LEHMAN BROTHERS INC//
SC 13D/A, 1997-08-27
SECURITY BROKERS, DEALERS & FLOTATION COMPANIES
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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13D
                                 Amendment No.3

                    Under the Securities Exchange Act of 1934

                       HOUSTON BIOTECHNOLOGY INCORPORATED
                                (Name of Issuer)

                          Common Stock, par value $.01
                         (Title of Class of Securities)

                                  441840105000
                                 (CUSIP Number)

                                 Karen C. Manson
                                    Secretary


             Lehman Brothers Holdings Inc. 3 World Financial Center,
                             24th Floor New York, NY
                                   10285 (212)
                           526-1936 (Name, Address and
                      Telephone Number of Person Authorized
                                       to


                       Receive Notice and Communications)

                                February 27, 1997

             (Date of Event which required Filing of This Statement)



If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  which is  subject of this  Schedule  13D,  and is filing  this
schedule because of Rule 13d-1(b)(3) or (4), check the following box [ ].

Check the following box if a fee is being paid with this statement [  ]. (A fee
is not required only if the reporting person (1) has a previous statement on
file reporting beneficial ownership of more than five percent of the class of
securities described in Item 1; and (2) has filed no amendment subsequent
thereto reporting beneficial ownership of five percent or less of such class.) 
(See Rule 13d-7).  NOT APPLICABLE





<PAGE>


CUSIP No.
441840105000

1)  Names of Reporting Person
     S.S. or I.R.S. Identification No. of Above Person

     Lehman Brothers Inc.
     13-2518466

2)  Check the Appropriate box if a Member of a Group (see instructions)

     (a)  [  ]
     (b)  [  ]

3)  SEC Use Only

4)  Source of Funds (see instructions)
     WC

5) Check Box if Disclosure of Legal Proceedings is Requires
     Pursuant to Items 2(d) or 2(E)
     [X]

6)  Citizenship or Place of Organization
      Delaware

     Number of Shares Beneficially Owned by Each Reporting Person With:

7)  Sole Voting Power
     -0-

8)  Shared Voting Power
      -0-

9)  Sole Dispositive Power
     -0-

10) Shared Dispositive Power
      -0-

11) Aggregate Amount Beneficially Owned by Each Reporting Person
      -0-

12) Check if the Aggregate Amount in Row (9) Excludes Certain Shares
      [ ]



13) Percent of Class Represented by Amount in Row 9
       0.00%

14) Type of Reporting Person
      BD/CO


<PAGE>



CUSIP No.
441840105000

1)  Names of Reporting Person
     S.S. or I.R.S. Identification No. of Above Person

     LB I Group Inc.
     13-2741778

2)  Check the Appropriate box if a Member of a Group (see instructions)

     (a)  [  ]
     (b)  [  ]


3)  SEC Use Only

4)  Source of Funds (see instructions)
     WC

5) Check Box if Disclosure of Legal Proceedings is Requires
     Pursuant to Items 2(d) or 2(E)
     [ ]

6)  Citizenship or Place of Organization
      Delaware

     Number of Shares Beneficially Owned by Each Reporting Person With:

7)  Sole Voting Power
     -0-

8)  Shared Voting Power
      -0-

9)  Sole Dispositive Power
     -0-

10) Shared Dispositive Power
      -0-

11) Aggregate Amount Beneficially Owned by Each Reporting Person
      -0-

12) Check if the Aggregate Amount in Row (9) Excludes Certain Shares
      [ ]

13) Percent of Class Represented by Amount in Row 9
       0.00%

14) Type of Reporting Person
      CO



<PAGE>


Schedule 13D

Item 1.  Security and Issuer

          No change.


Item 2.  Identity and Background

         This  statement is filed on behalf of the  following  entities
(the "Reporting Persons"):

          LB I Group Inc., a Delaware corporation ("LB I Group") 3 World
          Financial Center
          New York, NY 10285

          LB I Group, a holding company, is a wholly owned subsidiary of Lehman
          Brothers Inc. and successor by merger to Ophthalmic Research Services
          I Inc., Ophthalmic Research Services I Inc. and HBLP Acquisition Corp.

          Lehman Brothers Inc., a Delaware corporation ("LBI")
          3 World Financial Center
          New York, NY 10285

          LBI, a wholly owned subsidiary of Holdings, is a broker-dealer and 
          the parent of LB I Group.

          The  following  entity  is  a  control  person  (the  "Control
Person") of the Reporting Persons:

           Lehman Brothers Holdings Inc. ("Holdings")
           3 World Financial Center
           New York, NY 10285

           Holdings through its domestic and foreign subsidiaries is a full-line
           securities firm.  Holdings is the parent of Lehman Brothers Inc.

           The names,  residence or business addresses,  citizenships and
present principal occupations or employment of the senior executive officers and
directors of the Reporting Persons are set forth in Appendix A hereto.

           Except as stated in Appendix B hereto,  none of the  Reporting
Persons,  or to the best knowledge of the Reporting Persons,  the Control Person
or any of the  persons  listed in  Appendix  A hereto,  has during the last five
years (i) been convicted in a criminal proceeding  (excluding traffic violations
or similar  misdemeanors) or (ii) been party to a civil proceeding of a judicial
or  administrative  body of a  competent  jurisdiction  and as a result  of such
proceeding  was or is subject to a  judgment,  decree or final  order  enjoining
future  violations  of, or  mandating  activities  subject to,  federal or state
securities laws or finding any violation with respect to such laws.

Item 3.  Source of Funds or Other Consideration

                  No change.

Item 4.  Purpose of Transaction

                  Pursuant to an Agreement and Plan of Merger dated December 28,
1996  among  Medarex,  Inc.,  a  New  Jersey  corporation  ("Medarex"),  Medarex
Acquisition Corp., a Delaware corporation and direct wholly-owned  subsidiary of
Medarex  ("Medarex Sub"),  and Houston  Biotechnology  Incorporated,  a Delaware
corporation  ("HBI"),  upon the merger of Medarex Sub,  with and into HBI,  each
outstanding  share of HBI common stock was  converted  into the right to receive
0.182 shares of Medarex  common  stock.  HBI warrants and options to acquire HBI
common stock were converted into warrants and options for Medarex common stock.

                  LB I Group  owned  500,341  shares of common  stock of HBI and
517,019  warrants  to  acquire  HBI common  stock.  As a result of the merger on
February 27, 1997, LB I Group acquired  91,062 shares of common stock of Medarex
and 94,097  warrants to acquire  Medarex common stock.  Such shares and warrants
are held directly by LB I Group. Holdings and LBI are deemed to beneficially own
the Medarex shares held by LB I Group.

Item 5.  Interest in Securities of the Issuer

                  (a)      See Item 4.

                  (b)      See Item 4.

                  (c) Except as described above,  there were no purchases and/or
sales of Common Stock effected during the past 60 days by the Reporting  Persons
or, to their  knowledge,  the Control  Person or any person listed in Appendix A
hereto.

                  (d) Neither the Reporting Persons nor, to their knowledge, the
Control  Person or any of the persons  listed in Appendix A hereto  knows of any
other  person who has the right to receive or the power to direct the receipt of
dividends  from,  or the  proceeds  form the sale of, any shares of Common Stock
beneficially owned by the Reporting Persons.

                  (e)      As of February 27, 1997 the Reporting Persons have 
ceased to be the beneficial owners  of more  than 5% of the class of securities
covered by this report.


Item 6.  Contracts, Arrangements, Understandings or Relationships with Respect
to Securities of the Issuer.

                  See Item 4.

Item 7.     Material to be Filed as Exhibits.

                      Agreement and Plan of Merger, dated as of December 18, 
1996, among Medarex, Medarex Sub and HBI (incorporated by reference to Exhibit
1.3 to Registration  Statement File No. 333-20119)

<PAGE>





                                   SIGNATURES


After  reasonable  inquiry and to the best of my knowledge and belief, I certify
that the information set forth in this statement is true, complete and correct.


Dated:  February 27, 1997


                              LEHMAN BROTHERS INC.
                              By:  /s/ Karen C. Manson
                              --------------------
                              Name: Karen C. Manson
                              Title:    Vice President and
                                        Secretary

                               LB I GROUP INC.
                               By:  /s/ Karen C. Manson
                               ---------------------
                               Name: Karen C. Manson
                               Title:    Secretary





<PAGE>


                                                           APPENDIX A

                          LEHMAN BROTHERS HOLDINGS INC.

                               BOARD OF DIRECTORS


NAME / TITLE                                        BUSINESS ADDRESS

Michael L. Ainslie                           Lehman Brothers Holdings Inc.
Private Investor and former                     3 World Financial Center
President and Chief Executive                   New York, New York 10285
Officer of Sotheby's Holdings

John F. Akers                                Lehman Brothers Holdings Inc.
Retired Chairman of                             3 World Financial Center
International Business Machines                 New York, New York 10285
Corporation

Roger S. Berlind                             Lehman Brothers Holdings Inc.
Theatrical Producer                             3 World Financial Center
                                                New York, New York 10285

Thomas H. Cruikshank                         Lehman Brothers Holdings Inc.
Retired Chairman and Chief                      3 World Financial Center
Executive Officer of Halliburton                 New York, New York 10285
Company

Richard S. Fuld, Jr.                           Lehman Brothers Holdings Inc.
Chairman and Chief Executive                     3 World Financial Center
Officer of                                          New York, NY 10285
Lehman Brothers Holdings Inc.

Katsumi Funaki*                                Lehman Brothers Holdings Inc.
Senior General Manager of                        3 World Financial Center
International Business of the                       New York, NY 10285
Finance and Investment Planning
Office of Nippon Life

Henry Kaufman                                  Lehman Brothers Holdings Inc.
President of Henry Kaufman &                     3 World Financial Center
Company, Inc.                                       New York, NY 10285

John D. Macomber                               Lehman Brothers Holdings Inc.
Principal of JDM Investment Group                3 World Financial Center
                                                    New York, NY 10285

Dina Merrill                                   Lehman Brothers Holdings Inc.
Actress and Director and Vice                    3 World Financial Center
Chairman of RKO Pictures, Inc.                     New York, NY 10285

Hideichiro Kobayashi*                        Lehman Brothers Holdings Inc.
General Manager for the Americas                3 World Financial Center
of Nippon Life                                     New York, NY 10285



                          LEHMAN BROTHERS HOLDINGS INC.

                               EXECUTIVE OFFICERS


NAME / TITLE                                          BUSINESS ADDRESS

Richard S. Fuld, Jr.                             Lehman Brothers Holdings Inc.
Chairman and Chief Executive Officer               3 World Financial Center
of Lehman Brothers Holdings Inc.                      New York, NY 10285


Jeremiah M. Callaghan                          Lehman Brothers Holdings Inc.
Chief of Operations and Technology                3 World Financial Center
                                                     New York, NY 10285

John L. Cecil
Chief Administrative Officer                   Lehman Brothers Holdings Inc.
                                                  3 World Financial Center
                                                     New York, NY 10285

Thomas A. Russo                                Lehman Brothers Holdings Inc.
Chief Legal Officer                               3 World Financial Center
                                                     New York, NY 10285

Charles B. Hintz                               Lehman Brothers Holdings Inc.
Chief Financial Officer                           3 World Financial Center
                                                     New York, NY 10285

- -----
All above individuals are citizens of the United States except those individuals
with an * who are citizens of Japan.


<PAGE>


                              LEHMAN BROTHERS INC.

                               BOARD OF DIRECTORS



NAME                                                BUSINESS ADDRESS

Roger S. Berlind                                  Lehman Brothers Inc.
Theatrical Producer                             3 World Financial Center
                                                New York, New York 10285

Philip Caldwell                                   Lehman Brothers Inc.
Senior Managing Director                        3 World Financial Center
                                                New York, New York 10285

Howard L. Clark, Jr.                              Lehman Brothers Inc.
Vice Chairman                                   3 World Financial Center
                                                New York, New York 10285

Frederick Frank                                   Lehman Brothers Inc.
Vice Chairman                                   3 World Financial Center
                                                 New York, New York 10285

Richard S. Fuld, Jr.                               Lehman Brothers Inc.
Chairman and Chief Executive                     3 World Financial Center
Officer of Lehman Brothers Holdings                 New York, NY 10285
Inc.


Charles B. Hintz                                   Lehman Brothers Inc.
Chief Financial Officer                          3 World Financial Center
                                                    New York, NY 10285

Bruce R. Lakefield                                 Lehman Brothers Inc.
Director of Lehman Brothers Inc.                 3 World Financial Center
                                                    New York, NY 10285


Sherman R. Lewis, Jr.                              Lehman Brothers Inc.
Vice Chairman                                    3 World Financial Center
                                                    New York, NY 10285


Mel A. Shaftel                                     Lehman Brothers Inc.
Vice Chairman                                    3 World Financial Center
                                                    New York, NY 10285

- -----
Above individuals are citizens of the United States.






                              LEHMAN BROTHERS INC.

                               EXECUTIVE OFFICERS


NAME / TITLE                                          BUSINESS ADDRESS

Richard S. Fuld, Jr.                             Lehman Brothers Holdings Inc.
Chairman and Chief Executive Officer               3 World Financial Center
of Lehman Brothers Holdings Inc.                      New York, NY 10285

Jeremiah M. Callaghan                          Lehman Brothers Holdings Inc.
Chief of Operations and Technology                3 World Financial Center
                                                     New York, NY 10285

John L. Cecil                                       Lehman Brothers Inc.
Chief Administrative Officer                      3 World Financial Center
                                                     New York, NY 10285

Charles B. Hintz                                    Lehman Brothers Inc.
Chief Financial Officer                           3 World Financial Center
                                                     New York, NY 10285

Thomas A. Russo                                     Lehman Brothers Inc.
Chief Legal Officer                               3 World Financial Center
                                                     New York, NY 10285

- -----
Above individuals are citizens of the United States.

<PAGE>



                                 LB I GROUP INC.

                               BOARD OF DIRECTORS


NAME                                                  BUSINESS ADDRESS

Eliot Fried                                         Lehman Brothers Inc.
Director                                          3 World Financial Center
                                                     New York, NY 10285

David Goldfarb                                      Lehman Brothers Inc.
Director                                          3 World Financial Center
                                                     New York, NY 10285

Allan S. Kaplan                                     Lehman Brothers Inc.
Director                                          3 World Financial Center
                                                     New York, NY 10285


- -----
Above individuals are citizens of the United States.

