SCIOS INC
DEFA14A, 2000-01-20
PHARMACEUTICAL PREPARATIONS
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SCHEDULE 14A INFORMATION

                Proxy Statement Pursuant to Section 14(a) of the
                Securities Exchange Act of 1934 (Amendment No. )

Filed by the Registrant /x/
Filed by a party other than the Registrant / /

Check the appropriate box:
/ / Preliminary Proxy Statement
/ /  Confidential,  for  Use  of the  Commission  Only  (as  permitted  by  Rule
     14a-6(e)(2))
/ / Definitive Proxy Statement
/ / Definitive  Additional Materials
/x/ Soliciting Material Pursuant to Section 240.14a-11(c) or Section
     240.14a-12

                                   Scios Inc.
- --------------------------------------------------------------------------------
                (Name of Registrant as Specified In Its Charter)

- --------------------------------------------------------------------------------
(Name of Person(s) Filing Proxy Statement, if other than the Registrant)

Payment of Filing Fee (Check the appropriate  box):
/x/ No fee required
/ / Fee computed on table below per Exchange  Act Rules  14a-6(i)(1)
     and 0-11

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(2) Aggregate number of securities to which transaction applies:

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(3) Per unit price or other underlying value of transaction computed pursuant to
Exchange  Act Rule  0-11  (set  forth the  amount  on which  the  filing  fee is
calculated and state how it was determined):

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/ / Fee paid previously with preliminary materials.

/ / Check box if any part of the fee is offset as provided by Exchange Act Rule
     0-11(a)(2) and identify the filing for which the offsetting fee was paid
     previously. Identify the previous filing by registration statement number,
     or the Form or Schedule and the date of its filing.

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     (4) Date Filed:

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<PAGE>
                                  [SCIOS LOGO]
                             820 West Maude Avenue
                              Sunnnyvale, CA 94086
                                www.sciosinc.com

CONTACT:
- --------
Wendy Carhart
Scios Inc.
408/616-8325
or
Stanley J. Kay
MacKenzie Partners, Inc.
212/929-5940

FOR IMMEDIATE RELEASE:
- ----------------------

                 SCIOS BOARD MAILS LETTER AND PROXY STATEMENT TO
                STOCKHOLDERS FOR FEBRUARY 28, 2000 ANNUAL MEETING
     -- Board also responds to latest communication from Randal J. Kirk --

SUNNYVALE,  CALIFORNIA  -- January 20, 2000 -- The Board of  Directors  of Scios
Inc.  (NASDAQ:  SCIO)  today  mailed a letter  to  stockholders  with its  Proxy
Statement indicating its view of the proxy contest launched by Mr. Kirk to seize
control  of the Board and urging  stockholders  to return the GOLD proxy card to
vote for the Board's slate of directors. The Board renewed its commitment to the
Natrecor(R)  Phase III VMAC  clinical  trial,  the  development  of a p38 kinase
inhibitor for the treatment of arthritis,  and the  preservation  of cash assets
for these projects.

Donald B. Rice,  Chairman of the Board,  and Richard B.  Brewer,  President  and
Chief  Executive  Officer of Scios,  stated that "The  individuals  on the Scios
slate  stand  head  and  shoulders   above  the  nominees  put  forward  by  Mr.
Kirk...Moreover,  taken as a whole, Kirk's slate has not revealed any meaningful
experience  in  leading  a  company  such  as  Scios  that is  dedicated  to the
discovery, development and commercialization of new biopharmaceutical products."
The letter also points out that, based on the biographies provided in Kirk's own
proxy statement:

     o    Only one of Kirk's  nominees  has  served as a senior  executive  of a
          publicly traded company.

     o    Only one of Kirk's  nominees has ever served on the board of directors
          of a public company.

     o    Only one of Kirk's  nominees - Kirk  himself - owns a single  share of
          Scios stock.

                                   -- more --

<PAGE>

                                                                January 20, 2000
                                                                          Page 2

The letter also outlines the impressive  qualifications of Scios' seven nominees
for  reelection  in 2000.  These  individuals  have  served as  chairmen,  chief
executive officers,  chief operating officers and other senior positions at some
of  America's  largest  and most  prominent  companies,  academic  and  research
institutions and government agencies.  These seven candidates also bring to your
Board broad  experience,  currently  serving as  directors  of 19 other U.S. and
European publicly-traded corporations.

Separately,  the Company  announced that the Board has  preliminarily  discussed
Randal Kirk's open letter dated January 18, 2000.  The Board noted that over the
past two years it has carefully  considered,  with management,  all of the ideas
now also put forth in Mr.  Kirk's  letter.  Some of these ideas have been either
implemented or included in the company's business plan, while others were deemed
not in the long-term interest of Scios.  Nevertheless,  in order to give Kirk an
opportunity  to elaborate on his ideas,  Scios  Directors  will meet with him as
soon as a meeting can be arranged.

