SCIOS INC
8-K, 2000-02-01
PHARMACEUTICAL PREPARATIONS
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                                 UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                    FORM 8-K

                                 CURRENT REPORT

                     Pursuant to Section 13 or 15(d) of the
                         Securities Exchange Act of 1934

                                January 31, 2000
                        (Date of earliest event reported)

                                   SCIOS INC.
             (Exact name of registrant as specified in its charter)

   Delaware                      0-11749                    95-3701481
(State of other         (Commission file number)        (I.R.S. Employer
 jurisdiction of                                         Identification No.)
 incorporation)

                              820 West Maude Avenue
                           Sunnyvale, California 94086
              (Address of principal executive offices and zip code)

                                 (408) 616-8200
                         (Registrant's telephone number)

<PAGE>

ITEM 5.  OTHER EVENTS

         On  January  31,  2000,  Scios  Inc.  (the  "Company")  entered  into a
Settlement  Agreement  (the  "Settlement  Agreement")  with  Randal  J. Kirk and
certain entities controlled by him (the  "Stockholders") that had nominated (the
"Nomination")  an  alternate  slate of Mr.  Kirk  and six  other  nominees  (the
"Stockholder  Nominees")  for election to the Company's  Board of Directors (the
"Company  Board") at the 2000 annual meeting of stockholders of the Company (the
"2000 Annual Meeting").

         The  Settlement  Agreement  terminates  the proxy  contest  between the
parties. Under the Settlement Agreement,  Mr. Kirk has been added to the Company
Board's  slate of nominees  for  election to a one-year  term at the 2000 Annual
Meeting,  increasing  the  total  number  of  Company  Board  nominees  to eight
(including the seven existing nominees of the Company Board, who are all current
members of the Company  Board).  The Company  Board has agreed to recommend  the
election of all eight nominees.  The Stockholders  have withdrawn the Nomination
and have agreed to  discontinue  all efforts  (direct and  indirect)  to solicit
votes for the Stockholder Nominees or otherwise to pursue the Nomination.

         The Settlement Agreement provides that the Stockholders will vote their
Company shares in favor of the Company Board's  nominees and against the removal
of any director,  and not pursue any unsolicited  acquisition attempts or engage
in any proxy  contest,  for a specified  period (the "Term").  The length of the
Term will depend on whether Mr. Kirk is elected at the 2000 Annual  Meeting and,
if he is, on whether the Company Board chooses to  re-nominate  Mr. Kirk for the
2001 annual meeting of stockholders of the Company (the "2001 Annual  Meeting").
If Mr. Kirk is not elected at the 2000 Annual  Meeting,  the Term will expire at
the conclusion of that meeting. If he is elected at that meeting,  the Term will
expire at the earliest to occur of:

          o    Mr. Kirk's  resignation  from the Company Board within 15 days of
               the Company Board deciding,  at a meeting  required to be held no
               later than 90 days before the 2001 Annual  Meeting,  that he will
               not  be  re-nominated  at  that  meeting,   in  which  event  the
               provisions of the Company's Bylaws requiring advance notice to be
               given,  by a specified  date, of  a  stockholder's  intention  to
               nominate  directors,  or  propose  other  business,  at an annual
               meeting of  stockholders  (the "Advance  Notice  Bylaws") will be
               waived  to  the  extent  necessary  to  permit  any or all of the
               Stockholders  (but no other  person) to  nominate  one or more of
               their own  candidates  for  election to the Company  Board at the
               2001 Annual Meeting;

          o    the  conclusion  of  the  2001  Annual  Meeting  if Mr.  Kirk  is
               re-nominated for election at that meeting but is not elected; or

                                       1

<PAGE>

          o    the later of (i) the 30th day prior to the  deadline  established
               by the Advance  Notice Bylaws for  nominations  of candidates for
               election  to the  Company  Board at the 2002  annual  meeting  of
               stockholders  of the Company (the "2002 Annual  Meeting") or (ii)
               the date of Mr. Kirk's resignation from the Company Board, but in
               no event beyond the conclusion of the 2002 Annual Meeting.

         In  addition,  during  the Term (or until  Mr.  Kirk  resigns  from the
Company Board before the end of the Term, if he is elected), the Stockholders:

          o    must vote all of their  Company  shares on all matters other than
               the  election or removal of  directors  either (as they choose in
               their sole discretion) in accordance with the recommendation of a
               majority of the Company Board or in the same proportion as shares
               held by the other Company stockholders are voted;

          o    may not increase  their  aggregate  ownership  of Company  shares
               above 7.2% and must effect all purchases in  compliance  with all
               then-applicable  Company policies  regarding  compliance with the
               federal  securities  laws  and  transactions  in  Company  voting
               securities by members of the Company  Board and their  affiliates
               (the "Company Policies"); and

          o    must give the Company  prior  notice if they intend to dispose of
               any of their Company  shares  (except that  open-market  sales of
               less than 1%, in the  aggregate,  in any  90-day  period  are not
               subject to this notice  requirement) and must effect all sales in
               compliance with the Company Policies.

