SCIOS INC
DEFA14A, 2000-02-01
PHARMACEUTICAL PREPARATIONS
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SCHEDULE 14A INFORMATION

Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934
(Amendment No. )

Filed by the Registrant /X/
Filed by a party other than the Registrant / /

Check the appropriate box:
/ / Preliminary Proxy Statement

/ /  Confidential,  for  Use  of the  Commission  Only  (as  permitted  by  Rule
     14a-6(e)(2))
/ / Definitive Proxy Statement
/X/ Definitive  Additional Materials

/ / Soliciting Material Pursuant to Section 240.14a-11(c) or Section
     240.14a-12

                                   Scios Inc.

- --------------------------------------------------------------------------------
                (Name of Registrant as Specified In Its Charter)

- --------------------------------------------------------------------------------
(Name of Person(s) Filing Proxy Statement, if other than the Registrant)

Payment of Filing Fee (Check the appropriate  box):
/X/ No fee required
/ / Fee computed on table below per Exchange  Act Rules  14a-6(i)(1)
     and 0-11

(1) Title of each class of securities to which transaction applies:

- ------------------------------------------------------------------------

(2) Aggregate number of securities to which transaction applies:

- ------------------------------------------------------------------------

(3) Per unit price or other underlying value of transaction computed pursuant to
Exchange  Act Rule  0-11  (set  forth the  amount  on which  the  filing  fee is
calculated and state how it was determined):

- ------------------------------------------------------------------------

(4) Proposed maximum aggregate value of transaction:

- ------------------------------------------------------------------------

(5) Total fee paid:

- ------------------------------------------------------------------------

/ / Fee paid previously with preliminary materials.

/    / Check box if any part of the fee is offset as provided  by  Exchange  Act
     Rule  0-11(a)(2)  and identify the filing for which the  offsetting fee was
     paid  previously.  Identify the previous filing by  registration  statement
     number, or the Form or Schedule and the date of its filing.

     (1) Amount Previously Paid:

     ------------------------------------------------------------------------

     (2) Form, Schedule or Registration Statement No.:

     ------------------------------------------------------------------------

     (3) Filing Party:

     -----------------------------------------------------------------------

     (4) Date Filed:

     ------------------------------------------------------------------------

<PAGE>

                               [SCIOS LETTERHEAD]



                                                                February 1, 2000



DEAR STOCKHOLDER:

         We are pleased to inform you that the proxy  contest  between Scios and
Randal J. Kirk has been resolved.

         On January 31, Scios signed a definitive  settlement agreement with Mr.
Kirk and certain entities he controls,  ending his proxy solicitation to elect a
new slate of  directors.  Under the  agreement,  Mr.  Kirk has been added to the
slate of candidates nominated by the Scios Board for election to a one-year term
at the 2000 annual meeting of  stockholders  to be held on February 28, 2000. In
return,  he has  withdrawn  his  nomination  and has agreed to  discontinue  all
solicitation  activities.  He has also agreed (if he is elected to the Board) to
certain  restrictions on his activities  related to Scios until at least 90 days
before next year's  annual  meeting and for a longer period if the Board decides
to renominate him for a second term next year.

         We are  convinced  that  this  negotiated  settlement  is in  the  best
interests of Scios and its  stockholders.  It enables  Scios  management to move
forward with its business strategy,  including the Natrecor(R)  clinical testing
and  approval  process.  Furthermore,  it  gives  Mr.  Kirk,  as  a  significant
stockholder,  an opportunity to work with the other  directors and management to
build value for all Scios stockholders.

         THE SCIOS BOARD HAS APPROVED THE  SETTLEMENT  AGREEMENT AND  RECOMMENDS
THAT YOU VOTE FOR ALL EIGHT NOMINEES AT THE ANNUAL MEETING.

         We are enclosing the following important documents for your information
in connection with the settlement:

          o    the joint press  release  issued by Scios and Mr. Kirk on January
               31, 2000;

          o    a  supplement  to  our  proxy  statement  containing   additional
               information  about the  settlement  agreement and the addition of
               Mr. Kirk as a Board nominee at the upcoming annual meeting; and

          o    A new  GOLD  proxy  card for your  use in  voting  for all  eight
               nominees.