<PAGE>



                                                                APPENDIX B

Fulco v.  Continental  Cablevision.  This civil action was brought in the United
States District Court for the District of Massachusetts  alleging a violation of
Rule 10b(5) for a material  omission in the  disclosure  documents  related to a
1989 partnership  roll-up in which Shearson Lehman Brothers  rendered a fairness
opinion.  The jury rendered a verdict in 1993 jointly  against  Shearson  Lehman
Brothers and Continental  Cablevision,  the issuer, for a total of $4.6 million.
The case was settled shortly thereafter.

Lehman Brothers has been involved in a number of civil proceedings which concern
matters arising in connection with the conduct of its business.  Certain of such
proceedings  have  resulted  in  findings  of  violation  of  federal  or  state
securities  laws.  Each of these  proceedings  was  settled  by Lehman  Brothers
consenting to the entry of an order without admitting or denying the allegations
in the  complaint.  All of such  proceedings  are reported and summarized in the
Schedule D to Lehman  Brother's  Form BD filed with the  Securities and Exchange
Commission, which descriptions are hereby incorporated by reference.





<PAGE>


                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13D
                    Under the Securities Exchange Act of 1934
                                (Amendment No. 2)

                       HOUSTON BIOTECHNOLOGY INCORPORATED
                                (Name of Issuer)

                     Common Stock, par value $.01 per share
                         (Title of Class of Securities)

                                  441840105000
                                 (CUSIP Number)

                                 Karen C. Manson
                                    Secretary
                              Lehman Brothers Inc.
                        2 World Trade Center, 15th Floor
                            New York, New York 10048
                                 (212) 528-5772
            (Name, Address and Telephone Number of Person Authorized
                      to Receive Notice and Communications)

                                   May 3, 1994
             (Date of Event which Required Filing of This Statement)

If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  which is the subject of this  Schedule 13D, and is filing this
schedule because of Rule 13d-l(b)(3) or (4), check the following box [ ].

Check the following box if a fee is being paid with the statement [ ]. (A fee is
not required only if the reporting  person (1) has a previous  statement on file
reporting  beneficial  ownership  of more  than  five  percent  of the  class of
securities  described  in Item 1;  and (2) has  filed  no  amendment  subsequent
thereto reporting  beneficial  ownership of five percent or less of such class.)
(See Rule 13d-7).


<PAGE>


SCHEDULE 13D

CUSIP NO. 441840105000

1.     Name of Reporting Person
       S.S. or I.R.S. No. of Above Person

       Lehman Brothers Inc.

2.     Check the Appropriate Box if a Member of a Group (see instructions)

       (a)     [     ]
       (b)     [     ]

3.     SEC Use Only

4.     Source of Funds (see instructions)

       WC

5.     Check Box if Disclosure of Legal Proceedings is Required Pursuant to 
       Items 2(d) or 2(E)

       [X]

6.     Citizenship or Place of Organization

       Delaware

7.     Number of Shares Beneficially Owned by Each Reporting Person with Sole 
       Voting Power

       3,558

8.     Number of Shares Beneficially Owned by Each Reporting Person with Shared
       Voting Power

       0

9.     Number of Shares Beneficially Owned by Each Reporting Person with Sole
       Dispositive Power

       3,558

10.    Number of Shares Beneficially Owned by Each Reporting Person with Shared
       Dispositive Power

       0

11.    Aggregate Amount Beneficially Owned by Each Reporting Person

       3,558

12.    Check Box if the Aggregate Amount in Row (11) Excludes Certain Shares
       (see instructions)

       [    ]

13.    Percent of Class Represented by Amount in Row (11)

       .06 %

14.    Type of Reporting Person (see instructions)

       BD, CO

<PAGE>


SCHEDULE 13D

CUSIP NO. 441840105000

1.     Name of Reporting Person
       S.S. or I.R.S. No. of Above Person

       Ophthalmic Research Services I Inc.

2.     Check the Appropriate Box if a Member of a Group (see instructions)

       (a)   [    ]
       (b)   [    ]

3.     SEC Use Only

4.     Source of Funds (see instructions)

       WC

5.     Check Box if Disclosure of Legal Proceedings is Required Pursuant to
       Items 2(d) or 2(E)

       [     ]

6.     Citizenship or Place of Organization

       Delaware

7.     Number of Shares Beneficially Owned by Each Reporting Person with Sole
       Voting Power

       40,429

8.     Number of Shares Beneficially Owned by Each Reporting Person with Shared
       Voting Power

       0

9.     Number of Shares Beneficially Owned by Each Reporting Person with Sole
       Dispositive Power

       40,429

10.    Number of Shares Beneficially Owned by Each Reporting Person with Shared
       Dispositive Power

       0

11.    Aggregate Amount Beneficially Owned by Each Reporting Person

       40,429

12.    Check Box if the Aggregate Amount in Row (11) Excludes Certain Shares
       (see instructions)

       [    ]

13.    Percent of Class Represented by Amount in Row (11)

       .66%

14.    Type of Reporting Person (see instructions)

       CO


<PAGE>


SCHEDULE 13D

CUSIP NO. 44184010500.0

1.     Name of Reporting Person
       S.S. or I.R.S. No. of Above Person

       Ophthalmic Research Services II Inc.

2.     Check the Appropriate Box if a Member of a Group (see instructions)

       (a)   [    ]
       (b)   [    ]

3.     SEC Use Only

4.     Source of Funds (see instructions)

       WC

5.     Check Box if Disclosure of Legal Proceedings is Required Pursuant to 
       Items 2(d) or 2(E)

       [    ]

6.     Citizenship or Place of Organization

       Delaware

7.     Number of Shares Beneficially Owned by Each Reporting Person with Sole
       Voting Power

       3,676

8.     Number of Shares Beneficially Owned by Each Reporting Person with Shared
       Voting Power

       0

9.     Number of Shares Beneficially Owned by Each Reporting Person with Sole
       Dispositive Power

       3,676

10.    Number of Shares Beneficially Owned by Each Reporting Person with Shared
       Dispositive Power

       0

11.    Aggregate Amount Beneficially Owned by Each Reporting Person

       3,676

12.    Check Box if the Aggregate Amount in Row (11) Excludes Certain Shares
       (see instructions)

       [    ]

13.    Percent of Class Represented by Amount in Row (11)

       .05%

14.    Type of Reporting Person (see instructions)

       CO


<PAGE>


SCHEDULE 13D

CUSIP NO. 441840105000

1.     Name of Reporting Person
       S.S. or I.R.S. No. of Above Person

       HBLP Acquisition Corp.

2.     Check the Appropriate Box if a Member of a Group (see instructions)

       (a)     [   ]
       (b)     [   ]

3.     SEC Use Only

4.     Source of Funds (see instructions)

       WC

5.     Check Box if Disclosure of Legal Proceedings is Required Pursuant to
       Items 2(d) or 2(E)

       [   ]

6.     Citizenship or Place of Organization

       Delaware

7.     Number of Shares Beneficially Owned by Each Reporting Person with Sole
       Voting Power

       969,697

8.     Number of Shares Beneficially Owned by Each Reporting Person with Shared
       Voting Power

       0

9.     Number of Shares Beneficially Owned by Each Reporting Person with Sole
       Dispositive Power

       969,697

10.    Number of Shares Beneficially Owned by Each Reporting Person with Shared
       Dispositive Power

       0

11.    Aggregate Amount Beneficially Owned by Each Reporting Person

       969,697

12.    Check Box if the Aggregate Amount in Row (11) Excludes Certain Shares 
       (see instructions)

       [   ]

13.    Percent of Class Represented by Amount in Row (11)

       15.75 %

14.    Type of Reporting Person (see instructions)

       CO


<PAGE>


Item 1.    Security and Issuer.

The class of equity  securities  to which this  statement  relates is the Common
Stock, par value $.01 per share (the "Common Stock"),  of Houston  Biotechnology
Incorporated,  a  Delaware  corporation  (the  "Company").  The  address  of the
principal  executive  offices of the Company is 3608 Research Forest Drive,  The
Woodlands, Texas 77381.

Item 2.    Identity and Background.

This  statement is filed on behalf of the  following  entities  (the  "Reporting
Persons"):

           Lehman Brothers Inc., a Delaware corporation ("LB")
           3 World Financial Center
           200 Vesey Street
           New York, N.Y. 10285
           LB is a full-line securities firm.

           Ophthalmic Research Services I Inc., Delaware corporation ("ORS I")
           3 World Financial Center
           200 Vesey Street
           New York, N.Y. 10285
           The sole business of ORS I is to hold the stock of the Company.

           Ophthalmic Research Services II Inc., a Delaware corporation 
           ("ORS II")
           3 World Financial Center
           200 Vesey Street
           New York, N.Y. 10285
           The sole business of ORS II is to hold the stock of the Company.

           HBLP Acquisition Corp., a Delaware corporation ("HBLP")
           3 World Financial Center
           200 Vesey Street
           New York, N.Y. 10285
           The sole business of HBLP is to hold the stock of the Company.

The  following  entities  are control  persons  (the  "Control  Persons") of the
Reporting Persons:

           LB I Group  Inc.,  a  Delaware  corporation  ("LB I  Group")  3 World
           Financial Center 200 Vesey Street
           New York, N.Y. 10285
           LB I Group is a holding company and the parent of ORS I and ORS II.

           Lehman Brothers Holdings Inc., a Delaware corporation ("Holdings")
           3 World Financial Center
           200 Vesey Street
           New York, N.Y. 10285

Holdings through its domestic and foreign subsidiaries is a full-line securities
firm. It is the immediate parent of LB, HBLP and LB I Group.

<PAGE>


The names,  residence or business addresses,  citizenships and present principal
occupations  or  employment  of the  executive  officers  and  directors  of the
Reporting Persons and the Control Persons are set forth in Appendix A hereto.

Except as stated in Appendix B hereto, none of the Reporting Persons, or, to the
best  knowledge  of the  Reporting  Persons,  the Control  Persons or any of the
persons  listed in  Appendix  A hereto  has  during the last five years (i) been
convicted in a criminal  proceeding  (excluding  traffic  violations  or similar
misdemeanors)  or (ii)  been a party  to a civil  proceeding  of a  judicial  or
administrative body of competent jurisdiction and as a result of such proceeding
was or is  subject  to a  judgment,  decree  or  final  order  enjoining  future
violations of, or mandating  activities  subject to, federal or state securities
laws or finding any violation with respect to such laws.

Item 3.    Source of Funds or Other Consideration.

In May, 1994, the Reporting  Persons  received a distribution  of one additional
warrant for each share of Common Stock held  pursuant to the terms of the Rights
Offering.  As a consequence,  the Reporting Persons now beneficially own a total
of 500,341 shares of Common Stock and 517,019 Warrants.

Item 4.    Purpose of the Transaction.

No change.

Item 5.    Interest in Securities of the Issuer.

            (a) The  aggregate  beneficial  ownership  of  Common  Stock  of the
                Reporting  Persons  and,  to  their  knowledge,  of the  Control
                Persons and persons  listed in Appendix A hereto is set forth in
                Appendix C hereto.

           (b)  The  Reporting  Persons  and,  to their  knowledge,  the Control
                Persons  and each  person  listed in  Appendix A hereto have the
                power  to  vote  and   dispose  of  all  of  the  Common   Stock
                beneficially  owned by such  person as set forth in  Appendix  C
                hereto.

           (c)  Except as described above,  there were no purchases and sales of
                Common Stock  effected  during the past 60 days by the Reporting
                Persons  or, to their  knowledge,  the  Control  Persons  or any
                person listed in Appendix A hereto.

           (d)  Neither  the  Reporting  Persons  nor, to their  knowledge,  the
                Control  Persons  or any of the  persons  listed in  Appendix  A
                hereto knows of any other person who has the right to receive or
                the  power to direct  the  receipt  of  dividends  from,  or the
                proceeds   from  the  sale  of,  any  shares  of  Common   Stock
                beneficially owned by the Reporting Persons.

           (e)  Not Applicable.

Item 6.    Contracts, Arrangements, Understandings or Relationships with Respect
           to Securities of the Issuer.

No change.

Item 7.    Material to be Filed as Exhibits.

None.


<PAGE>


                                   SIGNATURES

After  reasonable  inquiry and to the best of my knowledge and belief, I certify
that the information set forth in this statement is true, complete and correct.

Dated:  September 9, 1994

                                LEHMAN BROTHERS INC.

                                By:
                                              Name:  Karen C. Manson
                                              Title:  Senior Vice President

                                OPHTHALMIC RESEARCH SERVICES I INC.

                                By:
                                              Name:  Karen C. Manson
                                              Title:  Secretary

                                OPHTHALMIC RESEARCH SERVICES II INC.

                                By:
                                              Name:  Karen C. Manson
                                              Title:  Secretary

                                HBLP ACQUISITION CORP.

                                By:
                                             Name:  Karen C. Manson
                                             Title:  Secretary



<PAGE>


                                   APPENDIX A

DIRECTORS AND EXECUTIVE OFFICERS OF REPORTING PERSONS AND CONTROL PERSONS

REPORTING PERSONS:

LEHMAN BROTHERS INC.

Directors:

           Roger S. Berlind
           USA
           Berlind Productions
           10 East 53rd Street
           30th Floor
           New York, New York
           Private Investor

           Philip Caldwell
           USA
           Lehman Brothers Inc.
           3 World Financial Center
           19th Floor
           New York, New York 10285

           Richard S. Fuld, Jr.
           USA
           Lehman Brothers Inc.
           3 World Financial Center
           New York, New York 10285
           Chairman and Chief Executive Officer of Lehman Brothers Inc.

           Sherman R. Lewis, Jr.
           USA
           Lehman Brothers Inc.
           3 World Financial Center
           New York, New York 10285
           Vice Chairman of Lehman Brothers Inc.

           David Marcus
           USA
           Lehman Brothers Inc.
           3 World Financial Center
           19th Floor
           New York, New York 10285
           Managing Director and General Counsel of Lehman Brothers Inc.

<PAGE>

           Robert Matza
           USA
           Lehman Brothers Inc.
           3 World Financial Center
           6th Floor
           New York, New York 10285
           Managing Director and Chief Financial Officer of Lehman Brothers Inc.

