror  ("Acquiror
Common Stock") equal to the exchange ratio, which is as follows:

            (a)         if the average of the reported  closing per share prices
                        of  Acquiror  Common  Stock on  NASDAQ  (or the last bid
                        price  in  the  absence  of  a  trade)   during  the  20
                        consecutive  trading days ending with and  including the
                        third trading day immediately  preceding the date of the
                        meeting of stockholders of the Company called to vote on
                        the Merger (the "Average Closing Price") is greater than
                        $49.87,   the  exchange  ratio  shall  be  the  quotient
                        obtained  by  dividing  $34.00  by the  Average  Closing
                        Price, rounded to the nearest 1/10,000;

            (b)         if the Average Closing Price of Acquiror Common Stock is
                        (a) less than or equal to $49.87 and (b) greater than or
                        equal to $33.00, the exchange ratio shall be 0.6818; and

            (c)         if the Average Closing Price of Acquiror Common Stock is
                        less  than  $33.00,  the  exchange  ratio  shall  be the
                        quotient  obtained  by  dividing  $22.50 by the  Average
                        Closing Price of Acquiror  Common Stock,  rounded to the
                        nearest 1/10,000.

In addition,  Acquiror will assume outstanding  options  exercisable for Company
Common Stock.

The  Merger is  intended  to be a  tax-free  reorganization  under the  Internal
Revenue  Code of 1986,  as amended,  and is intended  to be  accounted  for as a
pooling-of-interests.  The Merger is subject to approval by the  stockholders of
the Company, regulatory approvals and other closing conditions.

Also on November 30,  1999,  the Company  entered into a Stock Option  Agreement
with  Acquiror  (the  "Stock  Option  Agreement")  pursuant to which the Company
granted an option to  Acquiror to  purchase  up to  2,339,692  shares of Company
Common  Stock at a price of $30.00  per share  upon the  occurrence  of  certain
events related to termination of the Merger Agreement.  In addition, on November
30, 1999,  certain  affiliates  of the Company  entered  into voting  agreements
pursuant to which such  affiliates  agreed to vote all shares of Company  Common
Stock owned by them in favor of the Merger.

The foregoing  summary of certain  principal terms of the Merger  Agreement does
not purport to be complete  and is qualified in its entirety by reference to the
Merger  Agreement,  a copy of which is  attached  hereto as  Exhibit  2.1 and is
hereby incorporated by reference herein.

A copy of the  press  release  issued  by the  Company  on  December  1, 1999 is
attached hereto as Exhibit 2.2 and is hereby incorporated by reference herein.

A registration statement on Form S-4 (the "S-4 Registration Statement") relating
to the  Acquiror  Common  Stock to be issued in  connection  with the Merger and
containing  the  proxy   statement   relating  to  the  vote  of  the  Company's
stockholders on the Merger was filed with the Securities and Exchange Commission
("SEC") on December 10, 1999. The Acquiror Common Stock may not be offered,  nor
may  offers  to  acquire  such  Stock  be  accepted,  prior  to the time the S-4
Registration  Statement becomes  effective.  This Report shall not constitute an
offer to sell or the  solicitation  of an offer to buy any Acquiror Common Stock
or any other  security,  and shall not constitute the  solicitation  of any vote
with respect to the Merger.

This Current Report on Form 8-K contains  forward-looking  statements within the
meaning of Section 27A of the  Securities  Act of 1933, as amended,  and Section
21E of the  Securities  Exchange Act of 1934,  as amended.  The  forward-looking
statements  contained  herein involve risks and  uncertainties,  including those
relating to the possible  inability to complete the Merger as  scheduled,  if at
all, and those  associated  with the ability of the Acquiror,  subsequent to the
Merger,  to achieve the anticipated  benefits of the Merger.  Actual results and
developments  may differ  materially  from those  described or  incorporated  by
reference in this Report.  For more  information  about Acquiror and the Company
and risks  arising when  investing in Acquiror  and the Company,  investors  are
directed to the S-4 Registration Statement and Acquiror's and the Company's most
recent report, on Form 10-K and on Form 10-Q as filed with the SEC.


ITEM 7.  Financial Statements and Exhibits.

         (a)      Financial statements of businesses acquired.

                  Not applicable.

         (b)      Pro forma financial information.

                  Not applicable.

         (c)  Exhibits.

                  2.1      Agreement  and Plan of  Merger,  dated  November  30,
                           1999,  by and between King  Pharmaceuticals,  Inc., a
                           Tennessee   corporation   ("Acquiror"),   and   Medco
                           Research,   Inc.   (the   "Company"),    a   Delaware
                           corporation.

                  2.2      Stock Option  Agreement,  dated November 30, 1999, by
                           and between Acquiror and the Company.

                  2.3      Press  Release of the  Company,  issued  December  1,
                           1999.


SIGNATURES
Pursuant  to the  requirements  of the  Securities  Exchange  Act of  1934,  the
registrant  has duly  caused  this  report  to be  signed  on its  behalf by the
undersigned hereunto duly authorized.

                                                  MEDCO RESEARCH, INC.



                                             By:  /s/ Glenn C. Andrews
                                                -----------------------------
                                                  Glenn C. Andrews
                                                  Executive Vice President
                                                  and Chief Financial Officer

Dated: December 14, 1999








                          AGREEMENT AND PLAN OF MERGER
                                  BY AND AMONG
                           KING PHARMACEUTICALS, INC.,
                              MEDCO RESEARCH, INC.
                                       and
                           MERLIN ACQUISITION I CORP.










                          Dated as of November 30, 1999



<PAGE>
                                TABLE OF CONTENTS

                                                                        Page
                                                                        ----

                              ARTICLE I. THE MERGER

SECTION 1.1.                The Merger...................................2
SECTION 1.2.                Effective Time...............................2
SECTION 1.3.                Effect of the Merger.........................2
SECTION 1.4.                Certificate of Incorporation; Bylaws.........2
SECTION 1.5.                Directors and Officers.......................3
SECTION 1.6.                Closing......................................3
SECTION 1.7.                Subsequent Actions...........................3
SECTION 1.8.                Tax and Accounting Treatment of the Merger...4

         ARTICLE II. CONVERSION OF SECURITIES; EXCHANGE OF CERTIFICATES

SECTION 2.1.                Conversion of Securities.....................4
SECTION 2.2.                Exchange of Certificates.....................6
SECTION 2.3.                Assumption of Obligations to Issue Stock.....9
SECTION 2.4.                Transfer Books..............................10
SECTION 2.5.                Certain Adjustments.........................10

           ARTICLE III. REPRESENTATIONS AND WARRANTIES OF THE COMPANY

SECTION 3.1.                Organization and Qualification;
                            Subsidiaries................................11
SECTION 3.2.                Certificate of Incorporation and Bylaws.....12
SECTION 3.3.                Capitalization..............................12
SECTION 3.4.                Authority...................................13
SECTION 3.5.                No Conflict; Required Filings and Consents..14
SECTION 3.6.                SEC Filings; Financial Statements...........15
SECTION 3.7.                No Undisclosed Liabilities..................16
SECTION 3.8.                Absence of Certain Changes or Events........16
SECTION 3.9.                Absence of Litigation.......................17
SECTION 3.10.               Licenses and Permits; Compliance with Laws..17
SECTION 3.11.               Unlawful Payments...........................18
SECTION 3.12.               Taxes.......................................18
SECTION 3.13.               Intellectual Property.......................19
SECTION 3.14.               Material Contracts..........................21
SECTION 3.15.               Employee Benefit Plans......................22
SECTION 3.16.               Properties; Assets..........................24
SECTION 3.17.               Labor Relations.............................24
SECTION 3.18.               Environmental Matters.......................25
SECTION 3.19.               Insurance...................................26
SECTION 3.20.               Board Approval; Vote Required...............27
SECTION 3.21.               Opinion of Financial Advisor................27
SECTION 3.22.               Brokers.....................................27
SECTION 3.23.               Takeover Provisions Inapplicable............27
SECTION 3.24.               Pooling; Tax Matters........................28
SECTION 3.25.               Registration Statement; Proxy Statement/
                            Prospectus..................................28
SECTION 3.26.               Rights Agreement............................29
SECTION 3.27.               Regulatory Compliance.......................29
SECTION 3.28.               Current Cash Reserves; Indebtedness.........33
SECTION 3.29.               Transaction Expenses........................33
SECTION 3.30.               Disclosure..................................33

            ARTICLE IV. REPRESENTATIONS AND WARRANTIES OF MERGER SUB

SECTION 4.1.                Organization and Qualification..............33
SECTION 4.2.                Certificate of Incorporation and Bylaws.....34
SECTION 4.3.                Authority...................................34
SECTION 4.4.                No Conflict; Required Filings and Consents..34

              ARTICLE V. REPRESENTATIONS AND WARRANTIES OF ACQUIROR

SECTION 5.1.                Organization and Qualification;
                            Subsidiaries................................35
SECTION 5.2.                Certificate of Incorporation and Bylaws.....36
SECTION 5.3.                Capitalization..............................36
SECTION 5.4.                Authority...................................37
SECTION 5.5.                No Conflict; Required Filings and Consents..38
SECTION 5.6.                SEC Filings; Financial Statements...........39
SECTION 5.7.                No Undisclosed Liabilities..................39
SECTION 5.8.                Absence of Certain Changes or Events........40
SECTION 5.9.                Absence of Litigation.......................40
SECTION 5.10.               Licenses and Permits; Compliance with Laws..40
SECTION 5.11.               Unlawful Payments...........................40
SECTION 5.12.               Taxes.......................................41
SECTION 5.13.               Intellectual Property.......................41
SECTION 5.14.               Environmental Matters.......................41
SECTION 5.15.               Brokers.....................................43
SECTION 5.16.               Pooling; Tax Matters........................43
SECTION 5.17.               Registration Statement; Proxy Statement/
                            Prospectus..................................43
SECTION 5.18.               Disclosure..................................44

                              ARTICLE VI. COVENANTS

SECTION 6.1.                Affirmative Covenants of the Company........44
SECTION 6.2.                Negative Covenants of the Company...........45

                       ARTICLE VII. ADDITIONAL AGREEMENTS

SECTION 7.1.                Access and Information......................48
SECTION 7.2.                Confidentiality.............................49
SECTION 7.3.                Proxy Statement/Prospectus and Registration
                            Statement; Company Stockholders Meeting.....49
SECTION 7.4.                HSR Act Matters.............................50
SECTION 7.5.                Public Announcements........................51
SECTION 7.6.                Indemnification.............................51
SECTION 7.7.                Further Action; Commercially Reasonable
                            Efforts.....................................52
SECTION 7.8.                No Solicitation.............................53
SECTION 7.9.                Nasdaq Listing..............................55
SECTION 7.10.               Blue Sky....................................55
SECTION 7.11.               Affiliates..................................56
SECTION 7.12.               Event Notices...............................56
SECTION 7.13.               Option Agreement............................57
SECTION 7.14.               Tax Treatment...............................57
SECTION 7.15.               Accountant Letters; Pooling of Interests....57
SECTION 7.16.               Board of Directors of Acquiror..............58
SECTION 7.17.               Rights Agreement............................58
SECTION 7.18.               Exemption from Liability Under Section
                            16(b).......................................58
SECTION 7.19.               Requisite Acquiror Approval.................59

                        ARTICLE VIII. CLOSING CONDITIONS

SECTION 8.1.                Conditions to Obligations of Acquiror,
                            Merger Sub and the Company to Effect the
                            Merger......................................59
SECTION 8.2.                Additional Conditions to Obligations of
                            Acquiror and Merger Sub.....................61
SECTION 8.3.                Additional Conditions to Obligations of the
                            Company.....................................63
SECTION 8.4.                Delayed Closing by the Company..............64

                  ARTICLE IX. TERMINATION, AMENDMENT AND WAIVER

SECTION 9.1.                Termination.................................64
SECTION 9.2.                Effect of Termination.......................67
SECTION 9.3.                Amendment...................................68
SECTION 9.4.                Extension; Waiver...........................68

                          ARTICLE X. GENERAL PROVISIONS

SECTION 10.1                Effectiveness of Representations, Warranties
                            and Agreements..............................70
SECTION 10.2.               Notices.....................................70
SECTION 10.3.               Certain Definitions.........................71
SECTION 10.4.               Headings....................................74
SECTION 10.5.               Severability................................75
SECTION 10.6.               Entire Agreement............................75
SECTION 10.7.               Specific Performance........................75
SECTION 10.8.               Assignment..................................75
SECTION 10.9.               Third Party Beneficiaries...................75
SECTION 10.10.              Governing Law...............................76
SECTION 10.11.              Counterparts................................76



EXHIBITS

Exhibit A                  Company Affiliate Agreement
Exhibit B                  Acquiror Affiliate Agreement

SCHEDULES

Schedule 3.1               Subsidiaries and Ownership Interests of the Company
Schedule 3.3               Capitalization of the Company
Schedule 3.5               Filings and Consents
Schedule 3.8               Certain Changes or Events
Schedule 3.9               Litigation
Schedule 3.10              Licenses and Permits
Schedule 3.13              Intellectual Property
Schedule 3.14              Material Contracts
Schedule 3.15              Employee Benefit Plans
Schedule 3.15(f)           Other Tax Matters
Schedule 3.19              Insurance
Schedule 3.28              Excepted Encumbrances
Schedule 3.29              Transaction Expenses
Schedule 5.1               Subsidiaries and Ownership Interests of Acquiror
Schedule 5.3               Capitalization of Acquiror
Schedule 5.5               Filings and Consents
Schedule 5.9               Litigation
Schedule 7.11              Affiliates
Schedule 10.3(l)    Transaction Expenses
<PAGE>

                          AGREEMENT AND PLAN OF MERGER


THIS AGREEMENT AND PLAN OF MERGER (this  "Agreement")  is entered into this 30th
day of November, 1999, by and among MEDCO RESEARCH, INC., a Delaware corporation
(the   "Company"),   KING   PHARMACEUTICALS,   INC.,  a  Tennessee   corporation
("Acquiror"),  and  MERLIN  ACQUISITION  I CORP.,  a  Delaware  corporation  and
wholly-owned subsidiary of Acquiror ("Merger Sub").


                  WHEREAS,  each of the  Boards  of  Directors  of the  Company,
Acquiror and Merger Sub have each  determined  that it is advisable,  and in the
best interests of, their respective stockholders that Merger Sub, a wholly-owned
subsidiary  of Acquiror,  be merged with and into the  Company,  pursuant to and
subject to the terms and conditions of this  Agreement and the Delaware  General
Corporation Law ("Delaware Law");

                  WHEREAS,  concurrently with the execution and delivery of this
Agreement and as a condition and  inducement to the  willingness of Acquiror and
Merger Sub to enter into this Agreement,  certain  holders of common stock,  par
value $.001 per share, of the Company  ("Company  Common  Stock"),  have entered
into an agreement  with  Acquiror  (the "Voting  Agreement")  pursuant to which,
among other  things,  such  holders  have agreed to vote their shares of Company
Common Stock in favor of this  Agreement,  the Merger (as defined below) and the
other transactions contemplated by this Agreement;

                  WHEREAS,  concurrently with the execution and delivery of this
Agreement and as a condition and  inducement to the  willingness of Acquiror and
Merger Sub to enter into this  Agreement,  the Company and Acquiror have entered
into a Stock Option  Agreement  (the "Option  Agreement")  pursuant to which the
Company  has  granted to Acquiror  an  irrevocable  option to purchase  from the
Company up to a number of authorized but unissued shares of Company Common Stock
representing  19.9% of the outstanding  shares of Company Common Stock, upon the
terms and subject to the conditions set forth therein;

                  WHEREAS, for United States federal income tax purposes,  it is
intended that the Merger will qualify as a reorganization  within the meaning of
Section  368(a) of the Internal  Revenue Code of 1986,  as amended (the "Code");
and

                  WHEREAS,  for  accounting  purposes,  it is intended  that the
Merger shall be  accounted  for as a pooling of  interests  under United  States
generally accepted accounting principles ("GAAP").

<PAGE>

                  NOW,  THEREFORE,  in  consideration  of the  foregoing and the
respective  representations,  warranties,  covenants and agreements set forth in
this Agreement, the parties hereto agree as follows:

                                    ARTICLE I

                                   THE MERGER

         SECTION 1.1. The Merger.

                  Upon the terms and subject to the conditions set forth in this
Agreement,  and in  accordance  with  Delaware  Law, at the  Effective  Time (as
defined in Section  1.2)  Merger Sub shall be merged  with and into the  Company
(the "Merger").  As a result of the Merger, the separate corporate  existence of
Merger  Sub  shall  cease  and  the  Company  shall  continue  as the  surviving
corporation  of the  Merger  (sometimes  referred  to herein  as the  "Surviving
Corporation") and a wholly-owned subsidiary of Acquiror.

         SECTION 1.2. Effective Time.

                  As promptly as  practicable on the Closing Date (as defined in
Section 1.6),  the parties  hereto shall cause the Merger to be  consummated  by
filing a certificate of merger (the  "Certificate of Merger") with the Secretary
of State of the State of Delaware,  as required  by, and executed in  accordance
with the relevant  provisions  of,  Delaware Law and in such form as approved by
Acquiror  prior to such  filing  (the time of the filing of the  Certificate  of
Merger or the time specified therein being the "Effective Time").

         SECTION 1.3. Effect of the Merger.

                  At the  Effective  Time,  the effect of the Merger shall be as
provided in the  applicable  provisions  of Delaware Law.  Without  limiting the
generality of the foregoing,  and subject thereto, at the Effective Time, except
as otherwise provided herein, all the rights, privileges,  powers and franchises
of Merger Sub and the Company shall vest in the Surviving  Corporation,  and all
debts,  liabilities  and duties of Merger Sub and the Company  shall  become the
debts, liabilities and duties of the Surviving Corporation.

         SECTION 1.4 . Certificate of Incorporation; Bylaws.

                  At the Effective Time, (a) the certificate of incorporation of
Merger Sub, as in effect  immediately prior to the Effective Time and as amended
by the Certificate of Merger,  shall be the certificate of  incorporation of the
Surviving  Corporation,  and  (b)  the  bylaws  of  Merger  Sub,  as  in  effect
immediately  prior to the Effective  Time,  shall be the bylaws of the Surviving
Corporation.

         SECTION 1.5. Directors and Officers.

                  The directors of Merger Sub immediately prior to the Effective
Time shall be the initial directors of the Surviving  Corporation,  each to hold
office in accordance  with the  certificate of  incorporation  and bylaws of the
Surviving  Corporation;  and the officers of Merger Sub immediately prior to the
Effective Time shall be the officers of the Surviving Corporation,  in each case
until their respective successors are duly elected or appointed and qualified in
accordance  with the  certificate of  incorporation  and bylaws of the Surviving
Corporation.

         SECTION 1.6. Closing.

                  Subject to the terms and  conditions  of this  Agreement,  the
closing of the Merger (the "Closing") will take place as promptly as practicable
after  satisfaction  of the  latest to occur or, if  permissible,  waiver of the
conditions set forth in Article VIII hereof (the "Closing Date"), at the offices
of Hogan & Hartson L.L.P.,  8300 Greensboro Drive, Suite 1100, McLean,  Virginia
22102,  unless  another  date or place is agreed to in  writing  by the  parties
hereto.  It is the intention of the parties that the Closing shall occur as soon
as practicable after the Company Stockholders Meeting.

         SECTION 1.7. Subsequent Actions.

                  If,  at any time  after  the  Effective  Time,  the  Surviving
Corporation  shall  consider  or be  advised  that  any  deeds,  bills  of sale,
assignments,  assurances  or any  other  actions  or  things  are  necessary  or
desirable to continue in, vest, perfect or confirm of record or otherwise in the
Surviving  Corporation  its right,  title or interest in, to or under any of the
rights,  properties,   privileges,   franchises  or  assets  of  either  of  its
constituent corporations acquired or to be acquired by the Surviving Corporation
as a result of, or in connection with, the Merger or otherwise to carry out this
Agreement,  the officers and directors of the Surviving Corporation shall be and
hereby are directed and  authorized  to execute and deliver,  in the name and on
behalf of either of such  constituent  corporations,  all such  deeds,  bills of
sale,  assignments  and assurances and to take and do, in the name and on behalf
of each of such corporations or otherwise,  all such other actions and things as
may be necessary  or  desirable  to vest,  perfect or confirm any and all right,
title and  interest  in,  to and  under  such  rights,  properties,  privileges,
franchises or assets in the Surviving Corporation or otherwise to carry out this
Agreement.

         SECTION 1.8. Tax and Accounting Treatment of the Merger.

                  It is intended by the parties hereto that the Merger shall (a)
constitute a reorganization  of Merger Sub and the Company within the meaning of
Section  368(a) of the Code,  and (b) be accounted for as a pooling of interests
under  GAAP.   The  parties   hereby   adopt  this   Agreement  as  a  "plan  of
reorganization"  of Merger Sub and the  Company  within the  meaning of Sections
1.368-2(g) and 1.368-3(a) of the United States Treasury Regulations.

                                    ARTICLE II

               CONVERSION OF SECURITIES; EXCHANGE OF CERTIFICATES

         SECTION 2.1. Conversion of Securities.

                  At the Effective Time, by virtue of the Merger and without any
action on the part of Acquiror, Merger Sub, the Company or the holders of any of
the securities referred to in this Section 2.1:

                  (a)  Common  Stock.   Each  share  of  Company   Common  Stock
(excluding  any shares  described  in  Section  2.1(b))  issued and  outstanding
immediately  prior to the Effective Time shall cease to be outstanding and shall
be converted into and exchanged for the right to receive a portion of a share of
common stock, no par value, of Acquiror  ("Acquiror  Common Stock") equal to the
Exchange Ratio (as defined below).  The shares of Acquiror Common Stock issuable
to the holders of Company Common Stock pursuant hereto, together with the amount
of cash in lieu of fractional  shares  payable  pursuant to Section  2.1(d),  is
sometimes referred to herein, collectively,  as the "Merger Consideration".  All
such shares of Company  Common  Stock shall  cease to be  outstanding  and shall
automatically  be  canceled  and  retired  and shall  cease to  exist,  and each
certificate  previously  evidencing any such shares shall  thereafter  represent
only the right to receive the Merger Consideration. Except as otherwise provided
herein or by applicable law, the holders of certificates  previously  evidencing
such  shares  of  Company  Common  Stock  outstanding  immediately  prior to the
Effective  Time shall  cease to have any rights  with  respect to such shares of
Company Common Stock. Each such certificate previously evidencing such shares of
Company  Common  Stock shall be  exchanged  for the number of shares  previously
evidenced by the canceled  certificate upon the surrender of such certificate in
accordance with the provisions of Section 2.2 multiplied by the Exchange Ratio.

                           The "Exchange Ratio" shall be as follows:

                           (i) if the Average  Closing Price (as defined  below)
         shall be greater than $49.87,  the Exchange Ratio shall be the quotient
         obtained by dividing  $34.00 by the Average  Closing Price,  rounded to
         the nearest 1/10,000;

                           (ii) if the Average  Closing  Price shall be (A) less
         than or equal to $49.87 and (B)  greater  than or equal to $33.00,  the
         Exchange Ratio shall be 0.6818; and

                           (iii) if the Average Closing Price shall be less than
         $33.00,  the Exchange Ratio shall be the quotient  obtained by dividing
         $22.50 by the Average Closing Price, rounded to the nearest 1/10,000.

                  "Average Closing Price" shall mean the average of the reported
closing prices per share of Acquiror Common Stock on the National Association of
Securities Dealers Automated Quotation  System/National Market System ("Nasdaq")
(or the last bid  price  in the  absence  of a trade)  during  the  twenty  (20)
consecutive  trading  days  ending  with and  including  the third  trading  day
immediately preceding the date of the Company Stockholders Meeting.

                  (b) Treasury Stock. All shares of capital stock of the Company
held in the  treasury of the Company  immediately  prior to the  Effective  Time
shall be canceled and extinguished  without any conversion thereof and no amount
shall be delivered or deliverable in exchange therefor.

                  (c) Merger Sub Stock.  Each share of common  stock,  par value
$.01 per share,  of Merger Sub issued and outstanding  immediately  prior to the
Effective  Time  shall  be  converted  into and  exchanged  for one (1) duly and
validly  issued,  fully  paid and  nonassessable  share of  common  stock of the
Surviving Corporation.

                  (d) No Fractional Shares. No certificate or scrip representing
any  fractional  shares of Acquiror  Common  Stock  shall be issued  pursuant to
Section 2.1(a), and other than the right to receive the cash payment pursuant to
this Section 2.1(d),  any such fractional  interests shall not entitle the owner
thereof to any rights as a securityholder of Acquiror. Notwithstanding any other
provision  hereof,  all holders of Company  Common Stock  otherwise  entitled to
receive  fractional  shares of Acquiror  Common Stock pursuant to Section 2.1(a)
shall be entitled to receive,  in lieu thereof,  cash  (without  interest) in an
amount equal to the product of (i) such  fractional  part of a share of Acquiror
Common  Stock to which the holder of Company  Common  Stock would  otherwise  be
entitled  under  Section  2.1(a)  multiplied  by the closing  price per share of
Acquiror  Common Stock on the Closing  Date.  As promptly as possible  after the
determination  of the  amount  of  cash  to be paid  to  holders  of  fractional
interests, the Exchange Agent shall so notify Acquiror, and Acquiror shall cause
the  Surviving  Corporation  to deposit such amount with the Exchange  Agent and
shall cause the Exchange Agent to forward payments to holders of such fractional
interests subject to and in accordance with the terms hereof.

         SECTION 2.2. Exchange of Certificates.

                  (a) Exchange  Agent. As soon as reasonably  practicable  after
the  Effective  Time,  Acquiror  shall  deposit with Union  Planters  Bank or an
exchange agent  designated by Acquiror and reasonably  acceptable to the Company
(the  "Exchange  Agent"),  for the  benefit of the  former  holders of shares of
Company Common Stock  (excluding any shares  described in Section  2.1(b)),  for
issuance  and  payment  in  accordance  with this  Article  II (i) the shares of
Acquiror  Common Stock  issuable  pursuant to Section 2.1(a) and (ii) cash in an
amount  sufficient to make payment for  fractional  shares under Section  2.1(d)
(such shares of Acquiror Common Stock and cash being hereinafter  referred to as
the  "Exchange  Fund").  Acquiror  shall cause the Exchange  Agent,  pursuant to
irrevocable  instructions,  to  deliver  Acquiror  Common  Stock  (and  cash for
fractional  shares)  contemplated to be paid pursuant to Sections 2.1(a) and (d)
out of the Exchange  Fund.  The Exchange  Fund shall not be used for any purpose
other than as set forth in this Section 2.2(a).

                  (b)  Payment  Procedures.  As soon as  reasonably  practicable
after the Effective  Time,  Acquiror  shall cause the Exchange  Agent to mail to
each record holder,  as of the Effective Time, of an outstanding  certificate or
certificates (each a "Certificate" and collectively,  the  "Certificates")  that
immediately prior to the Effective Time evidenced  outstanding shares of Company
Common Stock  (excluding any shares  described in Sections  2.1(b)):  (i) a form
letter of transmittal and (ii)  instructions  for use in effecting the surrender
of the Certificates for payment  therefor.  Upon surrender to the Exchange Agent
of a Certificate, together with such letter of transmittal duly executed and any
other required  documents,  the holder of such Certificate  shall be entitled to
receive in  exchange  therefor  the  applicable  amount of Merger  Consideration
pursuant  to  Section  2.1(a) and  Section  2.1(d)  and any  dividends  or other
distributions to which such holder is entitled  pursuant to Section 2.2(j),  and
such Certificate  shall forthwith be canceled.  In the event of a surrender of a
Certificate representing shares of Company Common Stock which are not registered
in the transfer records of the Company under the name of the Person surrendering
such  Certificate,  a  certificate  representing  the proper number of shares of
Acquiror  Common  Stock may be issued to a Person other than the Person in whose
name the Certificate so surrendered is registered if (x) such Certificate  shall
be properly  endorsed or  otherwise be in proper form for transfer to the Person
surrendering  such  Certificate  and requesting  such issuance,  (y) such Person
surrendering  such  Certificate  and  requesting  such  issuance  shall  pay any
transfer or other Taxes required by reason of the issuance of shares of Acquiror
Common Stock to a Person other than the registered holder of such Certificate or
shall  establish to the  satisfaction of Acquiror that such Taxes have been paid
or are not applicable,  and (z) such Person surrendering such Certificate shall,
if required by Acquiror,  have such  Person's  signature  guaranteed  by a bank,
brokerage firm or other financial  intermediary  that is a member of a medallion
guarantee  program.  Until surrendered in accordance with the provisions of this
Section 2.2, each Certificate shall represent for all purposes only the right to
receive  the  applicable  consideration  set forth in Section  2.1,  without any
interest thereon.

                  (c) Issuances to Affiliates.  Notwithstanding  anything herein
to the contrary, any Certificate  surrendered for exchange by any "affiliate" of
the Company (as that term is used in SEC Accounting  Series Release Nos. 130 and
135 and Rule 145 of the rules and  regulations  of the SEC under the  Securities
Act)  shall  not be  exchanged  until  Acquiror  shall  have  received  a signed
agreement from such "affiliate" as provided in Section 7.11 hereof.

                  (d) No Further Rights in Stock.  All shares of Acquiror Common
Stock issued upon the surrender for exchange of  Certificates in accordance with
the terms of Sections 2.1 and 2.2 hereof  (including  any cash paid  pursuant to
this  Article  II)  shall be  deemed  to have  been  issued  (and  paid) in full
satisfaction  of all rights  pertaining  to the shares of Company  Common  Stock
theretofore  represented  by such  Certificates,  and there  shall be no further
registration   of  transfer  on  the  stock  transfer  books  of  the  Surviving
Corporation  of  the  shares  of  Company  Common  Stock   represented  by  such
Certificates which were outstanding immediately prior to the Effective Time. If,
after the Effective Time, any such  Certificates are presented to Acquiror,  the
Surviving  Corporation  or the  Exchange  Agent for any  reason,  they  shall be
canceled  and  exchanged  as provided in this  Article II,  except as  otherwise
provided by law.

                  (e)  Investment  of Exchange  Fund.  The Exchange  Agent shall
invest any cash  included in the Exchange  Fund,  as directed by Acquiror,  on a
daily basis. Any interest and other income resulting from such investments shall
be paid to Acquiror.

                  (f)  Termination of Exchange Fund. Any portion of the Exchange
Fund that remains  undistributed  to the holders of Company Common Stock for one
hundred  eighty  (180)  days after the  Effective  Time  shall be  delivered  to
Acquiror,  upon  demand,  and any holder of Company  Common  Stock that have not
theretofore  complied  with this  Article II shall  thereafter  look only to the
Acquiror for the Merger  Consideration to which such holder is entitled pursuant
hereto.