<PAGE>

         If you  would  like to  review  the  complete  text  of the  settlement
agreement,  you can find it on file with the Securities and Exchange  Commission
as part of our Current  Report on Form 8-K dated  February 1, 2000. You can also
find it on our website located at www.sciosinc.com.

         WHETHER OR NOT YOU HAVE PREVIOUSLY  RETURNED A GOLD PROXY CARD TO US OR
A WHITE PROXY CARD TO MR. KIRK, WE ASK THAT YOU COMPLETE AND RETURN THE NEW GOLD
PROXY CARD  (WHICH IS ENCLOSED  AND IS POSTAGE  PRE-PAID IF MAILED IN THE UNITED
STATES).  THE WHITE PROXY CARD IS NO LONGER VALID FOR USE AT THE ANNUAL  MEETING
AND CANNOT BE USED TO VOTE FOR THE EIGHT BOARD NOMINEES, INCLUDING MR. KIRK.

                       On Behalf of the Board of Directors

                                   Sincerely,

/s/ Donald B. Rice                              /s/ Richard B. Brewer

DONALD B. RICE                                  RICHARD B. BREWER
CHAIRMAN OF THE BOARD                           PRESIDENT AND CHIEF
                                                EXECUTIVE OFFICER



                            IF YOU HAVE ANY QUESTIONS
                               OR NEED ASSISTANCE
                           COMPLETING YOUR PROXY CARD
                                  PLEASE CALL:
                            MACKENZIE PARTNERS, INC.
                                156 FIFTH AVENUE
                            NEW YORK, NEW YORK 10010
                          (212)929-5500 (CALL COLLECT)
                                       OR
                          CALL TOLL-FREE (800)322-2855

                                       2



                                  [SCIOS LOGO]
                              820 West Maude Avenue
                               Sunnyvale, CA 94086
                                www.sciosinc.com

CONTACT:

Wendy Carhart                                           For Randal J. Kirk:
Scios Inc.                                              Caroline Gentile
408/616-8325                                            Kekst and Company
or                                                      212/521-4800
Stanley J. Kay
MacKenzie Partners, Inc.
212/929-5940

FOR IMMEDIATE RELEASE:

                 SCIOS AND R. J. KIRK AGREE TO END PROXY CONTEST

                  Parties Focused On Building Stockholder Value

SUNNYVALE,  CALIFORNIA  and  RADFORD,  VIRGINIA--January  31,  2000--Scios  Inc.
(NASDAQ:SCIO) and Randal J. Kirk jointly announced today a definitive  agreement
which  enables Scios  management to move forward with its business  strategy and
expands the board of directors,  if elected by  stockholders,  to one that will,
together with management,  report beneficial  ownership of nearly ten percent of
the company's fully diluted shares.

Under the  agreement,  which ends Mr. Kirk's proxy  solicitation  to elect a new
slate of directors,  Mr. Kirk will be added to the slate of candidates nominated
by the Scios Board for  election  as  directors  at the 2000  annual  meeting of
stockholders  to be held on  February  28,  2000.  This will raise the number of
Board  candidates to eight,  including the seven current Scios Board members who
are  standing  for  re-election.  If  elected,  Mr.  Kirk as  well as all  other
directors will serve for a one-year term.

Accordingly,  Mr. Kirk and certain entities he controls, which own approximately
5.2% of Scios'  outstanding  shares will vote their Scios shares in favor of the
Board's nominees at the upcoming annual meeting.

                                   -- more --

<PAGE>

                                                                January 31, 2000
                                                                          Page 2

Randal J. Kirk stated, "I strongly believe that there is substantial shareholder
value to be realized at Scios as evidenced by the size of my holdings,  and I am
pleased  to be  nominated  to a  slate  of this  caliber.  I am  convinced  that
Natrecor(R),  for example,  is a product with  extremely  attractive  commercial
potential, and that Scios' management should be in a position to devote its full
energies to obtaining  FDA approval for this product.  At the same time,  Scios'
offer to have me on its board will enable me, if elected, to work with the other
directors and management to build value for all Scios stockholders."