         The Settlement  Agreement contains certain other provisions,  including
restrictions  on public  announcements,  mutual releases of claims in connection
with the proxy contest and related covenants not to sue, certain representations
and warranties,  and the Company's  agreement to reimburse 50% of certain of the
Stockholders' actual documented out-of-pocket costs in connection with the proxy
contest.  In  addition,  the Company has agreed that,  without Mr.  Kirk's prior
consent (not to be  unreasonably  withheld),  it will not change the date of the
2000 Annual  Meeting,  hold the 2001 Annual  Meeting later than June 1, 2001, or
amend the Advance Notice Bylaws during the Term.

         The Settlement  Agreement permits Mr. Kirk to exercise his rights,  and
fulfill his obligations, as a member of the Company Board while he is serving on
it, and to make confidential  proposals to the Company Board,  without violating
any of the provisions summarized above.

         THE FOREGOING SUMMARY OF CERTAIN PROVISIONS OF THE SETTLEMENT AGREEMENT
IS QUALIFIED BY THE FULL TEXT THEREOF,  WHICH IS FILED  HEREWITH AS EXHIBIT 99.1
(SEE ITEM 7(C)).

                                       2

<PAGE>

         ITEM 7(C)  EXHIBITS

         Exhibit 99.1           The Settlement Agreement (excluding Exhibit 4.1
                                thereto, which is the form of joint press
                                release; see Exhibit 99.2)

         Exhibit 99.2           Joint press release issued on January 31, 2000



                                   SIGNATURES

Pursuant  to the  requirements  of the  Securities  Exchange  Act of  1934,  the
registrant  has duly  caused  this  report  to be  signed  on its  behalf by the
undersigned hereunto duly authorized.

                                                SCIOS INC.
                                                (Registrant)

                                                /s/ John H. Newman
Date:  February 1, 2000                         _____________________________
                                                John H. Newman
                                                Senior Vice President,
                                                General Counsel and Secretary

                                       3



                              SETTLEMENT AGREEMENT

         This Settlement  Agreement (this "Agreement") is made as of January 31,
2000 by and among Scios Inc., a Delaware corporation (the "Company"),  Randal J.
Kirk, a citizen of the United  States ("Mr.  Kirk"),  and each of the  following
entities  that Mr. Kirk  directly  controls:  RJK,  L.L.C.,  a Virginia  limited
liability  company ("RJK");  Kirkfield,  L.L.C.,  a Virginia  limited  liability
company ("Kirkfield"), and The Kirk Family Investment Plan, a joint account (the
"Plan" and, together with Mr. Kirk, RJK and Kirkfield, the "Stockholders").

                                    RECITALS:

         A. The  Stockholders  have  reported  on a Schedule  13D dated July 29,
1999, as amended (the "Schedule 13D"), that they are the beneficial owners of an
aggregate of 2,000,000  outstanding  shares of the Company's  common stock,  par
value $.001 per share (the "Company Common Stock"),  representing  approximately
5.2% of the outstanding Company Common Stock.

        B. By a letter dated December 2, 1999 addressed to the Company, as
modified by a Supplement dated January 19, 2000 to their proxy statement dated
January 11, 2000, the Stockholders have nominated (the  "Nomination") Mr. Kirk
and six other candidates (the  "Stockholder  Nominees") for election to the
Board of  Directors of the Company (the "Company Board"), in place of the
current members of the Company Board, at the 2000 annual meeting of stockholders
of the Company to be held on February 28, 2000 (as the same may be adjourned or
postponed  from time to time,  the "2000 Annual Meeting").  The current members
of the Company  Board, all but one of whom are candidates for re-election at the
2000 Annual Meeting, have opposed the election of the Stockholder Nominees and
the parties to this Agreement (the  "Parties") have commenced a proxy contest
(the "Proxy Contest") regarding the election of their respective nominees to the
Company Board at the 2000 Annual Meeting.

        C. The Parties wish to settle the Proxy Contest, and enter into certain
agreements related thereto, on the terms of this Agreement.

        NOW, THEREFORE, in consideration of the mutual promises of the Parties
contained herein and for other good and valuable consideration, the receipt and
sufficiency of which is hereby acknowledged, the Parties hereby agree as
follows:

1.       DEFINITIONS

         In  addition  to the  other  definitions  contained  elsewhere  in this
Agreement,  the following terms shall have the meanings  specified below for the
purposes hereof:

<PAGE>

        "Advance Notice Bylaws" means Sections 5(b) and 5(c), together,  of the
Company's  Bylaws as in effect on the date hereof or any amended version thereof
or successor thereto in effect at the time of determination under the applicable
provision hereof.

        "Affiliate" has the meaning set forth in the 1934 Act.

        "Associate" has the meaning set forth in the 1934 Act.

