MEDCO RESEARCH INC
10-Q, 1999-08-13
PHARMACEUTICAL PREPARATIONS
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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549
                                    FORM 10-Q

[X] Quarterly Report Pursuant to Section 13 or 15 (d) of the Securities Exchange
Act of 1934 For the quarterly period ended June 30, 1999

                                       OR

[ ] Transition Report Pursuant to Section 13 or 15(d) of the Securities Exchange
Act of 1934 Commission file number 1-9771

                              MEDCO RESEARCH, INC.
             (Exact name of registrant as specified in its charter)

        Delaware                                             95-3318451
- -------------------------------                       -------------------------
(State or other Jurisdiction of                      (I.R.S. Identification No.)
  Employer incorporation or
            organization)

 7001 Weston Parkway, Suite 300,
 Cary, North Carolina                                         27513
 ----------------------------                            --------------
 (Address of principal executive offices)                  (Zip Code)

                                 (919) 653-7001
                                 --------------
              (Registrant's telephone number, including area code)

           Securities registered pursuant to Section 12(b)of the Act:

 Common Stock together with associated
    Common Stock Purchase Rights                      New York Stock Exchange
- --------------------------------------             --------------------------
          (Title of Class)                      (Name of each exchange on which
                                                            registered)

           Securities registered pursuant to Section 12(g) of the Act:

                                      None

         Indicate by check mark whether the registrant (1) has filed all reports
required to be filed by Section 13 or 15 (b) of the  Securities  Exchange Act of
1934  during  the  preceding  12 months  (or for such  shorter  period  that the
registrant was required to file such reports),  and (2) has been subject to such
filing requirements for the past 90 days.

YES    X       NO
   -------       -------

         Indicate the number of shares  outstanding  of common stock,  as of the
latest practical date 10,338,145 as of July 21, 1999.
         Pursuant to the Securities  Exchange Act of 1934 Release 15502 and Rule
240.03 (b), the pages of this  document  have been  numbered  sequentially.  The
total pages contained herein are 15.

                                       1
<PAGE>
<TABLE>
<CAPTION>


                              Medco Research, Inc.
                         PART I - FINANCIAL INFORMATION
Item 1. Financial Statements
                           Consolidated Balance Sheets

                                                                                    JUNE 30,                   December 31,
                                                                                      1999                        1998*
                                                                                ----------------------------------------------------
   (in thousands except share data)                                               (UNAUDITED)
<S>         <C>
ASSETS
Current assets:
   Cash and cash equivalents                                                            $ 3,434                    $ 4,742
   Investments held to maturity                                                          18,555                     21,434
   Accounts and notes receivable:
     Royalties                                                                            9,436                      8,349
     Other                                                                                   71                         85
   Accrued interest income                                                                  730                        578
   Prepaid expenses and other                                                               519                        243
   Deferred tax asset - current portion                                                     458                        458
                                                                                ----------------------------------------------------
Total current assets                                                                     33,203                     35,889
Investments held to maturity                                                             31,054                     25,074
Property and equipment, at cost, net of accumulated depreciation and
   amortization                                                                             654                        465
Patent, trademark and distribution rights, at cost, net of accumulated
   amortization                                                                           1,322                      1,629
Deferred tax asset                                                                        1,228                      1,228
                                                                                ----------------------------------------------------
Total assets                                                                            $67,461                    $64,285
                                                                                ====================================================
LIABILITIES AND STOCKHOLDERS' EQUITY Current liabilities:
   Accounts payable and accrued expenses                                                 $3,575                    $ 3,401
   Accrued royalties                                                                      2,521                      2,166
   Accrued compensation                                                                     283                        509
                                                                                ----------------------------------------------------
Total current liabilities                                                                 6,379                      6,076
   Other long-term liabilities                                                               50                        150
                                                                                ----------------------------------------------------
Total liabilities                                                                         6,429                      6,226
Stockholders' equity
   Common stock, no par value, authorized 40,000,000 shares; shares issued of
     11,412,445 and 11,298,732 at June 30, 1999 and December 31, 1998,
     respectively; shares outstanding of 10,338,145 and 10,409,332 at June 30,
     1999 and December 31, 1998, respectively
                                                                                         55,131                     53,806
   Retained earnings                                                                     21,165                     15,061
   Cost of stock held in treasury, 1,074,300 and 889,400 shares at June
     30, 1999 and December 31, 1998, respectively                                       (15,264)
                                                                                                                   (10,808)
                                                                                ----------------------------------------------------
Total stockholders' equity                                                               61,032                     58,059
                                                                                ----------------------------------------------------
Commitments and contingencies