                  (g)  No   Liability.   Neither   Acquiror  nor  the  Surviving
Corporation  shall be liable to any holder of shares of Company Common Stock for
any Acquiror Common Stock or cash delivered to a public official pursuant to any
applicable abandoned property, escheat or similar law.

                  (h)  Withholding of Tax.  Acquiror or the Exchange Agent shall
be  entitled to deduct and  withhold  from the  applicable  amount of the Merger
Consideration  otherwise issuable to, and any cash payment in lieu of fractional
shares  otherwise  payable  pursuant to this  Agreement to, any former holder of
Company Common Stock such amounts as Acquiror (or any Affiliate  thereof) or the
Exchange Agent are required to deduct and withhold with respect to the making of
such payment  under the Code,  or any  provision of state,  local or foreign Tax
law. To the extent that  amounts are so withheld by Acquiror  (or any  Affiliate
thereof) or the Exchange Agent,  such withheld  amounts shall be treated for all
purposes of this  Agreement as having been paid to the former  holder of Company
Common  Stock in  respect of whom such  deduction  and  withholding  was made by
Acquiror (or any Affiliate thereof) or the Exchange Agent.

                  (i) Lost, Stolen or Destroyed  Certificates.  In the event any
Certificate  evidencing  shares of Company  Common  Stock  shall have been lost,
stolen or destroyed,  upon the making of an affidavit setting forth that fact by
the Person claiming such lost, stolen or destroyed  Certificate and, if required
by Acquiror  the posting by such Person of a bond in such  reasonable  amount as
Acquiror  may direct as  indemnity  against  any claim that may be made  against
Acquiror,  the Surviving  Corporation or the Exchange Agent with respect to such
Certificate,  Acquiror  shall cause the Exchange Agent to pay to such Person the
applicable amount of the Merger  Consideration with respect to such lost, stolen
or destroyed Certificate.

                  (j) Distributions  With Respect to Unexchanged  Company Common
Stock.  No  dividends  or other  distributions  declared or made with respect to
Acquiror  Common Stock with a record date after the Effective Time shall be paid
to the holder of any  unsurrendered  Certificate  with  respect to the shares of
Acquiror Common Stock such holder is entitled to receive pursuant to Section 2.1
until such holder shall  surrender such  Certificate.  Subject to applicable law
and the  provisions  of this  Article II,  following  the  surrender of any such
Certificate  there shall be paid to the record  holder of the shares of Acquiror
Common Stock issued in exchange for such Certificate,  without interest,  at the
time of such surrender,  the amount of dividends or other  distributions  with a
record  date after the  Effective  Time  theretofore  paid with  respect to such
shares of Acquiror Common Stock.

         SECTION 2.3. Assumption of Obligations to Issue Stock.

                  (a)  Company  Options.  As of the  Effective  Time,  (i)  each
outstanding  option to purchase or acquire  shares of Company  Common  Stock (an
"Option")  granted under the Company's 1989 Stock Option and Stock  Appreciation
Rights Plan (the "Company  Stock Option Plan") shall be converted into an option
to acquire  Acquiror  Common Stock as provided for in this Section  2.3(a),  and
(ii) each such option shall become  vested as provided for in the Company  Stock
Option Plan and this Agreement.  Following the Effective Time, each Option shall
continue  to have,  and shall be subject  to, the terms and  conditions  of each
agreement  pursuant to which such Option was  subject as of the  Effective  Time
(including  the terms and  conditions of the Company Stock Option Plan),  except
that (i) each Option  shall be  exercisable  for that number of whole  shares of
Acquiror Common Stock equal to the product of (A) the aggregate number of shares
of Company  Common Stock for which such Option was  exercisable at the Effective
Time multiplied by (B) the Exchange Ratio, provided, however, that no fractional
shares of Acquiror  Common Stock shall be issued upon the exercise of any Option
converted  pursuant  to  this  Section  2.3(a),  and  the  holder  of an  Option
exercisable for a fractional share of Acquiror Common Stock shall be entitled to
receive,  upon exercise thereof, cash (without interest) in an amount equivalent
to the fair  market  value at the time of exercise  of the  fractional  share of
Acquiror Common Stock to which such holder would otherwise be entitled; and (ii)
the exercise price per share of Acquiror Common Stock issuable  pursuant to each
Option  shall be equal to the exercise  price per share of Company  Common Stock
under such Option at the Effective Time divided by the Exchange  Ratio,  rounded
to the nearest  whole cent.  Except for changes to the  Options,  including  the
acceleration thereof, provided for in the Company Stock Option Plan by reason of
the consummation of the  transactions  contemplated  hereby,  the assumption and
substitution  of Options as provided  herein  shall not give the holders of such
Options additional benefits or additional (or accelerated)  vesting rights which
they did not have as of the  Effective  Time,  or  relieve  the  holders of such
Options of any  obligations or  restrictions  applicable to their Options or the
shares  obtainable  upon exercise of the Options.  The  adjustment  provided for
herein with  respect to any  Options  that are  "incentive  stock  options"  (as
defined  in  Section  422 of the Code)  shall be  effected  in a manner  that is
consistent with continued treatment of such Options as "incentive stock options"
under Section 424(a) of the Code. The Company Stock Option Plan shall be assumed
by Acquiror with respect to all  outstanding  Options  granted under the Company
Stock  Option  Plan,  and no further  options to purchase  or acquire  shares of
Company  Common  stock or other  awards or  rights  shall be  granted  under the
Company Stock Option Plan after the Effective Time. The duration and other terms
of the new options  provided for in this Section 2.3(a) shall be the same as the
original  Options  except that all references to the Company shall be references
to Acquiror.  Acquiror shall take all corporate action  reasonably  necessary to
reserve for issuance a sufficient  number of shares of Acquiror Common Stock for
delivery upon the exercise of the Options.

                  (b) Form S-8. Acquiror shall (i) within ten (10) business days
after the Effective Time, file one or more  registration  statements on Form S-8
(or amend existing  registration  statements on Form S-8) to become effective as
soon as  practicable  after the  Effective  Time with  respect  to the shares of
Acquiror  Common Stock subject to Options granted under the Company Stock Option
Plan (as converted pursuant to Section 2.3(a)); (ii) use commercially reasonable
efforts to maintain the  effectiveness of such  registration  statement(s)  (and
maintain the current status of the prospectus or prospectuses contained therein)
for so long as such  Options  remain  outstanding;  and  (iii)  within  ten (10)
business  days  after  the  Effective   Time,   prepare  and  submit  to  Nasdaq
applications  covering  the  shares of  Acquiror  Common  Stock  subject to such
Options and use commercially  reasonable  efforts to cause such securities to be
approved for listing as soon as practicable after the Effective Time, subject to
official notice of issuance.

         SECTION 2.4. Transfer Books.

                  At the Effective  Time, the transfer books of the Company with
respect to all shares of capital stock and other securities of the Company shall
be closed and no further  registration  of  transfers  of such shares of capital
stock shall  thereafter  be made on the records of the Company.  On or after the
Effective  Time,  if  any  Certificates  for  shares  of  Company  Common  Stock
(excluding any shares described in Section 2.1(b)) are presented to the Exchange
Agent, the Surviving  Corporation or Acquiror for any reason,  such Certificates
shall be  canceled  and  exchanged  as provided  in this  Article II,  except as
otherwise provided by law.

         SECTION 2.5. Certain Adjustments.

                  If  between  the  date  hereof  and the  Effective  Time,  the
outstanding  shares of Company Common Stock or of Acquiror Common Stock shall be
changed  into a  different  number of shares by reason of any  reclassification,
recapitalization,  split-up,  combination or exchange of shares, or any dividend
payable in stock or other  securities  shall be declared  thereon  with a record
date within such period,  the Exchange Ratio (and any other references herein to
a price per share of Acquiror  Common  Stock) shall be adjusted  accordingly  to
provide the same economic effect as contemplated by this Agreement prior to such
reclassification, recapitalization, split-up, combination, exchange or dividend.

                                   ARTICLE III

                 REPRESENTATIONS AND WARRANTIES OF THE COMPANY

                  The Company  hereby  represents  and  warrants to Acquiror and
Merger Sub,  subject to the  exceptions  set forth in the  Company's  disclosure
schedule (which exceptions shall specifically identify a section,  subsection or
clause of a single section or subsection  hereof,  as applicable,  to which such
exception relates, it being understood and agreed that each such exception shall
be deemed to be disclosed  both under such section,  subsection or clause hereof
and any other  section,  subsection  or clause  hereof to which such  disclosure
reasonably relates) that:

         SECTION 3.1. Organization and Qualification; Subsidiaries.

                  (a) Each of the Company and each Subsidiary (as defined below)
of the Company  (each a "Company  Subsidiary"  and  collectively,  the  "Company
Subsidiaries")  is a corporation  duly organized,  validly  existing and in good
standing under the laws of the  jurisdiction  of its  organization.  Each of the
Company and each Company  Subsidiary is duly  qualified to conduct its business,
and is in good  standing,  in  each  jurisdiction  where  the  character  of its
properties owned,  operated or leased or the nature of its activities makes such
qualification  necessary,  except for such failures which have not had and would
not be reasonably likely to have a Material Adverse Effect on the Company.  Each
of the Company and each Company Subsidiary has the requisite corporate power and
authority and any necessary governmental authority, franchise, license or permit
to own,  operate,  lease  and  otherwise  to hold and  operate  its  assets  and
properties  and to carry on its  businesses as now being  conducted,  except for
such failures  which have not had and would not be  reasonably  likely to have a
Material  Adverse  Effect on the Company.  The Company has no  Subsidiaries  (as
defined  below)  other  than  those  listed in  Schedule  3.1,  each of which is
wholly-owned by the Company, or any direct or indirect  beneficial  ownership of
any  securities,  equity or other  ownership  interest in any Person  other than
those listed on Schedule 3.1.

                  (b) For  purposes of this  Agreement,  a  "Subsidiary"  of any
Person means any corporation,  partnership,  joint venture or other legal entity
of which  such  Person  (either  alone or  through  or  together  with any other
Subsidiary of such Person) (i) owns, directly or indirectly, fifty percent (50%)
or more of the capital stock,  partnership  interests or other equity  interests
the  holders of which are  generally  entitled  to vote for the  election of the
board of directors or other  governing  body of such  corporation,  partnership,
joint venture or other legal entity; or (ii) possesses,  directly or indirectly,
control  over the  direction  of  management  or policies  of such  corporation,
partnership,  joint venture or other legal entity (whether through  ownership of
voting securities, by agreement or otherwise).

         SECTION 3.2. Certificate of Incorporation and Bylaws.

                  The Company has  heretofore  delivered  to Acquiror a complete
and correct copy of the certificate or articles of incorporation  and the bylaws
of the Company and each Company Subsidiary,  each as amended to the date of this
Agreement.  Each such certificate or articles of incorporation  and bylaws is in
full force and effect.  Neither the  Company  nor any Company  Subsidiary  is in
violation of any of the provisions of its respective  certificate or articles of
incorporation or bylaws.

         SECTION 3.3. Capitalization.

                  (a) The  authorized  capital stock of the Company  consists of
forty million  (40,000,000)  shares of Company  Common Stock and twenty  million
(20,000,000)  shares of  preferred  stock,  par value  $.001 per  share,  of the
Company ("Company  Preferred Stock").  As of the date hereof: (i) eleven million
seven hundred  fifty-seven  thousand two hundred seventy  (11,757,270) shares of
Company Common Stock are issued and  outstanding;  (ii) one million  twenty-four
thousand three hundred fifty-six (1,024,356) shares of Company Common Stock have
been  reserved for issuance  upon the exercise of the options  under the Company
Stock  Option  Plan;  (iii) one  million  seventy-four  thousand  three  hundred
(1,074,300)  shares  of  Company  Common  Stock are held by the  Company  in the
Company's  treasury and (iv) no shares of Company  Preferred Stock are issued or
outstanding. Schedule 3.3 sets forth a complete and correct list, as of the date
hereof,  of the number of shares of Company Common Stock subject to the Options,
including,  without limitation, those subject to employee stock options or other
rights to purchase or receive  Company  Common Stock  granted  under the Company
Stock Option Plan in each case including the dates of grant and exercise  prices
thereof.

                  (b) All  outstanding  shares of capital  stock of the  Company
are, and all shares which may be issued will be, when issued,  duly  authorized,
validly  issued,  fully paid and  nonassessable  and not  subject to  preemptive
rights.  Except for the shares of Company Common Stock issuable  pursuant to the
Option  Agreement and shares of Company  Common Stock  issuable upon exercise of
the rights (the "Rights")  distributed pursuant to the Rights Agreement dated as
of April 14,  1998,  between  the Company and  American  Stock  Transfer & Trust
Company (the "Rights  Agreement") to holders of Company Common Stock pursuant to
the  Rights  Agreement,  (i) there are not  issued,  reserved  for  issuance  or
outstanding  (A) any shares of capital  stock or other voting  securities of the
Company, (B) any securities of the Company or any Company Subsidiary convertible
into or  exchangeable  or  exercisable  for  shares of  capital  stock or voting
securities or ownership interests of the Company or any Company Subsidiary,  (C)
any warrants,  calls, options or other rights to acquire from the Company or any
Company Subsidiary,  and any obligation of the Company or any Company Subsidiary
to issue, any capital stock,  voting securities or other ownership interests in,
or securities  convertible into or exchangeable or exercisable for capital stock
or voting  securities  of, or other  ownership  interests in, the Company or any
Company Subsidiary,  (ii) there are no outstanding obligations of the Company or
any Company  Subsidiary  to  repurchase,  redeem or  otherwise  acquire any such
securities  or to issue,  deliver or sell,  or cause to be issued,  delivered or
sold, any such securities, including, without limitation, any offer, issuance or
sale in such a manner that would  constitute  a public  offering  of  securities
under the Securities  Act, and (iii) except as  contemplated  in this Agreement,
the Company is not presently under any obligation,  has not agreed or committed,
and has not granted rights, to register under the Securities Act or the Exchange
Act,  or  otherwise  file any  registration  statement  under  any such  statute
covering,  any of its currently outstanding capital stock or other securities or
any of its capital stock or other securities that may be subsequently issued.

                  (c)  Except for the Option  Agreement,  the option  agreements
under the  Company  Stock  Option  Plan and the Rights  Agreement,  neither  the
Company nor any Company  Subsidiary is a party to any agreement  restricting the
purchase or transfer of, relating to the voting of or granting any preemptive or
antidilutive rights with respect to, any securities of the Company or any of the
Company  Subsidiaries  that are outstanding or that may be  subsequently  issued
upon the conversion or exercise of any instrument or otherwise.

                  (d) The Company represents and warrants to Acquiror and Merger
Sub that on the Closing Date,  the  aggregate  number of  outstanding  shares of
Company  Common Stock on a fully  diluted basis  (assuming  full exercise of the
Options) shall not exceed twelve million seven hundred  eighty-one  thousand six
hundred twenty-six (12,781,626) shares.

         SECTION 3.4. Authority.

                  The Company has the necessary corporate power and authority to
enter into this  Agreement and,  subject to obtaining the requisite  approval of
the Agreement by the Company's  stockholders  required by Delaware Law ("Company
Stockholder  Approval"),  to perform its obligations hereunder and to consummate
the transactions  contemplated hereby.  Except for Company Stockholder Approval,
the execution and delivery of this Agreement by the Company and the consummation
by the  Company  of the  transactions  contemplated  hereby  have  been duly and
validly  authorized by all  necessary  corporate  action and no other  corporate
proceedings on the part of the Company are necessary to authorize this Agreement
or to consummate the transactions  contemplated  hereby. This Agreement has been
duly executed and delivered by the Company and, assuming the due  authorization,
execution and delivery by Acquiror and Merger Sub,  constitutes  a legal,  valid
and binding obligation of the Company, enforceable in accordance with its terms,
except  as  such  enforceability  may  be  limited  by  bankruptcy,  insolvency,
reorganization,  moratorium  and other  similar  laws of  general  applicability
relating to or affecting  creditors'  rights generally and by the application of
general principles of equity.

         SECTION 3.5. No Conflict; Required Filings and Consents.

                  (a)  The  execution  and  delivery  of this  Agreement  by the
Company do not, and the performance by the Company of its obligations under this
Agreement will not, (i) conflict with or violate the  certificate or articles of
incorporation or bylaws of the Company or any Company  Subsidiary,  (ii) subject
to obtaining the approvals and  compliance  with the  requirements  set forth in
Section  3.5(b),  conflict with or violate any law,  statute,  ordinance,  rule,
regulation,  order,  judgment or decree applicable to the Company or any Company
Subsidiary or by which any of their respective  properties or assets is bound or
affected,  or (iii) except as set forth in Schedule 3.5, result in any breach of
or  constitute  a default (or an event which with or without  notice or lapse of
time or both  would  become a  default)  under,  or give to others any rights of
termination,  amendment,  acceleration  or  cancellation  of,  or  result in the
creation of an  Encumbrance on any of the properties or assets of the Company or
any  Company  Subsidiary  pursuant  to,  any note,  bond,  mortgage,  indenture,
contract,  agreement,  lease, license,  permit, franchise or other instrument or
obligation to which the Company or any Company Subsidiary is a party or by which
the Company,  any Company  Subsidiary or any of their  respective  properties or
assets  is bound or  affected,  except,  in the case of  clauses  (ii) and (iii)
above,  for  any  such  conflicts,   violations,  breaches,  defaults  or  other
alterations or occurrences  that (A) would not prevent or delay  consummation of
the Merger in any  material  respect  or  otherwise  prevent  the  Company  from
performing its obligations under this Agreement in any material respect, and (B)
have not had and  would not be  reasonably  likely  to have a  Material  Adverse
Effect on the Company.

                  (b)  The  execution  and  delivery  of this  Agreement  by the
Company do not, and the  performance  of this Agreement by the Company will not,
require any  consent,  approval,  authorization  or permit of, or filing with or
notification to, any governmental or regulatory  authority,  domestic or foreign
(each a "Governmental Entity"), by or with respect to the Company or any Company
Subsidiary,  except  (i)  for  (A)  applicable  requirements,  if  any,  of  the
Securities Exchange Act of 1934, as amended (the "Exchange Act"), the Securities
Act of 1933, as amended (the "Securities  Act"),  state securities or "blue sky"
laws  ("Blue Sky  Laws"),  state  takeover  laws,  the New York  Stock  Exchange
("NYSE")  and the  Hart-Scott-Rodino  Antitrust  Improvements  Act of  1976,  as
amended (the "HSR Act") and the U.S. Food and Drug  Administration  (the "FDA"),
(B) applicable requirements, if any, of the consents, approvals,  authorizations
or  permits  described  in  Schedule  3.5,  and (C) filing  and  recordation  of
appropriate merger documents as required by Delaware Law, and (ii) where failure
to obtain such consents,  approvals,  authorizations or permits, or to make such
filings or  notifications,  (A) would not prevent or delay  consummation  of the
Merger in any material respect or otherwise  prevent the Company from performing
its obligations  under this Agreement in any material  respect,  or (B) have not
had and would not be reasonably  likely to have a Material Adverse Effect on the
Company.

                  (c) Except as set forth on Schedule  3.5,  the  execution  and
delivery  of this  Agreement  by the  Company do not,  the  performance  of this
Agreement  by the Company  will not, and the  consummation  of the  transactions
contemplated by this Agreement or the Option Agreement will not, (i) entitle any
current or former  employee or officer of the Company or any ERISA  Affiliate to
severance pay,  unemployment  compensation or any other payment, (ii) accelerate
the time of payment or vesting, or increase the amount of compensation,  due any
such employee or officer,  or (iii) except  pursuant to the Company Stock Option
Plan  accelerate  the vesting of any stock option or of any shares of restricted
stock or other securities of the Company.

         SECTION 3.6. SEC Filings; Financial Statements.

                  (a) The Company has filed all forms,  reports,  statements and
other documents required to be filed with the Securities and Exchange Commission
(the "SEC") since January 1, 1995, and has heretofore furnished to Acquiror,  in
the form  filed  with the SEC since  such  date,  together  with any  amendments
thereto,  all of its (i) Annual Reports on Form 10-K, (ii) Quarterly  Reports on
Form 10-Q, (iii) proxy statements relating to meetings of stockholders  (whether
annual  or  special),  (iv)  reports  on Form  8-K,  and (v)  other  reports  or
registration  statements  filed by the Company  (collectively,  the "Company SEC
Reports").  As of their  respective  filing  dates,  the Company SEC Reports (x)
complied  as to form in all  material  respects  with  the  requirements  of the
Exchange Act and the Securities Act, as applicable,  and (y) did not at the time
they were filed contain any untrue statement of a material fact or omit to state
a  material  fact  required  to be  stated  therein  or  necessary  to make  the
statements  therein,  in the light of the  circumstances  under  which they were
made, not misleading.

                  (b)  The  audited   consolidated   financial   statements  and
unaudited  interim  financial  statements of the Company included in the Company
SEC  Reports  complied  in all  material  respects  with  applicable  accounting
requirements  and with  the  published  rules  and  regulations  of the SEC with
respect  thereto.  The  financial  statements,  including  all related notes and
schedules,  contained in the Company SEC Reports (or  incorporated  by reference
therein)  present  fairly in all material  respects the  consolidated  financial
position of the Company and the Company  Subsidiaries as at the respective dates
thereof and the consolidated results of operations and cash flows of the Company
and the Company Subsidiaries for the periods indicated,  in accordance with GAAP
applied on a consistent  basis throughout the periods involved (except as may be
noted therein) and subject in the case of interim financial statements to normal
year-end adjustments.

         SECTION 3.7. No Undisclosed Liabilities.

                  Neither the Company  nor any of the Company  Subsidiaries  has
any liabilities or obligations of any nature, whether or not accrued, contingent
or otherwise, except (a) liabilities or obligations reflected in the Company SEC
Reports through the date of the filing of the Company's Quarterly Report on Form
10-Q in respect of the fiscal quarter ending September 30, 1999, (b) liabilities
or obligations  incurred in the ordinary course of business consistent with past
practice  since  September  30,  1999 which have not had,  and will not have,  a
Material Adverse Effect on the Company and (c) liabilities or obligations  which
have not had and are not reasonably  likely to have a Material Adverse Effect on
the Company.

         SECTION 3.8. Absence of Certain Changes or Events.

                  Since   September  30,  1999,  the  Company  and  the  Company
Subsidiaries  have  conducted  their  businesses  only  in the  ordinary  course
consistent  with past  practice,  and except as set forth on Schedule 3.8, there
has  not  been  (i)  any  Material  Adverse  Effect  on the  Company,  (ii)  any
declaration,  setting  aside or payment of any  dividend  or other  distribution
(whether  in cash,  stock or  property)  with  respect  to any of the  Company's
capital stock, (iii) any split,  combination or  reclassification  of any of the
Company's  capital stock or any issuance or the authorization of any issuance of
any other  securities in respect of, in lieu of or in substitution for shares of
its  capital  stock,  (iv)  (w)  any  granting  by the  Company  or any  Company
Subsidiary to any current or former director, officer or employee of the Company
or any of the Company  Subsidiaries  of any increase in  compensation,  bonus or
other  benefits,  except for normal  increases in cash  compensation  and annual
stock option awards  granted on November 12, 1999 (as set forth on Schedule 3.8)
in the  ordinary  course of  business  consistent  with past  practice,  (x) any
granting by the Company or any of the Company  Subsidiaries  to any such current
or former  director,  officer  or  employee  of any  increase  in  severance  or
termination pay, (y) any entry by the Company or any of the Company Subsidiaries
into, or any amendment of, any employment,  deferred  compensation,  consulting,
severance,  termination  or  indemnification  agreement with any such current or
former  director,  officer or employee or (z) any amendment to, or  modification
of, any Option,  (v) any damage,  destruction or loss, whether or not covered by
insurance,  that would be reasonably likely to have a Material Adverse Effect on
the Company,  (vi) any change in accounting methods,  principles or practices by
the Company materially affecting its assets,  liabilities or businesses,  except
insofar as may have been required by a change in GAAP, or (vii) any Tax election
that would be reasonably likely to have a Material Adverse Effect on the Company
or any of its tax  attributes  or any  settlement  or compromise of any material
income tax liability.

         SECTION 3.9. Absence of Litigation.

                  Except as set forth on Schedule 3.9 and except as set forth in
the  Company's  annual report on Form 10-K filed with the SEC on March 16, 1999,
there are (a) no claims, actions, suits, investigations,  or proceedings pending
or, to the  knowledge  of the  Company,  threatened  against  the Company or any
Company  Subsidiary before any court,  administrative,  governmental,  arbitral,
mediation or regulatory  authority or body,  domestic or foreign,  that would be
reasonably  likely to have a  Material  Adverse  Effect on the  Company  or that
challenge or seek to prevent, enjoin, alter or materially delay the transactions
contemplated hereby or by the Option Agreement,  and (b) no judgments,  decrees,
injunctions  or orders of any  Governmental  Entity  or  arbitrator  outstanding
against the Company or any Company Subsidiary.

         SECTION 3.10. Licenses and Permits; Compliance with Laws.

                  Set forth on Schedule  3.10 is a true and complete list of all
permits, licenses,  franchises,  authorizations and approvals (none of which has
been  modified or rescinded  and all of which are in full force and effect) from
all Governmental  Entities held by the Company and the Company Subsidiaries (the
"Company  Permits").  The Company Permits  constitute all permits,  licenses and
approvals of all Governmental  Entities which are necessary for the operation of
the  businesses  of the  Company  and  the  Company  Subsidiaries  as  presently
conducted  and for the Company and the Company  Subsidiaries  to own,  lease and
operate their respective  properties,  except where the failure to have any such
permits,  licenses or approvals would not have a Material  Adverse Effect on the
Company.  The Company and the Company  Subsidiaries  are in compliance  with the
terms of the Company  Permits and all  applicable  statutes,  laws,  ordinances,
rules and  regulations,  except  where the failure so to comply would not have a
Material Adverse Effect on the Company.

         SECTION 3.11. Unlawful Payments.

                  None of the Company,  any Company Subsidiary,  or any officer,
director,  employee,  agent or  representative  of the  Company  or any  Company
Subsidiary  has made,  directly or  indirectly,  any bribe or kickback,  illegal
political  contribution,  payment  from  corporate  funds which was  incorrectly
recorded  on the books and  records of the  Company or any  Company  Subsidiary,
unlawful payment from corporate funds to governmental or municipal  officials in
their  individual  capacities  for the purpose of affecting  their action or the
actions of the jurisdiction  which they represent to obtain favorable  treatment
in securing  business or licenses or to obtain  special  concessions of any kind
whatsoever,  or illegal  payment  from  corporate  funds to obtain or retain any
business.

         SECTION 3.12. Taxes.

                  The Company and the Company  Subsidiaries  have  prepared  and
filed on a timely basis with all appropriate  Governmental Entities all material
returns,  reports,  information statements and other documentation in respect of
Taxes  that  they are  required  to  file,  including  extensions,  and all such
returns, reports, information statements and other documentation are correct and
complete in all material respects. The Company and the Company Subsidiaries have
paid in full all Taxes due (other than Taxes,  the failure of which to pay would
not have a Material  Adverse Effect on the Company) and, in the case of material
Taxes  accruing but not due,  the Company has made  adequate  provisions  in its
books and records and financial  statements for such  payments.  The Company and
the Company  Subsidiaries  have  withheld  from  payments made to its present or
former employees,  contractors,  officers and directors, creditor or other third
party, all amounts required by law to be withheld except where the liability for
which would not have a Material  Adverse  Effect on the Company,  and has, where
required, remitted such amounts within the applicable periods to the appropriate
Governmental  Entities. In addition,  (a) there are no assessments of, or claims
against,  the Company or the Company  Subsidiaries  with  respect to Taxes,  the
liability for which would have a Material  Adverse  Effect on the Company,  that
are  outstanding;  (b) no  Governmental  Entity is conducting an  examination or
audit of the Company or any Company  Subsidiary  in respect of Taxes and neither
the  Company  nor  any  Company  Subsidiary  has  received  notice  of any  such
examination or audit from any Governmental  Entity;  and (c) neither the Company
nor any Company  Subsidiary  has executed or filed any  agreement  extending the
period of assessment or collection of any Taxes which remain in effect.

         SECTION 3.13. Intellectual Property.

                  (a) Schedule 3.13 sets forth a list and brief  description  of
all  Intellectual  Property  owned,  utilized or licensed by the Company and the
Company Subsidiaries (all of the foregoing items collectively referred to as the
"Company   Intellectual   Property").   Schedule  3.13  identifies  the  Company
Intellectual Property based on the following categories: (i) inventions, patents
and patent applications, (ii) trademarks and trade names, (iii) copyrights, (iv)
licenses and (v) other Intellectual Property. The Company has furnished Acquiror
with  copies of all  license  agreements  to which the  Company  or any  Company
Subsidiary  is a party,  either as licensor  or  licensee,  with  respect to the
Company  Intellectual  Property.  The Company and the Company  Subsidiaries have
good title to or, to the  knowledge of the Company  after due  investigation  in
accordance with prudent  business  practices for a company engaged in a business
similar to that of the Company ("Due Investigation"),  the right to use, all the
Company Intellectual Property and all inventions,  processes, designs, formulae,
trade secrets and know-how  necessary  for the conduct of the  businesses of the
Company  and the Company  Subsidiaries,  as  presently  conducted  or  currently
proposed to be conducted,  without the payment of any royalty or similar payment
except to the extent disclosed on Schedule 3.13. To the knowledge of the Company
after Due Investigation,  none of the Company or any of the Company Subsidiaries
is infringing on any Intellectual  Property right of others, or has knowledge of
any  infringement  by others of such rights of the Company or any of the Company
Subsidiaries.

                  (b) All  licenses  set  forth on  Schedule  3.13 are valid and
binding  obligations of the Company or one or more of the Company  Subsidiaries,
as the case may be, and to the  knowledge of the Company,  of the other  parties
thereto,  and  enforceable  against  the  Company or one or more of the  Company
Subsidiaries, as the case may be, and to the knowledge of the Company, the other
parties thereto in accordance with their respective  terms.  Except as set forth
on Schedule 3.13, the Company and the Company  Subsidiaries  own and possess all
right,  title and  interest  in and to, or have the right to use  pursuant  to a
valid license, all the Company Intellectual Property necessary for the operation
of the  business  of the  Company  and the  Company  Subsidiaries  as  presently
conducted or currently proposed to be conducted.

                  (c) All personnel,  including employees,  agents, consultants,
and  contractors,  who have contributed to or participated in the conception and
development  of any Company  Intellectual  Property have executed  nondisclosure
agreements and either (i) have been or are party to a written agreement with the
Company or one or more of the Company Subsidiaries that has accorded the Company
and such Company Subsidiaries full, effective,  exclusive and original ownership
of all  Company  Intellectual  Property  used or required by the Company and the
Company Subsidiaries in the Company's and the Company Subsidiaries' business, or
(ii) have executed appropriate instruments of assignment in favor of the Company
or one or more of the Company  Subsidiaries  as assignees  that have conveyed to
the  Company  and such  Company  Subsidiaries  full,  effective,  and  exclusive
ownership of all Company Intellectual Property.