        "Beneficially  own"  has  the  meaning  set  forth  in the  regulations
included in Rule 13d-3 of the 1934 Act; provided,  however, that for purposes of
this Agreement,  any option, warrant, right, conversion privilege or arrangement
to purchase,  acquire or vote Company Voting Securities,  regardless of the time
period  during or the time at which it may be exercised  and  regardless  of the
consideration  paid,  shall be  deemed  to give the  holder  thereof  beneficial
ownership  of the Company  Voting  Securities  to which it relates.  Any Company
Voting  Securities  which  are  subject  to  such  options,   warrants,  rights,
conversion  privileges or other  arrangements  shall be deemed to be outstanding
for purposes of computing the percentage of outstanding securities owned by such
Person but shall not be deemed to be  outstanding  for purposes of computing the
percentage of outstanding securities owned by any other Person.

        "Company Voting  Securities"  means all classes of capital stock of the
Company which are then  entitled to vote  generally in the election of directors
and  any  securities  exchanged  for  such  classes  of  capital  stock  and any
securities  convertible  into or exchangeable or exercisable for such classes of
capital  stock.  For  purposes  of  determining  the  amount  or  percentage  of
outstanding  Company Voting Securities  beneficially  owned by a Person, and for
purposes of  calculating  the  aggregate  voting power  relating to such Company
Voting  Securities,  securities  that  are  deemed  to be  outstanding  shall be
included to the extent provided in the definition of "Beneficially own."

        "1933  Act"  means the  Securities  Act of 1933,  as  amended,  and the
regulations promulgated under such statute.

        "1934 Act" means the Securities  Exchange Act of 1934, as amended,  and
the regulations promulgated under such statute.

        "Person"   means  a  natural   person  or  any  legal,   commercial  or
governmental entity, including, but not limited to, a corporation,  partnership,
joint venture,  trust, limited liability company, group acting in concert or any
person acting in a representative capacity.

                                       2

<PAGE>

        "Representatives"  of a  Party  means:  (a)  the  officers,  directors,
partners,  managers or other authorized  representatives  of such Party; (b) the
employees or agents of such Party but only to the extent that they act on behalf
of such Party; and (c) the outside professional  advisors of such Party but only
to the extent  that they act in concert  with such Party and not solely in their
capacities as professional advisors.

        "SEC" means the Securities and Exchange  Commission.

        "Securities Acts" means the 1933 Act and the 1934 Act.

        "Term" means the period  commencing  on the date of this  Agreement and
continuing until the earliest to occur of: (a) the conclusion of the 2000 Annual
Meeting should Mr. Kirk, having been nominated for election to the Company Board
thereat  pursuant to Section  3.1,  not be so elected  thereat;  (b) Mr.  Kirk's
resignation  from the Company Board  pursuant to Section 3.5; (c) the conclusion
of the annual  meeting of  stockholders  of the  Company  for the year 2001 (the
"2001 Annual  Meeting")  should Mr. Kirk,  having been nominated for election to
the Company Board thereat pursuant to Section 3.4, not be so elected thereat; or
(d) the  later of (i) the 30th day  prior  to the  deadline  established  by the
Advance Notice Bylaws for  nominations of candidates for election to the Company
Board at the annual  meeting of  stockholders  of the  Company for the year 2002
(the "2002 Annual Meeting"), or (ii) the date of Mr. Kirk's resignation from the
Company Board, but in no event beyond the conclusion of the 2002 Annual Meeting.

2.      WITHDRAWAL OF THE NOMINATION

        2.1.    The Stockholders hereby irrevocably withdraw the Nomination.

        2.2.    The Stockholders shall forthwith discontinue all efforts (direct
and indirect) to solicit votes for the Stockholder Nominees and shall not engage
in any further solicitation activity (whether by press release, SEC filings,
mailings to the  stockholders of the Company, communications with individual
stockholders of the Company, contacts with the media or otherwise) to solicit
votes for the Stockholder Nominees or otherwise to pursue the Nomination.

3.      ADDITION OF MR. KIRK AS A COMPANY BOARD NOMINEE

        3.1.    The Company Board has taken all action necessary to cause Mr.
Kirk to become a nominee of the Company Board for election to the Company Board
at the 2000 Annual Meeting. If he is elected and chooses to serve, Mr. Kirk will
serve as a member of the Company Board for the same term as all other nominees
elected to the Company Board at the 2000 Annual Meeting, which term shall expire
when his successor is duly elected at the 2001 Annual Meeting and qualified or
upon his death, resignation or

                                       3

<PAGE>

removal, all as provided in Article IV of the Company's Bylaws.  As a result of
the addition of Mr. Kirk as a nominee of the Company Board for election to the
Company Board at the 2000 Annual Meeting, the total number of the Company Board
nominees for  election at the 2000 Annual Meeting shall be eight and the Company
Board shall  recommend to the Company's stockholders the election of all eight
nominees.

        3.2.    If, at any  time, whether before the vote is taken on the
election of directors at the 2000 Annual Meeting or thereafter (assuming Mr.
Kirk is elected thereat), Mr. Kirk  becomes unable or unwilling to serve as a
member of the Company Board, the Company Board shall have no obligation to
nominate, elect or appoint a successor or replacement to Mr. Kirk.

        3.3.    Mr. Kirk hereby confirms to the Company his consent to stand for
election as a nominee of the Company Board at the 2000 Annual Meeting. In
addition to the information that Mr. Kirk has provided to the Company in
connection with the negotiation and execution of this Agreement, Mr. Kirk shall
provide to the Company such additional information as it may from time to time
reasonably request for inclusion in materials to be disseminated in connection
with the 2000 Annual Meeting or otherwise in order for it to comply with its
disclosure requirements under the Securities Acts.

