MEDTOX SCIENTIFIC INC
10-K, 2000-03-28
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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                       SECURITIES AND EXCHANGE COMMISSION

                             Washington, D.C. 20549

                                    FORM 10-K

                [X] ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d)
              OF THE SECURITIES EXCHANGE ACT OF 1934 [FEE REQUIRED]
                   For the fiscal year ended December 31, 1999

          [ ] TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE

                SECURITIES EXCHANGE ACT OF 1934 [NO FEE REQUIRED]

                         Commission file number 1-11394

                             MEDTOX SCIENTIFIC, INC.

             (Exact name of Registrant as specified in its charter)

                Delaware                                 95-3863205
                --------                                ----------
       (State or other jurisdiction of                  (I.R.S. Employer
 incorporation or organization)                         Identification No.)

                402 West County Road D, St. Paul, Minnesota 55112

               (Address of principal executive offices) (Zip Code)

       Registrant's telephone number, including area code: (651) 636-7466

                    Securities registered pursuant to Section
                               12(b) of the Act:

                     Common Stock, par value $.15 per share
                                (Title of Class)

            Securities registered pursuant to Section 12(g) of the Act: None

Indicate by check mark whether the Registrant (1) has filed all reports required
to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during
the  preceding 12 months (or for such  shorter  period that the  Registrant  was
required  to file  such  reports),  and  (2) has  been  subject  to such  filing
requirements for the past 90 days. Yes X No __

Indicate by check mark if disclosure of delinquent  filers  pursuant to Item 405
of Regulation  S-K (229.405 of this chapter) is not contained  herein,  and will
not be contained,  to the best of registrant's knowledge, in definitive proxy or
information  statements  incorporated by reference in Part III of this Form 10-K
or any amendment to this Form 10-K. [X]

The  aggregate  market value of Common Stock of the  Registrant,  $.15 par value
("Common  Stock"),  held by  non-affiliates  of the Registrant is  approximately
$25,779,000  as of March 15,  2000,  based upon a price of $8.875 which price is
equal to the closing price for the Common Stock on the American Stock Exchange.

The number of shares of Common Stock outstanding as of March 15, 2000, was
2,904,659

Documents Incorporated by Reference:

                                                         Part of Form 10-K into
            Document                                     which incorporated

Portions of the Registrant's Proxy
Statement to be filed by April 10,2000..............................Part III

Such Proxy Statement,  except for portions thereof which have been  specifically
incorporated by reference, shall not be deemed "filed" as part of this report on
Form 10-K.

This document contains 86 pages and the Exhibit Index appears at page 33 hereof.
<PAGE>




                             MEDTOX SCIENTIFIC, INC.
                             FORM 10-K ANNUAL REPORT

                   FOR THE FISCAL YEAR ENDED DECEMBER 31, 1999

                                Table of Contents

ITEM NO.                                                                   PAGE

Part I

   1.    Business. . . . . . . . . . . . . . . . . . . . . . . . . .         4
   2.    Properties. . . . . . . . . . . . . . . . . . . . . . . . .        12
   3.    Legal Proceedings . . . . . . . . . . . . . . . . . . . . .        12
   4.    Submission of Matters to a Vote of
          Security Holders . . . . . . . . . . . . . . . . . . . . .        13

Part II

   5.    Market for the Registrant's Common Equity
          and Related Stockholder Matters. . . . . . . . . .                15
   6.    Selected Financial Data . . . . . . . . . . . . . . . . .          16
   7.    Management's Discussion and Analysis
          of Financial Condition and Results
          of Operations. . . . . . . . . . . . . . . . . . . . . . .        17
   8.    Financial Statements and Supplementary
          Data . . . . . . . . . . . . . . . . . . . . . . . . . . . .      26
   9.    Changes in and Disagreements With
          Accountants on Accounting

          and Financial Disclosure . . . . . . . . . . . . . . .            26

Part III

   10.   Directors and Executive Officers
          of the Registrant. . . . . . . . . . . . . . . . . . . . . .      27
   11.   Executive Compensation. . . . . . . . . . . . . . . .              27
   12.   Security Ownership of Certain Beneficial
          Owners and Management. . . . . . . . . . . . . .                  27
   13.   Certain Relationships and Related
          Transactions . . . . . . . . . . . . . . . . . . . . . . .        27

Part IV

   14.   Exhibits, Financial Statement Schedules
          and Reports on Form 8-K. . . . . . . . . . . . . .                28

Signatures. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .     34

<PAGE>


                                     PART I

               Cautionary Statement Identifying Important Factors
             That Could Cause the Company's Actual Results to Differ
               From Those Projected in Forward Looking Statements

         In  connection  with  the  "safe  harbor"  provisions  of  the  Private
Securities  Litigation  Reform  Act of 1995,  readers of this  document  and any
document  incorporated by reference  herein,  are advised that this document and
documents  incorporated by reference into this document  contain both statements
of historical facts and forward looking  statements.  Forward looking statements
are subject to certain risks and uncertainties, which could cause actual results
to differ  materially from those  indicated by the forward  looking  statements.
Examples  of forward  looking  statements  include,  but are not  limited to (i)
projections  of  revenues,  income or loss,  earning or loss per share,  capital
expenditures,  dividends,  capital  structure and other  financial  items,  (ii)
statements of the plans and objectives of the Company or its management or Board
of  Directors,  including  the  introduction  of new  products,  or estimates or
predictions  of actions  by  customers,  suppliers,  competitors  or  regulatory
authorities,   (iii)  statements  of  future  economic  performance,   and  (iv)
statements of assumptions  underlying  other statements and statements about the
Company or its business.

         This document and any documents  incorporated by reference  herein also
identify important factors which could cause actual results to differ materially
from  those  indicated  by the  forward  looking  statements.  These  risks  and
uncertainties include price competition, the decisions of customers, the actions
of  competitors,  the effects of government  regulation,  possible delays in the
introduction of new products,  customer acceptance of products and services, and
other  factors which are described  herein and/or in documents  incorporated  by
reference herein.

         The  cautionary  statements  made  pursuant to the  Private  Litigation
Securities  Reform Act of 1995 above and elsewhere by the Company  should not be
construed  as  exhaustive  or  as  any  admission   regarding  the  adequacy  of
disclosures made by the Company prior to the effective date of such Act. Forward
looking  statements are beyond the ability of the Company to control and in many
cases the Company  cannot  predict  what factors  would cause  results to differ
materially from those indicated by the forward looking statements.
<PAGE>

ITEM 1.  BUSINESS.
- -------  --------

         1.       General.

     MEDTOX Scientific,  Inc. (formerly EDITEK,  Inc.), a Delaware  corporation,
was  organized in  September,  1986 to succeed the  operations  of a predecessor
California  corporation.  MEDTOX Scientific,  Inc. and its subsidiaries,  MEDTOX
Laboratories,  Inc. and MEDTOX Diagnostics, Inc., are referred to herein as "the
Company".  MEDTOX Laboratories,  Inc. is a toxicology  laboratory which provides
forensic  toxicology,  clinical  toxicology,  and heavy metals analyses.  MEDTOX
Diagnostics,  Inc.  develops,  manufactures  and markets on-site  diagnostic and
screening  tests  which are used to detect  substances  in  humans,  foodstuffs,
animals, feed and the environment.  The Company is transitioning these operating
units into a broader service organization by coupling the underlying  laboratory
analysis and point-of-care  devices with logistics  management,  data management
and overall program management services.

                  The Company  entered the  laboratory  business on February 11,
1994 when it completed the acquisition of Princeton  Diagnostic  Laboratories of
America, Inc. ("PDLA"). On January 30, 1996, the Company acquired the assets and
certain  liabilities of the  predecessor  of MEDTOX  Laboratories,  Inc.  MEDTOX
Laboratories,  Inc. is now a wholly owned subsidiary.  For the fiscal year ended
December 31, 1999,  sales from  Laboratory  Services  accounted for 88.5% of the
Company's  revenues.  Revenue from the sale of the Company's on-site  diagnostic
and  screening  tests  and  other  products,  including  contract  manufacturing
services,  accounted for 11.5% of the total revenues of the Company for the year
ended December 31, 1999.

         2.       Principal Services, Products, and Markets.

     General. The Company has two reportable segments: "Laboratory Services" and
"Products  Sales."  Laboratory  Services include forensic  toxicology,  clinical
toxicology,  and heavy metal  analyses as well as logistics,  data,  and overall
program management services. Product Sales include sales of a variety of on-site
screening products and contract manufacturing.

         Laboratory Services

                   A. Employment Drug Testing Laboratory  Services.  The primary
source of  revenues  of the  Company  is the  provision  of  laboratory  testing
services for the  identification  of drugs of abuse.  These tests are  conducted
using methodologies such as various immunoassays, gas liquid chromatography, and
gas chromatography/mass  spectrometry.  MEDTOX Laboratories, Inc. was one of the
charter  laboratories  to be  certified  by the  federal  government  to perform
mandated drug testing on regulated employees. It pioneered security and chain of
custody  procedures,  including  sample  bar  coding  as well as  stereospecific
confirmation  methods that assist in maintaining  the integrity of the specimens
and the confidentiality of the test results.

                  The Company's  customers for substance  abuse testing  include
public and private corporations. In addition to public and private corporations,
substance  abuse  testing is also  conducted on behalf of service  firms such as
drug treatment  counseling  centers,  occupational  health clinics,  third party
administrators and hospitals.
<PAGE>

                  B.  Clinical  Toxicology.  The Company  has a fully  certified
clinical toxicology  reference  laboratory  specializing in esoteric therapeutic
drug  monitoring and emergency  toxicology.  The tests performed in the clinical
laboratory are conducted using methodologies such as various  immunoassays,  gas
liquid   chromatography,    high   performance   liquid   chromatography,    gas
chromatography/mass  spectrometry  and tandem  mass  spectrometry.  The  Company
performs  the  analyses  of  many   classes  of  drugs   including:   analgesic,
antianxiety,  anticholinergic,  anticoagulant,  anticonvulsant,  antidepressant,
antidiabetic,   antiemetic,  antihistamine,   antiinflammatory,   antimicrobial,
antipsychotic,   bronchodilator,    cardiovascular,   stimulant,   decongestant,
immunosuppressant,  local anesthetic,  muscle relaxant,  narcotic analgesic, and
sedative medications.

                  The  Company's  clients for this market  consist of hospitals,
clinics  and other  laboratories.  Laboratory  specimens  are  delivered  to the
Company  from  clients  across  the  country  by  the  Company's  own  couriers,
contracted delivery services and commercial overnight couriers.

     C. Heavy Metal, Trace Element, and Solvent Analyses. The Company operates a
laboratory in which blood and urine are tested for heavy metals, trace elements,
and solvents.  The tests are performed using the methodologies such as flame and
flameless atomic absorption,  inductively coupled plasma-mass spectrometry,  and
gas chromatography.

                  The Company's clients for this market are other  laboratories,
occupational  health  clinics  and  companies  which  need to test  patients  or
employees monitored for excess exposure to hazardous materials.

                  D.  Logistics,  Data,  and Program  Management  Services.  The
Company  also  provides  services  in the areas of  logistics  management,  data
management,  and  program  management.  These  services  support  the  Company's
underlying  business  of  laboratory  analysis  and  provide  added value to its
clients.  Value-added  services  include courier  services for medical  specimen
transportation,  management  programs for on-site drug testing,  data collection
and reporting  services,  coordination of specimen collection sites, and medical
surveillance program management.

         Product Sales

                  The Company's  on-site products are easy to use,  inexpensive,
point-of-care  tests. The tests are capable of rapidly detecting the presence of
a number of substances  in human urine or blood  samples,  foodstuffs,  animals,
feed and the  environment  without the  necessity  of  instruments  or technical
personnel.

                  In 1998,  the Company  received  FDA 510(k)  clearance  on the
first  of  its   second-generation   on-  site  test  products,   PROFILE(R)-II.
PROFILE(R)-II,  is  a  five-drug  lateral  flow  device  for  the  detection  of
drugs-of-abuse  in human urine. This  single-step,  immunoassay  device has been
combined with the Company's  data delivery  system and  laboratory  confirmation
capability to produce the  PROFILE(R)-II  Test System.  This integrated  on-site
testing  system is currently  being  marketed to  occupational  health  clinics,
corporate  clients,  third party  administrators,  and drug abuse counseling and
treatment centers.

                  In   addition   to   the    PROFILE(R)-II,    the    Company's
second-generation products also include VERDICT(R)-II on-site screening devices.
VERDICT(R)-II   products   are   manufactured   in  one,   two  and  three  drug
configurations.  Target markets  include  criminal  justice,  temporary  service
companies, the construction industry and drug rehabilitation facilities.
<PAGE>

                  The Company continues to market the EZ-SCREEN(R)  tests. These
tests are  qualitative  assays  utilized in  agricultural  diagnostics to detect
mycotoxins and antibiotic residues. Mycotoxins are hazardous substances produced
by fungal growth and frequently  contaminate corn, wheat, rye, barley,  peanuts,
tree  nuts,   cottonseed,   milk,  rice,  and  livestock  feeds.  The  EZ-SCREEN
agridiagnostic  tests are marketed to  regulatory  authorities  and producers of
foodstuffs and feeds.

                  The Company  distributes  on-site  tests for the  detection of
alcohol with the EZ-SCREEN(R)  Breath Alcohol Test. The test consists of a small
tube containing chemically treated crystals that change color in the presence of
alcohol.  The Company  purchases the Breath  Alcohol Test through a distribution
agreement.

                  3.       Marketing and Sales.

                  The  Company  believes  that the  combined  operations  of the
Laboratory  Services and the on-site test kits  manufactured by the Company have
created  synergy in the  marketing  of  comprehensive,  on-site  and  laboratory
testing  programs  to a common  customer  base.  The Company is in a position to
offer a full line of products and services for the  substance  abuse testing and
occupational medicine marketplace, including (1) on-site tests for the detection
of  substance  of  abuse  drugs  (2)  on-site   qualitative   and   quantitative
determination of alcohol intoxication (both disposable and electronic instrument
detection  devices);  (3) SAMHSA  certified  laboratory  testing  (screening and
confirmation);   (4)  biological   monitoring  of   occupational   toxins;   (5)
consultation; and (6) logistic, data management and program management services.

                  The  Company   currently   markets  these   products  and  all
laboratory services through its dedicated sales force, through independent third
party administrators and through occupational health clinics.

                  Major  Customers.  The  Company had no single  customer  whose
sales  amounted  to more than 10% of its total  revenues  during  the year ended
December 31, 1999. One  customer's  sales  amounted to  approximately  6% of the
revenues  of  MEDTOX  Laboratories,  Inc.  while  sales  to  the  United  States
government  and  its  agencies,   primarily  the  United  States  Department  of
Agriculture  ("USDA"),  amounted to  approximately  6% of the revenues of MEDTOX
Diagnostics, Inc.

                  4.       New Products, Research and Development.

                  Laboratory  Services.  The research and development  group for
Laboratory  Services  develops  new assays for new drug  entities,  develops new
assays for existing metabolites of drugs and other toxins, and improves existing
assays with the goal of improving the assays' robustness, sensitivity, accuracy,
precision,  specificity,  and cost.  Numerous new  laboratory-based  assays were
developed during 1999 using  immunochemistry,  liquid  chromatography  (LC), gas
chromatography (GC), gas chromatography with mass spectrometry  (GC/MS),  atomic
absorption (AA),  inductively  coupled plasma mass  spectrometry  (ICP/MS),  and
tandem mass  spectrometry  (LC/MS/MS).  The many new tests developed during 1999
expand the Company's  capabilities in the esoteric reference clinical toxicology
market  (providing  sophisticated  testing  for  hospitals  and other  reference
laboratories),  expand our  capabilities  and laboratory  services in biological
monitoring  of toxins in the  workplace,  expand our  capabilities  of detecting
drugs of abuse  for  clinical  and  workplace  analysis,  and  also  expand  our
capabilities  in  pharmaceutical  research  analysis.  During  1998,  Laboratory
Services  developed  a  medical  diagnostic  laboratory  to  service  multi-site
clinical  trials  for the  pharmaceutical  industry  and  also  provide  broader

<PAGE>

services  to  its  industrial  toxicology  and  occupational  medicine  clients.
Business generated by these expanded  laboratory  services to industrial clients
is already  becoming more  significant.  During 1999,  development  work for the
Company's new line of  nutritional  assays was  substantially  completed.  These
assays include analysis of vitamins,  amino acids,  trace elements,  measures of
oxidative stress, and activities of free radical scavenging  enzymes.  This work
allows Laboratory  Services to assess an individual's level of oxidative stress,
their ability to overcome that oxidative stress,  any nutritional  deficiencies,
and monitor  supplementation  to improve  their ability to overcome that stress.
This  area of  testing  is  being  shown to be  important  in the  detection  of
susceptibility to cancers,  cardiac diseases,  dementias,  macular degeneration,
and is related to the development of serious adverse effects of drugs.

                  Product Sales. Primary research and development efforts of the
Company  during 1999 focused on the  development  of tests to extend the Product
Sales offerings in the  single-step  PROFILE(R)-II  immunochromatographic  assay
product line  produced by the Company.  These  product line  extensions  include
VERDICT(R)-II   intended   primarily  for  the  criminal   justice   market  and
PROFILE(R)-ER intended for the emergency room market.

                  VERDICT(R)-II  consists of a line of simplified  Profile(R)-II
devices  designed  to test for the drugs  that the  criminal  justice  system is
primarily concerned with today. MEDTOX has found that its VERDICT(R)-II  product
has been well  received  in this  market and  increased  market  penetration  is
expected in fiscal 2000.  PROFILE(R)-ER  is an expanded  product which tests for
additional  drugs,  compared to  PROFILE(R)-II.  The added drugs are  especially
pertinent in the rule-out  diagnosis of suspected  toxic drugs in emergency room
settings.  The Company currently plans to introduce the PROFILE(R)-ER product in
fiscal 2000, following receipt of the appropriate FDA clearances.

         5.       Raw Materials.

                  Laboratory  Services.   The  raw  materials  required  by  the
laboratory  for urine drug  testing  consist  primarily  of two types:  specimen
collection  supplies  and  reagents  for  laboratory  analysis.  The  collection
supplies  include  Drug  Testing  Custody and Control  Forms that  identify  the
specimen and the client,  as well as document the  chain-of-custody.  Collection
supplies also consist of specimen bottles and shipping boxes.  Reagents for drug
testing are primarily  immunoassay screening products and various chemicals used
for  confirmation  testing.  The Company  believes  all of these  materials  are
available at competitive prices from other suppliers.

                  Product  Sales.  The primary raw  materials  required  for the
immunoassay-based  test kits  produced  by the  Company  consist of  antibodies,
antigens and other  reagents,  plastic  injection-molded  devices,  glass fiber,
nitrocellulose filter materials,  and packaging materials. The Company maintains
an inventory of raw materials  which, to date, has been acquired  primarily from
third parties. Currently, most raw materials are available from several sources.
The Company possesses the technical capability to produce its own antibodies and
has initiated  production  of  antibodies  for certain  tests.  However,  if the
Company were to change its source of supply for raw materials used in a specific
test,  additional  development,  and the accompanying  costs, may be required to
adapt the alternate material to the specific diagnostic test.

      6.      Patents, Trademarks, Licensing and Other Proprietary Information.

     Laboratory  Services.  The  Company  believes  that the basic  technologies
requisite to the  production of antibodies  are in the public domain and are not
patentable.  The Company intends to rely upon trade secret protection of certain

<PAGE>

proprietary information, rather than patents, where it believes disclosure could
cause the  Company  to be  vulnerable  to  competitors  who  could  successfully
replicate the Company's production and manufacturing techniques and processes.

     Product  Sales.  The  Company  has a patent  pending on the system  that it
developed which integrates  on-site  scientific  analysis with  state-of-the-art
data  collection and delivery.  The system is currently  being utilized with the
Company's PROFILE(R)-II and VERDICT(R)-II products.

                  The Company holds nine issued United States  patents  relating
to on-site testing  technology.  Eight of these patents generally form the basis
for the EZ-SCREEN and one-step  technologies  while the other patent  relates to
methods of utilizing whole blood as a sample medium on its immunoassay devices.

                  Of the eight U.S. patents mentioned above which generally form
the basis for the EZ-SCREEN and one-step technologies,  one expires in 2000, one
expires in 2004,  five expire in 2007, and one expires in 2010. The patent which
relates to the methods of utilizing  whole blood as a sample  medium  expires in
2012.

                  There can be no  guarantee  that there will not be a challenge
to the  validity of the patents.  In the event of such a challenge,  the Company
might be required to spend  significant  funds to defend its patents,  and there
can be no assurance that the Company would be successful in any such action.

                  General.  The Company holds  approximately 15 registered trade
names and/or  trademarks in reference to its products and corporate  names.  The
trade names and/or  trademarks of the Company range in duration from 10 years to
20 years with expiration dates ranging from 2001 to 2008. Applications have also
been made for additional trade names.

         7.       Seasonality.

                  Laboratory Services.  The Company believes that the laboratory
testing  business  is  subject  to  seasonal   fluctuations  in   pre-employment
screening.  These  seasonal  fluctuations  include  reduced volume in the summer
months,  year-end  holiday  periods,  and other  major  holidays.  In  addition,
inclement  weather may have a negative  impact on volume  thereby  reducing  net
revenues and cash flow.

     Product  Sales.  The  Company  does  not  believe  that  seasonality  is  a
significant factor in the sale of its on-site immunoassay testing devices.

         8.       Backlog.

                  Laboratory  Services.  There exists a delay in  recognition of
revenues  when setting up new accounts for  Laboratory  Services.  The time from
when an  account  becomes a client  of the  Company  to the time the  laboratory
starts  receiving  specimens  may be up to four  months.  The delay in receiving
samples  is  primarily  due  to  the  necessity  of  establishing  communication
capabilities  between the client and the Company,  the  requirement  to ship out
collection kits and forms,  and the  establishment of a collection site network.
At December 31, 1999, the Company had several accounts which were in the process
of being set up where revenues are not expected to be realized until 2000.
<PAGE>

     Product Sales. At December 31, 1999, MEDTOX Diagnostics,  Inc. did not have
any significant backlog and normally does not have any significant  backlog. The
Company  does not  believe  that sales  backlog is a  significant  factor in the
Product Sales segment of its business.

9.       Competition.

                  Laboratory Services.  As of December 31, 1999 approximately 66
labs,  including MEDTOX  Laboratories,  Inc. were certified by the Department of
Health and Human Services as having met the standards for Subpart C of Mandatory
Guidelines  for Federal  Workplace Drug Testing  Programs (59 FR 29916,  29925).
Competitors and potential  competitors  include  forensic testing units of large
clinical   laboratories   and  other   independent   laboratories,   specialized
laboratories, and in-house testing facilities maintained by hospitals.

                  Competitive factors include reliability and accuracy of tests,
price structure, service, transportation and collection networks and the ability
to establish relationships with hospitals,  physicians,  and users of drug abuse
testing programs. It should be recognized, however, that many of the competitors
and  potential  competitors  have  substantially  greater  financial  and  other
resources than the Company.

                  The industry in which the Company competes is characterized by
service issues  including,  turn-around  time of reporting  results,  price, the
quality  and  reliability  of  results,  and  an  absence  of  patent  or  other
proprietary  protection.  In addition,  since tests performed by the Company are
not protected by patents or other proprietary  rights,  any of these tests could
be performed by competitors.  However, there are proprietary assay protocols for
the more specialized testing that are unique to the Company.

                  The Company's  ability to  successfully  compete in the future
and maintain it margins will be based on its ability to maintain its quality and
customer   service  strength  while   maintaining   efficiencies  and  low  cost
operations.  There  can be no  assurance  that  price  competitiveness  will not
increase  in  importance  as a  competitive  factor  in the  laboratory  testing
business.

                  Product  Sales.  The  diagnostics  market  has  become  highly
competitive with respect to the price,  quality and ease of use of various tests
and is characterized by rapid technological and regulatory changes.  The Company
has  designed  its  on-site  tests  as  inexpensive,  on-site  tests  for use by
unskilled  personnel,  and has not  endeavored to compete with  laboratory-based
systems.  Numerous  large  companies  with  greater  research  and  development,
marketing,  financial,  and  other  capabilities,  as well as  government-funded
institutions and smaller  research firms,  are engaged in research,  development
and marketing of diagnostic  assays for  application  in the areas for which the
Company produces its products.

                  The Company has experienced increased competition with respect
to its immunoassay tests from systems and products developed by others,  many of
whom compete solely on price. As the number of firms marketing  diagnostic tests
has grown, the Company has experienced  increased price  competition.  A further
increase in competition  may have a material  adverse effect on the business and
future financial prospects of the Company.

         10.      Government Regulations.

     The products and services of the Company are subject to the  regulations of
a number of  governmental  agencies as listed  below.  It is  believed  that the

<PAGE>

Company is currently in compliance with all regulatory authorities.  The Company
cannot  predict  whether  future  changes  in  governmental   regulations  might
significantly  increase  compliance  costs or adversely  affect the time or cost
required to develop and introduce new products.

     1.  Substance  Abuse and Mental Health  Services  Administration  (SAMHSA).
MEDTOX  Laboratories,  Inc.  has been  certified  by SAMHSA  since 1988.  SAMHSA
certifies  laboratories  meeting strict  standards  under Subpart C of Mandatory
Guidelines for Federal Workplace Drug Testing Programs.  Continued certification
is accomplished  through periodic inspection by SAMHSA to assure compliance with
applicable regulations.

     2. United  States Food and Drug  Administration  (FDA).  Certain  tests for
human  diagnostic  purposes must be cleared by the FDA prior to their  marketing
for in vitro  diagnostic  use in the United States.  The FDA regulated  products
produced  by the  Company  are  in  vitro  diagnostic  products  subject  to FDA
clearance   through  the  510(k)   process  which  requires  the  submission  of
information and data to the FDA that demonstrates that the device to be marketed
is  substantially  equivalent  to a  currently  marketed  device.  This  data is
generated by performing  clinical  studies  comparing the results obtained using
the Company's device to those obtained using an existing test product.  Although
no  maximum  statutory  response  time  has  been  set for  review  of a  510(k)
submission,  as a matter of policy the FDA has  attempted to complete  review of
510(k)  submissions  within 90 days.  To date,  the Company has received  510(k)
clearance  for 12 different  products and the average time for  clearance was 72
days with a maximum  of 141 days and a minimum of 20 days.  Products  subject to
510(k) regulations may not be marketed for in vitro diagnostic use until the FDA
issues a letter stating that a finding of substantial equivalence has been made.

     As a registered  manufacturer  of FDA  regulated  products,  the Company is
subject  to a  variety  of FDA  regulations  including  the  Good  Manufacturing
Practices  (GMP)  regulations  which  define  the  conditions  under  which  FDA
regulated products are to be produced. These regulations are enforced by FDA and
failure to comply with GMP or other FDA  regulations  can result in the delay of
pre-market   product  reviews,   fines,  civil  penalties,   recall,   seizures,
injunctions and criminal prosecution.

     3. Health Care Financing  Administration  (HCFA).  The Clinical  Laboratory
Improvement Act (CLIA)  introduced in 1992 requires that all in vitro diagnostic
products  be  categorized  as  to  level  of  complexity.  A  request  for  CLIA
categorization  of  any  new  clinical  laboratory  test  system  must  be  made
simultaneously with FDA 510(k) submission.  The EZ-SCREEN,  PROFILE, PROFILE II,
VERDICT  and  VERDICT  II drugs of abuse  tests  currently  marketed  by  MEDTOX
Diagnostics,  Inc. have been categorized as moderately  complex.  The complexity
category to which a clinical  laboratory  test system is assigned  may limit the
number of laboratories  qualified to use the test system thus impacting  product
sales. MEDTOX Laboratories, Inc. is a CLIA licensed laboratory.

