MACROCHEM CORP
8-K, EX-10, 2000-10-31
PHARMACEUTICAL PREPARATIONS
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                          SECURITIES PURCHASE AGREEMENT

                                      Among

                              MACROCHEM CORPORATION

                                       and

                         THE INVESTORS SIGNATORY HERETO




                          Dated as of October 23, 2000



<PAGE>
         SECURITIES PURCHASE AGREEMENT (this  "Agreement"),  dated as of October
23, 2000, among MacroChem  Corporation,  a Delaware corporation (the "Company"),
and the investors  signatory hereto (each such investor is a "Purchaser" and all
such investors are, collectively, the "Purchasers").

         WHEREAS,  subject  to the  terms  and  conditions  set  forth  in  this
Agreement,  the  Company  desires  to issue and sell to the  Purchasers  and the
Purchasers,  severally  and not  jointly,  desire to purchase  from the Company,
shares of the  Company's  common  stock,  $.01 par value per share (the  "Common
Stock"),  and certain other securities of the Company as more fully described in
this Agreement.

         NOW,  THEREFORE,  IN CONSIDERATION of the mutual covenants contained in
this Agreement,  and for other good and valuable  consideration  the receipt and
adequacy  are hereby  acknowledged,  the  Company  and the  Purchasers  agree as
follows:


                                    ARTICLE I
                                PURCHASE AND SALE

         1.1      THE CLOSING.


                  (a) THE CLOSING.  (i) Subject to the terms and  conditions set
forth in this Agreement,  the Company shall issue and sell to the Purchasers and
the  Purchasers  shall,  severally  and not  jointly,  purchase an  aggregate of
1,816,658 shares of Common Stock (the "Shares") for an aggregate  purchase price
of $9,000,000 ($4.954152 per share (the "Per Share Price")).  The closing of the
purchase and sale of the Shares (the "Closing")  shall take place at the offices
of Morse,  Zelnick,  Rose & Lander LLP ("MZRL"),  450 Park Avenue, New York, New
York 10022, immediately following the execution hereof or such later date as the
parties shall agree.  The date of the Closing is hereinafter  referred to as the
"Closing Date."

                              (ii) At the Closing,  the parties shall deliver or
 shall cause to be delivered  the  following:  (A) the Company  shall deliver to
 each  Purchaser  (1) a stock  certificate  representing  the  number  of Shares
 indicated below such  Purchaser's name on the signature page of this Agreement,
 registered in the name of such Purchaser,  (2) a Common Stock purchase warrant,
 in the form of Exhibit A, registered in the name of such Purchaser, pursuant to
 which such  Purchaser  shall have the right to acquire  shares of Common  Stock
 upon the terms and in such  number as set forth  therein  (each an  "Adjustable
 Warrant"),  (3) a Common  Stock  purchase  warrant,  in the form of  Exhibit B,
 registered  in the name of such  Purchaser,  pursuant  to which such  Purchaser
 shall have the right to acquire the number of shares of Common Stock  indicated
 below such Purchaser's  name on the signature page of this Agreement,  upon the
 terms and at the exercise price set forth therein  (each,  a "Closing  Warrant"
 and together  with the  Adjustable  Warrants,  the  "Warrants"),  (4) the legal
 opinion of Ropes & Gray,  outside counsel to the Company,  substantially in the
 form of Exhibit C, (5) an executed  Registration  Rights  Agreement,  dated the
 date  hereof,  among the Company and the  Purchasers,  in the form of Exhibit D
 (the "Registration  Rights Agreement") and (6) the Transfer Agent Instructions,
 in the  form of  Exhibit  E,  executed  by the  Company  and  delivered  to and
 acknowledged   by  the   Company's   transfer   agent  (the   "Transfer   Agent
 Instructions");  and (B) each Purchaser  shall deliver:  (1) the purchase price
 indicated below such  Purchaser's  name on the signature page to this Agreement
 in  immediately  available  funds by wire transfer to an account  designated in
 writing by the Company for such purpose and (2) an executed Registration Rights
 Agreement.

         1.2  CERTAIN  DEFINED  TERMS.  For  purposes  of  this  Agreement,  (i)
"Business Day" means any day except Saturday,  Sunday and any day which shall be
a  federal  legal  holiday  in  the  United  States  or a day on  which  banking
institutions in the State of New York are authorized or required by law or other
governmental  action  to close;  (ii)  "Per  Share  Market  Value"  means on any
particular  date (a) the closing bid price per share of the Common Stock on such
date on the Nasdaq or on any Subsequent Market on which the Common Stock is then
listed or quoted, as reported by Bloomberg  Information  Services,  Inc. (or any
successor entity succeeding to its function of reporting prices), or if there is
no such price on such date,  then the closing bid price on the Nasdaq or on such
Subsequent  Market on the date  nearest  preceding  such date,  as  reported  by
Bloomberg Information Services,  Inc. (or any successor entity succeeding to its
function of reporting prices),  or (b) if the Common Stock is not then listed or
quoted on the Nasdaq or a Subsequent  Market,  the closing bid price for a share
of Common  Stock in the  over-the-counter  market,  as reported by the  National
Quotation Bureau  Incorporated or similar  organization or agency  succeeding to
its functions of reporting prices) at the close of business on such date, or (c)
if the  Common  Stock is not then  reported  by the  National  Quotation  Bureau
Incorporated (or similar  organization or agency  succeeding to its functions of
reporting prices),  then the average of the "Pink Sheet" quotes for the relevant
conversion  period,  as  determined  in good faith by the Holder,  or (d) if the
Common  Stock is not then  publicly  traded the fair market  value of a share of
Common Stock as determined by an Appraiser selected in good faith by the Holders
of a  majority  of the  applicable  Warrant  Shares;  (iii)  "Person"  means  an
individual or corporation,  partnership,  trust,  incorporated or unincorporated
association,  joint venture,  limited  liability  company,  joint stock company,
government  (or an agency or  subdivision  thereof) or other entity of any kind;
and (iv)  "Trading  Day" means (a) a day on which the Common  Stock is traded on
the Nasdaq or on the Subsequent  Market on which the Common Stock is then listed
or quoted,  as the case may be, or (b) if the Common  Stock is not listed on the
Nasdaq or a Subsequent  Market, a day on which the Common Stock is traded in the
over-the-counter  market,  as reported by the OTC Bulletin Board , or (c) if the
Common Stock is not quoted on the OTC Bulletin  Board, a day on which the Common
Stock is  quoted in the  over-the-counter  market as  reported  by the  National
Quotation Bureau Incorporated (or any similar  organization or agency succeeding
its functions of reporting prices);  provided, that in the event that the Common
Stock is not  listed or quoted as set  forth in (a),  (b) and (c)  hereof,  then
Trading Day shall mean a Business Day.


                                   ARTICLE II
                         REPRESENTATIONS AND WARRANTIES

          2.1 REPRESENTATIONS AND WARRANTIES OF THE COMPANY.  The Company hereby
 makes the following representations and warranties to the Purchasers:

                   (a)  ORGANIZATION  AND   QUALIFICATION.   The  Company  is  a
corporation duly  incorporated,  validly existing and in good standing under the
laws of the State of Delaware,  with the requisite corporate power and authority
to own and use its  properties  and  assets  and to  carry  on its  business  as
currently  conducted.  The  Company  has no  subsidiaries.  The  Company is duly
qualified to do business  and is in good  standing as a foreign  corporation  or
other entity in each jurisdiction in which the nature of the business  conducted
or property  owned by it makes such  qualification  necessary,  except where the
failure to be so qualified or in good  standing,  as the case may be, could not,
individually or in the aggregate, reasonably be expected to (x) adversely affect
the legality, validity or enforceability of the Securities (as defined below) or
any of this Agreement,  the Registration  Rights  Agreement,  the Transfer Agent
Instructions or the Warrants (collectively,  the "Transaction  Documents"),  (y)
have or result  in a  material  adverse  effect on the  results  of  operations,
assets, or condition  (financial or otherwise) of the Company,  or (z) adversely
impair the Company's  ability to perform fully on a timely basis its obligations
under any of the  Transaction  Documents  (any of (x),  (y) or (z), a  "Material
Adverse Effect").