A copy of the letter mailed to stockholders is attached.

Scios Inc.
- ----------

Scios is a biopharmaceutical company engaged in the discovery,  development, and
commercialization of novel human therapeutics.  Scios has commercial or research
and   development   relationships   with   Chiron   Corporation,    The   DuPont
Pharmaceuticals   Company,   Eli  Lilly  and   Company,   GenVec   Inc.,   Kaken
Pharmaceutical  Co., Ltd., and Novo Nordisk A/S of Denmark.  Scios'  Psychiatric
Sales and Marketing Division  successfully  markets seven psychiatric  products,
including  co-promotion  arrangements  on Janssen  Pharmaceutica's  Risperdal(R)
(risperidone)  and SmithKline  Beecham's  Paxil(R)  (paroxetine  hydrochloride).
Additional  information  on  Scios  is  available  at its web  site  located  at
www.sciosinc.com  and in the Company's  various  filings with the Securities and
- ----------------
Exchange Commission.  For information about the Year 2000 Annual Meeting,  visit
www.sciosinc.com/election.
- -------------------------

                                   -- end --
<PAGE>

[SCIOS LOGO]

Scios Inc.
820 West Maude Avenue
Sunnyvale, CA 94086
408 481 9177 Tel
408 481 9188 Fax

January 20, 2000

DEAR STOCKHOLDER:

     You are  cordially  invited  to  attend  Scios  Inc.'s  Annual  Meeting  of
Stockholders on February 28 at 9:00 a.m. at the Company's  office located at 749
North Mary Avenue, Sunnyvale,  California 94086. Enclosed is our proxy statement
which we encourage you to read.

     As we approach the annual  meeting,  Scios is in a very critical  period in
its history.  Our ability to achieve our new business  plan is highly  dependent
upon  the  continued  commitment  of  our   employee/management   team  and  the
preservation  of  cash  assets  for  top  priority  projects,  such  as the  new
Natrecor(R)  VMAC Phase III  clinical  trial and our  program to develop our p38
arthritis drug.

     In our view, the proxy fight launched by Randal J. Kirk to seize control of
your Board is  designed  to gain  access to the  company's  scientific  and cash
assets.

     We believe that Kirk's efforts are  threatening  Scios' ability to complete
its important clinical and discovery  research projects.  It is very unfortunate
that in order to  protect  the  interests  of all  stockholders  against  Kirk's
actions,  we are being forced to spend corporate assets and energy that would be
better devoted to implementing the company's new business plan.

     We very much regret that this proxy contest will inconvenience you with its
numerous mailings and generate negative publicity  regarding Scios. We know that
the  nonapproval  of  Natrecor(R)  was  a  major   disappointment  for  everyone
interested in Scios--our employees,  management and Board of Directors, but most
especially for you, our stockholders.

     None of us needs Kirk to tell us that.  Unfortunately,  Kirk's actions come
just as we  believe  we are well  under  way in  recovering  from  the  Natrecor
setback.

     Following  the FDA's  decision,  Scios has  designed  and  started  the new
Natrecor  trial very quickly and patient  enrollment  is on track.  We expect to
complete  this  trial and file an  amended  NDA for  Natrecor  in 2000 that will
support FDA approval in 2001.

     The management team and Board of Scios ask for your  continuing  support so
that we can  complete  the  Natrecor  program for you and the many  patients who
await  this  important  new  therapy.  Enclosed  with this  letter and the proxy
statement is a GOLD proxy card which you can use to vote FOR your Board's  slate
of seven director-nominees.

<PAGE>

     We believe the seven  Directors of Scios  nominated for your reelection are
exception-ally  well-qualified  individuals to lead Scios in 2000. We ask you to
review their credentials at the end of this letter.

     They have served as chairmen,  chief  executive  officers,  chief operating
officers  and other  senior  positions  at some of  America's  largest  and most
prominent companies, academic and research institutions and government agencies.
These  seven  candidates  also bring to your Board broad  experience,  currently
serving as directors of 19 other U.S. and European publicly-traded corporations.

     We think you will agree that the  individuals on the Scios slate stand head
and shoulders  above the nominees put forward by Mr. Kirk. In particular,  based
on the biographies  provided in Kirk's own proxy  statement  asking you to elect
his slate, it is clear that Kirk's slate lacks the  qualifications to become the
board of Scios because:

     o    Only one of Kirk's nominees has ever served as a senior executive of a
          publicly traded company.

     o    Only one of Kirk's  nominees has ever served on the board of directors
          of a public company.

     o    Only one of  Kirk's  nominees--Kirk  himself--owns  a single  share of
          Scios stock.