     4. Drug  Enforcement  Administration  (DEA).  The  primary  business of the
Company  involves  either testing for drugs of abuse or developing test kits for
the detection of drugs/drug  metabolites in urine. MEDTOX Laboratories,  Inc. is
registered with the DEA to conduct chemical analyses with controlled substances.
The MEDTOX Diagnostics,  Inc. facility in Burlington,  N.C. is registered by the
DEA to manufacture and distribute  controlled substances and to conduct research
with controlled substances. Maintenance of these registrations requires that the
Company comply with applicable DEA regulations.
<PAGE>

     5.  Additional   Laboratory   Regulations.   The   laboratories  of  MEDTOX
Laboratories,  Inc.  and certain of its  laboratory  personnel  are  licensed or
otherwise regulated by certain federal agencies, states, and localities in which
it conducts  business.  Federal,  state and local laws and  regulations  require
MEDTOX  Laboratories,  Inc. among other things, to meet standards  governing the
qualifications of laboratory owners and personnel, as well as the maintenance of
proper  records,  facilities,  equipment,  test  materials,  and quality control
programs.  In  addition,  the  laboratories  are  subject  to a number  of other
federal,   state,  and  local  requirements  which  provide  for  inspection  of
laboratory  facilities  and  participation  in proficiency  testing,  as well as
govern the transportation, packaging, and labeling of specimens tested by either
laboratory.   The   laboratories  are  also  subject  to  laws  and  regulations
prohibiting  the  unlawful  rebate  of fees and  limiting  the  manner  in which
business may be solicited.

     The laboratory  receives and uses small  quantities of hazardous  chemicals
and  radioactive  materials in their  operations  and are licensed to handle and
dispose of such chemicals and materials.  Any business  handling or disposing of
hazardous  and  radioactive  waste is subject  to  potential  liabilities  under
certain of these laws.

         11.      Product and Professional Liability.

                  Laboratory Services. The Company's laboratory testing services
are primarily diagnostic and expose the Company to the risk of liability claims.
The Company's  laboratories have maintained continuous  professional and general
liability  insurance  since 1984. The insurance  policy covers those amounts the
Company  is  legally  obligated  to pay from  damages  resulting  from a Medical
Incident,  which  arises out of a Failure to Render  Professional  Services.  To
date, the Company has not had any substantial  product liability and no material
professional service claims are currently pending.

                  Product Sales.  Manufacturing and marketing of products by the
Company entail a risk of product liability claims. In August,  1993, the Company
procured insurance coverage against the risk of product liability arising out of
events after such date, but such insurance does not cover claims made after that
date based on events that  occurred  prior to that date.  The  insurance  policy
covers  damages  that the Company is legally  obligated  to pay as a result from
bodily  injury and property  damage.  Consequently,  for uncovered  claims,  the
Company could be required to pay any and all costs  associated  with any product
liability claims brought against it, the cost of defense whatever the outcome of
the action, and possible settlement or damages if a court rendered a judgment in
favor of any plaintiff  asserting such a claim against the Company.  Damages may
include punitive  damages,  which may substantially  exceed actual damages.  The
obligation  to pay such  damages  could  have a material  adverse  effect on the
Company and exceed its ability to pay such damages.  No product liability claims
are pending.

         12.      Employees.

                  As  of  December  31,  1999,   the  Company  had  a  total  of
approximately  340 full time employee  equivalents as compared to  approximately
315 full time employee  equivalents at December 31, 1998. Of the approximate 340
employees, 309 work at and for MEDTOX Laboratories,  Inc. while the remaining 31
work at MEDTOX Diagnostics, Inc.

                  The  Company's  employees  are not  covered by any  collective
bargaining  agreements and the Company has not  experienced  any work stoppages.
The Company considers its relations with its employees to be good.
<PAGE>

ITEM 2.  PROPERTIES.
- ------   ----------

                  The administrative  offices and laboratory  operations for the
Laboratory  Services  segment of the Company's  business are located in a 53,576
square foot  facility in St.  Paul,  Minnesota.  The  facility is rented under a
lease which expires in March 2002. The current annual rent,  excluding operating
costs, for this facility is $445,000 per year.

                  The  operations for the Product Sales segment of the Company's
business are located in Burlington,  North Carolina where the Company  maintains
the offices, research and development laboratories,  production operations,  and
warehouse of MEDTOX  Diagnostics,  Inc. There the Company  leases  approximately
33,000 square feet. The current annual rent,  excluding  operating cost, paid by
the  Company for this  facility  is  approximately  $121,000.  This  facility is
currently  leased from Dr. Samuel C. Powell,  a member of the Board of Directors
of the Company.  The Company is currently  leasing the space on a month-to-month
basis and intends to  negotiate a new lease with Dr.  Powell in the near future.
The Company  believes it is renting  these  facilities  on terms as favorable as
those  available from third parties for equivalent  premises.  In the opinion of
management,   comparable   alternative  facilities  could  be  obtained  without
disruption of the business if a new lease with Dr. Powell is not negotiated.

                  The  Company  leases  administrative  offices  and  laboratory
facilities in an approximately  22,000 square foot facility in South Plainfield,
New Jersey. The rent payment,  excluding  operating costs, is $170,000 per year.
The  facility is  currently  idle but the lease  terminates  at the end of April
2000. The costs of the facility were  considered in the Company's  restructuring
charge in 1996.

                  The Company believes that its existing facilities are adequate
for the  purposes  being  used  to  accommodate  its  product  development,  and
manufacturing and laboratory testing requirements.

ITEM 3.  LEGAL PROCEEDINGS.
- ------   -----------------

                  In  February,  1999 the  Company  settled  a claim  of  patent
infringement   brought  against  the  Company  by  United  States  Drug  Testing
Laboratories on August 20,1996. The Company, while denying any infringement, has
settled the case by paying United States Drug Testing  Laboratories  $17,500 and
issuing  United States Drug Testing  Laboratories  2,500 shares of common stock.
The  Company  had  previously  accrued for this  contingency.  Accordingly,  the
settlement  of this  matter did not affect  results of  operations  for the year
ending December 31, 1999. Under the MEDTOX Laboratories  acquisition  agreement,
pursuant to which the Company originally acquired MEDTOX Laboratories, Inc., the
sellers of MEDTOX  Laboratories,  Inc.  agreed to remain  liable for any and all
damages for any patent  infringement which was alleged to have occurred prior to
the  closing  of  the  Company's  purchase  of  MEDTOX  Laboratories,  Inc.  The
acquisition  agreement  also  provided for the sellers to indemnify and hold the
Company  harmless  from and against any  damages,  loss,  liability  or expense,
including  reasonable  attorneys'  fees and court costs in  connection  with any
infringement  which was alleged to have occurred  before the closing date. It is
the Company's opinion that it is entitled to recover $79,000 in damages from the
sellers in accordance  with the above  referenced  provisions of the acquisition
agreement.  The Company  has made a formal  demand on the sellers for payment of
this $79,000 and plans to commence an arbitration proceeding against the sellers
if payment of the $79,000 is not made.
<PAGE>

                  On  January  31,  1997,  the  Company  filed  suit in  Federal
District Court in Minnesota against Morgan Capital LLC, David Bistricer and Alex
Bistricer  alleging  violation of Section 16b of the Securities and Exchange Act
of 1934 and seeking  recovery  of more than  $500,000  in  short-swing  profits.
Messrs.  David and Alex Bistricer are former directors of the Company. On August
4, 1997,  the U.S.  District  Court  dismissed  the  Company's  complaint and on
October 29,  1997,  the Company  filed an appeal of that  decision to the United
States Court of Appeals for the Eighth  Circuit.  On July 21,  1998,  the Eighth
Circuit  reversed  the  District  Court  dismissal  and remanded the case to the
District  Court.  On June 3, 1999 the U.S.  District  Court  found  that  Morgan
Capital had violated Section 16(b) and ordered Morgan Capital to pay the Company
damages of $551,000  plus  interest.  The  parties are now engaged in  discovery
regarding the individual  claims by the Company against David and Alex Bistricer
personally.  Once the claims against the Bistricers have been adjudicated, it is
anticipated that Morgan Capital and the Bistricers will appeal any damage awards
to the Eighth Circuit unless the parties are able to reach a final settlement of
all claims. The Company has not recorded a receivable for this amount due to the
uncertainty of this matter.

                  In May of 1999 the Company  settled a lawsuit  brought against
the  Company  by a  previous  landlord  in the  Circuit  Court  of Cook  County,
Illinois.  The landlord  alleged that the Company  breached the terms of a lease
the Company was required to assume in connection with an asset acquisition.  The
Company  settled this matter for  $685,000  which was less then the $850,000 the
Company had  previously  accrued for this  contingency at December 31, 1998. The
difference  between the original  accrual and the actual  settlement  amount was
recorded in the second quarter of 1999 as a reduction in restructuring costs.

ITEM 4.  SUBMISSION OF MATTERS TO VOTE OF SECURITY HOLDERS.
- ------   -------------------------------------------------

                  The Company held a special meeting of stockholders on February
22, 1999 to adopt and  approve an  amendment  of the  Company's  Certificate  of
Incorporation providing for a one-for- twenty reverse stock split of outstanding
Common Stock of the Company.  The  amendment was approved by a vote of 2,309,935
in favor and 162,644  against.  The reverse  split was effective on February 23,
1999 and the common stock began trading on the new basis  February 24, 1999. All
shares and per share  amounts  presented in the Annual  Report on Form 10-K have
been adjusted to reflect the reverse split.

                  The  Annual  Meeting  (the  "1999  Annual   Meeting")  of  the
stockholders of the Company was held on September 16, 1999. At that meeting,  by
a vote of 1,468,805 shares in favor and 120,703 shares against, the stockholders
approved  an  amendment  to  Article  FIFTH  of  the  Company's  Certificate  of
Incorporation to provide for the  classification  of the Board of Directors into
three classes of directors with staggered terms of office.  With respect to this
matter,  1,313,739  shares  abstained  or did not  vote.  At that  meeting,  the
stockholders  then elected the  following  individuals  to serve on the Board of
Directors of the Company until their respective  successors are duly elected and
qualified in the  following  classifications:  Class I, to hold office until the
Annual Meeting in 2000, Miles E. Efron and Samuel C. Powell,  Ph.D; Class II, to
hold office until the Annual Meeting in 2001, James W. Hansen;  and Class III to
hold  office  until the Annual  Meeting  in 2002,  Richard A. Braun and Harry G.
McCoy,  Pharm.D.  Also by a vote of 2,404,280 shares in favor and 146,104 shares
against,  the stockholders of the Company approved an amendment to the Company's
Employee  Stock  Purchase  Plan to increase from 25,000 to 150,000 the number of
shares  authorized  to be issued  pursuant  to that Plan.  With  respect to this
matter,  352,863  shares  abstained  or did  not  vote.  Finally,  by a vote  of
2,333,440  shares in favor and 238,818 shares against,  the  stockholders of the
Company approved an amendment to Article FOURTH of the Company's  Certificate of
Incorporation  to increase its number of authorized  common stock from 3,750,000

<PAGE>

shares  to  7,400,000  shares.  With  respect  to this  matter,  330,989  shares
abstained or did not vote.

                  During fiscal year 1999, no other matters were  submitted to a
vote of the securities holders of the Company.

<PAGE>


                                     PART II

ITEM 5.   MARKET FOR THE REGISTRANT'S COMMON EQUITY AND RELATED STOCKHOLDER
          MATTERS.
- ------    ---------------------------------------------------------------------

Common Stock

     Since  September 27, 1993, the Common Stock has been listed on the American
Stock Exchange and is currently  trading under the symbol "TOX".  From September
16, 1992 to September  26, 1993 the Common Stock was traded in and quoted in the
Emerging  Company  Marketplace of the American Stock Exchange  ("ECM") under the
trading symbol  "EDI.EC".  As of March 15, 2000, the number of holders of record
of the Common Stock was 2,658.  The following tables set forth, for the calendar
quarters  indicated,  the high and low  closing  price per share for the  Common
Stock,  as  reported  by the  American  Stock  Exchange.  The  quotations  shown
represent inter dealer prices without  adjustment for retail markups,  markdowns
or commissions,  do not necessarily reflect actual  transactions,  and have been
adjusted for the 1:20 reverse split which took effect on February 24, 1999.

         2000:  (through March 15, 2000)             High              Low
         ----                                        ----              ---
         First Quarter...................           10 1/8            8 1/2

         1999:                                       High              Low
         ----                                        ----              ---
         First Quarter... .................          5                 2 9/16
         Second Quarter...............               7 1/2             2 5/8
         Third Quarter...........................   10 1/16            6 1/2
         Fourth Quarter..................            9 5/8             7 1/4

         1998:

         First Quarter............................   7 1/2             5
         Second Quarter........................      8 3/4             5
         Third Quarter...........................    8 3/4             5
         Fourth Quarter.........................     7 1/2             3 3/4


                  On March 15,  2000,  the closing  price of the Common Stock as
reported by the American Stock Exchange was $8 7/8.

               No cash dividends have been declared or paid by the Company since
its inception and  management of the Company has no plans to pay a cash dividend
in the  foreseeable  future.  The Company's  financial  covenants under its debt
instrument may effectively preclude the Company from paying cash dividends.

               On  September  18,  1998,   the  Company's   Board  of  Directors
authorized  and declared a dividend of one preferred  share  purchase  right for
each share of common stock then outstanding. Subsequent to that date the Company
maintains a plan in which one preferred  share purchase right (Right) exists for
each common share of the Company.  These Rights are exercisable only if a person
or group  acquires  beneficial  ownership of 20 percent or more of the Company's
outstanding common stock.
<PAGE>

Series A Preferred Stock

                  To help finance the  acquisition of the  predecessor to MEDTOX
Laboratories, Inc. and provide working capital, the Company issued 407 shares of
Series A Preferred  Stock in January  1996.  There are  currently  no  remaining
shares of Series A Preferred Stock outstanding.

                  The Series A Preferred  Stock was  convertible  into shares of
Common Stock,  at any time from March 30, 1996, the 60th day after the shares of
Series A  Preferred  Stock  were  first  issued  by the  Company  (the  "Initial
Conversion Date"), until January 30, 1998, the second anniversary of the Initial
Preferred  Issuance Date, at which time all conversion  rights  terminated.  The
Series A  Preferred  Stock  had no  voting  power  and had  certain  liquidation
preference  and dividend  rights.  The number of shares of Common Stock issuable
upon  conversion  of a share of Series A  Preferred  Stock  equaled  the  number
derived by  dividing  (i) the  purchase  price of the Series A  Preferred  Stock
($50,000  per  share) by the lesser of (i) $2.775  (based on  pre-reverse  split
market price) or (ii) 75% of the Market Price of the Common Stock on the day the
shares of Series A Preferred  Stock were  converted  into Common Stock.  "Market
Price" is defined  for this  purpose as the daily  average  of the  closing  bid
prices  quoted on the  American  Stock  Exchange or other  exchange on which the
Common Stock is traded for the five trading days immediately  preceding the date
the shares are converted.

                  No dividends on the Series A Preferred  Stock were declared or
paid prior to their conversion to Common Stock.

Subordinated Debt

                  As of December 31, 1999 the Company had received $575,000 from
private placements of subordinated debt, with a maturity date of March 31, 2001.
$175,000 was received in the fourth quarter of 1998 with the remaining  $400,000
received in the first quarter of 1999.  The debt carries an interest rate of 12%
and has  accompanying  warrants to  purchase a number of shares of common  stock
equal to 25% of the notes purchased at an exercise price per share of $3.25.

ITEM 6.  SELECTED FINANCIAL DATA.

                  The  following  selected  financial  data is derived  from the
consolidated  financial  statements  of  the  Company  and  should  be  read  in
conjunction with the consolidated financial statements, related notes, and other
financial information included herein.

     In evaluating financial performance,  management focuses on net income as a
segment's measure of profit or loss. The accounting policies of the segments are
the same as those  described in the summary of significant  accounting  policies
included in Note 1 to the Consolidated Financial Statements.

SEGMENT INFORMATION (IN THOUSANDS)

                                 Lab Services       Product Sales         Total

 1999

 NET REVENUES                        31,012             3,991            35,003
 SEGMENT INCOME  (LOSS)               1,440              (21)             1,419
 DILUTED EARNINGS PER COMMON SHARE                                         0.48
 SEGMENT ASSETS                      24,269             2,002            26,271

<PAGE>
                                 Lab Services       Product Sales         Total
 1998

  NET REVENUES                        27,070             2,505           29,575
  SEGMENT  LOSS                       (1,391)            (906)          (2,297)
  DILUTED LOSS PER COMMON SHARE                                          (0.79)
  SEGMENT ASSETS                      23,289             1,311           24,600

1997

 NET REVENUES                        25,899             2,695            28,594
 SEGMENT INCOME (LOSS)                  430              (405)               25
 DILUTED EARNINGS PER COMMON SHARE                                         0.01
 SEGMENT ASSETS                      23,469             1,412            24,881

1996

 NET REVENUES                        23,541             3,047            26,588
 SEGMENT LOSS                        (9,155)           (3,653)          (12,808)
 DEEMED DIVIDEND ON PREF. STOCK                                          (6,783)
 DILUTED LOSS PER COMMON SHARE                                            (0.59)
 SEGMENT ASSETS                      22,479             1,601            24,080

1995

 NET REVENUES                          4,612             2,914            7,526
 SEGMENT LOSS                         (2,614)           (7,283)          (9,897)
 DILUTED LOSS PER COMMON SHARE                                            (0.77)
 SEGMENT ASSETS                        1,751             2,187            3,938



ITEM 7.           MANAGEMENT'S DISCUSSION AND ANALYSIS
                  OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS.

General

                  The Company  commenced  operations in June 1983 and until 1986
was a development  stage company.  The Company became engaged in the manufacture
and sale of products  as a result of its  acquisition  of Granite  Technological
Enterprises,  Inc. in June 1986. The Company began the  manufacture  and sale of
its EZ-SCREEN  diagnostic  tests in 1985 and  introduced  its patented  one-step
assay,  VERDICT and RECON, in 1993. In February 1994, the Company  completed the
acquisition of PDLA. In January 1996, the Company  completed the  acquisition of
the assets of the predecessor of MEDTOX Laboratories,  Inc. Since inception, the
Company has financed its working capital requirements primarily from the sale of
equity securities and more recently through debt financing.
<PAGE>

Year Ended December 31, 1999 Compared to Year Ended December 31, 1998

Laboratory Services

                  Revenues from Laboratory  Services for the year ended December
31, 1999 were $31,012,000 as compared to $27,070,000 for the year ended December
31, 1998.  The increase of 14.6% was  primarily  attributable  to an increase of
19.2% in laboratory  tests for employment drug testing  services.  This increase
was due to increased sales from current clients as well as new clients.  Revenue
from the  increase in test volume was  partially  offset by an 8.0%  decrease in
average per unit prices.

                  The  gross  margin  from  the  revenues   generated  from  the
Laboratory  Services was 33.7% for the year ended  December 31, 1999 as compared
to a gross  margin of 30.9% for the same period in 1998.  The  increase in gross
margin was primarily due to cost savings and  improvements  in the efficiency of
laboratory  operations  which more than offset the 8.0%  decrease in average per
unit prices.

                  Selling,  general  and  administration  expenses  for the year
ended  December 31, 1999 were  $8,092,000,  compared to $7,929,000  for the year
ended  December 31, 1998. The increase of $163,000 or 2.1% in 1999 was primarily
the result of  increased  costs in the sales and  marketing  area related to the
increased sales volume.  However,  these increases were substantially  offset by
the  overall  reduction  in  general  and  administrative  expenses  due  to the
Company's continued efforts to reduce and monitor operating costs.

                  Research and  development  expenses  incurred  during the year
ended  December  31, 1999 were  $316,000  as  compared to $522,000  for the same
period in 1998.  This  decrease of $206,000 was  primarily the result of a fewer
number of  laboratory-based  assays  being  develop in 1999 as compared to those
developed in 1998.

                  The  Laboratory  Services  segment for the year ended December
31, 1999,  incurred interest and financing costs of $752,000,  compared to costs
of $615,000  incurred  during the year ended December 31, 1998. This increase of
$137,000 or 22.3% was primarily due to the increase in debt attributable to this
segment of the Company's operations.

               The Company used $686,000 of its restructuring  reserve in fiscal
1999,  which  reduced the  remaining  balance of this  reserve to $469,000 as of
December 31, 1999.  The  reduction in the  restructuring  reserve in fiscal 1999
were due to payments of $522,000 and a decrease in the reserve by an  additional
$164,000,  as a result of the settlement of certain  litigation  brought against
the  Company  for  less  than  the  Company  had  previously  accrued  for  this
contingency in 1998. The $164,000  adjustment was recorded in the second quarter
of 1999 as a reduction in restructuring costs.

                  As a result of the above,  the net  income for the  Laboratory
Services  segment  of the  Company  for the year  ended  December  31,  1999 was
$1,440,000  compared to a net loss of ($1,391,000),  for the year ended December
31, 1998.

Product Sales

                  Revenues  from  Product  Sales  segment  for  the  year  ended
December 31, 1999 increased by 59.3% to $3,991,000 as compared to $2,505,000 for

<PAGE>

the year ended December 31, 1998. The increase was primarily attributable to the
significant  growth in sales of the  PROFILE(R)-  II and  VERDICT(R)- II on-site
testing kits.

                  Product Sales include the sales generated from substance abuse
testing  products,  which  incorporates the EZ-SCREEN  PROFILE,  PROFILE(R)- II,
VERDICT and  VERDICT(R)- II on-site test kits and other  ancillary  products for
the detection of abused substances. Sales from these products increased 90.5% to
$2,471,000  for the year ended December 31, 1999 compared to sales of $1,297,000
in 1998.  The Company  believes  that the  introduction  of  PROFILE(R)-  II and
VERDICT(R)-  II, its new  generation  of on-site test kits along with its patent
pending  "test  system" has placed the Company in a strong  position  to compete
successfully in the on-site drug screening market.

                  Product  Sales also include sales of  agricultural  diagnostic
products. Sales of these products increased 19.7% to $548,000 for the year ended
December  31 1999,  compared to  $458,000  in 1998.  The primary  reason for the
increase of $90,000 was the result of  increased  purchases  by the USDA for the
Company's  products.  The USDA's needs for the Company's products vary from year
to year and sales to the USDA are expected fluctuate accordingly.

                  Sales of contract manufacturing services,  microbiological and
associated  products increased 29.6% to $972,000 for the year ended December 31,
1999 compared to $750,000 in 1998.  This increase was due to increased  revenues
from both historical customers and new customers.

                    Gross margins from Product Sales for the year ended December
31, 1999 were 45.5%  compared to 33.3% for the year ended December 31, 1998. The
increase in gross margin from Product Sales was due to the substantial  increase
in overall  sales of  products  with a higher  gross  margin,  particularly  the
substance abuse testing products.

                  Revenues  from  interest  and other income for the years ended
December 31, 1999 and December 31, 1998 was approximately $1,000 for both years.

                  Selling,  general and  administration  expenses  for  products
sales  during the year ended  December  31,  1999 were  $1,256,000  compared  to
$1,045,000  for the year ended  December 31,  1998.  The increase of $211,000 or
20.2% was primarily due to increased sales and marketing expenses as a result of
implementation  costs associated with the introduction and sale of the Company's
new generation on-site products.

                  Research and  development  expenses  incurred  during the year
ended  December  31, 1999 were  $518,000  as  compared to $631,000  for the same
period in 1998.  The decrease of $113,000 or 17.9% was  primarily  the result of
the completion of a significant portion of the development costs associated with
the Company's new generation of on-site products.

                  For the year  ended  December  31,  1999,  the  Product  Sales
segment incurred  interest and financing costs of $65,000 as compared to $59,000
for the same period in 1998.

                  As a result of the above,  the Product  Sales segment net loss
for the year ended December 31, 1999 was ($21,000),  compared to the net loss of
($906,000) for the year ended December 31, 1998.
<PAGE>

Year Ended December 31, 1998 Compared to Year Ended December 31, 1997

Laboratory Services

                  Revenues from Laboratory  Services for the year ended December
31, 1998 were $27,070,000 as compared to $25,899,000 for the year ended December
31, 1997. The increase of 4.5% was primarily  attributable  to increase of 16.5%
in laboratory  samples for employment drug testing  services.  This increase was
due to increased sales from current clients as well as new clients. Revenue from
increase in sample volume was partially  offset by an 11.3%  decrease in average
per unit prices.

                  The  gross  margin  from  the  revenues   generated  from  the
laboratory  services was 30.9% for the year ended  December 31, 1998 as compared
to a gross  margin of 37.5% for the same  period in 1997.  The  decline in gross
margin was primarily due to increased  costs  related to  implementation  of new
tests and a decrease in the average  selling price per  laboratory  sample.  The
decrease  in average  realized  selling  price was  partially  offset by savings
realized  from cost savings and  improvements  in the  efficiency  of laboratory
operations.

                  Selling,  general  and  administration  expenses  for the year
ended  December 31, 1998 were  $7,929,000,  compared to $7,780,000  for the year
ended December 31, 1997. The increase of $149,000 or 1.9% in 1998 was the result
of  increased   costs  in  several  areas   including;   $379,000  in  increased
depreciation  expense,  $133,000 in increased group insurance  costs, a $123,000
increase  in  computer  information  systems  expense,  and  severance  expenses
totaling  $167,000  related to staff  resizing.  These  increases were partially
offset by savings of $564,000 realized from reduced sales and marketing expenses
due to a restructuring of the sales and marketing group and an overall effort to
reduce and monitor costs.

                  Research and  development  expenses  incurred  during the year
ended  December  31, 1998 were  $522,000  as  compared to $502,000  for the same
period in 1997.  This  increase of $20,000 was primarily the result of increased
in personnel costs due to scheduled salary increases.

                  The  Laboratory  Services  segment for the year ended December
31, 1998,  incurred interest and financing costs of $615,000,  compared to costs
of $609,000 incurred during the year ended December 31, 1997.

               The Company's restructuring reserve increased by $712,000 for the
year ended  December 31, 1998 as compared to the period ended December 31, 1997.
The increase in the reserve was due to an increase in the  projected  litigation
and settlement  expenses relating to a lawsuit brought by a previous landlord in
the Circuit Court of Cook County,  Illinois. In December 1998, the Court granted
summary  judgment  against  the Company on the issue of  liability.  The Company
settled this matter in May 1999 for $685,000.

                  As a result  of the  above,  the net  loss for the  Laboratory
Services  segment  of the  Company  for the year  ended  December  31,  1998 was
($1,391,000), compared to the net income of $430,000 for the year ended December
31, 1997.

Product sales

                  Revenues  from Product  Sales for the year ended  December 31,
1998  decreased  7.1% to $2,505,000 as compared to $2,695,000 for the year ended

<PAGE>

December 31, 1997. The decrease was primarily attributable to decreased sales in
substance abuse testing products and agricultural diagnostic products.

                  Product sales include the sales generated from substance abuse
testing products, which incorporates the EZ-SCREEN,  PROFILE and VERDICT on-site
test kits and other ancillary  products for the detection of abused  substances.
Sales from  these  products  decreased  15.0% to  $1,297,000  for the year ended
December 31, 1998 compared to sales of $1,525,000 in 1997. The Company  believes
that the decrease in product sales was  primarily  due to increased  competition
from products  perceived as more user  friendly  than the Company's  traditional
products.  The Company also believes that the introduction of its new generation
of on-site test kits along with its patent  pending "test system" has placed the
Company in strong position to compete successfully in the on-site drug screening
market.  The first of these next generation test kits,  PROFILE(R)- II, received
pre-market  510(k)  clearance  from the U.S. Food & Drug  Administration  in the
fourth quarter of 1998.