                  (b) AUTHORIZATION;  ENFORCEMENT. The Company has the requisite
corporate  power and authority to enter into and to consummate the  transactions
contemplated by each of the Transaction Documents and otherwise to carry out its
obligations  thereunder.  The execution and delivery of each of the  Transaction
Documents  by  the  Company  and  the  consummation  by it of  the  transactions
contemplated  thereby have been duly  authorized by all necessary  action on the
part of the Company and no further  action is required by the  Company.  Each of
the  Transaction  Documents  has been duly  executed  by the Company  and,  when
delivered in accordance  with the terms hereof,  will  constitute  the valid and
binding obligation of the Company  enforceable against the Company in accordance
with its terms,  except to the extent that enforcement thereof may be limited by
(i) bankruptcy,  insolvency,  reorganization,  moratorium or similar laws now or
hereafter in effect  relating to  creditors'  rights  generally and (ii) general
principles of equity  (regardless of whether  enforceability  is considered in a
proceeding  at law or in  equity)  and  except  to the  extent  that  rights  to
indemnification  and contribution  contained in this Agreement may be limited by
federal or state securities laws on public policy relating thereto.  The Company
is not in violation of any of the provisions of its certificate of incorporation
or by-laws.

                  (c)  CAPITALIZATION.  The  number of  authorized,  issued  and
outstanding  shares of capital  stock of the Company as of September 30, 2000 is
set  forth in  Schedule  2.1(c).  No shares of  Common  Stock  are  entitled  to
preemptive or similar rights, nor is any holder of the securities of the Company
entitled  to  preemptive  or similar  rights  arising  out of any  agreement  or
understanding  with the Company by virtue of any of the  Transaction  Documents.
Except as a result of the  purchase  and sale of the Shares and the Warrants and
except as disclosed in Schedule  2.1(c),  as of September  30, 2000 there are no
outstanding  options,   warrants,  script  rights  to  subscribe  to,  calls  or
commitments of any character  whatsoever  relating to, or securities,  rights or
obligations convertible into or exchangeable for, or giving any Person any right
to  subscribe  for or  acquire,  any  shares  of  Common  Stock,  or  contracts,
commitments,  understandings,  or  arrangements  by which the  Company is or may
become bound to issue additional shares of Common Stock, or securities or rights
convertible or exchangeable into shares of Common Stock.

                  (d) ISSUANCE OF THE SECURITIES.  The Shares and the Underlying
Shares are duly  authorized and, when issued and paid for in accordance with the
terms hereof and the Warrants,  shall have been duly and validly  issued,  fully
paid and nonassessable,  free and clear of all liens, encumbrances and rights of
first refusal of any kind  (collectively,  "Liens").  The Company has reserved a
number of duly authorized shares of Common Stock for issuance hereunder and upon
exercise of the  Warrants  that is not less than the sum of (i) the Shares to be
issued  hereunder;  (ii) the  number of shares of  Common  Stock  issuable  upon
exercise of the Adjustable Warrants on the First Vesting Date (as defined in the
Adjustable Warrant), assuming for such purposes that, on the First Vesting Date,
(A) the Applicable  Share Number (as defined in the Adjustable  Warrant)  equals
the entire number of Shares purchased hereunder and (B) the Adjustment Price (as
defined in the Adjustable  Warrant)  equals 60% of the Per Share Market Value on
the Trading Day immediately  preceding the Closing Date, and (iii) the number of
shares of Common Stock  issuable upon  exercise in full of the Closing  Warrants
(the number of shares of Common Stock  contemplated in (i), (ii) and (iii),  the
"Initial  Minimum").  The shares of Common Stock  issuable  upon exercise of the
Warrants are  referred to herein as the  "Underlying  Shares."  The Shares,  the
Warrants and the Underlying  Shares are collectively  referred to herein as, the
"Securities."

                   (e) NO CONFLICTS. The execution,  delivery and performance of
the Transaction  Documents by the Company and the consummation by the Company of
the transactions  contemplated  thereby do not and will not (i) conflict with or
violate any provision of the Company's  certificate of  incorporation  or bylaws
(each as amended  through the date  hereof),  or (ii) subject to  obtaining  the
Required  Approvals (as defined  below),  conflict with, or constitute a default
(or an event which with notice or lapse of time or both would  become a default)
under, or give to others any rights of termination,  amendment,  acceleration or
cancellation (with or without notice,  lapse of time or both) of, any agreement,
credit  facility,  debt  or  other  instrument  (evidencing  a  Company  debt or
otherwise)  or other  understanding  to which the Company is a party or by which
any property or asset of the Company is bound or affected,  or (iii) result in a
violation of any law, rule, regulation,  order, judgment,  injunction, decree or
other restriction of any court or governmental authority to which the Company is
subject  (including  federal and state securities laws and  regulations),  or by
which any property or asset of the Company is bound or  affected;  except in the
case of each of clauses  (ii) and (iii),  as could not,  individually  or in the
aggregate,  reasonably  be  expected  to have or  result in a  Material  Adverse
Effect.  The business of the Company is not being  conducted in violation of any
law,  ordinance  or  regulation  of  any  governmental  authority,   except  for
violations  which,  individually  or in the  aggregate,  could not reasonably be
expected to have or result in a Material Adverse Effect.

                  (f)  FILINGS,  CONSENTS  AND  APPROVALS.  The  Company  is not
required  to obtain any  consent,  waiver,  authorization  or order of, give any
notice to, or make any filing or registration  with, any court or other federal,
state, local or other governmental  authority or other Person in connection with
the  execution,  delivery  and  performance  by the  Company of the  Transaction
Documents,  other than (i) the filings  required  pursuant to Section 3.10, (ii)
the filing with the Securities and Exchange  Commission (the  "Commission") of a
registration  statement  meeting the  requirements set forth in the Registration
Rights Agreement and covering the resale of the Shares and the Underlying Shares
by the Purchasers (the "Underlying Shares  Registration  Statement"),  (iii) the
application(s)  to the Nasdaq National Market  ("NASDAQ") for the listing of the
Underlying  Shares  for  trading  on the  NASDAQ  (and with any  other  national
securities  exchange or market on which the Common  Stock is then listed) in the
time and manner required thereby;  (iv) applicable Blue Sky filings, if any, and
(v) in all  other  cases  where the  failure  to obtain  such  consent,  waiver,
authorization  or  order,  or to  give  such  notice  or  make  such  filing  or
registration could not reasonably be expected to have or result in, individually
or in the  aggregate,  a Material  Adverse Effect  (collectively,  the "Required
Approvals").

                  (g)  LITIGATION;   PROCEEDINGS.  There  is  no  action,  suit,
inquiry,  notice of violation,  proceeding or  investigation  pending or, to the
knowledge of the Company,  threatened against or affecting the Company or any of
its   properties   before  or  by  any  court,   arbitrator,   governmental   or
administrative agency or regulatory authority (federal,  state, county, local or
foreign)  (collectively,  an "Action") which (i) adversely affects or challenges
the legality,  validity or enforceability of any of the Transaction Documents or
the Securities or (ii) could,  individually  or in the aggregate,  reasonably be
expected to have or result in a Material Adverse Effect.

                   (h) NO  DEFAULT  OR  VIOLATION.  The  Company  is not  (i) in
default  under or in violation of (and no event has occurred  which has not been
waived which, with notice or lapse of time or both, would result in a default by
the Company under), nor has the Company received notice of a claim that it is in
default  under or that it is in  violation  of,  any  indenture,  loan or credit
agreement  or any other  agreement  or  instrument  to which it is a party or by
which it or any of its  properties  is bound,  (ii) in violation of any order of
any  court,  arbitrator  or  governmental  body,  or (iii) in  violation  of any
statute, rule or regulation of any governmental  authority,  except as could not
individually or in the aggregate,  reasonably be expected to have or result in a
Material Adverse Effect.

                  (i)   PRIVATE   OFFERING.   Assuming   the   accuracy  of  the
representations   and  warranties  of  the  Purchasers  set  forth  in  Sections
2.2(b)-(g),  the offer, issuance and sale of the Securities to the Purchasers as
contemplated  hereby  are  exempt  from  the  registration  requirements  of the
Securities Act of 1933, as amended (the "Securities  Act").  Neither the Company
nor any Person  acting on its behalf  has taken or is, to the  knowledge  of the
Company,  contemplating  taking any action  which could  subject  the  offering,
issuance  or sale of the  Securities  to the  registration  requirements  of the
Securities  Act including  soliciting any offer to buy or sell the Securities by
means of any form of general solicitation or advertising.