                  (d) The Company  also has  delivered  to Acquiror  correct and
complete  samples  or copies of all  trademarks,  service  marks,  trade  names,
copyrights,   patents,   registrations   and,   as  relate  to  the   foregoing,
applications,  licenses, agreements and permissions (as amended to date) held by
the Company and the Company  Subsidiaries,  and have made  available to Acquiror
correct  and  complete  copies of all  other  written  documentation  evidencing
ownership and  prosecution  (if  applicable) of each such item.  With respect to
each item of Company  Intellectual  Property  necessary  for the  conduct of the
business  of the  Company  and the Company  Subsidiaries  as  heretofore  and as
currently  conducted,  each as set forth on Schedule  3.13:  (i) with respect to
each item of Company  Intellectual  Property  not owned by the  Company,  to the
knowledge of the Company after Due  Investigation,  the identified owner of such
item possesses all right,  title, and interest in and to the item; (ii) the item
is not subject to any outstanding judgments,  decrees,  injunctions or orders of
any Governmental Entity or arbitrator; (iii) no charge, complaint, action, suit,
proceeding,  hearing,  investigation,  claim,  or demand is  pending  or, to the
knowledge of the Company after Due Investigation, is threatened which challenges
the legality, validity, enforceability,  use, or ownership of the item; and (iv)
except as set forth on Schedule 3.13, neither the Company nor any of the Company
Subsidiaries has agreed to indemnify any Person for or against any interference,
infringement, misappropriation, or other conflict with respect to the item.

                  (e) Except as set forth on Schedule  3.13, all of the computer
software,  computer  firmware,  computer  hardware  (whether  general or special
purpose), and other similar or related items of automated,  computerized, and/or
software  system(s)  that are used or relied on by the  Company  or any  Company
Subsidiary in the administration and conduct of their respective  businesses (i)
will be able to process date data (including,  but not limited to,  calculating,
comparing,  and  sequencing) in a consistent  manner from,  into and between the
twentieth  century (through 1999),  the year 2000 and the twenty-first  century,
including  leap  year  calculations,  and (ii)  will not  malfunction,  cease to
function, generate incorrect data, or produce incorrect results when processing,
providing, and/or receiving (A) date-related data into and between the twentieth
and twenty-first  centuries,  and (B)  date-related  data in connection with any
valid date in the twentieth and twenty-first centuries.

         SECTION 3.14. Material Contracts.

                  (a) Schedule  3.14 sets forth a complete and correct  list, as
of the date of this Agreement,  of all agreements of the following type to which
the Company or a Company  Subsidiary  is a party or may be bound  (collectively,
the "Company  Material  Contracts"):  (i) agreements  filed as an exhibit to the
Company SEC  Reports  which  remain in full force and effect and each  agreement
that would have been  required  to be filed as an  exhibit  to the  Company  SEC
Reports if such  agreement had been entered into as of the date of filing of any
such Company SEC Report; (ii) employment, severance, termination, consulting and
retirement  agreements;  (iii) loan agreements,  indentures,  letters of credit,
mortgages,  notes  and  other  debt  instruments  and  guarantees  of any of the
foregoing;  (iv) agreements that require  aggregate annual payments of more than
Fifty Thousand Dollars  ($50,000)(unless  such agreements are terminable without
penalty upon ninety (90) days (or less) notice);  (v) agreements  containing any
provisions  with  respect to a "change in  control";  (vi)  agreements  with any
employee,  director, officer or beneficial owner (as determined pursuant to Rule
13d-3  promulgated  under  the  Exchange  Act) of five  percent  (5%) or more of
Company Common Stock; (vii) agreements or arrangements  concerning a partnership
or joint venture; (viii) agreements or arrangements requiring confidentiality of
the Company except to the extent that such  agreements or  arrangements  are not
material  and have been in effect for at least five (5) years;  (ix)  agreements
and  arrangements  requiring  noncompetition  by  the  Company;  (x)  agreements
relating to the manufacturing, packaging, marketing, sale or distribution by the
Company or any  Company  Subsidiary  of any  products  owned or  licensed by the
Company or any Company  Subsidiary;  (xi) all leases (or subleases) with respect
to real property  leased by the Company as lessee or sublessee  ("Real  Property
Leases");  and (xii)  agreements  for a remaining term of five (5) years or more
with any customer of the Company or any Company Subsidiary.

                  (b)  Except as set forth in  Schedule  3.14,  all the  Company
Material  Contracts  are valid and in full force and  effect on the date  hereof
except to the  extent  they have  previously  expired in  accordance  with their
terms,  and  neither the  Company  nor any  Company  Subsidiary  has (or has any
knowledge that any party thereto has) violated any provision of, or committed or
failed to perform  any act which with or without  notice,  lapse of time or both
would  constitute  a default  under the  provisions  of,  any  Company  Material
Contract,  except for defaults  which would not reasonably be expected to have a
Material Adverse Effect on the Company.  True and complete copies of all Company
Material Contracts have been delivered to Acquiror.

         SECTION 3.15. Employee Benefit Plans.

                  (a)  Schedule  3.15 sets  forth a list of all of the  pension,
retirement, profit-sharing,  deferred compensation, stock option, employee stock
ownership,  severance  pay,  vacation  or  bonus  plans or  agreements  or other
incentive  plans or agreements,  all other employee  programs,  arrangements  or
agreements  and all  other  employee  benefit  plans or  fringe  benefit  plans,
including,  without  limitation,  all "employee  benefit  plans" as that term is
defined in Section 3(3) of the Employee  Retirement Income Security Act of 1974,
as  amended  ("ERISA")  (collectively,   "Benefit  Plans"),  currently  adopted,
maintained  by,  sponsored  in  whole or in part by,  or  contributed  to by the
Company or any entity  required to be  aggregated  with the  Company  which is a
member of the  "controlled  group of  corporations"  which  includes the Company
within  the  meaning  of  Section  414(b) or (c) of the Code  (each,  a "Company
Commonly  Controlled Entity") for the benefit of present and former employees or
directors of the Company and of each Company Subsidiary or their  beneficiaries,
or  providing  benefits to such  persons in respect of services  provided to any
such entity  (collectively,  the "Company Benefit  Plans").  Any Company Benefit
Plan which is an "employee  pension  benefit  plan",  as that term is defined in
Section 3(2) of ERISA, is referred to herein as a "Company ERISA Plan".

                  (b)  Each  of  the  Company   Benefit  Plans  intended  to  be
"qualified" within the meaning of Section 401(a) of the Code has been determined
by the Internal  Revenue Service to be so qualified and no  circumstances  exist
that could  reasonably be expected by the Company to result in the revocation of
any such determination.  Each of the Company Benefit Plans is in compliance with
the applicable  terms of ERISA and the Code and any other applicable laws, rules
and  regulations,  the breach or  violation  of which could result in a Material
Adverse Effect to the Company or any Company Commonly Controlled Entity.

                  (c) No Company ERISA Plan which is a defined  benefit  pension
plan has any "unfunded  current  liability",  as that term is defined in Section
302(d)(8)(A)  of ERISA,  and the present  fair market value of the assets of any
such plan equals or exceeds the plan's  "benefit  liabilities",  as that term is
defined in Section 4001(a)(16) of ERISA, when determined under actuarial factors
that would apply if the plan terminated in accordance with all applicable  legal
requirements.

                  (d) No  Company  Benefit  Plan is or has been a  multiemployer
plan  within the  meaning of Section  3(37) of ERISA (a  "Multiemployer  Plan").
Neither the Company nor any Company Commonly Controlled Entity has completely or
partially withdrawn from any Multiemployer Plan. No termination liability to the
Pension   Benefit   Guaranty   Corporation   or  withdrawal   liability  to  any
Multiemployer  Plan that is material in the  aggregate has been or is reasonably
expected to be incurred with respect to any Multiemployer Plan by the Company or
any Company Commonly Controlled Entity.

                  (e) The Company has furnished to Acquiror  complete copies, as
of the date hereof,  of all of the Company  Benefit Plans that have been reduced
to writing, together with all documents establishing or constituting any related
trust,  annuity contract,  insurance contract or other funding  instrument,  and
copies of all "employee  benefit  plans" as that term is defined in Section 3(3)
of ERISA,  including  a summary  of such  plans  that have not been  reduced  to
writing.  The Company has furnished to Acquiror  complete copies of all existing
current plan summaries,  employee booklets, personnel manuals and other material
documents or written materials concerning the Company Benefit Plans.

                  (f) Except as set forth in  Schedule  3.15(f),  no amount that
could be received  by (whether in cash or property or the vesting of  property),
or benefit provided to, any officer,  director or employee of the Company or any
of its Affiliates who is a "disqualified individual" (as such term is defined in
proposed Treasury  Regulation Section 1.280G-1) under any employment,  severance
or  termination  agreement,  other  compensation  arrangement  or  Benefit  Plan
currently  in effect  would be an "excess  parachute  payment"  (as such term is
defined in Section  280G(b)(1)  of the  Code).  Except as set forth in  Schedule
3.15(f),  no such Person is entitled to receive any additional  payment from the
Company,  the Surviving  Corporation or any other Person (a "Parachute  Gross Up
Payment")  in the event that the  excise  tax of Section  4999(a) of the Code is
imposed on such Person.  Except as set forth in Schedule  3.15(f),  the Board of
Directors of the Company has not granted to any officer, director or employee of
the Company or any Company  Subsidiary any right to receive any Parachute  Gross
Up  Payment.  Schedule  3.15(f)  sets forth the "base  amount"  (as such term is
defined  in Section  280G(b)(3)  of the Code) for each  disqualified  individual
(defined as set forth above) whose  Options will vest pursuant to their terms in
connection with this Agreement or the Merger.

                  (g) All required reports and  descriptions,  if any (including
Form 5500 Annual  Reports,  Summary  Annual  Reports,  PBGC 1's and Summary Plan
Descriptions) have been filed or distributed  appropriately with respect to each
Company  Benefit Plan.  The  requirements  of Part 6 of Subtitle B of Title I of
ERISA and of  Section  4980B of the Code  ("COBRA"),  and the  Health  Insurance
Portability and  Accountability Act of 1996 ("HIPAA") have been met with respect
to each Company Benefit Plan.

                  (h) No Company Benefit Plan is an ESOP or otherwise invests in
"employer securities" (as such term is defined in Section 409(l) of the Code).

                  (i) The Company has made all  contributions and other payments
required by and due under the terms of each  Company  Benefit Plan and has taken
no action (including,  without limitation,  actions required by law) relating to
any Company  Benefit Plan that will  increase  Acquiror's,  the Company's or any
Company Commonly Controlled Entity's obligation under any Company Benefit Plan.

                  (j) No Company Benefit Plan is a "qualified  foreign plan" (as
such term is defined in Section 404A of the Code),  and no Company  Benefit Plan
is subject  to the laws of any  jurisdiction  other  than the  United  States of
America or one of its political subdivisions.

                  (k)   No   Company   Benefit   Plan   promises   or   provides
post-retirement  medical  life  insurance  or other  benefits  due now or in the
future to  current,  former or retired  employees  of the Company or any Company
Common Controlled Entity other than benefits required pursuant to COBRA.

                  (l) No  "pension  plans",  as such term is  defined in Section
3(2) of  ERISA,  maintained  by the  Company  or a Company  Commonly  Controlled
Entity, have been frozen or terminated in the last three (3) calendar years.

         SECTION 3.16. Properties; Assets.

                  Neither the Company nor any of the Company  Subsidiaries  owns
(of record or  beneficially)  any real  property or has any interest in any real
property  other  than  the  leasehold  interests  granted  pursuant  to the Real
Property Leases. The Company or one of the Company Subsidiaries is the lessee of
all  leasehold  estates  granted  pursuant to the Real  Estate  Leases and is in
possession of the properties  purported to be leased  thereunder,  and each such
Real Property  Lease is valid  without  default  thereunder  by the lessee.  The
assets and  properties of the Company and the Company  Subsidiaries,  taken as a
whole,  are in good  operating  condition  and  repair  (ordinary  wear and tear
excepted),  and constitute  all of the assets and properties  which are required
for the businesses and operations of the Company and the Company Subsidiaries as
presently conducted.

         SECTION 3.17. Labor Relations.

                  Neither the Company nor any Company  Subsidiary  is a party to
any  collective  bargaining  agreement or other  contract or agreement  with any
labor  organization  or  other  representative  of any of the  employees  of the
Company or any Company Subsidiary. The Company and each Company Subsidiary is in
compliance in all material  respects with all laws relating to the employment or
the workplace,  including,  without  limitation,  provisions  relating to wages,
hours,  collective  bargaining,  safety and health,  work  authorization,  equal
employment   opportunity,   affirmative   action  plans,   immigration  and  the
withholding of income taxes, unemployment  compensation,  worker's compensation,
employee privacy and right to know and social security contributions.

         SECTION 3.18.     Environmental Matters.

                  (a) Except for matters which would not have a Material Adverse
Effect on the Company,  (i) the Company,  each  Company  Subsidiary  and, to the
knowledge  of the  Company,  each  Product  Licensee is in  compliance  with all
applicable  Environmental Laws (as defined below); (ii) none of the Company, any
Company Subsidiary or, to the knowledge of the Company, any Product Licensee has
received any written  communication  that alleges that the Company,  any Company
Subsidiary  or  any  Product  Licensee  is  not in  compliance  with  applicable
Environmental  Laws;  (iii) all  permits and other  governmental  authorizations
currently held by the Company,  each Company Subsidiary and, to the knowledge of
the Company,  each Product Licensee pursuant to the Environmental Laws ("Company
Environmental  Permits") are in full force and effect, the Company, each Company
Subsidiary  and, to the  knowledge of the Company,  each Product  Licensee is in
compliance with all of the terms of such Company  Environmental  Permits, and no
other permits or other governmental  authorizations are required by the Company,
any  Company  Subsidiary  or,  to the  knowledge  of the  Company,  any  Product
Licensee,  for  the  conduct  of  their  respective  businesses;  and  (iv)  the
management,  handling, storage,  transportation,  treatment, and disposal by the
Company,  each Company  Subsidiary  and, to the  knowledge of the Company,  each
Product  Licensee of any Hazardous  Materials (as defined below) is and has been
in compliance with all applicable Environmental Laws.

                  (b) There is no Company Environmental Claim (as defined below)
pending or, to the knowledge of the Company, threatened against or involving the
Company,  any of the Company  Subsidiaries or against any Person whose liability
for any Environmental  Claim the Company or any of the Company  Subsidiaries has
or may have retained or assumed either contractually or by operation of law.

                  (c) Except for matters which would not have a Material Adverse
Effect on the Company,  to the  knowledge  of the Company,  there are no past or
present  actions or  activities  by the Company,  any Company  Subsidiary or any
other Person involving the storage,  treatment,  release,  emission,  discharge,
disposal or  arrangement  for disposal of any  Hazardous  Materials,  that could
reasonably form the basis of any Company Environmental Claim against the Company
or any Company  Subsidiary or against any Person whose liability for any Company
Environmental  Claim the Company or any Company  Subsidiary may have retained or
assumed either contractually or by operation of law.

                  (d) As used  herein,  these  terms  shall  have the  following
meanings:

                   (i)   "Company   Environmental   Claim"  means  any  and  all
         administrative,  regulatory or judicial actions, suits, demands, demand
         letters,  directives,  claims,  liens,  investigations,  proceedings or
         notices of noncompliance  or violation  (written or oral) by any Person
         or Governmental  Entity alleging  potential  liability  arising out of,
         based on or  resulting  from the  presence,  or release  or  threatened
         release into the  environment  of, or any  exposure  to, any  Hazardous
         Materials at any  property or location  owned or leased by the Company,
         any Company  Subsidiary or any Product Licensee or other  circumstances
         forming  the  basis  of  any  violation  or  alleged  violation  of any
         Environmental Law.

                   (ii)  "Environmental  Laws"  means  all  applicable  foreign,
         federal,  state and local  laws  (including  the  common  law),  rules,
         requirements  and  regulations  relating to pollution,  the environment
         (including,   without   limitation,   ambient   air,   surface   water,
         groundwater,  land surface or subsurface strata) or protection of human
         health as it relates to the environment including,  without limitation,
         laws and regulations  relating to releases of Hazardous  Materials,  or
         otherwise relating to the manufacture,  processing,  distribution, use,
         treatment,  storage,  disposal,  transport  or  handling  of  Hazardous
         Materials or relating to management of asbestos in buildings.

                   (iii)  "Hazardous  Materials"  means wastes,  substances,  or
         materials (whether solids, liquids or gases) that are deemed hazardous,
         toxic,  pollutants,  or  contaminants  under  any  Environmental  Laws,
         including,   without  limitation,   substances  defined  as  "hazardous
         substances",  "toxic  substances",  "radioactive  materials,  including
         sources of ionizing and nonionizing radiation",  "petroleum products or
         wastes"  or other  similar  designations  in, or  otherwise  subject to
         regulation under, any Environmental Law.

         SECTION 3.19. Insurance.

                  Schedule  3.19  contains a list of all  insurance  policies of
director and officer liability,  title,  property,  fire,  casualty,  liability,
life, workmen's compensation, libel and slander, and other forms of insurance in
force  with  respect  to the  Company  and the  Company  Subsidiaries.  All such
insurance  policies:  (a) insure against such risks, and are in such amounts, as
are  appropriate  and  reasonable,  in the  judgment of the  Company's  Board of
Directors,  considering  the Company and the Company  Subsidiaries'  properties,
businesses and operations;  (b) are in full force and effect; and (c) are valid,
outstanding,  and  enforceable.  Neither  the  Company  nor  any of the  Company
Subsidiaries  has received or given notice of  cancellation  with respect to any
such insurance policies.

         SECTION 3.20. Board Approval; Vote Required.

                  The Board of Directors of the Company has determined  that the
transactions  contemplated  by this  Agreement  and  the  Option  Agreement  are
advisable and in the best interests of the Company and its  stockholders and has
resolved  to  recommend  to such  stockholders  that  they vote in favor of this
Agreement.  The  affirmative  vote at the  Company  Stockholders  Meeting of the
holders of a majority of all outstanding shares of Company Common Stock to adopt
this  Agreement  is the only vote of the  holders  of any class or series of the
Company's  capital stock  necessary to approve and adopt this  Agreement and the
transactions contemplated hereby, including the Merger.

         SECTION 3.21. Opinion of Financial Advisor.

                  The Board of Directors of the Company has received the written
opinion of  Hambrecht & Quist LLC, the  Company's  financial  advisor,  that the
Merger  Consideration to be received by the Company's  stockholders  pursuant to
this  Agreement is fair from a financial  point of view to the holders of shares
of Company  Common Stock. A copy of such opinion has been delivered to Acquiror,
and such opinion has not been withdrawn or modified in any material respect.

         SECTION 3.22. Brokers.

                  Except  for  Hambrecht  & Quist  LLC,  no  broker,  finder  or
investment  banker  is  entitled  to any  brokerage,  finder's  or other  fee or
commission in connection  with the  transactions  contemplated by this Agreement
and the Option  Agreement  based upon  arrangements  made by or on behalf of the
Company.  Prior to the date of this  Agreement,  the  Company  has  provided  to
Acquiror a complete and correct copy of all  agreements  between the Company and
Hambrecht  & Quist LLC  pursuant  to which  such firm  will be  entitled  to any
payment  relating to the  transactions  contemplated  by this  Agreement and the
Option Agreement.

         SECTION 3.23. Takeover Provisions Inapplicable.

                  Prior to the date of this Agreement, the Board of Directors of
the  Company  has taken all  requisite  action to cause this  Agreement  and the
transactions contemplated by this Agreement (including those contemplated by the
Option  Agreement)  to be exempt from Section 203 of the Delaware  Law. No other
state takeover  statute or similar statute or regulation  applies to or purports
to apply to this  Agreement,  the  Option  Agreement,  the  Merger  or the other
transactions contemplated by this Agreement or the Option Agreement.

         SECTION 3.24. Pooling; Tax Matters.

                  Neither  the Company  nor any of its  Affiliates  has taken or
agreed to take any action or failed to take any action  that would  prevent  the
Merger from (a) being treated for financial accounting purposes as a "pooling of
interests" in accordance with GAAP and the regulations  and  interpretations  of
the SEC,  or (b)  constituting  a  reorganization  within the meaning of Section
368(a) of the Code.

         SECTION 3.25. Registration Statement; Proxy Statement/Prospectus.

                  The  information  supplied  by the  Company or  required to be
supplied  by the  Company  (except  to  the  extent  revised  or  superseded  by
amendments or supplements) for inclusion in the  registration  statement on Form
S-4, or any  amendment or  supplement  thereto,  pursuant to which the shares of
Acquiror  Common Stock to be issued in the Merger will be  registered  under the
Securities  Act  (including any  amendments or  supplements,  the  "Registration
Statement")  shall not, at the time the  Registration  Statement  (including any
amendments or supplements thereto) is declared effective by the SEC, contain any
untrue  statement of a material fact or omit to state any material fact required
to be stated  therein or necessary in order to make the statements  therein,  in
light of the  circumstances  under  which they were made,  not  misleading.  The
information  supplied  by the  Company or required to be supplied by the Company
(except to the extent  revised or superseded by amendments or  supplements)  for
inclusion in the proxy statement relating to the Company  Stockholders  Meeting,
such proxy  statement,  together with the  prospectus  relating to the shares of
Acquiror  Common  Stock to be issued in the  Merger,  in each case as amended or
supplemented from time to time, the "Proxy  Statement/Prospectus") shall not, on
the  date  the  Proxy  Statement/Prospectus  is first  mailed  to the  Company's
stockholders,  at  the  time  of the  Company  Stockholders  Meeting  and at the
Effective  Time,  contain  any  statement  which,  at such  time,  is  false  or
misleading with respect to any material fact, or omit to state any material fact
necessary  in  order  to make  the  statements  made  therein,  in  light of the
circumstances  under which they are made,  not false or  misleading,  or omit to
state any  material  fact  necessary  to correct  any  statement  in any earlier
communication with respect to the solicitation of proxies by or on behalf of the
Company  for  the  Company  Stockholders  Meeting  which  has  become  false  or
misleading.  The Proxy Statement/Prospectus will comply in all material respects
with the  provisions of the Exchange Act.  Notwithstanding  the  foregoing,  the
Company  makes no  representation,  warranty  or  covenant  with  respect to any
information  supplied or required to be supplied by Acquiror  which is contained
in or omitted from any of the foregoing documents.

         SECTION 3.26. Rights Agreement.

                  The  Company  has taken  all  actions  necessary  to cause the
Rights Agreement to be amended to (a) render the Rights  Agreement  inapplicable
to this Agreement,  the Option Agreement,  the Merger and the other transactions
contemplated by this Agreement and the Option Agreement, and (b) ensure that (i)
none of Acquiror,  Merger Sub or any other  Acquiror  Subsidiary is an Acquiring
Person (as defined in the Rights  Agreement)  pursuant  to the Rights  Agreement
solely by virtue of the execution of this Agreement and the Option  Agreement or
the  consummation of the Merger or the other  transactions  contemplated by this
Agreement and the Option  Agreement and (ii) a  Distribution  Date, a Triggering
Event or a Share  Acquisition  Date (as such  terms are  defined  in the  Rights
Agreement)  does not occur by reason of the execution of this  Agreement and the
Option  Agreement,  the  consummation  of the Merger or the  consummation of the
other transactions contemplated by this Agreement and the Option Agreement.

         SECTION 3.27. Regulatory Compliance.

                  (a) As to each product subject to the  jurisdiction of the FDA
under the Federal  Food,  Drug and Cosmetic Act and the  regulations  thereunder
("FDCA")  and the  Public  Health  Services  Act  ("PHSA")  and the  regulations
thereunder, and each product subject to the jurisdiction of the Drug Enforcement
Administration  ("DEA")  under the  Controlled  Substances  Act  ("CSA") and the
regulations  thereunder (each such product, a "Pharmaceutical  Product") that is
manufactured,  packaged, labeled, tested, distributed,  sold, and/or marketed by
the Company or any Company Subsidiary, or any Pharmaceutical Product licensed by
the Company to any licensee of the Company or any Company Subsidiary (a "Product
Licensee"),  such  Pharmaceutical  Product  is  being  manufactured,   packaged,
labeled, tested,  distributed,  sold and/or marketed by the Company, any Company
Subsidiary,  and, to the knowledge of the Company after Due Investigation,  each
Product  Licensee in compliance  with all  applicable  requirements  under FDCA,
PHSA, CSA, and similar laws, rules and regulations  relating to  investigational
use, premarket clearance, licensure, or application approval, good manufacturing
practices,  good  laboratory  practices,  good  clinical  practices,   labeling,
advertising,  record  keeping,  filing of reports  including  but not limited to
adverse event reports as required by 21 C.F.R. sec. 314.80, and security, except
where the failure to be in compliance  would not have a Material  Adverse Effect
on the Company. None of the Company, any Company Subsidiary or, to the knowledge
of the Company after Due  Investigation,  any Product  Licensee has received any
notice or other  communication  from the FDA,  DEA,  or any  other  Governmental
Entity (i)  contesting  the premarket  clearance,  licensure,  registration,  or
approval of, the uses of, the  distribution  of, the  manufacturing or packaging
of, the testing of, sale of, controlled substance scheduling of, or the labeling
and promotion of any  Pharmaceutical  Product  described in this Section 3.27 or
(ii) otherwise  alleging any violation of any laws,  rules or regulations by the
Company,  any  Company  Subsidiary  or any Product  Licensee  which would have a
Material Adverse Effect on the Company.

                  (b) No  Pharmaceutical  Products of the Company or any Company
Subsidiary or  Pharmaceutical  Products which are licensed by the Company to any
Product  Licensee  have  been  recalled,   withdrawn,   replaced,  suspended  or
discontinued nor have any DEA registrations been terminated by the Company,  any
Company  Subsidiary or any Product  Licensee in the United States or outside the
United States (whether  voluntarily or otherwise)  since January 1, 1995.  There
are no  completed or pending  efforts to impose a clinical  hold on any clinical
investigation,   proceedings  seeking  the  recall,   withdrawal,   replacement,
suspension or seizure of any such Pharmaceutical Product, or proceedings seeking
the suspension or revocation of any DEA registration  including an order to show
cause against the Company,  any Company  Subsidiary  or, to the knowledge of the
Company after Due Investigation, any Product Licensee, nor have any such efforts
or proceedings been pending at any time since January 1, 1995 which would have a
Material Adverse Effect on the Company.

                  (c) As to each biological drug or other drug of the Company or
the  Company   Subsidiaries   for  which  a   biological   license   application
establishment  license  application,   product  license  application,  new  drug
application,   investigational  new  drug  application,   abbreviated  new  drug
application,  registration  issued  by the DEA,  or  similar  state  or  foreign
regulatory  application has been approved, the Company, the Company Subsidiaries
and,  to the  knowledge  of the  Company  after Due  Investigation,  the Product
Licensees are in compliance with 21 U.S.C.  sec. 355, 42 U.S.C. sec. 351, and 21
U.S.C.  sec.  822,  and 21  C.F.R.  Parts  312,  314,  601,  and  1301 et  seq.,
respectively,   and  similar  laws  and  all  terms  and   conditions   of  such
applications,  except  where the  failure to be in  compliance  would not have a
Material Adverse Effect on the Company. As to each such biological drug or other
drug, the Company and any relevant  Company  Subsidiary and, to the knowledge of
the  Company  after  Due  Investigation,  Product  Licensee,  and the  officers,
employees  or  agents  of the  Company,  such  Company  Subsidiary  and,  to the
knowledge of the Company after Due  Investigation,  the  officers,  employees or
agents  of any  Product  Licensee  have  included  in the  application  for such
biological drug or other drug, where required, the certification described in 21
U.S.C.  sec.  335a(k)(1) or any similar law and the list  described in 21 U.S.C.
sec.  335a(k)(2) or any similar law, and such certification and such list was in
each case true and accurate when made and remained true and accurate thereafter,
except in the case where the failure of such application to be true and accurate
would not have a  Material  Adverse  Effect on the  Company.  In  addition,  the
Company, the Company Subsidiaries and, to the knowledge of the Company after Due
Investigation,  Product Licensees are in material compliance with all applicable
registration  and listing  requirements  set forth in 21 U.S.C.  sec. 360 and 21
C.F.R. Part 207 and all similar laws.

                  (d)  Each  article  of  any  biological  drug  or  other  drug
manufactured and/or distributed by the Company,  any of the Company Subsidiaries
and,  to the  knowledge  of the  Company  after Due  Investigation,  any Product
Licensee is not adulterated within the meaning of 21 U.S.C. sec. 351 (or similar
laws) or misbranded  within the meaning of 21 U.S.C. sec. 352 (or similar laws),
and is not a product that is in violation of 21 U.S.C.  sec. 355, 42 U.S.C. sec.
351 (or  similar  laws),  except  where  such  failure  in  compliance  with the
foregoing would not have a Material Adverse Effect on the Company.

                  (e) Except with respect to Lyphomed and  Lyphomed's  officers,
employees and agents,  none of the Company,  any Company  Subsidiary  or, to the
knowledge of the Company after Due Investigation,  any Product Licensee,  or any
officer,  employee or agent of either the Company, any Company Subsidiary or, to
the knowledge of the Company after Due  Investigation,  any Product Licensee has
made any untrue statement of a material fact or fraudulent  statement to the FDA
or other Governmental Entity, failed to disclose a fact required to be disclosed
to the FDA or any  other  Governmental  Entity,  or  committed  an  act,  made a
statement,  or failed to make a statement  that, at the time such disclosure was
made,  could  reasonably be expected to provide a basis for the FDA or any other
Governmental Entity to invoke its policy respecting "Fraud, Untrue Statements of
Material  Facts,  Bribery,  and Illegal  Gratuities",  set forth in 56 Fed. Reg.
46191  (September  10, 1991) or any similar  policy.  Neither the  Company,  any
Company  Subsidiary or, to the knowledge of the Company after Due Investigation,
any Product  Licensee,  or any officer,  employee or agent of the  Company,  any
Company  Subsidiary or, to the knowledge of the Company after Due Investigation,
any Product Licensee,  has been convicted of any crime or engaged in any conduct
for which debarment is mandated by 21 U.S.C.  sec. 335a(a) or any similar law or
authorized by 21 U.S.C. sec. 335a(b) or any similar law.