           T. Christopher Pettit
           USA
           Lehman Brothers Inc.
           3 World Financial Center
           10th Floor
           New York, New York 10285
           President and Chief Operating Officer of Lehman Brothers

           Malcolm Wilson
           USA
           Kent, Hazzard, Jaeger, Greer, Wilson & Fay
           50 Main Street
           White Plains, New York 10606-1920
           Counsel to Kent, Hazzard, Jaeger, Greer, Wilson & Fay

Executive Officers who are not Directors:

           T. Anthony Brooks
           USA
           Managing Director
           Lehman Brothers Inc.
           3 World Financial Center, 6th Floor
           New York, NY 10285

           Jeremiah M. Callaghan
           USA
           Managing Director
           Lehman Brothers Inc.
           3 World Financial Center, 8th Floor
           New York, NY 10285

           James A. Carbone
           USA
           Managing Director
           Lehman Brothers Inc.
           3 World Financial Center, 9th Floor
           New York, NY 10285

<PAGE>

           John L. Cecil
           USA
           Chief Administrative Officer
           Lehman Brothers Inc.
           3 World Financial Center, 8th Floor
           New York, NY 10285

           Ronald L. Gallatin
           USA
           Managing Director
           Lehman Brothers Inc.
           3 World Financial Center, 10th Floor
           New York, NY 10285

           Robert E. Genirs
           USA
           Managing Director
           Lehman Brothers Inc.
           3 World Financial Center, 10th Floor
           New York, NY 10285

           Joseph M. Gregory
           USA
           Managing Director
           Lehman Brothers Inc.
           3 World Financial Center, 9th Floor
           New York, NY 10285

           Bruce R. Lakefield
           USA
           Managing Director
           Lehman Brothers Inc.
           3 World Financial Center
           7th Floor
           New York, New York 10285

           Stephen M. Lessing
           USA
           Managing Director
           Lehman Brothers Inc.
           3 World Financial Center
           9th Floor
           New York, New York 10285

<PAGE>

           Thomas A. Russo
           USA
           Managing Director
           Lehman Brothers Inc.
           3 World Financial Center
           10th Floor
           New York. New York 10285

           Mel A. Shaftel
           USA
           Managing Director
           Lehman Brothers Inc.
           3 World Financial Center
           18th Floor
           New York, New York 10285

           Steven Spiegel
           USA
           Managing Director
           Lehman Brothers Inc.
           3 World Financial Center
           7th Floor
           New York, New York 10285

           Thomas H. Tucker
           USA
           Managing Director
           Lehman Brothers Inc.
           3 World Financial Center
           7th Floor
           New York, New York 10285

           C. Daniel Tyree
           USA
           Managing Director
           Lehman Brothers Inc.
           3 World Financial Center
           7th Floor
           New York, New York 10285

           Paul D. Williams
           USA
           Managing Director
           Lehman Brothers Inc.
           3 World Financial Center
           7th Floor
           New York, New York 10285


<PAGE>


                       Ophthalmic Research Services I Inc.
<TABLE>
<CAPTION>
           Name                    Office                 Occupation                    Address              Citizenship

<S>                                <C>                      <C>                     <C>                          <C>      
Ron Hiram                   President, Chief       Managing Director,         3 World Financial Center           USA
                            Financial Officer      Lehman Brothers Inc.       New York, NY 10285


Karen C. Manson             Secretary              Senior Vice President,     2 World Trade Center               USA
                                                   Lehman Brothers Inc.       New York, NY 10048


Thomas E. Gengler, Jr.      Assistant Treasurer    Managing Director,         3 World Financial Center           USA
                                                   Lehman Brothers Inc.       New York, NY 10285


Joseph L. Ternullo          Assistant Treasurer    Tax Manager, The Boston    3 World Financial Center           USA
                                                   Company Advisors Limited   New York, NY 10285
                                                   Partnerships
                                                   Administration


Eileen M. Bannon            Assistant Secretary    Assistant Secretary,       2 World Trade Center               USA
                                                   Lehman Brothers Inc.       New York, NY 10048


Madeline Shapiro            Assistant Secretary    Assistant Secretary,       2 World Trade Center               USA
                                                   Lehman Brothers Inc.       New York, NY 10048

</TABLE>


<PAGE>
                      Ophthalmic Research Services II Inc.
<TABLE>
<CAPTION>
           Name                    Office                 Occupation                    Address              Citizenship

<S>                                <C>                      <C>                     <C>                          <C>    
Ron Hiram                   President, Chief       Managing Director,         3 World Financial Center           USA
                            Financial Officer      Lehman Brothers Inc.       New York, NY 10285


Karen C. Manson             Secretary              Senior Vice President,     2 World Trade Center               USA
                                                   Lehman Brothers Inc.       New York, NY 10048


Thomas E. Gengler, Jr.      Assistant Treasurer    Managing Director,         3 World Financial Center           USA
                                                   Lehman Brothers Inc.       New York, NY 10285


Joseph L. Ternullo          Assistant Treasurer    Tax Manager, The Boston    3 World Financial Center           USA
                                                   Company Advisors Limited   New York, NY 10285
                                                   Partnerships
                                                   Administration


Eileen M. Bannon            Assistant Secretary    Assistant Secretary,       2 World Trade Center               USA
                                                   Lehman Brothers Inc.       New York, NY 10048


Madeline Shapiro            Assistant Secretary    Assistant Secretary,       2 World Trade Center               USA
                                                   Lehman Brothers Inc.       New York, NY 10048
</TABLE>



<PAGE>


                             HBLP Acquisition Corp.
<TABLE>
<CAPTION>
     Name                    Office                 Occupation                    Address                  Citizenship
<S>                                <C>                      <C>                     <C>                          <C>    
Ron Hiram                   President              Managing Director,         3 World Financial Center           USA
                                                   Lehman Brothers Inc.       New York, NY 10285


Rocco Andriola              Vice President         Senior Vice President,     3 World Financial Center           USA
                                                   Lehman Brothers Inc.       New York, NY 10285


Thomas E. Gengler, Jr.      Assistant Treasurer    Managing Director,         3 World Financial Center           USA
                                                   Lehman Brothers Inc.       New York, NY 10285


Alfred Grotell              Assistant Treasurer    Managing Director,         3 World Financial Center           USA
                                                   Lehman Brothers Inc.       New York, NY 10285


Eileen M. Bannon            Assistant Secretary    Assistant Secretary,       2 World Trade Center               USA
                                                   Lehman Brothers Inc.       New York, NY 10048

</TABLE>


<PAGE>


CONTROL PERSONS:

LEHMAN BROTHERS HOLDINGS INC.

Directors:

           Roger S. Berlind
           USA
           Berlind Productions
           10 East 53rd Street
           30th Floor
           New York, New York 10028
           Private Investor

           John J. Byrne
           USA
           Fund America Enterprises
           The 1820 House
           Main Street
           Norwich, Vermont 05055-0850
           Chairman of Fund America Enterprises

           Richard S. Fuld, Jr.
           USA
           Lehman Brothers Inc.
           3 World Financial Center
           New York, New York 10285
           Chairman and Chief Executive Officer of Lehman Brothers Inc.

           Katsumi Funaki
           Japan
           Nippon Life Insurance Company
           2-2, Yuraka-cho 1 Chome
           Chiyoda-ku 100 Tokyo Japan
           Senior General Manager for International Business of the
           Finance and Investment Business Office of the Nippon
           Life Insurance Company

           John D. Macomber
           USA
           JDM Investment Group
           2806 N. Street, N.W.
           Washington, D C 20007
           Private Investor

<PAGE>

           Dina Merrill
           Theo Teryazos
           NY Office-RKO Pavilion
           551 Madison Avenue
           14th Floor
           New York, New York 10022
           Actress and Private Investor

           T. Christopher Pettit
           USA
           Lehman Brothers Inc.
           3 World Financial Center
           10th Floor
           New York, New York 10285
           President and Chief Operating Officer of Lehman Brothers

           Masataka Shimasaki
           Japan
           Nippon Life Insurance Company
           1251 Avenue of the Americas
           52nd Floor
           New York, New York 10020

           Malcolm Wilson
           USA
           Kent, Hazzard, Jaeger, Greer, Wilson & Fay
           50 Main Street
           White Plains, New York 10606-1920
           Counsel to Kent, Hazzard, Jaeger, Greer, Wilson & Fay

Executive Officers who are not Directors:

           Ronald Gallatin
           USA
           Senior Executive Vice President
           Lehman Brothers Inc.
           3 World Financial Center
           10th Floor
           New York, New York 10285

           David Marcus
           USA
           Managing Director and General Counsel
           Lehman Brothers Inc.
           3 World Financial Center
           19th Floor
           New York, New York 10285

<PAGE>

           Robert Matza
           USA
           Managing Director and Chief Financial Officer
           Lehman Brothers Inc.
           3 World Financial Center
           6th Floor
           New York, New York 10285

           Michael Milversted
           USA
           Managing Director and Treasurer
           Lehman Brothers Inc.
           388 Greenwich Street
           8th Floor
           New York, New York 10013




<PAGE>


                                 Lb I Group Inc.

<TABLE>
<CAPTION>

    Name                    Office                 Occupation                    Address                 Citizenship
<S>                                <C>                      <C>                     <C>                    <C>    
Paul L. Abbott              Chairman of the        Managing Director,         3 World Financial Center     USA
                            Board, President and   Lehman Brothers Inc.       New York, NY 10285
                            Chief Executive
                            Officer


Thomas E. Gengler, Jr.      Senior Vice President  Managing Director,         3 World Financial Center     USA
                                                   Lehman Brothers Inc.       New York, NY 10285


Stephen J. Bier             Vice President         Managing Director,         3 World Financial Center     USA
                                                   Lehman Brothers Inc.       New York, NY 10285


Ron Hiram                   Vice President         Managing Director,         3 World Financial Center     USA
                                                   Lehman Brothers Inc.       New York, NY 10285


Donald Petrow               Vice President         Managing Director,         3 World Financial Center     USA
                                                   Lehman Brothers Inc.       New York, NY 10285


Michael R.. Milversted      Treasurer, Senior      Managing Director,         3 World Financial Center     USA
                            Vice President         Lehman Brothers Inc.       New York, NY 10285


Karen C. Manson             Secretary              Senior Vice President,     2 World Trade Center         USA
                                                   Lehman Brothers Inc.       New York, NY 10048


Eileen M. Bannon            Assistant Secretary    Assistant Secretary,       2 World Trade Center         USA
                                                   Lehman Brothers Inc.       New York, NY 10048


Madeline Shapiro            Assistant Secretary    Assistant Secretary,       2 World Trade Center         USA
                                                   Lehman Brothers Inc.       New York, NY 10048



<PAGE>


                                   APPENDIX B

On May 16, 1988, E.F. Hutton & Co., Inc.  ("Hutton"),  a company acquired by and
merged into Lehman Brothers, pleaded guilty to a Federal Information involving a
failure to file currency  transaction reports with the Internal Revenue Service.
The  criminal  disposition  involved  three  felony  counts  and  resulted  in a
$1,010,000  fine.  The majority of the  activities on which the  Information  is
based took place  during 1982 and 1983,  and none  occurred  later than  August,
1984.  All alleged  failures to file took place in  Hutton's  Providence,  Rhode
Island branch office.

Lehman Brothers has been involved in a number of civil proceedings which concern
matters arising in connection with the conduct of its business.  Certain of such
proceedings  have  resulted  in  findings  of a  violation  of  federal or state
securities  laws.  Each of these  proceedings  was  settled  by Lehman  Brothers
consenting to the entry of an order without admitting or denying the allegations
in the  complaint.  All of such  proceedings  are  reported  and  summarized  in
Schedule D to Lehman  Brothers'  Form BD filed with the  Securities and Exchange
Commission, which descriptions are hereby incorporated by reference.




<PAGE>


                                   APPENDIX C

                        Beneficial Ownership of Shares of
                     Common Stock, par value $.01 per share,
                          of Houston Biotechnology Inc.


                                                                                                 Percentage of Common
        Name                                     Amount                   D/I                    Stock
<S>                                               <C>                    <C>                     <C>                        
Lehman Brothers Inc.                              1,750                   D                     .06%
                                                  1,808 (W)


Ophthalmic Research Services I Inc.               19,883                  D                     .66%
                                                  20,546 (W)


Ophthalmic Research Services II Inc.              1,808                   D                     .06%
                                                  1,868 (W)


HLBP Acquisition Corp.                            476,900                 D                    15.75%
                                                  492,797 (W)


LB I Group Inc.                                   21,691                  I                     .72%
                                                  22,414 (W)


Lehman Brothers Holdings Inc.                     500,341                 I                    16.53%
                                                  517,019 (W)

- ----------------------------------------------------------
(D) - Direct ownership and indirect ownership of shares held by subsidiaries.
(I) - Indirect ownership of shares held by LB.
(W)- Warrants
</TABLE>

<PAGE>
                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549


                                  SCHEDULE 13D

                    Under the Securities Exchange Act of 1934
                                (Amendment No. 1)

                       HOUSTON BIOTECHNOLOGY INCORPORATED

                                (Name of Issuer)

                     Common Stock, par value $.01 per share

                         (Title of Class of Securities)

                                  441840105000

                                 (CUSIP Number)

                                    Secretary
                              Lehman Brothers Inc.
                         2 World Trade Center, 15th Flr.
                            New York, New York 10048
                                 (212) 528-5772



                  (Name, Address and Telephone Number of Person
                Authorized to Receive Notice and Communications)

                                  July 30, 1993


             (Date of Event which Required Filing of This Statement)

If the filing person has previously  filed a statement on Schedule 13D to report
the  acquisition  which is the subject of this  Schedule 13D, and is filing this
schedule because of Rule 13d-1(b)(3) or (4), check the following box [ ].

Check the following box if a fee is being paid with the statement [ ]. (A fee is
not required only if the reporting  person (1) has a previous  statement on file
reporting  beneficial  ownership  of more  than  five  percent  of the  class of
securities  described  in Item 1;  and (2) has  filed  no  amendment  subsequent
thereto reporting  beneficial  ownership of five percent or less of such class.)
(See Rule 13d-7).

NOTE:      Six copies of this statement, including all exhibits, should be filed
           with the Commission. See Rule 13d-1(a) for other parties to whom 
           copies are to be sent.


<PAGE>


SCHEDULE 13D

CUSIP NO. 441840105000

1.     Name of Reporting Person
       S.S. or I.R.S. No. of Above Person

       Lehman Brothers Inc.