                                                                                ====================================================
Total liabilities and stockholders' equity                                              $67,461                    $64,285
                                                                                ====================================================

</TABLE>

See accompanying notes to consolidated financial statements.
*Abstracted from audited year-end financial statements.

                                       2

<PAGE>


                              Medco Research, Inc.
                      Consolidated Statements of Operations
                                   (Unaudited)
<TABLE>
<CAPTION>


                                                                         THREE MONTHS ENDED                   SIX MONTHS ENDED
                                                                -------------------------------------------------------------------
                                                                     JUNE 30,            June 30,         JUNE 30,         June 30,
(in thousands, except per share data)                                  1999                1998             1999             1998
                                                                -------------------------------------------------------------------
<S> <C>


Royalty revenue                                                        $8,936             $6,387          $16,502          $12,766
 Royalty expense                                                        1,579                919            2,908            2,183
                                                                -------------------------------------------------------------------
   Gross margin                                                         7,357              5,468           13,594           10,583
                                                                -------------------------------------------------------------------

Operating expenses:
   Research & development costs                                         2,344              3,836            4,352            5,564
   General and administrative expenses                                    803                572            1,531            1,197
                                                                -------------------------------------------------------------------
                                                                        3,147              4,408            5,883            6,761
                                                                -------------------------------------------------------------------

Operating income                                                        4,210              1,060            7,711            3,822

Other income:
   Interest income                                                        746                659            1,471            1,273
   Other income                                                             -              4,000                -            4,000
                                                                -------------------------------------------------------------------

Income before taxes                                                     4,956              5,719            9,182            9,095

Provision for income taxes                                              1,663                497            3,078              702
                                                                -------------------------------------------------------------------

Net income                                                            $ 3,293            $ 5,222          $ 6,104          $ 8,393
                                                                ===================================================================

Basic earnings per share                                              $  0.32            $  0.49          $  0.59          $  0.80
                                                                ===================================================================

Diluted earnings per share                                            $  0.31            $  0.48          $  0.57          $  0.77
                                                                ===================================================================

Weighted average shares outstanding                                    10,332             10,558           10,346           10,538
                                                                ===================================================================

Net effect of dilutive stock options based on treasury stock
   method using average market price                                      389                407              403              324
                                                                ===================================================================

Weighted average shares outstanding
   Assuming dilution                                                   10,721             10,965           10,749           10,862
                                                                ===================================================================

</TABLE>


See accompanying notes to consolidated financial statements.

                                       3
<PAGE>


                              Medco Research, Inc.
                 Consolidated Statements of Stockholders' Equity
                                   (Unaudited)


                         SIX Months Ended JUNE 30, 1999


(in thousands)
<TABLE>
<CAPTION>

                                           Common Stock
                               ------------------------------------
                                                                                               Cost of
                                    Number of                            Retained            stock held
                                      shares         Amount              Earnings            in treasury           Total
                               -----------------------------------------------------------------------------------------------
<S>         <C>
Balance at
   December 31, 1998                  10,409          $53,806             $15,061            $(10,808)           $58,059

Stock options
 exercised                                74              785                   -                   -                785

Stock warrants
   exercised                              40              540                   -                   -                540

Purchase of stock
 held in treasury                       (185)               -                   -              (4,456)            (4,456)

Net income                                 -                -               6,104                   -              6,104

                               -----------------------------------------------------------------------------------------------
BALANCE AT
    JUNE 30, 1999                     10,338          $55,131             $21,165            $(15,264)           $61,032
                               ===============================================================================================

</TABLE>


See accompanying notes to consolidated financial statements.