                   (j) SEC  DOCUMENTS;  FINANCIAL  STATEMENTS.  The  Company has
filed all reports  required to be filed by it under the Securities  Exchange Act
of 1934, as amended (the "Exchange Act"), including pursuant to Section 13(a) or
15(d)  thereof,  for the two years  preceding  the date hereof (or such  shorter
period as the Company was required by law to file such  material) (the foregoing
materials  being  collectively  referred to herein as the "SEC  Documents"  and,
together with the Schedules to this Agreement,  the "Disclosure Materials") on a
timely  basis or has  received a valid  extension of such time of filing and has
filed any such SEC Documents prior to the expiration of any such  extension.  As
of their respective  dates, the SEC Documents  complied in all material respects
with the  requirements  of the Securities Act and the Exchange Act and the rules
and regulations of the Commission  promulgated  thereunder,  and none of the SEC
Documents,  when filed,  contained  any untrue  statement of a material  fact or
omitted to state a material fact  required to be stated  therein or necessary in
order to make the statements  therein, in light of the circumstances under which
they were made, not misleading.  All material agreements to which the Company is
a party or to which the  property or assets of the Company are subject have been
filed as exhibits to the SEC  Documents as required  under the Exchange Act. The
financial  statements of the Company included in the SEC Documents comply in all
material  respects with  applicable  accounting  requirements  and the rules and
regulations of the Commission  with respect  thereto as in effect at the time of
filing.  Such  financial  statements  have  been  prepared  in  accordance  with
generally  accepted  accounting  principles applied on a consistent basis during
the periods  involved  ("GAAP"),  except as may be  otherwise  specified in such
financial  statements or the notes  thereto,  and fairly present in all material
respects the  financial  position of the Company as of and for the dates thereof
and the  results  of  operations  and cash  flows for the  periods  then  ended,
subject, in the case of unaudited statements,  to normal,  immaterial,  year-end
audit  adjustments.  Since  December 31,  1999,  except as set forth on Schedule
2.1(j) or  specifically  disclosed in the SEC  Documents,  (a) there has been no
event,  occurrence or development  that has or that could reasonably be expected
to result in a Material  Adverse  Effect,  (b) the Company has not  incurred any
liabilities (contingent or otherwise) other than (x) liabilities incurred in the
ordinary course of business consistent with past practice and (y) liabilities of
a type not  required  to be  reflected  in the  Company's  financial  statements
pursuant  to  GAAP  or  required  to be  disclosed  in  filings  made  with  the
Commission,  (c) the Company has not  altered  its method of  accounting  or the
identity  of its  auditors  and (d) the  Company  has not  declared  or made any
payment  or  distribution  of cash or  other  property  to its  stockholders  or
officers or directors  (other than in  compliance  with  existing  Company stock
option  plans) with respect to its capital  stock,  or purchased or redeemed (or
made any agreements to purchase or redeem) any shares of its capital stock.

                  (k)  INVESTMENT  COMPANY.  The  Company is not,  and is not an
 Affiliate (as defined in Rule 405 under the Securities  Act) of, an "investment
 company"  as such term is defined in the  Investment  Company  Act of 1940,  as
 amended.
                  (l) CERTAIN  FEES.  Except for certain fees payable to Leerink
Swann and Company,  as set forth on Schedule 2.1(l), no fees or commissions will
be  payable by the  Company  to any  broker,  financial  advisor or  consultant,
finder, placement agent, investment banker, bank or other Person with respect to
the  transactions  contemplated by this Agreement.  The Purchasers shall have no
obligation  with respect to any fees or with respect to any claims made by or on
behalf of other Persons for fees of a type contemplated in this Section that may
be due in connection with the transactions  contemplated by this Agreement.  The
Company  shall  indemnify  and hold harmless the  Purchasers,  their  employees,
officers, directors, agents, and partners, and their respective Affiliates, from
and  against  all  claims,  losses,  damages,  costs  (including  the  costs  of
preparation  and attorney's  fees) and expenses  suffered in respect of any such
claimed or existing fees, as such fees and expenses are incurred.

                  (m) SOLICITATION MATERIALS. Neither the Company nor any Person
 acting  on the  Company's  behalf  has  solicited  any offer to buy or sell the
 Securities by means of any form of general solicitation or advertising.

                  (n) FORM S-3 ELIGIBILITY.  The Company is eligible to register
its Common Stock for resale under Form S-3 promulgated under the Securities Act.

                  (o) LISTING AND MAINTENANCE REQUIREMENTS.  Except as set forth
in the SEC Documents,  the Company has not, in the two years  preceding the date
hereof,  received  notice  (written or oral) from the NASDAQ any stock exchange,
market or trading  facility on which the Common  Stock is or has been listed (or
on which it has been quoted) to the effect that the Company is not in compliance
with the listing or maintenance requirements of such exchange, market or trading
facility.  The Company is, and has no reason to believe  that it will not in the
foreseeable  future  continue  to be, in  compliance  with all such  listing and
maintenance requirements.

                  (p) PATENTS AND TRADEMARKS.  The Company has, or has rights to
use, all  patents,  patent  applications,  trademarks,  trademark  applications,
service marks, trade names, copyrights,  licenses and rights which are necessary
or material  for use in  connection  with its  business as  described in the SEC
Documents, except where the failure to so have would not have a Material Adverse
Effect (collectively,  the "Intellectual  Property Rights").  Since December 31,
1999,  the  Company  has not  received a written  notice  that any  Intellectual
Property Rights used by the Company violates or infringes upon the rights of any
Person. To the knowledge of the Company,  all such Intellectual  Property Rights
are enforceable  and there is no existing  infringement by another Person of any
of the Intellectual Property Rights.

                   (q) REGISTRATION RIGHTS;  RIGHTS OF PARTICIPATION.  Except as
set forth on Schedule 6(b) to the Registration Rights Agreement, the Company has
not granted or agreed to grant to any Person any rights (including  "piggy-back"
registration  rights) to have any securities of the Company  registered with the
Commission or any other  governmental  authority  which have not been satisfied.
Except as set forth on Schedule 6(b) to the Registration  Rights  Agreement,  no
Person has any right of first refusal, preemptive right, right of participation,
or any similar right to  participate  in the  transactions  contemplated  by the
Transaction Documents.

                  (r) REGULATORY PERMITS.  The Company possess all certificates,
authorizations and permits issued by the appropriate  federal,  state or foreign
regulatory authorities necessary to conduct its business as described in the SEC
Documents,  except  where  the  failure  to  possess  such  permits  could  not,
individually or in the aggregate,  reasonably be expected to have or result in a
Material Adverse Effect ("Material  Permits"),  and the Company has not received
any notice of  proceedings  relating to the  revocation or  modification  of any
Material Permit.

                  (s) TITLE. Except as set forth on Schedule 2.1(s), the Company
has good and  marketable  title in fee simple to all real  property  owned by it
which is material to the business of the Company and good and  marketable  title
in all  personal  property  owned by it which is material to the business of the
Company,  free and clear of all  Liens,  except  for Liens as do not  materially
affect the value of such  property  and do not  interfere  with the use made and
proposed  to be made of such  property by the  Company.  Any real  property  and
facilities  held  under  lease  by the  Company  are  held  by it  under  valid,
subsisting and enforceable leases with which the Company is in compliance and do
not prohibit the use made and proposed to be made of such property and buildings
by the Company.

                  (t) ABSENCE OF CERTAIN PROCEEDINGS. Except as described in the
SEC  Documents,  (i) there is no Action  pending  or,  to the  knowledge  of the
Company, threatened against the Company, in any such case wherein an unfavorable
decision,  ruling or finding could reasonably be expected to have or result in a
Material Adverse Effect; (ii) neither the Company,  nor, to the knowledge of the
Company,  any  director  or officer  thereof,  is or has been the subject of any
Action involving (A) a claim of violation of or liability under federal or state
securities  laws or (B) a claim of breach of fiduciary  duty;  (iii) the Company
does not have  pending  before  the  Commission  any  request  for  confidential
treatment of information  and the Company has no knowledge that any such request
will be made prior to the  Effectiveness  Date (as  defined in the  Registration
Rights  Agreement);  and (iv) there has not been,  and to the  knowledge  of the
Company  there  is  not  pending  or  contemplated,  any  investigation  by  the
Commission  involving  the  Company or, to the  knowledge  of the  Company,  any
current or former director or officer of the Company.

                  (u) LABOR  RELATIONS.  No material labor problem exists or, to
 the knowledge of the Company,  is imminent with respect to any of the employees
 of the Company.

                   (v) DISCLOSURE.  The Company confirms that neither it nor any
other  Person  acting on its behalf has provided  any of the  Purchasers  or its
agents or counsel with any  information  that  constitutes  or might  constitute
material non-public  information.  The Company understands and confirms that the
Purchasers  shall be  relying  on the  foregoing  representations  in  effecting
transactions  in  securities  of the  Company.  All  disclosure  provided to the
Purchasers regarding the Company, its business and the transactions contemplated
hereby, including the Schedules to this Agreement,  furnished by or on behalf of
the Company do not contain any untrue  statement  of a material  fact or omit to
state any material fact necessary in order to make the statements  made therein,
in light of the circumstances under which they were made, not misleading.