                  Product  sales also include sales of  agricultural  diagnostic
products. Sales of these products decreased 37.8% to $458,000 for the year ended
December  31 1998,  compared to  $736,000  in 1997.  The primary  reason for the
decrease of $278,000 was the result of  decreased  purchases by the USDA for the
Company's  products.  The USDA's needs for the Company's products vary from year
to year and sales to the USDA are expected fluctuate accordingly.

                  Sales of contract manufacturing services,  microbiological and
associated  products increased 72.8% to $750,000 for the year ended December 31,
1998 compared to $434,000 in 1997.  This increase was due to increased  revenues
from both historical customers and new customers added in late 1997.

     Gross margins from Product Sales for the year ended  December 31, 1998 were
33.3%  compared to 37.0% for the year ended  December 31, 1997.  The decrease in
gross margin from product  sales was due to lower  overall sales of products and
increased manufacturing costs related to new product development.

                  Revenues  from  interest  and other  income for the year ended
December 31, 1998 were $1,000 compared to $6,000 for the year ended December 31,
1997.

                  Selling,  general and  administration  expenses  for  products
sales  during the year ended  December  31,  1998 were  $1,045,000,  compared to
$946,000 for the year ended  December 31, 1997. The increase of $99,000 or 10.5%
was  primarily  the  result  of   implementation   costs   associated  with  the
introduction of the Company's new generation on-site products.

                  Research and  development  expenses  incurred  during the year
ended  December  31, 1998 were  $631,000  as  compared to $463,000  for the same
period in 1997.  The increase of $169,000 or 36.5% was  primarily  the result of
costs  associated with the  development of the Company's new generation  on-site
products.

                  For the year  ended  December  31,  1998,  the  Product  Sales
segment incurred interest and financing costs of $59,000. There were no interest
charges  incurred by this segment  during the year ended  December 31, 1997. The
interest and finance costs were the result of the funds  borrowed by the Company
to fund asset purchases and working capital requirements.
<PAGE>

                  As a result of the above,  the product  sales segment net loss
for the year ended December 31, 1998 was  ($906,000),  compared to a net loss of
($405,000) for the year ended December 31, 1997.

Material Changes in Financial Condition

Laboratory Services

                  At December 31, 1999,  net accounts and notes  receivable  for
Laboratory  Services  were  $6,318,000.  This  $748,000,  or 13.4%  increase  as
compared to $5,570,000 at December 31, 1998 was a result of an increase in gross
billings prior to pass through costs,  in the fourth quarter of 1999 as compared
to the same quarter in 1998.

                  Inventories  were  $734,000 at December  31, 1999  compared to
$432,000 at December  31,  1998.  This  $302,000 or 69.9%  increase  was largely
attributable  to the  stockpiling  of  additional  inventory to protect  against
delivery  problems from key  suppliers due to "Year 2000"  problems that did not
materialize.

                  Prepaid  expenses and other  assets were  $914,000 at December
31, 1999 as compared to $503,000 at December  31, 1998.  This  $411,000 or 81.7%
increase  was  primarily  the  result  of the  down  payment  on a  consultant's
contract,  deposits on items of equipment  which were not yet  operational as of
year  end and an  increase  in  prepaid  supplies  in part  in  anticipation  of
potential   delivery   problems  due  to  "Year  2000"  problems  that  did  not
materialize.

                  The balance of gross  equipment and  improvements  at December
31, 1999 was $11,299,000 as compared to a balance of $10,275,000 at December 31,
1998.  This  $1,024,000,  or 10.0%  increase  was the  result  of  purchases  of
equipment  and capital  improvements  for the  laboratory  operation  to improve
efficiencies and reduce operating costs.

                  Goodwill, net of accumulated amortization, totaled $13,161,000
and  $14,007,000  as of  December  31, 1999 and 1998  respectively.  The Company
periodically  undertakes  a  review  of  the  value  of the  remaining  goodwill
associated  with the acquisition of MEDTOX  Laboratories,  Inc., to determine if
the  value  is  supported  by the  projected  future  undiscounted  cash  flows.
Utilizing an undiscounted  cash flow analysis,  the Company  determined that the
carrying   value  of  the  remaining   goodwill   associated   with  the  MEDTOX
Laboratories,  Inc.  acquisition  is  supported by the  projected  cash flows at
December 31, 1999.

                  As of December 31, 1999,  accounts payable totaled  $3,518,000
compared to $3,345,000 at December 31, 1998.  The increase of $173,000,  or 5.2%
is primarily due to the 22.9% increase in laboratory sales in the fourth quarter
of 1999 as compared to the same period in 1998.

                  Accrued  expenses  were  $1,419,000  at December 31, 1999,  as
compared to $1,586,000 at December 31, 1998.  The decrease of $167,000,  was the
result of decrease in the accrual for various  employee related expense incurred
in 1998, due to severance packages and moving allowances.

                  At December 31, 1999,  the Laboratory  Services  segment had a
total balance of capital  leases  payable of $595,000,  compared to a balance of
$702,000 at December 31, 1998. The decrease in the balance of the capital leases
payable was the result of the  amortization  of existing  capital leases in 1999

<PAGE>

and the emphasis on the use of bank financing for most of the Company's  capital
equipment needs.

     At  December  31,  1999,   Laboratory  Services  had  a  total  balance  of
restructuring  accruals  of  $469,000  compared  to a balance of  $1,155,000  at
December 31, 1998. The decrease in the balance of the restructuring  accruals of
$686,000,  or 59.4%,  was the result of the  payment  of  various  restructuring
expense  during  the year plus the  reduction  in the  accrual  to  reflect  the
settlement  of  certain  pending  litigation  for an  amount  less than what the
Company had initially accrued for such litigation.

                  At December  31,  1999,  Laboratory  Services had a total loan
balance owed to the  Company's  financial  lender of  $5,952,000,  compared to a
total  balance of  $5,120,000  owed at December  31,  1998.  The net increase of
$832,000,  or 16.3%,  was  primarily  the result of increased  borrowings by the
Company from its line of credit to pay operating expenses as well as to fund the
purchases of certain assets to improve operating efficiencies.

                  At  December  31,  1999 the Company had a total of $537,000 in
12% subordinated  debentures  outstanding as compared to $148,000 as of December
31, 1998. This increase was the result of additional  sales of the  subordinated
debentures in the first quarter of 1999. The proceeds from the  debentures  were
used to fund  operations  and make capital  purchases in 1999 in the  Laboratory
Services segment.

Product Sales

                  At December 31,  1999,  net  accounts  receivable  for Product
Sales were $789,000. This $372,000, or 89.2% increase as compared to $417,000 at
December 31, 1998 was a result of a similar  percentage  increase in billings in
the fourth quarter of 1999 as compared to the same quarter in 1998.

                  Inventories  were  $818,000 at December  31, 1999  compared to
$675,000  at  December  31,  1998.   This   increase  of  $143,000  was  largely
attributable  to the need to  increase  inventory  to  support  the  substantial
increase in product sales in 1999 and also due to the  stockpiling of additional
inventory to protect against  delivery  problems from key suppliers due to "Year
2000" problems that did not materialize.

                  Prepaid  expenses and other  assets were  $145,000 at December
31, 1999 as compared to $21,000 at December 31,  1998.  The increase of $124,000
is primarily the result of the deposits made on equipment  purchased but not yet
operational as of year end and prepayment of certain supplies expenses for items
that will actually be used in subsequent periods.

                  The balance of gross  equipment and  improvements  at December
31, 1999 was  $2,875,000  as compared to a balance of $2,787,000 at December 31,
1998. The increase of $88,000 was the result of equipment  purchases  during the
year.

                  As of December 31, 1999,  accounts  payable  totaled  $164,000
compared to $186,000 at December 31, 1998. The decrease of $22,000, or 11.8%, is
primarily the result more timely payment of outstanding invoices by this segment
of the Company.

                  Accrued  expenses  were  $135,000 at  December  31,  1999,  as
compared to $138,000 at December 31, 1998.
<PAGE>

                  At December  31, 1999,  the Product  Services had a total loan
balance owed to its financial lender of $692,000, compared to a total balance of
$752,000 owed at December 31, 1998.  The net decrease of $60,000,  or 8.0%,  was
the result of payments  made  during the year and the lower  level of  financing
required by the Product  Sales  segment of the business due to its  particularly
strong sales growth in 1999.

Liquidity and Capital Resources

                  The working  capital  requirements  of the  Company  have been
funded primarily by cash received from debt financing. Cash and cash equivalents
at December 31, 1999 were $576,000, compared to $0 as of December 31, 1998.

                  The  Company is relying on  expected  positive  cash flow from
operations,  its line of credit,  in addition  to funds  received  from  private
placements  of  subordinated  debt (see  discussion  below)  to fund its  future
working capital and asset purchases.  The amount of credit on the revolving line
of credit is based  primarily  on the  receivables  of the Company and, as such,
varies with the accounts receivable, and to a lesser degree the inventory of the
Company.  As of  December  31,  1999,  the  Company  had total  availability  of
$5,228,000 on its line of credit of which $4,208,000 was borrowed, leaving a net
availability of $1,020,000 as of December 31, 1999.

                  On  January  14,  1998,  the  Company  entered  into a  Credit
Security  Agreement  (the  "Wells  Fargo  Credit  Agreement")  with Wells  Fargo
Business  Credit  (Wells  Fargo).  The Wells Fargo Credit  Agreement as amended,
consists of (i) a term loan of  $2,125,000,  bearing  interest at prime + 1.25%:
(ii) an overadvance term loan of $700,000, bearing interest at prime + 3%; (iii)
a  revolving  line of credit  equal to the  lesser of  $6,000,000  or 80% of the
Company's  eligible trade accounts  receivable,  bearing interest at prime + 1%,
and (iv) a note of up to  $1,200,000,  for the  purchase  of  capital  equipment
bearing interest at prime + 1.25%.

                  As of December  31, 1999 the Company  received  $175,000  from
private  placements  of  subordinated  debt.  The notes  require  payment of the
principal  amount  on  December  31,  2001.  Interest  at 12% per  annum is paid
semiannually  on June 30 and December 31. In connection with the issuance of the
subordinated  notes,  the Company issued warrants to purchase a number of shares
of common stock equivalent to 25% of the face amount of the  subordinated  notes
divided by the warrant  exercise price per share.  The warrants are  exercisable
form  December  15, 1999 to December 31, 2001 and the initial  warrant  exercise
price was $5.00 per share. In February 1999, the warrant agreements were amended
to decrease the exercise  price to $3.25 per share.  The Company has  determined
the value of the  warrants at the date of grant to be $27,000.  The value of the
warrants has been accounted for as additional  paid-in-capital and deducted from
the principal of the subordinated notes as discount on debt issued.

     During the first  quarter  or 1999,  the  Company  received  an  additional
$400,000 from private placement of subordinated debt under the same terms as the
December  1998  debt  issuance.  The  Company  has  determined  the value of the
warrants as of the date of the loan to be $29,000. The value of the warrants has
been accounted for as additional paid-in-capital and deducted from the principal
of the subordinated notes as discount on debt issued

                  The funds  received from the Wells Fargo Credit  Agreement and
the  private  placements  of  subordinated  debt were  used to fund the  working
capital needs of the Company.
<PAGE>

                  In  the   short   term,   the   Company   believes   that  the
aforementioned   capital  along  with   additional   funds   received  from  the
subordinated  debt offering  will be  sufficient  to fund the Company's  planned
operations  through  2000.  While there can be no assurance  that the  available
capital will be sufficient to fund the future  operations of the Company  beyond
2000, the Company  believes that consistent  profitable  operations,  as well as
access to capital,  will be the primary basis for funding the  operations of the
Company for the long term.

                  The  Company  continues  to follow a plan which  includes  (i)
continuing to aggressively  monitor and control costs,  (ii) increasing  revenue
from sales of the Company's existing products and services (iii) the development
of new products and  services,  as well as (iv) continue to  selectively  pursue
synergistic  acquisitions to increase the Company's  critical mass. There can be
no assurance that costs can be controlled,  revenues can be increased, financing
may be obtained, acquisitions successfully consummated, or that the Company will
be profitable.

Impact of Year 2000

                  The "Year 2000"  issue arose from the fact that many  computer
systems  relied at one time on a two-digit  date code to identify the year (e.g.
98 to represent 1998) and, thus, there was concern that these systems may not be
able to differentiate between the year 2000 and the year 1900. If not corrected,
there was serious  concern that systems  processing  date-dependent  information
might fail or create  erroneous  results,  causing  disruptions  of  operations,
including,  but not limited to, a temporary  inability to process  transactions,
report results, send invoices, or engage in similar normal business activity.

     The Company created a task force representing all departments with the goal
of achieving an  uninterrupted  transition  into calendar year 2000. The Company
has no products with embedded  computer  chips or  date-sensitive  controls and,
therefore,  does not believe there are any "Year 2000" compatibility issues with
the  Company's  products.  The  Company has been in  communication  with its key
suppliers  regarding  "Year 2000" issues.  No  interruptions  in operations were
caused by any key  suppliers of the Company.  The Company  believes that it will
not experience any  significant  operational  problems due to "Year 2000" issues
for its key suppliers in the future.

                  To  date,   the  Company  has  not   experience  any  material
consequences  as a  result  of the  "Year  2000"  issue.  The  Company  does not
anticipate that it will experience any material impact in the future as a result
of the  "Year  2000"  issue.  However,  there  can be no  assurances  that  such
consequences  will not occur with the passage of time. The Company continues to
monitor all of its  computer  operating  systems and related  processes to guard
against interruption to the operation of its computer systems.

                  The Company has used primarily  internal resources and delayed
other projects while  completing its "Year 2000" readiness  program.  Updates to
internally  supported  software  were  generally  covered  by  existing  service
contracts.  The total cost of the Company's  "Year 2000" efforts through the end
of 1999 were less than $50,000 and relate primarily to software license fees and
new hardware and equipment  updates.  This amount excludes costs associated with
internal work done by Company employees.
<PAGE>

ITEM 7A.          QUALITATIVE AND QUANTITATIVE DISCLOSURES ABOUT MARKET RISK.

                  Market risk is the risk that the Company will incur losses due
to adverse changes in interest rates or currency exchange rates and prices.  The
Company's primary market risk exposures are to changes in interest rates. During
1999,  1998 and 1997,  the  Company  did not have sales  denominated  in foreign
currencies nor did it have any  subsidiaries  located in foreign  countries.  As
such,  the  Company  is not  exposed to market  risk  associated  with  currency
exchange rates and prices.

                  The Company had $575,000 and  $175,000 of  subordinated  notes
outstanding as of December 31, 1999 and 1998, respectively,  at a fixed interest
rate of 12% per annum.  The  Company  also had capital  leases at various  fixed
rates.  These  financial  instruments are subject to interest rate risk and will
increase or decrease in value if market interest rates change.

                  The Company had  approximately  $6.6  million and $5.9 million
outstanding  on its line of credit and  long-term  debt  issued  under the Wells
Fargo  Credit  Agreement  as of December  31, 1999 and 1998.  The debt under the
Wells Fargo Credit Agreement is held at variable interest rates. The Company has
cash flow exposure on its committed and uncommitted line of credit and long-term
debt due to its variable prime rate pricing. At December 31, 1999 and 1998, a 1%
change in the prime rate would not  materially  increase  or  decrease  interest
expense or cash flows.

ITEM 8.  FINANCIAL STATEMENTS AND SUPPLEMENTARY DATA.
         -------------------------------------------

                  Reference  is  made  to the  financial  statements,  financial
statement  schedules and notes thereto  included later in this report under Item
14.

ITEM 9.  CHANGES IN AND DISAGREEMENTS WITH ACCOUNTANTS
         ON ACCOUNTING AND FINANCIAL DISCLOSURE.

     Effective May 27, 1998, the Registrant  terminated Ernst & Young LLP as its
independent  accounting  firm. The termination of Ernst & Young LLP was approved
by the Audit Committee of the Board of Directors of the  Registrant.  There were
no  disagreements  with  Ernst & Young LLP during the last  fiscal  year  ending
December 31, 1997. Accordingly, Ernst & Young LLP has not advised the Registrant
of (i) the absence of the internal  controls  necessary  for the  Registrant  to
develop reliable  financial  statements,  (ii) any information which would cause
Ernst & Young LLP to no longer  rely on  management's  representations,  or that
Ernst & Young LLP was unwilling to be associated  with the financial  statements
prepared by management,  (iii) any need to expand significantly the scope of its
audit, or any information that if further investigated may (a) materially impact
the fairness or  reliability  of either a previously  issued audit report or the
underlying  financial  statements  or any  financial  statements  for any fiscal
period subsequent to the date of the most recent financial statements covered by
an  audit  report  or (b)  cause  it to be  unwilling  to rely  on  management's
representations or be associated with the Registrant's financial statements,  or
(iv) any information that has come to the attention of Ernst & Young LLP that it
concluded  materially  impacts  the  fairness  or  reliability  of either  (a) a
previously issued audit report or the underlying financial statements or (b) any
financial  statements  issued  or  to  be  issued  covering  any  fiscal  period
subsequent  to the date of the most recent  financial  statements  covered by an
audit report.

                  Effective  June 3, 1998,  the  Registrant  engaged  Deloitte &
Touche LLP as its independent  accounting firm. Neither the Registrant or any of
its subsidiaries has had any prior relationships with Deloitte & Touche LLP.

<PAGE>



                                    PART III

ITEM 10.          DIRECTORS AND EXECUTIVE OFFICERS OF THE REGISTRANT.

                  This  information  will be contained in the  Definitive  Proxy
                  Statement   with  respect  to  the  2000  Annual   Meeting  of
                  Stockholders of MEDTOX Scientific,  Inc., to be filed with the
                  Securities and Exchange  Commission  within 120 days following
                  the end of the fiscal year ended December 31, 1999.

ITEM 11.          EXECUTIVE COMPENSATION.

                  This  information  will be contained in the  Definitive  Proxy
                  Statement   with  respect  to  the  2000  Annual   Meeting  of
                  Stockholders of MEDTOX Scientific,  Inc., to be filed with the
                  Securities and Exchange  Commission  within 120 days following
                  the end of the fiscal year ended December 31, 1999.

ITEM 12.          SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND
                  MANAGEMENT.

                  This  information  will be contained in the  Definitive  Proxy
                  Statement   with  respect  to  the  2000  Annual   Meeting  of
                  Stockholders of MEDTOX Scientific,  Inc., to be filed with the
                  Securities and Exchange  Commission  within 120 days following
                  the end of the fiscal year ended December 31, 1999.

ITEM 13.          CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS.

                  This  information  will be contained in the  Definitive  Proxy
                  Statement   with  respect  to  the  2000  Annual   Meeting  of
                  Stockholders of MEDTOX Scientific,  Inc., to be filed with the
                  Securities and Exchange  Commission  within 120 days following
                  the end of the fiscal year ended December 31, 1999.


<PAGE>


                                     PART IV

ITEM 14 - EXHIBITS, FINANCIAL STATEMENT SCHEDULES, REPORTS ON FORM 8-K.
- ----------------------------------------------------------------------


a.       (i)      Financial Statements                                   Page
                  --------------------

                  Reports of Independent Auditors...................      35
                  Consolidated Balance Sheets at December
                    31, 1999 and 1998.................................    37
                  Consolidated Statements of Operations
                    for the years ended December 31,
                    1999, 1998 and 1997...............................    38
                  Consolidated Statements of Stockholders'
                    Equity for the years
                    ended December 31, 1999,
                    1998 and 1997.....................................    39
                  Consolidated Statements of Cash
                    Flows for the years ended
                    December 31, 1999, 1998 and 1997...........           40
                  Notes to Consolidated Financial
                    Statements.........................................   41

         (ii)     Consolidated Financial Statement Schedules

                  Schedule II - Valuation and

                    Qualifying Accounts ...............................   52

All other financial  statement  schedules normally required under Regulation S-X
are omitted as the required information is inapplicable.

         (iii)    Exhibits

     3.1 Bylaws of the  Registrant  (incorporated  by  reference  to Exhibit 4.2
filed with the  Registrant's  Report on Form 10-Q for the quarter ended December
31, 1986).

     3.2 Restated  Certificate of Incorporation of the Registrant filed with the
Delaware  Secretary  of State on July 29, 1994  (incorporated  by  reference  to
Exhibit 3.8 filed with the Registrant's Form 10-K for fiscal year ended December
31, 1994).

     3.3  Certificate  of  Amendment  of  Certificate  of  Incorporation  of the
Registrant, filed with the Delaware Secretary of State on November 27, 1995.

     3.4 Amended  Certificate  of  Designations  of  Preferred  Stock  (Series A
Convertible  Preferred  Stock)  of  the  Registrant,  filed  with  the  Delaware
Secretary of State on January 29, 1996 (incorporated by reference to Exhibit 3.1
filed with the Registrant's report on Form 8-K dated January 30, 1996.)
<PAGE>

          3.5 Certificate of Amendment of Certificate of Incorporation of MEDTOX
     Scientific,  Inc.  filed  with  Delaware  Secretary  of State on  September
     17,1998

     10.2 Registrant's Stock Option Plan (as amended and restated) (incorporated
by reference to Exhibit 10.2 filed with the Registrant's Report on Form 10-K for
the fiscal year ended December 30, 1990).

     10.3  Second  Amendment  dated  December  31,  1986  to  Exclusive  License
Agreement amending and restating  exclusive license granted by the Registrant to
Disease  Detection  International,  Inc.  (incorporated  by reference to Exhibit
10.25 filed with the  Registration  Statement on Form S-1 dated August 26, 1987,
Commission File No. 33-15543).

     10.5 Non-Qualified  Stock Option Agreement between the Registrant and James
D. Skinner dated as of July 1, 1987  (incorporated by reference to Exhibit 10.26
filed with the Registrant's  Registration Statement on Form S-1 dated August 26,
1987, Commission File No. 33-15543).

     10.6 Non-Qualified  Stock Option Agreement between the Registrant and James
D.  Skinner   (incorporated  by  reference  to  Exhibit  10.17  filed  with  the
Registrant's Form 10-K for the fiscal year ended December 31, 1988).

     10.7 Non-Qualified  Stock Option Agreement between the Registrant and James
D.  Skinner  dated as of August 10, 1988  (incorporated  by reference to Exhibit
10.18 filed with the  Registrant's  Form 10-K for the fiscal year ended December
31, 1987).

     10.8 Lease Agreement, dated as of June 1, 1989 between Samuel C. Powell, as
lessor, and EDITEK, as lessee relating to premises located at 1238 Anthony Road,
Burlington,  North  Carolina  (incorporated  by  reference  as  filed  with  the
Registrant's report on Form 10-Q for the quarter ended June 30, 1989).

     10.12 Stock Option  Agreement  dated May 4, 1990 between the Registrant and
Samuel C. Powell amending and restating the Non-Qualified Stock Option Agreement
between  the  Registrant  and  Samuel  C.  Powell  dated  as of  May  23,  1988.
(Incorporated  by reference to Exhibit  10.34 filed with the  Registrant's  Form
10-K for the fiscal year ended December 31, 1990).

     10.13 Loan Modification  Agreement dated May 3, 1990 between the Registrant
and James D. Skinner  regarding  the  Promissory  Note dated as of September 10,
1988 by James D.  Skinner  to the  Registrant.  (Incorporated  by  reference  to
Exhibit  10.36 filed with the  Registrant's  Form 10-K for the fiscal year ended
December 31, 1990).

     10.14  Stock  Purchase  Agreements  dated as of July 19,  1991  between the
Registrant and Walter O. Fredericks, Peter J. Heath, Samuel C. Powell, and James
D.  Skinner.   (Incorporated   by  reference  to  Exhibit  (a)  filed  with  the
Registrant's Form 10-Q for the quarter ended June 30, 1991).
<PAGE>

     10.15  Form of Stock  Purchase  Agreement  dated as of  September  3,  1992
between the  Registrant  and  Purchasers  of EDITEK's  common stock in a private
placement  on  September 3, 1992.  (Incorporated  by reference in Exhibit  10.46
filed with the  Registrant's  Form 10-K for the fiscal year ended  December  31,
1992).

     10.16 Agreement and Plan of Merger between the Registrant, PDLA Acquisition
Corporation,  and  Princeton  Diagnostic  Laboratories  of America,  Inc.  dated
October  12,  1993.  (Incorporated  by  reference  to Exhibit (a) filed with the
Registrant's Form 10-Q for the quarter ended December 31, 1993.)

     10.17 Registrant's  Amended and Restated Stock Option Plan for non-employee
directors  (incorporated  by reference to Exhibit 4 filed with the  Registrant's
Registration  Statement on Form S-8 dated February 21, 1995, Commission File No.
33-89646).

     10.18 Registrant's  Equity  Compensation Plan (incorporated by reference to
Exhibit 4 filed with the Registrant's  Registration  Statement on Form S-8 dated
November 11, 1993, Commission File No. 33-71490).

     10.19  Registrant's  Amended and Restated Qualified Employee Stock Purchase
Plan  (incorporated  by  reference  to  Exhibit  4 filed  with the  Registrant's
Registration  Statement on Form S-8 dated November 11, 1993, Commission File No.
33-71596).

     10.20  Non-Qualified  Stock Option Agreement between the Registrant an Mark
D. Dibner dated January 14, 1993 (incorporated by reference to Exhibit 4.2 filed
with the  Registrant's  Registration  Statement  on Form S-8 dated  February 21,
1995, Commission File No. 33-89646).

     10.22  Asset  Purchase  Agreement  dated  as of July 1,  1995  between  the
Registrant and MEDTOX Laboratories,  Inc.  (incorporated by reference to Exhibit
10.1 filed with the Registrant's Report on Form 8-K dated January 30, 1996).

     10.23  Amendment  Agreement  dated  as  of  January  2,  1996  between  the
Registrant and MEDTOX Laboratories,  Inc.  (incorporated by reference to Exhibit
10.2 filed with the Registrant's Report on Form 8-K dated January 30, 1996).

     10.24  Assignment  Agreement dated as of January 10, 1996 between and among
the  Registrant,   MEDTOX   Laboratories,   Inc.  and   Psychiatric   Diagnostic
Laboratories of America,  Inc.  (incorporated by reference to Exhibit 10.3 filed
with the Registrant's Report on Form 8-K dated January 30, 1996).

     10.25  Amendment   Agreement  dated  as  of  January  30,  1996  among  the
Registrant, MEDTOX Laboratories, Inc. and Psychiatric Diagnostic Laboratories of
America,  Inc.  (incorporated  by  reference  to  Exhibit  10.25  filed with the
Registrant's Report on Form 10-K for the fiscal year ended December 31, 1996.)
<PAGE>

     10.26 Loan and Security Agreement (together with the Exhibits and Schedules
thereto) by and between the Registrant,  Psychiatric Diagnostic  Laboratories of
America,  Inc.,  diAGnostix,  inc. and Heller Financial,  Inc. dated January 30,
1996  (incorporated  by reference  to Exhibit  10.4 filed with the  Registrant's
Report on form 8-K dated January 30, 1996).

     10.27  Term  Note A  executed  by the  Registrant,  Psychiatric  Diagnostic
Laboratories of America, Inc. and diAGnostix in favor of Heller Financial,  Inc.
dated January 30, 1996 (incorporated by reference to Exhibit 10.5 filed with the
Registrant's Report on Form 8-K dated January 30, 1996).

     10.28  Term  Note B  executed  by the  Registrant,  Psychiatric  Diagnostic
Laboratories of America, Inc. and diAGnostix in favor of Heller Financial, Inc.,
dated January 30, 1996 (incorporated by reference to Exhibit 10.6 filed with the
Registrant's Report on Form 8-K dated January 30, 1996).

     10.29 Assignment for Security (Patents) executed by the Registrant in favor
of Heller Financial,  Inc., dated January 30, 1996 (incorporated by reference to
Exhibit 10.7 filed with the  Registrant's  Report on Form 8-K dated  January 30,
1996).