                                       4
<PAGE>


                              Medco Research, Inc.
                      Consolidated Statements of Cash Flows
                                   (Unaudited)
<TABLE>
<CAPTION>


                                                                           SIX MONTHS ENDED
                                                             --------------------------------------------
                                                                    JUNE 30,              June 30,
                                                                      1999                  1998
                                                             --------------------------------------------
(in thousands)
<S>        <C>
OPERATING ACTIVITIES:
Net income                                                         $6,104                $8,393
Adjustments to reconcile net income to net cash provided
   by operating activities:
     Depreciation of property and equipment                            86                    48
     Amortization of patent, trademark and distribution
       rights                                                         307                   298
     Net amortization of investment discount                         (101)                 (199)
     Changes in operating assets and liabilities:
         Accounts receivable                                       (1,073)                 (259)
         Prepaid expenses                                            (276)                 (175)
         Accounts payable and accrued expenses                       (152)                 (464)
         Accrued royalty expense                                      355                   412
         Accrued interest income                                     (152)                   90
         Deferred tax asset                                             -                   321
         Deferred royalty payments                                      -                  (730)
                                                             ---------------------------------------------

Net cash provided by operating activities                          $5,098                $7,735
                                                             ---------------------------------------------

</TABLE>



(Continued)

                                       5

<PAGE>


                              Medco Research, Inc.
                      Consolidated Statements of Cash Flows
                                   (Unaudited)
<TABLE>
<CAPTION>


                                                                          SIX MONTHS ENDED
                                                             -------------------------------------------
                                                                    JUNE 30,             June 30,
                                                                      1999                 1998
                                                             -------------------------------------------
<S>       <C>
(in thousands)

INVESTING ACTIVITIES:
Purchase of investments held to maturity                                 (16,000)             (15,939)
Maturity of investments held to maturity                                  13,000               13,422
Purchases of property and equipment                                         (275)                   -
Purchases of patents                                                           -                 (713)
                                                             -------------------------------------------
Net cash provided by (used in) investing activities
                                                                          (3,275)              (3,230)
                                                             -------------------------------------------
FINANCING ACTIVITIES:
Proceeds from exercise of options                                            785                  635
Proceeds from exercise of warrants                                           540                    -
Purchase of stock held in treasury                                        (4,456)                   -
                                                             -------------------------------------------
Net cash (used in) financing activities
                                                                          (3,131)                 635
                                                             -------------------------------------------
Increase (decrease) in cash and cash equivalents                          (1,308)               5,140
Cash and cash equivalents at beginning of period
                                                                           4,742                2,726
                                                             -------------------------------------------
Cash and cash equivalents at end of period
                                                                          $3,434               $7,866
                                                             ===========================================

</TABLE>

See accompanying notes to consolidated financial statements.

                                       6
<PAGE>


                              Medco Research, Inc.
              NOTES TO UNAUDITED CONSOLIDATED FINANCIAL STATEMENTS
              ----------------------------------------------------

GENERAL

The  accompanying  interim  financial  statements  have been  prepared  by Medco
Research,  Inc. (the "Company") in accordance with generally accepted accounting
principles.  Certain disclosures and information  normally included in financial
statements  have been condensed or omitted.  In the opinion of the management of
the  Company,  these  financial  statements  contain all  adjustments  (all of a
recurring  nature)  necessary for a fair  presentation  for the interim periods.
These statements should be read in conjunction with the financial statements and
notes  included in the  Company's  Annual Report on Form 10-K for the year ended
December 31, 1998.

CASH AND CASH EQUIVALENTS

The Company  considers  all highly liquid  investments  with a maturity of three
months or less when purchased to be cash equivalents.