                  (f) None of the  Company,  any Company  Subsidiary  or, to the
knowledge  of the Company  after Due  Investigation,  any Product  Licensee  has
received any written  notice that the FDA or any other  Governmental  Entity has
commenced,  or threatened  to initiate,  any action to withdraw its approval of,
request  the recall of, or change the  controlled  substances  schedules  of any
product  of  the  Company,  any  Company  Subsidiary  or  Product  Licensee,  or
commenced,  or threatened  to initiate,  any action to impose a clinical hold on
any clinical  investigation  by the Company,  any Company  Subsidiary or Product
Licensee,  or any action to enjoin  production  at, or suspend or revoke the DEA
registration  or any  facility  of, or enter into a Consent  Decree of Permanent
Injunction with the Company,  any Company  Subsidiary or Product  Licensee which
would have a Material Adverse Effect on the Company.

                  (g) The Company,  each of the Company Subsidiaries and, to the
knowledge of the Company after due investigation,  the Product Licensees are not
in violation of, in any material respect,  and are in material  compliance with,
all applicable laws, rules and regulations regarding the conduct of pre-clinical
and  clinical  investigations,  including,  but not limited to, good  laboratory
practices,  good clinical  practices,  investigational new drug requirements and
requirements regarding informed consent and Institutional Review Boards designed
to ensure the protection of the rights and welfare of human subjects, including,
but not limited to, the requirements  provided in 21 C.F.R. Parts 50, 56, 58 and
312.

                  (h) To the extent that any  biological  drugs or other drug is
intended for export from the United  States,  each of the  Company,  any Company
Subsidiary  and, to the knowledge of the Company after Due  Investigation,  each
Product Licensee is in full compliance with all of the requirements in 21 U.S.C.
sec. 381(e) or sec. 382, and the Controlled Substances Import and Export Act (21
U.S.C. sec. 951, et. seq.

                  (i) The Company and each of the Company  Subsidiaries  and, to
the knowledge of the Company after Due Investigation,  Product Licensees are not
in violation of and are in material  compliance with all applicable  laws, rules
and  regulations   regarding  the   manufacture,   analysis,   distribution  and
investigation  of  controlled  substances  including,  but not  limited  to, the
requirements  provided by 21 U.S.C.  sec. 801, et. seq., and 21 C.F.R. sec. 1300
et. seq.

                  (j) The Company has provided or made available to Acquiror all
documents in its possession,  the possession of the Company  Subsidiaries or, to
the knowledge of the Company after Due Investigation,  the possession of Product
Licensees concerning  communication to or from FDA or DEA, or prepared by FDA or
DEA which bear in any material  respect on compliance with FDA or DEA regulatory
requirements.

         SECTION 3.28. Current Cash Reserves; Indebtedness.

                  As of the date of this Agreement,  the aggregate amount of (i)
the Company's cash on hand,  plus (ii) liquid  investments of the Company with a
maturity of three years or less ((i) and (ii)  "Current  Cash  Reserves")  is at
least  Sixty Four  Million  Dollars  ($64,000,000).  The  Company  owns all such
Current Cash Reserves free and clear of all Encumbrances, except as set forth in
Schedule  3.28.  As  of  the  date  of  this  Agreement,   the  Company  has  no
Indebtedness.

         SECTION 3.29. Transaction Expenses.

                  As of the date of this  Agreement,  the  aggregate  good faith
estimate of the Transaction Expenses to be incurred by the Company in connection
with the Merger are as set forth on Schedule 3.29.

         SECTION 3.30. Disclosure.

                  No representation or warranty of the Company in this Agreement
and no statement in the Company's  disclosure  schedules  contains any statement
which is false or misleading with respect to any material fact or omits to state
a material fact necessary to make the statements herein or therein,  in light of
the circumstances in which they were made, not false or misleading.

                                   ARTICLE IV

                  REPRESENTATIONS AND WARRANTIES OF MERGER SUB

                  Acquiror and Merger Sub jointly and  severally  represent  and
warrant to the Company as follows:

         SECTION 4.1. Organization and Qualification.

                  Merger Sub is a corporation  duly organized,  validly existing
and in good standing  under  Delaware Law.  Merger Sub was formed solely for the
purpose of engaging in the  transactions  contemplated by this Agreement.  As of
the date of this Agreement,  except for  obligations or liabilities  incurred in
connection with its  incorporation  and organization and otherwise in connection
with  the  transactions  contemplated  by  this  Agreement,  Merger  Sub has not
incurred,  directly or indirectly,  any obligations or liabilities or engaged in
any  business  activities  of any type or kind  whatsoever  or entered  into any
agreements or arrangements with any Person.

         SECTION 4.2. Certificate of Incorporation and Bylaws.

                  Merger Sub has  heretofore  made  available  to the  Company a
complete and correct copy of the certificate of incorporation  and the bylaws of
Merger Sub,  each as amended to date.  Such  certificate  of  incorporation  and
bylaws are in full force and effect.  Merger Sub is not in  violation  of any of
the provisions of its certificate of incorporation or bylaws.

         SECTION 4.3. Authority.

                  Merger Sub has the necessary  corporate power and authority to
enter  into  this  Agreement,  to  perform  its  obligations  hereunder  and  to
consummate the transactions  contemplated  hereby. The execution and delivery of
this  Agreement  by  Merger  Sub  and  the  consummation  by  Merger  Sub of the
transactions  contemplated  hereby have been duly and validly  authorized by all
necessary  corporate  action and no other  corporate  proceedings on the part of
Merger Sub are  necessary  to authorize  this  Agreement  or to  consummate  the
transactions  contemplated  hereby.  This  Agreement  has been duly executed and
delivered  by Merger Sub and,  assuming  the due  authorization,  execution  and
delivery of this  Agreement by the Company and  Acquiror,  constitutes  a legal,
valid and binding  obligation of Merger Sub,  enforceable in accordance with its
terms, except as such  enforceability may be limited by bankruptcy,  insolvency,
reorganization,  moratorium  and other  similar  laws of  general  applicability
relating to or affecting  creditors'  rights generally and by the application of
general principles of equity.

         SECTION 4.4. No Conflict; Required Filings and Consents.

                  (a) The execution and delivery of this Agreement by Merger Sub
do not,  and  the  performance  by  Merger  Sub of its  obligations  under  this
Agreement   will  not,  (i)  conflict  with  or  violate  the   certificate   of
incorporation  or bylaws of Merger  Sub,  (ii)  subject to  compliance  with the
requirements  set forth in Section  4.4(b)  below,  conflict with or violate any
law, statute, ordinance, rule, regulation,  order, judgment or decree applicable
to Merger Sub or by which any of its  properties or assets is bound or affected,
or (iii)  except  as set  forth in  Schedule  5.5,  result  in any  breach of or
constitute  a default  (or an event  which with  notice or lapse of time or both
would  become a default)  under,  or give to others  any rights of  termination,
amendment,  acceleration  or  cancellation  of, or result in the creation of any
Encumbrance  on any of the  properties  or assets of Merger Sub pursuant to, any
note, bond, mortgage,  indenture,  contract,  agreement, lease, license, permit,
franchise or other instrument or obligation to which Merger Sub is a party or by
which  Merger  Sub or any of its  properties  or  assets  is bound or  affected,
except,  in the case of clauses  (ii) and (iii) above,  for any such  conflicts,
violations,  breaches,  defaults or other  alterations or occurrences that would
not prevent or delay  consummation  of the Merger in any  material  respect,  or
otherwise  prevent  Merger  Sub  from  performing  its  obligations  under  this
Agreement in any material respect.

                  (b) The execution and delivery of this Agreement by Merger Sub
does not, and the performance of this Agreement by Merger Sub will not,  require
any  consent,   approval,   authorization  or  permit  of,  or  filing  with  or
notification  to,  any  Governmental  Entity,  except  (i)  for  (A)  applicable
requirements,  if any, of the Exchange Act, Securities Act, state takeover laws,
the National  Association of Securities Dealers,  Inc. (the "NASD"), the HSR Act
and the FDA, (B) applicable  requirements,  if any, of the consents,  approvals,
authorizations  or  permits  described  in  Schedule  5.5,  and (C)  filing  and
recordation  of  appropriate  merger  documents as required by Delaware Law, and
(ii)  where  failure  to obtain  such  consents,  approvals,  authorizations  or
permits,  or to make such filings or  notifications,  would not prevent or delay
consummation of the Merger in any material respect.

                                    ARTICLE V

                   REPRESENTATIONS AND WARRANTIES OF ACQUIROR

                  Acquiror represents and warrants to the Company subject to the
exceptions  set forth  herein  and in  Acquiror's  disclosure  schedules  (which
exceptions  shall  specifically  identify a Section,  Subsection  or clause of a
single  Section or Subsection  hereof,  as  applicable,  to which such exception
relates, it being understood and agreed that each such exception shall be deemed
to be disclosed  both under such  Section,  Subsection  or clause hereof and any
other Section,  Subsection or clause hereof to which such disclosure  reasonably
relates) that:

         SECTION 5.1. Organization and Qualification; Subsidiaries.

                  Each of Acquiror and each  Subsidiary  of  Acquiror,  (each an
"Acquiror  Subsidiary"  and  collectively,  the  "Acquiror  Subsidiaries")  is a
corporation duly organized, validly existing and in good standing under the laws
of the jurisdiction of its organization.  Acquiror and each Acquiror  Subsidiary
is duly  qualified to conduct its  business,  and is in good  standing,  in each
jurisdiction where the character of its properties owned,  operated or leased or
the nature of its activities makes such qualification necessary, except for such
failures which would not have a Material  Adverse  Effect on Acquiror.  Acquiror
and each  Acquiror  Subsidiary  has the  requisite  power and  authority and any
necessary governmental authority,  franchise, license or permit to own, operate,
lease and otherwise to hold and operate its assets and  properties  and to carry
on its business as now being conducted, except for such failures which would not
have a Material  Adverse  Effect on Acquiror.  The Acquiror has no  Subsidiaries
other than those listed in Schedule  5.1, each of which is  wholly-owned  by the
Acquiror,  or any direct or indirect  beneficial  ownership  of any  securities,
equity or other  ownership  interest  in any Person  other than those  listed on
Schedule 5.1.

         SECTION 5.2. Certificate of Incorporation and Bylaws.

                  Acquiror  has  heretofore  delivered to the Company a complete
and correct  copy of the articles of  incorporation  and the bylaws of Acquiror,
each as amended to date. Such articles of  incorporation  and bylaws are in full
force and effect.  Acquiror is not in violation of any of the  provisions of its
articles of incorporation or bylaws.

         SECTION 5.3. Capitalization.

                  (a) The authorized  capital stock of Acquiror  consists of one
hundred  fifty million  (150,000,000)  shares of Acquiror  Common  Stock.  As of
November 12, 1999: (i) forty-eight million two hundred thirty-four  thousand two
hundred  thirty-three  (48,234,233)  shares of Acquiror Common Stock were issued
and outstanding;  (ii) four million eight hundred thousand (4,800,000) shares of
Acquiror   Common  Stock  were  reserved  for  issuance  upon  the  exercise  of
outstanding  employee  stock  options  or other  rights to  purchase  or receive
Acquiror Common Stock granted under  Acquiror's 1997 Incentive and  Nonqualified
Stock Option Plan (the "1997 Plan"); (iii) four hundred fifty thousand (450,000)
shares of Acquiror  Common Stock were reserved for issuance upon the exercise of
outstanding  stock  options or other  rights to receive  Acquiror  Common  Stock
granted under Acquiror's 1998 Non-employee Director Stock Option Plan (the "1998
Plan", and together with the 1997 Plan, the "Acquiror Stock Option Plans"),  and
(iv) no shares of Acquiror  Common  Stock were held by  Acquiror  in  Acquiror's
treasury.  Schedule 5.3 sets forth a complete and correct  list,  as of November
24, 1999,  of the number of shares of Acquiror  Common Stock subject to employee
stock  options or other  rights to purchase  or receive  Acquiror  Common  Stock
granted under the Acquiror  Stock Option Plans,  the dates of grant and exercise
prices thereof.

                  (b) All  outstanding  shares of capital stock of Acquiror are,
and all  shares  which may be issued  will be,  when  issued,  duly  authorized,
validly  issued,  fully paid and  nonassessable  and not  subject to  preemptive
rights. Except as set forth in this Section 5.3 and except for changes resulting
from the issuance of shares of Acquiror  Common  Stock  pursuant to the Acquiror
Stock Option Plans or as expressly  permitted by this  Agreement,  (i) there are
not issued, reserved for issuance or outstanding (A) any shares of capital stock
or other voting  securities of Acquiror,  (B) any  securities of Acquiror or any
Acquiror  Subsidiary  convertible into or exchangeable or exercisable for shares
of capital stock or voting  securities of or ownership  interests in Acquiror or
any Acquiror  Subsidiary,  (C) any warrants,  calls,  options or other rights to
acquire from Acquiror or any Acquiror Subsidiary, and any obligation of Acquiror
or any Acquiror  Subsidiary to issue,  any capital stock,  voting  securities or
other ownership interests in, or securities  convertible into or exchangeable or
exercisable  for  capital  stock or  voting  securities  of or  other  ownership
interests in, Acquiror or any Acquiror Subsidiary, (ii) there are no outstanding
obligations  of Acquiror or any Acquiror  Subsidiary  to  repurchase,  redeem or
otherwise acquire any such securities or to issue,  deliver or sell, or cause to
be  issued,  delivered  or sold,  any  such  securities,  and  (iii)  except  as
contemplated in this Agreement,  Acquiror is not presently under any obligation,
has not agreed or committed,  and has not granted rights,  to register under the
Securities Act or the Exchange Act, or otherwise file any registration statement
under any such statute covering,  any of its currently outstanding capital stock
or other  securities or any of its capital stock or other securities that may be
subsequently issued.

                  (c)  Except  as  described  in  Schedule  5.3,  as of the date
hereof, neither Acquiror nor any Acquiror Subsidiary is a party to any agreement
granting any preemptive or antidilutive rights with respect to any securities of
Acquiror or any Acquiror  Subsidiary that are outstanding as of the date hereof,
or with respect to any  securities of Acquiror or any Acquiror  Subsidiary  that
may be  subsequently  issued upon the  conversion or exercise of any  instrument
outstanding as of the date hereof.  Other than Acquiror  Subsidiaries,  Acquiror
does  not  directly  or  indirectly  beneficially  own any  securities  or other
beneficial ownership interests in any other Person.

         SECTION 5.4. Authority.

                  Acquiror has the  necessary  corporate  power and authority to
enter into this  Agreement and,  subject to obtaining the requisite  approval of
the  stockholders  of Acquiror of the issuance of Acquiror Common Stock pursuant
to this Agreement if the aggregate  number of shares of Acquiror Common Stock to
be issued at Closing will exceed nineteen and nine-tenths percent (19.9%) of the
number of shares of  Acquiror  Common  Stock  issued and  outstanding  as of the
Closing Date (the  "Requisite  Acquiror  Approval"),  to perform its obligations
hereunder and to consummate the transactions  contemplated hereby. Except to the
extent Requisite  Acquiror Approval may be required,  the execution and delivery
of  this  Agreement  by  Acquiror  and  the  consummation  by  Acquiror  of  the
transactions  contemplated  hereby have been duly and validly  authorized by all
necessary  corporate action and no other proceedings on the part of Acquiror are
necessary  to  authorize  this  Agreement  or  to  consummate  the  transactions
contemplated  hereby.  This  Agreement  has been duly  executed and delivered by
Acquiror  and,  assuming the due  authorization,  execution  and delivery by the
Company and Merger Sub,  constitutes  a legal,  valid and binding  obligation of
Acquiror,   enforceable   in   accordance   with  its  terms,   except  as  such
enforceability  may  be  limited  by  bankruptcy,  insolvency,   reorganization,
moratorium  and other  similar  laws of  general  applicability  relating  to or
affecting  creditors'  rights  generally  and  by  the  application  of  general
principles  of equity.  Acquiror,  as the sole  stockholder  of Merger Sub,  has
approved the Merger and this Agreement.

         SECTION 5.5. No Conflict; Required Filings and Consents.

                  (a) The execution  and delivery of this  Agreement by Acquiror
do not, and the performance by Acquiror of its obligations  under this Agreement
will not, (i) conflict with or violate the articles of  incorporation  or bylaws
of Acquiror,  (ii) subject to obtaining the approvals  and  compliance  with the
requirements  set forth in Section 5.5 below,  conflict with or violate any law,
statute,  ordinance,  rule, regulation,  order, judgment or decree applicable to
Acquiror  or  any  Acquiror  Subsidiary  or by  which  any of  their  respective
properties  or assets  are bound or  affected,  or (iii)  except as set forth in
Schedule 5.5, result in any breach of or constitute a default (or an event which
with or without  notice or lapse of time or both would become a default)  under,
or  give to  others  any  rights  of  termination,  amendment,  acceleration  or
cancellation  of, or  result in the  creation  of an  Encumbrance  on any of the
properties  or assets of Acquiror  or any  Acquiror  Subsidiary  pursuant to any
note, bond, mortgage,  indenture,  contract,  agreement, lease, license, permit,
franchise or other  instrument or  obligation to which  Acquiror or any Acquiror
Subsidiary is a party or by which Acquiror or any of their respective properties
or assets are bound or affected,  except,  in the case of clauses (ii) and (iii)
above,  for  any  such  conflicts,   violations,  breaches,  defaults  or  other
alterations or occurrences  that would not (A) prevent or delay  consummation of
the Merger in any material respect or otherwise prevent Acquiror from performing
its  obligations  under this Agreement in any material  respect,  and (B) have a
Material Adverse Effect on Acquiror.

                  (b) The execution  and delivery of this  Agreement by Acquiror
does not, and the  performance of this  Agreement by Acquiror will not,  require
any  consent,   approval,   authorization  or  permit  of,  or  filing  with  or
notification to, any Governmental Entity by or with respect to Acquiror,  except
(i) for (A) applicable  requirements,  if any, of the  Securities  Act, Blue Sky
Laws,  Exchange Act, state takeover laws, the Nasdaq,  the NASD, the HSR Act and
the FDA,  (B)  applicable  requirements,  if any,  of the  consents,  approvals,
authorizations  or  permits  described  in  Schedule  5.5,  and (C)  filing  and
recordation of appropriate merger documents as required by Delaware Law and (ii)
where failure to obtain such consents, approvals,  authorizations or permits, or
to  make  such  filings  or  notifications,  would  not  (A)  prevent  or  delay
consummation  of the  Merger  in any  material  respect,  or  otherwise  prevent
Acquiror from  performing its  obligations  under this Agreement in any material
respect, and (B) have a Material Adverse Effect on Acquiror.

         SECTION 5.6. SEC Filings; Financial Statements.

                  (a)  Acquiror  has filed all forms,  reports,  statements  and
other  documents  required to be filed with the SEC since June 2, 1998,  and has
heretofore  delivered to the Company,  in the form filed with the SEC since such
date,  together  with any  amendments  thereto,  all of its and their (i) Annual
Reports  on Form  10-K,  (ii)  Quarterly  Reports  on  Form  10-Q,  (iii)  proxy
statements  relating to meetings of  stockholders  (whether  annual or special),
(iv) reports on Form 8-K and (v) other reports or registration  statements filed
by Acquiror and such  Acquiror  Subsidiaries  (collectively,  the  "Acquiror SEC
Reports").  As of their  respective  filing dates,  the Acquiror SEC Reports (i)
complied  as to form in all  material  respects  with  the  requirements  of the
Exchange Act and the Securities Act, as applicable, and (ii) did not at the time
they were filed contain any untrue statement of a material fact or omit to state
a  material  fact  required  to be  stated  therein  or  necessary  to make  the
statements  therein,  in the light of the  circumstances  under  which they were
made, not misleading.

                  (b)  The  audited   consolidated   financial   statements  and
unaudited interim financial  statements of Acquiror included in the Acquiror SEC
Reports   complied  in  all  material   respects  with   applicable   accounting
requirements  and with  the  published  rules  and  regulations  of the SEC with
respect  thereto.  The  financial  statements,  including  all related notes and
schedules,  contained in the Acquiror SEC Reports (or  incorporated by reference
therein)  present  fairly in all material  respects the  consolidated  financial
position of Acquiror and the Acquiror  Subsidiaries  as at the respective  dates
thereof and the  consolidated  results of operations  and cash flows of Acquiror
and the Acquiror Subsidiaries for the periods indicated, in accordance with GAAP
applied on a consistent  basis throughout the periods involved (except as may be
noted therein) and subject in the case of interim financial statements to normal
year-end adjustments.

         SECTION 5.7. No Undisclosed Liabilities.

                  Neither Acquiror nor any of the Acquiror  Subsidiaries has any
liabilities or obligations of any nature, whether or not accrued,  contingent or
otherwise,  except (a) liabilities or obligations  reflected in the Acquiror SEC
Reports  through the date of the filing of Acquiror's  Quarterly  Report on Form
10-Q in respect of the fiscal quarter ending September 30, 1999, (b) liabilities
or obligations  incurred in the ordinary course of business consistent with past
practice  since  September  30,  1999 which have not had,  and will not have,  a
Material  Adverse Effect on Acquiror and (c)  liabilities  or obligations  which
have not and will not have, a Material Adverse Effect on Acquiror.

         SECTION 5.8. Absence of Certain Changes or Events.

                  Except  as  disclosed  in  the  Acquiror  SEC  Reports,  since
September 30, 1999 there has not been any Material Adverse Effect on Acquiror.

         SECTION 5.9. Absence of Litigation.

                  Except as set forth in the Acquiror SEC Reports or on Schedule
5.9,  as  of  the  date  hereof  there  are  (a)  no  claims,   actions,  suits,
investigations,  or proceedings pending or, to Acquiror's knowledge,  threatened
against Acquiror or any Acquiror  Subsidiary  before any court,  administrative,
governmental,  arbitral,  mediation or regulatory authority or body, domestic or
foreign,  that would be reasonably  likely to have a Material  Adverse Effect on
Acquiror or that challenge or seek to prevent, enjoin, alter or materially delay
the  transactions  contemplated  hereby or by the Option  Agreement,  and (b) no
judgments,  decrees,  injunctions  or  orders  of  any  Governmental  Entity  or
arbitrator outstanding against Acquiror or any Acquiror Subsidiary that would be
reasonably likely to have a Material Adverse Effect on Acquiror.

         SECTION 5.10. Licenses and Permits; Compliance with Laws.

                  Acquiror  and the  Acquiror  Subsidiaries  hold  all  permits,
licenses,  franchises,  authorizations and approvals from Governmental  Entities
(the "Acquiror Permits") which are necessary for the operation of the businesses
of  Acquiror  and the  Acquiror  Subsidiaries  as  presently  conducted  and for
Acquiror  and  the  Acquiror  Subsidiaries  to  own,  lease  and  operate  their
respective  properties,  except  where  the  failure  to have any such  permits,
licenses or  approvals  would not have a Material  Adverse  Effect on  Acquiror.
Acquiror and the Acquiror  Subsidiaries  are in compliance with the terms of the
Acquiror  Permits  and all  applicable  statutes,  laws,  ordinances,  rules and
regulations,  except  where the  failure so to comply  would not have a Material
Adverse Effect on Acquiror.

         SECTION 5.11. Unlawful Payments.

                  None of the Acquiror, any Acquiror Subsidiary, or any officer,
director,  employee,  agent  or  representative  of  Acquiror  or  any  Acquiror
Subsidiary  has made,  directly or  indirectly,  any bribe or kickback,  illegal
political  contribution,  payment  from  corporate  funds which was  incorrectly
recorded  on the books and  records  of  Acquiror  or any  Acquiror  Subsidiary,
unlawful payment from corporate funds to governmental or municipal  officials in
their  individual  capacities  for the purpose of affecting  their action or the
actions of the jurisdiction  which they represent to obtain favorable  treatment
in securing  business or licenses or to obtain  special  concessions of any kind
whatsoever,  or illegal  payment  from  corporate  funds to obtain or retain any
business.

         SECTION 5.12. Taxes.

                  Acquiror and the Acquiror Subsidiaries have prepared and filed
on a timely  basis  with all  appropriate  Governmental  Entities  all  material
returns,  reports,  information  statements and other  documentation  (including
extensions)  required to be filed by Acquiror and the Acquiror  Subsidiaries) in
respect of Taxes (the "Tax  Returns")  and all such Tax  Returns are correct and
complete in all material respects.  Acquiror and the Acquiror  Subsidiaries have
paid in full all Taxes due (other than  Taxes,  the failure of which to pay have
not had and are not  reasonably  likely  to have a  Material  Adverse  Effect on
Acquiror) and, in the case of material Taxes accruing but not due,  Acquiror has
made adequate  provision in its books and records and financial  statements  for
such payment.

         SECTION 5.13. Intellectual Property.

                  (a)  Acquiror's  disclosure  in the  Acquiror SEC Reports with
respect to all of the computer software,  computer  firmware,  computer hardware
(whether  general or special  purpose),  and other  similar or related  items of
automated, computerized, and/or software system(s) that are used or relied on by
Acquiror or any Acquiror  Subsidiary in the  administration and conduct of their
respective  businesses does not contain any untrue  statement of a material fact
or omit to state a material fact  required to be stated  therein or necessary to
make the statements  therein, in the light of the circumstances under which they
were made, not misleading.

                  (b) To  Acquiror's  knowledge,  (i)  none of  Acquiror  or any
Acquiror Subsidiary is infringing on any Intellectual  Property right of others,
and (ii) no third party is infringing  on the  Intellectual  Property  rights of
Acquiror or any Acquiror Subsidiary, except for, in the case of (i) or (ii), any
infringement which would not have a Material Adverse Effect on Acquiror.

         SECTION 5.14. Environmental Matters.

                  (a) Except for matters which would not have a Material Adverse
Effect on Acquiror,  (i) Acquiror and each Acquiror  Subsidiary is in compliance
with all applicable  Environmental  Laws; (ii) neither Acquiror nor any Acquiror
Subsidiary has received any written  communication that alleges that Acquiror or
any Acquiror Subsidiary is not in compliance with applicable Environmental Laws;
(iii)  all  permits  and other  governmental  authorizations  currently  held by
Acquiror  and  each  Acquiror  Subsidiary  pursuant  to the  Environmental  Laws
("Acquiror  Environmental  Permits") are in full force and effect,  and Acquiror
and each  Acquiror  Subsidiary  is in  compliance  with all of the terms of such
Acquiror  Environmental  Permits,  and no other  permits  or other  governmental
authorizations  are  required  by Acquiror or any  Acquiror  Subsidiary  for the
conduct  of their  respective  businesses;  and (iv) the  management,  handling,
storage,  transportation,  treatment, and disposal by Acquiror and each Acquiror
Subsidiary  of any Hazardous  Materials is and has been in  compliance  with all
applicable Environmental Laws.

                  (b) Except for matters which would not have a Material Adverse
Effect on Acquiror,  there is no Acquiror Environmental Claim (as defined below)
pending  or, to the  knowledge  of  Acquiror,  threatened  against or  involving
Acquiror  or any of the  Acquiror  Subsidiaries  or  against  any  Person  whose
liability for any Acquiror  Environmental  Claim Acquiror or any of the Acquiror
Subsidiaries  has or may have  retained or assumed  either  contractually  or by
operation of law.

                  (c) Except for matters which would not have a Material Adverse
Effect on Acquiror,  to the knowledge of Acquiror,  there are no past or present
actions or activities by Acquiror or any Acquiror Subsidiary or any other Person
involving the storage,  treatment,  release,  emission,  discharge,  disposal or
arrangement for disposal of any Hazardous Materials,  that could reasonably form
the basis of any Acquiror  Environmental  Claim against Acquiror or any Acquiror
Subsidiary or against any Person whose liability for any Acquiror  Environmental
Claim  Acquiror or any Acquiror  Subsidiary  may have retained or assumed either
contractually or by operation of law.

                  (d) As used herein,  "Acquiror  Environmental Claim" means any
and all administrative,  regulatory or judicial actions,  suits, demands, demand
letters, directives,  claims, liens,  investigations,  proceedings or notices of
noncompliance  or  violation  (written  or oral) by any  Person or  Governmental
Entity alleging  potential  liability arising out of, based on or resulting from
the presence,  or release or threatened  release into the environment of, or any
exposure to, any Hazardous Materials at any property or location owned or leased
by Acquiror or any Acquiror Subsidiary or other circumstances  forming the basis
of any violation or alleged violation of any Environmental Law.

         SECTION 5.15. Brokers.

                  Except for Credit  Suisse First Boston,  no broker,  finder or
investment  banker  is  entitled  to any  brokerage,  finder's  or other  fee or
commission in connection  with the  transactions  contemplated by this Agreement
and the  Option  Agreement  based  upon  arrangements  made by or on  behalf  of
Acquiror.

         SECTION 5.16. Pooling; Tax Matters.

                  Neither Acquiror nor any of its Affiliates has taken or agreed
to take any action or failed to take any action  that would  prevent  the Merger
from (a) being  treated  for  financial  accounting  purposes  as a "pooling  of
interests" in accordance with GAAP and the regulations  and  interpretations  of
the SEC, or (b) from constituting a reorganization within the meaning of Section
368(a) of the Code.

         SECTION 5.17. Registration Statement; Proxy Statement/Prospectus.

                  The  information  supplied  by  Acquiror  or  required  to  be
supplied by Acquiror  (except to the extent  revised or superseded by amendments
or supplements) for inclusion in the Registration Statement, or any amendment or
supplement thereto, shall not, at the time the Registration Statement (including
any amendments or supplements thereto) is declared effective by the SEC, contain
any untrue  statement  of a  material  fact or omit to state any  material  fact
required  to be stated  therein  or  necessary  in order to make the  statements
therein,  in  light  of the  circumstances  under  which  they  were  made,  not
misleading.  The information  supplied by Acquiror or required to be supplied by
Acquiror   (except  to  the  extent  revised  or  superseded  by  amendments  or
supplements) for inclusion in the Proxy  Statement/Prospectus  shall not, on the
date  the  Proxy   Statement/Prospectus   is  first  mailed  to  the   Company's
stockholders  and at the Effective  Time,  contain any statement  which, at such
time, is false or misleading with respect to any material fact, or omit to state
any material fact  necessary in order to make the  statements  made therein,  in
light of the  circumstances  under which they are made, not false or misleading,
or omit to state any material  fact  necessary  to correct any  statement in any
earlier  communication  with  respect  to the  solicitation  of proxies by or on
behalf of the  Company  for the Company  Stockholders  Meeting  which has become
false or misleading.  The  Registration  Statement will comply as to form in all
material respects with the provisions of the Securities Act. Notwithstanding the
foregoing,  Acquiror makes no representation,  warranty or covenant with respect
to any  information  supplied or required to be supplied by the Company which is
contained in or omitted from any of the foregoing documents.

         SECTION 5.18. Disclosure.

                  No  representation  or warranty of Acquiror in this  Agreement
and no statement in Acquiror's disclosure schedules contains any statement which
is false or  misleading  with respect to any  material  fact or omits to state a
material fact  necessary to make the statements  herein or therein,  in light of
the circumstances in which they were made, not misleading.

                                   ARTICLE VI

                                    COVENANTS

         SECTION 6.1. Affirmative Covenants of the Company.