                  2.2  REPRESENTATIONS  AND WARRANTIES OF THE  PURCHASERS.  Each
 Purchaser hereby for itself and for no other Purchaser  represents and warrants
 to the Company as follows:

                  (a) ORGANIZATION;  AUTHORITY. Such Purchaser is an entity duly
organized,  validly  existing  and  in  good  standing  under  the  laws  of the
jurisdiction  of its  organization  with the requisite  corporate or partnership
power  and  authority  to  enter  into  and  to  consummate   the   transactions
contemplated  by the  Transaction  Documents  and  otherwise  to  carry  out its
obligations  thereunder.  The  purchase  by  such  Purchaser  of the  Securities
hereunder has been duly  authorized by all necessary  action on the part of such
Purchaser. Each of this Agreement and the Registration Rights Agreement has been
duly  executed  by such  Purchaser,  and when  delivered  by such  Purchaser  in
accordance with the terms hereof,  will constitute the valid and legally binding
obligation of such  Purchaser,  enforceable  against it in  accordance  with its
terms,  except to the  extent  that  enforcement  thereof  may be limited by (i)
bankruptcy,  insolvency,  reorganization,  moratorium  or  similar  laws  now or
hereafter in effect  relating to  creditors'  rights  generally and (ii) general
principles of equity  (regardless of whether  enforceability  is considered in a
proceeding  at law or in  equity)  and  except  to the  extent  that  rights  to
indemnification  and contribution  contained in this Agreement may be limited by
federal or state securities laws on public policy relating thereto.

                  (b)  INVESTMENT  INTENT.   Such  Purchaser  is  acquiring  the
Securities as principal for its own account for investment purposes only and not
with a view to or for  distributing  or reselling  such  Securities  or any part
thereof,  without prejudice,  however, to such Purchaser's right, subject to the
provisions  of  this  Agreement,  the  Registration  Rights  Agreement  and  the
Warrants,  at all times to sell or otherwise  dispose of all or any part of such
Securities pursuant to an effective  registration statement under the Securities
Act or  under  an  exemption  from  such  registration  and in  compliance  with
applicable  federal and state securities laws. Nothing contained herein shall be
deemed a representation or warranty by such Purchaser to hold Securities for any
period of time.  Such  Purchaser is acquiring  the  Securities  hereunder in the
ordinary  course of its business.  Such Purchaser does not have any agreement or
understanding,  directly  or  indirectly,  with any  Person  to  distribute  the
Securities.

                  (c) PURCHASER  STATUS.  At the time such Purchaser was offered
the Securities,  it was, and at the date hereof it is, and at each exercise date
under its respective Warrants,  it will be, an "accredited  investor" as defined
in Rule 501(a) under the Securities Act.

                  (d) EXPERIENCE OF SUCH PURCHASER. Such Purchaser, either alone
or together with its  representatives,  has such knowledge,  sophistication  and
experience in business and  financial  matters so as to be capable of evaluating
the merits and risks of the prospective investment in the Securities, and has so
evaluated the merits and risks of such investment.

                  (e) ABILITY OF SUCH PURCHASER TO BEAR RISK OF INVESTMENT. Such
Purchaser is able to bear the economic risk of an  investment in the  Securities
and, at the present time, is able to afford a complete loss of such investment.

                   (f) ACCESS TO INFORMATION.  Such Purchaser  acknowledges that
it has  reviewed  the  Disclosure  Materials  and  has  been  afforded  (i)  the
opportunity to ask such questions as it has deemed  necessary of, and to receive
answers from, representatives of the Company concerning the terms and conditions
of the offering of the  Securities  and the merits and risks of investing in the
Securities;  (ii) access to  information  about the  Company  and the  Company's
financial condition, results of operations, business, properties, management and
prospects  sufficient  to enable it to evaluate  its  investment;  and (iii) the
opportunity to obtain such additional information which the Company possesses or
can acquire without  unreasonable effort or expense that is necessary to make an
informed  investment  decision with respect to the  investment and to verify the
accuracy  and  completeness  of the  information  contained  in  the  Disclosure
Materials. Neither such inquiries nor any other investigation conducted by or on
behalf of such Purchaser or its  representatives or counsel shall modify,  amend
or affect such Purchaser's right to rely on the truth, accuracy and completeness
of the  Disclosure  Materials and the Company's  representations  and warranties
contained in the Transaction Documents.

                  (g) GENERAL SOLICITATION. Such Purchaser is not purchasing the
Securities as a result of or subsequent to any advertisement, article, notice or
other  communication  regarding  the  Securities  published  in  any  newspaper,
magazine or similar media or broadcast over  television or radio or presented at
any seminar or any other general solicitation or general advertisement.

                  (h) RELIANCE. Such Purchaser understands and acknowledges that
(i) the Securities are being offered and sold to it without  registration  under
the Securities Act in a private  placement that is exempt from the  registration
provisions of the Securities Act and (ii) the  availability  of such  exemption,
depends in part on, and the Company will rely upon the accuracy and truthfulness
of, the foregoing  representations  and  warranties  and such  Purchaser  hereby
consents to such reliance.

                  The Company acknowledges and agrees that no Purchaser makes or
has made any  representations  or  warranties  with respect to the  transactions
contemplated hereby other than those specifically set forth in this Section 2.2.


                                   ARTICLE III
                         OTHER AGREEMENTS OF THE PARTIES

         3.1  TRANSFER  RESTRICTIONS.  (a)  Securities  may only be  disposed of
pursuant to an effective registration statement under the Securities Act, to the
Company or pursuant  to an  available  exemption  from or in a  transaction  not
subject  to  the  registration  requirements  of  the  Securities  Act,  and  in
compliance with any applicable  federal and state securities laws. In connection
with any transfer of Securities other than pursuant to an effective registration
statement or to the Company,  except as otherwise set forth herein,  the Company
may  require  the  transferor  thereof to  provide to the  Company an opinion of
counsel reasonably  satisfactory to the Company selected by the transferor,  the
form and  substance of which opinion  shall be  reasonably  satisfactory  to the
Company, to the effect that such transfer does not require  registration of such
transferred Securities under the Securities Act.  Notwithstanding the foregoing,
the Company,  without  requiring a legal opinion as described in the immediately
preceding  sentence,  hereby  consents to and agrees to register on the books of
the Company and with any transfer  agent for the  securities  of the Company any
transfer of  Securities  by a Purchaser to an Affiliate of such  Purchaser or to
one or more  funds  or  managed  accounts  under  common  management  with  such
Purchaser,  and any transfer  among any such  Affiliates or one or more funds or
managed accounts,  provided that the transferee certifies to the Company that it
is an  "accredited  investor" as defined in Rule 501(a) under the Securities Act
and that it is acquiring the Securities solely for investment  purposes (subject
to the qualifications  hereof). Any such transferee shall agree in writing to be
bound by the terms of this  Agreement  and shall have the rights of a  Purchaser
under this Agreement and the Registration Rights Agreement.

                  (b) The  Purchasers  agree  to the  imprinting,  so long as is
 required by this Section 3.1(b), of the following legend on the Securities:

                  NEITHER THESE  SECURITIES NOR THE SECURITIES  INTO WHICH THESE
         SECURITIES ARE EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND
         EXCHANGE  COMMISSION  OR THE  SECURITIES  COMMISSION  OF ANY  STATE  IN
         RELIANCE UPON AN EXEMPTION FROM  REGISTRATION  UNDER THE SECURITIES ACT
         OF 1933, AS AMENDED (THE "SECURITIES ACT"), AND,  ACCORDINGLY,  MAY NOT
         BE  OFFERED  OR  SOLD  EXCEPT  PURSUANT  TO AN  EFFECTIVE  REGISTRATION
         STATEMENT  UNDER  THE  SECURITIES  ACT  OR  PURSUANT  TO  AN  AVAILABLE
         EXEMPTION  FROM, OR IN A TRANSACTION  NOT SUBJECT TO, THE  REGISTRATION
         REQUIREMENTS  OF THE SECURITIES ACT AND IN ACCORDANCE  WITH  APPLICABLE
         STATE SECURITIES LAWS.