2.     Check the Appropriate Box if a Member of a Group (see instructions)

       (a) [ ]
       (b) [ ]

3.     SEC Use Only

4.     Source of Funds (see instructions)

       0

5.     Check Box if Disclosure of Legal Proceedings is Required Pursuant Items
       2(d) or 2(E)

       [X]

6.     Citizenship or Place of Organization

       Delaware

7.     Number of Shares Beneficially Owned by Each Reporting Person with Sole
       Voting Power

       24,228

8.     Number of Shares Beneficially Owned by Each Reporting Person with Shared
       Voting Power

       0

9.     Number of Shares Beneficially Owned by Each Reporting Person with Sole
       Dispositive Power

       24,228

10.    Number of Shares Beneficially Owned by Each Reporting Person with Shared
       Dispositive Power

       0

11.    Aggregate Amount Beneficially Owned by Each Reporting Person

       24,228

12.    Check Box if the Aggregate Amount in Row (11) Excludes Certain Shares
       (see instructions)

       [    ]

13.    Percent of Class Represented by Amount in Row (11)

       0.63%

14.    Type of Reporting Person (see instructions)

       BD, CO


<PAGE>


SCHEDULE 13D

CUSIP NO. 441840105000

1.     Name of Reporting Person
       S.S. or I.R.S. No. of Above Person

       Hutton Ophthalmic Research Services 1 Inc.

2.     Check the Appropriate Box if a Member of a Group (see instructions)

       (a) [    ]
       (b) [    ]

3.     SEC Use Only

4.     Source of Funds (see instructions)

       0

5.     Check Box if Disclosure of Legal Proceedings is Required Pursuant to
       Items 2(d) or 2(E)

       [     ]

6.     Citizenship or Place of Organization

       Delaware

7.     Number of Shares Beneficially Owned by Each Reporting Person with Sole
       Voting Power

       20,546

8.     Number of Shares Beneficially Owned by Each Reporting Person with Shared
       Voting Power

       0

9.     Number of Shares Beneficially Owned by Each Reporting Person with Sole
       Dispositive Power

       20,546

10.    Number of Shares Beneficially Owned by Each Reporting Person with Shared
       Dispositive Power

       0

11.    Aggregate Amount Beneficially Owned by Each Reporting Person

       20,546

12.    Check Box if the Aggregate Amount in Row (11) Excludes Certain Shares
       (see instructions)

       [     ]

13.    Percent of Class Represented by Amount in Row (11)

       0.53%

14.    Type of Reporting Person (see instructions)

       CO


<PAGE>


SCHEDULE 13D

CUSIP NO. 441840105000

1.     Name of Reporting Person
       S.S. or I.R.S. No. of Above Person

       Hutton Ophthalmic Research Services 2 Inc.

2.     Check the Appropriate Box if a Member of a Group (see instructions)

       (a) [ ]
       (b) [ ]

3.     SEC Use Only

4.     Source of Funds (see instructions)

       0

5.     Check Box if Disclosure of Legal Proceedings is Required Pursuant to 
       Items 2(d) or 2(E)

       [    ]

6.     Citizenship or Place of Organization

       Delaware

7.     Number of Shares Beneficially Owned by Each Reporting Person with Sole 
       Voting Power

       1868

8.     Number of Shares Beneficially Owned by Each Reporting Person with Shared
       Voting Power

       0

9.     Number of Shares Beneficially Owned by Each Reporting Person with Sole
       Dispositive Power

       1868

10.    Number of Shares Beneficially Owned by Each Reporting Person with Shared
       Dispositive Power

11.    Aggregate Amount Beneficially Owned bv Each Reporting Person

       1868

12.    Check Box if the Aggregate Amount in Row (11) Excludes Certain Shares
       (see instructions)

       [    ]

13.    Percent of Class Represented by Amount in Row (11)

       0.05%

14.    Type of Reporting Person (see instructions)

       CO


<PAGE>


SCHEDULE 13D

CUSIP NO. 441840105000

1.     Name of Reporting Person
       S.S. or I.R.S. No. of Above Person

       Shearson/HBLP Acquisition Corp.

2.     Check the Appropriate Box if a Member of a Group (see instructions)

       (a) [ ]
       (b) [ ]

3.     SEC Use Only

4.     Source of Funds (see instructions)

       0

5.     Check Box if Disclosure of Legal Proceedings is Required Pursuant to
       Items 2(d) or 2(E)

       [    ]

6.     Citizenship or Place of Organization

       Delaware

7.     Number of Shares Beneficially Owned by Each Reporting Person with Sole
       Voting Power

       492,797

8.     Number of Shares Beneficially Owned by Each Reporting Person with Shared
       Voting Power

       0

9.     Number of Shares Beneficially Owned by Each Reporting Person with Sole
       Dispositive Power

       492,797

10.    Number of Shares Beneficially Owned by Each Reporting Person with Shared
       Dispositive Power

       0

11.    Aggregate Amount Beneficially Owned by Each Reporting Person

       492,797

12.    Check Box if the Aggregate Amount in Row (11) Excludes Certain Shares
       (see instructions)

       [     ]

13.    Percent of Class Represented by Amount in Row (11)

       12.72%

14.    Type of Reporting Person (see instructions)

       CO


<PAGE>


Item 1.    Security and Issuer.

The class of equity  securities  to which this  statement  relates is the Common
Stock, par value $.01 per share (the "Common Stock"),  of Houston  Biotechnology
Incorporated,  a  Delaware  corporation  (the  "Company").  The  address  of the
principal  executive  offices of the Company is 3608 Research Forest Drive,  The
Woodlands, Texas 77381.

Item 2.    Identity and Background.

This  statement is filed on behalf of the  following  entities  (the  "Reporting
Persons"):

           Lehman Brothers Inc. ("LB"), a Delaware corporation
           World Financial Center
           200 Vesey Street
           New York, N.Y.
           LB is a full-line securities firm.

           Hutton Ophthalmic Research Services 1 Inc. ("HORS 1"), a Delaware
           corporation
           World Financial Center
           200 Vesey Street
           New York, N.Y.
           The sole business of HORS 1 is to hold the stock of the Company

           Hutton Ophthalmic Research Services 2 Inc. ("HORS 2"), a Delaware
           corporation
           World Financial Center
           200 Vesey Street
           New York, N.Y.
           The sole business of HORS 2 is to hold the stock of the Company

           Shearson/HBLP Acquisition Corp. ("Acquisition Corp")
           World Financial Center
           200 Vesey Street
           New York, N.Y.
           The sole business of Acquisition Corp is to hold the stock of the
           Company

The  following  entities  are control  persons  (the  "Control  Persons") of the
Reporting Persons:

           E.F. Hutton Group Inc., a Delaware corporation ("EFH")
           World Financial Center
           200 Vesey Street
           New York, N.Y.
           EFH is a holding company and the parent of HORS I and HORS II

           Lehman Brothers Group Inc., a Delaware corporation ("Group")
           World Financial Center
           200 Vesey Street
           New York, N.Y.
           Group is a holding company.  It is the parent of Acquisition Corp.

<PAGE>


           Lehman Brothers Holdings Inc., a Delaware corporation ("Holdings")
           World Financial Center
           200 Vesey Street
           New York, N.Y.
           Holdings through its domestic and foreign  subsidiaries is a fullline
           securities firm. It is the immediate parent of LB.

           American Express Company ("AMEXCO"), a New York corporation
           World Financial Center
           200 Vesey Street New York, N.Y.
           AMEXCO and its subsidiaries  are principally  engaged in the business
           of providing travel related services, investors diversified financial
           services,  international  banking services,  information services and
           investment services. AMEXCO is the immediate parent of Holdings.

The names,  residence or business addresses,  citizenships and present principal
occupations  or  employment  of the  executive  officers  and  directors  of the
Reporting Persons and the Control Persons are set forth in Appendix A hereto.

Except as stated in Appendix B hereto, none of the Reporting Persons, or, to the
best  knowledge  of the  Reporting  Persons,  the Control  Persons or any of the
persons  listed in  Appendix  A hereto  has  during the last five years (i) been
convicted in a criminal  proceeding  (excluding  traffic  violations  or similar
misdemeanors)  or (ii)  been a party  to a civil  proceeding  of a  judicial  or
administrative body of competent jurisdiction and as a result of such proceeding
was or is  subject  to a  judgment,  decree  or  final  order  enjoining  future
violations of, or mandating  activities  subject to, federal or state securities
laws or finding any violation with respect to such laws.

Item 3.    Source of Funds or Other Consideration.

The Reporting  Persons  acquired  479,341 shares  ("Shares") of Common Stock and
Warrants  ("Warrants") to purchase 16,678 shares ("Warrant Shares") Common Stock
as a liquidating  distribution from Houston Biotech Partners,  L.P. ("LP").  The
Reporting  Persons  understand  that they acquired a right to receive the Shares
and Warrants as of July 30, 1993.  The Shares and Warrants were  distributed  to
the  Reporting  Persons  during August 1993.  No  consideration  was paid by the
Reporting Persons to acquire the Shares or the Warrants.

HORS 1 and HORS 2 had acquired an aggregate of 21,000  shares of Common Stock in
l992.

Item 4.    Purpose of the Transaction.

The Reporting Persons hold all of the shares of Common Stock and Warrants of the
Company for investment  purposes.  Depending on their  evaluation of a number of
factors,  including the Company's business,  prospects and financial  condition,
the market for the Company's securities, other available opportunities,  general
economic conditions, money and stock market conditions and regulatory approvals,
the Reporting  Persons may decide to dispose of all or a portion of such shares,
Warrants and/or Warrant Shares in accordance with applicable laws.

<PAGE>


Item 5.    Interest in Securities of the Issuer.

            (a) The  aggregate  beneficial  ownership  of  Common  Stock  of the
                Reporting  Persons  and,  to  their  knowledge,  of the  Control
                Persons and persons  listed in Appendix A hereto is set forth in
                Appendix C hereto.

            (b) Each  Reporting  Person  and each  person  listed in  Appendix A
                hereto  has the power to vote and  dispose  of all of the Common
                Stock beneficially owned by such person as set forth in Appendix
                C hereto. AMEXCO may be deemed to beneficially own the shares of
                Common Stock beneficially owned by the Reporting Persons. AMEXCO
                disclaims such beneficial ownership.

            (c) Except as described herein, there were no purchases and sales of
                Common Stock  effected  during the past 60 days by the Reporting
                Persons  or, to their  knowledge,  the  Control  Persons  or any
                person listed in Appendix A hereto.

            (d) Neither  the  Reporting  Persons  nor, to their  knowledge,  the
                Control  Persons  or any of the  persons  listed in  Appendix  A
                hereto knows of any other person who has the right to receive or
                the  power to direct  the  receipt  of  dividends  from,  or the
                proceeds   from  the  sale  of,  any  shares  of  Common   Stock
                beneficially owned by the Reporting Persons.

            (e) Not Applicable.

Item 6.    Contracts, Arrangements, Understandings or Relationships with Respect
           to Securities of the Issuer.

None

Item 7.    Material to be Filed as Exhibits.

Exhibit 1 - Joint Filing  Agreement  dated  September 15, 1993 among and between
LB, HORS 1, HORS 2 and Acquisition Corp.


<PAGE>


                                   SIGNATURES

After  reasonable  inquiry and to the best of my knowledge and belief, I certify
that the information set forth in this statement is true, complete and correct.

Dated: September 15, 1993

                              LEHMAN BROTHERS INC.

                              By:
                                           Name:  Karen C. Manson
                                           Title:  Senior Vice President

                              HUTTON OPHTHALMIC RESEARCH SERVICES 1 INC.

                              By:
                                           Name:  Karen C. Manson
                                           Title:  Secretary

                              HUTTON OPHTHALMIC RESEARCH SERVICES 2 INC.

                              By:
                                           Name:  Karen C. Manson
                                           Title:  Secretary

                              SHEARSON/HBLP ACQUISITION CORP.

                              By:
                                           Name:  Eileen M. Bannon
                                           Title:  Assistant Secretary

<PAGE>


                                   APPENDIX A

DIRECTORS AND EXECUTIVE OFFICERS OF REPORTING PERSONS AND CONTROL PERSON

See following pages





<PAGE>



                              Lehman Brothers Inc.

                               Board of Directors
<TABLE>
<CAPTION>

       Name                             Business Address                       Principal Occupation                    Citizenship
  <S>                                        <C>                                     <C>                                     <C>
Roger S. Berlind                      Berlind Productions                      Private Investor                               USA
                                      10 East 53rd Street
                                      30th Floor
                                      New York, NY 10022
- -------------------------------------
Philip Caldwell                       Lehman Brothers Inc.                     Senior Managing Director                       USA
                                      3 World Financial Center                 of Lehman Brothers
                                      19th Floor
                                      New York, NY 10285
- -------------------------------------
Richard S. Fuld, Jr.                  Lehman Brothers Inc.                     President and Chief Operating Officer of       USA
                                      3 World Financial Center                 Lehman Brothers  
                                      10th Floor
                                      New York, NY 10285
- -------------------------------------
Harvey Golub                          American Express Company                 President, Chairman and Chief Exec             USA
                                      American Express Tower                   Officer of the American Express Company
                                      World Financial Center
                                      51st Floor
                                      New York, NY 10285
- -------------------------------------
John R. Laird                         Lehman Brothers Inc.                     Director                                       USA
                                      3 World Financial Center
                                      19th Floor
                                      New York, NY 10285
- -------------------------------------
Sherman R. Lewis, Jr.                 Lehman Brothers Inc.                     Vice Chairman of Lehman Brothers               USA
                                      3 World Financial Center
                                      16th Floor
                                      New York, NY 10285
</TABLE>


<PAGE>


                              Lehman Brothers Inc.
                    Executive Officers Who Are Not Directors

<TABLE>
<CAPTION>

     Name                    Business Address                                  Principal Occupation                     Citizenship
   <S>                          <C>                                             <C>                                             <C>
David Marcus               Lehman Brothers Inc.                         Managing Director of Lehman Brothers                   USA
                           3 World Financial Center
                           19th Floor
                           New York, NY 10285

Richard B. Stewart, Jr.    Lehman Brothers Inc.                         Vice Chairman of Lehman Brothers                       USA
                           3 World Financial Center
                           19th Floor
                           New York, NY 10285

Malcolm Wilson             Kent, Hazzard, Jaeger, Greer,Wilson & Fay    Counsel to Kent,                                       USA
                           50 Main Street                               Hazzard, Jaeger, Greer,
                           White Plains, NY 10606-1920                  Wilson & Fay


Ronald L. Gallatin         Lehman Brothers Inc.                         Senior Executive Vice President of Lehman Brothers     USA
                           3 World Financial Center
                           10th Floor
                           New York, NY 10028

Robert Matza               Lehman Brothers Inc.                         Managing Director and Principal Financial Officer of   USA
                           3 World Financial Center                     Lehman Brothers
                           6th Floor
                           New York, NY 10285

Michael Milversted         Shearson Lehman Brothers Inc.                Managing Director and Treasurer of Lehman Brothers     USA
                           American Express Tower
                           World Financial Center
                           12th Floor
                           New York NY 10285