ADOPTION OF NEW ACCOUNTING PRONOUNCEMENTS

The  Company  adopted  Statement  of  Financial  Accounting  Standards  No.  130
"Reporting  Comprehensive  Income"  ("SFAS No.  130") for its fiscal year ending
December  31,  1998.  SFAS No.  130  requires  the  Company to display an amount
representing  the total  comprehensive  income  for the  period  in a  financial
statement  which  is  displayed  with  the same  prominence  as other  financial
statements. The Company has no items of other comprehensive income in any period
presented and therefore is not required to report comprehensive income.

The Company  will adopt  Statement  of Financial  Accounting  Standards  No. 133
"Accounting for Derivative  Investments and Hedging Activities" ("SFAS No. 133")
for its fiscal year ending  December 31, 2000.  SFAS No. 133  establishes  a new
model for accounting for derivatives  and hedging  activities and supersedes and
amends a number of existing  standards.  The adoption of this  pronouncement  is
expected to have no impact on the  Company's  results of operations or financial
condition.

CONTRACTS

In May 1999, the Company  terminated a Clinical Study  Agreement with ClinTrials
Research,  Inc. The parties are in the process of negotiating  the amount of the
final payment due to ClinTrials  Research under the  agreement.  The Company has
accrued its best  estimate of the amount of such final  payment at June 30, 1999
and does not believe  that any  payment  required  will have a material  adverse
affect on its financial condition or results of operations.

CONTINGENCY

There are no legal proceedings pending against the Company.  However, on October
3, 1997, Richard A. Wilson, Debra A. Angello, and Paul S. Angello ("Plaintiffs")
filed a complaint against Fujisawa,  USA, Inc. ("Fujisawa") in the United States

                                       7
<PAGE>

District Court,  District of Oregon,  alleging that Fujisawa's sale of Adenoscan
in the United States induces, or contributes to, the infringement of plaintiffs'
U.S. Patent No.  4,824,660 ("the `660 patent"),  entitled "Method of Determining
the Viability of Tissue in an Organism"  which the Patent Office issued on April
25, 1989.  According to plaintiffs,  the `660 patent claims a specific technique
for more reliably locating viable or nonviable  regions of heart tissue,  namely
using an adenosine  triphosphate  repleting agent such as ribose or adenosine as
an adjunct to radioactive  isotope  (e.g.,  thallium-201)  myocardial  perfusion
scintigraphy,  where  regions of heart  tissue in which the scan  images show no
radioactivity indicate the presence of nonviable heart tissue. In its Answer and
Counterclaim,  Fujisawa  denied that it infringed  any of the claims of the `660
patent and alleged that the `660 patent was invalid.  Fujisawa  further  alleged
that plaintiffs'  claims of patent  infringement were barred by the doctrines of
laches and  estoppel.  In its  Counterclaim,  Fujisawa  requested a  declaratory
judgment  that it did not  infringe  the claims of the `660 patent and that such
patent is invalid.

An  agreement  in  principle  has been  reached  to end this  litigation,  which
agreement  is subject to the approval of the Boards of Directors of Fujisawa and
the Company.  Under the agreement in principle,  the plaintiffs  agreed to grant
Fujisawa a license  under the `660  patent.  The Company  does not believe  that
payment of its share of the fixed license fees payable over the  remaining  life
of the `660 patent by Fujisawa to the plaintiffs  will have any material  affect
on the Company's financial condition or results of operations. The license would
be royalty-free.


Item 2. Management's Discussion and Analysis of Financial Condition and Results
         of Operations


RESULTS OF OPERATIONS
- ---------------------

Second Quarter and Six Months of 1999 Compared to Second Quarter and Six Months
 of 1998

Net Revenues.  The Company's second quarter and first six months of 1999 royalty
revenues increased to $8.936 million and $16.502 million from $6.387 million and
$12.766  million,  an increase  of 40% and 29%  respectively,  due to  continued
year-over-year  increases in unit sales of Adenoscan by Fujisawa,  the Company's
North American licensee. Substantially all of the royalty revenue of the Company
is  generated  by  Fujisawa  Healthcare,  Inc.  ("Fujisawa")  from its  sales of
Adenoscan and Adenocard in the United States and Canada.