Donald B. Rice,  Scios'  Chairman,  and Richard B. Brewer,  President  and Chief
Executive  Officer,  said, "The priority of the board and management of Scios is
to achieve  enhanced value for all  stockholders.  This negotiated  agreement is
consistent  with that  priority.  By ending a  distractive  situation we can now
devote everyone's  energies to the business of growing Scios. Scios can now move
forward with a board that is strong in business  experience,  industry expertise
and  stockholder  representation.  We  believe  Mr.  Kirk can  bring a  valuable
perspective to the board."

Consistent with the agreement's spirit of cooperation, Mr. Kirk and his entities
have agreed to certain  "stand  still"  provisions.  Both  parties will file the
definitive  settlement  agreement  with  the  SEC  shortly  and  Scios  will  be
supplementing its proxy statement to add Mr. Kirk as a nominee to its Board.

Scios, Inc.

Scios is a biopharmaceutical company engaged in the discovery,  development, and
commercialization of novel human therapeutics.  Scios has commercial or research
and   development   relationships   with   Chiron   Corporation,    The   DuPont
Pharmaceuticals   Company,   Eli  Lilly  and   Company,   GenVec   Inc.,   Kaken
Pharmaceutical  Co., Ltd., and Novo Nordisk A/S of Denmark.  Scios'  Psychiatric
Sales and Marketing Division  successfully  markets seven psychiatric  products,
including co-promotion  arrangements with Janssen  Pharmaceutica's  Risperdal(R)
(risperidone)  and SmithKline  Beecham's  Paxil(R)  (paroxetine  hydrochloride).
Additional  information  on  Scios  is  available  at its web  site  located  at
www.sciosinc.com  and in the Company's  various  filings with the Securities and
Exchange Commission.

                                    -- end --



                                  [SCIOS LOGO]

                                   SCIOS INC.
                              820 WEST MAUDE AVENUE
                               SUNNYVALE, CA 94086

          -------------------------------------------------------------

                          SUPPLEMENT TO PROXY STATEMENT
                                       FOR
                         ANNUAL MEETING OF STOCKHOLDERS
                                FEBRUARY 28, 2000

          -------------------------------------------------------------

GENERAL

         Scios Inc., a Delaware corporation (the "Company"),  hereby supplements
its proxy statement dated January 20, 2000 (the "Scios Proxy Statement") for its
Annual Meeting of Stockholders to be held at the Company's office located at 749
North Mary Avenue, Sunnyvale, California 94086 at 9:00 a.m. on February 28, 2000
and any adjournment or postponement of the annual meeting.

         Enclosed  with  this  Supplement  is a new GOLD  proxy  card for use by
stockholders in voting their shares of Common Stock at the annual meeting.

         AS INDICATED BELOW,  UNDER A RECENTLY-SIGNED  SETTLEMENT  AGREEMENT THE
BOARD OF DIRECTORS  HAS ADDED MR. RANDAL J. KIRK AS A BOARD NOMINEE FOR ELECTION
AT THE ANNUAL MEETING AND IT IS IMPORTANT THAT STOCKHOLDERS  COMPLETE AND RETURN
THE ENCLOSED NEW GOLD PROXY CARD TO ENSURE THAT THEIR SHARES ARE VOTED AS TO ALL
EIGHT NOMINEES.

         Neither  the  February  28,  2000 date of the annual  meeting,  nor the
January 11, 2000 record date for  determining  stockholders  entitled to vote at
the annual meeting, have changed.

         Capitalized  terms  used but not  defined in this  Supplement  have the
meanings given to them in the Scios Proxy Statement.

<PAGE>

SETTLEMENT  AGREEMENT;  TERMINATION OF PROXY CONTEST;  ADDITION OF MR. KIRK AS A
BOARD NOMINEE

         On January 31,  2000,  the Company  and the Kirk Group  entered  into a
Settlement Agreement (the "Settlement  Agreement") which ended the proxy contest
between the parties relating to the election of directors at the annual meeting.
Among other things,  the Settlement  Agreement provides for Mr. Kirk to be added
to the Board's slate of nominees for election to the Board at the annual meeting
(see "PROPOSAL NO. 1 - Election of Directors" below).

         THE  COMPANY  HAS FILED THE  SETTLEMENT  AGREEMENT  AS AN  EXHIBIT TO A
CURRENT REPORT ON FORM 8-K DATED FEBRUARY 1, 2000. THE FOLLOWING  SUMMARY OF THE
SETTLEMENT AGREEMENT IS QUALIFIED BY THE FULL TEXT OF THAT DOCUMENT.