T. Christopher Pettit      Lehman Brothers Inc.                         Managing Partner of Lehman Brothers                    USA
                           3 World Financial Center
                           10th Floor
                           New York, NY 10028

</TABLE>


<PAGE>




                   Hutton Ophthalmic Research Services 1 Inc.
                        Directors And Executive Officers


Name, Title And Address           Principal Occupation             Citizenship
Ron Hiram                         Managing Director,                     USA
Director                          Lehman Brothers Inc.
President & CFO
388 Greenwich Street
28th Floor
New York, NY 10013

Craig Emrick                      Senior Vice President,                 USA
Treasurer                         Lehman Brothers Inc.
American Express Tower
3 World Financial Center
12th Floor
New York, NY 10285

Karen C. Manson                   Senior Vice President,                 USA
Secretary                         Lehman Brothers, Inc.
2 World Trade Center
15th Floor
New York, NY 10048

Kenneth Braddock                  Managing Director,                     USA
Assistant Treasurer               Lehman Brothers Inc.
American Express Tower
3 World Financial Center
16th Floor
New York, NY 10013

Thomas E. Gengler, Jr.            Managing Director,                     USA
Assistant Treasurer               Lehman Brothers Inc.
388 Greenwich Street
31st Floor
New York, NY 10013

Joseph L. Ternullo                Tax Manager, The Boston                USA
Assistant Treasurer               Company Advisors Limited
One Boston Place                  Partnerships Administration
Boston, MA 02108

                                                                         USA
Eileen M. Bannon                  Assistant Secretary,
Assistant Secretary               Lehman Brothers Inc.
2 World Trade Center
15th Floor
New York, NY 10048

                                                                         USA
Madeline L. Shapiro               Assistant Secretary,
Assistant Secretary               Lehman Brothers Inc.
2 World Trade Center
15th Floor
New York, NY 10048


<PAGE>


                   Hutton Ophthalmic Research Services 2 Inc.
                        Directors And Executive Officers


Name, Title And Address         Principal Occupation                Citizenship

Ron Hiram                        Managing Director,                       USA
Director                         Lehman Brothers Inc.
President & CFO
388 Greenwich Street
28th Floor
New York, NY 10013


Craig Emrick                     Senior Vice President,                   USA
Treasurer                        Lehman Brothers Inc.
American Express Tower
3 World Financial Center
12th Floor
New York, NY 10285


Karen C. Manson                  Senior Vice President,                   USA
Secretary                        Lehman Brothers, Inc.
2 World Trade Center
15th Floor
New York, NY 10048


Kenneth Braddock                 Managing Director,                       USA
Assistant Treasurer              Lehman Brothers Inc.
American Express Tower
3 World Financial Center
16th Floor
New York, NY 10013


Thomas E. Gengler, Jr.           Managing Director,                       USA
Assistant Treasurer              Lehman Brothers Inc.
388 Greenwich Street
31st Floor
New York, NY 10013


Joseph L. Ternullo               Tax Manager, The Boston                  USA
Assistant Treasurer              Company Advisors Limited
One Boston Place                 Partnerships Administration


Eileen M. Bannon                 Assistant Secretary,                     USA
Assistant Secretary              Lehman Brothers Inc.
2 World Trade Center
15th Floor
New York, NY 10048


Madeline L. Shapiro              Assistant Secretary,                     USA
Assistant Secretary              Lehman Brothers Inc.
2 World Trade Center
15th Floor
New York, NY 10048


<PAGE>


                         Shearson/HBLP Acquisition Corp.
                        Directors And Executive Officers

<TABLE>
<CAPTION>
Name, Title And Address                   Principal Occupation                        Citizenship
     <S>                                          <C>                                        <C>
Rocco Andriola                           Senior Vice President                              USA
Shearson Lehman Brothers Plaza           of Shearson Lehman Brothers Inc.
388 Greenwich Street
New York, NY 10013


Eliot Fried*                             Managing Director                                  USA
American Express Tower                   of Shearson Lehman Brothers Inc.
World Financial Center
New York, NY 10285


Ron Hiram                                Executive Vice President                           USA
Shearson Lehman Brothers Plaza           of Shearson Lehman Brothers Inc.
388 Greenwich Street
New York, NY 10013


Robert Matza*                            Managing Director                                  USA
American Express Tower                   of Shearson Lehman Brothers Inc.
World Financial Center
New York, NY 10285

- ----------------------------------------------------
*    Director of Shearson/HBLP Acquisition Corp.
</TABLE>


<PAGE>


                           The E. F. Hutton Group Inc.
                        Directors And Executive Officers


Name, Title And Address          Principal Occupation           Citizenship

Richard B. Stewart, Jr.          Chief Financial Officer,       USA
Director                         Lehman Brothers Inc.
American Express Tower
3 World Financial Center
New York, NY 10285


Kenneth Braddock                 Managing Director,             USA
Vice President                   Lehman Brothers Inc.
American Express Tower
3 World Financial Center
16th Floor
New York. NY 10285


Thomas E. Gengler, Jr.           Managing Director,             USA
Vice President                   Lehman Brothers Inc.
388 Greenwich Street
31st Floor
New York, NY 10013


Maxine L. Gerson                 Senior Vice President,         USA
Vice President                   Lehman Brothers Inc.
2 World Trade Center
15th Floor
New York, NY 10048


Alfred Grotell                   Managing Director,             USA
Vice President                   Lehman Brothers Inc.
388 Greenwich Street
31st Floor
New York, NY 10013


Thomas E. Hommel                 Senior Vice President,         USA
Vice President                   Lehman Brothers Inc.
388 Greenwich Street
35th Floor
New York, NY 10013


Karen M. Muller                  Managing Director,             USA
Vice President                   Lehman Brothers Inc.
2 World Trade Center
15th Floor
New York, NY 10048


Joseph Polizzoto                 Managing Director              USA
Vice President                   Lehman Brothers Inc.
388 Greenwich Street
35th Floor
New York, NY 10013

<PAGE>
Name, Title And Address         Principal Occupation           Citizenship

Michael R. Milverstad           Managing Director,             USA
Treasurer                       Lehman Brothers Inc.
American Express Tower
3 World Financial Center
12th floor
New York, NY 10285


Karen C. Manson                 Senior Vice President,         USA
Secretary                       Lehman Brothers, Inc.
2 World Trade Center
15th Floor
New York, NY 10048


Thomas J. Burns                 Executive Vice President,      USA
President                       Lehman Brothers Inc.
388 Greenwich Street
33rd Floor
New York, NY 10013


Craig Emrick                    Senior Vice President,         USA
Assistant Treasurer             Lehman Brothers Inc.
American Express Tower
3 World Financial Center
12th Floor
New York, NY 10013


Eileen M. Bannon                Assistant Secretary,          USA
Assistant Secretary             Lehman Brothers Inc.
2 World Trade Center
15th Floor
New York, NY 10048


Madeline L. Shapiro             Assistant Secretary,          USA
Assistant Secretary             Lehman Brothers Inc.
2 World Trade Center
15th Floor
New York, NY 10048


John D. Smith, Jr.              Assistant Secretary,          USA
Assistant Secretary             Lehman Brothers Inc.
2 World Trade Center
15th Floor
New York, NY 10048



<PAGE>




                           Lehman Brothers Group Inc.

                               Board Of Directors

<TABLE>
<CAPTION>

  Name                               Business Address                      Principal Occupation                        Citizenship
   <S>                                    <C>                                       <C>                                   <C>
Eliot Fried                           Lehman Brothers Inc.             Managing Director of Lehman Brothers Inc.        USA
                                      3 World Financial Center         ("Lehman Brothers")
                                      18th Floor
                                      New York, NY 10285


Richard Stewart, Jr.                  Lehman Brothers Inc.             Vice Chairman of Lehman Brothers                 USA
                                      3 World Financial Center
                                      19th Floor
                                      New York, NY 10285


</TABLE>


<PAGE>


                           Lehman Brothers Group Inc.
                    Executive Officers Who Are Not Directors

<TABLE>
<CAPTION>

Name                          Business Address                      Principal Occupation                            Citizenship
  <S>                           <C>                                        <C>                                                 <C>
Michael Milversted            Lehman Brothers Inc.                  Managing Director and Treasurer of Lehman Brothers        USA
                              388 Greenwich Street
                              8th Floor
                              New York, NY 10013


Yutaka Hashimoto              Nippon Life Insurance Company         Managing Director of Nippon Life                         Japan
                              2-2, Yuraku-cho 1 Chome
                              Chiyoda-ku Tokyo 100 Japan


Sherman R. Lewis, Jr.         Lehman Brothers Inc.                  Vice Chairman of Lehman Brothers                          USA
                              3 World Financial Center
                              16th Floor
                              New York, NY 10285


Dina Merrill                  RKO Pavillion                         Actress and Private Investor                              USA
                              551 Madison Avenue
                              14th Floor
                              New York, NY 10022


Roger S. Penske               Penske Corporation                    President of the Penske Corporation                       USA
                              13400 Outer Drive West
                              Detroit, Michigan 48239


Malcolm Wilson                Kent, Hazzard, Jaeger, Greer,         Counsel to Kent, Jaeger, Greer, Wilson and Fay            USA
                              Wilson & Fay
                              50 Main Street
                              White Plains, NY 10606-1920

</TABLE>

<PAGE>


                          Lehman Brothers Holdings Inc.
                               Board Of Directors

<TABLE>
<CAPTION>

 Name                        Business Address                         Principal Occupation                            Citizenship
   <S>                             <C>                                     <C>                                                <C>
Roger S. Berlind               Berlind Productions                 Private Investor                                           USA
                               10 East 53rd Street
                               30th Floor
                               New York, NY 10022


David M. Culver                CAI Capital Corporation             Chairman of CAI Capital Corporation                      Canada
                               3429 Brummond Street
                               Suite 200
                               Montreal, Quebec H3G 1X6


Richard S. Fuld, Jr.           Lehman Brothers Inc.                President and Chief Operating Officer of Lehman            USA
                               3 World Fiancial Center             Brothers Inc.
                               10th Floor
                               New York, NY 10285


Katsumi Funaki                 Nippon Life Insurance Company       General Manager for North America, Nippon Life            Japan
                               780 Third Avenue                    Insurance Company
                               43rd Floor
                               New York, NY 10017
- -

Richard M. Furlaud             Bristol-Myers Squibb Company        Former President of Bristol-Myers Squibb Company           USA
                               150 E. 52nd street
                               12th Floor
                               New York, New York 10022


Harvey Golub                   American Express Company            Chairman, President and Chief Executive Officer of the     USA
                               American Express Tower              American Express Company
                               World Financial center
                               51st Floor
                               New York, New York 10285


Yutaka Hashimoto               Nippon Life Insurance Company       Managing Director of Nippon Life                          Japan
                               2-2, Yuraku-cho 1 Chome
                               Chiyoda-ku Tokyo 100 Japan

</TABLE>

<PAGE>


                          Lehman Brothers Holdings Inc.
                               Board of Directors
<TABLE>
<CAPTION>

 Name                   Business Address                       Principal Occupation                                     Citizenship
    <S>                       <C>                                     <C>                                                      <C>
Sherman R. Lewis, Jr.     Lehman Brothers Inc.              Vice Chairman of Lehman Brothers                                  USA
                          3 World Financial Center
                          16th Floor
                          New York, NY 10285


Dina Merrill              RKO Pavillion                     Actress and Private Investor                                      USA
                          551 Madison Avenue
                          14th Floor
                          New York, NY 10022


Roger S. Penske           Penske Corporation                President of the Penske Corporation                               USA
                          13400 Outer Drive West
                          Detroit, Michigan 48239


Malcolm Wilson            Kent, Hazzard, Jaeger, Greer,     Counsel to Kent, Jaeger, Greer, Wilson and Fay                    USA
                          Wilson & Fay
                          50 Main Street
                          White Plains, NY 10606-1920


</TABLE>


<PAGE>


                          Lehman Brothers Holdings Inc.
                    Executive Officers Who Are Not Directors

<TABLE>
<CAPTION>

 Name                      Business Address                       Principal Occupation                                   Citizenship
  <S>                         <C>                                     <C>                                                      <C>
Ronald L. Gallatin           Lehman Brothers Inc.              Senior Executive Vice President of Lehman Brothers             USA
                             3 World Financial Center
                             10th Floor
                             New York, NY 10285


David Marcus                 Lehman Brothers Inc.              Managing Director and General Counsel                          USA
                             3 World Financial Center          of Lehman Brothers
                             19th Floor
                             New York, NY 10285


Robert Matza                 Lehman Brothers Inc.              Managing Director and Chief Financial Officer                  USA
                             3 World Financial Center          of Lehman Brothers
                             6th Floor
                             New York, NY 10285


Michael Milversted           Lehman Brothers Inc.              Managing Director and Treasurer of Lehman Brothers             USA
                             388 Greenwich Street
                             8th Floor
                             New York, NY 10013


T. Christopher Pettit        Lehman Brothers Inc.              Managing Partner of Lehman Brothers                            USA
                             3 World Financial Center
                             10th Floor
                             New York, NY 10285

</TABLE>



<PAGE>


                            American Express Company
                               Board of Directors

<TABLE>
<CAPTION>

  Name                      Business Address                       Principal Occupation                                  Citizenship
  <S>                         <C>                                     <C>                                                       <C>
Anne L. Armstrong            Kleberg Bank Building             Chairman of the Board of Trustees, Center for Strategic          USA
                             Sixth & Kleberg Streets           and International Studies
                             Kingsville, TX 78363


William G. Bowen             140 East 62nd Street              President, the Andrew Mellon Foundation                          USA
                             New York, NY 10021


John J. Byrne, Jr.           The 1820 House                    Chairman & CEO, Fund American Companies                          USA
                             Main Street
                             Norwich, VT 05055


David M. Culver              CAI Capital Corporation           Chairman of CAI Capital Corporation                            Canada
                             3429 Brummond Street
                             Suite 200
                             Montreal, Quebec H3G 1X6


Charles W. Duncan, Jr.       600 Travis                        Duncan Interests                                                 USA
                             61st Floor
                             Houston, TX 77002-3007


George M.C. Fisher           1303 East Algonquin Road          Chairman and CEO, Motorola, Inc.                                 USA
                             Schaumburg, IL 60196


Richard M. Furlaud           Bristol-Myers Squibb Company      Former President of Bristol-Myers Squibb Company                 USA
                             150 E. 52nd street
                             12th Floor
                             New York, New York 10022


Harvey Golub                 American Express Company          Chairman, President and Chief Executive Officer of the           USA
                             American Express Tower            American Express Company
                             World Financial Center
                             51st Floor
                             New York, New York 10285