        3.4.    If Mr. Kirk is elected to the Company Board at the 2000 Annual
Meeting and is still a member of the Company Board at the meeting at which the
Company Board votes on its nominees (the "2001 Nominees") for election to the
Company Board at the 2001 Annual Meeting, which  nomination meeting of the
Company Board (the "Nomination  Meeting") the Company covenants to hold no later
than 90 days prior to the date of the 2001 Annual  Meeting, then, at the
Nomination  Meeting,  the Company Board shall have the right (but not the
obligation) to vote to include Mr. Kirk as one of the 2001 Nominees, in which
case, if Mr. Kirk consents to stand for election as a 2001 Nominee: (a) the
Company Board shall recommend to the Company's stockholders his election,
together with the election of all other 2001 Nominees, at the 2001 Annual
Meeting; and (b) the provisions of the second sentence of Section 3.1 and the
entirety of Section 3.2 shall apply as if references therein to the 2000 Annual
Meeting were references to the 2001 Annual Meeting, and the reference in the
second sentence of Section 3.1 to the 2001 Annual Meeting was a reference to the
2002 Annual Meeting.

        3.5.    If, at the Nomination Meeting, the Company Board votes not to
include Mr. Kirk as one of the 2001 Nominees and Mr. Kirk resigns from the
Company Board within 15 days of such vote, the Advance Notice Bylaws shall
automatically be deemed waived to the extent necessary to permit any or all of
the Stockholders (but no other Person) to nominate one or more of their own
candidates for election to the Company Board at the 2001 Annual Meeting.

                                       4
<PAGE>

        3.6.    If, at the Nomination Meeting, the Company Board votes to
include Mr. Kirk as one of the 2001 Nominees but Mr. Kirk does not consent to
stand for election as a 2001 Nominee, the Advance Notice Bylaws shall not be
deemed waived to any extent with respect to any of the Stockholders.

4.      ANNOUNCEMENTS

        4.1.    As soon as practicable following the execution of this
Agreement: (a) the Company and Mr. Kirk shall issue a joint press release in the
form of Exhibit 4.1 hereto (the "Joint  Press  Release"), which the Company (but
not the Stockholders) shall file with the SEC as additional definitive proxy
materials under the 1934 Act; (b) the Company shall file with the SEC, and
disseminate to its  stockholders, a letter to its stockholders and a supplement
to its proxy statement for the 2000 Annual Meeting  disclosing,  in a manner
consistent with the Joint Press Release, the terms of this Agreement and Mr.
Kirk's  nomination pursuant to Section 3.1, together with the information
provided by Mr. Kirk, for inclusion in such supplement, with respect to himself,
the contents of which letter and supplement shall be subject to the approval of
Mr. Kirk (not to be unreasonably withheld); (c) the Company shall file with the
SEC a Current Report on Form 8-K to disclose this Agreement in a manner
consistent with the Joint Press Release, the contents of which Current Report
shall be subject to the approval of Mr. Kirk (not to be unreasonably withheld);
and (d) the Stockholders shall file with the SEC a Schedule 13D amendment to
disclose this Agreement in a manner consistent with the Joint Press Release, the
contents of which amendment shall be subject to the approval of the Company (not
to be unreasonably withheld)

        4.2.    From the date of this Agreement until the earlier to occur of
(a) the expiration of the Term or (b) the  resignation of Mr. Kirk from the
Company Board (if he is  elected  thereto), none of the Parties shall make any
public statement (including any statement in any filing with the SEC or any
other governmental agency) regarding this Agreement or any event occurring prior
to the date hereof that is inconsistent with, or otherwise  contrary to, the
Joint Press Release or that is critical of any other Party or its prior actions.

        4.3.    Any public statement (including any statement in any filing with
the SEC or any other governmental agency) by any Party regarding this Agreement
or any event occurring prior to the date hereof that is not prohibited by
Section 4.2 shall be made in compliance with applicable securities laws and
consistent with such Party's fiduciary duties to the Company.

                                       5

<PAGE>

5.      STANDSTILL PROVISIONS

        5.1.    Provided that the Company is not in material default under this
Agreement, the Stockholders agree, jointly and severally, that prior to the
expiration of the Term, unless such shall have been specifically invited in
writing by the Company, none of the Stockholders nor any of their Affiliates,
Associates or Representatives shall in any manner, directly or indirectly:

               (a)  effect  or  seek,  offer or  propose  (whether  publicly  or
          otherwise) to effect,  or cause or participate in or in any way assist
          any other person to effect or seek, offer or propose (whether publicly
          or  otherwise)  to  effect  or  participate  in (i)  any  acquisition,
          issuance or disposition  of any  securities  (or beneficial  ownership
          thereof) or assets of the Company or any of its  subsidiaries  (except
          as otherwise  expressly  provided by Section 6.4),  (ii) any tender or
          exchange  offer,  merger or other business  combination  involving the
          Company  or any  of  its  subsidiaries,  (iii)  any  recapitalization,
          restructuring,   liquidation,   dissolution  or  other   extraordinary
          transaction  with  respect to the Company or any of its  subsidiaries,
          (iv) any acquisition of the securities or assets of any other business
          enterprise  by the  Company  or any of its  subsidiaries,  or (v)  any
          "solicitation" of "proxies" (as such terms are used in the proxy rules
          of the SEC);