Gross Margin.  The Company's  second  quarter and first six months of 1999 gross
margin from adenosine  revenues  increased to $7.357 million and $13.594 million
from  $5.468  million  and  $10.583   million,   an  increase  of  35%  and  28%
respectively,  due to an increase in the Company's  second quarter and first six
months of 1999 royalty revenues of 40% and 29% respectively. Royalty expense for
the second quarter and first six months from adenosine sales increased to $1.579
million and $2.908 million from $.919 million and $2.183 million, an increase of
72% and 33%  respectively,  primarily due to a 116%  increase in second  quarter
1999 net sales of  Adenocard,  a drug for which the  Company  pays a royalty  of
12.5% of net sales to the University of Virginia Alumni Patents Foundation.

                                       8
<PAGE>

Operating  Expenses.  The Company's  second quarter and first six months of 1999
total  operating  expenses  decreased to $3.147  million and $5.883 million from
$4.408  million  and $6.761  million,  a decrease  of 29% and 13%  respectively.
Research and development  ("R&D")  expenditures  decreased to $2.344 million and
$4.352 million from $3.836 million and $5.564 million in 1998, a decrease of 39%
and 22%, due to a one-time charge of $2.361 million to R&D in the second quarter
of 1998 for the  purchase  of  Fujisawa's  commercialization  rights and related
intellectual  properties  for the  cardioprotection  application  of intravenous
adenosine offset by increased  expenditures in 1999 related to the initiation of
AMISTAD II, a phase III study to further  investigate the safety and efficacy of
PallacorTM,  as well as, the  initiation  and  completion  of a phase I study of
MRE0470,  a selective coronary  vasodilator during myocardial  perfusion imaging
procedures  to diagnose  coronary  artery  disease.  General and  administrative
expenditures  for second  quarter and the first six months of 1999  increased to
$.803  million and $1.531  million  from $.572  million and $1.197  million,  an
increase of 40% and 28%, due to a one-time North Carolina  franchise tax benefit
included  in second  quarter  1998 of  $100,000  and an  increase in expenses in
second quarter 1999 related to the completion of a compensation study, increased
investor  relations  expenses and expenses  related to the Company's move to new
office space.

Other  Income.  Interest  income for the second  quarter and first six months of
1999 increased 13% and 16% over the comparable  periods in 1998 primarily due to
higher  investment  balances.  Other income for second  quarter,  as well as the
first six  months of 1999  decreased  $4  million  as a result of the  Company's
receipt of a $4 million  payment in second  quarter  1998 from  Fujisawa for the
assistance  provided by the Company to Fujisawa in connection  with the contract
manufacturing  of Adenoscan  and  Adenocard by a third party and the transfer of
the Adenoscan and Adenocard NDAs to Fujisawa.

Provision For Income Taxes. The Company  recognized tax expense at a rate of 34%
during the second  quarter  and first six months of 1999 versus 9% and 8% in the
second  quarter  and first six months of 1998 as a result of the  Company  fully
utilizing its income tax net operating loss  carryforward  in the fourth quarter
of 1998.

Earnings  Per Share.  In the second  quarter  and first six months of 1999,  the
Company had net income of $3.293  million and $6.104  million or $0.31 and $0.57
diluted  earnings  per share  compared to $5.222  million and $8.393  million or
$0.48 and $0.77 diluted earnings per share for the year earlier period. Weighted
average  common  shares  and common  share  equivalents  outstanding  for second
quarter and the first six months of 1999 were 10.721 million and 10.749 million,
respectively,  versus  10.965  million  and 10.862  million  for the  comparable
periods of the prior  year.  This  apparent  decline in  earnings  is due to the
non-recurring increase in income in the second quarter of 1998 of $1.639 million
and the  Company  recognizing  tax  expense  at a rate of 34%  during the second
quarter and first six months of 1999 versus 9% and 8% in the second  quarter and
first six months of 1998 as a result of the Company  fully  utilizing its income
tax net  operating  loss  carryforward  in the fourth  quarter of 1998. On a pro
forma basis,  excluding the  non-recurring  increase in income and assuming that
the Company had fully utilized its net operating loss carryforward  prior to the
first  quarter of 1998,  diluted  earnings per share for the second  quarter and
first six months of 1998 would  have been $0.25 and $0.46  respectively.  Second
quarter and first six months  earnings per share  increased  24% compared to the
second quarter and first six months of 1998 on a pro forma basis.