Beverly Hills Greenough      211 Central Park West             Former President, New York City Opera                            USA
                             New York, NY 10024
</TABLE>

<PAGE>


                            American Express Company
                               Board of Directors

<TABLE>
<CAPTION>

 Name                     Business Address                            Principal Occupation                              Citizenship
   <S>                         <C>                                        <C>                                                <C>
F. Ross Johnson             200 Galleria Parkway, N.W.             Chairman & CEO, RJM Group                                USA
                            Suite 970
                            Atlanta, GA 30339


Vernon E. Jordan, Jr.       1333 New Hampshire Ave., N.W.          Partner, Akin, Gump, Hauer & Feld                        USA
                            Suite 400
                            Washington, D. C. 20036


Henry A. Kissinger          350 Park Ave.                          Chairman, Kissinger Associates, Inc.                     USA
                            26th Floor
                            New York, NY 10022


Drew Lewis                  Martin Tower                           Chairman & CEO, Union Pacific Corporation                USA
                            Eighth & Eaton Avenues
                            16th Floor
                            Bethlehem, PA 18018


Aldo Papone                 American Express Company               Senior Advisor, American Express Company                 USA
                            American Express Tower
                            3 World Financial Center
                            New York, NY 10285


Roger S. Penske             Penske Corporation                     President of the Penske Corporation                      USA
                            13400 Outer Drive West
                            Detroit, Michigan 48239


Frank P. Popoff             2030 Willard H. Dow Center             President & CEO, The Dow Chemical Company                USA
                            Midland, MI 48674


Jeffrey E. Stiefler         IDS Tower 10                           President & CEO, IDS Financial Corporation               USA
                            Minneapolis, MN 5440

</TABLE>

<PAGE>


                            American Express Company
                             American Express Tower
                            3 World Financial Center
                               New York, NY 10285

                    Executive Officers Who Are Not Directors

<TABLE>
<CAPTION>

  Name                            Office                                                           Citizenship
  <S>                               <C>                                                                <C>
Mark J. Babij                   Assistant Comptroller                                                  USA


Gary A. Beller                  Executive Vice President                                               USA


Pamela A. Davis                 Vice President and Assistant Treasurer                                 USA


Daniel T. Henry                 Senior Vice President and Comptroller                                  USA


Joseph W. Keilty                Executive Vice President                                               USA


Donald J. Ledger                Assistant Secretary                                                    USA


Jonathan S. Linen               Vice Chairman                                                          USA


Michael P. Monaco               Executive Vice President, Chief Financial Officer & Treasurer          USA


Barbara A. Neysmith             Assistant Secretary                                                    USA


Stephen P. Norman               Secretary                                                              USA


Louise M. Parent                Executive Vice President and General Counsel                           USA


John J. Perrell III             Assistant Comptroller                                                  USA


Robert M. Pyle, Jr.             Senior Assistant Secretary                                             USA


Irene C. Roberts                Senior Vice President                                                  USA


Vincent J. Santo                Assistant Comptroller                                                  USA


Thomas Schick                   Executive Vice President                                               USA


Ronald C. Stovall               Vice President and Assistant Treasurer                                 USA
</TABLE>


<PAGE>


                                   APPENDIX B

On May 16, 1988, E.F. Hutton & Co., Inc.  ("Hutton"),  a company acquired by and
merged into LB, pleaded guilty to a Federal  Information  involving a failure to
file  currency  transaction  reports  with the  Internal  Revenue  Service.  The
criminal  disposition  involved three felony counts and resulted in a $1,010,000
fine.  The majority of the  activities  on which the  Information  is based took
place  during 1982 and 1983,  and none  occurred  later than August,  1984.  All
alleged failures to file took place in Hutton's Providence,  Rhode Island branch
office.

LB has been  involved in a number of civil  proceedings  which  concern  matters
arising  in  connection  with  the  conduct  of its  business.  Certain  of such
proceedings  have  resulted  in  findings  of a  violation  of  federal or state
securities  laws. Each of these  proceedings was settled by LB consenting to the
entry of an order without admitting or denying the allegations in the complaint.
All of such  proceedings  are reported and summarized in Schedule D to LB's Form
BD filed with the Securities and Exchange  Commission,  which  descriptions  are
hereby incorporated by reference.



<PAGE>


                                   APPENDIX C

                        Beneficial Ownership of Shares of
                     Common Stock, par value $.01 per share,
                      of Houston Biotechnology Incorporated


<TABLE>
<CAPTION>
                                                                                           Percentage of Common
  Name                                          Amount                   D/I                    Stock
    <S>                                          <C>                     <C>                    <C>
Lehman Brothers Inc.                              1,750                   (D)
                                                  58 (W)                  (D)
                                                  21,697                  (I)
                                                     723 (W)              (I)                    .63%


Houston Ophthalmic Research Services 1 Inc.       19,883                  (D)
                                                     663 (W)              (D)                    .53%


Houston Ophthalmic Research Services 2 Inc.       1,808                   (D)
                                                     60 (W)               (D)                    .05%


Shearson/HLBP Acquisition Corp.                   476,900                 (D)
                                                   15,897 (W)             (D)                   12.72%


E.F. Hutton Group Inc.                            21,697                  (I)
                                                     723 (W)              (I)                    .58%


Lehman Brothers Group Inc.                        476,900                 (I)
                                                   15,897 (W)             (I)                   12.72%


Lehman Brothers Holdings Inc.                     500,341                 (I)
                                                  16,678 (W)              (I)                   13.35%

- ----------------------------------------------------------
(D) - Direct ownership and indirect ownership of shares held by subsidiaries.
(I) - Indirect ownership of shares held by LB.
(W) - Warrants

</TABLE>

<PAGE>


                             Joint Filing Agreement

In accordance  with Rule 13d-1(f) under the Securities  Exchange Act of 1934, as
amended, the persons named below agree to joint filing on behalf of each of them
of a Statement on Schedule 13D (including  amendments thereto) and further agree
that this  Joint  Filing  Agreement  be  included  as an  Exhibit  to such joint
filings.  In evidence thereof,  the undersigned,  being duly authorized,  hereby
execute this Agreement this 15th day of September, 1993.

                               LEHMAN BROTHERS INC.

                                    By:
                                                 Name:  Karen C. Manson
                                                 Title:  Senior Vice President

                                    HUTTON OPHTHALMIC RESEARCH SERVICES 1 INC.

                                    By:
                                                 Name:  Karen C. Manson
                                                 Title:  Secretary

                                    HUTTON OPHTHALMIC RESEARCH SERVICES 2 INC.

                                    By:
                                                 Name:  Karen C. Manson
                                                 Title:  Secretary

                                    SHEARSON/HBLP ACQUISITION  CORP.

                                    By:
                                                 Name:  Eileen M. Bannon
                                                 Title:  Assistant Secretary


<PAGE>

                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13D

                    Under the Securities Exchange Act of 1934
                                       ( )

                       HOUSTON BIOTECHNOLOGY INCORPORATED
                                (Name of Issuer)

                     Common Stock, par value $.01 per share

                         (Title of Class of Securities)

                                  167763101000

                                 (CUSIP Number)

                                    Secretary
                              Lehman Brothers Inc.
                         2 World Trade Center, 15th Flr.
                            New York, New York 10048
                                 (212) 528-5772

                     (Name, Address and Telephone Number of
                     Person Authorized to Receive Notice and
                                 Communications)

                                  July 30, 1993

             (Date of Event which Required Filing of This Statement)

If the filing person has previously  filed a statement on Schedule 13D to report
the  acquisition  which is the subject of this  Schedule 13D, and is filing this
schedule because of Rule 13d-l(b)(3) or (4), check the following box [ ].

Check the following box if a fee is being paid with the statement [X]. (A fee is
not required only if the reporting  person (1) has a previous  statement on file
reporting  beneficial  ownership  of more  than  five  percent  of the  class of
securities  described  in Item 1;  and (2) has  filed  no  amendment  subsequent
thereto reporting  beneficial  ownership of five percent or less of such class.)
(See Rule 13d-7).

NOTE:  Six copies of this statement, including all exhibits, should be filed 
       with the Commission. See Rule 13d-l(a) for other parties to whom copies
       are to be sent.



<PAGE>


SCHEDULE 13D
CUSIP NO. 167763101000

1.     Name of Reporting Person
       S.S. or I.R.S. No. of Above Person

       Lehman Brothers Inc.

2.     Check the Appropriate Box if a Member of a group (see instructions)

       (a)  [  ]
       (b)  [  ]

3.     SEC Use Only

4.     Source of Funds (see instructions)

       0

5.     Check Box if Disclosure of Legal Proceedings is Required Pursuant to 
       Items 2(d) or 2(E)

       [X]

6.     Citizenship or Place of Organization

       Delaware

7.     Number of Shares Beneficially Owned by Each Reporting Person with Sole
       Voting Power

       24,228

8.     Number of Shares Beneficially Owned by Each Reporting Person with Shared
       Voting Power

       0

9.     Number of Shares Beneficially Owned by Each Reporting Person with Sole
       Dispositive Power

       24,228

10.    Number of Shares Beneficially Owned by Each Reporting Person with Shared
       Dispositive Power

       0

11.    Aggregate Amount Beneficially Owned by Each Reporting Person

       24,228

12.    Check Box if the Aggregate Amount in Row (11) Excludes Certain Shares
       (see instructions)

       [   ]

13.    Percent of Class represented by Amount in Row (11)

       0.63%

14.    Type of Reporting Person (see instructions)

       BD, CO

SCHEDULE 13D
CUSIP NO. 167763101000

1.     Name of Reporting Person
       S.S. or I.R.S. No. of Above Person

       Hutton Ophthalmic Research Services 1 Inc.

2.     Check the Appropriate Box if a Member of a Group (see instructions)

       (a)        [      ]
       (b)        [      ]

3.     SEC Use Only

4.     Source of Funds (see instructions)

       0

5.     Check Box if Disclosure of Legal Proceedings Is Required Pursuant to 
       Items 2(d) or 2(E)

       [ ]

6.     Citizenship or Place of Organization

       Delaware

7.     Number of Shares Beneficially Owned by Each Reporting Person with Sole
       Voting Power

       20,552

8.     Number of Shares Beneficially Owned by Each Reporting Person with Shared 
       Voting Power

       0

9.     Number of Shares Beneficially Owned by Each Reporting Person with Sole
       Dispositive Power

       20,552

10.    Number of Shares Beneficially Owned by Each Reporting Person with Shared
       Dispositive Power

       0

11.    Aggregate Amount Beneficially Owned by Each Reporting Person

       20,552

12.    Check Box if the Aggregate Amount in Row (11) Excludes Certain Shares
       (see instructions)

       [    ]

13.    Percent of Class Represented by Amount in Row (11)

       0.53%

14.    Type of Reporting Person (see instructions)

       CO


<PAGE>


SCHEDULE 13D

CUSIP NO. 167763101000

1.     Name of Reporting Person
       S.S. or I.R.S. No. of Above Person

       Hutton Ophthalmic Research Services 2 Inc.

2.     Check the Appropriate Box if a Member of a Group (see instructions)

       (a) [ ]
       (b) [ ]

3.     SEC Use Only

4.     Source of Funds (see instructions)

       0

5.     Check Box if Disclosure of Legal Proceedings Is Required Pursuant to 
       Items 2(d) or 2(E)

       [    ]

6.     Citizenship or Place of Organization

       Delaware

7.     Number of Shares Beneficially Owned by Each Reporting Person with Sole 

       Voting Power

       1868

8.     Number of Shares Beneficially Owned by Each Reporting Person with Shared
       Voting Power

       0

9.     Number of Shares Beneficially Owned by Each Reporting Person with Sole
       Dispositive Power

       1868

10.    Number of Shares Beneficially Owned by Each Reporting Person with Shared
       Dispositive Power

       0

11.    Aggregate Amount Beneficially Owned by Each Reporting Person

       1868

12.    Check Box if the Aggregate Amount in Row (11) Excludes Certain Shares
       (see instructions)

       [     ]

13.    Percent of Class Represented by Amount in Row (11)

       0.05%

14.    Type of Reporting Person (see instructions)

       CO


SCHEDULE 13D

CUSIP NO. 167763101000

1.       Name of Reporting Person
         S.S. or I.R.S. No. of Above Person

         Shearson/HBLP Acquisition Corp.

2.       Check the Appropriate Box if a Member of a Group (see instructions)

                  (a)      [   ]
                  (b)      [   ]

3.       SEC Use Only

4.       Source of Funds (see instructions)

         0

5.       Check Box if Disclosure of Legal Proceedings Is Required Pursuant to 
         Items 2(d) or 2(E)

         [   ]

6.       Citizenship or Place of Organization

         Delaware

7.       Number of Shares Beneficially Owned by Each Reporting Person with Sole
         Voting Power

         492,797

8.       Number of Shares Beneficially Owned by Each Reporting Person with 
         Shared Voting Power

         0

9.       Number of Shares Beneficially Owned by Each Reporting Person with Sole
         Dispositive Power

         492,797

10.      Number of Shares Beneficially Owned by Each Reporting Person with 
         Shared Dispositive Power

         0

11.      Aggregate Amount Beneficially Owned by Each Reporting Person

         492,797

12.      Check Box if the Aggregate Amount in Row (11) Excludes Certain Shares 
         (see instructions)

         [   ]

13.      Percent of Class Represented by Amount in Row (11)

         12.77%

14.      Type of Reporting Person (see instructions)

         CO

<PAGE>


Item 1.    Security and Issuer.

The class of equity  securities  to which this  statement  relates is the Common
Stock, par value $.01 per share (the "Common Stock"),  of Houston  Biotechnology
Incorporated,  a  Delaware  corporation  (the  "Company").  The  address  of the
principal  executive  offices of the Company is 3608 Research Forest Drive,  The
Woodlands, Texas 77381.


Item 2.    Identity and Background.

This  statement is filed on behalf of the  following  entities  (the  "Reporting
Persons"):

           Lehman Brothers Inc. ("LB"), a Delaware corporation
           World Financial Center
           200 Vesey Street
           New York, NY
           LB is a full-line securities firm.