                  The Company  hereby  covenants  and agrees that,  prior to the
Effective Time,  unless  otherwise  expressly  contemplated by this Agreement or
consented to in writing by  Acquiror,  the Company  shall,  and shall cause each
Company Subsidiary to: (a) operate its business in the usual and ordinary course
consistent with past practices;  (b) use its commercially  reasonable efforts to
preserve substantially intact its business organization, maintain its rights and
franchises,  retain the services of its  respective  officers and  employees and
maintain its relationship with its respective customers,  suppliers,  licensors,
licensees,  distributors and others having business  dealings with them with the
intention  that its goodwill and ongoing  business  shall be  unimpaired  at the
Effective Time; (c) use its commercially reasonable efforts to maintain and keep
its  properties  and  assets in as good  repair  and  condition  as at  present,
ordinary wear and tear excepted; (d) use its commercially  reasonable efforts to
keep in full  force and  effect  insurance  comparable  in  amount  and scope of
coverage  to that  currently  maintained;  (e)  prepare and file all Tax Returns
required to be filed in a timely manner,  and in a manner  consistent  with past
practices and applicable laws and regulations;  (f) timely file with the SEC all
reports  required to be filed under the Exchange Act,  which reports  (including
the unaudited  interim  financial  statements  included in such  reports)  shall
comply in all material respects with the Exchange Act, the rules and regulations
promulgated thereunder and all applicable accounting  requirements;  (g) operate
its  business in  accordance  with the terms of its licenses and in all material
respects with all applicable  laws,  rules and  regulations;  (h) use reasonable
efforts consistent with prudent business practices and the past practices of the
Company to cause the cash reserves  calculated  pursuant to Section 8.2(f)(i) to
exceed Fifty Six Million Five Hundred Thousand Dollars ($56,500,000) immediately
following the Effective  Time;  (i) provide  Acquiror with copies of all filings
and  correspondence  with any  Governmental  Entities  with  respect  to Company
Intellectual  Property  with a  reasonable  period  for  Acquiror  to review and
comment  on such  filings  or  correspondence  prior to the  filing  or  sending
thereof;  and (j) if requested  by  Acquiror,  provide  Acquiror  with  periodic
reports regarding the status of the Company Intellectual Property.

         SECTION 6.2. Negative Covenants of the Company.

                  Except  as  expressly   contemplated   by  this  Agreement  or
otherwise  consented to in writing by  Acquiror,  from the date hereof until the
Closing Date, the Company shall not, and shall cause each Company Subsidiary not
to, do any of the following:

                  (a)  declare  or pay  any  dividend  on,  or  make  any  other
distribution in respect of, outstanding shares of its capital stock;

                  (b) (i) redeem,  repurchase or otherwise  reacquire any shares
of its  capital  stock or other  securities  or any  securities  or  obligations
convertible  into or  exchangeable  for any share of its capital  stock or other
securities,  or any options,  warrants or  conversion or other rights to acquire
any shares of its capital stock or other  securities  or any such  securities or
obligations  (except in connection  with the exercise of outstanding  Options in
accordance with their respective terms); (ii) effect any merger,  consolidation,
restructuring,  reorganization or recapitalization,  or adopt a plan of complete
or partial  liquidation  or  dissolution;  or (iii)  adjust,  split,  combine or
reclassify  any of its  capital  stock or  issue or  authorize  or  propose  the
issuance of any other  securities in respect of, in lieu of, or in  substitution
for, shares of its capital stock or other securities;

                  (c) (i)  issue,  pledge,  deliver,  award,  grant or sell,  or
register  under the  Securities  Act or the Exchange  Act or otherwise  file any
registration  statement under any statute covering,  or authorize or propose the
issuance,  pledge, delivery, award, grant or sale of (including the grant of any
Encumbrances  on) or  registration  of or filing of any  registration  statement
covering  any  shares  of any  class of its  capital  stock or other  securities
(including  shares  held  in  treasury),  any  securities  convertible  into  or
exercisable  or  exchangeable  for any such shares or other  securities,  or any
rights,  warrants  or  options to acquire  any such  shares or other  securities
(except in connection with the exercise of outstanding  Options);  or (ii) amend
or otherwise modify the terms of any such rights, warrants or options;

                  (d) acquire or agree to acquire,  by merging or  consolidating
with, by  purchasing an equity  interest in or a portion of the assets of, or by
any other manner, (i) any business or any corporation,  partnership, association
or other business organization or division (other than a wholly-owned Subsidiary
of the Company)  thereof;  (ii) make or commit to make any capital  expenditures
other than capital  expenditures  not exceeding in the aggregate  Fifty Thousand
Dollars ($50,000.00) and which are solely for equipment,  furniture and fixtures
incurred in the ordinary course of business  consistent with past practices;  or
(iii) make or commit to make any loans, advances or capital contributions to, or
investments in, any other Person.

                  (e) sell,  lease,  exchange,  mortgage,  pledge,  transfer  or
otherwise encumber or dispose of, or agree to sell, lease,  exchange,  mortgage,
pledge,  transfer or otherwise encumber or dispose of, any of its assets, except
for sales of inventory in the ordinary  course of business and  consistent  with
past practices;

                  (f) (i) except as otherwise  contemplated by this Agreement or
as required to comply with applicable law, (ii) adopt, enter into,  terminate or
amend in any  material  respect  (A) any Company  Benefit  Plan or (B) any other
agreement, plan or policy involving the Company or the Company Subsidiaries, and
one or more of its current or former  directors,  officers or  employees;  (iii)
increase in any manner the  compensation,  bonus or fringe or other benefits of,
or pay any bonus to, any current or former officer, director or employee (except
for normal increases of cash compensation or cash bonuses in the ordinary course
of  business  consistent  with past  practice  that,  in the  aggregate,  do not
materially  increase  benefits  or  compensation  expenses of the Company or the
Company  Subsidiaries);  (iv) pay any benefit or amount not  required  under any
Company  Benefit Plan or any other benefit plan or arrangement of the Company or
the  Company  Subsidiaries  as in  effect  on the  date of this  Agreement;  (v)
increase in any manner the severance or termination pay of any current or former
director, officer or employee; (vi) enter into or amend any employment, deferred
compensation,  consulting,  severance, termination or indemnification agreement,
arrangement or  understanding  with any current or former  employee,  officer or
director;  (vii) grant any awards  under any bonus,  incentive,  performance  or
other  compensation  plan or arrangement or Benefit Plan (including the grant of
stock options,  "phantom"  stock,  stock  appreciation  rights,  "phantom" stock
rights stock based or stock  related  awards,  performance  units or  restricted
stock or the removal of existing  restrictions  in any Company  Benefit Plans or
agreements or awards made thereunder);  (viii) amend or modify any Option,  (ix)
take any action to fund or in any other way secure the  payment of  compensation
or benefits  under any employee  plan,  agreement,  contract or  arrangement  or
Benefit Plan;  (x) take any action to  accelerate  the vesting of payment of any
compensation or benefit under any Company Benefit Plan or (xi) materially change
any actuarial or other  assumption used to calculate  funding  obligations  with
respect to any pension plan or change the manner in which  contributions  to any
pension plan are made or the basis on which such contributions are determined;

                  (g)  propose or adopt any  amendments  to its  certificate  or
articles of incorporation or its bylaws;

                  (h) (i) make any change in any of its  methods of  accounting,
or (ii) make or rescind any express or deemed election relating to Taxes, settle
or compromise any claim,  action,  suit,  litigation,  proceeding,  arbitration,
investigation,  audit or  controversy  relating  to Taxes,  or change any of its
methods of reporting  income or deductions  for federal income tax purposes from
those  employed in the  preparation  of the  federal  income tax returns for the
taxable  year ended  December  31,  1998,  except,  in the case of clause (i) or
clause (ii), as may be required by law or GAAP;

                  (i) incur any  Indebtedness,  or prepay,  before the scheduled
maturity thereof, any long-term debt;

                  (j)  engage  in  any  transaction  with,  or  enter  into  any
agreement,  arrangement,  or understanding with, directly or indirectly,  any of
such entity's  Affiliates  which involves the transfer of consideration or has a
financial  impact  on such  entity,  other  than  pursuant  to such  agreements,
arrangements, or understandings existing on the date of this Agreement;

                  (k)   enter   into  any   contract,   agreement,   commitment,
arrangement,  lease  (including  with respect to personal  property),  policy or
other instrument  which,  had it been entered into as of the date hereof,  would
have been included as a Company Material Contract;

                  (l) enter into any contracts, agreements, binding arrangements
or understandings  relating to the  distribution,  sale,  license,  marketing or
manufacturing  by third  parties of the  products  of the Company or the Company
Subsidiaries,  or products licensed by the Company or the Company  Subsidiaries,
other  than  pursuant  to  any  such  contracts,  agreements,   arrangements  or
understandings  in  place  as of the  date of this  Agreement  (that  have  been
disclosed in writing to Acquiror  prior to the date hereof) in  accordance  with
their terms as of the date hereof;

                  (m)  except  for   transactions  in  the  ordinary  course  of
business,  terminate,  or amend or waive any provision of, any Company  Material
Contract;

                  (n)  (i)  pay,  discharge,   settle  or  satisfy  any  claims,
liabilities,   obligations  or  litigation  (absolute,   accrued,   asserted  or
unasserted,  contingent  or  otherwise),  other  than  the  payment,  discharge,
settlement or satisfaction  in the ordinary  course of business  consistent with
past  practice of claims for money  damages  which do not exceed Fifty  Thousand
Dollars  ($50,000)  in the  aggregate  or in  accordance  with  their  terms  or
liabilities  disclosed,  reflected  or  reserved  against  in  the  most  recent
consolidated financial statements (or the notes thereto) of the Company included
in the Company SEC Reports; (ii) cancel any indebtedness;  (iii) waive or assign
any claims or rights of material  value or (iv) waive any  benefits of, or agree
to modify in any respect (A) any  standstill or similar  agreements to which the
Company or any of the Company  Subsidiaries  is a party or (B) other than in the
ordinary course of business,  any confidentiality or similar agreements to which
the Company or any of the Company Subsidiaries is a party;

                  (o)  transfer  or license to any Person or  otherwise  extend,
amend or modify any rights to the Company Intellectual Property;

                  (p) take any action that is intended  or would  reasonably  be
expected to result in any of its  representations  and  warranties  set forth in
this  Agreement  being or becoming  untrue in any  material  respect at any time
prior to the Effective Time, or in any of the conditions to the Merger set forth
in Article VIII not being  satisfied or in a violation of any  provision of this
Agreement;

                  (q) take any action that would be reasonably likely to prevent
the Merger from being  accounted  for as a "pooling of  interests" in accordance
with GAAP;

                  (r) accelerate the collection of any accounts receivable; or

                  (s) agree in writing or otherwise to do any of the foregoing.

                                   ARTICLE VII

                             ADDITIONAL AGREEMENTS

         SECTION 7.1. Access and Information.

                  During the period from the date hereof to the  Effective  Time
(the  "Interim  Period"),  the Company and Acquiror  shall,  and shall cause the
Company Subsidiaries and the Acquiror Subsidiaries,  respectively, to, afford to
each other and their respective officers, employees,  accountants,  consultants,
legal counsel and other representatives reasonable access during normal business
hours  (and at such  other  times as the  parties  may  mutually  agree)  to the
properties,  executive  personnel and all  information  concerning the business,
properties,  contracts,  records  and  personnel  of the Company and the Company
Subsidiaries or Acquiror and the Acquiror  Subsidiaries,  as the case may be, as
such other party may reasonably request.

         SECTION 7.2. Confidentiality.

                  Acquiror and the Company each  acknowledge and agree that: (i)
all information  received by it (the "Receiving Party") from or on behalf of the
other  party  in  connection  with  the  transactions  contemplated  under  this
Agreement shall be deemed  received  pursuant to the  confidentiality  agreement
previously  executed  between  the Company and  Acquiror  (the  "Confidentiality
Agreement"),  (ii) such  Receiving  Party shall,  and shall cause its  officers,
directors, employees,  Affiliates,  financial advisors and agents to comply with
the   provisions  of  the   Confidentiality   Agreement  with  respect  to  such
information,  and (iii) the  provisions of the  Confidentiality  Agreements  are
hereby  incorporated  herein by  reference  with the same effect as if fully set
forth herein.

         SECTION 7.3. Proxy  Statement/Prospectus  and  Registration  Statement;
Company Stockholders Meeting.

                  (a)  As  soon  as  practicable  following  the  date  of  this
Agreement,  the Company  and  Acquiror  shall  prepare and file with the SEC the
Proxy Statement/Prospectus, and Acquiror shall prepare and file with the SEC the
Registration Statement in which the Proxy  Statement/Prospectus will be included
as a prospectus.  Each of the Company and Acquiror shall use its best efforts to
have the Registration  Statement  declared effective under the Securities Act as
promptly  as  practicable  after such  filing.  The  Company  shall use its best
efforts to cause the Proxy  Statement/Prospectus  to be mailed to the  Company's
stockholders  as promptly as  practicable  after the  Registration  Statement is
declared effective under the Securities Act. Acquiror also shall take any action
(other than qualifying to do business in any jurisdiction in which it is not now
so qualified or filing a general  consent to service of process)  required to be
taken under any applicable state securities laws in connection with the issuance
of Acquiror  Common  Stock in the  Merger,  and the  Company  shall  furnish all
information  concerning  the Company and the holders of Company  Common Stock as
may be reasonably requested in connection with any such action. No filing of, or
amendment  or   supplement   to,  the   Registration   Statement  or  the  Proxy
Statement/Prospectus  will be made by either Acquiror or the Company without the
other party's prior consent (which shall not be unreasonably  withheld,  delayed
or conditioned) and without  providing the other party the opportunity to review
and comment  thereon.  Acquiror  shall  advise the  Company,  promptly  after it
receives notice thereof, of the time when the Registration  Statement has become
effective or any  supplement  or amendment  has been filed,  the issuance of any
stop  order,  the  suspension  of the  qualification  of Acquiror  Common  Stock
issuable in connection with the Merger for offering or sale in any jurisdiction,
or any request by the SEC for amendment of the Proxy Statement/Prospectus or the
Registration  Statement or comments thereon and responses thereto or requests by
the SEC for additional  information.  If at any time prior to the Effective Time
any information relating to the Company or Acquiror,  or any of their respective
Affiliates,  officers  or  directors,  should be  discovered  by the  Company or
Acquiror  which should be set forth in an amendment or  supplement to any of the
Registration  Statement or the Proxy  Statement/Prospectus,  so that any of such
documents would not include any misstatement of a material fact or omit to state
any material  fact  necessary to make the  statements  therein,  in light of the
circumstances  under  which  they were made,  not  misleading,  the party  which
discovers such information shall promptly notify the other parties hereto and an
appropriate  amendment  or  supplement  describing  such  information  shall  be
promptly filed with the SEC and, to the extent required by law,  disseminated to
the stockholders of the Company and Acquiror.

                  (b) The Company shall,  as promptly as  practicable  after the
Registration  Statement is declared  effective  under the  Securities  Act, duly
call,  give  notice  of,  convene  and hold a meeting of its  stockholders  (the
"Company  Stockholders  Meeting")  in  accordance  with  Delaware  Law  and  its
certificate of incorporation and bylaws for the purpose of obtaining the Company
Stockholder  Approval and shall,  through its Board of  Directors,  declare that
this Agreement is advisable and recommend to its  stockholders  the approval and
adoption of this Agreement,  the Merger and the other transactions  contemplated
hereby;  provided,  however,  that the Board of Directors  of the Company  shall
submit this Agreement to the Company's stockholders, whether or not the Board of
Directors of the Company at any time  subsequent  to the date hereof  determines
that this Agreement is no longer  advisable or recommends that the  stockholders
of the  Company  reject it.  Unless the Board of  Directors  of the  Company has
withdrawn  its  recommendation  of this  Agreement in compliance  herewith,  the
Company shall use reasonable efforts to solicit from stockholders of the Company
proxies in favor of the approval and adoption of this  Agreement  and the Merger
and to secure the vote or consent of  stockholders  required by Delaware Law and
its certificate of incorporation  and bylaws to approve and adopt this Agreement
and the Merger.

         SECTION 7.4. HSR Act Matters.

                  Acquiror,  Merger  Sub and  the  Company  (as may be  required
pursuant to the HSR Act) promptly  will  complete all  documents  required to be
filed with the Federal  Trade  Commission  and the United  States  Department of
Justice in order to comply  with the HSR Act and,  not later than  fifteen  (15)
days after the date hereof,  together with the Persons, if any, who are required
to join in  such  filings,  shall  file  such  documents  with  the  appropriate
Governmental  Entities.  Acquiror,  Merger Sub and the  Company  shall  promptly
furnish all materials  thereafter  required by any of the Governmental  Entities
having jurisdiction over such filings, and shall take all reasonable actions and
shall file and use their best efforts to have declared effective or approved all
documents  and  notifications  with  any  such  Governmental  Entity,  as may be
required  under the HSR Act or other  federal  or state  antitrust  laws for the
consummation of the Merger and the other transactions contemplated hereby and by
the Option Agreement.  Acquiror and the Company shall each pay one-half (1/2) of
all filing fees related to compliance  with the HSR Act in  connection  with the
transactions contemplated hereby.

         SECTION 7.5. Public Announcements.

                  Acquiror and the Company  shall consult with each other before
issuing any press release or otherwise making any public statements with respect
to the  transactions  contemplated  hereunder and shall not issue any such press
release or make any such public statement prior to such consultation,  except as
may be required by law or any listing agreement.

         SECTION 7.6. Indemnification.

                  (a)  The  certificate  of  incorporation  and  bylaws  of  the
Surviving   Corporation   shall   contain  the   provisions   with   respect  to
indemnification  set forth in the certificate of incorporation and bylaws of the
Company on the date of this Agreement,  which  provisions  shall not be amended,
repealed or otherwise modified for a period of six (6) years after the Effective
Time in any manner that would adversely affect the rights  thereunder of persons
who at any time  prior to the  Effective  Time were  identified  as  prospective
indemnitees  under the certificate of  incorporation or bylaws of the Company in
respect of actions or  omissions  occurring  at or prior to the  Effective  Time
(including,   without   limitation,   the  transactions   contemplated  by  this
Agreement),  unless such  modification is required by applicable law;  provided,
however,  that,  notwithstanding  the  foregoing  and the  provisions  regarding
indemnification  set forth in the certificate of incorporation and bylaws of the
Company as of the date of this Agreement,  the certificate of incorporation  and
bylaws  of  the  Surviving   Corporation  may  contain  provisions   prohibiting
indemnification  in respect of actions or  omissions if the person that would be
entitled  to  such  indemnification  shall  have  been  adjudged  to be  grossly
negligent or to have committed or engaged in willful misconduct.

                  (b) From and after the Effective  Time,  Acquiror  shall cause
the Surviving Corporation to indemnify, defend and hold harmless the present and
former  officers,  directors  and  employees  of the  Company  and  the  Company
Subsidiaries  (collectively,  the  "Indemnified  Parties")  against  all losses,
expenses,  claims,  damages,  liabilities or amounts that are paid in settlement
of, with the approval of Acquiror or otherwise in  connection  with,  any claim,
action, suit, proceeding or investigation (a "Claim"), based in whole or in part
on the fact that such person is or was such a director,  officer or employee and
arising out of actions or omissions  occurring at or prior to the Effective Time
(including,   without   limitation,   the  transactions   contemplated  by  this
Agreement), in each case to the fullest extent permitted under Delaware Law (and
shall pay  expenses  in advance of the final  disposition  of any such action or
proceeding  to each  Indemnified  Party to the fullest  extent  permitted  under
Delaware  Law,  upon receipt  from the  Indemnified  Party to whom  expenses are
advanced  of the  undertaking  to repay such  advances  contemplated  by Section
145(e) of Delaware Law), provided,  however,  that no Indemnified Party shall be
entitled  to any  indemnification  or expenses  pursuant to this  Section 7.6 in
respect of any Claim,  issue or matter as to which such Indemnified  Party shall
have been  adjudged to be grossly  negligent or to have  committed or engaged in
willful misconduct.

                  (c) Any  Indemnified  Party  wishing to claim  indemnification
under this Section 7.6,  promptly upon learning of any such Claim,  shall notify
Acquiror  and the  Surviving  Corporation  (although  the  failure  so to notify
Acquiror  and the  Surviving  Corporation  shall not  relieve  Acquiror  and the
Surviving  Corporation  from any  liability  which  Acquiror  and the  Surviving
Corporation  may have under this Section 7.6,  except to the extent such failure
prejudices  Acquiror  and the  Surviving  Corporation),  and  shall  deliver  to
Acquiror and the Surviving  Corporation the undertaking  contemplated by Section
145(e) of Delaware Law.

                  (d)  Notwithstanding any contrary provision of this Agreement,
prior to the  Effective  Time,  the  Company  may  purchase  insurance  coverage
extending for a period of six (6) years the Company's  directors'  and officers'
liability  insurance  coverage in effect as of the date hereof (covering past or
future  claims with  respect to periods  prior to and  including  the  Effective
Time);  provided that the aggregate premium payable for such insurance shall not
exceed 125% of the last annual  premium paid for such coverage prior to the date
hereof.

         SECTION 7.7. Further Action; Commercially Reasonable Efforts.

                  (a) Each of the  parties  hereto  shall  use all  commercially
reasonable  efforts to take, or cause to be taken, all appropriate  action,  and
do,  or cause to be done,  all  things  necessary,  proper  or  advisable  under
applicable  laws or otherwise to consummate and make effective the  transactions
contemplated  by this Agreement as promptly as practicable,  including,  without
limitation,  using  all  its  commercially  reasonable  efforts  to  obtain  all
licenses,  permits,  consents,  approvals,  authorizations,  qualifications  and
orders of  Governmental  Entities  and parties to  contracts  with the  Company,
Acquiror or any Company  Subsidiary or Acquiror  Subsidiary as are necessary for
the transactions  contemplated  herein.  In case at any time after the Effective
Time any further  action is  necessary or desirable to carry out the purposes of
this  Agreement,  the  proper  officers  and  directors  of each  party  to this
Agreement shall use all commercially reasonable efforts to take all such action.

                  (b) During the  Interim  Period,  each of the  parties  hereto
shall  promptly  notify the other in writing of any pending or, to the knowledge
of  such  party,   threatened   action,   proceeding  or  investigation  by  any
Governmental  Entity or any other Person (i)  challenging or seeking  damages in
connection  with the Merger or the  conversion of Company  Common Stock into the
Merger  Consideration  pursuant  to the Merger,  or (ii)  seeking to restrain or
prohibit the consummation of the Merger or any of the transactions  contemplated
by this  Agreement  or the  Option  Agreement  or  otherwise  limit the right of
Acquiror to own or operate  all or any portion of the  business or assets of the
Company.

                  (c) Each party  hereto shall use its  commercially  reasonable
efforts to refrain  from taking any action,  or entering  into any  transaction,
which would cause any of its  representations  or  warranties  contained in this
Agreement to be untrue or which would result in a breach of any covenant made by
it in this Agreement.

         SECTION 7.8. No Solicitation.

                  (a) From the date of this  Agreement  until the Effective Time
or the  termination of this Agreement  pursuant to the terms of this  Agreement,
the Company shall not and shall not permit any of its Subsidiaries,  Affiliates,
directors,  officers,  employees, agents or representatives,  including, without
limitation,  any investment banker, attorney or accountant of the Company or any
of its Subsidiaries (collectively, "Representatives") directly or indirectly, to
(i) initiate,  solicit,  encourage or otherwise facilitate  (including by way of
furnishing  information),  any  inquiries or the making of any proposal or offer
that  constitutes,  or may  reasonably  be expected  to lead to, an  Acquisition
Proposal (as defined below), (ii) enter into or maintain or continue discussions
or negotiate  with any Person in  furtherance  of such inquiries or to obtain an
Acquisition  Proposal,  or (iii) agree to,  approve,  recommend,  or endorse any
Acquisition Proposal, or authorize or permit any of its or their Subsidiaries or
Representatives  to take any such action and, the Company shall promptly  notify
Acquiror of any such  inquiries and proposals  received by the Company or any of
its Subsidiaries or Representatives,  relating to any of such matters; provided,
however,  that the  foregoing  shall not  prohibit the Board of Directors of the
Company  from (A)  furnishing  information  to, or  engaging in  discussions  or
negotiations  with, any Person in response to an  unsolicited  bona fide written
Acquisition  Proposal; or (B) recommending such an unsolicited bona fide written
Acquisition  Proposal to the  stockholders  of the Company,  if, and only to the
extent that,  (w) the Board of Directors of the Company  concludes in good faith
(after consultation with its financial advisors) that such Acquisition  Proposal
would constitute a Superior Proposal (as hereinafter defined),  (x) the Board of
Directors  of the Company  determines  in good faith  (after  consultation  with
outside  legal  counsel)  that the failure to take such action would result in a
breach by the Board of Directors of the Company of its  fiduciary  duties to the
Company's  stockholders  under  applicable  law,  (y) prior to  furnishing  such
information to, or entering into  discussions or negotiations  with, such Person
the Company  provides prompt written notice to Acquiror to the effect that it is
furnishing  information to, or entering into  discussions or negotiations  with,
such Person  (which notice shall  identify the nature and material  terms of the
proposal),  and (z) prior to providing any  information or data to any Person in
connection  with an  Acquisition  Proposal  by any  such  Person,  the  Board of
Directors of the Company  receives from such Person an executed  confidentiality
agreement   with   provisions  no  less   favorable  to  the  Company  than  the
Confidentiality Agreement. The Company agrees that it will immediately cease and
cause to be terminated any existing  activities,  discussions,  or  negotiations
with any parties  regarding  any  Acquisition  Proposal.  The  Company  shall as
promptly as practicable  provide Acquiror with a copy of any written Acquisition
Proposal  received  and a  written  statement  with  respect  to any  nonwritten
Acquisition Proposal received, which statement shall include the identity of the
Person  making the  Acquisition  Proposal and the material  terms  thereof.  The
Company shall inform  Acquiror as promptly as  practicable  of any change in the
price,  structure,  form of  consideration  or  material  terms  and  conditions
regarding the  Acquisition  Proposal.  The Company agrees to keep Acquiror fully
and timely informed of the status of any discussions,  negotiations,  furnishing
of  non-public  information,  or other  activities  relating  to an  Acquisition
Proposal.

                  (b) For  purposes of this  Agreement,  "Acquisition  Proposal"
means an inquiry,  offer or proposal  regarding any of the following (other than
the  transactions  contemplated by this Agreement)  involving the Company or its
Subsidiaries:  (i) any merger,  reorganization,  consolidation,  share exchange,
recapitalization,  business  combination,  liquidation,  dissolution,  or  other
similar transaction involving, or, any sale, lease, exchange,  mortgage, pledge,
transfer or other  disposition of, all or any significant  portion of the assets
or ten percent (10%) or more of the equity  securities of, the Company or any of
its  Subsidiaries,  in a single  transaction  or series of related  transactions
which could  reasonably  be expected to  interfere  with the  completion  of the
Merger; (ii) any tender offer or exchange offer for twenty percent (20%) or more
of the  outstanding  shares  of  capital  stock of the  Company  or any  Company
Subsidiary or the filing of a registration statement under the Securities Act in
connection  therewith;  or (iii) any public announcement of a proposal,  plan or
intention to do any of the  foregoing  or any  agreement to engage in any of the
foregoing.

                  (c) For purposes of this Agreement,  "Superior Proposal" means
a bona fide Acquisition  Proposal made by any Person that the Board of Directors
of the Company determines in its good faith judgment to be more favorable to the
Company's  stockholders  than the Merger  (after  consideration  of, among other
things,  the  written  opinion,  with  only  customary  qualifications,  of  the
Company's  independent  financial advisor that the value of the consideration to
the Company's  stockholders  provided for in such proposal  exceeds the value of
the consideration to the Company's  stockholders provided for in the Merger) and
for which financing,  to the extent required, is then committed or which, in the
good faith  judgment  of the Board of  Directors  of the  Company  (based on the
advice of the Company's independent financial advisor), is reasonably capable of
being obtained by such Person.

                  (d) Nothing  contained in this Section 7.8 shall  prohibit the
Company from taking and disclosing to its  stockholders a position  contemplated
by Rule 14e-2  promulgated  under the Exchange Act or from making any disclosure
to the Company's  stockholders which, in the good faith judgment of the Board of
Directors  of the Company  based on the advice of outside  counsel,  is required
under  applicable  law;  provided  that in any such cases the  Company  does not
withdraw or modify, or propose to withdraw or modify,  its position with respect
to the Merger or approve or recommend,  or propose to approve or  recommend,  an
Acquisition Proposal unless the Company and its Board of Directors have complied
with all the provisions of this Section 7.8.

         SECTION 7.9. Nasdaq Listing.

                  Acquiror  shall use  reasonable  efforts to cause the Acquiror
Common  Stock to be issued  pursuant to Section  2.1(a) of this  Agreement to be
approved for listing on Nasdaq, subject to official notice of issuance, prior to
the Effective Time.

         SECTION 7.10. Blue Sky.

                  Acquiror shall use  reasonable  efforts to obtain prior to the
Effective Time any necessary permits and approvals under all applicable Blue Sky
Laws required to permit the  distribution of the shares of Acquiror Common Stock
to be  issued  in  accordance  with the  provisions  of  Section  2.1(a) of this
Agreement.

         SECTION 7.11. Affiliates.

                  (a) Each of the Company and Acquiror: (i) has disclosed to the
other in  Schedule  7.11  hereto all  Persons who are, or may be, as of the date
hereof its  "affiliates"  as that term is used in SEC Accounting  Series Release
Nos. 130 and 135 and Rule 145 of the rules and  regulations of the SEC under the
Securities  Act; and (ii) shall use all reasonable  efforts to cause each Person
who is  identified  as an  "affiliate"  of it in Schedule 7.11 to deliver to the
other as promptly as practicable but in no event later than thirty-one (31) days
prior to the Closing Date, a signed agreement substantially in the form attached
hereto as Exhibit A, in the case of the  Company,  and Exhibit B, in the case of
Acquiror.  The Company and Acquiror shall notify each other from time to time of
all other  Persons  who then are,  or may be,  such an  "affiliate"  and use all
reasonable  efforts to cause each  additional  Person  who is  identified  as an
"affiliate" to execute a signed agreement as set forth in this Section 7.11(a).