     10.30  Assignment  for  Security  -  EDITEK  (Trademarks)  executed  by the
Registrant  in  favor  of  Heller  Financial,   Inc.,  dated  January  30,  1996
(incorporated by reference to Exhibit 10.8 filed with the Registrant's Report on
Form 8-K dated January 30, 1996).

     10.31  Assignment  for  Security  -  Princeton   (Trademarks)  executed  by
Princeton Diagnostic Laboratories of America, Inc. in favor of Heller Financial,
Inc.,  dated January 30, 1996  (incorporated  by reference to Exhibit 10.9 filed
with the Registrant's Report on Form 8-K dated January 30, 1996).

     10.32 Lease Agreement  between MEDTOX  Laboratories,  Inc. and Phoenix Home
Life Mutual Ins. Co. dated April 1, 1992, and amendments  thereto  (incorporated
by reference  to Exhibit  10.10 filed with the  Registrant's  Report on Form 8-K
dated January 30, 1996).

     10.33 Employment  Agreement between the Registrant and Harry G. McCoy dated
January 30, 1996.  (Incorporated  by  reference to Exhibit  10.33 filed with the
Registrant's Report on Form 10-K for the fiscal year ended December 31, 1995.)

     10.34   Registrant's   Amended  and  Restated  Equity   Compensation   Plan
(increasing  shares to 3,000,000).  (Incorporated  by reference to Exhibit 10.34
filed  with the  Registrant's  Report on Form  10-K for the  fiscal  year  ended
December 31, 1995.)

     10.35  Asset  Purchase  Agreement  dated  as of May 31,  1995  between  the
Registrant, Bioman Products, Inc. and NOVAMANN International, Inc. (Incorporated
by reference to Exhibit  10.35 filed with the  Registrant's  Report on Form 10-K
for the fiscal year ended December 31, 1995.)
<PAGE>

     10.36  Securities  Purchase  Agreement  dated  January 31, 1996 between the
Registrant and Harry G. McCoy. (Incorporated by reference to Exhibit 10.36 filed
with the Registrant's Report on Form 10-K for the fiscal year ended December 31,
1995.)

     10.37  Registration  Rights  Agreement  dated  February 1, 1996 between the
Registrant and Harry G. McCoy. (Incorporated by reference to Exhibit 10.37 filed
with the Registrant's Report on Form 10-K for the fiscal year ended December 31,
1995.)

     10.38 Agreement  regarding  rights to "MEDTOX" name dated as of January 30,
1996 between the  Registrant and Harry G. McCoy.  (Incorporated  by reference to
Exhibit  10.38  filed with the  Registrant's  Report on Form 10-K for the fiscal
year ended December 31, 1995.)

     10.39  Warrant  Agreement  dated as of December 18, 1995 between  Samuel C.
Powell and the  Registrant.  (Incorporated  by reference to Exhibit  10.39 filed
with the Registrant's Report on Form 10-K for the fiscal year ended December 31,
1995.)

     10.40 Termination and Settlement Agreement dated as of July 3, 1996 between
the Registrant and James D. Skinner. (Incorporated by reference to Exhibit 10.40
filed  with the  Registrant's  Report on Form  10-K for the  fiscal  year  ended
December 31, 1996.)

     10.41 Agreement dated as of March 17, 1997 between the Registrant and Harry
G. McCoy  whereby  Dr.  McCoy  assigns  his rights to the name  "MEDTOX"  to the
Registrant.   (Incorporated  by  reference  to  Exhibit  10.41  filed  with  the
Registrant's Report on Form 10-K for the fiscal year ended December 31, 1996.)

     10.42 Employment Agreement dated January 1, 1997 between the Registrant and
Harry G.  McCoy.  (Incorporated  by  reference  to Exhibit  10.42 filed with the
Registrant's Report on form 10-K for the fiscal year ended December 31, 1997.)

     10.43 Employment Agreement dated January 1, 1997 between the Registrant and
Richard J. Braun.  (Incorporated  by reference  to Exhibit  10.43 filed with the
Registrant's Report on form 10-K for the fiscal year ended December 31, 1997.)

b. Reports on Form 8-K

         None

<PAGE>



                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549
                             MEDTOX SCIENTIFIC, INC.
                               Report on Form 10-K

                        For year ended December 31, 1999

                INDEX TO EXHIBITS FILED SEPARATELY WITH FORM 10-K

EXHIBIT #        DESCRIPTION OF EXHIBIT

  3.6              Certificate of Amendment of Certificate of Incorporation
                   of MEDTOX Scientific, Inc. filed with Delaware Secretary of
                   State on November 19, 1999.

  4.1              Form  of  12%   Subordinated   Notes  issued  by  the
                   Registrant through the first quarter of 1999 to raise
                   an aggregate amount of $575,000 in subordinate  debt,
                   all with a maturity date of December 31, 2001.

  4.2              Form of Warrant accompanying the 12% Subordinated Notes
                   issued through the first quarter of 1999.

  10.44            Employment Agreement dated January 1, 2000 between the
                   Registrant and Richard J. Braun.

  10.45            Employment Agreement dated January 1, 2000 between the
                   Registrant and Harry G. McCoy.

  24.1             Consent of Deloitte & Touche LLP

  24.2             Consent of Ernst & Young LLP

  27               Financial Data Schedule


<PAGE>




                                   SIGNATURES

                  Pursuant  to the  requirements  of  Section 13 or 15(d) of the
Securities  Act of 1934, the Registrant has duly caused this Annual Report to be
signed on its behalf by the  undersigned,  thereunto duly authorized on the 28th
of March 2000.

                                   MEDTOX Scientific, Inc.
                                   Registrant

                                   By:/s/ Harry G. McCoy, Pharm.D.
                                   ----------------------------
                                   Harry G. McCoy, Pharm.D.
                                   President and
                                   Chairman of the Board

                  Pursuant to the  requirements  of the  Securities Act of 1934,
this  Registration  Statement has been signed below by the following  persons on
behalf of the Registrant in the capacities and on the dates indicated.

         Signature                   Title                            Date

/s/ Harry G. McCoy, Pharm.D.        President,                   March 28, 2000
Harry G. McCoy                      and Chairman of the Board

/s/ Richard J. Braun                Chief Executive Officer      March 28, 2000
Richard J. Braun                    Director

/s/ James B. Lockhart               Vice President,              March 28, 2000
James B. Lockhart                   Chief Financial Officer and
                                    Secretary

/s/ Samuel C. Powell                Director                     March 28, 2000
Samuel C. Powell, Ph.D.


/s/ Miles E. Efron                  Director                     March 28, 2000
Miles E. Efron


<PAGE>



INDEPENDENT AUDITORS' REPORT

To the Stockholders and Board of Directors
MEDTOX Scientific, Inc.

We  have  audited  the  accompanying   consolidated  balance  sheets  of  MEDTOX
Scientific,  Inc. (the Company) as of December 31, 1999 and 1998 and the related
consolidated statements of operations,  stockholders' equity, and cash flows for
the years then ended. Our audits also included the financial  statement schedule
listed in the index as Item 14.a.(ii).  These consolidated  financial statements
and the financial  statement  schedule are the  responsibility  of the Company's
management.  Our  responsibility  is to express  an  opinion on these  financial
statements based on our audits.

We conducted our audits in accordance with auditing standards generally accepted
in the  United  States of  America.  Those  standards  require  that we plan and
perform the audit to obtain  reasonable  assurance  about  whether the financial
statements are free of material misstatement.  An audit includes examining, on a
test basis,  evidence  supporting  the amounts and  disclosures in the financial
statements.  An audit also includes assessing the accounting principles used and
significant  estimates  made by  management,  as well as evaluating  the overall
financial  statement  presentation.  We believe our audits  provide a reasonable
basis for our opinion.

In our opinion,  such consolidated  financial  statements present fairly, in all
material  respects,  the  financial  position of MEDTOX  Scientific,  Inc. as of
December 31, 1999 and 1998 and the results of its  operations and its cash flows
for the years then ended,  in conformity with  accounting  principles  generally
accepted in the United States of America.  Also, in our opinion,  such financial
statement  schedule,  when  considered  in  relation  to the basic  consolidated
financial statements taken as a whole,  presents fairly in all material respects
the information set forth therein.


/s/ Deloitte & Touche LLP


Minneapolis, Minnesota
February 18, 2000


<PAGE>

                         Report of Independent Auditors


Board of Directors and Shareholders
Medtox Scientific, Inc. (formerly EDITEK, Inc.)

We  have  audited  the  accompanying   consolidated  statements  of  operations,
stockholders'  equity  and cash flows for the year ended  December  31,  1997 of
Medtox  Scientific,  Inc.  (formerly EDITEK,  Inc.). Our audit also included the
financial   statement  schedule  listed  in  the  Index  at  Item  14(a).  These
consolidated  financial  statements and schedule are the  responsibility  of the
Company's  management.  Our  responsibility  is to  express  an opinion on these
consolidated financial statements and schedule based on our audit.

We conducted our audit in accordance with generally accepted auditing standards.
Those standards  require that we plan and perform the audit to obtain reasonable
assurance   about  whether  the  financial   statements  are  free  of  material
misstatement.  An audit includes examining, on a test basis, evidence supporting
the amounts and disclosures in the financial statements.  An audit also includes
assessing the  accounting  principles  used and  significant  estimates  made by
management,  as well as evaluating the overall financial statement presentation.
We believe that our audit provides a reasonable basis for our opinion.

In our opinion,  the financial  statements  referred to above present fairly, in
all material respects,  the consolidated  results of its operations and its cash
flows for the year ended December 31, 1997 of Medtox Scientific,  Inc. (formerly
EDITEK,  Inc.), in conformity  with generally  accepted  accounting  principles.
Also, in our opinion, the related financial statement schedule,  when considered
in relation to the consolidated  financial statements taken as a whole, presents
fairly in all material respects the information set forth therein.


                                                          /s/ Ernst & Young LLP


Minneapolis, Minnesota
February 18, 2000








<PAGE>


MEDTOX SCIENTIFIC, INC.

CONSOLIDATED BALANCE SHEETS
DECEMBER 31, 1999 AND 1998

(In thousands, except for number of shares)
<TABLE>
<CAPTION>

                                                                                                1999       1998
<S>                                                                                        <C>          <C>
ASSETS

CURRENT ASSETS:
   Cash and cash equivalents                                                                  $     576
   Accounts receivable:
     Trade, less allowance for doubtful accounts ($274 in 1999 and $245 in 1998)                  6,982  $   5,957
     Other                                                                                          125         30
                                                                                              ---------  ---------
                                                                                                  7,683      5,987
   Inventories:
     Raw materials                                                                                  462        444
     Work in process                                                                                230        151
     Finished goods                                                                                 126         80
     Supplies                                                                                       734        432
                                                                                              ---------  ---------
                                                                                                  1,552      1,107
   Prepaid expenses and other                                                                     1,059        524
                                                                                              ---------  ---------
           Total current assets                                                                  10,294      7,618

EQUIPMENT AND IMPROVEMENTS:
   Furniture and equipment                                                                       12,820     11,779
   Leasehold improvements                                                                         1,354      1,283
                                                                                              ---------  ---------
                                                                                                 14,174     13,062
   Less accumulated depreciation and amortization                                               (11,358)   (10,087)
                                                                                              ---------  ---------
                                                                                                  2,816      2,975
GOODWILL, net of accumulated amortization of $3,568 in 1999 and $2,697 in 1998                   13,161     14,007
                                                                                              ---------  ---------
                                                                                              $  26,271  $  24,600

LIABILITIES AND STOCKHOLDERS' EQUITY

CURRENT LIABILITIES:
   Checks written in excess of bank balances                                                             $     142
   Line of credit                                                                             $   4,208      3,095
   Accounts payable                                                                               3,682      3,531
   Accrued expenses                                                                               1,554      1,724
   Current portion of restructuring accrual                                                         384      1,079
   Current portion of long-term debt                                                              1,236      1,140
   Current portion of capital leases                                                                186        186
                                                                                              ---------  ---------
           Total current liabilities                                                             11,250     10,897

LONG-TERM PORTION OF RESTRUCTURING ACCRUAL                                                           85         76

LONG-TERM DEBT                                                                                    1,737      1,785

LONG-TERM PORTION OF CAPITAL LEASES                                                                 409        516

COMMITMENTS AND CONTINGENCIES

STOCKHOLDERS' EQUITY:
   Preferred stock, $1.00 par value; authorized shares, 1,000,000; none
     issued and outstanding
   Common stock, $0.15 par value; authorized shares, 7,400,000; issued
     and outstanding shares, 2,904,410 in 1999 and 2,899,669 in 1998                                436        435
   Additional paid-in capital                                                                    59,859     59,815
   Accumulated deficit                                                                          (47,329)   (48,748)
   Treasury stock                                                                                  (176)      (176)
                                                                                              ---------  ---------
           Total stockholders' equity                                                            12,790     11,326
                                                                                              ---------  ---------
                                                                                              $  26,271  $  24,600
</TABLE>

See notes to consolidated financial statements.

<PAGE>


MEDTOX SCIENTIFIC, INC.

CONSOLIDATED  STATEMENTS OF operations  YEARS ENDED december 31, 1999, 1998, AND
1997 (In thousands, except share and per share data)
<TABLE>
<CAPTION>

                                                                          1999             1998           1997
<S>                                                                <C>              <C>              <C>
REVENUES:

   Laboratory service revenues                                        $     31,012    $     27,070     $     25,899
   Product sales                                                             3,991           2,505            2,695
   Interest and other income                                                                     1                6
                                                                      ------------    ------------     ------------
                                                                            35,003          29,576           28,600
COSTS AND EXPENSES:
   Cost of services                                                         20,572          18,689           16,191
   Cost of sales                                                             2,177           1,671            1,697
   Selling, general, and administrative                                      9,348           8,974            9,510
   Research and development                                                    834           1,153              965
   Interest and financing costs                                                817             674              609
   Restructuring costs                                                        (164)            712             (397)
                                                                      ------------    ------------     ------------
                                                                            33,584          31,873           28,575
                                                                      ------------    ------------     ------------

NET INCOME (LOSS)                                                     $      1,419    $     (2,297)    $         25
                                                                      ============    ============     ============

BASIC EARNINGS (LOSS) PER COMMON SHARE                                $       0.49    $     (0.79)     $       0.01
                                                                      ============    ===========      ============

WEIGHTED AVERAGE NUMBER OF BASIC COMMON
   SHARES OUTSTANDING                                                    2,902,087       2,893,399        2,566,966
                                                                       ===========     ===========      ===========

DILUTED EARNINGS (LOSS) PER COMMON SHARE                              $       0.48    $     (0.79)     $       0.01
                                                                      ============    ===========      ============

WEIGHTED AVERAGE NUMBER OF DILUTED
   COMMON SHARES OUTSTANDING                                             2,985,107       2,893,399        2,566,966
                                                                      ============    ============     ============

</TABLE>

See notes to consolidated financial statements.

<PAGE>


MEDTOX SCIENTIFIC, INC.

CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY
(In thousands, except for number of shares)
<TABLE>
<CAPTION>

                                Preferred Stock         Common Stock      Additional
                                            Par                   Par      Paid-in  Accumulated Treasury
                                  Shares   Value     Shares      Value     Capital    Deficit     Stock     Total
<S>                          <C>         <C>      <C>         <C>       <C>        <C>        <C>        <C>
BALANCE AT DECEMBER 31, 1996        238             1,277,790   $   192   $ 60,008   $(46,476)  $   (176)  $ 13,548

   Stock issued for MEDTOX
     Laboratories, Inc. acquisition                   417,292        62        (62)
   Sale of common stock                                10,524         2         73                               75
   Conversion of preferred stock
     to common stock               (234)            1,135,803       170       (247)                             (77)
   Net income                                                                              25                    25
                                   ----             ---------   -------   --------   --------   --------   --------

BALANCE AT DECEMBER 31, 1997          4             2,841,409       426     59,772    (46,451)      (176)    13,571

   Sale of common stock                                 4,927         1         24                               25
   Conversion of preferred stock to
     common stock                    (4)               53,333         8         (8)
   Value of warrants issued                                                     27                               27
   Net loss                                                                            (2,297)               (2,297)
                                   ----             ---------   -------   --------   --------   --------   --------

BALANCE AT DECEMBER 31, 1998                        2,899,669       435     59,815    (48,748)      (176)    11,326

   Sale of common stock                                 2,241                    6                                6
   Stock issued for settlement                          2,500         1          9                               10
   Value of warrants issued                                                     29                               29
   Net income                                                                           1,419                 1,419
                                   ----   ------    ---------   -------   --------   --------   --------   --------

BALANCE AT DECEMBER 31, 1999         -    $   -     2,904,410   $   436   $ 59,859   $(47,329)  $   (176)  $ 12,790
                                   ====   ======    =========   =======   ========   ========   ========   ========

</TABLE>

See notes to consolidated financial statements.

<PAGE>


MEDTOX SCIENTIFIC, INC.

CONSOLIDATED STATEMENTS OF CASH FLOWS
YEARS ENDED DECEMBER 31, 1999, 1998, AND 1997

(In thousands)
<TABLE>
<CAPTION>

                                                                                   1999         1998       1997
<S>                                                                          <C>          <C>          <C>
CASH FLOWS FROM OPERATING ACTIVITIES:
   Net income (loss)                                                            $  1,419     $ (2,297)    $      25
   Adjustments to reconcile net income (loss) to net cash
       provided by (used in) operating activities:
     Depreciation and amortization                                                 2,124        2,094         2,083
     Provision for losses on accounts receivable                                      29           42           156
     Gain on sale of equipment                                                                     (4)
     Changes in operating assets and liabilities:
       Accounts receivable                                                        (1,148)        (476)       (1,156)
       Inventories                                                                  (445)          35           148
       Prepaid expenses and other                                                   (535)        (109)         (275)
       Accounts payable and accrued expenses                                         (19)         161           627
       Restructuring accruals                                                       (687)         369        (1,017)
                                                                                --------     --------     ---------
           Net cash provided by (used in) operating activities                       738         (185)          591

CASH FLOWS FROM INVESTING ACTIVITIES:
   Purchase of equipment and improvements                                         (1,119)        (949)       (1,315)
   Proceeds from sale of equipment                                                                  4
                                                                                --------     --------       --------
           Net cash used in investing activities                                  (1,119)        (945)       (1,315)

CASH FLOWS FROM FINANCING ACTIVITIES:
   (Decrease) increase in checks in excess of bank balances                         (142)         142
   Net proceeds from sale of common stock                                              6           25            (2)
   Proceeds from line of credit and long-term debt                                39,211       36,669         2,135
   Principal payments on line of credit and long-term debt                       (38,049)     (35,646)       (1,346)
   Principal payments on capital leases                                             (107)        (118)          (87)
   Other                                                                              38
                                                                                --------      -------        -------
           Net cash provided by financing activities                                 957        1,072           700
                                                                                --------     --------     ---------

INCREASE (DECREASE) IN CASH AND CASH EQUIVALENTS                                     576          (58)          (24)

CASH AND CASH EQUIVALENTS AT BEGINNING OF YEAR                                       -             58            82
                                                                                --------     --------     ---------

CASH AND CASH EQUIVALENTS AT END OF YEAR                                        $    576     $     -      $      58
                                                                                ========     ========     =========

</TABLE>

SUPPLEMENTAL NONCASH ACTIVITIES:

During 1999 and 1998, the Company entered into capital lease agreements totaling
$101,000 and $414,000, respectively.


See notes to consolidated financial statements.

<PAGE>


MEDTOX SCIENTIFIC, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
YEARS ENDED DECEMBER 31, 1999 AND 1998

1.      Summary of significant accounting policies

        The Company - The consolidated financial statements include the accounts
        of MEDTOX  Scientific,  Inc. and its wholly owned  subsidiaries,  MEDTOX
        Laboratories,  Inc. (MEDTOX  Laboratories) and MEDTOX Diagnostics,  Inc.
        (MEDTOX Diagnostics) (collectively referred to as the Company).

        MEDTOX Laboratories provides laboratory analyses,  logistics management,
        data management,  and program management  services.  Laboratory analyses
        including  clinical  testing services for the detection of substances of
        abuse and other  toxins in  biological  fluids and  tissues.  Logistics,
        data,  and program  management  services  include  courier  services for
        medical specimen  transportation,  management  programs for on-site drug
        testing,  data  collection  and  reporting  services,   coordination  of
        specimen collection sites, and medical surveillance program management.

        MEDTOX Diagnostics is engaged in the research,  development, and sale of
        products based upon enzyme  immunoassay  technology for the detection of
        antibiotic  residues,  mycotoxins,  drugs of abuse and  other  hazardous
        substances as well as  distribution  of  agridiagnostic  and food safety
        testing products.

        All  significant  intercompany  transactions  and  balances  have been
        eliminated.

        Cash Equivalents - Cash equivalents  include highly liquid investments
        maturing within three months of purchase.

        Trade  Accounts  Receivable  - Sales  are  made to  local  and  national
        customers  including  corporations,  clinical  laboratories,  government
        agencies,  medical  professionals,  law enforcement agencies, and health
        care  facilities.  Concentration  of credit  risk is limited  due to the
        large number of  customers  to which the Company  sells its products and
        services.  The Company  extends  credit  based on an  evaluation  of the
        customer's financial condition, and receivables are generally unsecured.
        The Company  provides an allowance  for doubtful  accounts  equal to the
        estimated  losses  expected to be incurred in the collection of accounts
        receivable.

        Inventories - Inventories  are valued at the lower of cost  (first-in,
        first-out method) or market.

        Equipment and  Improvements - Equipment and  improvements  are stated at
        cost.   Provisions  for  depreciation   have  been  computed  using  the
        straight-line  method to amortize  the cost of  depreciable  assets over
        their estimated useful lives.  Leasehold improvements are amortized over
        the  lesser  of the  lease  term or the  economic  useful  lives  of the
        improvements.
<PAGE>

        Revenue  Recognition  -  Sales  are  recognized  in the  statement  of
        operations when products are shipped or services are rendered.

        Research and Development - Research and development  expenditures  are
        charged to expense as incurred.

        Income Taxes - The Company uses the liability  method of accounting  for
        income taxes. Under this method, deferred tax assets and liabilities are
        determined based on differences  between the financial reporting and tax
        bases of assets and  liabilities  and are measured using the enacted tax
        rates and laws that will be in effect when the  differences are expected
        to reverse.

        Earnings  (Loss) per Share - Earnings  (loss) per share of common  stock
        amounts  are based on the  weighted  average  number of shares of common
        stock  outstanding,  as well as shares of common  stock  that would have
        been issued and outstanding in certain  transactions had the Company had
        the  necessary  number of authorized  shares of common stock.  All other
        common stock  equivalents  were  anti-dilutive  and  therefore  were not
        included in the computation of earnings (loss) per share for all periods
        presented.

        Goodwill - Goodwill is amortized on a straight-line basis over 20 years.
        The   carrying   value  of   goodwill  is  reviewed  if  the  facts  and
        circumstances  suggest that it may be impaired. If this review indicates
        that  goodwill  will  not be  recoverable,  as  determined  based on the
        undiscounted  cash  flows of the  entity  acquired  over  the  remaining
        amortization  period,  the Company's  carrying  value of the goodwill is
        reduced by the estimated shortfall of cash flows. Based on the Company's
        analysis of future cash flows,  the carrying value of goodwill  appeared
        recoverable as of December 31, 1999 and 1998.

        Impairment of Long-Lived Assets - The Company periodically evaluates the
        carrying  value of  long-lived  assets  for  potential  impairment.  The
        Company  considers  projected  future  operating  results,  cash  flows,
        trends,   and  other   circumstances   in  making  such   estimates  and
        evaluations. When the carrying value of any long-lived asset exceeds its
        projected undiscounted cash flows, an impairment is recognized to reduce
        the carrying value to its fair market value.

        Use  of  Estimates  - The  preparation  of  the  consolidated  financial
        statements in conformity with generally accepted  accounting  principles
        requires  management to make estimates and  assumptions  that affect the
        amounts   reported  in  the   consolidated   financial   statements  and
        accompanying notes. Actual results could differ from those estimates.

        Reclassifications - Certain reclassifications have been made to the 1998
        and 1997  consolidated  financial  statements  to conform  with the 1999
        presentation. These reclassifications had no effect on net income (loss)
        or total stockholders' equity as previously reported.

        Stock-Based  Compensation - Statement of Financial  Accounting Standards
        (SFAS)  No.  123,  Accounting  for  Stock-Based  Compensation,  requires
        companies to measure employee stock compensation plans based on the fair
        value  method  of  accounting.   However,   the  statement   allows  the
        alternative  of continued  use of  Accounting  Principles  Board Opinion
        (APBO) No. 25, Accounting for Stock Issued to Employees,  with pro forma
        disclosure  of net income and  earnings per share  determined  as if the

<PAGE>

        fair value method had been applied in measuring  compensation  cost. The
        Company elected the continued use of APBO No. 25.

        Comprehensive  Earnings  -  Comprehensive  earnings  is a measure of all
        nonowner changes in shareholders'  equity and includes such items as net
        earnings,  certain foreign currency  translation items,  minimum pension
        liability  adjustments,  and changes in the value of  available-for-sale
        securities.  In 1999,  1998,  and 1997,  comprehensive  earnings for the
        Company were equivalent to net earnings as reported.

        Derivative Instruments and Hedging Activities - SFAS No. 133, Accounting
        for Derivative  Instruments and Hedging  Activities,  was issued in June
        1998 and establishes  accounting and reporting  standards for derivative
        instruments.  The statement  requires  recognition of all derivatives as
        either  assets or  liabilities  in the  statement of financial  position
        measured at fair value and will be  effective  in fiscal year 2001.  The
        Company has not yet  completed  its  analysis of the impact SFAS No. 133
        will have on its consolidated financial statements.

2.      SEGMENTS

        The Company has two reportable segments: Lab Services and Product Sales.
        The Lab  Services  segment  consists  of MEDTOX  Laboratories.  Services
        provided include forensic toxicology,  clinical toxicology, heavy metals
        analyses, courier delivery, and medical surveillance.  The Product Sales
        segment consist of MEDTOX  Diagnostics.  Products  manufactured  include
        easy to use,  inexpensive,  on-site  drug  tests  such  as  PROFILE  II,
        EX-SCREEN, EX-QUANT, and VERDICT II.