           Hutton Ophthalmic Research Services 1 Inc. ("HORS 1"), a Delaware 
           corporation
           World Financial Center
           200 Vesey Street
           New York, NY
           The sole business of HORS 1 is to hold the stock of the Company

           Hutton Ophthalmic Research Services 2 Inc. ("HORS 2"), a Delaware 
           corporation
           World Financial Center
           200 Vesey Street
           New York, NY
           The sole business of HORS 2 is to hold the stock of the Company

           Shearson/HBLP Acquisition Corp. ("Acquisition Corp")
           World Financial Center
           200 Vesey Street
           New York, NY
           The sole business of Acquisition Corp is to hold the stock of the 
           Company

The  following  entities  are control  persons  (the  "Control  Persons") of the
Reporting Persons:

           E.F. Hutton Group Inc., a Delaware corporation ("EFH")
           World Financial Center
           200 Vesey Street
           New York, NY
           EFH is a holding company and the parent of HORS I and HORS II

            Lehman Brothers Group Inc., a Delaware corporation ("Group")
            World Financial Center
            200 Vesey Street
            New York, NY
           Group is a holding company. It is the parent of Acquisition Corp.

           Lehman Brothers Holdings Inc., a Delaware corporation ("Holdings")
           World Financial Center
           200 Vesey Street
           New York, NY
           Holdings through its domestic and foreign subsidiaries is a full-line
           securities firm. It is the immediate parent of LB.

           American Express Company ("AMEXCO"), a New York corporation
           World Financial Center
           200 Vesey Street
           New York, NY
           AMEXCO and its subsidiaries  are principally  engaged in the business
           of providing travel related services, investors diversified financial
           services,  international  banking services,  information services and
           investment services. AMEXCO is the immediate parent of Holdings.

The names,  residence or business addresses,  citizenships and present principal
occupations  or  employment  of the  executive  officers  and  directors  of the
Reporting Persons and the Control Persons are set forth in Appendix A hereto.

Except as stated in Appendix B hereto, none of the Reporting Persons, or, to the
best  knowledge  of the  Reporting  Persons,  the Control  Persons or any of the
persons  listed in Appendix A has during the last five years (i) been  convicted
in a criminal proceeding  (excluding traffic violations or similar misdemeanors)
or (ii) been a party to a civil proceeding of a judicial or administrative  body
of competent  jurisdiction  and as a result of such proceeding was or is subject
to a  judgment,  decree  or final  order  enjoining  future  violations  of,  or
mandating activities subject to, federal or state securities laws or finding any
violation with respect to such laws.


Item 3.    Source of Funds or Other Consideration.

The Reporting  Persons  acquired  479,341 shares  ("Shares") of Common Stock and
Warrants  ("Warrants") to purchase 16,678 shares ("Warrant Shares") Common Stock
as liquidating  distribution  from Houston Biotech  Partners,  L.P. ("LP").  The
Reporting  Persons  understand  that they acquired a right to receive the Shares
and Warrants as of July 30, 1993.  No  consideration  was paid by the  Reporting
Persons to acquire the Shares or the Warrants.

HORS 1 and HORS 2 had acquired and aggregate of 21,000 shares of Common Stock in
1992.


<PAGE>


Item 4.    Purpose of the Transaction.

The Reporting persons hold all of the shares of Common Stock and Warrants of the
Company for investment  purposes.  Depending on their  evaluation of a number of
factors,  including the Company's business,  prospects and financial  condition,
the market for the Company's securities, other available opportunities,  general
economic conditions, money and stock market conditions and regulatory approvals,
the Reporting  Persons may decide to dispose of all or a portion of such shares,
Warrants and/or Warrant Shares in accordance with applicable laws.

Item 5.    Interest in Securities of the Issuer.

           (a)    The  aggregate  beneficial  ownership  of Common  Stock of the
                  Reporting  Persons  and,  to their  knowledge,  of the Control
                  Persons and  persons  listed in Appendix A hereto is set forth
                  in Appendix C hereto.

           (b)    Each  Reporting  Person and each  person  listed in Appendix A
                  hereto has the power to vote and  dispose of all of the Common
                  Stock  beneficially  owned  by such  person  as set  forth  in
                  Appendix C hereto.  AMEXCO may be deemed to  beneficially  own
                  the shares of Common Stock beneficially owned by the Reporting
                  Persons. AMEXCO disclaims such beneficial ownership.

           (c)    Except as described herein,  there were no purchases and sales
                  of  Common  Stock  effected  during  the  past  60 days by the
                  Reporting Persons or, to their knowledge,  the Control Persons
                  or any person listed in Appendix A hereto.

           (d)    Neither the  Reporting  Persons nor, to their  knowledge,  the
                  Control  Persons or any of the  persons  listed in  Appendix A
                  hereto  knows of any other person who has the right to receive
                  or the power to direct the receipt of dividends  from,  or the
                  proceeds  from  the  sale  of,  any  shares  of  Common  Stock
                  beneficially owned by the Reporting Persons.

           (e)    Not Applicable.

Item 6.    Contracts, Arrangements, Understandings or Relationships with Respect
to Securities of the Issuer.

None

Item 7.    Material to be Filed as Exhibits.

Exhibit 1 - Joint Filing  Agreement  dated  September 15, 1993 among and between
LB, HORS 1, HORS 2 and Acquisition Corp.


<PAGE>


                                   SIGNATURES

After  reasonable  inquiry and to the best of my knowledge and belief, I certify
that the information set forth in this Statement is true, complete and correct.

Dated: September 15, 1993


                                       LEHMAN BROTHERS INC.

                                        BY:  ____________________________
                                                Name: Karen C. Manson
                                                Title: Senior Vice President


                                      HUTTON OPHTHALMIC RESEARCH SERVICES 1 INC.

                                        BY:  _____________________________
                                                  Name: Karen C. Manson
                                                  Title:  Secretary
     
     
                                      HUTTON OPHTHALMIC RESEARCH SERVICES 2 INC.

                                        BY:  _____________________________
                                                  Name: Karen C. Manson
                                                  Title:  Secretary


                                      SHEARSON/HBLP ACQUISITION CORP.

                                        BY:  _____________________________
                                                  Name: Eileen M. Bannon
                                                  Title: Assistant Secretary


<PAGE>


                                   APPENDIX A


DIRECTORS AND EXECUTIVE OFFICERS OF REPORTING PERSONS AND CONTROL PERSON

- - See following pages -


<PAGE>


                                   APPENDIX B


On May 16, 1988, E.F. Hutton & Co., Inc.  ("Hutton"),  a company acquired by and
merged into LB, pleaded guilty to a Federal  Information  involving a failure to
file  currency  transaction  reports  with the  Internal  Revenue  Service.  The
criminal  disposition  involved three felony counts and resulted in a $1,010,000
fine.  The majority of the  activities  on which the  Information  is based took
place  during 1982 and 1983,  and none  occurred  later than August,  1984.  All
alleged failures to file took place in Hutton's Providence.  Rhode Island branch
office.

LB has been  involved in a number of civil  proceedings  which  concern  matters
arising  in  connection  with  the  conduct  of its  business.  Certain  of such
proceedings  have  resulted  in  findings  of a  violation  of  federal or state
securities  laws. Each of these  proceedings was settled by LB consenting to the
entry of an order without admitting or denying the allegations in the complaint.
All of such  proceedings  are reported and summarized in Schedule D to LB'S Form
BD filed with the Securities and Exchange  Commission,  which  descriptions  are
hereby incorporated by reference.


<PAGE>


                                   APPENDIX C


                        Beneficial Ownership of Shares of
                        Common Stock, par value $.01 per
                  share. of Houston Biotechnology Incorporated

<TABLE>
<CAPTION>
                                                                                               Percentage of Common
                          Name                                   Amount              D/I               Stock
<S>                                                               <C>                 <C>            <C>
Lehman Brothers Inc.                                              1,750              (D)
                                                                     58 (W)          (D)
                                                                 21,697              (I)
                                                                    723 (W)          (I)                 .63%

Houston Ophthalmic Research Services l Inc.                      19,883              (D)
                                                                    663 (W)          (D)                 .53%

Houston Ophthalmic Research Services 2 Inc.                       1,808              (D)
                                                                     60 (W)          (D)                 .05%

Shearson/HLBP Acquisition Corp.                                 476,900              (D)
                                                                 15,897 (W)          (D)               12.72%

E. F. Hutton Group Inc.                                          21,697              (I)
                                                                    723 (W)          (I)                 .58%

Lehman Brothers Group Inc.                                      476,900              (I)
                                                                 15,897 (W)          (I)               12.72%

Lehman Brothers Holdings Inc.                                   500,341              (I)
                                                                 16,678 (W)          (I)               13.35%
</TABLE>

- ---------------------
(D) - Direct  ownership and indirect  ownership of shares held by  subsidiaries.
(I) - Indirect ownership of shares held by LB (W) - Warrants


<PAGE>


                                                        Exhibit 1

                             Joint Filing Agreement

In accordance  with Rule 13d-1(f) under the Securities  Exchange Act of 1934, as
amended, the persons named below agree to joint filing on behalf of each of them
of a Statement on Schedule 13D (including  amendments thereto) and further agree
that this  Joint  Filing  Agreement  be  included  as an  Exhibit  to such joint
filings.  In evidence thereof,  the undersigned,  being duly authorized,  hereby
execute this Agreement this 15th day of September, 1993.



                                     LEHMAN BROTHERS INC.

                                        BY:  ____________________________
                                                Name: Karen C. Manson
                                                Title: Senior Vice President


                                      HUTTON OPHTHALMIC RESEARCH SERVICES 1 INC.

                                        BY:  _____________________________
                                                  Name: Karen C. Manson
                                                  Title:  Secretary
     
     
                                      HUTTON OPHTHALMIC RESEARCH SERVICES 2 INC.

                                        BY:  _____________________________
                                                  Name: Karen C. Manson
                                                  Title:  Secretary


                                      SHEARSON/HBLP ACQUISITION CORP.

                                        BY:  _____________________________
                                                  Name: Eileen M. Bannon
                                                  Title: Assistant Secretary





<PAGE>


                                                  
                              Lehman Brothers Inc.
                               Board of Directors
<TABLE>
<CAPTION>

Name                       Business Address               Principal Occupation                                          Citizenship
<S>                           <C>                           <C>                                                          <C> 
Roger S. Berlind           Berlind Productions            Private Investor                                                 USA
                           10 East 53rd Street
                           30th Floor
                           New York, NY 10022

Philip Caldwell            Lehman Brothers Inc.           Senior Managing Director of Lehman Brothers                      USA
                           3 World Financial Center
                           19th Floor
                           New York, NY 10285

Richard S. Fuld, Jr.       Lehman Brothers Inc.           President and Chief Operating Officer of Lehman Brothers         USA
                           3 World Financial Center
                           10th Floor
                           New York, NY 10285

Harvey Golub               American Express Company       President, Chairman and Chief Executive Officer of the           USA
                           American Express Tower         American Express Company
                           World Financial Center
                           51st Floor
                           New York, NY 10285

John R. Laird              Lehman Brothers Inc.           Director                                                         USA
                           3 World Financial Center
                           19th Floor
                           New York, NY 10285
                                                          Vice Chairman of Lehman Brothers
Sherman R. Lewis, Jr.      Lehman Brothers Inc.                                                                            USA
                           3 World Financial Center
                           16th Floor
                           New York, NY 10285

</TABLE>

<PAGE>


                                                                      9/13/93
                              Lehman Brothers Inc.
                           Board of Directors (cont'd)
<TABLE>
<CAPTION>

Name                        Business Address                Principal Occupation                           Citizenship
<S>                            <C>                             <C>                                             <C>   
David Marcus                Lehman Brothers Inc.            Managing Director of Lehman Brothers            USA
                            3 World Financial Center
                            19th Floor
                            New York, NY 10285


Richard B. Stewart, Jr.     Lehman Brothers Inc.            Vice Chairman of Lehman Brothers                USA
                            3 World Financial Center
                            19th Floor
                            New York, NY 10285


Malcolm Wilson              Kent, Hazzard, Jaeger, Greer,   Counsel to Kent,                                USA
                            Wilson & Fay                    Hazzard, Jaeger, Greer,
                            50 Main Street                  Wilson & Fay
                            White Plains, NY 10606-1920
</TABLE>
<PAGE>


                              Lehman Brothers Inc.
                    Executive Officers Who Are Not Directors

<TABLE>
<CAPTION>

Name                    Business Address                         Principal Occupation                                   Citizenship
<S>                       <C>                              <C>                                                           <C>   

Ronald L. Gallatin        Lehman Brothers Inc.             Senior Executive Vice President of Lehman Brothers            USA
                          3 World Financial Center
                          10th Floor
                          New York, NY 10028


Robert Matza              Lehman Brothers Inc.             Managing Director and Principal Financial Officer of Lehman   USA
                          3 World Financial Center         Brothers
                          6th Floor
                          New York, NY 10285


Michael Milversted        Shearson Lehman Brothers Inc.    Managing Director and Treasurer of Lehman Brothers            USA
                          American Express Tower
                          World Financial Center
                          12th Floor
                          New York, NY 10285


T. Christopher Pettit     Lehman Brothers Inc.             Managing Partner of Lehman Brothers                           USA
                          3 World Financial Center
                          10th Floor
                          New York, NY 10028


</TABLE>

<PAGE>




                   Hutton Ophthalmic Research Services 1 Inc.
                        Directors and Executive Officers

<TABLE>
<CAPTION>

Name, Title and Address                       Principal Occupation                                 Citizenship

<S>                                           <C>                                                   <C>
Ron Hiram                                     Managing Director, Lehman Brothers Inc.                 USA
Director
President & CFO
388 Greenwich Street, 28th Floor
New York, NY 10013


Craig Emrick                                  Senior Vice President, Lehman Brothers Inc.             USA
Treasurer
American Express Tower
3 World Financial Center
12th Floor
New York, NY 10285


Karen C. Manson                               Senior Vice President, Lehman Brothers. Inc.            USA
Secretary
2 World Trade Center, 15th Floor
New York, NY 10048


Kenneth Braddock                              Managing Director,                                      USA
Assistant Treasurer                           Lehman Brothers, Inc.
American Express Tower
3 World Financial Center
16th Floor
New York, NY 10013


Thomas E. Gengler, Jr.                        Managing Director, Lehman Brothers Inc.                 USA
Assistant Treasurer
388 Greenwich Street, 31st Floor
New York, NY 10013


Joseph L. Ternullo                            Tax Manager, The Boston                                 USA
Assistant Treasurer                           Company Advisors Limited
One Boston Place                              Partnerships Administration
Boston, MA 02108


Eileen M. Bannon                              Assistant Secretary, Lehman Brothers Inc.               USA
Assistant Secretary
2 World Trade Center, 15th Floor
New York, NY 10048


Madeline L. Shapiro                           Assistant Secretary, Lehman Brothers Inc.               USA
Assistant Secretary
2 World Trade Center, 15th Floor
New York, NY 10048