                  (b) Shares of  Company  Common  Stock and  shares of  Acquiror
Common  Stock held by the  "affiliates"  of the Company or Acquiror set forth in
Schedule 7.11, as the case may be, shall not be  transferable  during the thirty
(30) day period prior to the Effective Time, and shares of Acquiror Common Stock
issued to, or as of the Effective Time held by, such "affiliates" of the Company
and Acquiror  shall not be  transferable  until such time as  financial  results
covering at least  thirty (30) days of  combined  operations  of the Company and
Acquiror have been  published  within the meaning of Section 201.01 of the SEC's
Codification of Financial  Reporting  Policies,  regardless of whether each such
"affiliate" has provided the signed  agreement  referred to in Section  7.11(a),
except to the extent permitted by, and in accordance with, SEC Accounting Series
Release 135 and SEC Staff  Accounting  Bulletins  65 and 76. Any Company  Common
Stock and any Acquiror  Common Stock held by any such  "affiliate"  shall not be
transferable, regardless of whether such "affiliate" has provided the applicable
signed agreement referred to in Section 7.11(a), if such transfer,  either alone
or in the aggregate  with other  transfers by  "affiliates",  would preclude the
ability of the  parties to account  for the  transactions  contemplated  by this
Agreement  and the Option  Agreement as a "pooling of  interests"  in accordance
with GAAP, Accounting Principles Board Opinion No. 16 and all rules, regulations
and policies of the SEC.  Acquiror shall not register the transfer of any shares
of Acquiror  Common Stock unless such  transfer is made in  compliance  with the
foregoing.

         SECTION 7.12. Event Notices.

                  During the Interim  Period,  each party  hereto will  promptly
notify the other parties  hereto of (a) the occurrence or  nonoccurrence  of any
event the  occurrence  or  nonoccurrence  of which  would be likely to cause any
condition  to the  obligations  of such party to effect the Merger and the other
transactions  contemplated  by this Agreement or the Option  Agreement not to be
satisfied  and (b) the  failure of such  party to comply  with any  covenant  or
agreement to be complied  with by it pursuant to this  Agreement  which would be
likely to result in any condition to the obligations of such party to effect the
Merger and the other  transactions  contemplated by this Agreement or the Option
Agreement  not to be  satisfied.  No  delivery  of any notice  pursuant  to this
Section 7.12 will cure any breach of any  representation or warranty,  covenant,
condition or agreement  of such party  contained in this  Agreement or otherwise
limit or affect the remedies  available  hereunder to the party  receiving  such
notice.

         SECTION 7.13. Option Agreement.

                  Concurrently with the execution of this Agreement, the Company
shall deliver to Acquiror an executed  Option  Agreement.  The Company agrees to
fully  perform  to  the  fullest  extent  permitted  under  applicable  law  its
obligations under the Option Agreement.

         SECTION 7.14. Tax Treatment.

                  Each of Acquiror and the Company shall use reasonable  efforts
to cause the Merger to  qualify  as a  reorganization  under the  provisions  of
Section 368 of the Code.  The  parties  will  characterize  the Merger as such a
reorganization for purposes of all Tax Returns and other filings.

         SECTION 7.15. Accountant Letters; Pooling of Interests.

                  (a)  Acquiror  shall  use  reasonable  efforts  to cause to be
delivered  to  the  Company  two  letters  from  Acquiror's  independent  public
accountants,  one  dated  approximately  the  date  on  which  the  Registration
Statement shall become  effective and one dated the Closing Date, each addressed
to Acquiror and the Company, in form reasonably  satisfactory to the Company and
customary  in  scope  for  comfort  letters  delivered  by  independent   public
accountants  in  connection  with   registration   statements   similar  to  the
Registration Statement.

                  (b) The Company  shall use  reasonable  efforts to cause to be
delivered  to  Acquiror  two  letters  from  the  Company's  independent  public
accountants,  one  dated  approximately  the  date  on  which  the  Registration
Statement shall become  effective and one dated the Closing Date, each addressed
to the Company and Acquiror,  in form  reasonably  satisfactory  to Acquiror and
customary  in  scope  for  comfort  letters  delivered  by  independent   public
accountants  in  connection  with   registration   statements   similar  to  the
Registration Statement.

                  (c) Each of the  Company  and  Acquiror  shall use  reasonable
efforts to cause the transactions contemplated by this Agreement,  including the
Merger, to be accounted for as a "pooling of interests" in accordance with GAAP,
Accounting Principles Board Opinion No. 16 and all published rules,  regulations
and  policies of the SEC,  and each of the Company and  Acquiror  agrees that it
shall  take no action  that  would  cause such  accounting  treatment  not to be
obtained.

         SECTION 7.16. Board of Directors of Acquiror.

                  Promptly  following the Effective Time, the Board of Directors
of Acquiror will take all actions  necessary such that Richard C. Williams shall
be appointed to Acquiror's  Board of Directors as a Vice Chairman of the Company
with a term expiring at the annual meeting of Acquiror's stockholders in 2001.

         SECTION 7.17. Rights Agreement.

                  The Board of Directors  of the Company  shall take all further
action (in addition to that referred to in Section 3.26) requested in writing by
Acquiror in order to render the Rights issued  pursuant to the Rights  Agreement
to  purchase  Company  Common  Stock  inapplicable  to the  Merger and the other
transactions  contemplated  by this  Agreement and the Option  Agreement and, if
requested by Acquiror,  to provide that the Final Expiration Date (as defined in
the Rights  Agreement)  shall occur  immediately  prior to the  Effective  Time.
Except as provided  above with respect to the Merger and the other  transactions
contemplated by this Agreement and the Option Agreement,  the Board of Directors
of the Company  shall not,  without the prior written  consent of Acquiror,  (a)
amend the Rights  Agreement  or (b) take any action with respect to, or make any
determination under, the Rights Agreement,  including a redemption of the Rights
or any action to facilitate an Acquisition Proposal.

         SECTION 7.18. Exemption from Liability Under Section 16(b).

                  (a) Provided that the Company delivers to Acquiror the Section
16  Information  with respect to the Company  prior to the Effective  Time,  the
Board of Directors of Acquiror, or a committee of Non-Employee Directors thereof
(as such term is defined for purposes of Rule 16b-3(d)  under the Exchange Act),
shall adopt a resolution in advance of the  Effective  Time  providing  that the
receipt by the Company  Insiders of Acquiror Common Stock in exchange for shares
of Company Common Stock,  and of options to purchase  Acquiror Common Stock upon
assumption  and  conversion  by Acquiror of options to purchase  Company  Common
Stock, in each case pursuant to the transactions  contemplated hereby and to the
extent such securities are listed in the Section 16 Information, are intended to
be exempt from liability pursuant to Rule 16b-3 under the Exchange Act.

                  (b) "Section 16 Information"  shall mean information  accurate
in all respects regarding the Company Insiders,  the number of shares of Company
Common Stock or other Company equity securities deemed to be beneficially  owned
by each such Company  Insider and expected to be exchanged  for Acquiror  Common
Stock in connection with the Merger.

                  (c) "Company Insiders" shall mean those officers and directors
of the Company who are subject to the reporting requirements of Section 16(a) of
the Exchange Act who are listed in the Section 16 Information.

         SECTION 7.19. Requisite Acquiror Approval.

                  If Requisite  Acquiror Approval becomes necessary and Acquiror
does not  exercise  Acquiror's  termination  right  pursuant to Section  9.1(l),
Acquiror shall (without waving any right to terminate this Agreement pursuant to
Section 9.1(l) or otherwise) use commercially  reasonable  efforts to duly call,
give  notice  of,  convene  and hold a meeting  of  Acquiror's  stockholders  in
accordance  with Tennessee  Business  Corporation  Act, the Securities  Act, the
Exchange  Act and  Acquiror's  articles of  incorporation  and  bylaws,  for the
purpose of obtaining Requisite Acquiror Approval. In connection  therewith,  the
Company shall use all  commercially  reasonable  efforts to take, or cause to be
taken,  all  appropriate  action,  and do,  or  cause  to be  done,  all  things
necessary,  proper and advisable under applicable laws or otherwise,  including,
without  limitation,  making timely filings with the SEC and other  Governmental
Entities  and, to the extent  necessary,  amending and  recirculating  the Proxy
Statement/Prospectus.

                                  ARTICLE VIII

                               CLOSING CONDITIONS

         SECTION 8.1. Conditions to Obligations of Acquiror,  Merger Sub and the
Company to Effect the Merger.

                  The  respective  obligations  of Acquiror,  Merger Sub and the
Company  to effect the Merger  and the other  transactions  contemplated  herein
shall be subject to the  satisfaction  at or prior to the Effective  Time of the
following conditions, any or all of which may be waived, in whole or in part, to
the extent permitted by applicable law:

                  (a) Stockholder  Approval.  The Company  Stockholder  Approval
shall have been obtained.

                  (b) Effectiveness of Registration Statement.  The Registration
Statement shall have been declared effective by the SEC under the Securities Act
prior to the  mailing of the Proxy  Statement/Prospectus  by each of the Company
and Acquiror to their  respective  stockholders and no stop order suspending the
effectiveness of such  registration  statement shall have been issued by the SEC
and no  proceedings  for that  purpose  shall  have  been  initiated  or, to the
knowledge of Acquiror or the Company, threatened by the SEC.

                  (c) No Order. No Governmental Entity or federal or state court
of competent jurisdiction shall have enacted, issued,  promulgated,  enforced or
entered any law, statute, rule, ordinance,  regulation, executive order, decree,
judgment, stipulation, injunction or other order (whether temporary, preliminary
or  permanent)  in any case which is in effect and which  prevents or  prohibits
consummation  of the  Merger  or any  other  transactions  contemplated  in this
Agreement;  provided,  however,  that the  parties  shall use  their  reasonable
efforts to cause any such decree, judgment, injunction or order to be vacated or
lifted.

                  (d) Nasdaq  Listing.  Acquiror  Common  Stock  issuable to the
holders of Company  Common Stock  pursuant to Section  2.1(a) of this  Agreement
shall have been included for listing on Nasdaq upon official notice of issuance.

                  (e) HSR Act. Any waiting  period with any  extensions  thereof
under the HSR Act shall have expired or been terminated.

                  (f) Company Pooling Letter. There shall have been delivered to
Acquiror and the Company a letter from the  Company's  independent  accountants,
dated  as of the  Closing  Date and  addressed  to  Acquiror,  the  Company  and
Acquiror's  independent   accountants,   reasonably  satisfactory  in  form  and
substance to Acquiror and Acquiror's independent accountants, to the effect that
(i) after reasonable  investigation,  the Company's independent  accountants are
not  aware  of  any  fact  concerning  the  Company  or  any  of  the  Company's
stockholders  or  "affiliates"  (as defined in Section 7.11) that could preclude
Acquiror  from  accounting  for  the  Merger  as a  "pooling  of  interests"  in
accordance  with  GAAP,  Accounting  Principles  Board  Opinion  No.  16 and all
published  rules,  regulations  and  policies of the SEC, and (ii) the Merger is
eligible to be accounted  for as a "pooling of  interests"  in  accordance  with
GAAP,  Accounting  Principles  Board  Opinion  No. 16 and all  published  rules,
regulations and policies of the SEC.

                  (g) Acquiror  Pooling Letter.  There shall have been delivered
to Acquiror and the Company a letter from  Acquiror's  independent  accountants,
dated as of the Closing Date and addressed to Acquiror,  reasonably satisfactory
in form and  substance  to  Acquiror,  to the effect  that (i) after  reasonable
investigation,  Acquiror's  independent  accountants  are not  aware of any fact
concerning  Acquiror  or any of  Acquiror's  stockholders  or  "affiliates"  (as
defined in Section 7.11) that could  preclude  Acquiror from  accounting for the
Merger  as  a  "pooling  of  interests"  in  accordance  with  GAAP,  Accounting
Principles  Board  Opinion  No.  16 and all  published  rules,  regulations  and
policies  of the SEC,  and (ii)  Acquiror's  independent  accountants  concur in
Acquiror's  management  conclusion that Acquiror may account for the Merger as a
"pooling of interests"  in accordance  with GAAP,  Accounting  Principles  Board
Opinion No. 16 and all published rules, regulations and policies of the SEC.

                  (h) Tax Opinion.  The Company and Acquiror shall have received
a legal opinion of the Company's counsel, on or before the date the Registration
Statement  shall become  effective and  subsequently on the Closing Date, to the
effect that the Merger will  constitute a  reorganization  within the meaning of
Section  368 of the  Code (it  being  understood  that,  (A) in  rendering  such
opinion,  the Company's legal counsel may rely upon tax  representation  letters
from each of  Acquiror,  Merger Sub and the Company,  in each case,  in form and
substance reasonably  satisfactory to such tax counsel, and (B) if the Company's
legal  counsel does not render such  opinion,  the  condition  set forth in this
Section shall  nonetheless be deemed to be satisfied if Acquiror's legal counsel
renders such an opinion to Acquiror).

                  (i)  Requisite  Acquiror   Approval.   If  Requisite  Acquiror
Approval  becomes  necessary,  the Requisite  Acquiror  Approval shall have been
obtained prior to the Extended Termination Date.

         SECTION  8.2.  Additional  Conditions  to  Obligations  of Acquiror and
Merger Sub.

                  The  obligations  of  Acquiror  and  Merger  Sub to effect the
Merger  and the  other  transactions  contemplated  in this  Agreement  are also
subject  to the  following  conditions,  any or all of which  may be  waived  by
Acquiror, in whole or in part, to the extent permitted by applicable law:

                  (a)  Representations  and Warranties.  The representations and
warranties  of the Company made in this  Agreement  shall be true and correct in
all  material  respects  when made and on and as of the Closing Date (except for
representations  and warranties that speak as of a specific date or time,  which
need only be true and correct in all material respects as of such date or time);
provided,  however, that, notwithstanding the foregoing, the representations and
warranties  of the Company set forth in Section 3.3 shall be true and correct in
all respects.  Acquiror shall have received a certificate of the Chief Executive
Officer or Chief Financial Officer of the Company to that effect.

                  (b) Agreements and Covenants.  The agreements and covenants of
the Company  required to be performed on or before the Effective Time shall have
been  performed  in all  material  respects.  Acquiror  shall  have  received  a
certificate of the Chief  Executive  Officer or Chief  Financial  Officer of the
Company to that effect.

                  (c) No  Material  Adverse  Changes.  There  shall have been no
Material Adverse Effect on the Company since the date of this Agreement.

                  (d) No  Litigation.  There shall not be pending or  threatened
any suit,  action,  proceeding or  investigation:  (i) challenging or seeking to
restrain  or  prohibit  the  consummation  of the  Merger  or  any of the  other
transactions  contemplated  by this  Agreement;  (ii) relating to the Merger and
seeking to obtain from Acquiror or any Acquiror  Subsidiary any damages that may
be  material to  Acquiror,  (iii)  seeking to prohibit or limit in any  material
respect  Acquiror's  ability  to vote,  receive  dividends  with  respect  to or
otherwise  exercise  ownership rights with respect to the stock of the Surviving
Corporation;  or (iv) which would  materially and adversely  affect the right of
the  Surviving  Corporation  to own the assets or operate  the  business  of the
Company.

                  (e) Consents Under Company Agreements.  The Company shall have
obtained the consent or approval of any Person whose  consent or approval  shall
be  required   under  any  agreement  or  instrument  in  order  to  permit  the
consummation of the  transactions  contemplated  hereby,  except those which the
failure to obtain would not have a Material Adverse Effect on the Company.

                  (f) Minimum Closing Cash Reserves;  Indebtedness.  Immediately
following the Effective  Time, the Company (i) shall have,  after payment of all
Transaction  Expenses,  at least  Fifty  Million  Dollars  ($50,000,000)  in the
aggregate of (A) cash on hand,  plus (B) liquid  investments  with a maturity of
three  months  or less,  plus  (C) with  respect  to any  marketable  securities
liquidated  by the Company in order to satisfy the condition set forth in clause
(i)(B),  the  amount  by which  the  Company's  book  value  of such  securities
immediately prior to such liquidation  exceeds the cash proceeds realized by the
Company from such liquidation;  provided, that the amount added pursuant to this
clause (i)(C) shall not exceed Two Hundred  Thousand  Dollars  ($200,000) in the
aggregate,  plus (D) the  outstanding  royalty  payments due to the Company from
Fujisawa  Healthcare,  Inc.  ("Fujisawa") for the fiscal quarter ending December
31, 1999,  to the extent not  collected;  provided,  that if the Closing  occurs
after March 31,  2000,  the amount  added  pursuant to this clause  (i)(D) shall
include the  outstanding  royalty  payments due to the Company from Fujisawa for
the fiscal quarter ending March 31, 2000, to the extent not collected,  plus (E)
the outstanding  royalty payments due from Sanofi Pharma (France)  ("Sanofi") to
the Company for the fiscal quarter  ending  December 31, 1999, to the extent not
collected; provided, that if the Closing occurs after March 3l, 2000, the amount
added  pursuant to this clause  (i)(E)  shall  include the  outstanding  royalty
payments due to the Company from Sanofi for the fiscal  quarter ending March 31,
2000,  to the extent not  collected,  plus (F) any  amounts  paid by the Company
after the date  hereof and prior to the  Closing  which  have been  specifically
acknowledged in writing by Acquiror as permitted to be included for the purposes
of this Section 8.2(f) as "cash on hand" of the Company as of Closing,  and (ii)
shall have no  Indebtedness.  Acquiror  shall have received a certificate of the
Chief  Financial  Officer  of the  Company to that  effect  and all  information
reasonably necessary for the Acquiror to determine the Company's satisfaction of
the  conditions  set forth in this  Section  8.1(f),  including  any releases or
waivers Acquiror deems reasonably  necessary from any Persons owed  Transactions
Expenses from the Company.

                  (g) Release of Oral Contracts. The Company shall have obtained
executed releases in form and substance  reasonably  satisfactory to Acquiror of
all oral agreements set forth on Schedule 3.14.

         SECTION 8.3. Additional Conditions to Obligations of the Company.

                  The  obligations  of the  Company to effect the Merger and the
other  transactions  contemplated  in this  Agreement  (except the  transactions
contemplated  in the  Option  Agreement)  are  also  subject  to  the  following
conditions  any or all of which  may be waived  by the  Company,  in whole or in
part, to the extent permitted by applicable law:

                  (a)  Representations  and Warranties.  The representations and
warranties of Acquiror and Merger Sub made in this  Agreement  shall be true and
correct in all  material  respects  when made and on and as of the Closing  Date
(except for  representations  and warranties that speak as of a specific date or
time,  which need only be true and correct in all  material  respects as of such
date and time.  The  Company  shall  have  received a  certificate  of the Chief
Executive Officer or Chief Financial Officer of Acquiror to such effect.

                  (b) Agreements and Covenants.  The agreements and covenants of
Acquiror and Merger Sub required to be performed on or before the Effective Time
shall have been  performed  in all  material  respects.  The Company  shall have
received a certificate of the Chief Executive Officer or Chief Financial Officer
of Acquiror to such effect.

                  (c) No  Material  Adverse  Change.  There  shall  have been no
Material Adverse Effect on Acquiror since the date of this Agreement.

         SECTION 8.4. Delayed Closing by the Company.

                  If the Closing  hereunder  shall not have occurred on or prior
to February 29, 2000, and all of the conditions to Closing  hereunder shall have
otherwise  been  satisfied  during  the  month of  March  2000  (except  for the
requirement  of the  Company  to  satisfy  the  condition  set forth in  Section
8.2(f)(i) (the "Cash-on-Hand Condition")),  then the Company, upon prior written
notice  delivered  to Acquiror at least five (5)  business  days before the date
which would otherwise be the Closing Date hereunder, shall have a one time right
to delay the Closing Date for a period of up to thirty-five  (35) days until the
date on which the  Cash-on-Hand  Condition  shall be satisfied (such notice from
the Company shall  designate the date to which the Company  delays the Closing).
Nothing in this Section 8.4 shall constitute or be deemed to constitute a waiver
of any  rights  or  conditions  set  forth  in this  Agreement  and the  parties
acknowledge  and agree that if the  Closing is delayed as  contemplated  in this
Section 8.4, all of the Closing  conditions  set forth in this Article VIII must
be satisfied or waived as of such delayed Closing Date.

                                   ARTICLE IX

                       TERMINATION, AMENDMENT AND WAIVER

         SECTION 9.1. Termination.

                  This  Agreement  may be  terminated  at any time  prior to the
Effective  Time,  whether  before or after  approval of this  Agreement  and the
Merger by the stockholders of the Company:

                  (a) by mutual consent of Acquiror and the Company;

                  (b) by Acquiror, upon a breach of any covenant or agreement on
the part of the Company set forth in this Agreement, or if any representation or
warranty of the Company shall have become  untrue,  in either case such that the
conditions  set forth in Section 8.2(a) or Section 8.2(b) would not be satisfied
(a "Terminating  Company Breach");  provided,  that, if such Terminating Company
Breach is curable by the Company through the exercise of reasonable  efforts and
for so long as the  Company  continues  to  exercise  such  reasonable  efforts,
Acquiror may not terminate this Agreement under this Section 9.1(b);

                  (c) by the  Company,  upon breach of any covenant or agreement
on the part of Acquiror set forth in this Agreement, or if any representation or
warranty of  Acquiror  shall have  become  untrue,  in either case such that the
conditions  set forth in Section 8.3(a) or Section 8.3(b) would not be satisfied
(a "Terminating Acquiror Breach");  provided, that, if such Terminating Acquiror
Breach is curable by Acquiror through the exercise of their  reasonable  efforts
and for so long as Acquiror continues to exercise such reasonable  efforts,  the
Company may not terminate this Agreement under this Section 9.1(c);

                  (d) by either  Acquiror or the Company,  if there shall be any
decree,  permanent injunction,  judgment,  order or other action by any court of
competent   jurisdiction  or  any   Governmental   Entity  which  is  final  and
nonappealable  preventing the  consummation  of the Merger;  provided,  that the
party seeking to terminate this Agreement  pursuant to this Section 9.1(d) shall
have used  reasonable  efforts to cause any such decree,  permanent  injunction,
judgment or other order to be vacated or lifted;

                  (e) by either Acquiror or the Company, if the Merger shall not
have been  consummated  on or before that date which is two hundred  forty (240)
calendar days after the date hereof;  provided,  however,  that if a request for
additional  information  is  received  from  the  United  States  Federal  Trade
Commission or the Antitrust  Division of the United States Department of Justice
pursuant  to the HSR Act,  then  such  date  shall be  extended  to the 30th day
following  certification  by Acquiror  and/or the Company,  as applicable,  that
Acquiror and/or the Company,  as applicable,  have  substantially  complied with
such  request,  but in any event not later than that date which is three hundred
(300) calendar days after the date hereof; provided,  further, that if Requisite
Acquiror  Approval  becomes  necessary,  then such date shall be extended to the
earlier  of  (i)  one  hundred  twenty  days  after  the  date  of  the  Company
Stockholders  Meeting  or (ii) the 120th  day  following  written  notice to the
Company from  Acquiror  that such  Requisite  Acquiror  Approval is required and
delivery by Acquiror to the Company of a voting agreement,  in substantially the
same form as the Voting  Agreement,  executed by the "affiliates" (as defined in
Section 7.11) of Acquiror,  pursuant to which such  affiliates  agree to vote in
favor of the issuance of shares of Acquiror  Common Stock in connection with the
Merger (such extended date for the Requisite  Acquiror  Approval,  the "Extended
Termination  Date");  provided,  further,  that  the  right  to  terminate  this
Agreement  under this  Section  9.1(e) shall not be available to any party whose
failure to fulfill any obligation under this Agreement has been the cause of the
failure of the Merger to occur on or before such date;

                  (f) by either  Acquiror or the Company,  if the requisite vote
of the  stockholders  of the Company in favor of this  Agreement  shall not have
been obtained at the Company  Stockholders Meeting (including any adjournment or
postponement  thereof);  provided,  that the right to terminate  this  Agreement
under this  Section  9.1(f) shall not be available to the Company if the Company
has not complied with its obligations under Section 7.3(b);

                  (g) by Acquiror,  if (i) the Board of Directors of the Company
withdraws  or modifies  its  recommendation  of this  Agreement or the Merger or
shall have  resolved or publicly  announced  or disclosed to any third party its
intention  to do any of the  foregoing  or the Board of Directors of the Company
shall have  recommended  to the  stockholders  of the  Company  any  Acquisition
Proposal or resolved to do so; (ii) the Board of Directors of the Company  fails
to reconfirm its  recommendation of this Agreement or the Merger within five (5)
Business Days of a written request by Acquiror to do so; (iii) a tender offer or
exchange  offer for twenty  percent (20%) or more of the  outstanding  shares of
Company  Common  Stock is  commenced or a  registration  statement  with respect
thereto shall have been filed and the Board of Directors of the Company,  within
ten (10) Business Days after such tender offer or exchange offer is so commenced
or such  registration  statement is so filed,  either fails to recommend against
acceptance  of such tender or  exchange  offer by its  stockholders  or takes no
position with respect to the  acceptance of such tender or exchange offer by its
stockholders,  or (iv) the Company  breaches in any material  respect the Option
Agreement;

                  (h) by the  Company,  if the Board of Directors of the Company
shall have determined to recommend an Acquisition  Proposal to its  stockholders
after  determining,  pursuant to Section  7.8,  that such  Acquisition  Proposal
constitutes a Superior  Proposal,  and the Company gives Acquiror at least three
(3)  Business  Days prior  notice of its  intention  to effect such  termination
pursuant to this  Section  9.1(h),  and the Company  makes the payment  required
pursuant to Section 9.5(b) of this Agreement and pays the expenses for which the
Company is responsible under Section 9.5(a) of this Agreement;

                  (i) by  Acquiror,  if any Person  (other than  Acquiror or any
Affiliate  of Acquiror  pursuant to the Option  Agreement)  shall have  acquired
beneficial  ownership or the right to acquire  beneficial  ownership  of, or any
"group" (as such term is defined under Section 13(d) of the Exchange Act and the
regulations promulgated  thereunder),  other than a "group" comprised of some or
all of the Persons listed on the signature pages to the Voting Agreement,  shall
have been formed which beneficially owns, or has the right to acquire beneficial
ownership of, twenty  percent  (20%) or more of the then  outstanding  shares of
capital stock of the Company;

                  (j) by  Acquiror,  if there  shall have  occurred  one or more
events which shall have caused a Material  Adverse  Effect on the Company  which
Material  Adverse Effect shall have remained uncured (to the extent curable) for
a period of thirty (30) days after  written  notice from  Acquiror of Acquiror's
intention to terminate pursuant to this Section 9.1(j);

                  (k) by the Company,  if there shall have  occurred one or more
events  which shall have  caused a Material  Adverse  Effect on  Acquiror  which
Material  Adverse Effect shall have remained uncured (to the extent curable) for
a period of thirty  (30) days  after  written  notice  from the  Company  of the
Company's intention to terminate pursuant to this Section 9.1(k);

                  (l) by  Acquiror,  if during a Twenty Day  Period (as  defined
below),  the Twenty Day  Average  Price (as  defined  below)  shall be less than
$30.00.  For purposes of this  Section  9.1(l),  (i) "Twenty Day Average  Price"
shall mean the  average of the  reported  closing  prices per share of  Acquiror
Common  Stock on the  Nasdaq  (or the last bid price in the  absence of a trade)
during twenty (20) consecutive  trading days, and (ii) "Twenty Day Period" means
any period of twenty  (20)  consecutive  trading  days for the  Acquiror  Common
Stock; or

                  (m) by Acquiror or the Company, if Requisite Acquiror Approval
becomes  necessary  but  is  not  obtained  at a  duly  called  meeting  of  the
stockholders  of  Acquiror  for  such  purpose  (including  any  adjournment  or
postponement thereof).

                  The right of any  party  hereto to  terminate  this  Agreement
pursuant to this Section 9.1 shall remain operative and in full force and effect
regardless of any  investigation  made by or on behalf of any party hereto,  any
Affiliate  of  such  party  or  any of  their  respective  officers,  directors,
representatives  or  agents,  whether  prior to or after the  execution  of this
Agreement.

         SECTION 9.2. Effect of Termination.

                  Except as provided in Section  9.5 of this  Agreement,  in the
event of the  termination  of this  Agreement  pursuant  to  Section  9.1,  this
Agreement shall forthwith  become void,  there shall be no liability on the part
of  Acquiror  or the  Company or any of their  respective  officers,  directors,
stockholders  or Affiliates to the other,  and all rights and obligations of any
party  hereto shall cease,  except that nothing  herein shall  relieve any party
from liability for any willful breach by a party of any of its  representations,
warranties,  covenants or  agreements in this  Agreement;  and provided that the
provisions  of Section  7.2 and  Section  9.5 of this  Agreement  and the Option
Agreement  will remain in full force and effect and survive any  termination  of
this Agreement.

         SECTION 9.3. Amendment.

                  This  Agreement may be amended by the parties hereto by action
taken or authorized by their respective Boards of Directors at any time prior to
the Effective Time; provided, however, that, after approval of the Merger by the
stockholders  of the  Company  or the  stockholders  of  Acquiror  if  Requisite
Acquiror  Approval becomes  necessary,  no amendment may be made which by law or
rule of Nasdaq  requires  further  approval by such  stockholders  without  such
further  approval.  This Agreement may not be amended except by an instrument in
writing signed by each of the parties hereto.

         SECTION 9.4. Extension; Waiver.

                  At any time prior to the Effective  Time, any party hereto may
(a) extend the time for the  performance of any of the obligations or other acts
of any other party hereto, (b) waive any inaccuracies in the representations and
warranties  of any other party  contained  herein or in any  document  delivered
pursuant  hereto  and (c) waive  compliance  by any other  party with any of the
agreements or conditions contained herein. Any such extension or waiver shall be
valid  only if set  forth in an  instrument  in  writing  signed by the party or
parties to be bond thereby.

         SECTION 9.5. Fees, Expenses and Other Payments.

                  (a) Except as otherwise set forth in this Agreement, all costs
and expenses  incurred by the parties  hereto shall be borne solely and entirely
by the party  which has  incurred  such costs and  expenses,  whether or not the
Merger is consummated;  provided,  however,  that Acquiror and the Company shall
share equally all costs and expenses  (other than  attorney's  and  accountants'
fees and  expenses)  incurred  in  relation  to  printing  and  filing  and,  as
applicable,    mailing    the    Registration    Statement    and   the    Proxy
Statement/Prospectus  and any amendments or supplements  thereto and all SEC and
other  regulatory  filing fees  incurred  in  connection  with the  Registration
Statement and the Proxy Statement/Prospectus and the fees required under the HSR
Act and  applicable  foreign  laws,  if any,  incurred  in  connection  with the
transactions contemplated under this Agreement.

                  (b) If this Agreement is terminated  (i) by Acquiror  pursuant
to Section 9.1(b),  (ii) by Acquiror pursuant to Section 9.1(g), or (iii) by the
Company  pursuant to Section  9.1(h),  then the Company  shall pay to Acquiror a
termination   fee  of  Twelve  Million  Dollars   ($12,000,000)   in  cash  (the
"Termination Fee"), immediately upon such termination.