               (b) form, join or in any way participate in a "group" (as defined
          under the 1934 Act) with  respect to the Company  (other than with any
          other Stockholder);

               (c) otherwise  act,  alone or in concert with others,  to seek to
          control  the  management,  the  Company  Board or the  policies of the
          Company,   including,   without  limitation,   by  (i)  initiating  or
          instituting a stockholder  solicitation for any such purpose,  or (ii)
          nominating or causing others to nominate or otherwise seeking to elect
          directors of the Company other than those nominated by the Board;

               (d) take any  action  which  might  force the  Company  to make a
          public announcement regarding any of the types of matters set forth in
          5(a) above;

               (e) enter into any  discussions  or  arrangements  with any third
          party with respect to any of the foregoing; or

               (f)  request  the  Company  to  amend,  waive  or  terminate  any
          provision of this Agreement (including this sentence).

        5.2.    Notwithstanding anything to the contrary in Section 5.1: (a) the
mere act of selling any Company Voting Securities beneficially owned by any of
the Stockholders shall not by itself be deemed to constitute the participation
in or assistance by any of the Stockholders with respect to any of the foregoing
provided such act is consistent with Section 6.5; (b) Mr. Kirk's exercise of his
rights,  or  fulfillment  of his  obligations,  as a

                                       6

<PAGE>

member of the Company Board while he is serving thereon shall not be a violation
of Section 5.1; and (c) Mr. Kirk may make a proposal that would otherwise be
prohibited by Section 5.1 provided it is made confidentially to the Company
Board.

6.      CERTAIN AGREEMENTS RELATING TO COMPANY VOTING SECURITIES

        Provided  that  the  Company  is not in  material  default  under  this
Agreement, the Stockholders agree, jointly and severally as follows:

        6.1.    At any meeting of the stockholders of the Company held at any
time between the date of this Agreement and the expiration of the Term, they
shall: (a) vote, or cause to be voted, all Company Voting Securities
beneficially owned by any of them as of the applicable record date for such
meeting in favor of the  election to the Company Board of the Persons nominated
by the Company Board for election to the Company Board at such meeting; and (b)
except as otherwise instructed by a vote of at least a majority of the members
of the Company Board, not vote, or cause to be voted, any such Company Voting
Securities in favor of the removal from the Company Board of any director or in
favor of any candidate or slate of candidates for election to the Company Board
not nominated by the Company Board.

        6.2.    At any meeting of the stockholders of the Company held at any
time between the date of this Agreement and the earlier to occur of (a) the
expiration of the Term or (b) Mr. Kirk's resignation from the Company Board (if
he is elected thereto), the Stockholders shall, with respect to any proposal to
be voted upon at such meeting other than the election of candidates to the
Company Board or the removal of any member of the Company Board, either (the
choice between the following alternatives being within the sole discretion of
the Stockholders): (i) vote, or cause to be voted, all Company Voting Securities
beneficially owned by any of them as of the  applicable  record date for such
meeting in accordance with the recommendation of at least a majority of the
Company Board with respect to such  proposal; or (ii) vote, or cause to be
voted, all such Company Voting Securities in the same proportion as the
percentage of votes cast by the other holders of Company Voting Securities in
favor of, against and abstaining from such proposal.

        6.3.    At any meeting of the stockholders of the Company held at any
time between the date of this Agreement and the earlier to occur of (a) the
expiration of the Term or (b) Mr. Kirk's resignation from the Company Board (if
he is elected thereto), the Stockholders shall cause all Company Voting
Securities beneficially owned by any of them or any of their respective
Affiliates, Associates or Representatives to be present, in person or by proxy,
so that all such Company Voting Securities can be counted for the purpose of
determining the presence of a quorum at each such meeting.

                                       7

<PAGE>

        6.4.    From the date of this Agreement until the earlier to occur of
(a) the expiration of the Term or (b) Mr. Kirk's resignation from the Company
Board (if he is elected thereto), none of the Stockholders, nor any of their
Affiliates, Associates or Representatives, shall, directly or indirectly,
Beneficially own any Company Voting Securities exceeding, in the aggregate
among all of the Stockholders and their respective  Affiliates, Associates and
Representatives, 7.2% of the then-outstanding Company Voting Securities.  Any
acquisitions of beneficial ownership of Company Voting Securities by any of the
Stockholders, or their respective Affiliates, Associates or Representatives,
during the period referred to in the immediately preceding sentence shall be
made in a manner consistent with the then-applicable policies of the Company
Board regarding compliance with the Securities Acts and transactions in
Company Voting Securities by members of the Company Board and their Affiliates
(collectively, the "Company  Policies") and in compliance with all applicable
laws.