     Moreover,  taken as a whole,  Kirk's slate has not revealed any  meaningful
experience  in  leading  a  company  such  as  Scios  that is  dedicated  to the
discovery, development and commercialization of new biopharmaceutical products.

     One of the  country's  most  respected  institutional  investors and Scios'
largest  institutional  owner,  the State of  Wisconsin  Investment  Board,  has
considered Mr. Kirk's slate and decided to reject it.  Instead,  SWIB has stated
that it will  vote  the  GOLD  proxy  card to  support  the  current  Board  and
management as the "right team" to realize the potential of Scios' strong product
pipeline and build long-term stockholder value.

     Your vote is also  important to us. Please take a moment to sign and return
the  enclosed  GOLD proxy card voting FOR your  Board's  nominees.  Please do so
today.  If you have  previously  signed Kirk's WHITE proxy card,  you can change
your vote to support  your current  Board simply by signing,  dating and mailing
the enclosed GOLD proxy card.

     We will continue to keep you informed about further developments  regarding
our business plan and the progress of our clinical trials. We also encourage you
to visit the Company's  website at  www.sciosinc.com.  For information about the
Year 2000 annual meeting, please access the page www.sciosinc.com/election.

     We  appreciate  your  support  of Scios and  encourage  your  questions  or
comments.  Please call our investor  relations  department at (408)  616-8325 or
MacKenzie Partners, Inc., toll-free at (800) 322-2885.

<PAGE>

     Scios' primary focus is building long-term value for all stockholders.  You
can best support this effort by signing and  returning  the enclosed  GOLD proxy
card.

                       On Behalf of the Board of Directors

                                   Sincerely,

         /s/                             /s/
         DONALD B. RICE                  RICHARD B. BREWER
         Chairman of the Board           President and Chief Executive Officer

                               IMPORTANT BULLETIN

     We have just received as we are going to press on this letter,  a letter to
Scios'  Chairman from Randal Kirk,  issued by press release,  outlining his plan
for Scios and holding out the possibility that he might withdraw his proposal if
he obtains  minority board  representation  and a mutually  agreeable  plan. The
Scios  Board  has  not  had  the   opportunity  to  give  Kirk's  plan  detailed
consideration  given the timing of this mailing.  However,  the Scios Board also
noted  that,  working  with  management,   it  has  over  the  last  two  years,
particularly  in the planning of the 1999  restructuring,  considered all of the
ideas put forward by Mr.  Kirk.  Some have been  implemented  or included in our
business  plan,  while others were deemed at the time not to be in the long-term
interests  of  Scios.  Nevertheless,  in order to give  Kirk an  opportunity  to
elaborate on his ideas,  Scios Directors will meet with him as soon as a meeting
can be arranged.

     The Board  sincerely  hopes  that Mr.  Kirk's  effort  today is more than a
tactic in this proxy contest. For you, the Scios stockholders, the central issue
remains which slate is best qualified to guide Scios.  We are confident that you
will agree with us that the current  Scios Board of  Directors is the best slate
for all  stockholders  and ask that you sign the GOLD  proxy  card and return it
today.

If you have any questions or need  assistance  completing your proxy card please
call:
MacKenzie Partners, Inc.
156 Fifth Avenue
New York, New York 10010
(212)929-5500 (call collect)
or
call toll-free (800)322-2855

<PAGE>

           Backgrounds and Credentials of the Scios Director-Nominees

Donald B. Rice, Ph.D. was elected Chairman of the Board in November 1998 and has
served as a Director  of Scios since  August  1997.  Dr. Rice is the  President,
Chief Executive Officer and Director of UroGenesys,  Inc. Previously,  he served
Teledyne,  Inc. as President,  Chief Operating Officer and Director from 1993 to
1996, the U.S.  Department of Defense as Secretary of the Air Force from 1989 to
1993,  and The RAND  Corporation as President and Chief  Executive  Officer from
1972 to 1989. He was also  Assistant  Director of the Office of  Management  and
Budget, The White House. Dr. Rice is a member of the Board of Directors of Wells
Fargo & Company, Vulcan Materials Company and Unocal Corporation.

Richard B.  Brewer is  President  and Chief  Executive  Officer of Scios Inc. He
joined  Scios in  September  1998 and has served as a Director  since that time.
From early 1996 to 1998, he was with  Heartport  Inc.,  first as Executive  Vice
President of Operations and then,  Chief Operating  Officer.  Prior to that, Mr.
Brewer served in various capacities with Genentech, Inc. from 1984 to 1995, most
recently as Senior Vice President,  U.S. Sales and Marketing,  Genentech  Europe
Ltd.,  and  Genentech  Canada,  Inc.  Mr.  Brewer  earned a B.S.  from  Virginia
Polytechnic Institute and a M.B.A. from Northwestern University.