                  (c) If this  Agreement is terminated  by Acquiror  pursuant to
Section  9.1(l),  then the Company  shall pay to Acquiror a fee equal to two (2)
times the  Acquiror  Transaction  Expenses in addition to any amounts  which may
become payable pursuant to Section 9.5(e);  provided,  however, that in no event
shall the fee payable pursuant to this Section 9.5(c) exceed Six Million Dollars
($6,000,000).  For  purposes  of  this  Section  9.5(c),  "Acquiror  Transaction
Expenses"  shall mean all  documented  costs,  fees,  expenses and other amounts
incurred or payable,  directly or  indirectly,  by Acquiror or any  Affiliate of
Acquiror in connection  with the Merger and this Agreement,  including,  without
limitation,  (i) all  reasonable  legal,  accounting,  brokerage and other fees,
costs and  expenses  incurred  for the benefit of Acquiror or any  Affiliate  of
Acquiror and (ii) all filing,  registration  and other similar fees and expenses
payable paid by or on behalf of Acquiror or any Affiliate of Acquiror.

                  (d) If this Agreement is terminated pursuant to Section 9.1(e)
as a result of the failure of the Company to timely fulfill any obligation under
this  Agreement,  and  if an  Acquisition  Proposal  involving  the  Company  is
thereafter  consummated or the Company  enters into a definitive  agreement with
respect  to an  Acquisition  Proposal  within  twelve  (12)  months  after  such
termination of this Agreement, the Company shall pay to Acquiror the Termination
Fee,  at  or  prior  to  the  consummation  of  such  Acquisition  Proposal,  or
immediately upon the effective date of such definitive  agreement,  whichever is
earlier.

                  (e) If this Agreement is terminated (i) by either  Acquiror or
the Company pursuant to Section 9.1(f) as a result of the failure to receive the
requisite vote for approval of this Agreement and the Merger by the stockholders
of the Company at the Company  Stockholders Meeting or (ii) by Acquiror pursuant
to  Section  9.1(l),  and,  in the case of clause  (i) or (ii),  an  Acquisition
Proposal  involving the Company is thereafter  consummated or the Company enters
into a definitive  agreement  with  respect to an  Acquisition  Proposal  within
twelve (12) months after such termination of this Agreement  pursuant to Section
9.1(f) or Section 9.1(l), as applicable,  then the Company shall pay to Acquiror
the Termination Fee at or prior to the consummation of such Acquisition Proposal
or immediately upon the effective date of such agreement, whichever is earlier.

                  (f) Any  payment  required  to be  made  pursuant  to  Section
9.5(b), Section 9.5(c), Section 9.5(d) or Section 9.5(e) of this Agreement shall
be made by wire transfer of immediately available funds to an account designated
by Acquiror.

                                    ARTICLE X

                               GENERAL PROVISIONS

         SECTION  10.1.   Effectiveness  of   Representations,   Warranties  and
Agreements.

                  (a) Except as set forth in Section  10.1(b) of this Agreement,
the representations,  warranties,  covenants and agreements of each party hereto
shall  remain  operative  and  in  full  force  and  effect  regardless  of  any
investigation  made by or on behalf of any other party hereto,  any Affiliate of
such  party or any of  their  officers,  directors,  representatives  or  agents
whether prior to or after the execution of this Agreement.

                  (b) The  representations and warranties in this Agreement will
terminate at the Effective Time;  provided,  however,  that this Section 10.1(b)
shall in no way limit or  terminate  any  covenant or  agreement  of the parties
which by its terms  contemplates  performance  after the Effective Time or after
the termination of this Agreement pursuant to Article IX.

         SECTION 10.2. Notices.

                  All notices and other  communications  given or made  pursuant
hereto  shall be in writing  and shall be deemed to have been duly given or made
as of the date  delivered,  mailed or  transmitted,  and shall be effective upon
receipt,  if  delivered  personally,  mailed by  registered  or  certified  mail
(postage  prepaid,  return  receipt  requested)  to the parties at the following
addresses  (or at such other  address for a party as shall be  specified by like
changes of address) or sent by electronic  transmission to the telecopier number
specified below:

                  (a)    If to Acquiror:

                         KING PHARMACEUTICALS, INC.
                         501 Fifth Street
                         Bristol, Tennessee  37620
                         Telecopier No.: (423) 989-8006
                         Attention:  Chief Executive Officer

                         and

                         Telecopier No.: (423) 989-6282
                         Attention: Executive Vice President and General Counsel

                         With a copy (which shall not constitute notice) to:

                         Hogan & Hartson L.L.P.
                         8300 Greensboro Drive
                         Suite 1100
                         McLean, Virginia 22102
                         Telecopier No.:  (703) 610-6200
                         Attention: Richard T. Horan, Jr., Esq.
                                    Thomas E. Repke, Esq.

                  (b)    If to the Company:

                         MEDCO RESEARCH, INC.
                         7001 Weston Parkway, Suite 300
                         Cary, North Carolina  27513
                         Telecopier No.: (919) 653-7022
                         Attention:  Richard C. Williams, Chairman

                         With a copy (which shall not constitute notice) to:

                         Hofheimer, Gartlier & Gross
                         530 Fifth Avenue
                         New York, New York  10036
                         Telecopier No.: (212) 661-3132
                         Attention:  Richard G. Klein, Esq.

         SECTION 10.3. Certain Definitions.

                  For purposes of this Agreement, the term:

                  (a)  "Affiliate" of any Person means a Person that directly or
indirectly,  through one or more intermediaries,  controls, is controlled by, or
is under common control with, the first mentioned Person;

                  (b)  "beneficial   owner"  (including  the  terms  "beneficial
ownership" and  "beneficially  own") means with respect to any shares of capital
stock,  a  Person  who  shall  be  deemed  to be the  beneficial  owner  or have
beneficial  ownership  of  such  shares  (i)  which  such  Person  or any of its
Affiliates or associates  beneficially owns, directly or indirectly,  (ii) which
such Person or any of its  Affiliates or associates  (as such term is defined in
Rule 12b-2 of the Exchange Act) has,  directly or  indirectly,  (A) the right to
acquire  (whether such right is  exercisable  immediately or subject only to the
passage of time),  pursuant to any agreement,  arrangement or  understanding  or
upon the exercise of conversion rights, exchange rights, warrants or options, or
otherwise,  or (B) the right to vote pursuant to any  agreement,  arrangement or
understanding,  (iii) which are beneficially owned,  directly or indirectly,  by
any other  Persons with whom such Person or any of its  Affiliates or associates
has any agreement,  arrangement or  understanding  for the purpose of acquiring,
holding voting or disposing of any such shares or (iv) pursuant to Section 13(d)
of the Exchange Act and any rules or regulations promulgated thereunder;

                  (c)  "Business  Day"  shall  mean any day other  than a day on
which banks in the State of New York are authorized or obligated to be closed;

                  (d) "control"  (including the terms "controlled by" and "under
common control with") means the possession, directly or indirectly or as trustee
or executor,  of the power to direct or cause the direction of the management or
policies of a Person,  whether  through the  ownership of stock or as trustee or
executor, by contract or credit arrangement or otherwise;

                  (e)  "Encumbrance"  shall  mean  any  lien,  pledge,   charge,
security interest or other encumbrance of any nature;

                  (f)  "Indebtedness" of a Person shall mean (i) indebtedness of
such Person for borrowed  money  whether  short-term  or  long-term  and whether
secured or unsecured, (ii) indebtedness of such Person for the deferred purchase
price of services or property,  which purchase price (A) is due twelve months or
more from the date of  incurrence of the  obligation  in respect  thereof or (B)
customarily  or  actually is  evidenced  by a note or other  written  instrument
(including,  without limitation,  any such indebtedness which is non-recourse to
the credit of such  Person but is secured by assets of such  Person);  provided,
that for  purposes of this  clause  (ii),  "Indebtedness"  shall not include (x)
amounts that may become due to a clinical  research  organization  in connection
with the  ordinary  course  annual  "true-up"  process  pursuant  to  which  the
Company's  actual  payments  for  services  rendered by such  clinical  research
organization to the Company are reconciled  against the actual services rendered
or (y) milestone payments or license fees payable by the Company pursuant to the
terms of the license agreements set forth on Schedule 3.13; (iii) obligations of
such Person under capital leases,  (iv) obligations of such Person arising under
acceptance facilities,  (v) the undrawn face amount of, and unpaid reimbursement
obligations  in respect of, all letters of credit issued for the account of such
Person,  (vi) all  obligations  of such Person  evidenced by bonds,  debentures,
notes or other similar  instruments,  (vii) all  obligations of such Person upon
which interest  charges are  customarily  paid,  (viii) all  obligations of such
Person under  conditional sale or other title retention  agreements  relating to
property  purchased  by such Person  (even though the rights and remedies of the
seller or lender  under such  agreement  in the event of default  are limited to
repossession  or sale of such  property),  (ix)  obligations  of such  Person to
purchase,  redeem,  retire,  defease or otherwise  acquire for value any capital
stock of such Person or any warrants,  rights or options to acquire such capital
stock  (with  redeemable  preferred  stock  being  valued at the  greater of its
voluntary  or  involuntary   liquidation  preference  plus  accrued  and  unpaid
dividends), (x) all executory obligations of such Person in respect of financial
hedge contracts (including,  without limitation,  equity hedge contracts),  (xi)
all  indebtedness  of the types referred to in clauses (i) through (x) above for
which such Person is obligated under a contingent obligation and (xii) renewals,
extensions, refundings, deferrals, restructurings,  amendments and modifications
of any such indebtedness, obligation or guarantee;

                  (g)  "Intellectual  Property" means all (i) patents and patent
applications,  (ii) trademarks,  service marks, trade dress, logos, trade names,
and corporate names and registrations and applications for registration thereof,
(iii) copyrights and  registrations  and applications for registration  thereof,
(iv)  computer  software,  data,  and  documentation,   (v)  trade  secrets  and
confidential business information (including formulas, compositions,  inventions
(whether  patentable  or  unpatentable  and whether or not reduced to practice),
know-how,  manufacturing and production  processes and techniques,  research and
development information,  drawings,  specifications,  designs, plans, proposals,
technical data,  copyrightable works, financial,  marketing,  and business data,
pricing and cost  information,  business and marketing  plans,  and customer and
supplier lists and information,  (vi) Internet domain names and applications for
domain names,  (vii) other  proprietary  rights,  and (viii) copies and tangible
embodiments thereof (in whatever form or medium);

                  (h) "Material  Adverse  Effect" shall mean,  with respect to a
specified  Person  any  change,  event or  effect  that  individually  or in the
aggregate  (taking into account all other such  changes,  events or effects) has
had, or would be  reasonably  likely to have, a material  adverse  effect on the
business, operations,  earnings, condition (financial or otherwise) or prospects
of such Person and its  Subsidiaries,  if any,  taken as a whole,  except to the
extent in the case of Acquiror  that any such change,  event or effect is caused
by a decline in the price of a share of Acquiror Common Stock or a change in the
trading volume of Acquiror Common Stock;

                  (i) "Person"  means an individual,  corporation,  partnership,
association,  trust,  unincorporated  organization,  other  entity  or group (as
defined in Section 13(d) of the Exchange Act);

                  (j) "reasonable  efforts" shall mean, as to a party hereto, an
undertaking  by such  party to  perform  or  satisfy  an  obligation  or duty or
otherwise act in a manner reasonably calculated to obtain the intended result by
action  or  expenditure  not   disproportionate  or  unduly  burdensome  in  the
circumstances,  which means,  among other  things,  that such party shall not be
required  to (i) expend  funds  other than for  payment  of the  reasonable  and
customary costs and expenses of employees, counsel, consultants, representatives
or agents of such party in connection  with the  performance or  satisfaction of
such  obligation  or duty  or  other  action  or (ii)  institute  litigation  or
arbitration as a part of its reasonable efforts; and

                  (k) "Tax"  (including,  with  correlative  meaning,  the terms
"Taxes"  and  "Taxable")  shall  include,  except  where the  context  otherwise
requires,  all federal,  state,  local and foreign income,  profits,  franchise,
gross receipts, payroll, sales, employment, use, property, withholding,  excise,
occupancy  and other  taxes,  duties  or  assessments  or  claims of any  nature
whatsoever,  together  with all interest,  penalties and additions  imposed with
respect to such amounts.

                  (l)  "Transaction   Expenses"  shall  mean  all  costs,  fees,
expenses and other  amounts  incurred or payable (or  reasonably  expected to be
incurred or payable), directly or indirectly, by the Company or any Affiliate of
the Company, in connection with the Merger, including,  without limitation,  (i)
all reasonable legal,  accounting,  brokerage and other fees, costs and expenses
incurred  for the  benefit  of the  Company  or any  Affiliate  of the  Company,
including,  without limitation,  the fees payable to Hambrecht & Quist LLC, (ii)
all filing,  registration  and other  similar  fees and  expenses  paid by or on
behalf  of the  Company  or any  Affiliate  of the  Company,  (iii) the fees and
expenses  payable to Richard C.  Williams or any other  amounts  payable  upon a
"change in control" of the Company or in connection with the consummation of the
transactions  contemplated  herein,  (iv) the adverse  consequences on the Taxes
payable by the  Company,  the  Surviving  Corporation  and/or the  Acquiror as a
result of the payment of the amounts  described in the  preceding  clause (iii),
(v) all  amounts  paid or  payable  in  connection  with  the  extension  of the
Company's  directors' and officers'  liability  insurance  coverage  pursuant to
Section 7.6(d) hereof,  and (vi) fees, costs and expenses  described on Schedule
10.3(l).

         SECTION 10.4. Headings.

                  The headings  contained in this  Agreement  are for  reference
purposes only and shall not affect in any way the meaning or  interpretation  of
this Agreement.

         SECTION 10.5. Severability.

                  If any term or other  provision of this  Agreement is invalid,
illegal or  incapable of being  enforced by any rule of law or public  policy or
other judgment, decree, injunction or order, all other conditions and provisions
of this Agreement shall nevertheless  remain in full force and effect so long as
the economic or legal substance of the transactions  contemplated  hereby is not
affected in any manner materially  adverse to any party. Upon such determination
that any term or other  provision  is  invalid,  illegal or  incapable  of being
enforced,  the  parties  hereto  shall  negotiate  in good faith to modify  this
Agreement  so as to effect  the  original  intent of the  parties  as closely as
possible  in an  acceptable  manner  to the end that  transactions  contemplated
hereby are fulfilled to the extent possible.

         SECTION 10.6. Entire Agreement.

                  This  Agreement  (together  with the Exhibits,  the Disclosure
Schedules  and the other  documents  delivered  pursuant  hereto) and the Option
Agreement and the Confidentiality  Agreement  constitute the entire agreement of
the parties and supersede all prior  agreements and  undertakings,  both written
and oral,  between  the  parties,  or any of them,  with  respect to the subject
matter  hereof and,  except as  otherwise  expressly  provided  herein,  are not
intended to confer upon any other Person any rights or remedies hereunder.

         SECTION 10.7. Specific Performance.
                  The  transactions  contemplated  by this Agreement are unique.
Accordingly,  the Company acknowledges and agrees that, in addition to all other
remedies to which  Acquiror or Merger Sub may be entitled,  each of Acquiror and
Merger Sub shall be entitled to a decree of specific performance.

         SECTION 10.8. Assignment.

                  Neither  this  Agreement  nor any of the rights,  interests or
obligations hereunder shall be assigned by any of the parties hereto (whether by
operation of law or otherwise)  without the prior  written  consent of the other
party. Subject to the preceding sentence,  this Agreement shall be binding upon,
inure to the benefit of and be enforceable  by the parties and their  respective
successors and assigns.

         SECTION 10.9. Third Party Beneficiaries.

                  Subject to Section 10.8,  this Agreement shall be binding upon
and inure  solely to the  benefit  of each  party  hereto,  and  nothing in this
Agreement,  express or implied,  is  intended to or shall  confer upon any other
Person any right,  benefit or remedy of any nature whatsoever under or by reason
of this Agreement.

         SECTION 10.10. Governing Law.

                  This  Agreement   shall  be  governed  by,  and  construed  in
accordance with, the laws of the State of Delaware,  regardless of the laws that
might otherwise govern under applicable principles of conflicts of law.

         SECTION 10.11. Counterparts.

                  This  Agreement  may be executed and  delivered in one or more
counterparts, and by the different parties hereto in separate counterparts, each
of which when executed and  delivered  shall be deemed to be an original but all
of which taken together shall constitute one and the same agreement.

             [The remainder of this page intentionally left blank.]
<PAGE>

                  IN WITNESS  WHEREOF,  the  parties  hereto  have  caused  this
Agreement  and Plan of Merger to be executed and  delivered as of the date first
written above.
                                          KING PHARMACEUTICALS, INC.


                                          By: /s/ John M. Gregory
                                          -----------------------------------
                                          Name:  John M. Gregory
                                          Title: Chairman of the Board &
                                                 Chief Executive Officer



                                          MEDCO RESEARCH, INC.


                                          By: /s/ Richard C. Williams
                                          -----------------------------------
                                          Name:  Richard C. Williams
                                          Title: Chairman



                                          MERLIN ACQUISITION I CORP.


                                          By: /s/ John M. Gregory
                                          -----------------------------------
                                          Name:  John M. Gregory
                                          Title: President
<PAGE>
                             Index of Defined Terms

                                                                     Section
                                                                     -------
Acquiror........................................................    PREAMBLE
Acquiror Common Stock...........................................    2.1(a)
Acquiror Permits................................................    5.10
Acquiror Environmental Claim....................................    5.14(d)
Acquiror Environmental Permits..................................    5.14(a)
Acquiror SEC Reports............................................    5.6(a)
Acquiror Stock Option Plans.....................................    5.3(a)
Acquiror Subsidiary and Acquiror Subsidiaries...................    5.1
Acquiror Transaction Expenses...................................    9.5(e)
Acquisition Proposal............................................    7.8(b)
Affiliate.......................................................    10.3(a)
Agreement.......................................................    PREAMBLE
Average Closing Price...........................................    2.1(a)
beneficial owner, beneficial ownership or beneficially own......    10.3(b)
Benefit Plans...................................................    3.15(a)
Blue Sky Laws...................................................    3.5(b)
Business Day....................................................    10.3(c)
Cash-on-Hand Condition..........................................    8.4
Certificate and Certificates....................................    2.2(b)
Certificate of Merger...........................................    1.2
Claim...........................................................    7.6(b)
Closing.........................................................    1.6
Closing Date....................................................    1.6
COBRA...........................................................    3.15(g)
Code............................................................    RECITALS
Company.........................................................    PREAMBLE
Company Benefit Plans...........................................    3.15(a)
Company Common Stock............................................    RECITALS
Company Commonly Controlled Entity..............................    3.15(a)
Company Environmental Claim.....................................    3.18(d)(i)
Company Environment Permits.....................................    3.18(a)
Company ERISA Plan..............................................    3.15(a)
Company Insiders................................................    7.18(c)
Company Intellectual Property...................................    3.13(a)
Company Material Contracts......................................    3.14(a)
Company Permits.................................................    3.10
Company Preferred Stock.........................................    3.3(a)
Company SEC Reports.............................................    3.6(a)
Company Stock Option Plan.......................................    2.3(a)
Company Stockholder Approval....................................    3.4
Company Stockholders Meeting....................................    7.3(b)
Company Subsidiary and Company Subsidiaries.....................    3.1(a)
Confidentiality Agreement.......................................    7.2
control, controlled by, under common control with...............    10.3(d)
CSA.............................................................    3.27(a)
Current Cash Reserves...........................................    3.28
DEA.............................................................    3.27(a)
Delaware Law....................................................    RECITALS
Due Investigation...............................................    3.13(a)
Effective Time..................................................    1.2
Encumbrance.....................................................    10.3(e)
Environmental Laws..............................................    3.18(d)(ii)
ERISA...........................................................    3.15(a)
Exchange Act....................................................    3.5(b)
Exchange Agent..................................................    2.2(a)
Exchange Fund...................................................    2.2(a)
Exchange Ratio..................................................    2.1(a)
Extended Termination Date.......................................    8.2(f)
FDA.............................................................    3.5(b)
FDCA............................................................    3.27(a)
Fujisawa........................................................    8.2(f)
GAAP............................................................    RECITALS
Governmental Entity.............................................    3.5(b)
Hazardous Materials.............................................    3.18(d)(iii)
HIPAA...........................................................    3.15(g)
HSR Act.........................................................    3.5(b)
Indebtedness....................................................    10.3(f)
Indemnified Parties.............................................    7.6(b)
Intellectual Property...........................................    10.3(g)
Interim Period..................................................    7.1
Material Adverse Effect.........................................    10.3(h)
Merger..........................................................    1.1
Merger Consideration............................................    2.1(a)
Merger Sub......................................................    PREAMBLE
Multiemployer Plan..............................................    3.15(d)
Nasdaq..........................................................    2.1(a)
NASD............................................................    4.4(b)
NYSE............................................................    3.5(b)
Option..........................................................    2.3(a)
Option Agreement................................................    RECITALS
Parachute Gross Up Payment......................................    3.15(f)
Person..........................................................    10.3(i)
Pharmaceutical Product..........................................    3.27(a)
PHSA............................................................    3.27(a)
Product Licensee................................................    3.27(a)
Proxy Statement/Prospectus......................................    3.25
Real Property Leases............................................    3.14(a)
reasonable efforts..............................................    10.3(j)
Receiving Party.................................................    7.2
Registration Statement..........................................    3.25
Representatives.................................................    7.8(a)
Requisite Acquiror Approval.....................................    5.4
Rights..........................................................    3.3
Rights Agreement................................................    3.3
Sanofi..........................................................    8.2(f)
SEC.............................................................    3.6(a)
Section 16 Information..........................................    7.18(b)
Securities Act..................................................    3.5(b)
Subsidiary......................................................    3.1(b)
Superior Proposal...............................................    7.8(c)
Surviving Corporation...........................................    1.1
Tax, Taxable and Taxes..........................................    10.3(k)
Tax Returns.....................................................    5.12
Terminating Acquiror Breach.....................................    9.1(c)
Terminating Company Breach......................................    9.1(b)
Termination Fee.................................................    9.5(b)
Transaction Expenses............................................    10.3(l)
Twenty Day Average Price........................................    9.1(l)
Twenty Day Period...............................................    9.1(l)
Voting Agreement................................................    RECITALS
1997 Plan.......................................................    5.3(a)
1998 Plan.......................................................    5.3(a)


                             STOCK OPTION AGREEMENT


         STOCK OPTION  AGREEMENT  (this  "Agreement"),  dated as of November 30,
1999, between MEDCO RESEARCH, INC., a Delaware corporation (the "Company"),  and
KING PHARMACEUTICALS, INC., a Tennessee corporation ("Grantee").

         WHEREAS,  the  Company,  Grantee  and  Merlin  Acquisition  I Corp.,  a
Delaware  corporation and a  newly-formed,  wholly-owned,  direct  subsidiary of
Grantee  ("Merger  Sub"),  have  contemporaneously  with the  execution  of this
Agreement  entered  into an  Agreement  and Plan of Merger  dated as of the date
hereof (the "Merger Agreement") which provides,  among other things, that Merger
Sub  shall be  merged  with  and into the  Company  pursuant  to the  terms  and
conditions thereof; and

         WHEREAS, as an essential condition and inducement to Grantee's entering
into the Merger Agreement and in consideration  therefor, the Company has agreed
to grant Grantee the Option (as hereinafter defined).

         NOW,  THEREFORE,  in  consideration  of the  foregoing  and the  mutual
covenants and agreements  contained herein and in the Merger Agreement,  and for
other good and valuable consideration,  the receipt and sufficiency of which are
hereby  acknowledged,  and  intending to be legally  bound  hereby,  the parties
hereby agree as follows:

         1. Grant of Option.

                  The Company  hereby  grants to Grantee an  irrevocable  option
(the "Option") to purchase up to Two Million Three Hundred Thirty-nine  Thousand
Six Hundred Ninety-two (2,339,692) validly issued, fully paid and non-assessable
shares of Company Common Stock (such shares,  as adjusted  pursuant to Section 7
of this Agreement,  the "Option  Shares"),  together with the associated  rights
(the "Rights") under the Rights Agreement,  dated as of April 14, 1998,  between
the  Company  and  American  Stock  Transfer & Trust  Company,  as Rights  Agent
(references  to the  Option  Shares  shall be deemed to include  the  associated
Rights),  at a purchase price of Thirty Dollars  ($30.00) per share (such price,
as  adjusted  pursuant  to Section 7 of this  Agreement,  the  "Option  Price");
provided,  however, that in no event shall the number of Option Shares for which
this Option is exercisable  exceed nineteen and  nine-tenths  percent (19.9%) of
the number of shares of Company  Common  Stock  issued and  outstanding  (before
giving  effect  to the  exercise  of the  Option)  at the time  this  Option  is
exercised.

         2. Certain Terms of the Option.

                  (a) Exercise of Option.  Grantee may  exercise the Option,  in
whole or part,  and from time to time,  if, but only if, a Triggering  Event (as
hereinafter  defined)  shall have occurred  prior to the occurrence of an Option
Termination  Event (as  hereinafter  defined);  provided that Grantee shall have
sent the written notice of such exercise (as provided in Section 2(e) hereof) on
or prior to the last date of the  eighteen  (18)  month  period  following  such
Triggering  Event (the  "Option  Expiration  Date").  The right to exercise  the
Option shall terminate upon the first to occur of the Option  Expiration Date or
an Option Termination Event.

                  (b) Triggering  Events. The term "Triggering Event" shall mean
the occurrence of the date, upon or after  termination of the Merger  Agreement,
on which Grantee's right, pursuant to Section 9.5(b),  Section 9.5(d) or Section
9.5(e) of the Merger Agreement, to receive the Termination Fee first arises.

                  (c) Option Termination  Events.  The term "Option  Termination
Event"  shall mean the  earlier  to occur of (i) the  Effective  Time;  (ii) the
termination  of the Merger  Agreement  pursuant to Section  9.1(l) of the Merger
Agreement;  or (iii) the  termination of the Merger  Agreement  other than under
circumstances  which constitute (or may constitute in the event of a termination
of the Merger  Agreement  pursuant  to Section  9.1(e) or Section  9.1(f) of the
Merger Agreement) a Triggering Event under this Agreement.

                  (d) Notice of  Triggering  Event.  The  Company  shall  notify
Grantee in writing as promptly as  practicable  following  the Company  becoming
aware of the occurrence of any Triggering  Event,  it being  understood that the
giving of such  notice by the Company  shall not be a condition  to the right of
Grantee to exercise the Option or for a Triggering Event to have occurred.

                  (e) Notice of Exercise;  Closing. In the event that Grantee is
entitled to and desires to  exercise  the Option (in whole or in part),  Grantee
shall send to the Company a written notice (such notice being herein referred to
as an  "Exercise  Notice" and the date of issuance of an Exercise  Notice  being
herein  referred to as the "Notice  Date")  specifying  (i) the total  number of
shares (or other  Option  Securities  (as  hereinafter  defined))  Grantee  will
purchase  pursuant to such  exercise  and (ii) a place and date not earlier than
three (3) Business Days nor later than sixty (60) Business Days after the Notice
Date for the closing of such purchase  (the "Option  Closing  Date");  provided,
that if the closing of the purchase and sale pursuant to the Option (the "Option
Closing") cannot be consummated by reason of any applicable Order, the period of
time that  otherwise  would run pursuant to this sentence shall run instead from
the  date  on  which  such  restriction  on  consummation  has  expired  or been
terminated;  provided,  further, without limiting the foregoing, that if, in the
reasonable  opinion  of  Grantee,  prior  notification  to or  approval  of  any
Governmental Entity is required in connection with such purchase, the Company or
Grantee,  as the  case  may be,  shall  promptly  file the  required  notice  or
application for approval and shall expeditiously process the same and the period
of time that  otherwise  would run pursuant to this  sentence  shall run instead
from the date on which any  required  notification  periods have expired or been
terminated or such approvals have been obtained and any requisite waiting period
or periods shall have passed.

                  (f) Payment of Purchase Price. Subject to Section 2(k), at any
Option Closing,  Grantee shall pay to the Company the aggregate Option Price for
the number of Option  Shares and Option  Securities  to be issued at such Option
Closing,  in  immediately  available  funds by wire  transfer to a bank  account
designated  by the Company;  provided  that failure or refusal of the Company to
designate  such a bank account shall not preclude  Grantee from  exercising  the
Option.

                  (g) Issuance of Company Common Stock. Subject to Section 2(k),
at any Option Closing, simultaneously with the delivery of immediately available
funds as provided in Section 2(f) hereof, the Company shall deliver to Grantee a
certificate or certificates  representing the number of shares of Company Common
Stock (or other Option  Securities)  purchased by Grantee at such Option Closing
and, if the Option should be exercised in part only, a new Option evidencing the
rights of Grantee thereof to purchase the balance of the Option Shares (or other
Option  Securities)  purchasable  hereunder.  If at the time of  issuance of any
Option  Shares  pursuant to an exercise of all or part of the Option  hereunder,
the Company shall have issued any rights or other  securities which are attached
to or otherwise  associated  with Company  Common Stock,  then each Option Share
issued  pursuant  to such  exercise  shall also  represent  such rights or other
securities  with terms  substantially  the same as and at least as  favorable to
Grantee  as are  provided  under any  shareholder  rights  agreement  or similar
agreement of the Company then in effect.

                  (h) Legend.  Certificates  for Company  Common Stock (or other
Option Securities) delivered at an Option Closing hereunder may be endorsed with
a restrictive legend that shall read substantially as follows:

                  "THE TRANSFER OF THE SHARES REPRESENTED BY THIS CERTIFICATE
                           IS SUBJECT TO RESALE RESTRICTIONS ARISING UNDER THE
                           SECURITIES ACT OF 1933, AS AMENDED."

It is understood and agreed that the reference to the resale restrictions of the
Securities  Act in the above legend  shall be removed by delivery of  substitute
certificate(s)  without such  reference if Grantee  shall have  delivered to the
Company a copy of a letter  from the staff of the SEC,  or an opinion of counsel
reasonably  satisfactory  to the Company,  to the effect that such legend is not
required for purposes of the Securities Act.

                  (i) Record Grantee;  Expenses. Upon the delivery by Grantee to
the Company of the Exercise Notice and the tender of the applicable Option Price
in  immediately  available  funds,  Grantee  shall be deemed to be the holder of
record of the  shares of  Company  Common  Stock  (or other  Option  Securities)
issuable upon such  exercise,  notwithstanding  that the stock transfer books of
the Company shall then be closed or that  certificates  representing such shares
of Company Common Stock (or other Option  Securities) shall not then be actually
delivered  to  Grantee  or that the  Company  shall  have  failed or  refused to
designate the bank account  described in Section 2(f). The Company shall pay all
expenses that may be payable in connection  with the  preparation,  issuance and
delivery  of stock  certificates  under this  Section 2 in the name of  Grantee.
Grantee  shall pay all  expenses  that may be  payable  in  connection  with the
issuance and delivery of stock  certificates or a substitute option agreement in
the name of any assignee, transferee or designee of Grantee.