                  Neither the Shares nor the Underlying Shares shall contain the
legend  set  forth  above  nor any  other  legend  while  an  Underlying  Shares
Registration  Statement is effective  under the  Securities Act or the holder is
relying  on Rule 144  promulgated  under  the  Securities  Act  ("Rule  144") in
connection with the resale of such Underlying  Shares,  or in the event there is
not an effective  Underlying Shares  Registration  Statement and Rule 144 is not
then available for resale of the Underlying Shares, at such time, as such legend
is not required under  applicable  requirements of the Securities Act (including
judicial   interpretations  and  pronouncements  issued  by  the  staff  of  the
Commission).  The Company  shall  cause its  counsel to issue the legal  opinion
included in the Transfer Agent  Instructions to the Company's  transfer agent on
the  date  that  such  Underlying  Shares  Registration  Statement  is  declared
effective by the Commission  (the  "Effective  Date").  The Company agrees that,
following  the  Effective  Date,  it will,  no later than three (3) Trading Days
following  the  delivery  by a  Purchaser  to the  Company of a  certificate  or
certificates  representing  Shares,  deliver  to  such  Purchaser  an  identical
certificate or  certificates  representing  such Shares which shall be free from
such legend.  The Company further agrees that if any Shares or Underlying Shares
are issued with a legend in accordance with this Section 3.1(b), it will, within
three (3) Trading  Days after  request  therefor by a  Purchaser,  provide  such
Purchaser  with a  certificate  or  certificates  representing  such  Shares  or
Underlying  Shares,  free from such legend at such time as such legend would not
have been required under this Section  3.1(b) had such issuance  occurred on the
date of such  request.  The Company may not make any  notation on its records or
give  instructions  to any  transfer  agent of the  Company  which  enlarge  the
restrictions of transfer set forth in this Section.

         3.2  ACKNOWLEDGMENT  OF  DILUTION.  The Company  acknowledges  that the
issuance of  Underlying  Shares upon  exercise  of the  Warrants  will result in
dilution  of the  outstanding  shares of Common  Stock,  which  dilution  may be
substantial under certain market  conditions.  The Company further  acknowledges
that its obligation to issue Underlying Shares upon exercise of the Warrants, is
unconditional  and  absolute,  subject  to  the  limitations  set  forth  in the
Warrants, regardless of the effect of any such dilution.

         3.3  FURNISHING  OF   INFORMATION.   As  long  as  the  Purchasers  own
Securities,  the  Company  covenants  to timely  file (or obtain  extensions  in
respect  thereof  and file  within the  applicable  grace  period)  all  reports
required  to be filed by the Company  after the date hereof  pursuant to Section
13(a) or 15(d) of the Exchange Act. As long as the Purchasers own Securities, if
the Company is not required to file reports  pursuant to such sections,  it will
prepare and furnish to the Purchasers and make publicly  available in accordance
with Rule 144(c)  promulgated  under the Securities  Act such  information as is
required for the  Purchasers to sell the Securities  under Rule 144  promulgated
under the Securities Act. The Company  further  covenants that it will take such
further action as any holder of Securities may  reasonably  request,  all to the
extent  required  from time to time to  enable  such  Person to sell  Underlying
Shares  without  registration  under the Securities Act within the limitation of
the  exemptions  provided  by Rule 144  promulgated  under the  Securities  Act,
including causing its attorneys to render and deliver any legal opinion required
in  order  to  permit a  Purchaser  to  receive  Underlying  Shares  free of all
restrictive  legends and to subsequently  sell Underlying  Shares under Rule 144
upon receipt of a notice of an intention to sell or other form of notice  having
a similar effect. Upon the request of any such Person, the Company shall deliver
to such  Person a  written  certification  of a duly  authorized  officer  as to
whether it has complied with such requirements.

         3.4 INTEGRATION.  The Company shall not, and shall use its best efforts
to ensure  that,  no  Affiliate of the Company  shall,  sell,  offer for sale or
solicit  offers to buy or  otherwise  negotiate  in respect of any  security (as
defined in Section 2 of the  Securities  Act) that would be integrated  with the
offer or sale of the Securities in a manner that would require the  registration
under the  Securities Act of the sale of the  Securities to the  Purchasers,  or
that  would be  integrated  with the  offer  or sale of the  Securities  for the
purposes of the rules and regulations of NASDAQ.

         3.5 INCREASE IN AUTHORIZED SHARES. If on any date the Company would be,
if a notice of  exercise  were to be  delivered  on such  date,  precluded  from
issuing the sum of (i) 200% of the number of  Underlying  Shares  then  issuable
upon  exercise  in full of the  Adjustable  Warrants  and  (ii)  the  number  of
Underlying  Shares  issuable upon exercise in full of the Closing  Warrants (the
"Current Required  Minimum") due to the unavailability of a sufficient number of
authorized  but unissued or reserved  shares of Common Stock,  then the Board of
Directors of the Company  shall  promptly  (and in any case,  within 30 Business
Days from such date) prepare and mail to the  stockholders  of the Company proxy
materials  requesting  authorization  to  amend  the  Company's  certificate  of
incorporation to increase the number of shares of Common Stock which the Company
is authorized to issue to at least such number of shares as reasonably requested
by the Purchasers in order to provide for such number of authorized and unissued
shares of Common  Stock to  enable  the  Company  to comply  with its  issuance,
exercise and  reservation  of shares  obligations as set forth in this Agreement
and the  Warrants  (the sum of (x) the  number of shares  of Common  Stock  then
outstanding  plus all  shares of Common  Stock  issuable  upon  exercise  of all
outstanding  options,  warrants  and  convertible  instruments  other  than  the
Warrants and (y) the Current Required Minimum, shall be a reasonable number). In
connection therewith,  the Board of Directors shall (a) adopt proper resolutions
authorizing  such increase,  (b) recommend to and otherwise use its best efforts
to promptly and duly obtain  stockholder  approval to carry out such resolutions
(and hold a special  meeting of the  stockholders  no later than the  earlier to
occur of the 60th day after  delivery  of the proxy  materials  relating to such
meeting  and the 90th day after  request  by a holder of  Warrants  to issue the
number of Underlying  Shares in accordance with the terms hereof) and (c) within
five  Business  Days  of  obtaining  such  stockholder  authorization,  file  an
appropriate  amendment to the Company's certificate of incorporation to evidence
such  increase.  Management  of the  Company  shall  also use its best  efforts,
including  voting of all shares of Common Stock held by  management  in favor of
all resolutions to increase the authorized stock of the Company hereunder.

         3.6 RESERVATION AND LISTING OF UNDERLYING SHARES. (a) The Company shall
(i) as soon as possible  after  Closing,  prepare and file with NASDAQ (and such
other national  securities  exchange,  market,  trading or quotation facility on
which the Common Stock is then traded) an additional shares listing  application
covering a number of shares of Common  Stock  which is not less than the Initial
Minimum,  (ii) take all steps  necessary to cause such shares of Common Stock to
be  approved  for  listing in the NASDAQ (as well as on any such other  national
securities  exchange  or market or trading or  quotation  facility  on which the
Common Stock is then listed) as soon as possible  thereafter,  and (iii) provide
to the Purchasers  evidence of such listing,  and the Company shall maintain the
listing of its Common Stock thereon. If the number of Underlying Shares issuable
upon exercise of the then unexercised portion of the Warrants exceeds 85% of the
number of Underlying  Shares  previously  listed on account  thereof with NASDAQ
(and  any  such  other  required  exchanges)  then the  Company  shall  take the
necessary actions to immediately list a number of Underlying Shares equals to no
less than the then Current Required Minimum.

                  (b) The Company  shall  maintain a reserve of shares of Common
Stock for issuance upon exercise in full of the Warrants in accordance with this
Agreement and the Warrants,  respectively,  in such amount as may be required to
fulfill its obligations in full under the Transaction  Documents,  which reserve
shall equal no less than the then Current Required Minimum.

         3.7 EXERCISE  PROCEDURES.  The Transfer Agent  Instructions and Form of
Election to Purchase under the Warrants set forth the totality of the procedures
with  respect  to the  exercise  of the  Warrants,  including  the form of legal
opinion,  if necessary,  that shall be rendered to the Company's  transfer agent
and such other  information and  instructions as may be reasonably  necessary to
enable the Purchasers to exercise their Warrants.

         3.8  EXERCISE  OBLIGATIONS.  The Company  shall honor  exercises of the
 Warrants and shall  deliver  Underlying  Shares in  accordance  with the terms,
 conditions and time periods set forth in the Warrants.