         Under the Settlement Agreement,  Mr. Kirk has been added to the Board's
slate of nominees for election to a one-year term at this year's annual meeting,
increasing  the total  number of Board  nominees to eight  (including  the seven
existing  nominees of the Board, who are all current members of the Board).  The
Board has agreed to recommend the election of all eight nominees. The Kirk Group
has withdrawn its nomination of Mr. Kirk and six other Board  candidates and has
agreed to discontinue all efforts (direct and indirect) to solicit votes for its
nominees or otherwise to pursue the nomination.

         The  Settlement  Agreement  provides  that the Kirk Group will vote its
Company  shares in favor of the Board's  nominees and against the removal of any
director,  and not pursue any unsolicited  acquisition attempts or engage in any
proxy contest,  for a specified period (the "Term"). The length of the Term will
depend on whether Mr. Kirk is elected at this year's  annual  meeting and, if he
is, on whether  the Board  chooses to  re-nominate  him for next  year's  annual
meeting. If Mr. Kirk is not elected at this year's annual meeting, the Term will
expire at the conclusion of that meeting. If he is elected at that meeting,  the
Term will expire at the earliest to occur of:

          o    Mr. Kirk's resignation from the Board within 15 days of the Board
               deciding,  at a meeting required to be held no later than 90 days
               before  next  year's  annual   meeting,   that  he  will  not  be
               re-nominated  at that meeting,  in which event the  provisions of
               the Company's Bylaws  requiring  advance notice to be given, by a
               specified  date,  of  a   stockholder's   intention  to  nominate
               directors,  or propose other  business,  at an annual  meeting of
               stockholders  (the "Advance Notice Bylaws") will be waived to the
               extent  necessary to permit any or all of the members of the Kirk
               Group (but no other  person) to nominate one or more of their own
               candidates  for  election  to the  Board  at next  year's  annual
               meeting;

          o    the  conclusion  of next  year's  annual  meeting if Mr.  Kirk is
               re-nominated for election at that meeting but is not elected; or

                                       2

<PAGE>

          o    the later of (i) the 30th day prior to the  deadline  established
               by the Advance  Notice Bylaws for  nominations  of candidates for
               election to the Board at the 2002 annual meeting or (ii) the date
               of Mr. Kirk's  resignation from the Board, but in no event beyond
               the conclusion of that meeting.

         In addition,  during the Term (or until Mr. Kirk resigns from the Board
before the end of the Term, if he is elected), the Kirk Group:

          o    must vote all of its Company shares on all matters other than the
               election  or  removal of  directors  either (as it chooses in its
               sole  discretion)  in  accordance  with the  recommendation  of a
               majority of the Board or in the same proportion as shares held by
               the other stockholders are voted;

          o    may not increase its aggregate  ownership of Company shares above
               7.2%  and  must  effect  all  purchases  in  compliance  with all
               then-applicable  Company policies  regarding  compliance with the
               federal  securities  laws  and  transactions  in  Company  voting
               securities  by  members  of the Board and their  affiliates  (the
               "Company Policies"); and

          o    must give the  Company  prior  notice if it intends to dispose of
               any of its Company shares (except that open-market  sales of less
               than 1%, in the  aggregate,  in any 90-day period are not subject
               to  this  notice  requirement)  and  must  effect  all  sales  in
               compliance with the Company Policies.

         The Settlement  Agreement contains certain other provisions,  including
restrictions  on public  announcements,  mutual releases of claims in connection
with the proxy contest and related covenants not to sue, certain representations
and warranties,  and the Company's  agreement to reimburse 50% of certain of the
Kirk Group's actual documented  out-of-pocket costs in connection with the proxy
contest.  In  addition,  the Company has agreed that,  without Mr.  Kirk's prior
consent (not to be unreasonably  withheld),  it will not change the date of this
year's annual meeting,  hold next year's annual meeting later than June 1, 2001,
or amend the Advance Notice Bylaws during the Term.

         The Settlement  Agreement permits Mr. Kirk to exercise his rights,  and
fulfill his obligations, as a member of the Board while he is serving on it, and
to make  confidential  proposals  to the  Board,  without  violating  any of the
provisions summarized above.

