MACROCHEM CORP
8-K, EX-10, 2000-10-31
PHARMACEUTICAL PREPARATIONS
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NEITHER THESE  SECURITIES  NOR THE  SECURITIES  INTO WHICH THESE  SECURITIES ARE
EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE  COMMISSION OR
THE  SECURITIES  COMMISSION  OF ANY STATE IN  RELIANCE  UPON AN  EXEMPTION  FROM
REGISTRATION  UNDER SECURITIES ACT OF 1933, AS AMENDED (THE  "SECURITIES  ACT"),
AND,  ACCORDINGLY,  MAY NOT BE OFFERED OR SOLD EXCEPT  PURSUANT TO AN  EFFECTIVE
REGISTRATION  STATEMENT  UNDER THE  SECURITIES  ACT OR PURSUANT TO AN  AVAILABLE
EXEMPTION FROM THE REGISTRATION  REQUIREMENTS  THEREUNDER AND IN COMPLIANCE WITH
APPLICABLE STATE SECURITIES OR BLUE SKY LAWS.


                              MACROCHEM CORPORATION


                                     WARRANT

Warrant No. 5                                            Dated: October 23, 2000


         MacroChem Corporation,  a Delaware corporation (the "COMPANY"),  hereby
certifies  that, for value  received,  Leerink Swann & Company or its registered
assigns  ("HOLDER"),  is  entitled,  subject  to the terms set forth  below,  to
purchase from the Company up to a total of 108,999 shares of common stock,  $.01
par value per share (the "COMMON  STOCK"),  of the Company  (each such share,  a
"WARRANT SHARE" and all such shares,  the "WARRANT SHARES") at an exercise price
equal to $7.43 per share (as  adjusted  from time to time as provided in Section
8, the "EXERCISE  PRICE"),  at any time and from time to time from and after the
date hereof and through and including October 22, 2005 (the "EXPIRATION  DATE"),
and subject to the following terms and conditions.

                  1.  REGISTRATION  OF WARRANT.  The Company shall register this
Warrant,  upon  records to be  maintained  by the Company for that  purpose (the
"WARRANT REGISTER"),  in the name of the record Holder hereof from time to time.
The  Company  may deem and treat the  registered  Holder of this  Warrant as the
absolute owner hereof for the purpose of any exercise hereof or any distribution
to the Holder, and for all other purposes, and the Company shall not be affected
by notice to the contrary.

                  2.  REGISTRATION OF TRANSFERS AND EXCHANGES.

                      (a) The Company shall register the transfer of any portion
of this Warrant in the Warrant  Register,  upon surrender of this Warrant,  with
the Form of  Assignment  attached  hereto  duly  completed  and  signed,  to the
Transfer  Agent or to the Company at its address for notice set forth in Section
11. Upon any such  registration  or transfer,  a new warrant to purchase  Common
Stock, in substantially  the form of this Warrant (any such new warrant,  a "NEW
WARRANT"), evidencing the portion of this Warrant so transferred shall be issued
to the  transferee and a New Warrant  evidencing  the remaining  portion of this
Warrant not so transferred,  if any, shall be issued to the transferring Holder.
The acceptance of the New Warrant by the transferee  thereof shall be deemed the
acceptance of such  transferee of all of the rights and  obligations of a holder
of a Warrant.

                      (b) This  Warrant  is  exchangeable,  upon  the  surrender
hereof by the Holder to the office of the  Company at its address for notice set
forth in Section 11 for one or more New  Warrants,  evidencing  in the aggregate
the right to purchase  the number of Warrant  Shares which may then be purchased
hereunder. Any such New Warrant will be dated the date of such exchange.

                  3.  DURATION AND EXERCISE OF WARRANTS.

                      (a) This Warrant shall be  exercisable  by the  registered
Holder on any business day before 6:30 P.M., New York City time, at any time and
from time to time on or after the date hereof to and  including  the  Expiration
Date. At 6:30 P.M.,  New York City time on the  Expiration  Date, the portion of
this  Warrant not  exercised  prior  thereto  shall be and become void and of no
value.  The Company may not call or otherwise  redeem this  Warrant  without the
prior written consent of the Holder.