         3.9 RIGHT OF FIRST REFUSAL;  SUBSEQUENT REGISTRATIONS.  (a) The Company
shall not,  directly or  indirectly,  without the prior  written  consent of the
Purchasers,  offer, sell, grant any option to purchase,  or otherwise dispose of
(or  announce  any  offer,  sale,  grant  or any  option  to  purchase  or other
disposition)   any  of  its   (or  its   subsidiaries,   if   any)   equity   or
equity-equivalent  securities  including  the  issuance  of any  debt  or  other
instrument at any time over the life thereof  convertible  into or  exchangeable
for Common  Stock,  in any  transaction  intended to be exempt or not subject to
registration under the Securities Act (collectively,  a "Subsequent  Placement")
for a period of 240 days after the Effective Date,  provided,  that such 240 day
period  shall be extended  for the number of Trading Days during such period (A)
in which trading in the Common Stock is suspended by any securities  exchange or
market or  quotation  system on which the Common  Stock is then  listed,  or (B)
during which the Underlying Shares Registration  Statement is not effective,  or
(C) during which the prospectus  included in the Underlying Shares  Registration
Statement  may not be used by the holders  thereof for the resale of  Underlying
Shares,  unless (A) the  Company  delivers to each of the  Purchasers  a written
notice  (the  "Subsequent  Placement  Notice") of its  intention  to effect such
Subsequent  Placement,  which  Subsequent  Placement  Notice  shall  describe in
reasonable detail the proposed terms of such Subsequent Placement, the amount of
proceeds intended to be raised thereunder,  the Person with whom such Subsequent
Placement  shall be  effected,  and  attached  to which shall be a term sheet or
similar document relating thereto and (B) such Purchaser shall not have notified
the Company by 6:30 p.m.  (New York City time) on the seventh  Trading Day after
its receipt of the Subsequent Placement Notice of its willingness to provide (or
to cause its sole  designee  to  provide),  subject to  completion  of  mutually
acceptable  documentation,  financing to the Company on the same terms set forth
in the Subsequent  Placement  Notice. If the Purchasers shall fail to notify the
Company of their  intention  to enter into such  negotiations  within  such time
period, the Company may effect the Subsequent  Placement  substantially upon the
terms  and to the  Persons  (or  Affiliates  of such  Persons)  set forth in the
Subsequent  Placement  Notice;  provided,  that the  Company  shall  provide the
Purchasers with a second Subsequent  Placement Notice,  and the Purchasers shall
again have the right of first refusal set forth above in this  paragraph (a), if
the Subsequent  Placement  subject to the initial  Subsequent  Placement  Notice
shall not have been  consummated  for any  reason on the terms set forth in such
Subsequent Placement Notice within forty-five Trading Days after the date of the
initial  Subsequent  Placement  Notice with the Person (or an  Affiliate of such
Person)  identified in the Subsequent  Placement Notice. If the Purchasers shall
indicate a willingness to provide financing in excess of the amount set forth in
the  Subsequent  Placement  Notice,  then each  Purchaser  shall be  entitled to
provide financing  pursuant to such Subsequent  Placement Notice up to an amount
equal to such  Purchaser's  pro-rata  portion of the aggregate  number of Shares
purchased by such Purchaser under this  Agreement,  but the Company shall not be
required to accept  financing  from the  Purchasers  in an  aggregate  amount in
excess of the amount set forth in the Subsequent  Placement Notice. The right of
first  refusal set forth in this Section  shall not apply to (i) the issuance of
any Common Stock, or options or warrants to purchase Common Stock, to employees,
officers or directors of, or consultants  to, the Company  pursuant to any stock
option or stock purchase plan or agreements  approved by the Company's  Board of
Directors,  (ii) shares of Common Stock  issuable upon exercise of any currently
outstanding   warrants  and  upon   conversion  of  any  currently   outstanding
convertible  securities  of the  Company,  in each case  disclosed  in  Schedule
2.1(c),  but not with respect to any amendment or  modification  thereto,  (iii)
shares of Common Stock issuable upon exercise of the Warrants in accordance with
their  respective  terms,  (iv) the  issuance  of the  warrants  referred  to on
Schedule  2.1(l),  and (v) the issuance of Shares of Common Stock in  connection
with a  strategic  partnership  or  other  business  transaction,  other  than a
transaction in which the principal purpose is to raise capital.

                  (b) Except for (x) Underlying  Shares,  (y) other "Registrable
Securities" (as such term is defined in the Registration Rights Agreement) to be
registered,  and securities of the Company permitted pursuant to Section 6(c) of
the  Registration  Rights Agreement to be registered,  in the Underlying  Shares
Registration Statement in accordance with the Registration Rights Agreement, and
(z) Common Stock permitted to be issued  pursuant to paragraph  (a)(i) - (iv) of
Section 3.9 (a), the Company shall not, for a period of not less than 90 Trading
Days  after the  Effective  Date,  without  the  prior  written  consent  of the
Purchasers (i) issue or sell any of its equity or  equity-equivalent  securities
pursuant to Regulation S promulgated  under the Securities Act, or (ii) register
any  securities  of the  Company.  Any days  after  the  Effective  Date  that a
Purchaser  is unable to sell  Underlying  Shares  under  the  Underlying  Shares
Registration Statement shall be added to such 90 Trading Day period.

         3.10 CERTAIN SECURITIES LAWS DISCLOSURES; PUBLICITY. The Company shall:
(i) on the  Closing  Date issue a press  release  reasonably  acceptable  to the
Purchasers  disclosing the transactions  contemplated hereby, (ii) file with the
Commission a Report on Form 8-K disclosing the transactions  contemplated hereby
within ten Business Days after the Closing Date,  and (iii) timely file with the
Commission  a Form D  promulgated  under the  Securities  Act as required  under
Regulation D promulgated  under the Securities Act and provide a copy thereof to
the Purchasers  promptly after the filing  thereof.  The Company shall,  no less
than two Business Days prior to the filing of any disclosure required by clauses
(ii) and (iii)  above,  provide a copy thereof to the  Purchasers.  Such filings
will not be made without the consent of the Purchasers,  which consent shall not
be  unreasonably  withheld or delayed.  The  Company  and the  Purchasers  shall
consult with each other in issuing any other press releases or otherwise  making
public statements or filings and other communications with the Commission or any
regulatory  agency or stock  market or  trading  facility  with  respect  to the
transactions  contemplated  hereby and neither  party shall issue any such press
release  or  otherwise  make  any  such  public  statement,   filings  or  other
communications  without the prior  written  consent of the other,  which consent
shall not be  unreasonably  withheld  or delayed,  except that no prior  consent
shall be required if such  disclosure is required by law, in which such case the
disclosing  party shall provide the other party with prior notice of such public
statement, filing or other communication.

         3.11 USE OF PROCEEDS. Except as set forth on Schedule 3.11, the Company
shall use the net proceeds from the sale of the Securities hereunder for working
capital  purposes and not for the  satisfaction  of any portion of the Company's
debt  (other  than  payment  of trade  payables  in the  ordinary  course of the
Company's  business  and prior  practices),  to  redeem  any  Company  equity or
equity-equivalent securities or to settle any outstanding litigation.

         3.12  REIMBURSEMENT.  If any  Purchaser,  other  than by  reason of its
negligence  or willful  misconduct,  becomes  involved  in any  capacity  in any
action,  proceeding or investigation brought by or against any Person, including
stockholders  of  the  Company,  in  connection  with  or  as a  result  of  the
consummation of the transactions  contemplated by the Transaction Documents, the
Company  will  reimburse  such  Purchaser  for its  reasonable  legal  and other
expenses  (including  the cost of any  investigation  preparation  and travel in
connection  therewith)  incurred in connection  therewith,  as such expenses are
incurred.  The  reimbursement  obligations  of the Company under this  paragraph
shall be in addition to any  liability  which the  Company may  otherwise  have,
shall  extend  upon the same  terms  and  conditions  to any  Affiliates  of the
Purchasers who are actually named in such action,  proceeding or  investigation,
and partners,  directors, agents, employees and controlling persons (if any), as
the case may be, of the Purchasers and any such Affiliate,  and shall be binding
upon and inure to the benefit of any  successors,  assigns,  heirs and  personal
representatives  of the Company,  the  Purchasers and any such Affiliate and any
such Person.  The Company also agrees that neither the  Purchasers  nor any such
Affiliates,  partners, directors, agents, employees or controlling persons shall
have any liability to the Company or any Person asserting claims on behalf of or
in right of the Company in connection with or as a result of the consummation of
the Transaction Documents except to the extent that any losses, claims, damages,
liabilities  or expenses  incurred by the Company  result from the negligence or
willful misconduct of the applicable  Purchaser or entity in connection with the
transactions contemplated by this Agreement.