        6.5.    From the date of this Agreement until the earlier to occur of
(a) the expiration of the Term or (b) Mr. Kirk's resignation from the Company
Board (if he is elected thereto),  none of the Stockholders shall dispose of any
Company Voting Securities they currently Beneficially own unless the Company
Board (through its Chairman) receives 2 business days prior written  notice of
the applicable Stockholder's intention with respect to the disposition,
including the details thereof (by way of example only, the number of Company
Voting Securities to be disposed of, and the proposed price and buyer or other
transferee or a statement of its intention to engage in open market sale);
provided, however, that the foregoing notice requirement shall not apply to
open-market sales by the Stockholders of less than 1% of the outstanding Company
Common Stock in the aggregate in any 90-day period provided such sales are
effected in accordance with the Company Policies.  Any disposition of beneficial
ownership of Company Voting Securities by any of the Stockholders during the
period referred to in the immediately preceding sentence shall be made in a
manner consistent with Company Policies and in compliance with all applicable
laws.

7.      SPECIAL RELEASES AND COVENANTS NOT TO SUE

        7.1.    The  Company: (a) fully releases, remises, exonerates forever
and unconditionally discharges each of the Stockholders and their respective
Affiliates, Associates, Representatives, employees, agents and advisors (each, a
"Stockholder  Releasee") from any and all liability and  responsibility  for any
and all Company  Claims (as  hereinafter  defined) and; (b) covenants and agrees
not to participate in, commence or permit (to the extent within its control) the
assertion or commencement of any demand, allegation,  litigation,  proceeding or
action relating to any Company Claim, and not to encourage,  assist or cooperate
with any  Person in  pursuing  or  asserting  any  Company  Claim,  against  any
Stockholder  Releasee.  As used in this  agreement,  "Company  Claim"  means any
actual or alleged liability,  claim, action, suit, cause of action,  obligation,
debt,

                                       8

<PAGE>

controversy, promise, contract, lien, judgement, account, reckoning, bond,
bill,  covenant,  agreement,  demand, of any kind or nature, loss, cost, damage,
penalty or expense (including,  without limitation,  reasonable  attorneys' fees
and expenses,  and the cost of investigation and litigation),  whether in law or
in equity,  whether known or unknown,  whether  matured or unmatured and whether
foreseen  or  unforeseen,  that  the  Company  may or  could  have had or now or
hereafter  may have,  for,  upon,  or by reason of, any  matter,  cause or thing
whatsoever  resulting from,  arising out of,  relating to,  connected in any way
with,  or alleged,  suggested  or mentioned in  connection  with,  (i) the Proxy
Contest or any part or aspect thereof, (ii) any action taken, or statement made,
in connection with the Proxy Contest,  (iii) the acquisition or ownership of any
shares of Company Common Stock by any of the Stockholder Releasees,  or (iv) any
action, failure to act, representation,  event, transaction, occurrence or other
subject matter resulting from, arising out of, relating to, connected in any way
with, or alleged, suggested or mentioned, in connection with the foregoing.

        7.2.    The Stockholders jointly and severally: (a) fully release,
revise, exonerate and forever and unconditionally discharge the Company and each
of its Affiliates, Associates, Representatives, employees, agents and advisors
(each, a "Company  Releasee") from any and all liability and  responsibility for
any and all Stockholder Claims (as hereinafter defined); and (b)covenant and
agree not to  participate in, commence or permit (to the extent within its
respective control) the assertion or commencement of any demand, allegation,
litigation, proceeding or action relating to any Stockholder Claim, and not to
encourage, assist or  cooperate  with any Person in pursuing or asserting any
Stockholder Claim against any Company Releasee.  As used in this Agreement,
"Stockholder Claim" means any actual or alleged liability, claim, action, suit,
cause of action, obligation, debt, controversy, promise, contract, lien,
judgment, account, reckoning, bond, bill, covenant, agreement, demand of any
kind or nature, loss, cost, damage, penalty or expense (including, without
limitation, reasonable attorneys' fees and expenses, and the costs of
investigation and litigation), whether in law or in equity, whether known or
unknown, whether matured or unmatured and whether foreseen or unforeseen, that
any Stockholder may or could have had or now or hereafter may have, for, upon,
or by reason of, any matter, cause or thing whatsoever resulting from, arising
out of, relating to, connected in any way with, or alleged, suggested or
mentioned in connection with, (i) the Proxy Contest or any part or aspect
thereof, (ii) any  action taken, or statement made, in connection with the Proxy
Contest, or (iii) any action, failure to act, representation, event,
transaction, occurrence or other subject matter resulting from, arising out of,
relating to, connected in any way with, or alleged, suggested or mentioned in
connection with the foregoing.

        7.3.    The Company, in connection with the release and covenant
contained in Section 7.1, and each of the  Stockholders, in connection with the
release and covenant contained in Section 7.2, each hereby waive the provisions
of 1542 of the California Civil

                                       9

<PAGE>

Code but only to the extent it applies to their respective releases contained in
the applicable such Section.  Section 1542 of the California Civil Code provides
as follows:

         A general  release does not extend the claims  which the creditor  does
         not know or suspect to exist in his favor at the time of executing  the
         release, which if known by him must have materially affected settlement
         with the debtor.