        In evaluating financial performance, management focuses on net income as
        a segment's  measure of profit or loss. The  accounting  policies of the
        segments are the same as those  described in the summary of  significant
        accounting policies (see Note 1).
<TABLE>
<CAPTION>

        Segment Information
           (In thousands)                                        Lab Services          Product Sales       Total
      <S>                                                   <C>                    <C>              <C>

        1999:

          Net revenues                                          $    31,012            $    3,991       $    35,003
          Segment income (loss)                                       1,440                   (21)            1,419
          Segment assets                                             24,269                 2,002            26,271

        1998:

          Net revenues                                               27,070                 2,505            29,575
          Segment loss                                               (1,391)                 (906)           (2,297)
          Segment assets                                             23,289                 1,311            24,600

        1997:

          Net revenues                                               25,899                 2,695            28,594
          Segment income (loss)                                         430                  (405)               25
          Segment assets                                             23,469                 1,412            24,881

</TABLE>

<PAGE>


3.      DEBT

        Long-term debt consisted of the following at December 31:
<TABLE>
<CAPTION>

                                                                                           1999             1998
      <S>                                                                            <C>             <C>

        Term loan, due November 2001, 9.75% at December 31, 1999                        $   1,358        $  2,066
        Overadvance term loan, due June 2000, 11.50% at December 31, 1999                     350              358
        Capex note, due November 2001, 9.75% at December 31, 1999                             649              347
        Subordinated notes, due December 2001, 12% at December 31, 1999                       537              148
        Note payable to bank, paid in 1999                                                                       6
        Various vehicle loans, due from October 2002 through
         December 2002, 2.90% to 7.49%                                                         79
                                                                                        ---------        ---------
                                                                                            2,973            2,925
        Less current portion                                                                1,236            1,140
                                                                                        ---------        ---------
                                                                                        $   1,737        $   1,785
                                                                                        =========        =========

        Long-term debt maturities at December 31, 1999 were as follows:

         2000                                                                                            $   1,236
         2001                                                                                                1,711
         2002                                                                                                   26
                                                                                                         ---------
                                                                                                         $   2,973
</TABLE>

        On  January  14,  1998,  the  Company  entered  into a  Credit  Security
        Agreement (the Wells Fargo Credit  Agreement)  with Wells Fargo Business
        Credit  (Wells  Fargo).  The Wells Fargo Credit  Agreement,  as amended,
        consists of (i) a term loan of  $2,125,000  bearing  interest at prime +
        1.25%;  (ii) an overadvance  term loan of $700,000  bearing  interest at
        prime + 3%; (iii) a revolving line of credit of not more than $6,000,000
        or 80% of the  Company's  eligible  trade  accounts  receivable  bearing
        interest  at prime + 1%; and (iv) a capex note of up to  $1,200,000  for
        the purchase of capital  equipment bearing interest at prime + 1.25%. At
        December 31, 1999,  $4,208,000 was outstanding  under the revolving line
        of  credit,  and  $1,020,000  was  available  to be  advanced  under the
        borrowing base formula.  The Wells Fargo Credit  Agreement is secured by
        virtually  all of the Company's  assets,  including  equipment,  general
        intangibles, inventories, and receivables.

        The Wells Fargo  Credit  Agreement  requires  the Company to comply with
        certain covenants and maintain certain quarterly  financial ratios as to
        minimum  debt service  coverage  and maximum debt to book net worth.  It
        also sets minimum  quarterly  net income and book net worth levels which
        restrict the payment of dividends.  As of December 31, 1999, the Company
        was in compliance with the provisions of the financial  covenants of the
        Wells Fargo Credit Agreement.

        On  December  31,  1998,  the Company  received  $175,000  from  private
        placements  of  subordinated  debt.  The notes  require  payment  of the
        principal amount on December 31, 2001. Interest at 12% per annum is paid
        semiannually on June 30 and December 31. In connection with the issuance
        of the  subordinated  notes,  the Company issued  warrants to purchase a
        number of shares of common stock equivalent to 25% of the face amount of
        the subordinated notes divided by the exercise price of $5.00 per share.

<PAGE>

        The  warrants  are  exercisable  from  December 15, 1999 to December 31,
        2001. In February 1999, the warrant  agreements were amended to decrease
        the exercise  price to $3.25 per share.  The Company has  determined the
        value of the  warrants at the date of grant to be $27,000.  The value of
        the warrants has been  accounted for as additional  paid-in  capital and
        deducted  from the  principal of the  subordinated  notes as discount on
        debt issued.

        During the first  quarter of 1999,  the Company  received an  additional
        $400,000  from private  placements of  subordinated  debt under the same
        terms as the December 1998 debt  issuances.  The Company has  determined
        the value of the warrants at the date of grant to be $29,000.  The value
        of the warrants has been  accounted  for as additional  paid-in  capital
        deducted  from the  principal of the  subordinated  notes as discount on
        debt issued.

        Interest  paid for all  outstanding  debt was  $784,000,  $599,000,  and
        $576,000  for the  years  ended  December  31,  1999,  1998,  and  1997,
        respectively.

4.      STOCKHOLDERS' EQUITY

        The Board of Directors  declared a  one-for-twenty  reverse  stock split
        effective  February 20, 1999.  Accordingly,  all stock option,  warrant,
        share,  and  per  share  data  included  in the  consolidated  financial
        statements have been restated to reflect the reverse split.

        As part of the purchase price paid by the Company for the acquisition of
        MEDTOX  Laboratories  in January 1996, the Company issued 125,865 shares
        of common stock.  In connection  with the issuance of the common shares,
        the  Company  agreed  that if,  after  the  closing  date of the  MEDTOX
        Laboratories acquisition, the market value of the Company's common stock
        declined below  approximately  $39.60 per share, the Company would issue
        additional shares of common stock (Additional Shares) to shareholders of
        MEDTOX Laboratories who retain their shares of common stock at specified
        dates through November 19, 1997 (the Repricing Dates).  The following is
        a summary  of the price  resets,  the  market  price per share  used for
        purposes of calculating  the reset quantity of shares,  and the quantity
        of additional shares that were issued in 1997:
<TABLE>
<CAPTION>

                                                                      Market Price Related             Shares
         Repricing Date                                                 to Repricing Date              Issued
     <S>                                                                <C>                          <C>
        May 23, 1996                                                         $31.20                       55,953
        November 22, 1996                                                    $19.00                       64,673
        March 27, 1997                                                        $8.25                      257,898
        November 19, 1997                                                     $7.50                       38,768
                                                                                                     -----------
                                                                                                         417,292
                                                                                                     ===========
</TABLE>

        At  December  31,  1999,  shares of common  stock  reserved  for  future
        issuance  upon  exercise of  outstanding  common  stock  warrants are as
        follows:

<PAGE>

<TABLE>
<CAPTION>

                                                                                                        Number of
                                            Exercise Price                   Period                      Shares
                                               Per Share                   Exercisable                  Reserved
    <S>                                     <C>                     <C>                              <C>
        Subordinated notes 12%                 $   3.25               December 15, 1999 to
                                                                        December 31, 2001                 44,230

</TABLE>
        In addition,  at December 31, 1999,  417,054 shares of common stock were
        reserved for future  issuances under the stock option plans discussed in
        Note 5.

        On September 18, 1998, the Company's  Board of Directors  authorized and
        declared a  dividend  of one  preferred  share  purchase  right for each
        common  share  then  outstanding.  Subsequent  to that date the  Company
        maintains a plan in which one  preferred  share  purchase  right (Right)
        exists for each common  share of the  Company.  Each Right  entitles its
        holder  to  purchase  one  one-hundredth  of a share of a new  series of
        junior  participating  preferred  stock at an exercise  price of $29.80,
        subject to adjustment.  The Rights are  exercisable  only if a person or
        group  acquires  beneficial  ownership  of 20  percent  or  more  of the
        Company's outstanding common stock.

5.      STOCK OPTION AND PURCHASE PLANS

        The Company has stock  option  plans to provide  incentives  to eligible
        employees,  officers,  and  directors  in the  form of  incentive  stock
        options,   nonqualified  stock  options,   stock  appreciation   rights,
        restricted and unrestricted stock awards,  performance shares, and other
        stock-based awards. The Compensation Committee of the Board of Directors
        determines the exercise price (not to be less than the fair market value
        of the underlying stock) at the date of grant.  Options generally become
        exercisable  in  installments  over a period  of one to five  years  and
        expire ten years from the date of grant.

        The  following  table  summarizes   information  about  stock  options
        outstanding at December 31, 1999:
<TABLE>
<CAPTION>
                                                                       Plan Options Outstanding
                                                                -------------------------------
                                                                                   1993        Non-       Weighted
                                                     Shares                       Equity     employee      Average
                                                    Available      1983 ISO    Compensation  Director     Exercise
                                                    for Grant        Plan          Plan        Plan         Price
     <S>                                          <C>            <C>           <C>           <C>         <C>
       Balance at December 31, 1996                  211,134        10,311        25,318         250       $69.40

         Additional shares reserved for issuance      93,817
         Granted                                     (11,500)                                 11,500         8.75
         Canceled                                     14,250        (2,601)      (14,250)                   63.80
                                                    --------       -------      --------     -------

       Balance at December 31, 1997                  307,701         7,710        11,068      11,750        49.80

         Additional shares reserved for issuance       3,496
         Granted                                     (97,248)                     97,248                    10.01
         Canceled                                     38,640        (2,274)      (35,307)     (3,333)       55.63
                                                    --------       -------      --------     -------

       Balance at December 31, 1998                  252,589         5,436        73,009       8,417        14.43

         Additional shares reserved for issuance         284
         Granted                                    (220,000)                    200,000      20,000         3.39
         Canceled                                     18,145          (508)      (18,145)                    3.42
                                                    --------       -------      --------     -------

       Balance at December 31, 1999                   51,018         4,928       254,864      28,417       $ 7.12
                                                    ========       =======      ========     =======
</TABLE>
<PAGE>

<TABLE>
<CAPTION>

                                                           Plan Options Outstanding           Options Exercisable

                                                                                Weighted
                                                                   Weighted      Average                  Weighted
                                                                    Average     Remaining                  Average
           Range of                                 Number         Exercise    Contractual    Number      Exercise
        Exercise Prices                           Outstanding        Price        Life      Exercisable     Price
     <S>                                          <C>            <C>             <C>         <C>         <C>
         $2.56 - $8.75                               278,751       $   4.53         8          94,081      $  5.43
        $30.00 - $59.99                                1,376          53.53         3           1,376        53.53
        $60.00 - $89.99                                5,686          71.93         2           5,686        71.93
       $90.00 - $119.99                                  625         102.24         3             625       102.24
       $120.00 - $149.99                               1,271         130.77         3           1,271       130.77
            $153.80                                      500         153.80         3             500       153.80
                                                   ---------                                  -------
                                                     288,209           7.12                   103,539        12.56
</TABLE>

<TABLE>
<CAPTION>

                                                                    Options Outstanding       Options Exercisable
                                                                 ------------------------   ---------------------
                                                                                Weighted                  Weighted
                                                 Range of                        Average                   Average
                                                 Exercise           Number      Exercise      Number      Exercise
              Option Plan                         Prices          Outstanding     Price     Exercisable     Price
    <S>                                   <C>                    <C>           <C>         <C>          <C>
       1983 Incentive Stock Option Plan     $48.80 - $143.80          4,928       $97.03        4,928      $ 97.03
       1993 Equity Compensation Plan         $2.56 - $153.80        254,864         5.43       85,466         7.92
       Nonemployee Director Plan            $8.75 - $  92.60         28,417         6.69       13,145        11.04
                                                                  ---------                   -------
                                                                    288,209         7.12      103,539        12.56
</TABLE>

        Nonqualified  Stock Options - At December 31, 1999,  1998, and 1997, the
        Company had 102,054, 102,054, and 2,055,  respectively,  of nonqualified
        stock options  outstanding to certain current and former officers of the
        Company.  The weighted  average  exercise  price of  nonqualified  stock
        options outstanding was $10.42, $10.42, and $91.77 at December 31, 1999,
        1998,  and 1997,  respectively.  The shares of common  stock  covered by
        nonqualified  options are  restricted  as to transfer  under  applicable
        securities laws.

        Qualified  Employee  Stock  Purchase  Plan - The Company has a Qualified
        Employee  Stock  Purchase  Plan  (the  Purchase  Plan)  under  which all
        employees  meeting certain criteria may subscribe to and purchase shares
        of common stock.  The number of shares of common stock  authorized to be
        issued under the Purchase Plan is 150,000. The subscription price of the
        shares is 85% of the fair  market  value of the common  stock on the day
        the executed  subscription form is received by the Company. The purchase
        price for the shares is the lesser of the  subscription  price or 85% of
        the fair market  value of the shares on the day the right to purchase is
        exercised.  Payment for common stock is made through a payroll deduction
        plan.

        The  Company  applies  APBO No.  25,  Accounting  for  Stock  Issued  to
        Employees,   and  related   interpretations,   in  accounting   for  its
        stock-based compensation plan. Accordingly,  no compensation expense has
        been recognized for its stock option awards,  because the exercise price
        of all options  equals the market  price of the stock on the grant date.
        Had  compensation  expense for the  Company's  stock option  awards been
        determined  based upon their grant date fair value  consistent  with the
        methodology  prescribed  under SFAS No. 123,  Accounting for Stock-Based
        Compensation, the Company's net income (loss) and basic and diluted loss
        per share would have been $987,000 and $0.34 per share, $(2,746,000) and
        $(0.95) per share,  and $(87,000) and $(0.03) per share for 1999,  1998,
        and 1997, respectively.  The fair value of the options at the grant date
        was  estimated  using  the   Black-Scholes   model  with  the  following
        assumptions:
<PAGE>


                                            1999            1998           1997

       Expected life (years)                 5               5              5
       Interest rate                       5.875%          4.25%           6.0%
       Volatility                           61.9%          90.5%         103.0%
       Dividend yield                         0%             0%             0%

        The weighted  average fair value of options  granted in 1999,  1998, and
        1997 was $1.97, $5.22, and $5.80 per share, respectively.

6.      EARNINGS (LOSS) PER SHARE

        The  following  table sets forth the  computation  of basic and  diluted
        earnings  (loss)  per  common  share  (in  thousands,  except  per share
        amounts):
<TABLE>
<CAPTION>

                                                                       1999             1998              1997
     <S>                                                       <C>               <C>               <C>
        Net income (loss) (A)                                     $        1,419    $      (2,297)   $           25
                                                                  ==============    =============    ==============
        Weighted average number of basic common
         shares outstanding (B)                                        2,902,087        2,893,399         2,566,966
        Dilutive effect of stock options computed
         based on the treasury stock method using
         average market price                                             83,020
                                                                  --------------    --------------   --------------
        Weighted average number of diluted
         common shares outstanding (C)                                 2,985,107        2,893,399         2,566,966
                                                                  ==============    =============    ==============
        Basic earnings (loss) per common share (A/B)              $        0.49     $       (0.79)   $        0.01
                                                                  =============     =============    =============
        Diluted earnings (loss) per common share (A/C)            $        0.48     $       (0.79)   $        0.01
                                                                  =============     =============    =============
</TABLE>

7.      LEASES

        The Company leases office and research  facilities from a director under
        a month-to-month  operating lease.  Rental payments to the director were
        approximately  $121,000,  $122,000,  and  $121,000  for the years  ended
        December 31, 1999, 1998, and 1997, respectively.

        The Company  leases other offices and  facilities  and office  equipment
        under  certain  operating  leases which expire on various  dates through
        March 2002.  Under the terms of the facility leases, a pro rata share of
        operating expenses and real estate taxes are charged as additional rent.
        See also  Note 8  regarding  restructuring  costs  relative  to  certain
        facility leases.  The Company subleases one of its facilities to another
        party whereby that party makes payments directly to the lessor.

        As of December 31, 1999,  the Company is  obligated  for future  minimum
        lease payments  (excluding  payments under the leases vacated as part of
        the 1997 restructuring  discussed in Note 8) without regard for sublease
        payments under noncancelable leases as follows (in thousands):
<PAGE>
                                                    Capital      Operating
                                                    Leases       Leases

        2000                                        $  249       $   925
        2001                                           173           641
        2002                                           108           139
        2003                                            64
        2004                                           120
        2005 and thereafter                             56
                                                    ------       -------
                                                       770       $ 1,705
                                                                 =======
        Amount representing interest                   175
                                                     ------
        Present value of net minimum lease payments    595
        Less current portion                           186
                                                    ------
        Long-term capital lease obligations         $  409
                                                     ======


        Rent  expense  (including  amounts  for the  facilities  leased from the
        director)  amounted to $773,000,  $751,0000,  and $582,000 for the years
        ended December 31, 1999, 1998, and 1997, respectively.

8.      RESTRUCTURING COSTS

        In 1996, the Company  closed two facilities  located in Illinois and New
        Jersey and recorded  restructuring costs relating to the remaining lease
        obligations and to the reduction in its work force at those facilities.

        In 1997,  restructuring  reserves decreased by $1,017,000 to $786,000 at
        December  31,  1997,  due to payments of $620,000  and a decrease in the
        estimate of the required  reserve of $397,000 in December  1997 based on
        settlement  offers  received  by the Company  relative to certain  lease
        contingencies originally accrued for in 1996.

        In 1998,  restructuring  reserves increased by $369,000 to $1,155,000 at
        December  31,  1998,  due to payments of $342,000 and an increase in the
        estimate of the  required  reserve of $711,000 in the fourth  quarter of
        1998 resulting from  preliminary  unfavorable  court rulings relative to
        certain lease contingencies originally accrued for in 1996.

        In 1999,  restructuring  reserves decreased by $686,000 to $469,000, due
        to payments of $521,000 and a decrease in the reserve of $165,000 due to
        a more favorable  settlement of certain lease  contingencies  originally
        accrued for in 1998.

9.      INCOME TAXES

        Deferred  income taxes reflect the tax effects of temporary  differences
        between the carrying  amounts of assets and  liabilities  for  financial
        reporting purposes and the amounts used for income tax purposes.

        Significant  components of the Company's  deferred tax liabilities and
        assets are as follows (in thousands):
<PAGE>
<TABLE>
<CAPTION>

                                                                                             1999         1998
     <S>                                                                            <C>             <C>
        Deferred tax liability -
         Equipment and improvements                                                     $       (163)  $      (194)

        Deferred tax assets:
         Goodwill                                                                              1,196         1,421
         Medical reserve                                                                          11           104
         Net operating loss carryforwards                                                     13,379        13,523
         Research and experimental credit carryforwards                                          134            65
         Restructuring costs                                                                     178           439
         Legal reserve                                                                             3            68
         Other                                                                                   233           284
                                                                                        ------------   -----------
        Total net deferred tax assets                                                         14,971        15,710
        Valuation allowance for deferred tax assets                                          (14,971)      (15,710)
                                                                                        ------------   -----------
        Net deferred tax asset                                                          $         -    $        -
                                                                                        ============   ===========

</TABLE>

        Following is a  reconciliation  of federal income tax at the statutory
        rate of 34% to the actual income taxes provided for:
<TABLE>
<CAPTION>

                                                                         1999              1998             1997
    <S>                                                             <C>              <C>               <C>
       Computed expected federal income tax
         expense (benefit)                                             $     482        $    (781)        $       9
       State tax, net of federal effect                                       40             (134)                1
       Permanent differences                                                  10               12                14
       Change in valuation allowance                                        (739)            (671)            1,129
       Adjustment to prior year provision                                                   1,574            (1,153)
       Expired net operating loss carryforwards                              249
       Other                                                                 (42)
                                                                       ---------        ---------         ---------
                                                                       $      -         $      -          $      -
                                                                       =========        =========         =========
</TABLE>

        At December 31, 1999, the Company had net operating  loss  carryforwards
        (NOL) of approximately $35,207,000 which are available to offset taxable
        income through 2014 and began to expire in 1999. For financial reporting
        purposes, a valuation allowance has been recorded to offset deferred tax
        assets that might not be realized.

        Section  382  of  the  Internal   Revenue  Code   restricts  the  annual
        utilization of the NOLs incurred prior to a change in ownership.  Such a
        change  in  ownership  may  have  occurred  in  connection   with  stock
        transactions  in 1996, and another change in ownership may have occurred
        in connection  with the  conversion of Series A Preferred  Stock in 1997
        and  1998.  As a result  of  these  changes  in  ownership,  the  future
        availability of the NOL to offset taxable income is likely substantially
        curtailed.

10.     EMPLOYEE BENEFIT PLAN

        The  Company  has  a  defined  contribution  benefit  plan  that  covers
        substantially  all  employees who meet certain age and length of service

<PAGE>

        requirements.  Contributions  to the plan are at the  discretion  of the
        Board of Directors.  The 401(k) expense for the years ended December 31,
        1999, 1998, and 1997 was $135,000, $98,000, and $152,000, respectively.

11.     COMMITMENTS AND CONTINGENCIES

        In May 1999, the Company  settled a lawsuit in the Circuit Court of Cook
        County,  Illinois.  The suit was  brought  by a  previous  landlord  who
        alleged  that the Company  breached  the terms of a lease in  connection
        with the asset acquisition of MEDTOX Laboratories. In December 1998, the
        Court had granted summary  judgment  against the Company on the issue of
        liability. The Company settled this matter in May 1999 for $685,000. The
        Company had  previously  accrued  $850,000 at December 31, 1998 for this
        contingency.

        In February  1999,  the Company  settled a claim of patent  infringement
        with United  States Drug  Testing  Laboratories  who  asserted the claim
        against the Company on August 20, 1996.  It was alleged that the Company
        infringed  two patents  allegedly  owned by United  States Drug  Testing
        Laboratories  relating  to  forensically  acceptable  determinations  of
        gestational  fetal  exposure  to drugs and other  chemical  agents.  The
        Company, while denying any infringement,  has settled with United States
        Drug  Testing   Laboratories   and  paid  United   States  Drug  Testing
        Laboratories  $17,500  in cash and issued  United  States  Drug  Testing
        Laboratories 2,500 shares of common stock.

        On January 31, 1997, the Company filed suit in Federal District Court in
        Minnesota  against  a  majority   shareholder  and  two  former  outside
        directors  of the  Company  alleging  violation  of  Section  16b of the
        Securities  Exchange  Act of 1934  and  seeking  recovery  of more  than
        $500,000 in short-swing  profits.  On August 4, 1997, the U.S.  District
        Court granted the defendants' Motion to Dismiss the Company's complaint,
        ruling that the  defendants'  conduct did not  constitute a violation of
        Section 16(b).  On October 29, 1997, the Company filed an appeal of that
        decision to the United  States  Court of Appeals for the Eighth  Circuit
        (Court of Appeals).  On July 21, 1998, the Court of Appeals reversed the
        U.S.  District Court's  dismissal and remanded the case back to the U.S.
        District  Court.  On June 3,  1999,  the  U.S.  District  Court  for the
        District of Minnesota ruled in favor of the Company in its claim against
        the  defendants.  The U.S.  District Court found that the defendants had
        violated  Section  16(b) and ordered the  defendants  to pay the Company
        damages of $551,000 plus interest. It is likely that the defendants will
        appeal  the  decision  to the  Court of  Appeals.  The  Company  has not
        recorded a  receivable  for this  amount due to the  uncertainty  of the
        matter.

<PAGE>



SCHEDULE II-VALUATION & QUALIFYING ACCOUNTS
<TABLE>
<CAPTION>

                                              Balance at    Charged to      Charged to                       Balance at
                                              Beginning      Costs and         Other                         the End of
                                              of Period      Expenses        Accounts     Deductions           Period
                                           ------------------------------  -----------------------------------------------
<S>                                      <C>              <C>            <C>          <C>                <C>
Year ended December 31,1999
     Deducted from Asset Accounts
          Allowance for Doubtful Accounts   $     245,000  $  229,000      $     -      $     200,000 (1)  $   274,000
     Restructuring Accrual                  $   1,155,000  $ (165,000)(5)  $     -      $     521,000 (4)  $   469,000

Year ended December 31,1998
     Deducted from Asset Accounts
          Allowance for Doubtful Accounts   $     515,000  $   42,000      $     -      $     312,000 (1)  $   245,000
     Restructuring Accrual                  $     786,000  $  711,000 (3)  $     -      $     342,000 (3)  $ 1,155,000

Year ended December 31,1997
     Deducted from Asset Accounts
          Allowance for Doubtful Accounts   $     358,000   $ 157,000      $     -      $          -       $   515,000
     Restructuring Accrual                  $   1,803,000   $       -      $     -      $   1,017,000 (2)  $   786,000
</TABLE>

(1)  Uncollectible accounts written off, net of recoveries.
(2)  Includes reduction of $397,000 of Lease Liability deemed to no longer be an
     obligation  to the Company.  The  remainder  is due in payments  toward the
     liability.
(3)  Represents payments of lease obligations and an increase of estimate
     on future lease payments.
(4)  Represents payments of lease obligations.
(5)  Represents a decrease in reserves due to a more favorable settlement of
     certain lease contingencies originally accrued for in 1998.




                                                                   Exhibit 3.6
                            CERTIFICATE OF AMENDMENT
                          CERTIFICATE OF INCORPORATION
                                       OF
                             MEDTOX SCIENTIFIC, INC.

     MEDTOX  Scientific,  Inc., a corporation  organized and existing  under the
General  Corporation  Law of the State of  Delaware  (the  "Corporation"),  does
hereby certify that:

         The amendment to the  Corporation's  Certificate of  Incorporation  set
forth  in the  following  resolutions  approved  by the  Corporation's  Board of
Directors and stockholders was duly adopted in accordance with the provisions of
section 242 of the General Corporation Laws of the State of Delaware:

         "RESOLVED,  that the Certificate of Incorporation of the corporation be
amended by striking Article FOURTH in its entirety and replacing therefor:

         'FOURTH:  The total  number of  shares of stock  which the  Corporation
shall have  authority  to issue is SEVEN  MILLION FOUR  HUNDRED  FIFTY  THOUSAND
(7,450,000)  shares,  SEVEN MILLION FOUR HUNDRED  THOUSAND  (7,400,000) of which
shall be of a class designated as Common Stock with a par value of FIFTEEN CENTS
($0.15)  per  share  and  FIFTY  THOUSAND  (50,000)  of  which  shall be a class
designated as Preferred  Stock with a par value of ONE DOLLAR ($1.00) per share.
All or any part of the authorized capital stock of the Corporation may be issued
and  sold,  from  time to time by the  corporation,  without  further  action by
stockholders,  for such  consideration (but not less than the par value thereof)
and to such persons and on such terms and  conditions as may, from time to time,
be  fixed  or  determined  by  the  Board  of  Directors.   The  voting  powers,
designations,  preferences,  and  relative,  participating,  optional  or  other
special rights and the qualifications,  limitations or restrictions  thereof, of
the classes of stock of the corporation  which are fixed by this  Certificate of
Incorporation,  and the  authority  vested in the Board of  Directors  to fix by
resolution or resolution  providing for the issue of Preferred  Stock the voting
powers, designations, preferences and relative, participating, optional or other
special rights, and the qualifications,  limitations or restrictions thereof, of
the  shares  of  Preferred  Stock  which  are not  fixed by the  Certificate  of
Incorporation, are as follows:

         1. The  Preferred  Stock may be issued from time to time in one or more
series, each such series to have such distinctive designation or title as may be
fixed by the Board of  Directors  prior to the  issuance of any shares  thereof.
Each such series may differ from every other series  already  outstanding as may
be determined  from time to time by the Board of Directors prior to the issuance
of any shares thereof, in any or all of the following, but in other, respects:

                  (a) The rate of dividend which the Preferred Stock of any such
series shall be entitled to receive,  whether the dividends of such series shall
be cumulative or non-cumulative and, if such dividends shall be cumulative,  the
date from which they shall be cumulative.

                  (b) The right or  obligation,  if any, of the  corporation  to
redeem  shares of  Preferred  Stock of any series and the amount per share which
the  Preferred  Stock of any such series shall be entitled to receive in case of
the redemption thereof, and the right of the corporation, if any, to reissue any
such shares after the same shall have been redeemed.

                  (c) The amount per share which the Preferred Stock of any such
series  shall be  entitled  to  receive  in case of the  voluntary  liquidation,
distribution or sale of assets, dissolution or winding up of the corporation, or
in  case  of the  involuntary  liquidation,  distribution  or  sale  of  assets,
dissolution or winding up of the corporation.

                  (d) The right,  if any, of the holders of  Preferred  Stock of
any such  series to convert  the same into other  classes of stock and the terms
and conditions of such conversion.
<PAGE>

                  (e) The voting  power,  if any,  of the  holders of  Preferred
Stock of any such  series,  and the terms and  conditions  under  which they may
exercise such voting power.

     (f) The terms of the sinking fund or fund of similar nature,  if any, to be
provided for the Preferred Stock of any such series.

         The  description  of terms of the  Preferred  Stock of each  series  in
respect of the foregoing  particulars shall be fixed and determined by the Board
of  Directors  by  appropriate  resolution  at or  prior  to  the  time  of  the
authorization of the issue of the original shares of each such series.

