SCIOS INC
DEFA14A, 2000-01-20
PHARMACEUTICAL PREPARATIONS
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SCHEDULE 14A INFORMATION

                Proxy Statement Pursuant to Section 14(a) of the
                Securities Exchange Act of 1934 (Amendment No. )

Filed by the Registrant /x/
Filed by a party other than the Registrant / /

Check the appropriate box:
/ / Preliminary Proxy Statement
/ /  Confidential,  for  Use  of the  Commission  Only  (as  permitted  by  Rule
     14a-6(e)(2))
/ / Definitive Proxy Statement
/ / Definitive  Additional Materials
/x/ Soliciting Material Pursuant to Section 240.14a-11(c) or Section
     240.14a-12

                                   Scios Inc.
- --------------------------------------------------------------------------------
                (Name of Registrant as Specified In Its Charter)

- --------------------------------------------------------------------------------
(Name of Person(s) Filing Proxy Statement, if other than the Registrant)

Payment of Filing Fee (Check the appropriate  box):
/x/ No fee required
/ / Fee computed on table below per Exchange  Act Rules  14a-6(i)(1)
     and 0-11

(1) Title of each class of securities to which transaction applies:

- ------------------------------------------------------------------------

(2) Aggregate number of securities to which transaction applies:

- ------------------------------------------------------------------------

(3) Per unit price or other underlying value of transaction computed pursuant to
Exchange  Act Rule  0-11  (set  forth the  amount  on which  the  filing  fee is
calculated and state how it was determined):

- ------------------------------------------------------------------------

(4) Proposed maximum aggregate value of transaction:

- ------------------------------------------------------------------------

(5) Total fee paid:

- ------------------------------------------------------------------------

/ / Fee paid previously with preliminary materials.

/ / Check box if any part of the fee is offset as provided by Exchange Act Rule
     0-11(a)(2) and identify the filing for which the offsetting fee was paid
     previously. Identify the previous filing by registration statement number,
     or the Form or Schedule and the date of its filing.

     (1) Amount Previously Paid:

     ------------------------------------------------------------------------

     (2) Form, Schedule or Registration Statement No.:

     ------------------------------------------------------------------------

     (3) Filing Party:

     -----------------------------------------------------------------------

     (4) Date Filed:

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<PAGE>

              [FORM OF LETTER TO BE SENT TO CERTAIN STOCKHOLDERS]

                               [SCIOS LETTERHEAD]


___________________, 2000

Dear [PERSONALIZE]:


     I appreciated the  opportunity to talk with you about current  developments
at Scios Inc.  Enclosed are a number of press  releases  recently  issued by the
Company that you may find of interest.

     If you have further  questions,  please do not hesitate to call me directly
at 408/(direct  number).  You may also wish to view the Scios investor relations
page on our Website.  Just click on the "Investor  Relations" icon at the bottom
of our home page at www.sciosinc.com. For information about our Year 2000 Annual
Meeting, please access www.sciosinc.com/election.

     We will  continue to keep you  informed  about future  developments  at the
Company. Thank you for your continuing interest in Scios Inc.

Sincerely,


[NAME]
[TITLE]




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