                                       9
<PAGE>

LIQUIDITY AND CAPITAL RESOURCES
- -------------------------------

As of June 30,  1999,  the  Company  had total cash and  investments  of $53.043
million  comprised of $3.434  million of cash and cash  equivalents  and $49.609
million of  investments  in U.S.  Treasury  Notes,  debt  securities  of various
federal governmental agencies,  and high quality corporate debt securities.  The
Company's  working capital as of June 30, 1999 was $26.824 million,  compared to
$29.813 million as of December 31, 1998.

The Company will not generate  revenues from its other products unless and until
it or its licensees  receive  marketing  clearance from the FDA and  appropriate
governmental agencies in other countries.  The Company cannot predict the timing
of any potential marketing clearance nor can assurances be given that the FDA or
such agencies will approve any of the Company's products.  For the near term the
Company expects to receive  substantially all of its royalty revenues from sales
of its products in the U.S. by Fujisawa Healthcare, Inc.


IMPACT OF INFLATION
- -------------------

Although  it is  difficult  to  predict  the  impact of  inflation  on costs and
revenues of the Company in connection with the Company's  products,  the Company
does not anticipate that inflation will materially impact its costs of operation
or the profitability of its products when marketed.


IMPACT OF YEAR 2000

Readiness
- ---------
The Year 2000 ("Y2K")  issue results from  programmers  using only two digits to
indicate the century,  decade and year in date fields.  This  generally  affects
older software and embedded  systems of the Company and third parties with which
it does business,  thereby threatening operations and the existence and validity
of data. The team that the Company  assembled to address the Y2K issue brings to
bear  knowledge  from all areas of the Company and helps  minimize the potential
impact to the Company.

The Company has  categorized the Y2K issue into three parts:  internal  business
systems software; internal non-business  software/embedded systems; and external
vendors. The Company's reliance on an outsourcing  philosophy,  which encourages
the use of partnering  agreements with third parties to accomplish many business
functions,  eases the Y2K issue as the Company  does not have a large  number of
internal business systems applications or embedded systems.  However, given that
the Company  receives  substantially  all of its royalty  revenues from Fujisawa
Healthcare,  Inc.,  the Y2K  issue  is still a threat  and is being  given  full
attention by the Company,  especially  in assessing  the  Company's  third party
relationships.
                                       10
<PAGE>


Internal Business Systems
- -------------------------
The  Company  does not  rely on  custom  developed  solutions  for its  business
systems.  The software that it uses is mass-produced  and has been  inventoried.
The  providers  have  advised  the Company  that it has been made Y2K  compliant
through normal manufacturer  upgrades and updates to the software.  Accordingly,
all software and  hardware is either Y2K  compliant or has been  replaced in the
normal course of business.

Internal Non-Business Software/Embedded Systems
- -----------------------------------------------
All internal  non-business  software and embedded systems have been inventoried.
The  providers  have been queried  regarding  Y2K  compliance.  At this time all
software  and  systems  are either Y2K  compliant  or have been  replaced in the
normal course of business.