         3.13     PUT OPTION.

                  (a) For a period of ten Business Days  commencing on the 210th
day following the Effective Date, the Company shall have the right,  upon notice
to the  Purchasers  (a "Put  Notice"),  to sell to each  Purchaser  a number  of
additional shares of Common Stock determined by dividing $3.5 million by 105% of
the average  closing  bid price of the Common  Stock for the five  trading  days
prior to the  Second  Closing  (which  number  shall  be  subject  to  equitable
adjustment for stock splits, recombinations and similar events (in each instance
the "Second Closing Shares"). The closing of the purchase and sale of the Second
Closing Shares  contemplated by this provision (the "Second Closing") shall take
place at the offices of MZRL,  450 Park Avenue,  New York, New York 10022 on the
thirtieth Business Day following receipt of the Put Notice, or such earlier date
agreed to in writing by the Purchasers and the Company.

                  (b) At the Second Closing,  the parties shall deliver or shall
cause to be  delivered  the  following:  (A) the Company  shall  deliver to each
Purchaser (1) a stock certificate representing Second Closing Shares, registered
in  the  name  of  such  Purchaser,  (2)  a  Securities  Purchase  Agreement  in
substantially   the  form  of  this  Agreement  (the  "Second  Closing  Purchase
Agreement"),  (3) a Common Stock purchase warrant,  in substantially the form of
Exhibit A,  registered  in the name of such  Purchaser,  pursuant  to which such
Purchaser  shall have the right to acquire shares of Common Stock upon the terms
and in such  number as set forth  therein  (each a  "Second  Closing  Adjustable
Warrant"),  (4) a Common Stock purchase  warrant,  in substantially  the form of
Exhibit B,  registered  in the name of such  Purchaser,  pursuant  to which such
Purchaser  shall have the right to acquire  20% of the number of Second  Closing
Shares at the exercise price set forth therein (each, a "Second Closing Warrant"
and together with the Second Closing Adjustable Warrants,  the "Warrants"),  (5)
the legal opinion of Ropes & Gray, outside counsel to the Company, substantially
in the form of Exhibit C, (6) an executed  Registration Rights Agreement,  dated
the date hereof, among the Company and the Purchasers, substantially in the form
of Exhibit D (the "Second Closing  Registration  Rights  Agreement") and (7) the
Transfer Agent Instructions, substantially in the form of Exhibit E, executed by
the Company and delivered to and  acknowledged  by the Company's  transfer agent
(the "Transfer Agent  Instructions");  and (B) each Purchaser shall deliver: (1)
the purchase price indicated below such  Purchaser's  name on the signature page
to this Agreement in immediately  available funds by wire transfer to an account
designated  in writing by the Company for such purpose,  (2) an executed  Second
Closing  Registration  Rights  Agreement,  and (3) an  executed  Second  Closing
Purchase Agreement.

                  (c) The obligation of each Purchaser to acquire Second Closing
Shares on the Second Closing Date is subject to the  satisfaction by the Company
or waiver by such  Purchaser,  at or before the Second  Closing Date, of each of
the following conditions:

                           (i)  ACCURACY OF THE  COMPANY'S  REPRESENTATIONS  AND
 WARRANTIES.  The representations and warranties of the Company contained in the
 Second  Closing  Purchase  Agreement  shall be true and correct in all material
 respects as of the Second Closing Date (any representations  given herein as of
 a recent practicable date shall be given as of a reasonable practicable date in
 the Second Purchase Agreement);

                           (ii) NO  INJUNCTION.  No statute,  rule,  regulation,
 executive order, decree, ruling or injunction shall have been enacted, entered,
 promulgated  or endorsed by any court or  governmental  authority  of competent
 jurisdiction  which  prohibits  the  consummation  of any  of the  transactions
 contemplated by the Transaction Documents;

                           (iii) NO  SUSPENSIONS  OF  TRADING  IN COMMON  STOCK;
 LISTING.  The trading in the Common Stock shall not have been  suspended by the
 Commission or on the Nasdaq Stock Market (except for any suspensions of trading
 of not more than one  Trading  Day solely to permit  dissemination  of material
 information  regarding the Company) at any time since the Closing Date, and the
 Common  Stock shall have been at all times  since the  Closing  Date listed for
 trading on The Nasdaq Stock Market;

                           (iv) CLOSING  THRESHOLD.  For the thirty Trading Days
 immediately preceding each of (a) the date that the Put Notice is delivered and
 (b) the Second  Closing Date,  the average  daily trading  volume of the Common
 Stock on the NASDAQ Stock Market as reported by Bloomberg LP, shall be at least
 100,000  shares and the  average of the Per Share  Market  Value for the thirty
 Trading  Day  period  immediately  preceding  each of (a) the date that the Put
 Notice is  delivered  and (b) the Second  Closing  Date shall be at least $6.35
 (subject to adjustment in the event of stock splits and similar events); and

                           (v) Adverse  Changes.  Since the date of execution of
 this Agreement, no event or series of events which reasonable could be expected
 to have or result in a Material Adverse Effect shall have occurred.

         3.14  ADDITIONAL  SHARE  ISSUANCES.  In the event that on or before the
 240th day  following  the  Effective  Date,  the Company  effects a  Subsequent
 Placement at a per share price less than the lesser of (a) the Per Share Market
 Value on the date of such  Subsequent  Placement  or (b) the Per  Share  Price,
 then, and upon the closing of such Subsequent Placement the Company shall issue
 to each Purchaser a number of additional  shares of Common Stock  determined in
 accordance with the following formula:

Additional Shares to be issued =    (N+X      -1)    Multiplied by (Z)
                                    ----
                                    (N+M


Where:

N   =  total shares outstanding prior to dilutive issuance

M   =  additional shares that the consideration received by the Company in the
       dilutive issuance would have purchased using the original deal price

X   =  number of shares issued in the dilutive issuance

Z   =  the number of shares of Common Stock purchased by such Purchaser

         The Per Share Price and the number of shares of Common Stock  purchased
by  such  Purchaser  shall  be   proportionately   adjusted  by  reason  of  any
recapitalization,  combination,  stock  split,  stock  dividend or the like with
respect to the Common Stock.

                                   ARTICLE IV
                                  MISCELLANEOUS

         4.1 FEES AND EXPENSES.  At the Closing the Company shall  reimburse the
Purchasers  for their legal fees and expenses  incurred in  connection  with the
preparation  and  negotiation  of the  Transaction  Documents  by paying to MZRL
$25,000 for the preparation and negotiation of the Transaction Documents (with a
credit for any retainer amounts paid on account thereof). At the Second Closing,
if any, the Company  shall  reimburse  the  Purchasers  for their legal fees and
expenses  incurred in connection  with the  preparation  and  negotiation of the
Transaction  Documents  by  paying  to  MZRL  $5,000  for  the  preparation  and
negotiation of the Transaction Documents (with a credit for any retainer amounts
paid on account thereof).  The amount contemplated by the immediately  preceding
sentence  shall be deducted from the Purchase Price and paid by the Purchaser to
MZRL and shall not be delivered  to the Company at the  Closing.  Other than the
amount contemplated herein and except as otherwise set forth in the Registration
Rights  Agreement,  each party shall pay the fees and expenses of its  advisers,
counsel,  accountants and other experts, if any, and all other expenses incurred
by such party incident to the negotiation,  preparation, execution, delivery and
performance of this  Agreement.  The Company shall pay all stamp and other taxes
and duties levied in connection with the issuance of the Securities.

         4.2 ENTIRE AGREEMENT;  AMENDMENTS. The Transaction Documents,  together
with the Exhibits and Schedules thereto and Transfer Agent Instructions, contain
the entire  understanding  of the parties  with  respect to the  subject  matter
hereof and supersede all prior agreements and  understandings,  oral or written,
with respect to such  matters,  which the parties  acknowledge  have been merged
into such documents, exhibits and schedules.

         4.3 NOTICES.  Any and all notices or other communications or deliveries
required or permitted to be provided  hereunder shall be in writing and shall be
deemed given and effective on the earliest of (i) the date of  transmission,  if
such  notice or  communication  is  delivered  via  facsimile  at the  facsimile
telephone  number  specified in this Section  prior to 6:30 p.m.  (New York City
time) on a Business Day,  (ii) the Business Day after the date of  transmission,
if such notice or  communication  is delivered  via  facsimile at the  facsimile
telephone number specified in this Agreement later than 6:30 p.m. (New York City
time) on any date and earlier than 11:59 p.m. (New York City time) on such date,
(iii) the Business Day following the date of mailing, if sent by U.S. nationally
recognized  overnight courier service,  or (iv) upon actual receipt by the party
to whom such notice is required  to be given.  The address for such  notices and
communications shall be as follows:

         If to the Company:     MacroChem Corporation
                                110 Hartwell Avenue
                                Lexington, MA 02421
                                Attn: Chief Financial Officer

         With a copy to:        Ropes & Gray
                                One  International Place
                                Boston, MA 02110-2624
                                Attn:  Dwight W. Quayle, Esq.