</TABLE>

<PAGE>


                   Hutton Ophthalmic Research Services 2 Inc.
                        Directors and Executive Officers

<TABLE>
<CAPTION>
Name, Title and Address                      Principal Occupation                    Citizenship

<S>                                          <C>                                     <C>   
Ron Hiram                                     Managing Director, Lehman Brothers Inc.      USA
Director
President & CFO
388 Greenwich Street, 28th Floor
New York, NY 10013


Craig Emrick                                  Senior Vice President,                       USA
Treasurer                                     Lehman Brothers Inc.
American Express Tower
3 World Financial Center
12th Floor
New York, NY 10285


Karen C. Manson                               Senior Vice President,                       USA
Secretary                                     Lehman Brothers Inc.
2 World Trade Center, 15th Floor
New York, NY 10048


Kenneth Braddock                              Managing Director,                           USA
Assistant Treasurer                           Lehman Brothers, Inc.
American Express Tower
3 World Financial Center
16th Floor
New York, NY 10013

Thomas E. Gengler, Jr.                        Managing Director,                           USA
Assistant Treasurer                           Lehman Brothers Inc.
388 Greenwich Street, 31st Floor
New York, NY 10013

Joseph L. Ternullo                            Tax Manager, The Boston                      USA
Assistant Treasurer                           Company Advisors Limited
One Boston Place                              Partnerships Administration
Boston, MA 02108


Eileen M. Bannon                              Assistant Secretary, Lehman Brothers Inc.    USA
Assistant Secretary
2 World Trade Center, 15th Floor
New York, NY 10048


Madeline L. Shapiro                           Assistant Secretary, Lehman Brothers Inc.    USA
Assistant Secretary
2 World Trade Center, 15th Floor
New York, NY 10048

</TABLE>

<PAGE>


                         Shearson/HBLP Acquisition Corp.
                        Directors and Executive Officers
<TABLE>
<CAPTION>

Name, Title and Address            Principal Occupation                                   Citizenship
   <S>                                <C>                                                    <C>
Rocco Andriola                     Senior Vice President of  Shearson Lehman                USA
Shearson Lehman Brothers Plaza     Brothers Inc.
388 Greenwich Street
New York, NY 10013


Eliot Fried*                       Managing Director of Shearson Lehman                     USA
American Express Tower             Brothers Inc.
World Financial Center
New York, NY 10285


Ron Hiram                          Executive Vice President of Shearson Lehman              USA
Shearson Lehman Brothers Plaza     Brothers Inc.
388 Greenwich Street
New York, NY 10013


Robert Matza*                      Managing Director of Shearson Lehman                     USA
American Express Tower             Brothers Inc.
World Financial Center
New York, NY 10285


*Director of Shearson/HBLP Acquisition Corp.
</TABLE>


<PAGE>


                           The E. F. Hutton Group Inc.
                        Directors and Executive Officers
<TABLE>
<CAPTION>

Name, Title and Address                       Principal Occupation                    Citizenship
<S>                                            <C>                                    <C>   
                                                                                     
Richard B. Stewart, Jr.                       Chief Financial Officer,                    USA
Director                                      Lehman Brothers Inc.
American Express Tower
3 World Financial Center
New York, NY 10285

Kenneth Braddock                                                                          USA
Vice President                                Managing Director,
American Express Tower                        Lehman Brothers Inc.
3 World Financial Center,
16th Floor
New York, NY 10235

Thomas E. Gengler, Jr.                                                                    USA
Vice President                                Managing Director,
388 Greenwich Street, 31st Floor              Lehman Brothers Inc.
New York, NY 10013

Maxine L. Gerson                                                                          USA
Vice President                                Senior Vice President,
2 World Trade Center, 15th Floor              Lehman Brother Inc.
New York, NY 10048

Alfred Grotell Vice President                                                             USA
388 Greenwich Street, 31st Floor              Managing Director,
New York, NY 10013                            Lehman Brothers Inc.


Thomas E. Hommel                                                                          USA
Vice President                                Senior Vice President,
388 Greenwich Street, 35th Floor              Lehman Brothers Inc.
New York, NY 10013

Karen M. Muller                                                                           USA
Vice President                                Managing Director,
2 World Trade Center, 15th Floor              Lehman Brothers Inc.
New York, NY 10048
                                                                                          USA
Joseph Polizzoto                              Managing Director
Vice President                                Lehman Brothers Inc.
388 Greenwich Street, 35th Floor
New York, NY 10013

</TABLE>
<PAGE>


                           The E. F. Hutton Group Inc.
                        Directors and Executive Officers
<TABLE>
<CAPTION>

Name, Title and Address                         Principal Occupation                    Citizenship
<S>                                           <C>                                       <C>
                                                                                          USA
Michael R. Milverstad                         Managing Director,
Treasurer                                     Lehman Brothers Inc.
American Express Tower
3 World Financial Center
12th floor
New York, NY 10285

                                                                                           USA
Karen C. Manson                               Senior Vice President,
Secretary                                     Lehman Brothers, Inc.
2 World Trade Center
15th Floor
New York, NY 10048

                                                                                           USA
Thomas J. Burns                               Executive Vice President,
President                                     Lehman Brothers Inc.
388 Greenwich Street
33rd Floor
New York, NY 10013

                                                                                           USA
Craig Emrick                                  Senior Vice President,
Assistant Treasurer                           Lehman Brothers Inc.
American Express Tower
3 World Financial Center
12th Floor
New York, NY 10013

                                                                                           USA
Eileen M. Bannon                              Assistant Secretary,
Assistant Secretary                           Lehman Brothers Inc.
2 World Trade Center
15th Floor
New York, NY 10048

                                                                                           USA
Madeline L. Shapiro                           Assistant Secretary,
Assistant Secretary                           Lehman Brothers Inc.
2 World Trade Center
15th Floor
New York, NY 10048

                                                                                           USA
John D. Smith, Jr.                            Assistant Secretary,
Assistant Secretary                           Lehman Brothers Inc.
2 World Trade Center
15th Floor
New York, NY 10048

</TABLE>

<PAGE>



                           Lehman Brothers Group Inc.
                               Board of Directors

<TABLE>
<CAPTION>
Name                         Business Address                 Principal Occupation                 Citizenship
<S>                          <C>                              <C>                                   <C>  
Eliot Fried                  Lehman Brothers Inc.             Managing Director of                    USA
                             3 World Financial Center         Lehman Brothers Inc.
                             18th Floor                       ("Lehman Brothers")
                             New York, NY 10285

Richard Stewart, Jr.         Lehman Brothers Inc.             Vice Chairman of Lehman Brothers        USA
                             3 World Financial Center
                             19th Floor
                             New York, NY 10285

</TABLE>

                           Lehman Brothers Group Inc.
                    Executive Officers Who Are Not Directors

<TABLE>
<CAPTION>

Name                         Business Address            Principal Occupation                         Citizenship
<S>                          <C>                         <C>                                            <C> 
Michael Milversted           Lehman Brothers Inc.        Managing Director and Treasurer of Lehman      USA
                             388 Greenwich Street        Brothers
                             8th Floor
                             New York, NY 10013
</TABLE>

<PAGE>


                                                                09/13/93
                          Lehman Brothers Holdings Inc.
                               Board of Directors

<TABLE>
<CAPTION>
Name                      Business Address                          Principal Occupation                         Citizenship
<S>                       <C>                                        <C>                                         <C>
Roger S. Berlind          Berlind Productions                       Private Investor                              USA
                          10 East 53rd Street, 30th Floor
                          New York, NY  10022

David M. Culver           CAI Capital Corporation                   Chairman of CAI Capital Corporation          Canada
                          3429 Brummond Street
                          Suite 200
                          Montreal, Quebec H3G 1X6

Richard S. Fuld, Jr.      Lehman Brothers Inc.                      President and Chief Operating Officer of      USA
                          3 World Financial Center                  Lehman Brothers Inc.
                          10th Floor
                          New York, NY 10285

Katsumi Funaki            Nippon Life Insurance Company             General Manager for North America, Nippon    Japan
                          780 Third Avenue North                    Life Insurance Company
                          43rd Floor
                          New York, NY 10017

Richard M. Furlaud        Bristol-Myers Squibb Company              Former President of Bristol-Myers Squibb      USA
                          150 E. 52nd Street                        Company
                          12th Floor
                          New York, New York 10022

Harvey Golub              American Express Company                  Chairman, President and                       USA
                          American Express Tower                    Chief Executive Officer
                          World Financial Center                    of the American Express Company
                          51st Floor
                          New York, New York 10285

</TABLE>
<PAGE>


                          Lehman Brothers Holdings Inc.
                    Executive Officers Who Are Not Directors
<TABLE>
<CAPTION>
Name                            Business Address                 Principal Occupation                              Citizenship
<S>                             <C>                              <C>                                               <C>
Ronald L. Gallatin              Lehman Brothers Inc.             Senior Executive Vice President of Lehman          USA
                                3 World Financial Center         Brothers
                                10th Floor
                                New York, NY 10285

David Marcus                     Lehman Brothers Inc.            Managing Director and General Counsel of           USA
                                3 World Financial Center         Lehman Brothers
                                19th Floor
                                New York, NY 10285

Robert Matza                    Lehman Brothers Inc.             Managing Director and Chief Financial              USA
                                3 World Financial Center         Officer of Lehman Brothers
                                6th Floor
                                New York, NY 10285

Michael Milversted              Lehman Brothers Inc.             Managing Director and Treasurer of Lehman          USA
                                388 Greenwich Street             Brothers
                                8th Floor
                                New York, NY 10013

T. Christopher Pettit           Lehman Brothers Inc.             Managing Partner of Lehman Brothers                USA
                                3 World Financial Center
                                10th Floor
                                New York, NY 10285
</TABLE>
<PAGE>


                                                                       09/13/93
                            American Express Company
                               Board of Directors

<TABLE>
<CAPTION>
 Name                        Business Address                          Principal Occupation                         Citizenship
<S>                          <C>                                       <C>                                          <C>    
Anne L. Armstrong            Kleberg Bank Building                     Chairman of the Board                          USA
                             Sixth & Kleberg Streets                   of Trustees, Center for Strategic and
                             Kingsville, TX 78363                      International Studies

William G. Bowen             140 East 62nd Street                      President, the Andrew                          USA
                             New York, NY 10021                        Mellon Foundation


John J. Byrne, Jr.           The 1820 House                            Chairman & CEO, Fund                           USA
                             Main Street                               American Companies
                             Norwich, VT 05055

David M. Culver              CAI Capital Corporation                   Chairman of CAI Capital Corporation          Canada
                             3429 Brummond Street
                             Suite 200
                             Montreal, Quebec H3G lX6

Charles W. Duncan, Jr.       600 Travis                                Duncan Interests                               USA
                             61st Floor
                             Houston, TX 77002-3007

George M.C. Fisher           1303 East Algonquin Road                  Chairman and CEO, Motorola, Inc.               USA
                             Schaumburg, IL 60196

Richard M. Furlaud           Bristol-Myers Squibb Company              Former President of                            USA
                             150 E. 52nd Street                        Bristol-Myers Squibb Company
                             12th Floor
                             New York, New York 10022

</TABLE>
<PAGE>


                            American Express Company
                               Board of Directors

<TABLE>
<CAPTION>
Name                             Business Address                   Principal Occupation                         Citizenship
<S>                              <C>                                <C>                                          <C>  
Harvey Golub                     American Express Company           Chairman, President and                         USA
                                 American Express Tower             Chief Executive Officer
                                 World Financial Center             of the American Express
                                 51st Floor                         Company
                                 New York, New York 10285

Beverly Sills Greenough          211 Central Park West              Former President,                               USA
                                 New York, NY 10024                 New York City Opera


F. Ross Johnson                  200 Galleria Parkway, N.W.         Chairman & CEO,                                 USA
                                 Suite 970                          RJM Group
                                 Atlanta, GA 30339


Vernon E. Jordan, Jr.            1333 New Hampshire Ave., N.W.      Partner, Akin, Gump,                            USA
                                 Suite 400                          Hauer & Feld
                                 Washington, D.C. 20036


Henry A. Kissinger               350 Park Avenue                    Chairman, Kissinger Associates, Inc.            USA
                                 26th Floor
                                 New York, NY  10022

Drew Lewis                       Martin Tower                       Chairman & CEO,                                 USA
                                 Eighth & Eaton Avenues             Union Pacific Corporation
                                 16th Floor
                                 Bethlehem, PA  18018

Aldo Papone                      American Express Company           Senior Advisor,                                 USA
                                 American Express Tower             American Express Company
                                 3 World Financial Center
                                 New York, New York 10285
</TABLE>
<PAGE>


                            American Express Company
                               Board of Directors

<TABLE>
<CAPTION>
Name                 Business Address             Principal Occupation                         Citizenship
<S>                  <C>                          <C>                                          <C>     
Roger S. Penske      Penske Corporation           President of the Penske Corporation           USA
                     13400 Outer Drive West
                     Detroit, Michigan  48239

Frank P. Popoff      2030 Willard H. Dow Center   President & CEO,                              USA
                     Midland, MI  48674           The Dow Chemical Company

Jeffrey E. Stiefler  IDS Tower 10                 President & CEO,                              USA
                     Minneapolis, MN  5440        IDS Financial Corporation

</TABLE>
<PAGE>




                            American Express Company

                             American Express Tower
                            3 World Financial Center
                               New York, NY 10285

                    Executive Officers Who Are Not Directors

     Name                     Office                              Citizenship

Mark J. Babij       Assistant Comptroller                                USA


Gary A. Beller      Executive Vice President                             USA


Pamela A. Davis     Vice President and Assistant Treasurer               USA


Daniel T. Henry     Senior Vice President and Comptroller                USA


Joseph W. Keilty    Executive Vice President                             USA


Donald J. Ledger    Assistant Secretary                                  USA


Jonathan S. Linen   Vice Chairman                                        USA


Michael P. Monaco   Executive Vice President, Chief Financial Officer    USA
                    & Treasurer


Barbara A. Neysmith Assistant Secretary                                  USA


Stephen P. Norman   Secretary                                            USA


Louise M. Parent    Executive Vice President and General Counsel         USA


John J. Perrell III Assistant Comptroller                                USA


Robert M. Pyle, Jr. Senior Assistant Secretary                           USA


Irene C. Roberts    Senior Vice President                                USA


Vincent J. Santo    Assistant Comptroller                                USA


Thomas Schick       Executive Vice President                             USA


Ronald C. Stovall   Vice President and Assistant                         USA





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