PROPOSAL NO. 1 - ELECTION OF DIRECTORS

        The Company refers you  to the  section  of the  Scios  Proxy  Statement
captioned  "PROPOSAL NO. 1 - Election Of Directors"  for  information  about the
seven current  members of the Board who have  previously  been  nominated by the
Board for re-election at the annual meeting.

                                       3

<PAGE>

         In view of Mr. Kirk's  addition as an eighth  nominee,  and pursuant to
the procedure  set forth in the  Company's  Certificate  of  Incorporation,  the
number of directors (which had been reduced to seven to reflect the longstanding
retirement plans of one of the current Directors) has been changed back to eight
and a Board of eight (8) Directors  will be elected at the annual  meeting.  The
term of office of each person so elected as a Director will  continue  until the
next annual meeting or until a successor has been elected.

         Unless otherwise  instructed,  the proxy holders will vote the new GOLD
proxy cards received by them for the eight nominees.  HOWEVER,  IF A STOCKHOLDER
DOES NOT RETURN THE  ENCLOSED  NEW GOLD PROXY CARD (WHICH  CONTAINS THE NAMES OF
ALL EIGHT NOMINEES,  INCLUDING MR. KIRK),  THAT  STOCKHOLDER'S  SHARES CANNOT BE
COUNTED IN THE  ELECTION OF MR. KIRK BUT ONLY IN THE ELECTION OF THE OTHER SEVEN
NOMINEES,  WHETHER OR NOT THE STOCKHOLDER PREVIOUSLY RETURNED A WHITE PROXY CARD
TO THE KIRK GROUP. THE WHITE PROXY CARD IS NO LONGER VALID FOR USE AT THE ANNUAL
MEETING.

         The candidates receiving a plurality of the votes of the shares present
in person or  represented  by proxy at the meeting and  entitled to vote will be
elected. Each person nominated for election,  (including Mr. Kirk) has agreed to
serve if elected,  and management has no reason to believe that any nominee will
be unable to serve.

         Under the Advance Notice Bylaws, the deadline for nominating candidates
for election to the Board, or submitting  other business,  at the annual meeting
has passed. Accordingly, and because the Kirk Group has withdrawn its nomination
of its  candidates  for election to the Board,  under the Advance  Notice Bylaws
only the Board's  eight  nominees  may be  nominated  for election at the annual
meeting.  Since  the Kirk  Group has  agreed to vote its  shares in favor of all
eight nominees,  and in light of the fact that a plurality of the votes cast for
each  nominee  will  elect that  nominee  providing  a quorum is present  (which
requires  the  presence,  in person or by proxy,  of a  majority  of the  shares
outstanding on the record date), all eight nominees are expected to be elected.

         The following  information  has been provided by Mr. Kirk for inclusion
in this  Supplement  with  respect  to his  candidacy  for  election  as a Board
nominee.

         "Mr.  Kirk's  full name is Randal J.  Kirk.  He is 45 years of age.  He
         beneficially  owns 2,000,000  shares of Common Stock, or  approximately
         5.2%  of the  outstanding  Common  Stock  (see  note  (4) to the  table
         appearing  in the Scios Proxy  Statement  under the  caption  "SECURITY
         OWNERSHIP OF MANAGEMENT AND PRINCIPAL STOCKHOLDERS").  He has served as
         the Managing  Director of Third  Security,  LLC (an investment  banking
         firm) since 1999.  In addition,  he currently  serves in the  following
         capacities: Chairman of Lotus Biochemical Corporation (a pharmaceutical
         company) since 1996;  Manager of New River Management  Company,  L.L.C.
         (an investment  holding company) since 1996;  Chairman of BCCX, Inc. (a
         clinical  laboratory  management  company) since

                                       4

<PAGE>

         1998; Chairman of SFR, LLC (a real estate investment company) since
         1998; Chairman of Clinical Chemistry  Holdings,  Inc. (a diagnostic
         instrumentation and supplies company) since 1999; Chairman of Biopop
         Integration Group, Inc. (a systems integration company) since 1999; and
         Manager of Zhong Mei, LLC (an investment holding company) since 1999.
         Previously, he served as Chairman of General Injectables & Vaccines,
         Inc. (a pharmaceutical distributor) between 1994 and 1998 and as
         Chairman and Chief Executive Officer of  Biological & Popular Culture,
         Inc. (a holding company) between 1996 and 1998."