         2. In case the stated dividends and the amounts payable on liquidation,
distribution or sale of assets, dissolution or winding up of the corporation are
not paid in full, the  stockholders  of all series of the Preferred  Stock shall
share ratably in the payment of dividends,  including accumulations,  if any, in
accordance  with the same which would be payable on such shares if all dividends
were declared and paid in full and in any  distribution  of assets other than by
way of  dividends,  in  accordance  with the sums which would be payable on such
distribution if all sums payable were discharged and paid in full.

         3. The  holders of the  Preferred  Stock  shall be entitled to receive,
when and as declared by the Board of Directors,  out of funds legally  available
therefor,  preferential  dividends in cash at, but not exceeding the annual rate
fixed for each particular  series.  The holders of the Preferred Stock shall not
be entitled to receive any dividends thereon other than dividends referred to in
this Subdivision 3.

         4. So long as any of the  Preferred  Stock remains  outstanding,  in no
event shall any dividend whatever, whether in cash or other property (other than
shares of Common Stock),  be paid or declared or any distribution be made on the
Common Stock, nor shall any shares of the Common Stock be purchased,  retired or
otherwise  acquired for a consideration  by the corporation  unless (a) the full
dividends  of the  Preferred  Stock  for all  past  dividend  periods  from  the
respective date or then current  quarter-yearly  dividend period shall have been
paid or declared and a sum set apart sufficient for the payment thereof, and (b)
if at any time he corporation is obligated to retire shares of any series of the
Preferred  Stock pursuant to a sinking fund or a fund of a similar  nature,  all
arrears, if any, in respect of the retirement of the Preferred Stock of all such
series shall have been made good.  Subject to the foregoing  provisions  and not
otherwise,  such  dividends  (payable  in cash,  stock or  otherwise)  as may be
determined  by the Board of  Directors  may be  declared  and paid on the Common
Stock from time to time out of the remaining  funds of the  corporation  legally
available therefor, and the Preferred Stock shall not be entitled to participate
in any such dividend, whether payable in cash, stock or otherwise.

         5. In the event of any  liquidation,  distribution  or sale of  assets,
dissolution or winding up of the corporation,  whether voluntary or involuntary,
before any distribution or payment shall be made to the holders of Common Stock,
the holders of the  Preferred  Stock of each series shall be entitled to be paid
in cash the  applicable  liquidation  price per  share  fixed at the time of the
original authorization of issuance of shares of such respective series, together
with a sum in the case of each share of the  Preferred  Stock,  computed  at the
annual  dividend  on such share  because  cumulative  to the date fixed for such
distribution or payment date paid thereon.  If such payment shall have been made
in full to the holders of the Preferred Stock, the remaining assets and funds of
the  corporation  shall be  distributed  among the  holders of the Common  Stock
according to their respective shares.

         6. Subject to the powers, preferences and rights and the qualification,
limitations  and  restrictions  thereof,  with  respect to each class of capital
stock of the  corporation  having any  preference  or  priority  over the Common
Stock,  the  holders  of the Common  Stock  shall  have and  possess  all rights
appertaining  to capital stock of the  corporation.  Holders of Common Stock may
not act by written consent without a meeting."
<PAGE>

         "RESOLVED,  that the Certificate of Incorporation of the corporation be
amended by striking  Article  FIFTH,  Section 1, in its entirety  and  replacing
therefor:

     FIFTH:  For the  management  of the  business  and for the  conduct  of the
affairs of the Corporation and in further definition,  limitation and regulation
of the powers of the  Corporation and of its directors and  stockholders,  it is
further provided:

         1. The number of  directors of the  Corporation  shall not be less than
three nor more than twelve, the exact number within said limits to be fixed from
time to time by the vote of a majority  of the  directors  then in  office.  The
Board of Directors  shall be divided  into three  classes,  designated  Class I,
Class II and Class III, as nearly equal in number as  possible,  and the term of
office  of  Directors  of one  class  shall  expire at each  annual  meeting  of
stockholders,  and in all cases as to each Director until his successor shall be
elected and shall qualify or until his earlier resignation, removal form office,
death or  incapacity.  Additional  directorships  resulting  from an increase in
number of  Directors  shall be  apportioned  among the  classes  as  equally  as
possible. The initial term of office of Directors of Class I shall expire at the
annual  meeting of  stockholders  in 2000;  that of Class II shall expire at the
annual meeting in 2001; and that of Class III shall expire at the annual meeting
in 2002;  and in all  cases as to each  director  until his  successor  shall be
elected and shall qualify or until his earlier resignation, removal from office,
death or  incapacity.  At each  annual  meeting  of  stockholders  the number of
Directors  equal to the number of  Directors  of the class whose term expires at
the time of such  meeting  (or,  if  less,  the  number  of  Directors  properly
nominated and qualified for election)  shall be elected to hold office until the
third succeeding annual meeting of stockholders after their election.

         In case of any  vacancies,  by reason of an  increase  in the number of
directors,  resignation or otherwise,  directors to fill such vacancies shall be
elected by a majority of the directors then in office,  and any such director so
elected shall hold office until the next succeeding election of directors in the
Class to which such director is assigned."

     IN WITNESS WHEREOF, MEDTOX Scientific,  Inc. has caused this Certificate to
be signed and  attested by its duly  authorized  officers  this 11th of October,
1999.

                                        MEDTOX Scientific, Inc.




                                        By:________________________
                                        Harry G. McCoy
                                        President


ATTEST:

- ---------------------
Kevin Wiersma




                                                                    Exhibit 4.1
                             [FORM OF FACE OF NOTE]
No.                                                                  $_______

                             MEDTOX SCIENTIFIC, INC.

                         12% SUBORDINATED NOTE DUE 2001

         MEDTOX  SCIENTIFIC,  INC., a  corporation  duly  organized and existing
under the laws of the State of Delaware (herein called the "Company"), for value
received,  hereby promises to pay to ____________________ or registered assigns,
the principal  sum of __________  dollars on December 31, 2001, at the principal
office of the Company in such coin or  currency of the United  States of America
as at the time of payment  shall be legal  tender for the  payment of public and
private debts, and to pay interest,  semi-annually on June 30 and December 31 of
each year,  on said  principal  sum at said  office or  agency,  in like coin or
currency,  at the rate per annum  specified  in the title of this Note,  as more
fully provided on the reverse hereof.

         Reference is made to further  provisions  of this Note set forth on the
reverse hereof,  including,  without  limitation,  provisions  subordinating the
payment of  principal  of and  premium,  if any, and interest on the Note to the
prior payment in full of all Senior Indebtedness, as defined herein.

     IN WITNESS WHEREOF,  MEDTOX SCIENTIFIC,  INC. has caused this instrument to
be  executed  in its  corporate  name by its  Chairman  or its  Chief  Executive
Officer,  attested by the manual or facsimile  signature of its  Secretary or an
Assistant Secretary.


                                           MEDTOX SCIENTIFIC, INC.



                                        By  _________________________________


Attest:



____________________________________        Dated:  __________, 1999


<PAGE>

                                [REVERSE OF NOTE]

                             MEDTOX SCIENTIFIC, INC.

                         12% SUBORDINATED NOTE DUE 2001

1.       Interest.

         Medtox  Scientific,  Inc.,  a  Delaware  corporation  (the  "Company"),
promises to pay  interest on the  principal  amount of this Note at the rate per
annum  shown  above  semi-annually  on June  30 and  December  31 of  each  year
("Interest  Payment  Date").  Interest  will accrue from the most recent date to
which  interest has been paid,  unless no interest has been paid,  in which case
from the date of this Note. The record date for the payment of interest shall be
June 15 and December 15 of each year.  Interest will be computed on the basis of
a 360-day year of twelve 30-day months.

2.       Method of Payment.

         The  Company  will pay  interest  (except  defaulted  interest)  to the
registered  holder of the Note at the close of business on the Record Date.  The
Company will pay  principal  and interest in money of the United  States that at
the time of payment is legal  tender for  payment of public and  private  debts.
However,  the Company may pay principal and any interest by its check payable in
such money. It may mail an interest check to a holder's registered address.

3.       Paying Agent and Registrar.

         Initially,  the Company  will act as Paying  Agent and  Registrar.  The
Company may change any Paying Agent, Registrar or co-Registrar without notice.

4.       Unsecured Obligation.

         This Note is a general  unsecured  obligation of the Company limited to
the aggregate principal amount set forth on the face of this Note.

5.       No Redemption; No Sinking Fund.

         This Note may not be  redeemed  or repaid by the  Company  prior to its
maturity date. This Note will not have the benefit of sinking fund payments.


<PAGE>


         6.1      Subordination.

                  The Company, for itself and its successors and assigns, agrees
         and the holder by his  acceptance  of this Note agrees that the payment
         of the principal of and interest on this Note is  subordinated,  to the
         extent and in the manner hereinafter set forth, to the prior payment in
         full of all Senior Indebtedness.

         6.2      Company not to Make Payments with Respect to Note in Certain
         Circumstances.

                  (a) Upon the maturity of any Senior  Indebtedness  by lapse of
         time,  acceleration  or otherwise,  all principal  thereof and interest
         thereon  shall first be paid in full, or such payment duly provided for
         in cash or in a manner  satisfactory  to the  holder or holders of such
         Senior  Indebtedness,  before  any  payment  is made on  account of the
         principal  of or interest on this Note or to acquire this Note for cash
         or property other than capital stock of the Company.

                  (b) Upon the  happening of an event of default (or if an event
         of default  would  result upon any payment  with  respect to this Note)
         with  respect to any Senior  Indebtedness,  as such event of default is
         defined  therein or in the  instrument  under which it is  outstanding,
         permitting the holders to accelerate the maturity thereof,  and, if the
         default  is other  than  default  in  payment  of the  principal  of or
         interest on such Senior Indebtedness, upon written notice thereof given
         to the Company by the holder or holders of such Senior  Indebtedness or
         their respective or representatives,  then, unless and until such event
         of default  shall  have been  cured or waived or shall  have  ceased to
         exist,  no payment  shall be made by the  Company  with  respect to the
         principal  of or interest on this Note or to acquire this Note for cash
         or property other than capital stock of the Company.

         6.3      Note Subordinated to Prior Payment of all Senior  Indebtedness
         on Dissolution, Liquidation or Reorganization of Company.

                  Upon  any  distribution  of  assets  of the  Company  upon any
         dissolution,  winding up,  liquidation or reorganization of the Company
         (whether in bankruptcy,  insolvency or receivership proceedings or upon
         an assignment for the benefit of creditors or otherwise):

                  (a) The  holders of all  Senior  Indebtedness  shall  first be
         entitled to receive  payment in full of the  principal and interest due
         thereon  before the  holder of this Note is  entitled  to  receive  any
         payment on account of the principal of or interest  (other than payment
         in shares of stock of the  Company as  reorganized  or  readjusted,  or
         securities  of the Company or any other  corporation  provided for by a
         plan of reorganization or readjustment,  which stock and securities are
         subordinated to the payment of all Senior  Indebtedness  and securities
         received in lieu thereof which may at the time be outstanding); and

                  (b) Any  payment or  distribution  of assets of the Company of
         any kind or character,  whether in cash,  property or securities (other
         than shares of stock of the Company as reorganized ore  readjusted,  or
         securities  of the Company or any other  corporation  provided for by a
         plan of reorganization or readjustment,  which stock and securities are
         subordinated to the payment of all Senior  Indebtedness  and securities
         received  in lieu  thereof  which may at the time be  outstanding),  to
         which  the  holder  of this  Note  would  be  entitled  except  for the
         provisions hereof, shall be paid by the liquidating trustee or agent or
         other  person  making  such  payment or  distribution  directly  to the
         holders   of   Senior   Indebtedness   or   their   representative   or
         representatives  to the extent necessary to make payment in full of all
         Senior  Indebtedness  remaining  unpaid,  after  giving  effect  to any
         concurrent payment or distribution or provision therefor to the holders
         of such Senior Indebtedness.
<PAGE>
                  (c) In the event that notwithstanding the foregoing provisions
         of this Note, any payment or  distribution  of assets of the Company of
         any kind or character,  whether in cash,  property or securities (other
         than shares of stock of the Company as reorganized  or  readjusted,  or
         securities  of the Company or any other  corporation  provided for by a
         plan of  reorganization  or adjustment,  which stock and securities are
         subordinated to the payment of all Senior  Indebtedness  and securities
         received in lieu thereof which may at the time be  outstanding),  shall
         be  received  by the holder on account of  principal  of or interest on
         this Note before all Senior  Indebtedness is paid in full, or effective
         provision made for its payment,  such payment or distribution  shall be
         received and held in trust for and shall be paid over to the holders of
         the Senior  Indebtedness  remaining  unpaid or unprovided  for or their
         representative  or  representatives,  for application to the payment of
         such Senior  Indebtedness until all such Senior Indebtedness shall have
         been paid in full,  after giving  effect to any  concurrent  payment or
         distribution  or  provision  therefor  to the  holders  of such  Senior
         Indebtedness.

         6.4      Holder to be Subrogated to Right of Holders of Senior
         Indebtedness.

                  Subject to payment  in full of all  Senior  Indebtedness,  the
         holder of this Note shall be subrogated to the rights of the holders of
         Senior  Indebtedness to receive  payments or distributions of assets of
         the Company  applicable  to the Senior  Indebtedness  until all amounts
         owing on this Note shall be paid in full,  and for the  purpose of such
         subrogation no payments or  distributions  to the holders of the Senior
         Indebtedness  by or on behalf of the  Company or by or on behalf of the
         holders of this Note which otherwise would have been made to the holder
         shall,  as between the Company and the holder,  be deemed to be payment
         by the  Company  to or on  account  of  Senior  Indebtedness,  it being
         understood that the provisions of this Note are and are intended solely
         for the purpose of defining the relative  rights of the holder,  on the
         one hand, and the holders of Senior Indebtedness on the other hand.

         6.5      Obligation of the Company Unconditional.

                  Nothing  contained in this Note or elsewhere is intended to or
         shall  impair as between the  Company and the holder of this Note,  the
         obligation of the Company, which is absolute and unconditional,  to pay
         to the holder the  principal  of and  interest on this Note as and when
         the same shall  become due and  payable  in  accordance  with the terms
         hereof,  or is intended to or shall affect the  relative  rights of the
         holder and  creditors  of the  Company  other  than the  holders of the
         Senior Indebtedness,  nor shall anything herein prevent any holder from
         exercising  all remedies  otherwise  permitted by  applicable  law upon
         default under this Note,  subject to the rights, if any, of the holders
         of Senior Indebtedness in respect of cash,  property,  or securities of
         the Company received upon the exercise of any such remedy.

         6.6 Definition of Senior Indebtedness. "Senior Indebtedness" shall mean
         (a) the principal of and premium,  if any, and interest on indebtedness
         or any other  obligation  of the  Company,  outstanding  on the date of
         execution  of this  Note  (i) for  money  borrowed  by the  Company  or
         representing purchase money indebtedness of the Company or evidenced by
         debentures,  notes  or  other  corporate  debt  securities  or  similar
         instruments  issued by the Company,  or (ii) under any written contract
         or  commitment  for  the  leasing,   purchase  or  other   acquisition,
         possession or use of equipment or facilities  related to the operations
         of the  Company or any of its  subsidiaries,  or (iii)  constituting  a
         guarantee  of  indebtedness  of an  obligation  of  others of the types
         referred to in the preceding clauses (i) and (ii), or (iv) constituting
         a  renewal,  extension  or  refunding  of any of  the  indebtedness  or
         obligations  referred to in the  preceding  clauses (i), (ii) and (iii)
         unless,  in each case,  under the express  provisions of the instrument
         creating  or  evidencing  the same,  or  pursuant  to which the same is
         outstanding,  such  indebtedness  or other  obligation or such renewal,
         extension or  refunding  thereof is not superior in right of payment to
         the Note; and (b) any  indebtedness or other  obligation of the Company
         of any of the types  referred to in the  preceding  clause (a) created,
         incurred  or  assumed  on or after the date of  execution  of this Note

<PAGE>

         which,  under the  express  provisions  of the  instrument  creating or
         evidencing the same, or pursuant to which the same is  outstanding,  is
         superior in right of payment to this Note.

7.       Persons Deemed Owners.

         The registered  holder of this Note shall be treated as the owner of it
for all purposes.

8.       Successor Corporation.

         When  a  successor  corporation  assumes  all  the  obligations  of its
predecessor  under this Note, the predecessor  corporation will be released from
those obligations.

9.1      Events of Default.

                  An "Event of Default" occurs if:

                  (1) the  Company  defaults  in the payment of interest on this
         Note when the same  becomes due and  payable and the default  continues
         for a period of 30 days (whether or not such payment was  prohibited by
         Section 6 hereof);

                  (2) the Company  defaults in the payment of the  principal  of
         this  Note  when  the same  becomes  due and  payable  at  maturity  or
         otherwise  (whether  or not such  payment was  prohibited  by Section 6
         hereof);

                  (3)  the  Company  fails  to  comply  with  any of  its  other
         agreements  contained in this Note and such default  continues  for the
         period and after the notice specified below;

                  (4)      the Company pursuant to or within the meaning of any
         Bankruptcy Law:

                           (a)      commences a voluntary case or proceeding,

                           (b)      consents to the entry of an order for relief
                           against it in an involuntary case or proceeding,

                           (c)      consents to the appointment of a custodian
                           of it or for all or substantially all of its
                           property, or

                           (d)      makes a general assignment for the benefit
                           of its creditors; or

                  (5)      a court of competent jurisdiction enters an order or
         decree under any bankruptcy law that:

                           (a)      is for relief against the Company in an
                           involuntary case or proceeding;

                           (b)      appoints a custodian of the Company for all
                           or substantially all of its properties, or

                           (c)      orders the liquidation of the Company,

         and in each case the order or decree remains unstayed and in effect for
         90 consecutive days.

                  The term  "Bankruptcy  Law" means Title 11,  U.S.  Code or any
         similar  federal  or state  law for the  relief  of  debtors.  The term
         "Custodian"  means  any  receiver,   trustee,   assignee,   liquidator,
         sequestrator or similar official under any Bankruptcy Law.
<PAGE>

                  A Default  under  clause (3) is not an Event of Default  until
         the holder notifies the Company of the Default and the Company does not
         cure the Default within 30 days after receipt of the notice. The notice
         must specify the Default, demand that it be remedied and state that the
         notice is a "Notice of Default." When a Default is cured, it ceases.

         9.2      Acceleration.

                  If an  Event  of  Default  (other  than an  Event  of  Default
         specified  in Section  9.1 (4) or (5))  occurs and is  continuing,  the
         holder may, by notice to the Company,  declare all unpaid  principal of
         and  accrued  interest  to the date of  acceleration  on this Note then
         outstanding  (if not then due and payable) due and payable and the same
         shall become and be immediately due and payable. If an Event of Default
         specified in 9.1 (4) or (5) occurs, all unpaid principal of and accrued
         interest on this Note then  outstanding  shall ipso facto become and be
         immediately due and payable without any declaration or other act on the
         part of the holder. Upon payment of such principal amount and interest,
         all of the Company's  obligations under this Note shall terminate.  The
         holder by notice to the  Company may  rescind an  acceleration  and its
         consequences  if (i) all  existing  Events of  Default,  other than the
         non-payment  of the  principal of the Notes which has become due solely
         by such declaration of acceleration, have been cured or waived, (ii) to
         the extent the payment of such interest is lawful,  interest on overdue
         installments  of interest  and overdue  principal  which has become due
         otherwise than by such declaration of acceleration,  has been paid, and
         (iii) the rescission  would not conflict with any judgment or decree of
         a court of competent jurisdiction.

         9.3      Other Remedies.

                  If an Event of Default  occurs and is  continuing,  the holder
         may pursue any  available  remedy by  proceeding at law or in equity to
         collect  the  payment of  principal  of or  interest  on the Note or to
         enforce the performance of any provision of the Note.

                  A delay or omission by the holder in  exercising  any right or
         remedy shall not constitute a waiver of or acquiescence in the Event of
         Default.  No remedy is exclusive  of any other  remedy.  All  available
         remedies are cumulative.

                  Except as otherwise  expressly  provided  herein,  the Company
         hereby waives  presentment,  demand for payment,  notice of nonpayment,
         protest,  notice of protest,  notice of dishonor, and all other notices
         in connection herewith, as well as filing of suit (if permitted by law)
         and diligence in collecting  this Note, and agrees to pay (if permitted
         by law) all expenses  incurred in  collection,  including  the holder's
         actual attorneys' fees.

10.      No Recourse Against Others.

         A director,  officer, employee or stockholder,  as such, of the Company
shall not have any liability for any  obligations of the Company under this Note
or for any claim  based on, in respect of or by reason of, such  obligations  or
their  creation.  The holder by  accepting a Note waives and  releases  all such
liability. The waiver and release are part of the consideration for the issue of
this Note.

11.      Abbreviations.

         Customary  abbreviations  may  be  used  in the  name  of a  holder  or
assignee,  such as: TEN COM ( = tenants in  common),  TEN ENT ( = tenants by the
entireties),  JT TEN ( = joint  tenants  with right of  survivorship  and not as
tenants in common), CUST ( = Custodian), and U/G/M/A ( = Uniform Gifts to Minors
Act).
<PAGE>

12.       Governing Law.

         This Note shall be deemed to be a  contract  made under the laws of the
State of Minnesota's, and for all purposes shall be construed in accordance with
the laws of the State of Minnesota.




                                                                   Exhibit 4.2

                NON-TRANSFERABLE WARRANT TO PURCHASE COMMON STOCK

            _______ Shares of Common Stock of MEDTOX Scientific, Inc.

                                                              ___________, 1999

    THIS CERTIFIES THAT,  ________________  (the "Holder"),  is entitled to
subscribe for and purchase from MEDTOX Scientific,  Inc., a Delaware corporation
(the "Company") from December 15, 1999 through December 31, 2001 up to _________
(_______) fully paid and  non-assessable  shares (the "Shares") of the Company's
Common  Stock,  $.15 par value (the  "Common  Stock") at a price of $0.1625  per
share.

         In addition to the aforedescribed  conditions of exercise, this Warrant
is subject to the following provisions, terms and conditions:

         1. Exercise of Warrant.  The purchase rights under this Warrant must be
exercised, in whole or in part, by the Holder surrendering this Warrant with the
form of  subscription  attached  hereto  duly  executed by such  Holder,  to the
Company at its principal office, accompanied by payment, in cash or by certified
or official  bank check  payable to the order of the  Company,  of the  purchase
price payable in respect of the Common Stock being  purchased.  If less than all
of the Common Stock is purchased, the Company will, upon such exercise,  execute
and  deliver  to the  Holder  hereof  a new  Warrant  (dated  the  date  hereof)
evidencing  the number of shares of Common  Stock not so  purchased.  As soon as
practicable  after the  exercise of this  Warrant  and  payment of the  purchase
price,  the Company will cause to be issued in the name of and  delivered to the
Holder  hereof,  or as such Holder may direct,  a  certificate  or  certificates
representing the Shares purchased upon such exercise.

         The Company may require that such  certificate or certificates  contain
on the face thereof a legend substantially as follows:

                  "The securities represented by the within certificate have not
                  been registered  under the Securities Act of 1933, as amended,
                  or under the applicable provisions of any State Blue Sky laws,
                  and may not be sold,  transferred  or  otherwise  disposed  of
                  unless (1) the Company  consents in writing to such  transfer,
                  or (2) at the time of the proposed  transfer,  the  securities
                  are eligible  for public  resale under Rule 144 of the General
                  Rules  and   Regulations   of  the   Securities  and  Exchange
                  Commission under the Securities Act (or successor rule if Rule
                  144 is no longer  then in effect)  and such  transfer  is made
                  pursuant to Rule 144."

     2.  Negotiability  and  Transfer.  This  Warrant may not be sold,  pledged,
gifted or  otherwise  transferred  without  the express  written  consent of the
Company.

     3.  Antidilution  Adjustments.  In  case  the  Company  shall  at any  time
hereafter  subdivide (i.e., stock split) or combine (i.e.,  reverse stock split)
its outstanding  shares of Common Stock, or declare a dividend payable in Common
Stock,  the  exercise  price in  effect  immediately  prior to the  subdivision,
combination  or record  date for such  dividend  payable in Common  Stock  shall
forthwith  be  proportionately  increased,  in  the  case  of  combination,   or
proportionately  decreased,  in the  case of  subdivision  or  declaration  of a
dividend  payable in Common  Stock,  and each share of Common Stock  purchasable
upon  exercise  of the  Warrant  shall be changed to the  number  determined  by
dividing the then current exercise price by the exercise price as adjusted after
such subdivision, combination or dividend payable in Common Stock.
<PAGE>

         No fractional shares of Common Stock are to be issued upon the exercise
of the Warrant,  but the Company  shall pay a cash  adjustment in respect of any
fraction of a share which would  otherwise be issuable in an amount equal to the
same  fraction of the per share value of Common  Stock on the day of exercise as
determined in good faith by the Company.

         In case of any capital  reorganization or any  reclassification  of the
shares of Common Stock of the Company,  or in the case of any consolidation with
or merger of the Company into or with another corporation, or the sale of all or
substantially all of its assets to another  corporation  effected in such manner
that the holders of common shares shall be entitled to receive stock, securities
or assets with respect to or in exchange for Common  Stock,  then,  as a part of
such  reorganization,  reclassification,  consolidation,  merger or sale, as the
case may be,  lawful  provision  shall be made so that the Holder of the Warrant
shall have the right thereafter to receive,  upon the exercise hereof,  the kind
and amount of shares of stock or other  securities or property  which the holder
would  have  been   entitled   to  receive   if,   immediately   prior  to  such
reorganization,  reclassification,  consolidation or merger, the Holder had held
the  number of  shares of Common  Stock  which  were then  purchasable  upon the
exercise of the Warrant. In any such case, appropriate adjustment (as determined
in good faith by the Board of  Directors  of the  Company)  shall be made in the
application  of the  provisions  set forth herein with respect to the rights and
interest thereafter of the Holder of the Warrant, to the end that the provisions
set forth  herein  (including  provisions  with  respect to  adjustments  of the
exercise price) shall thereafter be applicable,  as nearly as reasonably  maybe,
in relation to any shares of stock or other property thereafter deliverable upon
the exercise of the Warrant.

         When any  adjustment  is  required  to be made in the  exercise  price,
initial or adjusted,  the Company  shall  forthwith  determine  the new exercise
price; and

     (a) Prepare and retain on file a statement  describing in reasonable detail
the method used in arriving at the new exercise price; and

     (b)  Cause a copy of such  statement  to be  mailed  to the  Holder  of the
Warrant as of a date within then (10) days after the date when the circumstances
giving rise to the adjustment occurred.

     4. No  Registration  Rights.  No  Holder  of the  Warrant  shall  have  any
registration  rights  under the terms of the Warrant  with respect to either the
Warrant or the securities issuable upon exercise of the Warrant.

     5. Limitation of Rights;  Notices.  The Holder of the Warrant shall have no
voting rights or dividend  rights with respect to the Shares before exercise and
payment  therefor.  The Company shall mail a notice to the registered  Holder of
the Warrant,  at the Holder's  last known post office  address  appearing on the
books of the Company, not less than fifteen (15) days prior to the date on which
(a) a record will be taken for the purpose of determining  the holders of Common
Stock entitled to dividends,  or (b) a record will be taken (of in lieu thereof,
the transfer books will be closed) for the purpose of determining the holders of
Common Stock entitled to notice of and to vote at a meeting of  stockholders  at
which any capital  reorganization,  reclassification  of shares of Common Stock,
consolidation,   merger,  dissolution,   liquidation,  winding  up  or  sale  of
substantially all of the Company's assets shall be considered and acted upon.

     6.  Reservation  of Common  Stock.  A number  of  shares  of  Common  Stock
sufficient  to provide for the exercise of the Warrant upon the basis herein set
forth shall at all times be reserved for the exercise thereof.

