MACROCHEM CORP
8-K, 2000-10-31
PHARMACEUTICAL PREPARATIONS
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                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                    FORM 8-K

                                 CURRENT REPORT

                     PURSUANT TO SECTION 13 OR 15(D) OF THE
                         SECURITIES EXCHANGE ACT OF 1934



DATE OF REPORT (DATE OF EARLIEST EVENT REPORTED):  OCTOBER 23, 2000



                              MACROCHEM CORPORATION
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             (EXACT NAME OF REGISTRANT AS SPECIFIED IN ITS CHARTER)




         Delaware                        0-13634                 04-2744744

(STATE OR OTHER JURISDICTION           (COMMISSION             (IRS EMPLOYER
    OF INCORPORATION)                  FILE NUMBER)          IDENTIFICATION NO.)



            110 Hartwell Avenue, Lexington, Massachusetts 02421-3134
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               (ADDRESS OF PRINCIPAL EXECUTIVE OFFICES) (ZIP CODE)



REGISTRANT'S TELEPHONE NUMBER:        (781) 862-4003
                              ------------------------------------



                                       N/A
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          (FORMER NAME OR FORMER ADDRESS, IF CHANGED SINCE LAST REPORT)


<PAGE>
ITEM 5.    OTHER EVENTS

         On October 23, 2000,  pursuant to a Securities  Purchase Agreement with
Bay Harbor Investments,  Inc. and Strong River Investments,  Inc. (collectively,
the "Purchasers"),  MacroChem Corporation (the "Company") sold to the Purchasers
1,816,658  shares (the "Shares") of the Company's Common Stock for $9.0 million,
or $4.954152 per share, and issued Closing  Warrants and Adjustable  Warrants to
the Purchasers.  The Closing  Warrants have a five-year term and are exercisable
for an  aggregate  of 363,332  shares of Common  Stock at $5.90 per  share.  The
Adjustable  Warrants,  exercisable at $.01 per share, cover an adjustable amount
of shares of Common Stock,  based on the market price of the Common Stock during
four (4) separate periods of twenty trading days ending up to 240 days following
effectiveness  of the  registration  statement to be filed for the resale of the
Shares and the Common Stock  issuable upon exercise of the Closing  Warrants and
the Adjustable  Warrants (the  "Registration  Statement").  The Purchasers  have
certain  rights of first  refusal and other rights  during the same period.  The
Company may require the Purchasers to purchase an additional $7 million  dollars
of Common Stock seven months after effectiveness of the Registration  Statement,
subject to certain  conditions,  at 105% of the average closing bid price of the
Common  Stock for the five trading  days prior to the  closing.  The  Purchasers
would also receive Closing  Warrants for 20% of the shares sold,  exercisable at
125% of the five-day  average closing bid price,  and Adjustable  Warrants.  The
Company has also issued to Leerink Swann & Company, as partial  compensation for
Leerink  Swann's  services as finder in the  transaction,  a  five-year  warrant
exercisable for 108,999 shares at $7.43 per share.

         The above  summary is not  intended to be complete  and is qualified in
its entirety by reference to the detailed provisions in the agreements which are
attached as exhibits.  In addition,  a copy of the press  release  issued by the
Company in connection with the Transaction is attached hereto as Exhibit 99.1 to
this Form 8-K and is incorporated herein by reference.

ITEM 7.  FINANCIAL STATEMENTS, PRO FORMA FINANCIAL INFORMATION AND EXHIBITS.

(C)      EXHIBITS:


         10.1.     Securities Purchase  Agreement  among MacroChem  Corporation,
                   Bay Harbor Investments,  Inc. and Strong River Investments,
                   Inc. dated as of October 23, 2000.

         10.2.     Form of Closing Warrant dated as of October 23, 2000.

         10.3.     Form of Adjustable Warrant dated as of October 23, 2000.

         10.4.     Form of Registration  Rights Agreement by and among MacroChem
                   Corporation,  Bay Harbor  Investments,  Inc. and Strong River
                   Investments, Inc. dated as of October 23, 2000.

         10.5.     Warrant issued to Leerink Swann & Company dated as of October
                   23, 2000.

         99.1.     Press Release.



<PAGE>
                                    SIGNATURE


         Pursuant to the  requirements  of the Securities  Exchange Act of 1934,
the  registrant  has duly  caused  this report to be signed on its behalf by the
undersigned hereunto duly authorized.

                                                 MacroChem Corporation


Date:  October 31, 2000                     By:/s/Kenneth L. Rice, Jr.
                                            Name:  Kenneth L. Rice, Jr.
                                            Title: Vice President and Treasurer



<PAGE>
                                  EXHIBIT INDEX


         The following designated exhibits are filed herewith:


         10.1.     Securities  Purchase  Agreement among MacroChem  Corporation,
                   Bay Harbor  Investments,  Inc. and Strong River  Investments,
                   Inc. dated as of October 23, 2000.

         10.2.     Form of Closing Warrant dated as of October 23, 2000.

         10.3.     Form of Adjustable Warrant dated as of October 23, 2000.

         10.4.     Form of Registration  Rights Agreement by and among MacroChem
                   Corporation,  Bay Harbor  Investments,  Inc. and Strong River
                   Investments, Inc. dated as of October 23, 2000.

         10.5.     Warrant issued to Leerink Swann & Company dated as of October
                   23, 2000.

         99.       Press Release.


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