Samuel  Armacost was elected to the Company's Board of Directors in August 1995.
In July 1998,  Mr.  Armacost  became  Chairman of the Board of  Directors of SRI
International.  From 1990 to 1998, he was a Managing  Director of Weiss,  Peck &
Greer,  LLC, an  investment  firm.  He was a Managing  Director of Merrill Lynch
Capital Markets from 1987 to August 1990, and was President,  Director and Chief
Executive Officer of BankAmerica  Corporation from 1981 to 1986. Mr. Armacost is
a member of the Board of Directors of Chevron Corporation and Exponent,  Inc. In
addition,  Mr.  Armacost  is on the  Board  of  Directors  of the  James  Irvine
Foundation and the Advisory Board of the California Academy of Sciences,  and he
is a member of the International  Advisory Group for Toshiba Corporation and The
Business Council.

Charles A. Sanders,  M.D. was elected a Director of Scios in September  1997. He
served as Chief  Executive  Officer  of Glaxo  Inc.  from 1989 to 1994,  and was
Chairman  of the  Board  from  1992 to  1995.  He also  served  on the  Board of
Directors  of Glaxo plc.  Previously,  he held a number of  positions  at Squibb
Corporation,  a  multinational   pharmaceutical   corporation,   including  Vice
Chairman,  Chief  Executive  Officer of the  Science  and  Technology  Group and
Chairman of the Science and Technology  Committee of the Board. Dr. Sanders is a
member  of  the  Board  of   Directors  of  Magainin   Pharmaceuticals,   Vertex
Pharmaceuticals, Staff Mark, Inc., Kendle International, Trimeris, Pharmacopeia,
Genentech, Inc. and Biopure.

Solomon H. Snyder,  M.D. was elected a Director in September 1992. Dr. Snyder is
Director of the Department of Neuroscience and  Distinguished  Service Professor
of Neuroscience, Pharmacology and Molecular Sciences and Psychiatry at The Johns
Hopkins  University,  and has been a member of the faculty there since 1966. Dr.
Snyder  received  the Albert  Lasker  Award for Basic  Biomedical  Research  and
Honorary  Doctor of Science  degrees from  Northwestern  University,  Georgetown
University  and Ben Gurion  University.  Dr. Snyder  received the Wolfe Award in
Medicine from the government of Israel for research  relating to receptors.  Dr.
Snyder is a member  of the  National  Academy  of  Sciences  and a Fellow of the
American Academy of Arts and Sciences. Dr. Snyder is also the author of numerous
articles and several  books.  Dr. Snyder is a founder and a director of Guilford
Pharmaceuticals Inc.

Burton E. Sobel,  M.D.  was elected a Director in February  1996.  Dr.  Sobel is
Physician-in-Chief,  E.L.  Amidon  Professor  and  Chair  of the  Department  of
Medicine at The University of Vermont College of Medicine. Previously, Dr. Sobel
was Professor of Medicine at Barnes Hospital, Washington University and Director
of its Cardiovascular Division. Dr. Sobel has been a consultant to and served on
scientific   advisory  boards  of  several   pharmaceutical   and  biotechnology
companies,  served as a director of Squibb  Corporation from 1986 to 1989 and is
also a member of the Board of Directors of Fletcher Allen Health Care. Dr. Sobel
has  been the  recipient  of  numerous  awards,  including  the  American  Heart
Association's James B. Herrick Award and its Scientific Council's  Distinguished
Achievement Award, as well as the American College of Cardiology's Distinguished
Scientist  Award.  Dr. Sobel has been the editor of Circulation and, since 1989,
has served as editor of Coronary Artery Disease. His memberships and fellowships
include the American College of Physicians,  Royal Society of Medicine, American
Heart  Association,  American  College of Cardiology  and Fellowship and Council
member-ship in the American Association for the Advancement of Science.

Eugene L. Step was elected a Director in February  1993.  From May 1956 until he
retired in December 1992,  Mr. Step was employed by Eli Lilly and Company,  most
recently as Executive Vice President,  President of the Pharmaceutical Division,
where  he was  responsible  for  U.S.  pharmaceutical  operations  and  for  the
operations  of Eli Lilly  International.  In  addition,  Mr.  Step served on Eli
Lilly's Board of Directors and executive committee. Mr. Step was Chairman of the
Board of Directors of the Pharmaceutical Manufacturers Association and President
of the International Federation of Pharmaceutical Manufacturers Associations. He
is a member of the Board of Directors of Cell Genesys Inc., Guidant Corporation,
Medco Research Inc., Pathogenesis Corporation and DBT Online Inc.



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