     7.  Miscellaneous.  The  representatives,  warranties and agreements herein
contained  shall survive the exercise of the Warrant.  References to the "holder
of" include the  immediate  holders of shares  purchased  on the exercise of the
Warrant, and the words "holder" shall include the plural thereof.
<PAGE>

         All shares of Common Stock or other securities issued upon the exercise
of the Warrant shall be validly issued,  fully paid and  nonassessable,  and the
Company will pay all taxes in respect of the issuer thereof.

     8.  Acknowledgement of the Warrant Holder. The Holder hereby represents and
warrants as follows:


     (a) to the extent  requested,  the Holder has  provided  the  Company  with
complete and accurate  information  concerning  its  knowledge,  experience  and
financial condition;

     (b)  as a  sophisticated  investor,  the  Holder  has  such  knowledge  and
experience  in  financial  business  matters  that it  believes it is capable of
evaluating the merits and risks of the prospective investment in the Warrant;

     (c) the Holder recognizes that investment in the Warrant may involve a high
degree of risk and  immediate  substantial  dilution,  that the  purchase of the
Warrant  maybe a  long-term  investment,  that  transferability  and  resale  is
restricted  and that,  in the event of  disposition  of the  underlying  capital
stock, the undersigned could sustain a loss;

     (d) in connection with the purchase of the Warrant,  the Holder  represents
and warrants that the Holder intends to acquire the Warrant for the Holder's own
account  for  investment  purposes  and  not  with a view  to or for  resale  in
connection with any  distribution  thereof,  and agrees that the Holder will not
sell or assign the Warrant without registration under all applicable  securities
law  or  appropriate  exemption  therefrom.   The  undersigned  understands  and
acknowledges  that the Warrant has not been registered  under the Securities Act
of 1933 nor under  applicable  Blue Sky laws,  pursuant to exemption  therefrom,
which depend upon its investment intention. The undersigned also understands and
acknowledges  that  the  underlying  capital  stock  has not  been  nor  will be
registered  under  applicable  securities  laws and therefore will not be freely
transferable  and that the  shares  of  capital  stock  will be  marked  with an
appropriate legend reciting the resale restrictions.

     IN  WITNESS  WHEREOF,  this  Warrant  has  been  duly  executed  by  MEDTOX
Scientific, Inc. this __ day of ____________, 1999.

                                      MEDTOX Scientific, Inc.


                                      By__________________________
                                      Its__________________________


         The Holder hereby acknowledges the terms and conditions of the transfer
restrictions herein contained and only executes this Warrant for that purpose.



                                                                  Exhibit 10.44
                              EMPLOYMENT AGREEMENT

          THIS   AGREEMENT,   dated  January  1,  2000  by  and  between  MEDTOX
Scientific,  Inc., a corporation (the "Company") and Richard J. Braun a resident
of Minnesota ("Executive").

         WHEREAS,  the Company  desires to employ  Executive upon and subject to
the terms and conditions set forth in this agreement,  and Executive  desires to
render services for the Company on such terms and conditions.

         NOW,  THEREFORE,  in  consideration  of the premises and the respective
undertakings  of the  Company and  Executive  set forth  below,  the Company and
Executive agree as follows:

     1 . Definitions.  The following defined terms have the respective  meanings
described below:


     1.1 Change in Control.  A "Change in Control" of the Company shall mean any
of the following:


          (a) a change in  control  of a nature  that  would be  required  to be
     reported  in  response  to Item  6(c) of  Schedule  14A of  Regulation  14A
     promulgated  under the  Securities  Exchange  Act of 1934,  as amended (the
     "Exchange  Act"),  whether  or not  the  Company  is then  subject  to such
     reporting requirement; or

          (b) a merger  or  consolidation  to which the  Company  is a party if,
     following  the  effective  date  of  such  merger  or  consolidation,   the
     individuals and entities who were  shareholders of the Company prior to the
     effective date of such merger or  consolidation  have beneficial  ownership
     (as  defined  in Rule  13d-3  under the  Exchange  Act) of less than  fifty
     percent  (50%) of the combined  voting power of the  surviving  corporation
     following the effective date of such merger or consolidation; or

          (c) when,  during any period of twenty-four  (24)  consecutive  months
     during the term of this Agreement, the individuals who, at the beginning of
     such period, constitute the Board (the "Incumbent Directors") cease for any
     reason  other  than  death  to  constitute  at  least a  majority  thereof,
     provided,  however, that a director who was not a director at the beginning
     of such  twenty-four  (24) month period  shall be deemed to have  satisfied
     such twenty-four (24) month requirement,  and be an Incumbent Director,  if
     such  director  was  elected  by, or on the  recommendation  of or with the
     approval of, at least  two-thirds of the  directors  who then  qualified as
     Incumbent  Directors  either  actually,  because they were directors at the
     beginning of such twenty-four  (24) month period,  or by prior operation of
     this Section.

1.2  Potential Change in Control. A "Potential Change in Control" of the Company
     shall be deemed to have occurred if:


<PAGE>

          (a) the Company enters into an agreement,  the  consummation  of which
     would result in the occurrence of a Change in Control;

          (b) any person (including the Company) publicly announces an intention
     to take or to consider taking actions which if consummated would constitute
     a Change in Control;

          (c) any person becomes the beneficial  owner,  directly or indirectly,
     of securities of the Company  representing ten percent (10%) or more of the
     combined voting power of the Company's then outstanding securities; or

          (d) the Board adopts a resolution to the effect that, for the purposes
     of this  Agreement,  a  "Potential  Change in  Control"  of the Company has
     occurred.

1.3 Cause.  Termination by the Company of the  Executive's  employment
     for "Cause" shall mean termination upon:

          (a)  the  willful  and   continued   failure  by  the   Executive   to
     substantially  perform an  Executive's  duties with the Company (other than
     any such failure  resulting from Executive's  incapacity due to physical or
     mental  illness)  after a written  demand for  substantial  performance  is
     delivered  to the  Executive by the  Company's  Board of  Directors,  which
     demand  specifically  identifies  the manner in which the Company  believes
     that Executive has not substantially performed Executive's duties; or

          (b)  the  willful  engaging  by the  Executive  in  conduct  which  is
     demonstrably  and  materially  injurious  to  the  Company,  monetarily  or
     otherwise.

For purposes of this Section 1.3, no act, or failure to act, on the  Executive's
part shall be deemed  "willful"  unless  done,  or  omitted  to be done,  by the
Executive not in good faith and without  reasonable  belief that the Executive's
action or omission was in the best interest of the Company.

     1.4  Company.  The term  "Company"  means MEDTOX  Scientific.  Inc. and any
successors and assigns of the Company.


2.   Employment.  The  Company  hereby  employs  Executive  as  Chief  Executive
     Officer,  and  Executive  accepts  such  employment  and  agrees to perform
     services  for the  Company,  for the  period  and upon the other  terms and
     conditions set forth in this agreement.

3.   Term of Employment.  The term of Executive's employment hereunder ("Term of
     Employment")  shall  commence on the date hereof and shall  continue  for a
     three year period ending on December 31, 2002 (unless earlier terminated in
     accordance with the provisions of Section 13 of this  agreement).  The Term
     of Employment shall be automatically  extended by successive 12-month terms
     thereafter.

4.   Position and Duties

                  4.1  Service  with  Company.  During  his Term of  Employment,
         Executive  agrees  to  perform  such  reasonable   employment   duties,

<PAGE>

         consistent with the terms of this agreement,  as the Board of Directors
         of the Company  shall assign to him from time to time,  Such duties and
         employment  responsibilities  shall be performed in accordance with the
         Company's rules, regulations and instructions now in force or which may
         be adopted by the Company in the future. During the Executive's Term of
         Employment,  the Board of Directors  shall  nominate  and  recommend to
         shareholders the election of, and vote all shareholder proxies in favor
         of, Executive's election to the Company's Board of Directors.

                  4.2 Performance of Duties. During his Term of Employment,  the
         Executive  agrees to serve the Company  exclusively  and to the best of
         his ability.  The Executive shall have active  involvement and be fully
         committed to the business and affairs of the Company,  and shall devote
         one hundred percent of his business time to the affairs of the Company,
         except for (i) vacations and excused  leaves of absence as permitted in
         accordance with Company policy; (ii) service on the Boards of Directors
         of  other  companies  at the  discretion  of  the  Company's  Board  of
         Directors;  (iii) service on the Boards of Directors of  not-for-profit
         entities without approval of the Company's Board of Directors; and (iv)
         a  reasonable  amount of time  during  the  business  day to handle his
         personal  affairs.  Executive  hereby  confirms  that  he is  under  no
         contractual commitments  inconsistent with his obligations set forth in
         this  agreement  and that  during  his Term of  Employment,  except  as
         provided  herein,  he will not render or perform services for any other
         corporation,  fin-n,  entity or person,  nor will he become involved in
         the operations or management of any other commercial corporation, firm,
         entity or person.

5.   Compensation.

                  5.1 Base Salary. Initial base compensation for all services to
         be rendered by the Executive  under this  agreement  during the Term of
         Employment, the Company shall pay to Executive an annual base salary of
         $250,000 per year,  which salary shall be paid in  accordance  with the
         Company's normal payroll procedures and policies.

          5.2 Annual Bonus Plan. Executive shall participate in the Annual Bonus
     Plan of the Company set forth in Attachment 2 to this Agreement.

          5.3  Performance  Unit  Plan.   Executive  shall  participate  in  the
     Performance  Unit Plan of the  Company  set forth in  Attachment  3 to this
     Agreement.

          5.4 Benefits.  Executive  shall be entitled to such  Company-sponsored
     benefits as are provided to executive employees of the Company,  subject to
     the terms and conditions of the applicable policies and/or plans. Executive
     shall  be  entitled  to the  specific  additional  benefits  enumerated  in
     Attachment 4 to this Agreement.

          5.5  Restricted  Stock.  Executive  shall be  entitled  to  grants  of
     restricted stock as provided in Attachment 5 of this Agreement.

         6. Executive's Agreement to Continue Employment for Six (6) Months. The
Executive agrees that, subject to the terms and conditions of this Agreement, in
the event of a Potential  Change in Control of the Company  occurring during the
Term of Employment, if so requested by the Company, Executive will remain in the
employ of the Company  for a period of six (6) months  after the  occurrence  of
such  Potential  Change in Control of the Company.  If more than one  "Potential
Change in Control" occurs during the Term of Employment,  the provisions of this
Section 6 shall be applicable to each  "Potential  Change of Control"  occurring
prior to the occurrence of a Change in Control.

         7. Severance Payments. If during the Term of Employment, (i) whether or
not a Change in Control or Potential Change in Control has occurred, the Company
terminates  the employment of Executive  other than for Cause,  (ii) a Change in
Control  has  occurred  and  Executive  has  complied  with  Section  6 of  this
Agreement,  or (iii)  the  Executive's  duties,  responsibilities  or  authority

<PAGE>

(including status, office, title, reporting relationships or working conditions)
have been materially altered from those in effect on the date of this Agreement,
(iv) the Executive has been required to relocate to an office or related  entity
more than fifty (50) miles from the office  where  Executive  was located on the
date hereof,  or (v) the Company has breached any of its obligations  under this
Agreement, then, in any such event (at the Executive's option in the case of any
event described in clause (ii) through (v) above),  the  Executive's  employment
hereunder shall cease and Executive shall be entitled to the following benefits:

                  (a)      the Company  will pay to  Executive  the  Executive's
                           then  current  base salary for the greater of (i) the
                           twelve (12) month period  following  the date of such
                           termination,  or  (ii)  the  balance  of the  Term of
                           Employment  hereunder,  in  either  case  subject  to
                           applicable  withholdings  and in accordance  with the
                           regular payroll practices of the Company; and

                  (b)      continuous coverage, at the Company's expense,  under
                           any group health plan  maintained  by or on behalf of
                           the Company,  in which  Executive  participated as of
                           the Date of  Termination,  for the greater of (i) the
                           twelve  (12)  month  period  following  the  date  of
                           termination,  or  (ii)  the  balance  of the  Term of
                           Employment hereunder; and

                  (c)      continued  participation  in the  Annual  Bonus  Plan
                           referenced  in Section 5.3, on a pro rata basis,  and
                           continued benefits referenced in Attachment 4 to this
                           Agreement,  for the same period as base salary  shall
                           be payable pursuant to Section 7(a).

     Executive's right to continued  coverage under this section shall in no way
reduce or limit any continuation  coverage under such group health plan to which
Executive or any of Executive's  qualified  beneficiaries are entitled under the
provisions  of the  Consolidated  Omnibus  Budget  Reconciliation  Act  of  1985
("COBRA") or Minnesota  Statutes  61A.092 and 62A.17 et seq.  This  extension of
coverage, however, shall be coordinated with, and shall be provided concurrently
with, any benefits or continuation  rights otherwise  available to Executive and
Executive's  eligible dependents under state or federal continuation of coverage
statutes, including but not limited to, Minnesota Statutes 61A.092 and 62A.17 et
seq. and the federal Consolidated  Omnibus Budget  Reconciliation Act ("COBRA").
Accordingly,  within ten (10) days after the date of termination,  Executive and
Executive's  dependents who are eligible for such statutory  continuation rights
shall  complete  all forms and  papers  necessary  and  customary  to elect such
continuation  coverage.  The  Parties  expressly  agree  that the  extension  of
benefits  provided  for by this  Agreement  is not  intended to create a retiree
health plan covering any other employees.  In all other respects, the payment of
benefits, including the amounts and timing thereof, to Executive and Executive's
eligible dependents will be governed by the terms of applicable employee benefit
plans for which Executive and Executive's  dependents are eligible.  The Company
will answer any  reasonable  questions that Executive may have from time to time
and will offer him the same  assistance  given  other  participants  in employee
benefit plans so long as Executive is entitled to benefits as provided herein or
under the terms of those plans.

         Nothing in this Agreement,  including the Severance  Payments described
in this  Section  7,  shall in any way be  construed  to  extend  the  period of
Executive's employment with the Company.

         8.  Confidential  Information.  Except as  permitted or directed by the
Company's  Board of Directors,  during the term of this Agreement or at any time
thereafter Executive shall not divulge,  furnish or make accessible to anyone or
use  in  any  way  (other  than  in the of  the  business  of the  Company)  any
confidential  or secret  knowledge or information of the Company which Executive
has acquired or become acquainted with or will acquire or become acquainted with
prior  to  the  termination  of the  period  of his  employment  by the  Company
(including  employment by the Company or any affiliated  companies  prior to the
date of this agreement),  whether developed by himself or by others,  concerning

<PAGE>

any trade secrets,  confidential or secret designs, processes,  formulae, plans,
devices  or  material  (whether  or not  patented  or  patentable)  directly  or
indirectly useful in any aspect of the business of the Company,  any customer or
supplier  lists of the  Company,  any  confidential  or  secret  development  or
research work of the Company,  or any other  confidential  information or secret
aspects  of the  business  of  the  Company,  Executive  acknowledges  that  the
above-described knowledge or information constitutes a unique and valuable asset
of the Company and represents a substantial  investment.  of time and expense by
the Company and its  predecessors,  and that any disclosure or other use of such
knowledge or information other than for the sole benefit of the Company would be
wrongful and would cause irreparable harm to the Company.  Both during and after
the term of this  agreement,  Executive  will refrain from any acts or omissions
that would reduce the value of such knowledge or information to the Company. The
foregoing  obligations  of  confidentiality,  however,  shall  not  apply to any
knowledge or information  which is now published or which  subsequently  becomes
generally  publicly known in the form in which it was obtained from the Company,
other than as a direct or  indirect  result of the breach of this  agreement  by
Executive.  It is  hereby  acknowledged  that  it is not  the  intention  of the
forgoing  provisions to preclude the Executive from securing gainful  employment
with  subsequent  employers who are not  competitors of the Company or who would
otherwise have no reasonable  commercial use of the above described knowledge or
information,   but  only  to  protect  the  Company's   legitimate   proprietary
information or knowledge.

         9.  Ventures.  If,  during  the term of this  Agreement,  Executive  is
engaged in or  associated  with the  planning or  implementing  of any  project,
program or venture  involving  the Company  and a third  party or  parties,  all
rights in such project,  program or venture shall belong to the Company.  Except
as formally approved by the Company's Board of Directors, Executive shall not be
entitled  to  any  interest  in  such  project,  program  or  venture  or to any
commission,  finder's fee or other  compensation  in connection  therewith other
than the salary or other  compensation  to be paid to  Executive  as provided in
this Agreement.

     10. Noncompetition Covenant.

                  10.1 Agreement Not to Compete.  Executive agrees that,  during
         his Term of Employment with the Company and for a period of twelve (12)
         months  after  the  termination  of  such   employment   (whether  such
         termination  is with or without Cause,  or whether such  termination is
         occasioned  by Executive  or the  Company),  he shall not,  directly or
         indirectly,  engage in  competition  with the  Company in any manner or
         capacity  (e.g., as an advisor,  principal,  agent,  partner,  officer,
         director,  stockholder,  employee,  or  otherwise)  in any phase of the
         business  which  the  Company  is  conducting  during  the term of this
         Agreement.  In  addition,  during this same  twelve  (12) month  period
         following  Executive's Term of Employment,  Executive shall not solicit
         or otherwise encourage any third party or representative  thereof,  who
         was at the end of  Executive's  Term of  Employment,  a customer of the
         Company,  for the  purpose of causing  such  customer or  customers  to
         purchase,  lease or  otherwise  use any  product or service  offered by
         Executive or any organization  with which Executive is affiliated.  Nor
         during this same twelve (12) month  period shall  Executive  solicit or
         otherwise  encourage any employee of the Company to leave the employ of
         the Company for any reason.

          10.2 Geographic Extent of Covenant. The obligations of Executive under
     Section 10.1 shall apply to any geographic area in which the Company:

          (a) has engaged in business during the term of this agreement  through
     production, promotional, sales or marketing activity, or otherwise, or

          (b) has otherwise  established its goodwill,  business reputation,  or
     any customer or supplier relations.

          10.3  Limitation  on Covenant.  Ownership by  Executive,  as a passive
     investment,  of less than five  percent (5%) of the  outstanding  shares of

<PAGE>

     capital  stock of any  corporation  listed on an over-the-counter  market
     or publicly traded in a  national securities exchange shall not constitute
     a breach of this Section 10.

          10.4 Indirect  Competition.  Executive further agrees that, during his
     Term of Employment and within twelve (12) months  thereafter,  he will not,
     directly or  indirectly,  assist or encourage  any other person in carrying
     out,  directly or indirectly,  any activity that would be prohibited by the
     above  provisions  of this Section 10 if such  activity were carried out by
     Executive,  either  directly or  indirectly,  and in  particular  Executive
     agrees that he will not, directly or indirectly, induce any employee of the
     Company to carry out, directly or indirectly, any such activity.

         11.      Patent, Copyrights and Related Matters.

                  11.1  Disclosure  and  Assignment.   Executive  will  promptly
         disclose in writing to the Company complete information concerning each
         and every invention, discovery, improvement, device. design, apparatus,
         practice,  process, method or product, whether patentable or not, made,
         developed,  perfected,  devised, conceived or first reduced to practice
         by Executive, either solely or in collaboration with others, during the
         term of this agreement, or within six months thereafter, whether or not
         during regular working hours,  relating to any phase of the business of
         the  Company  conducted  at  such  time  (hereinafter  referred  to  as
         "Developments").  Executive,  to the extent that he has the legal right
         to do so, hereby acknowledges that any and all of said Developments are
         the property of the Company and hereby  assigns and agrees to assign to
         the Company and all of the Executive's right, title and interest in and
         to any and all of such Developments.

                  11.2 Future  Developments.  As to any future Developments made
         by  Executive  and which are first  conceived  or reduced  to  practice
         during  the  term of  Executive's  employment,  or  within  six  months
         thereafter, but which are claimed for any reason to belong to an entity
         or person other than the Company,  Executive will promptly disclose the
         same in  writing  to the  Company  and shall not  disclose  the same to
         others if the Company, within ninety (90) days thereafter,  shall claim
         ownership of such  Developments  under the terms of this agreement.  If
         the Company  makes such claim,  Executive  agrees that,  insofar as the
         rights  (if any) of  Executive  are  involved,  it will be  settled  by
         arbitration  in accordance  with the rules of the American  Arbitration
         Association.  The  locale  of the  arbitration  shall  be  Minneapolis,
         Minnesota  (or  other  locale  convenient  to the  Company's  principal
         executive  offices).  If the  Company  makes no such  claim,  Executive
         hereby acknowledges that the Company has made no promise to receive and
         hold in confidence any such information disclosed by Executive.

          11.3  Limitation on Sections 11.1 and 11.2. The provisions of sections
     11.1 and 11.2  shall not apply to any  Development  meeting  the  following
     conditions:

          (a) such  Development was developed  entirely on Executive's own time;
     and

          (b)  such  Development  was  made  without  the  use  of  any  Company
     equipment, supplies, facility or trade secret information; and

          (c) such  Development  does not relate (i) directly to the business of
     the Company,  or (ii) to the Company's  actual or demonstrably  anticipated
     research or development.

                  11.4 Executive Assistance.  Executive agrees to assist Company
         in obtaining patents or copyrights on any Developments  assigned to the
         Company that the Company,  in its sole  discretion,  seeks to patent or
         copyright.  Executive  also  agrees  to sign all  documents  and do all

<PAGE>

         things  deemed  necessary  by Company to obtain  and/or  maintain  such
         patents or copyrights,  to assign them to Company,  and to protect them
         against infringement. The obligations of this Section 11 are continuing
         and shall  survive  the  termination  of  Executive's  employment  with
         Company.

                  11.5 Appointment of Agent.  Executive irrevocably appoints the
         Chairman  of the Board of the Company to act as  Executive's  agent and
         attorney  in fact to  perform  all  acts  necessary  to  obtain  and/or
         maintain  patents  or  copyrights  to  any  Developments   assigned  by
         Executive to the Company under this Agreement if (i) Executive  refuses
         to perform those acts or (ii) is unavailable, within the meaning of the
         United States patent and copyright laws.  Executive  acknowledges  that
         the  grant  of the  foregoing  power of  attorney  is  coupled  with an
         interest and shall survive the death or disability of Executive and the
         termination of Executive's employment with the Company,

                  11.6 Notice and  Acknowledgment.  Executive  acknowledges that
         this  section of this  Agreement  does not apply to a  Development  for
         which there was no  equipment,  supplies,  facilities  or trade  secret
         information  of the Company  used and which was  developed  entirely on
         Executive's  own  time,  and  which  does not  relate  directly  to the
         business  of  the  Company  or the  Company's  actual  or  demonstrably
         anticipated research or development,  or which does not result from any
         work performed by Executive for the Company.

         12.      Termination.

          12.1 Grounds for Termination. This agreement shall be terminated under
     the following circumstances:


          (a) By mutual agreement of Executive and the Company;

          (b) Immediately upon the death of Executive;

          (c) Upon  delivery  by  Executive  of a notice of  termination  to the
     Company,  in which event this agreement shall be terminated sixty (60) days
     after receipt of such notice;

          (d) At  Executive's  option,  upon the occurrence of any of the events
     set forth in clauses (ii) through (v) of the first paragraph of Section 7;

          (e) Upon the occurrence of an event constituting "Cause" as defined in
     Section 1.3.

         Notwithstanding  any  termination  of  this  agreement,  Executive,  in
         consideration  of  his  employment   hereunder  to  the  date  of  such
         termination,  shall remain bound by the  provisions  of this  agreement
         which specifically relate to periods, activities or obligations upon or
         subsequent  to the  termination  of  Executive's  employment,  and  the
         Company  shall  remain  bound by the  provisions  of  Section 5 (to the
         extent  that  they  relate  to time  periods  prior to the date of such
         termination),  and  Section 7 except in the case of a  termination  for
         Cause  pursuant  to  Section12.1  (e)  or a  termination  by  Executive
         pursuant to Section 12.1(c).

                  12.2  Surrender of Records and Property.  Upon  termination of
         his employment with the Company,  Executive  shall deliver  promptly to
         the  Company all  records,  manuals,  books,  blank  forms,  documents,
         letters,   memoranda,   notes,   notebooks,   reports,   data,  tables,
         calculations or copies  thereof,  which are the property of the Company
         or which  relate in any way to the  business,  products,  practices  or
         techniques of the Company,  and all other  property,  trade secrets and
         confidential information of the Company, including, but not limited to,
         all  documents  which in whole or in part contain any trade  secrets or
         confidential  information  of the Company;  which in any of these cases
         are in his  possession or under his control.  Provided,  however,  that

<PAGE>

         Executive  shall be  entitled  to retain  items of  sentimental  value,
         copies of which  shall be provided to the Company at the request of the
         Company and at the Company's expense.

         13.      Miscellaneous.

          13.1 Governing Law. This Agreement is made under and shall be governed
     by and construed in accordance with the laws of the State of Minnesota.

          13.2 Prior Agreements. This Agreement contains the entire agreement of
     the parties  relating to the subject matter hereof and supersedes all prior
     agreements and understandings  with respect to such subject matter, and the
     parties  hereto  have made no  agreements,  representations  or  warranties
     relating to the subject  matter of this  agreement  which are not set forth
     herein.

          13.3  Withholding  Taxes.  The Company may  withhold  from all salary,
     bonus,  severance pay or other  benefits  payable under this  agreement all
     federal,  state,  city or other taxes as shall be required  pursuant to any
     law or governmental regulation or ruling.

          13.4 Amendments.  No amendment or modification of this agreement shall
     be deemed  effective  unless  made in  writing  and  signed by the  parties
     hereto.

          13.5 No Waiver. No term or condition of this agreement shall be deemed
     to have been  waived,  nor  shall  there be any  estoppel  to  enforce  any
     provisions of this  agreement,  except by a statement in writing  signed by
     the party whom enforcement of the waiver or estoppel is sought. Any written
     waiver shall not be deemed a continuing waiver unless specifically  stated,
     shall  operate only as to the specific  term or condition  waived and shall
     not  constitute a waiver of such term or condition  for the future or as to
     any act other than specifically waived.

          13.6 Severability. To the extent any provision of this agreement shall
     be invalid or unenforceable,  it shall be considered  deleted here from and
     the remainder of such provision and of this  agreement  shall be unaffected
     and shall  continue in full force and  effect.  In  furtherance  and not in
     limitation of the foregoing, should the duration or geographical extent of,
     or business  activities  covered by, any provision of this  agreement be in
     excess of that which is valid and  enforceable  under  applicable law, then
     such provision  shall be construed to cover only that  duration,  extent or
     activities  which  may  validly  and  enforceably  be  covered.   Executive
     acknowledges  the  uncertainty  of the law in this  respect  and  expressly
     stipulates that this agreement be given the construction  which renders its
     provisions  valid and  enforceable to the maximum extent (not exceeding its
     express terms) possible under applicable law.

          13.7 Assignment.  This agreement shall not be assignable,  in whole or
     in part, by either party without the written consent of the other party.

          13.8 Injunctive Relief. Executive agrees that it would be difficult to
     compensate  the  Company  fully  for  damages  for  any  violation  of  the
     provisions of this agreement,  including without  limitation the provisions
     of Sections 9, 10, 11 and 12.2. Accordingly,  Executive specifically agrees
     that the Company shall be entitled to temporary  and  permanent  injunctive
     relief to enforce the provisions of this agreement and that such relief may
     be granted without the necessity of proving actual damages.  This provision
     with respect to injunctive relief shall not, however, diminish the right of
     the Company to claim and recover damages in addition to injunctive relief.
<PAGE>

MEDTOX SCIENTIFIC, INC.



By______________________                             ___________________________
     Its ___________________                                  Richard J. Braun





                                                                 Exhibit 10.45
                              EMPLOYMENT AGREEMENT

          THIS   AGREEMENT,   dated  January  1,  2000  by  and  between  MEDTOX
Scientific,  Inc., a corporation  (the "Company") and Harry G. McCoy, a resident
of Minnesota ("Executive").