        7.4.    The Company expressly acknowledges that each Stockholder
Releasee that is not a  Stockholder is an intended third party beneficiary of
the release and covenant contained in Section 7.1 and the Stockholders jointly
and severally acknowledge that each Company Releasee other than the Company is
an intended third party beneficiary of the release and covenant contained in
Section 7.2.

8.      CERTAIN REPRESENTATIONS AND WARRANTIES

        8.1.    The Company represents and warrants to each of the Stockholders
that: (a) its execution, delivery and performance of this Agreement has been
approved by the Company Board and does not violate its Certificate of
Incorporation, Bylaws or any agreement to which it is a party; and (b) this
Agreement constitutes a valid and binding obligation of the Company, enforceable
against the Company in accordance with its terms, except as such enforcement may
be limited by bankruptcy, insolvency or similar laws affecting the enforcement
of creditors' rights generally.

        8.2.    The Stockholders jointly and severally  represent to the Company
that: (a) the execution, delivery and performance of this Agreement by RJK,
Kirkfield and the Plan have been approved by their respective managers, members,
administrators,  or other governing  bodies or authorities,  as the case may be,
and does not violate their respective  organizational  or constituent  document,
(b) their execution, delivery and performance of this Agreement does not violate
any agreement to which any of them is a party; (c) this Agreement  constitutes a
valid and binding obligation of each of them,  enforceable  against each of them
in  accordance  with its  terms,  except as such  enforcement  may be limited by
bankruptcy,  insolvency or similar laws affecting the  enforcement of creditors'
rights  generally;  (d) they have  consulted  with  counsel  of their  choice in
connection with their decision to enter into and be bound by this Agreement; and
(e) Recital A to this Agreement is a true  statement of their current  aggregate
beneficial ownership of Company Common Stock and, to their best knowledge, after
due inquiry, none of their respective Affiliates,  Associates or Representatives
Beneficially owns any other Company Voting Securities.

                                       10

<PAGE>

9.      MISCELLANEOUS

        9.1.    This Agreement constitutes the entire agreement of the parties
with respect to its subject  matter and supersedes any and all prior
representations, agreements or understandings, whether written or oral, between
or among any of them with respect to such subject matter.  This Agreement may be
amended only by a written agreement duly executed by the parties.

        9.2.    This Agreement shall be governed by, and construed in accordance
with, the laws of the State of Delaware  without regard to its conflict of law
principles.  Exclusive jurisdiction to resolve any dispute arising under or in
connection with this Agreement is hereby conferred on the Delaware Chancery
Court (or, if such Court determines that it lacks jurisdiction over the
particular dispute, any other applicable court of the State of Delaware) or, if
the dispute involves issues of federal law or over which the Delaware Chancery
Court (or such other court of the State of Delaware) lacks or declines
jurisdiction, on the United States Federal District Court for the District of
Delaware.  The Parties hereby submit to the exclusive jurisdiction of each of
such courts.

        9.3.    This Agreement may not be assigned by any Party without the
prior written consent of the other Parties.  This Agreement shall be binding
upon, and inure to the benefit of, the respective successors and permitted
assigns of the Parties.  Except as expressly set forth in Section 7.4, this
Agreement shall confer no rights or benefits upon any Person other than the
Parties.

        9.4.    Any  waiver by any Party of a breach of any provision of this
Agreement shall not be deemed to be a waiver of any other breach of such
provision or of any breach of any other provision of this Agreement.

        9.5.    This Agreement may be executed in counterparts, each of which
shall constitute an original but all of which shall together constitute a single
instrument.

        9.6.    The Stockholders jointly and severally covenant that they shall
each use their commercially reasonable efforts to cause the Stockholder Nominees
other than Mr. Kirk to comply with the provisions of Section 5 to the same
extent as if such other Stockholder Nominees were express parties thereto.

        9.7.    The Company shall reimburse the Stockholders for 50% of their
actual documented out-of-pocket costs in respect of: (a) fees and  expenses paid
and payable by them, in connection with services provided for the Proxy Contest,
to the law firm, public relations firm and proxy solicitation firm that have
advised them in connection with the Proxy Contest; and (b) amounts paid and
payable to ADP Proxy Services in respect of the dissemination of the written
materials issued by the Stockholders during the course of the Proxy Contest.

                                       11

<PAGE>

         9.8    Without Mr. Kirk's prior consent (which shall not be
unreasonably withheld), the Company shall not: (a) change the date on which the
2000 Annual Meeting is currently scheduled to convene; (b) hold the 2001 Annual
Meeting later than June 1, 2001; or (c) amend the Advance Notice Bylaws during
the Term.

                     [REST OF PAGE INTENTIONALLY LEFT BLANK]

                                       12

<PAGE>

         IN WITNESS  WHEREOF,  this  Agreement  has been executed by each of the
parties as of the date first above written.