                  (j)  Consents.  The  obligation of the Company to issue Option
Shares  (or other  Option  Securities)  to Grantee  hereunder  is subject to the
conditions  that (i) any  waiting  period  under the HSR Act  applicable  to the
issuance of the Option Shares (or other Option Securities)  hereunder shall have
expired or been terminated;  (ii) all material  consents,  approvals,  orders or
authorizations   of,  or  registrations,   declarations  or  filings  with,  any
Governmental  Entity,  if any,  required in connection  with the issuance of the
Option Shares (or other Option Securities) hereunder shall have been obtained or
made, as the case may be; and (iii) no  preliminary  or permanent  injunction or
other Order  prohibiting  or otherwise  restraining  such  issuance  shall be in
effect.  It is understood and agreed that at any time during which the Option is
exercisable,  the parties will use their  respective best efforts to satisfy all
such conditions to closing, so that an Option Closing may take place as promptly
as practicable.

                  (k) Cancellation  Amount.  If at any time while this Option is
exercisable  under Section 2(a),  any Person or group (other than Grantee or its
Affiliates)  (i) shall  have made a bona fide  proposal  with  respect  to (A) a
tender  offer or  exchange  offer  for fifty  percent  (50%) or more of the then
outstanding shares of Company Common Stock (a "Share  Proposal"),  (B) a merger,
consolidation  or  other  business  combination  with  the  Company  (a  "Merger
Proposal")  or (C) any  acquisition  of a material  portion of the assets of the
Company (an "Asset  Proposal"),  or (ii) shall have acquired fifty percent (50%)
or more of the then  outstanding  shares  of  Company  Common  Stock  (a  "Share
Acquisition"),  then Grantee,  in lieu of exercising the Option,  shall have the
right at any time  thereafter  (for so long as the Option is  exercisable  under
Section 2(a)) to request in writing (a  "Cancellation  Notice") that the Company
pay, and promptly (but in any event not more than five (5) Business  Days) after
the giving by Grantee of such  Cancellation  Notice,  the  Company  shall pay to
Grantee,  in  cancellation  of the  Option,  an  amount  in  cash  equal  to the
Cancellation Amount (as defined below). Notwithstanding anything to the contrary
in this  Agreement,  in the event of any  closing  involving  the  payment  of a
Cancellation  Amount,  Grantee shall deliver to the Company for cancellation the
Option, and the Company shall make payment to Grantee of the Cancellation Amount
by  wire  transfer  of  immediately   available   funds  pursuant  to  Grantee's
instructions.

                  As used herein, the "Cancellation Amount" shall mean an amount
equal to:

                           (i) the excess  over the Option  Price of the greater
         of (A) the  last  sale  price  of a share of  Company  Common  Stock as
         reported on the New York Stock  Exchange on the last  trading day prior
         to the date of the Cancellation Notice, or (B)(x) the highest price per
         share of Company Common Stock offered or proposed to be paid or paid by
         any such  Person or group  pursuant  to or in  connection  with a Share
         Proposal, a Share Acquisition or a Merger Proposal or (y) the aggregate
         consideration offered to be paid or paid in any transaction or proposed
         transaction in connection with an Asset Proposal, divided by the number
         of shares of Company Common Stock then outstanding,  multiplied by (ii)
         the number of Option  Shares then  covered by the  Option.  If all or a
         portion of the price per share of Company Common Stock offered, paid or
         payable or the aggregate consideration offered, paid or payable for the
         assets of the  Company,  each as  contemplated  by this  Section  2(k),
         consists   of   non-cash   consideration,   such  price  or   aggregate
         consideration  shall be the cash  consideration,  if any, plus the fair
         market value of the non-cash  consideration as determined by the mutual
         agreement of the  investment  bankers of the Company and the investment
         bankers of Grantee (or, if such investment  bankers cannot agree within
         ten  (10)  Business  Days of such  question  being  submitted  for such
         determination, then promptly by an independent investment banker chosen
         by  Grantee's  investment  bankers  and  reasonably  acceptable  to the
         Company's investment bankers).

                  3.  Evaluation  of  Investments.  Grantee,  by  reason  of its
knowledge  and  experience in financial and business  matters,  believes  itself
capable of  evaluating  the merits and risks of an  investment in the Option and
the securities to be  purchased/sold  pursuant to this Agreement  (collectively,
the "Option Securities").

                  4.  Investment  Intent.  Grantee  represents and warrants that
Grantee is entering into this Agreement and is acquiring and/or will acquire the
Option  Securities  for  Grantee's  own account and not with a view to resale or
distribution  of all or any  part  of the  Option  Securities  in  violation  of
applicable law.

         5. Reservation of Shares. The Company agrees (a) that the Company shall
at all times maintain,  free from preemptive rights,  sufficient  authorized but
unissued shares of Company Common Stock (and other Option  Securities)  issuable
pursuant  to  this  Agreement  so  that  the  Option  may be  exercised  without
additional   authorization  of  Company  Common  Stock  (or  such  other  Option
Securities)  after giving  effect to all other  options,  warrants,  convertible
securities  and other  rights to purchase  Company  Common  Stock (or such other
Option  Securities);  (b) that the Company  shall not, by charter  amendment  or
through reorganization, consolidation, merger, dissolution or sale of assets, or
by any other voluntary act, avoid or seek to avoid the observance or performance
of any of the  covenants to be observed or  performed  hereunder by the Company;
and (c)  promptly  to take all  action as may from time to time be  required  in
order to permit  Grantee to  exercise  the  Option  and the  Company to duly and
effectively  issue shares of Company  Common Stock (or other Option  Securities)
pursuant hereto.

         6. Division of Option;  Lost Options.  This  Agreement  (and the Option
granted hereby) are  exchangeable,  without  expense,  at the option of Grantee,
upon presentation and surrender of this Agreement at the principal office of the
Company, for other agreements  providing for Options of different  denominations
entitling  the holder(s)  thereof to purchase,  on the same terms and subject to
the same conditions as are set forth herein, in the aggregate the same number of
shares of  Company  Common  Stock  purchasable  hereunder.  Upon  receipt by the
Company of evidence  reasonably  satisfactory to the Company of the loss, theft,
destruction or mutilation of this Agreement,  and (in the case of loss, theft or
destruction) of reasonably satisfactory indemnification,  and upon surrender and
cancellation  of this  Agreement,  if  mutilated,  the Company  will execute and
deliver a new Agreement of like tenor and date.

         7. Adjustment Upon Changes in  Capitalization.  The number of shares of
Company  Common  Stock  purchasable  upon the  exercise  of the Option  shall be
subject to adjustment from time to time as provided in this Section 7.

                  (a)  Transaction  Adjustment.  In the  event of any  change in
Company   Common  Stock  by  reason  of  stock   dividends,   splits,   mergers,
recapitalizations,  combinations, subdivisions, conversions, exchanges of shares
or other similar transactions,  then the Option Shares that are then purchasable
upon  exercise of the Option  shall be  appropriately  adjusted so that  Grantee
shall receive upon  exercise of the Option and payment of the  aggregate  Option
Price  hereunder the number and class of shares or other  securities or property
(including cash) that Grantee would have owned or been entitled to receive after
the happening of any of the events  described in this Section 7(a) if the Option
had been exercised immediately prior to such event, or the record date therefor,
as applicable.

                  (b) Option Price Adjustment.  Whenever the number of shares of
Company  Common Stock  subject to this Option are  adjusted  pursuant to Section
7(a),  the Option  Price shall be  appropriately  adjusted,  if  applicable,  by
multiplying  the Option  Price by a fraction,  the  numerator  of which shall be
equal to the  aggregate  number of shares of Company  Common  Stock  purchasable
under the Option prior to the adjustment  and the  denominator of which shall be
equal to the  aggregate  number of shares of Company  Common  Stock  purchasable
under the Option immediately after the adjustment.

         8. Profit Limitation.

                  (a) Notwithstanding any other provision of this Agreement,  in
no event shall the Total Profit (as hereinafter defined) exceed in the aggregate
Seventeen Million Dollars ($17,000,000) (such amount, the "Maximum Profit") and,
if Grantee's Total Profit shall exceed such Maximum Profit, Grantee, at its sole
discretion, shall either (i) reduce the number of shares of Company Common Stock
subject to this  Option,  (ii)  deliver to the Company for  cancellation  Option
Shares (or other  securities  into which such  Option  Shares are  converted  or
exchanged)  previously  purchased  by Grantee,  (iii) pay cash to the Company or
(iv) any combination  thereof,  so that Grantee's actually realized Total Profit
shall not exceed the Maximum  Profit  after  taking into  account the  foregoing
actions.

                  (b) As used herein,  the term "Total  Profit" shall mean:  (i)
the  aggregate  amount of (A) any excess of (x) the net cash  proceeds  actually
received by Grantee  from the sale of Option  Shares (or  securities  into which
such shares are converted or exchanged) to any  unaffiliated  third party,  over
(y) the  aggregate  Option Price for such Option  Shares (or other  securities),
plus (B) the amount of the  Cancellation  Amount  actually  received  by Grantee
pursuant to Section 2(k) hereof,  plus (C) any Termination Fee actually received
by Grantee pursuant to the terms of the Merger Agreement,  minus (ii) the sum of
amounts of any cash  previously  paid to the Company  pursuant to this Section 8
plus the value of the Option Shares (or other securities)  previously  delivered
to the Company for cancellation pursuant to this Section 8.

                  (c)  Notwithstanding  any other  provision of this  Agreement,
nothing in this  Agreement  shall affect the ability of Grantee to receive,  nor
relieve the  Company's  obligation to pay, any  Termination  Fee provided for in
Sections 9.5(b), 9.5(d) or 9.5(e) of the Merger Agreement;  provided that if and
to the extent that the Total Profit received by Grantee would exceed the Maximum
Profit following receipt of such payment, Grantee shall be obligated to promptly
comply with the terms of Section 8(a).

         9. Registration Rights.

                  (a) The Company shall, if requested by Grantee at any time and
from time to time within two (2) years after a Triggering  Event, as promptly as
possible  (but in no event  later than  thirty  (30) days after  receipt of such
request)  prepare  and file up to three (3)  registration  statements  under the
Securities  Act to the  extent  necessary  in order to permit  the sale or other
disposition of any or all shares of securities that have been acquired by or are
issuable to Grantee upon exercise of the Option in accordance  with the intended
method of sale or other  disposition  stated  by  Grantee,  including  a "shelf"
registration  statement under Rule 415 under the Securities Act or any successor
provision,  and the Company  will use its best efforts to qualify such shares or
other  securities  under any applicable state securities laws. The Company shall
use best efforts to cause each such registration  statement to become effective,
to obtain all consents or waivers of other parties which are required  therefor,
and to keep such registration  statement  effective for a period of at least one
hundred  eighty (180) calendar days after the date such  registration  statement
first becomes  effective  (or such shorter  period as may be necessary to effect
such sale or other disposition).

                  (b)  The  obligations  of  the  Company  hereunder  to  file a
registration  statement and to maintain its  effectiveness  may be suspended for
one or more  periods  of time not  exceeding  sixty  (60)  calendar  days in the
aggregate if the Board of Directors of the Company shall have determined in good
faith  after  having  consulted  with  outside  counsel  that the filing of such
registration or the  maintenance of its  effectiveness  would require  premature
disclosure of material nonpublic information that would materially and adversely
affect  the  Company or the  Company is  required  under the  Securities  Act to
include  audited  financial  statements  for any  period  in  such  registration
statement and such  financial  statements are not yet available for inclusion in
such registration statement.

                  (c) In addition to such demand  registrations,  if the Company
proposes  to  effect a  registration  of  Company  Common  Stock  (other  than a
registration  statement  on Form S-4 or S-8 or any  successor  thereto)  for the
Company's  own  account  or for the  account  of any  other  stockholder  of the
Company,  the Company shall give prompt written notice to all holders of Options
or Option Shares of the Company's  intention to do so and shall use best efforts
to include therein all Option Shares requested by Grantee to be so included.  No
registration  effected  under this Section 9(c) shall relieve the Company of its
obligations to effect demand registrations under Section 9(a) hereof.

                  (d)  Registrations  effected  under  this  Section  9 shall be
effected at the Company's expense, including the fees and expenses of counsel to
the holder of Options or Option Shares, but excluding underwriting discounts and
commissions to brokers or dealers.  In connection with each  registration  under
this Section 9, the Company  shall  indemnify and hold each holder of Options or
Option Shares participating in such offering (a "Holder"),  its underwriters and
each of their respective affiliates harmless against any and all losses, claims,
damages, liabilities and expenses (including, without limitation,  investigation
expenses  and fees and  disbursements  of  counsel  and  accountants),  joint or
several,  to which such Holder,  its  underwriters  and each of their respective
Affiliates may become subject, under the Securities Act or otherwise, insofar as
such losses,  claims,  damages,  liabilities  or expenses (or actions in respect
thereof)  arise out of or are based upon an untrue  statement or alleged  untrue
statement of a material fact contained in any registration  statement (including
any prospectus therein), or any amendment or supplement thereto, or arise out of
or are based upon the omission or alleged  omission to state  therein a material
fact required to be stated therein or necessary to make the  statements  therein
not misleading, other than such losses, claims, damages, liabilities or expenses
(or actions in respect  thereof)  which arise out of or are based upon an untrue
statement or alleged  untrue  statement of a material fact  contained in written
information  furnished  by a Holder  to the  Company  expressly  for use in such
registration statement.

                  (e) In connection with any registration  statement pursuant to
this Section 9, each Holder agrees to furnish the Company with such  information
concerning  itself and the proposed sale or distribution as shall  reasonably be
required in order to ensure  compliance with the  requirements of the Securities
Act.  In  addition,  each  Holder  shall  indemnify  and hold the  Company,  its
underwriters  and each of their respective  Affiliates  harmless against any and
all  losses,  claims,  damages,  liabilities  and  expenses  (including  without
limitation  investigation  expenses  and fees and  disbursements  of counsel and
accountants),  joint or several, to which the Company, its underwriters and each
of their  respective  Affiliates  may become subject under the Securities Act or
otherwise,  insofar as such losses, claims, damages, liabilities or expenses (or
actions in respect  thereof) arise out of or are based upon an untrue  statement
or alleged untrue statement of a material fact contained in written  information
furnished by such Holder to the Company  expressly for use in such  registration
statement.  In no event  shall the  liability  of any  Holder  or any  Affiliate
thereof  under this Section 9 be greater in amount than the dollar amount of the
proceeds (net of payment of all expenses)  received by such Holder upon the sale
of the Option Shares giving rise to such indemnification obligation.

                  (f) Upon the issuance of Option Shares hereunder,  the Company
shall  promptly list such Option  Shares with the New York Stock  Exchange or on
such national or other  exchange on which the shares of Company Common Stock are
at the time principally listed.

         10. Extension of Time for Regulatory Approvals.  The periods related to
exercise  of the  Option  and the other  rights of  Grantee  hereunder  shall be
extended (a) to the extent necessary to obtain all regulatory  approvals for the
exercise of such rights, and for the expiration of all statutory waiting periods
and (b) to the extent  necessary to avoid  liability  under Section 10(b) of the
Exchange Act by reason of such exercise.

         11.  Representations and Warranties of the Company.  The Company hereby
represents and warrants to Grantee as follows:

                  (a) Authority.  The Company has the necessary  corporate power
and authority to enter into this Agreement, to perform its obligations hereunder
and to  consummate  the  transactions  contemplated  hereby.  The  execution and
delivery of this Agreement by the Company and the consummation by the Company of
the transactions  contemplated  hereby have been duly and validly  authorized by
all necessary corporate action and no other corporate proceedings on the part of
the Company are  necessary to authorize  this  Agreement  or to  consummate  the
transactions  contemplated  hereby.  This  Agreement  has been duly executed and
delivered by the Company  and,  assuming the due  authorization,  execution  and
delivery by Grantee,  constitutes a legal,  valid and binding  obligation of the
Company, enforceable in accordance with its terms, except as such enforceability
may be limited by bankruptcy, insolvency,  reorganization,  moratorium and other
similar laws of general applicability relating to or affecting creditors' rights
generally and by the application of general principles of equity.

                  (b)  Corporate  Action.  The Company  has taken all  necessary
corporate  action to  authorize  and reserve and to permit the Company to issue,
and at all times from the date hereof through the  termination of this Agreement
in  accordance  with its terms will have reserved for issuance upon the exercise
of the  Option,  that  number of shares of  Company  Common  Stock  equal to the
maximum  number of shares of Company  Common  Stock at any time and from time to
time  issuable  hereunder,  and all such shares of Company  Common  Stock,  upon
issuance pursuant hereto, will be duly authorized,  validly issued,  fully paid,
non-assessable, and will be delivered free and clear of all Encumbrances and not
subject to any preemptive rights.

                  (c) No Conflict.  The execution and delivery of this Agreement
by the Company do not,  and the  performance  by the Company of its  obligations
under this  Agreement  will not (i) conflict with or violate the  certificate or
articles of incorporation, bylaws or partnership agreement of the Company or any
Company Subsidiary,  (ii) conflict with or violate any law, statute,  ordinance,
rule,  regulation,  order,  judgment or decree  applicable to the Company or any
Company  Subsidiary or by which any of their  respective  properties is bound or
affected,  or (iii) result in any breach of or constitute a default (or an event
which  with or without  notice or lapse of time or both would  become a default)
under, or give to others any rights of termination,  amendment,  acceleration or
cancellation  of, or  result in the  creation  of an  Encumbrance  on any of the
properties or assets of the Company or any Company  Subsidiary  pursuant to, any
note, bond, mortgage,  indenture,  contract,  agreement, lease, license, permit,
franchise or other  instrument or obligation to which the Company or any Company
Subsidiary is a party or by which the Company,  any Company Subsidiary or any of
their respective properties or assets is bound or affected,  except, in the case
of clauses (ii) and (iii) above, for any such conflicts,  violations,  breaches,
defaults  or other  alterations  or  occurrences  that would not have a Material
Adverse Effect on the Company.

                  (d) Anti-Takeover  Statutes.  The provisions of Section 203 of
the  General  Corporation  Law of the State of Delaware  will not,  prior to the
termination  of this  Agreement,  apply to this  Agreement  or the  transactions
contemplated  hereby and thereby.  The Company has taken, and will in the future
take, all steps necessary to irrevocably exempt the transactions contemplated by
this  Agreement  from  any  other  applicable  state  takeover  law and from any
applicable  charter  provision  containing  change of control  or  anti-takeover
provisions.

                  (e)   Additional    Representations   and   Warranties.    The
representations and warranties  contained in Section 3.1 of the Merger Agreement
and,  to the extent  they  relate to this  Agreement,  the  representations  and
warranties  in  Section  3.3,  Section  3.20,  and  Section  3.26 of the  Merger
Agreement, are incorporated by reference herein.

         12. Assignment.  The Company may not assign any of the Company's rights
or obligations under this Agreement or the Option created hereunder to any other
Person, without the express written consent of Grantee.

         13.  Application  for  Regulatory  Approval.  Each of  Grantee  and the
Company will use its reasonable  efforts to make all filings with, and to obtain
consents  of, all third  parties  and  Governmental  Entities  necessary  to the
consummation  of the  transactions  contemplated  by this  Agreement,  including
without limitation making application to list the shares of Company Common Stock
issuable  hereunder  on the New York  Stock  Exchange  upon  official  notice of
issuance.

         14.  Specific  Performance.  The Company  acknowledges  and agrees that
damages  would be an  inadequate  remedy for a breach of this  Agreement  by the
Company and that the  obligations of the Company shall be enforceable by Grantee
through injunctive or other equitable relief.

         15.  Severability.  If any term or other provision of this Agreement is
invalid,  illegal or  incapable  of being  enforced by any rule of law or public
policy, all other conditions and provisions of this Agreement shall nevertheless
remain in full force and effect so long as the  economic or legal  substance  of
the transactions  contemplated  hereby is not affected in any manner  materially
adverse to any party. Upon such  determination  that any term or other provision
is invalid,  illegal or incapable of being  enforced,  the parties  hereto shall
negotiate  in good faith to modify this  Agreement  so as to effect the original
intent of the parties as closely as possible in an acceptable  manner to the end
that transactions contemplated hereby are fulfilled to the extent possible.

         16.  Notices.  All notices,  claims,  demands and other  communications
hereunder  shall be deemed to have been  duly  given or made when  delivered  in
person,  by  registered  or certified  mail  (postage  prepaid,  return  receipt
requested),  by overnight courier or by facsimile at the respective addresses of
the parties set forth in the Merger Agreement.

         17. Governing Law. This Agreement shall be governed by and construed in
accordance  with the laws of the State of Delaware,  regardless of the laws that
might otherwise govern under applicable principles of conflicts of laws thereof.

         18.  Counterparts.  This Agreement may be executed and delivered in one
or  more  counterparts,   and  by  the  different  parties  hereto  in  separate
counterparts, each of which when executed and delivered shall be deemed to be an
original  but all of which  taken  together  shall  constitute  one and the same
agreement.

         19.  Definitions.  Capitalized  terms used and not defined herein shall
have the meanings set forth in the Merger Agreement.

         20. Expenses.  Except as otherwise  expressly provided herein or in the
Merger  Agreement,  each of the parties  hereto shall bear and pay all costs and
expenses  incurred by it or on its behalf in  connection  with the  transactions
contemplated  hereunder,  including  fees  and  expenses  of its  own  financial
consultants, investment bankers, accountants and counsel.

         21.  Entire  Agreement.  This  Agreement,  the  Merger  Agreement,  the
Confidentiality  Agreement and any documents and instruments  referred to herein
and therein  constitute the entire  agreement of the parties with respect to the
transactions  contemplated  hereunder and supersede  all prior  arrangements  or
understandings  with respect thereof,  written or oral. The terms and conditions
of this Agreement  shall inure to the benefit of and be binding upon the parties
hereto and their respective  successors and permitted  assigns.  Nothing in this
Agreement,  express or implied, is intended to confer upon any party, other than
the parties hereto, and their respective  successors and permitted assigns,  any
rights,  remedies,  obligations  or  liabilities  under  or by  reason  of  this
Agreement,  except as expressly provided herein. Any provision of this Agreement
may be waived  only in writing at any time by the party that is  entitled to the
benefits of such provision. This Agreement may not be modified, amended, altered
or  supplemented  except upon the execution and delivery of a written  agreement
executed by the parties hereto.

         22. Further  Assurances.  In the event of any exercise of the Option by
Grantee,  the Company and Grantee shall execute and deliver all other  documents
and  instruments  and take all other action that may be reasonably  necessary to
the fullest  extent  permitted by law in order to  consummate  the  transactions
provided for by such  exercise.  Nothing  contained in this  Agreement  shall be
deemed to authorize the Company or Grantee to breach any provision of the Merger
Agreement.


             [The remainder of this page intentionally left blank.]


<PAGE>

                  IN WITNESS WHEREOF, each of the parties hereto has caused this
Stock  Option  Agreement  to be executed as of the date first  written  above by
their respective officers thereunto duly authorized.


                                      MEDCO RESEARCH, INC.


                                      By: /s/ Richard C. Williams
                                         -------------------------------
                                      Name:  Richard C. Williams
                                      Title:     Chairman



                                      KING PHARMACEUTICALS, INC.


                                      By: /s/ John M. Gregory
                                         -------------------------------
                                      Name:  John M. Gregory
                                      Title:     Chairman of the Board &
                                                 Chief Executive Officer




FOR IMMEDIATE RELEASE
Contacts:
Glenn C. Andrews
Executive Vice President or
Mike Freeman
Director, Corporate Communications
Medco Research, Inc.
(919) 653-7001

                        MEDCO RESEARCH TO BE ACQUIRED BY
                              KING PHARMACEUTICALS

RESEARCH TRIANGLE PARK, NC, December 1, 1999 - Medco Research,  Inc.  (NYSE:MRE)
today  announced  that its Board of Directors  has approved the  acquisition  of
Medco Research by King Pharmaceuticals,  Inc.  (NASDAQ:KING).  King will acquire
Medco Research in an all-stock,  tax-free pooling of interests transaction.  The
transaction is subject to the approval of Medco Research's shareholders.

The equity value of the transaction is approximately $350 million, or $31.45 per
Medco Research  share,  based on King's November 30, 1999 closing stock price of
$46.13 per share and Medco  Research's 11.0 million fully diluted shares.  Under
the terms of the  agreement,  which has been approved by the boards of directors
of both  companies,  holders of Medco Research  common stock will be entitled to
receive a certain  number of shares of King common  stock in exchange for shares
of Medco Research common stock.  The terms of the agreement fix the common stock
exchange  ratio at 0.6818  shares of King  common  stock for each share of Medco
Research  common stock,  provided that the average  closing price of King common
stock  during the twenty (20)  consecutive  trading days ending on the third day
preceding Medco Research's  shareholder meeting is between $33.00 and $49.87 per
share.  If the average  closing  price of King common  stock is above $49.87 per
share,  King will deliver the number of shares of King common stock to provide a
purchase  price of  $34.00  per share of Medco  Research  common  stock.  If the
average closing price of King common stock is below $33.00 per share,  King will
deliver the number of shares of King common stock to provide a purchase price of
$22.50 per share of Medco Research  common stock.  King may elect not to proceed
with the  transaction  if the average  closing  price of King common stock falls
below $30.00 per share.  The agreement  includes  certain  provisions that would
enable King to acquire up to 19.9% of Medco Research's  common stock and receive
certain termination fees in the event the transaction is not consummated.

King  Pharmaceuticals,   headquartered  in  Bristol,  Tennessee,   manufactures,
markets,  sells, and distributes  primarily branded prescription  pharmaceutical
products.  The  Company  has built a  successful  business  by  capitalizing  on
opportunities  to  acquire  branded  pharmaceutical  products  and  subsequently
increasing  their sales by focused  promotion and marketing,  the development of
product  line  extensions,   and  product  life  cycle  management.   Since  its
incorporation  in 1993, King has acquired more than 35 products which it markets
by means of a national sales force of over 250 sales representatives. Recognized
brand  name  prescription  products  owned  by the  Company  include  Altace(R),
Lorabid(R), Neosporin(R), Cortisporin(R), Pitocin(R), and Fluogen(R).

The  combining  of the two  companies  provides  for the  acceleration  of Medco
Research's  stated  strategy  of forward  integrating  its  business in order to
improve  margins and realize a greater return on  investment.  King provides the
marketing  and sales  organization  necessary to  capitalize  on the  commercial
potential of the Company's portfolio of adenosine  receptor-based  technologies.
Medco Research provides King with a research and development  organization and a
technology  platform that will serve as an in-house pipeline of new products and
as a complement to the company's ongoing product acquisition activities.

Based upon an assessment of a number of factors as part of the transition of the
Company  from a stand alone entity to its new role as the  development  arm of a
fully integrated  pharmaceutical company,  research and development resources of
the combined  companies will be directed  toward  expediting the  development of
MRE0470  and a number of lead  preclinical  programs  from  among the  Company's
pipeline of over 150 unique, proprietary  adenosine-receptor  analogs. Plans are
underway to outlicense  Pallacor(TM),  the Company's  formulation of intravenous
adenosine  for  use in  combination  with  thrombolysis  or  angioplasty  in the
treatment of acute myocardial infarction, for commercialization.

Commenting on the merger  agreement,  Richard C. Williams,  Chairman of Board of
Medco  Research,  stated,  " We are  indeed  pleased  to  have  entered  into an
agreement  with  King  Pharmaceuticals.  It is not  only an  excellent  business
combination  from  a  strategic  standpoint,  but a  superb  integration  of two
organizations  with  similar  corporate  cultures.  In  our  dealings  with  the
management of King, I am pleased with their high regard for the value of people,
business philosophy and high level of integrity.  Medco Research's employees and
all other assets will integrate into the King  operation.  This proposed  merger
will be  beneficial to all parties in that it provides the  opportunity  for the
combined entity to be a more fully integrated pharmaceutical company - a goal of
both  of  us.  The  therapeutic  consistency  of  the  two  companies  -  King's
cardiovascular   commercial   presence  and  Medco   Research's   cardiovascular
development  capability - provides a formidable  core  business for the combined
entity. Medco Research's portfolio, earnings level, cash and cash flow will help
strengthen the market value and financial  prospects of the combined  entity.  I
believe that King can build on the  strengths of Medco  Research and fulfill our
joint  mission of being a leader in  commercialization  of  products  leading to
superior growth in shareholder value."

Glenn C. Andrews, Executive Vice President, Finance and Administration and Chief
Financial  Officer,  Medco Research,  stated "The merger of these two successful
companies  is  a  textbook  example  of  synergy.  The  compatibility  of  Medco
Research's  personnel  and product  development  expertise  with King's  forward
integrated  operations  effectively  minimizes the  redundancy and maximizes the
economic efficiencies of this strategic integration.  The combined company, with
a market capitalization well in excess of $2 billion,  should be very successful
in attracting and securing strong  institutional and retail  ownership.  We look
forward to King realizing the commercial potential of the Company's portfolio of
adenosine receptor-based technologies in the coming years."

Hambrecht  &  Quist  LLC  acted  as  financial  advisor  to the  Company  on the
transaction.

A  conference  call  regarding  the  acquisition  is  scheduled  for 11:00 a.m.,
Wednesday,  December  1,  1999.  Interested  parties  may  listen to the call by
dialing 1-888  715-0381  (U.S.) or 973 633-1010  (outside  U.S.) A replay of the
call  will be  available  for two  weeks  following  the call by  dialing  1-888
459-5780 (U.S.) or 402 220-1159 (outside U.S.)

Statements  contained in this release which are not historical  facts are or may
constitute  forward looking  statements under the safe harbor  provisions of the
Private Securities  Litigation Reform Act of 1995. Although the Company believes
the  expectations  reflected in such forward  looking  statements are based upon
reasonable  assumptions,  it can give no assurance that its expectations will be
attained.  Forward-looking statements involve known and unknown risks that could
cause the Company's actual results to differ  materially from expected  results.
Factors  that could cause actual  results to differ  materially  include,  among
others,  assimilation  and other  risks  related to  mergers;  the high cost and
uncertainty of the research,  clinical trials and other  development  activities
involving  pharmaceutical products; the Company's ability to fund its activities
internally or through additional financing,  if necessary;  the unpredictability
of the  duration and results of the U.S.  FDA's review of New Drug  Applications
and  Investigational New Drug Applications and/or the review of other regulatory
agencies  worldwide;  the  possible  impairment  of,  or  inability  to  obtain,
intellectual  property  rights and the cost of obtaining  such rights from third
parties;  intense competition;  the uncertainty of obtaining,  and the Company's
dependence on third  parties to  manufacture  and sell its products;  results of
pending or future  litigation and other risk factors  detailed from time to time
in the Company's SEC filings.  The Company does not undertake to publicly update
or revise any of its forward  looking  statements  even if  experience or future
changes show that the indicated results or events will not be realized.

                                      ####

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