         If to a Purchaser:     To the address set forth under such
                                Purchaser's name on the signature pages hereto

or such other  address as may be designated  in writing  hereafter,  in the same
manner, by such Person.

         4.4 AMENDMENTS;  WAIVERS.  No provision of this Agreement may be waived
or amended except in a written  instrument  signed, in the case of an amendment,
by both the Company and each of the Purchasers  or, in the case of a waiver,  by
the party against whom  enforcement  of any such waiver is sought.  No waiver of
any default with respect to any  provision,  condition  or  requirement  of this
Agreement shall be deemed to be a continuing waiver in the future or a waiver of
any other  provision,  condition or requirement  hereof,  nor shall any delay or
omission of either  party to exercise any right  hereunder in any manner  impair
the exercise of any such right accruing to it thereafter.

         4.5  HEADINGS.  The headings  herein are for  convenience  only, do not
constitute a part of this  Agreement  and shall not be deemed to limit or affect
any of the provisions hereof.

         4.6  SUCCESSORS AND ASSIGNS.  This Agreement  shall be binding upon and
inure to the benefit of the parties and their successors and permitted  assigns.
The Company may not assign this Agreement or any rights or obligations hereunder
without  the prior  written  consent of the  Purchasers.  Except as set forth in
Section  3.1(a),  the  Purchasers  may not assign this  Agreement  or any of the
rights or  obligations  hereunder  without  the  consent  of the  Company.  This
provision  shall not limit  any  Purchaser's  right to  transfer  securities  or
transfer or assign rights under the Registration Rights Agreement.

         4.7  NO THIRD-PARTY  BENEFICIARIES.  This Agreement is intended for the
benefit of the parties  hereto and their  respective  successors  and  permitted
assigns and is not for the benefit of, nor may any provision  hereof be enforced
by, any other Person.

         4.8 GOVERNING  LAW. The corporate  laws of the State of Delaware  shall
govern  all  issues  concerning  the  relative  rights  of the  Company  and its
stockholders.  All  other  questions  concerning  the  construction,   validity,
enforcement  and  interpretation  of this  Agreement  shall be  governed  by and
construed and enforced in accordance  with the internal laws of the State of New
York,  without regard to the principles of conflicts of law thereof.  Each party
hereby  irrevocably  submits  to the  exclusive  jurisdiction  of the  state and
federal  courts sitting in the City of New York,  borough of Manhattan,  for the
adjudication  of any dispute  hereunder  or in  connection  herewith or with any
transaction  contemplated  hereby or discussed herein (including with respect to
the enforcement of the any of the Transaction Documents), and hereby irrevocably
waives,  and agrees not to assert in any suit,  action or proceeding,  any claim
that it is not personally  subject to the  jurisdiction of any such court,  that
such suit,  action or  proceeding  is improper.  Each party  hereby  irrevocably
waives  personal  service of process and consents to process being served in any
such suit,  action or  proceeding  by mailing a copy thereof via  registered  or
certified  mail or overnight  delivery (with evidence of delivery) to such party
at the address in effect for notices to it under this  Agreement and agrees that
such service shall constitute good and sufficient  service of process and notice
thereof.  Nothing contained herein shall be deemed to limit in any way any right
to serve process in any manner permitted by law.

         4.9 SURVIVAL. The representations, warranties, agreements and covenants
contained  herein shall survive the Closing and the delivery and exercise of the
Warrants for a period of five years.

         4.10  EXECUTION.  This  Agreement  may  be  executed  in  two  or  more
counterparts,  all of which when taken  together shall be considered one and the
same agreement and shall become effective when  counterparts have been signed by
each party and  delivered  to the other  party,  it being  understood  that both
parties need not sign the same  counterpart.  In the event that any signature is
delivered by facsimile  transmission,  such  signature  shall create a valid and
binding  obligation of the party executing (or on whose behalf such signature is
executed)  with the same force and effect as if such  facsimile  signature  page
were an original thereof.

         4.11  SEVERABILITY.  In case any one or more of the  provisions of this
Agreement  shall be invalid or  unenforceable  in any respect,  the validity and
enforceability of the remaining terms and provisions of this Agreement shall not
in any way be affected or impaired thereby and the parties will attempt to agree
upon a valid and enforceable  provision  which shall be a reasonable  substitute
therefor,  and upon so agreeing,  shall incorporate such substitute provision in
this Agreement.

         4.12  REMEDIES.  In addition to being  entitled to exercise  all rights
provided herein or granted by law,  including  recovery of damages,  each of the
Purchasers  will be entitled to specific  performance of the  obligations of the
Company under the Transaction Documents.  The Company and each of the Purchasers
agree  that  monetary  damages  may not be  adequate  compensation  for any loss
incurred by reason of any breach of its  obligations  described in the foregoing
sentence and hereby  agrees to waive in any action for specific  performance  of
any such obligation the defense that a remedy at law would be adequate.

         4.13  INDEPENDENT  NATURE OF PURCHASERS'  OBLIGATIONS  AND RIGHTS.  The
obligations of each Purchaser under any Transaction Document are several and not
joint with the  obligations  of any other  Purchaser  and no Purchaser  shall be
responsible  in any way for the  performance  of the  obligations  of any  other
Purchaser under any Transaction  Document.  Nothing  contained  herein or in any
Transaction  Document,  and no action taken by any Purchaser  pursuant  thereto,
shall be deemed to constitute the Purchasers as a partnership, an association, a
joint  venture  or any other kind of entity,  or create a  presumption  that the
Purchasers are in any way acting in concert with respect to such  obligations or
the transactions  contemplated by the Transaction Document. Each Purchaser shall
be entitled to independently  protect and enforce its rights,  including without
limitation  the  rights  arising  out of  this  Agreement  or  out of the  other
Transaction Documents,  and it shall not be necessary for any other Purchaser to
be joined as an additional party in any proceeding for such purpose.



<PAGE>
                  IN WITNESS  WHEREOF,  the  parties  hereto  have  caused  this
Securities Purchase Agreement to be duly executed by their respective authorized
signatories as of the date first indicated above.

                                                  MACROCHEM CORPORATION


                                              By:/s/Kenneth L. Rice, Jr.
                                              Name:  Kenneth L. Rice, Jr.
                                              Title: Chief Financial Officer






                   [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK
                      SIGNATURE PAGE FOR PURCHASER FOLLOWS]


<PAGE>

                                  BAY HARBOR INVESTMENTS, INC.



                                  By:/s/Kenneth L. Henderson
                                  Name:    Kenneth L. Henderson
                                  Title:   Attorney-In-Fact

                                  Purchase Price for Shares:          $4,500,000

                                  Number of Shares to be acquired:       908,329

                                  Warrant Shares subject to Closing
                                  Warrant:                               181,666

                                  Address for Notice:

                                  Bay Harbor Investments, Inc.
                                  c/o Gonzalez-Ruiz & Aleman (BVI) Limited
                                  Wickhams Cay I, Vanterpool Plaza
                                  P.O. Box 873
                                  Road Town, Tortolla. B.V.I.

                                  With a copy to:
                                  Morse, Zelnick, Rose & Lander LLP
                                  450 Park Avenue
                                  New York, New York 10022
                                  Fax No.:  212-838-9190
                                  Attn:  Kenneth S. Rose, Esq.

                                             And

                                  Cavallo Capital Corp.
                                  660 Madison Avenue
                                  New York, NY 10021
                                  Fax No: 212-651-9010
                                  Attn: Mr. Mor Sagi



<PAGE>



                                  STRONG RIVER INVESTMENTS, INC.



                                  By:/s/Kenneth L. Henderson
                                  Name:    Kenneth L. Henderson
                                  Title:   Attorney-In-Fact

                                  Purchase Price for Shares:          $4,500,000

                                  Number of Shares to be acquired:       908,329

                                  Warrant Shares subject to Closing
                                  Warrant:                               181,666


                                  Address for Notice:

                                  Strong River Investments, Inc.
                                  c/o Gonzalez-Ruiz & Aleman (BVI) Limited
                                  Wickhams Cay I, Vanterpool Plaza
                                  P.O. Box 873
                                  Road Town, Tortolla. B.V.I.

                                  With a copy to:
                                  Morse, Zelnick, Rose & Lander LLP
                                  450 Park Avenue
                                  New York, New York 10022
                                  Fax No.:  212-838-9190
                                  Attn:  Kenneth S. Rose, Esq.

                                             And

                                  Cavallo Capital Corp.
                                  660 Madison Avenue
                                  New York, NY 10021
                                  Fax No: 212-651-9010
                                  Attn: Mr. Mor Sagi



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