         WHEREAS,  the Company  desires to employ  Executive upon and subject to
the terms and conditions set forth in this agreement,  and Executive  desires to
render services for the Company on such terms and conditions.

         NOW,  THEREFORE,  in  consideration  of the premises and the respective
undertakings  of the  Company and  Executive  set forth  below,  the Company and
Executive agree as follows:

          1 .  Definitions.  The  following  defined  terms have the  respective
     meanings described below:


          1.1 Change in Control. A "Change in Control" of the Company shall mean
     any of the following:


          (a) a change in  control  of a nature  that  would be  required  to be
     reported  in  response  to Item  6(c) of  Schedule  14A of  Regulation  14A
     promulgated  under the  Securities  Exchange  Act of 1934,  as amended (the
     "Exchange  Act"),  whether  or not  the  Company  is then  subject  to such
     reporting requirement; or

          (b) a merger  or  consolidation  to which the  Company  is a party if,
     following  the  effective  date  of  such  merger  or  consolidation,   the
     individuals and entities who were  shareholders of the Company prior to the
     effective date of such merger or  consolidation  have beneficial  ownership
     (as  defined  in Rule  13d-3  under the  Exchange  Act) of less than  fifty
     percent  (50%) of the combined  voting power of the  surviving  corporation
     following the effective date of such merger or consolidation; or

          (c) when,  during any period of twenty-four  (24)  consecutive  months
     during the term of this Agreement, the individuals who, at the beginning of
     such period, constitute the Board (the "Incumbent Directors") cease for any
     reason  other  than  death  to  constitute  at  least a  majority  thereof,
     provided,  however, that a director who was not a director at the beginning
     of such  twenty-four  (24) month period  shall be deemed to have  satisfied
     such twenty-four (24) month requirement,  and be an Incumbent Director,  if
     such  director  was  elected  by, or on the  recommendation  of or with the
     approval of, at least  two-thirds of the  directors  who then  qualified as
     Incumbent  Directors  either  actually,  because they were directors at the
     beginning of such twenty-four  (24) month period,  or by prior operation of
     this Section.

          1.2 Potential  Change in Control.  A "Potential  Change in Control" of
     the Company shall be deemed to have occurred if:


<PAGE>

          (a) the Company enters into an agreement,  the  consummation  of which
     would result in the occurrence of a Change in Control;

          (b) any person (including the Company) publicly announces an intention
     to take or to consider taking actions which if consummated would constitute
     a Change in Control;

          (c) any person becomes the beneficial  owner,  directly or indirectly,
     of securities of the Company  representing ten percent (10%) or more of the
     combined voting power of the Company's then outstanding securities; or

          (d) the Board adopts a resolution to the effect that, for the purposes
     of this  Agreement,  a  "Potential  Change in  Control"  of the Company has
     occurred.

     1.3 Cause.  Termination  by the Company of the  Executive's  employment for
"Cause" shall mean termination upon:

     (a) the willful and  continued  failure by the  Executive to  substantially
perform an  Executive's  duties  with the Company  (other than any such  failure
resulting from Executive's incapacity due to physical or mental illness) after a
written demand for substantial  performance is delivered to the Executive by the
Company's Board of Directors, which demand specifically identifies the manner in
which the  Company  believes  that  Executive  has not  substantially  performed
Executive's duties; or

     (b) the willful  engaging by the Executive in conduct which is demonstrably
and materially injurious to the Company, monetarily or otherwise.

     For  purposes  of this  Section  1.3,  no act,  or failure  to act,  on the
Executive's  part shall be deemed  "willful" unless done, or omitted to be done,
by the  Executive  not in good  faith and  without  reasonable  belief  that the
Executive's action or omission was in the best interest of the Company.

     1.4  Company.  The term  "Company"  means MEDTOX  Scientific.  Inc. and any
successors and assigns of the Company.

     2.  Employment.  The Company  hereby  employs  Executive as  President  and
Chairman  of the Board,  and  Executive  acepts  such  employment  and agrees to
perform  services for the  Company,  for the period and upon the other terms and
conditions set forth in this agreement.

     3. Term of Employment.  The term of Executive's employment hereunder ("Term
of Employment") shall commence on the date hereof and shall continue for a three
year period ending on December 31, 2002 (unless earlier terminated in accordance
with the  provisions  of Section 13 of this  agreement).  The Term of Employment
shall be automatically extended by successive 12-month terms thereafter.

     4. Position and Duties

          4.1 Service with  Company.  During his Term of  Employment,  Executive
     agrees to perform such reasonable  employment  duties,  consistent with the

<PAGE>

     terms of this  agreement,  as the Board of Directors  of the Company  shall
     assign   to  him  from   time  to  time,   Such   duties   and   employment
     responsibilities shall be performed in accordance with the Company's rules,
     regulations  and  instructions  now in force or which may be adopted by the
     Company in the future. During the Executive's Term of Employment, the Board
     of Directors shall nominate and recommend to shareholders  the election of,
     and vote all shareholder  proxies in favor of, Executive's  election to the
     Company's Board of Directors.

     4.2  Performance of Duties.  During his Term of  Employment,  the Executive
agrees to serve the  Company  exclusively  and to the best of his  ability.  The
Executive  shall have active  involvement and be fully committed to the business
and affairs of the Company, and shall devote one hundred percent of his business
time to the affairs of the Company,  except for (i) vacations and excused leaves
of absence as permitted in accordance with Company  policy;  (ii) service on the
Boards of Directors of other  companies at the discretion of the Company's Board
of  Directors;  (iii)  service  on the  Boards of  Directors  of  not-for-profit
entities  without  approval  of the  Company's  Board of  Directors;  and (iv) a
reasonable  amount  of time  during  the  business  day to handle  his  personal
affairs.  Executive hereby confirms that he is under no contractual  commitments
inconsistent  with his  obligations  set forth in this agreement and that during
his Term of Employment, except as provided herein, he will not render or perform
services for any other corporation,  fin-n, entity or person, nor will he become
involved in the  operations or management of any other  commercial  corporation,
firm, entity or person.

     5. Compensation.

          5.1 Base  Salary.  Initial  base  compensation  for all services to be
     rendered  by  the  Executive  under  this  agreement  during  the  Term  of
     Employment,  the Company  shall pay to  Executive  an annual base salary of
     $225,000  per  year,  which  salary  shall be paid in  accordance  with the
     Company's normal payroll procedures and policies.

          5.2 Annual Bonus Plan. Executive shall participate in the Annual Bonus
     Plan of the Company set forth in Attachment 2 to this Agreement.

          5.3  Performance  Unit  Plan.   Executive  shall  participate  in  the
     Performance  Unit Plan of the  Company  set forth in  Attachment  3 to this
     Agreement.

          5.4 Benefits.  Executive  shall be entitled to such  Company-sponsored
     benefits as are provided to executive employees of the Company,  subject to
     the terms and conditions of the applicable policies and/or plans. Executive
     shall  be  entitled  to the  specific  additional  benefits  enumerated  in
     Attachment 4 to this Agreement.

          5.5  Restricted  Stock.  Executive  shall be  entitled  to  grants  of
     restricted stock as provided in Attachment 5 of this Agreement.

         6. Executive's Agreement to Continue Employment for Six (6) Months. The
Executive agrees that, subject to the terms and conditions of this Agreement, in
the event of a Potential  Change in Control of the Company  occurring during the
Term of Employment, if so requested by the Company, Executive will remain in the
employ of the Company  for a period of six (6) months  after the  occurrence  of
such  Potential  Change in Control of the Company.  If more than one  "Potential
Change in Control" occurs during the Term of Employment,  the provisions of this
Section 6 shall be applicable to each  "Potential  Change of Control"  occurring
prior to the occurrence of a Change in Control.

         7. Severance Payments. If during the Term of Employment, (i) whether or
not a Change in Control or Potential Change in Control has occurred, the Company
terminates  the employment of Executive  other than for Cause,  (ii) a Change in
Control  has  occurred  and  Executive  has  complied  with  Section  6 of  this

<PAGE>

Agreement,  or (iii)  the  Executive's  duties,  responsibilities  or  authority
(including status, office, title, reporting relationships or working conditions)
have been materially altered from those in effect on the date of this Agreement,
(iv) the Executive has been required to relocate to an office or related  entity
more than fifty (50) miles from the office  where  Executive  was located on the
date hereof,  or (v) the Company has breached any of its obligations  under this
Agreement, then, in any such event (at the Executive's option in the case of any
event described in clause (ii) through (v) above),  the  Executive's  employment
hereunder shall cease and Executive shall be entitled to the following benefits:

                  (a)      the Company  will pay to  Executive  the  Executive's
                           then  current  base salary for the greater of (i) the
                           twelve (12) month period  following  the date of such
                           termination,  or  (ii)  the  balance  of the  Term of
                           Employment  hereunder,  in  either  case  subject  to
                           applicable  withholdings  and in accordance  with the
                           regular payroll practices of the Company; and

                  (b)      continuous coverage, at the Company's expense,  under
                           any group health plan  maintained  by or on behalf of
                           the Company,  in which  Executive  participated as of
                           the Date of  Termination,  for the greater of (i) the
                           twelve  (12)  month  period  following  the  date  of
                           termination,  or  (ii)  the  balance  of the  Term of
                           Employment hereunder; and

                  (c)      continued  participation  in the  Annual  Bonus  Plan
                           referenced  in Section 5.3, on a pro rata basis,  and
                           continued benefits referenced in Attachment 4 to this
                           Agreement,  for the same period as base salary  shall
                           be payable pursuant to Section 7(a).

     Executive's right to continued  coverage under this section shall in no way
reduce or limit any continuation  coverage under such group health plan to which
Executive or any of Executive's  qualified  beneficiaries are entitled under the
provisions  of the  Consolidated  Omnibus  Budget  Reconciliation  Act  of  1985
("COBRA") or Minnesota  Statutes  61A.092 and 62A.17 et seq.  This  extension of
coverage, however, shall be coordinated with, and shall be provided concurrently
with, any benefits or continuation  rights otherwise  available to Executive and
Executive's  eligible dependents under state or federal continuation of coverage
statutes, including but not limited to, Minnesota Statutes 61A.092 and 62A.17 et
seq. and the federal Consolidated  Omnibus Budget  Reconciliation Act ("COBRA").
Accordingly,  within ten (10) days after the date of termination,  Executive and
Executive's  dependents who are eligible for such statutory  continuation rights
shall  complete  all forms and  papers  necessary  and  customary  to elect such
continuation  coverage.  The  Parties  expressly  agree  that the  extension  of
benefits  provided  for by this  Agreement  is not  intended to create a retiree
health plan covering any other employees.  In all other respects, the payment of
benefits, including the amounts and timing thereof, to Executive and Executive's
eligible dependents will be governed by the terms of applicable employee benefit
plans for which Executive and Executive's  dependents are eligible.  The Company
will answer any  reasonable  questions that Executive may have from time to time
and will offer him the same  assistance  given  other  participants  in employee
benefit plans so long as Executive is entitled to benefits as provided herein or
under the terms of those plans.

         Nothing in this Agreement,  including the Severance  Payments described
in this  Section  7,  shall in any way be  construed  to  extend  the  period of
Executive's employment with the Company.

         8.  Confidential  Information.  Except as  permitted or directed by the
Company's  Board of Directors,  during the term of this Agreement or at any time
thereafter Executive shall not divulge,  furnish or make accessible to anyone or
use  in  any  way  (other  than  in the of  the  business  of the  Company)  any
confidential  or secret  knowledge or information of the Company which Executive
has acquired or become acquainted with or will acquire or become acquainted with
prior  to  the  termination  of the  period  of his  employment  by the  Company
(including  employment by the Company or any affiliated  companies  prior to the
date of this agreement),  whether developed by himself or by others,  concerning
any trade secrets,  confidential or secret designs, processes,  formulae, plans,
devices  or  material  (whether  or not  patented  or  patentable)  directly  or

<PAGE>

indirectly useful in any aspect of the business of the Company,  any customer or
supplier  lists of the  Company,  any  confidential  or  secret  development  or
research work of the Company,  or any other  confidential  information or secret
aspects  of the  business  of  the  Company,  Executive  acknowledges  that  the
above-described knowledge or information constitutes a unique and valuable asset
of the Company and represents a substantial  investment.  of time and expense by
the Company and its  predecessors,  and that any disclosure or other use of such
knowledge or information other than for the sole benefit of the Company would be
wrongful and would cause irreparable harm to the Company.  Both during and after
the term of this  agreement,  Executive  will refrain from any acts or omissions
that would reduce the value of such knowledge or information to the Company. The
foregoing  obligations  of  confidentiality,  however,  shall  not  apply to any
knowledge or information  which is now published or which  subsequently  becomes
generally  publicly known in the form in which it was obtained from the Company,
other than as a direct or  indirect  result of the breach of this  agreement  by
Executive.  It is  hereby  acknowledged  that  it is not  the  intention  of the
forgoing  provisions to preclude the Executive from securing gainful  employment
with  subsequent  employers who are not  competitors of the Company or who would
otherwise have no reasonable  commercial use of the above described knowledge or
information,   but  only  to  protect  the  Company's   legitimate   proprietary
information or knowledge.

         9.  Ventures.  If,  during  the term of this  Agreement,  Executive  is
engaged in or  associated  with the  planning or  implementing  of any  project,
program or venture  involving  the Company  and a third  party or  parties,  all
rights in such project,  program or venture shall belong to the Company.  Except
as formally approved by the Company's Board of Directors, Executive shall not be
entitled  to  any  interest  in  such  project,  program  or  venture  or to any
commission,  finder's fee or other  compensation  in connection  therewith other
than the salary or other  compensation  to be paid to  Executive  as provided in
this Agreement.

 10.      Noncompetition Covenant.

          10.1 Agreement Not to Compete.  Executive agrees that, during his Term
     of Employment with the Company and for a period of twelve (12) months after
     the  termination of such  employment  (whether such  termination is with or
     without  Cause,  or whether such  termination is occasioned by Executive or
     the Company),  he shall not, directly or indirectly,  engage in competition
     with the Company in any manner or capacity (e.g., as an advisor, principal,
     agent, partner, officer, director, stockholder,  employee, or otherwise) in
     any phase of the business  which the Company is conducting  during the term
     of this Agreement.  In addition,  during this same twelve (12) month period
     following  Executive's  Term of Employment,  Executive shall not solicit or
     otherwise encourage any third party or representative  thereof,  who was at
     the end of Executive's Term of Employment,  a customer of the Company,  for
     the purpose of causing such  customer or  customers  to purchase,  lease or
     otherwise  use  any  product  or  service   offered  by  Executive  or  any
     organization  with which  Executive  is  affiliated.  Nor during  this same
     twelve (12) month period shall Executive solicit or otherwise encourage any
     employee of the Company to leave the employ of the Company for any reason.

          10.2 Geographic Extent of Covenant. The obligations of Executive under
     Section 10.1 shall apply to any geographic  area in which the Company:

               (a) has  engaged in  business  during the term of this  agreement
          through  production,  promotional,  sales or  marketing  activity,  or
          otherwise, or

               (b) has otherwise established its goodwill,  business reputation,
          or any customer or supplier relations.

               10.3 Limitation on Covenant. Ownership by Executive, as a passive
          investment,  of less than five percent (5%) of the outstanding  shares
          of capital  stock of any  corporation  listed on an over-the-counter
          market or publicly traded in a national  securities exchange shall
          not constitute a breach of this Section 10.
<PAGE>

               10.4 Indirect Competition.  Executive further agrees that, during
          his Term of Employment  and within twelve (12) months  thereafter,  he
          will not, directly or indirectly, assist or encourage any other person
          in carrying out,  directly or  indirectly,  any activity that would be
          prohibited by the above provisions of this Section 10 if such activity
          were carried out by Executive,  either directly or indirectly,  and in
          particular  Executive agrees that he will not, directly or indirectly,
          induce  any  employee  of  the  Company  to  carry  out,  directly  or
          indirectly, any such activity.

      11.      Patent, Copyrights and Related Matters.

               11.1 Disclosure and Assignment.  Executive will promptly disclose
          in writing to the Company  complete  information  concerning  each and
          every invention,  discovery,  improvement,  device. design, apparatus,
          practice, process, method or product, whether patentable or not, made,
          developed,  perfected, devised, conceived or first reduced to practice
          by Executive,  either solely or in collaboration  with others,  during
          the term of this agreement,  or within six months thereafter,  whether
          or not during  regular  working  hours,  relating  to any phase of the
          business of the Company conducted at such time  (hereinafter  referred
          to as "Developments").  Executive, to the extent that he has the legal
          right  to do  so,  hereby  acknowledges  that  any  and  all  of  said
          Developments  are the  property of the Company and hereby  assigns and
          agrees to  assign to the  Company  and all of the  Executive's  right,
          title and interest in and to any and all of such Developments.

               11.2 Future  Developments.  As to any future Developments made by
          Executive and which are first  conceived or reduced to practice during
          the term of Executive's  employment,  or within six months thereafter,
          but which are  claimed for any reason to belong to an entity or person
          other than the Company,  Executive will promptly  disclose the same in
          writing to the  Company and shall not  disclose  the same to others if
          the Company, within ninety (90) days thereafter, shall claim ownership
          of such Developments under the terms of this agreement. If the Company
          makes such claim,  Executive  agrees  that,  insofar as the rights (if
          any) of Executive are involved,  it will be settled by  arbitration in
          accordance with the rules of the American Arbitration Association. The
          locale of the arbitration  shall be  Minneapolis,  Minnesota (or other
          locale convenient to the Company's principal  executive  offices).  If
          the Company makes no such claim,  Executive hereby  acknowledges  that
          the Company has made no promise to receive and hold in confidence  any
          such information disclosed by Executive.

               11.3  Limitation  on Sections  11.1 and 11.2.  The  provisions of
          sections 11.1 and 11.2 shall not apply to any Development  meeting the
          following conditions:

                    (a) such  Development was developed  entirely on Executive's
               own time; and

                    (b) such Development was made without the use of any Company
               equipment, supplies, facility or trade secret information; and

                    (c) such  Development  does not relate (i)  directly  to the
               business  of the  Company,  or (ii) to the  Company's  actual  or
               demonstrably anticipated research or development.

          11.4  Executive  Assistance.  Executive  agrees to assist  Company  in
     obtaining patents or copyrights on any Developments assigned to the Company
     that the Company,  in its sole  discretion,  seeks to patent or  copyright.
     Executive  also  agrees  to sign all  documents  and do all  things  deemed
     necessary by Company to obtain and/or  maintain such patents or copyrights,
     to assign them to Company,  and to protect them against  infringement.  The

<PAGE>

     obligations  of this  Section  11 are  continuing  and  shall  survive  the
     termination of Executive's employment with Company.

          11.5 Appointment of Agent. Executive irrevocably appoints the Chairman
     of the Board of the  Company to act as  Executive's  agent and  attorney in
     fact to perform all acts  necessary to obtain  and/or  maintain  patents or
     copyrights to any  Developments  assigned by Executive to the Company under
     this  Agreement if (i)  Executive  refuses to perform those acts or (ii) is
     unavailable,  within the meaning of the United  States patent and copyright
     laws.  Executive  acknowledges  that the  grant of the  foregoing  power of
     attorney  is  coupled  with an  interest  and  shall  survive  the death or
     disability of Executive and the termination of Executive's  employment with
     the Company,

          11.6  Notice  and  Acknowledgment.  Executive  acknowledges  that this
     section of this Agreement  does not apply to a Development  for which there
     was no equipment,  supplies,  facilities or trade secret information of the
     Company used and which was developed  entirely on Executive's own time, and
     which  does not  relate  directly  to the  business  of the  Company or the
     Company's actual or demonstrably  anticipated  research or development,  or
     which does not result from any work performed by Executive for the Company.

   12. Termination.

          12.1 Grounds for Termination. This agreement shall be terminated under
     the following circumstances:


               (a) By mutual agreement of Executive and the Company;

               (b) Immediately upon the death of Executive;

               (c) Upon delivery by Executive of a notice of  termination to the
          Company,  in which event this agreement shall be terminated sixty (60)
          days after receipt of such notice;

               (d) At  Executive's  option,  upon the  occurrence  of any of the
          events set forth in clauses (ii) through (v) of the first paragraph of
          Section 7;

               (e)  Upon the  occurrence  of an event  constituting  "Cause"  as
          defined in Section 1.3.

         Notwithstanding  any  termination  of  this  agreement,  Executive,  in
         consideration  of  his  employment   hereunder  to  the  date  of  such
         termination,  shall remain bound by the  provisions  of this  agreement
         which specifically relate to periods, activities or obligations upon or
         subsequent  to the  termination  of  Executive's  employment,  and  the
         Company  shall  remain  bound by the  provisions  of  Section 5 (to the
         extent  that  they  relate  to time  periods  prior to the date of such
         termination),  and  Section 7 except in the case of a  termination  for
         Cause  pursuant  to  Section12.1  (e)  or a  termination  by  Executive
         pursuant to Section 12.1(c).

                  12.2  Surrender of Records and Property.  Upon  termination of
         his employment with the Company,  Executive  shall deliver  promptly to
         the  Company all  records,  manuals,  books,  blank  forms,  documents,
         letters,   memoranda,   notes,   notebooks,   reports,   data,  tables,
         calculations or copies  thereof,  which are the property of the Company
         or which  relate in any way to the  business,  products,  practices  or
         techniques of the Company,  and all other  property,  trade secrets and
         confidential information of the Company, including, but not limited to,
         all  documents  which in whole or in part contain any trade  secrets or
         confidential  information  of the Company;  which in any of these cases
         are in his  possession or under his control.  Provided,  however,  that
         Executive  shall be  entitled  to retain  items of  sentimental  value,

<PAGE>

         copies of which  shall be provided to the Company at the request of the
         Company and at the Company's expense.

         13.      Miscellaneous.

               13.1  Governing  Law.  This  Agreement is made under and shall be
          governed by and construed in accordance  with the laws of the State of
          Minnesota.

               13.2  Prior  Agreements.   This  Agreement  contains  the  entire
          agreement  of the parties  relating to the subject  matter  hereof and
          supersedes  all prior  agreements and  understandings  with respect to
          such subject  matter,  and the parties hereto have made no agreements,
          representations  or warranties  relating to the subject matter of this
          agreement which are not set forth herein.

               13.3 Withholding Taxes. The Company may withhold from all salary,
          bonus,  severance pay or other  benefits  payable under this agreement
          all federal,  state, city or other taxes as shall be required pursuant
          to any law or governmental regulation or ruling.

               13.4  Amendments.  No amendment or modification of this agreement
          shall be deemed  effective  unless  made in writing  and signed by the
          parties hereto.

               13.5 No Waiver.  No term or condition of this agreement  shall be
          deemed to have been waived, nor shall there be any estoppel to enforce
          any  provisions  of this  agreement,  except by a statement in writing
          signed by the party  whom  enforcement  of the waiver or  estoppel  is
          sought.  Any written  waiver shall not be deemed a  continuing  waiver
          unless specifically stated, shall operate only as to the specific term
          or condition  waived and shall not constitute a waiver of such term or
          condition  for the  future  or as to any act other  than  specifically
          waived.

               13.6 Severability.  To the extent any provision of this agreement
          shall be invalid or unenforceable, it shall be considered deleted here
          from and the remainder of such provision and of this  agreement  shall
          be  unaffected  and  shall  continue  in full  force  and  effect.  In
          furtherance  and  not in  limitation  of  the  foregoing,  should  the
          duration or geographical extent of, or business activities covered by,
          any  provision  of this  agreement be in excess of that which is valid
          and  enforceable  under  applicable  law, then such provision shall be
          construed to cover only that duration,  extent or activities which may
          validly  and  enforceably  be  covered.   Executive  acknowledges  the
          uncertainty of the law in this respect and expressly  stipulates  that
          this agreement be given the construction  which renders its provisions
          valid and enforceable to the maximum extent (not exceeding its express
          terms) possible under applicable law.

               13.7 Assignment. This agreement shall not be assignable, in whole
          or in part, by either party  without the written  consent of the other
          party.

                  13.8  Injunctive  Relief.  Executive  agrees  that it would be
         difficult to compensate the Company fully for damages for any violation
         of the provisions of this agreement,  including without  limitation the
         provisions  of  Sections  9, 10,  11 and 12.2.  Accordingly,  Executive
         specifically agrees that the Company shall be entitled to temporary and
         permanent injunctive relief to enforce the provisions of this agreement
         and that such relief may be granted  without the  necessity  of proving
         actual damages.  This provision with respect to injunctive relief shall
         not,  however,  diminish  the right of the Company to claim and recover
         damages in addition to injunctive relief.
<PAGE>

MEDTOX SCIENTIFIC, INC.



By______________________                             ___________________________
     Its ___________________                                  Harry G. McCoy





                                                               Exhibit 24.1



                          INDEPENDENT AUDITORS' CONSENT

We consent to the  incorporation  by reference in  Registration  Statements  No.
333-45057 on Form S-3 dated  February 4, 1988,  No.  333-28783 on Form S-3 dated
October 8, 1997, No. 333-24371 on Form S-8 dated April 2, 1997, No. 333-18547 on
Form S-3 dated  February 14, 1997,  No.  333-827 on Form S-3 dated May 15, 1996,
No. 33-89646 on Form S-8 dated February 21, 1995, No. 33-91840 on Form S-3 dated
July 21, 1995, No. 33-86744 on Form S-3 dated December 13, 1994, No. 33-78590 on
Form S-3 dated June 20, 1994,  No.  33-74078 on Form S-3 dated February 2, 1994,
No. 33-71490 on Form S-8 dated November 11, 1993, No. 33-71596 on Form S-8 dated
November 11, 1993, No. 33-49474 on Form S-8 dated July 10, 1992, No. 33-48566 on
Form S-3 dated June 25, 1992, No.  33-15025 on Form S-8 dated June 29, 1987, and
No.  33-10393 on Form S-8 dated  December 16, 1986 of our report dated  February
18, 2000, with respect to the consolidated  financial statements and schedule of
MEDTOX  Scientific,  Inc.  (formerly EDITEK,  Inc.) as of and for the year ended
December  31, 1999  included  in this Annual  Report (on Form 10-K) for the year
ended December 31, 1999.


/s/ Deloitte & Touche LLP

Minneapolis, Minnesota
March 27, 2000



                                                                   Exhibit 24.2





                         Consent of Independent Auditors

We consent to the  incorporation  by reference in  Registration  Statements  No.
333-45057 on Form S-3 dated  February 4, 1998,  No.  333-28783 on Form S-3 dated
October 8, 1997, No. 333-24371 on Form S-8 dated April 2, 1997, No. 333-18547 on
Form S-3 dated  February 14, 1997,  No.  333-827 on Form S-3 dated May 15, 1996,
No. 33-89646 on Form S-8 dated February 21, 1995, No. 33-91840 on Form S-3 dated
July 21, 1995, No. 33-86744 on Form S-3 dated December 13, 1994, No. 33-78590 on
Form S-3 dated June 20, 1994,  No.  33-74078 on Form S-3 dated February 2, 1994,
No. 33-71490 on Form S-8 dated November 11, 1993, No. 33-71596 on Form S-8 dated
November 11, 1993, No. 33-49474 on Form S-8 dated July 10, 1992, No. 33-48566 on
Form S-3 dated June 25, 1992,  No.  33-15025 on Form S-8 dated June 29, 1987 and
No. 33-10393 on Form S-8 dated December 16, 1986 of our report dated February 6,
1998,  with respect to the  consolidated  financial  statements  and schedule of
Medtox Scientific,  Inc.  (formerly EDITEK,  Inc.) included in the Annual Report
(Form 10-K) for the year ended December 31, 1998.


                                                       /s/ Ernst & Young LLP

Minneapolis, Minnesota
March 27, 2000



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