THE BOARD OF DIRECTORS HOPES THAT STOCKHOLDERS WILL ATTEND THIS MEETING. WHETHER
OR NOT YOU PLAN TO  ATTEND,  YOU ARE  ASKED TO  COMPLETE,  SIGN AND  RETURN  THE
ENCLOSED  NEW GOLD PROXY  CARD IN THE  ACCOMPANYING  ENVELOPE  (WHICH IS POSTAGE
PRE-PAID IF MAILED IN THE UNITED  STATES).  STOCKHOLDERS  WHO ATTEND THE MEETING
MAY VOTE THEIR SHARES  PERSONALLY  EVEN THOUGH THEY HAVE SENT IN THEIR  PROXIES.
PLEASE NOTE,  HOWEVER,  THAT IF YOUR SHARES ARE HELD OF RECORD BY A BROKER, BANK
OR OTHER  NOMINEE AND YOU WISH TO VOTE AT THE MEETING,  YOU MUST OBTAIN FROM THE
RECORD HOLDER A PROXY ISSUED IN YOUR NAME.



                                    By Order of the Board of Directors

                                    JOHN H. NEWMAN
                                    Secretary

February 1, 2000

                                       5



                          [FORM OF REVISED PROXY CARD]

                                                                  NEW GOLD PROXY

                                   SCIOS INC.
                         Annual Meeting of Stockholders
                           Monday, February 28, 2000
          This Proxy is Solicited on Behalf of the Board of Directors.


The undersigned  hereby appoints Richard B. Brewer and John H. Newman, or either
of them, each with full power of substitution, as proxies of the undersigned, to
attend the Annual  Meeting of  Stockholders  of Scios,  Inc.,  to be held at the
offices of the Company, 749 North Mary Avenue,  Sunnyvale,  CA 94086 on February
28, 2000 at 9:00 a.m. and at any adjournments or postponement  thereof,  to vote
the number of shares the  undersigned  would be entitled  to vote if  personally
present,  and to vote in their  discretion  upon  any  other  business  that may
properly  come before the meeting.

THIS PROXY WHEN PROPERLY  EXECUTED WILL BE VOTED IN THE MANNER DIRECTED  HEREIN.
IF NO DIRECTION IS MADE, THIS PROXY WILL BE VOTED FOR PROPOSALS 1 AND 2.


                   CONTINUED AND TO BE SIGNED ON REVERSE SIDE

<PAGE>
                                                                  NEW GOLD PROXY

X       PLEASE MARK VOTES
        AS IN THIS EXAMPLE.

        The Board of Directors recommends a vote "FOR" Proposals 1 and 2.

1.      ELECTION OF DIRECTORS:
        NOMINEES:
        Samuel H. Armacost      Richard B. Brewer       Randal J. Kirk
        Donald B. Rice          Charles A. Sanders      Solomon H. Snyder
        Burton E. Sobel         Eugene L. Step

                                                                FOR ALL NOMINEES

                                                           WITHHOLD ALL NOMINEES

             To withhold your vote on any nominee(s), write their name(s) below:

             ___________________________________________________________________

2.      To  ratify  the  selection  of  PricewaterhouseCoopers LLP as the
        Company's independent auditors for Fiscal 2000.

                                                     FOR     AGAINST     ABSTAIN

                    DATE:_______________________________________________________

                    SIGNATURE:__________________________________________________

                    TITLE OR AUTHORITY:_________________________________________

                    SIGNATURE (IF JOINT):_______________________________________

                    Please sign exactly as name appears. When shares are held by
                    joint tenants,  both should sign.  When signing as attorney,
                    as executor, administrator, trustee or guardian, please give
                    full title as such.  If a  corporation,  please sign in full
                    corporate name by President or other authorized  officer. If
                    a partnership, please sign in partnership name by authorized
                    person.


PLEASE  SIGN,  DATE,  AND RETURN  THIS  PROXY IN THE  ENVELOPE  PROVIDED,  WHICH
REQUIRES NO POSTAGE IF MAILED IN THE UNITED STATES.



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