SCIOS INC.                                      RANDAL J. KIRK

         /s/ Richard B. Brewer                   /s/ Randal J. Kirk
By:______________________________               _______________________________
         Richard B. Brewer,                     Randal J. Kirk
         President and Chief
         Executive Officer


                                                RJK, LLC

                                                    /s/ Randal J. Kirk
                                                By:____________________________
                                                   Randal J. Kirk
                                                   Manager



                                                KIRKFIELD, LLC


                                                    /s/ Randal J. Kirk
                                                By:____________________________
                                                   Randal J. Kirk
                                                   Manager


                                                THE KIRK FAMILY INVESTMENT PLAN

                                                   /s/ Randal J. Kirk
                                                By:____________________________
                                                   Randal J. Kirk, individually
                                                   and as attorney-in-fact for
                                                   each of Donna P. Kirk, Julian
                                                   P. Kirk, Martin G. Kirk and
                                                   Kellie Leigh Banks

                                       13

<PAGE>

                                                                     Exhibit 4.1

                          FORM OF JOINT PRESS RELEASE

                   [Intentionally omitted; see Exhibit 99.2]


                                       14



                                  [SCIOS LOGO]
                              820 West Maude Avenue
                               Sunnyvale, CA 94086
                                www.sciosinc.com

CONTACT:
Wendy Carhart                                           For Randal J. Kirk:
Scios Inc.                                              Caroline Gentile
408/616-8325                                            Kekst and Company
or                                                      212/521-4800
Stanley J. Kay
MacKenzie Partners, Inc.
212/929-5940

FOR IMMEDIATE RELEASE:

                 SCIOS AND R. J. KIRK AGREE TO END PROXY CONTEST

                  Parties Focused On Building Stockholder Value

SUNNYVALE,  CALIFORNIA  and  RADFORD,  VIRGINIA--January  31,  2000--Scios  Inc.
(NASDAQ:SCIO) and Randal J. Kirk jointly announced today a definitive  agreement
which  enables Scios  management to move forward with its business  strategy and
expands the board of directors,  if elected by  stockholders,  to one that will,
together with management,  report beneficial  ownership of nearly ten percent of
the company's fully diluted shares.

Under the  agreement,  which ends Mr. Kirk's proxy  solicitation  to elect a new
slate of directors,  Mr. Kirk will be added to the slate of candidates nominated
by the Scios Board for  election  as  directors  at the 2000  annual  meeting of
stockholders  to be held on  February  28,  2000.  This will raise the number of
Board  candidates to eight,  including the seven current Scios Board members who
are  standing  for  re-election.  If  elected,  Mr.  Kirk as  well as all  other
directors will serve for a one-year term.

Accordingly,  Mr. Kirk and certain entities he controls, which own approximately
5.2% of Scios'  outstanding  shares will vote their Scios shares in favor of the
Board's nominees at the upcoming annual meeting.

                                   -- more --
<PAGE>
                                                                January 31, 2000
                                                                          Page 2

Randal J. Kirk stated, "I strongly believe that there is substantial shareholder
value to be realized at Scios as evidenced by the size of my holdings,  and I am
pleased  to be  nominated  to a  slate  of this  caliber.  I am  convinced  that
Natrecor(R),  for example,  is a product with  extremely  attractive  commercial
potential, and that Scios' management should be in a position to devote its full
energies to obtaining  FDA approval for this product.  At the same time,  Scios'
offer to have me on its board will enable me, if elected, to work with the other
directors and management to build value for all Scios stockholders."

Donald B. Rice,  Scios'  Chairman,  and Richard B. Brewer,  President  and Chief
Executive  Officer,  said, "The priority of the board and management of Scios is
to achieve  enhanced value for all  stockholders.  This negotiated  agreement is
consistent  with that  priority.  By ending a  distractive  situation we can now
devote everyone's  energies to the business of growing Scios. Scios can now move
forward with a board that is strong in business  experience,  industry expertise
and  stockholder  representation.  We  believe  Mr.  Kirk can  bring a  valuable
perspective to the board."

Consistent with the agreement's spirit of cooperation, Mr. Kirk and his entities
have agreed to certain  "stand  still"  provisions.  Both  parties will file the
definitive  settlement  agreement  with  the  SEC  shortly  and  Scios  will  be
supplementing its proxy statement to add Mr. Kirk as a nominee to its Board.

Scios, Inc.

Scios is a biopharmaceutical company engaged in the discovery,  development, and
commercialization of novel human therapeutics.  Scios has commercial or research
and   development   relationships   with   Chiron   Corporation,    The   DuPont
Pharmaceuticals   Company,   Eli  Lilly  and   Company,   GenVec   Inc.,   Kaken
Pharmaceutical  Co., Ltd., and Novo Nordisk A/S of Denmark.  Scios'  Psychiatric
Sales and Marketing Division  successfully  markets seven psychiatric  products,
including co-promotion  arrangements with Janssen  Pharmaceutica's  Risperdal(R)
(risperidone)  and SmithKline  Beecham's  Paxil(R)  (paroxetine  hydrochloride).
Additional  information  on  Scios  is  available  at its web  site  located  at
www.sciosinc.com  and in the Company's  various  filings with the Securities and
Exchange Commission.

                                    -- end --



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