External Vendors
- ----------------
A database has been  established  to track  progress the  Company's  vendors are
making in becoming Y2K compliant. The Company has closely monitored the progress
and  potential  impact of  vendors  that may fail to  become  Y2K  compliant  by
year-end  1999.  The Company has submitted  questionnaires  to its licensees and
material vendors, including Fujisawa, relative to their Y2K compliance. To date,
Fujisawa  represents  that it has completed  replacement  of  non-compliant  web
server  equipment and operating  systems and  installation of a compliant system
for trading with outside  customers.  Fujisawa has completed  replacement of its
servers and upgrade of its operating systems including  business system hardware
and software.  Fujisawa  expects to complete  upgrade of its telephone switch by
October  31, 1999 and  expects to  continue  testing its systems and  developing
contingency   plans  in  the  upcoming   months.   The  Company  has   completed
substantially  all of  its  assessment  of Y2K  risks  relative  to its  outside
vendors.  Planning for contingencies  relating to third party  relationships has
been completed;  however, depending on factors beyond the Company's control that
may  affect  the  Y2K  readiness  of its  vendors,  additional  planning  may be
necessary.

Costs
- -----
The costs of addressing the Y2K issue are not expected to be material to the
operation of the Company. The costs of software and hardware inventories are
currently being absorbed in the normal course of business. The Company
anticipates incurring less than $2,000 for mailing and reviewing Y2K status
reports for external vendors. The costs anticipated by the Company to replace or
upgrade software or hardware are not being accelerated due to Y2K compliance.
These costs totaled approximately $26,000 at June 30, 1999.

Risks
- -----
At this stage of its assessment, the Company does not anticipate that Y2K issues
will  materially   impact  any  of  its  operations,   including   research  and
development,  manufacturing,  supply and distribution and financial control. All
internal  systems are  expected  to be  operational  at the Century  Date Change
(CDC).  However,  due to the large number of the  Company's  vendors  (including
utility companies and governmental bodies) and their reliance, in turn, on other
vendors (including hospitals and distributors),  it is impossible for the impact
of the CDC to be fully  known.  The Company is unable to  determine at this time
whether it will be materially  impacted by unknown  factors beyond the Company's
control affecting third parties or their vendors including royalties the Company
receives  from Fujisawa  Healthcare,  Inc. The Company's Y2K plan is expected to
significantly reduce the Company's level of uncertainty about Y2K issues and, in

                                       11
<PAGE>


particular,  about Y2K  compliance  and readiness of its material  vendors.  The
Company  believes  that,  with  the  completion  of the plan as  scheduled,  the
possibility of significant interruptions of normal operations should be reduced.

Contingency Plans
- -----------------
Contingency  plans have been put in place  relative  to the  Company's  material
vendors,  banking operations and governmental  bodies. Such plans may be updated
based on  information  received  from  vendors  on their  Y2K  readiness.  Other
contingency  plans  may be  developed  on a  vendor-by-vendor  basis  if  deemed
necessary  following  the Company's  further  assessment of (1) Y2K readiness of
other  vendors and (2) the risk of business  interruption  to the  Company.  The
Company's  contingency  planning  takes into account the fact that the Company's
agreements  obligate Fujisawa to maintain six months of finished product and six
months of work-in-process inventories of Adenocard and Adenoscan based on orders
received.  In addition,  in the event  Fujisawa  cannot  fulfill orders for such
drugs on a timely basis consistent with U.S. industry practice for any period in
excess of 30  calendar  days,  Fujisawa is  obligated  to pay  royalties  to the
Company during such "outage" periods based on the average daily net sales of the
drug during the prior twelve  months,  except if such outage  results from force
majeure events.

Disclaimer
- ----------
The discussion of the Company's efforts and management's  expectations  relating
to the Year  2000 are  forward-looking  statements.  The  Company's  ability  to
achieve Y2K  compliance,  to verify external  vendors' Y2K  compliance,  and the
costs  associated  with those  activities are subject to change as the Company's
Y2K plan is  implemented.  Completion  of the plan is dependent on the Company's
ability to discover and correct the potential Y2K sensitive problems which could
have a serious  impact on  operations  and the ability of third party vendors to
bring their systems into Y2K compliance.


CAUTIONARY STATEMENT
- --------------------

The Company operates in a highly competitive  environment that involves a number
of  risks,  some of which  are  beyond  the  Company's  control.  The  following
statement highlights some of these risks.

Statements  contained  in  Management's  Discussion  and  Analysis of  Financial
Conditions and Results of Operations  which are not historical  facts are or may
constitute  forward looking  statements under the safe harbor  provisions of the
Private Securities  Litigation Reform Act of 1995. Although the Company believes
the  expectations  reflected in such  forward  looking  statements  are based on
reasonable  assumptions,  it can give no assurance that its expectations will be
attained.  Forward looking statements involve known and unknown risks that could
cause the Company's actual results to differ  materially from expected  results.
Factors that could cause actual results to differ  materially from the Company's
expectations  include,  among  others,  the  high  cost and  uncertainty  of the
research,   clinical   trials  and  other   development   activities   involving
pharmaceutical products; the Company's ability to fund its activities internally
or through  additional  financing,  if necessary;  the  unpredictability  of the
duration  and  results  of  regulatory  review  of  New  Drug  Applications  and
Investigational New Drug Applications;  the possible impairment of, or inability

                                       12
<PAGE>

to obtain,  intellectual  property  rights and the cost of obtaining such rights
from third parties;  intense competition;  the uncertainty of obtaining, and the
Company's  dependence  on, third parties to  manufacture  and sell its products;
results of pending or future  litigation  and other risk factors  detailed  from
time to time in the Company's  Securities and Exchange Commission  filings.  The
Company does not undertake any  obligation to release  publicly any revisions to
these  statements  to reflect  later events or  circumstances  or to reflect the
occurrence of unanticipated events.


                           PART II: OTHER INFORMATION

Item 1.  Legal Proceedings

Incorporated  herein by reference is the  contingency  described in the Notes to
the Financial Statements set forth in Item 1 of Part I of this Report, set forth
on pages 7 and 8 hereof.

Item 4.  Submission of Matters to a Vote of Security Holders

a)       May 26, 1999 Annual Meeting

b)       Directors Elected -        William M. Bartlett
                                    Roger D. Blevins, Pharm.D.
                                    Jay N. Cohn, M.D.
                                    Mark B. Hirsch
                                    Eugene L. Step
                                    Richard C. Williams

c)       Proposals voted upon:

(i)      Election of Directors:

                  William M. Bartlett
                  For:                               9,590,370
                  Abstain:                              20,883


                  Roger D. Blevins, Pharm.D.
                  For:                               9,590,370
                  Abstain:                              20,883

                  Jay N. Cohn, M.D.
                  For:                               9,590,370
                  Abstain:                              20,883

                                       13
<PAGE>


                  Mark B. Hirsch
                  For:                               9,590,370
                  Abstain:                              20,883

                  Eugene L. Step
                  For:                               9,590,370
                  Abstain:                              20,883

                  Richard C. Williams
                  For:                               9,590,370
                  Abstain:                              20,883

         (ii)     Ratification of PriceWaterhouseCoopers LLP as independent
                  accountants:

                  For:                               9,584,603
                  Against:                               7,452
                  Abstain:                              19,198


Item 6.  Exhibits and Reports on Form 8-K

                  a.       Exhibits:
                           None.

                  b.       Reports on Form 8-K:
                           None.


                                       14
<PAGE>



                                   SIGNATURES


Pursuant to requirements of the Securities  Exchange Act of 1934, the Registrant
has duly  caused  this  report  to be signed  on its  behalf by the  undersigned
thereunto duly authorized.



                                    MEDCO RESEARCH, INC.




Date: August 13, 1999               By:     /s/ Glenn C. Andrews
- ---------------------                       --------------------
                                    Glenn C. Andrews
                                    Executive Vice President
                                    Finance and Administration
                                    Chief Financial Officer and Treasurer




Date: August 13, 1999               By:     /s/ Adam C. Derbyshire
- ---------------------                       ----------------------
                                    Adam C. Derbyshire
                                    Corporate Controller and Secretary


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