                      (b)  Upon  surrender  of this  Warrant,  with  the Form of
Election to Purchase  attached hereto duly completed and signed,  to the Company
at its  address  for  notice  set forth in  Section  12 and upon  payment of the
Exercise  Price  multiplied  by the  number of  Warrant  Shares  that the Holder
intends  to  purchase  hereunder,  in  the  manner  provided  hereunder,  all as
specified by the Holder in the Form of Election to Purchase,  the Company  shall
promptly  (but in no event later than three (3) business  days after the Date of
Exercise  (as  defined  herein))  issue or cause to be  issued  and  cause to be
delivered  to or upon the written  order of the Holder and in such name or names
as the Holder may designate,  a certificate for the Warrant Shares issuable upon
such  exercise,  free of  restrictive  legends except either in the event that a
registration  statement covering the resale of the Warrant Shares and naming the
Holder as a selling stockholder  thereunder is not then effective or the Warrant
Shares are not freely transferable without volume restrictions  pursuant to Rule
144(k) promulgated under the Securities Act of 1933, as amended (the "SECURITIES
ACT"). Any person so designated by the Holder to receive Warrant Shares shall be
deemed to have become holder of record of such Warrant  Shares as of the Date of
Exercise of this  Warrant.  The Company  shall,  upon request of the Holder,  if
available,   use  its  best  efforts  to  deliver   Warrant   Shares   hereunder
electronically  through the Depository Trust Corporation or another  established
clearing corporation performing similar functions.

                      A "DATE OF  EXERCISE"  means the date on which the Company
shall have received (i) this Warrant (or any New Warrant,  as applicable),  with
the Form of  Election  to  Purchase  attached  hereto (or  attached  to such New
Warrant)  appropriately  completed  and duly  signed,  and (ii)  payment  of the
Exercise  Price for the  number of  Warrant  Shares so  indicated  by the holder
hereof to be purchased.

                      (c) This  Warrant  shall  be  exercisable,  either  in its
entirety or, from time to time,  for a portion of the number of Warrant  Shares.
If less than all of the Warrant Shares which may be purchased under this Warrant
are exercised at any time, the Company shall issue or cause to be issued, at its
expense,  a New Warrant evidencing the right to purchase the remaining number of
Warrant Shares for which no exercise has been evidenced by this Warrant.

                  4. PIGGYBACK  REGISTRATION  RIGHTS.  If the Company intends to
file any  registration  statement with the  Securities  and Exchange  Commission
(other than  registration  statements  of the Company  filed on Form S-8 or Form
S-4, each as promulgated under the Securities Act, pursuant to which the Company
is  registering  securities  pursuant  to a  Company  employee  benefit  plan or
pursuant to a merger,  acquisition or similar transaction  including supplements
thereto,  but not additionally filed registration  statements in respect of such
securities)  at any time when there is not an effective  registration  statement
covering  the  resale of the  Warrant  Shares and naming the Holder as a selling
stockholder thereunder,  the Company shall provide the Holder with not less than
20-days notice of its intention to file such registration  statement and provide
the Holder the option to include  any or all of the  applicable  Warrant  Shares
therein,  subject to customary underwriter cutbacks applicable to all holders of
registration  rights.  The piggyback  registration  rights granted to the Holder
pursuant to this Section shall continue until all of the Holder's Warrant Shares
have been sold in accordance  with an effective  registration  statement or upon
the  Expiration  Date.  The  Company  will  pay  all  registration  expenses  in
connection therewith.

                  5.  PAYMENT OF TAXES.  The  Company  will pay all  documentary
stamp taxes  attributable to the issuance of Warrant Shares upon the exercise of
this Warrant;  provided,  however, that the Company shall not be required to pay
any tax  which  may be  payable  in  respect  of any  transfer  involved  in the
registration of any  certificates for Warrant Shares or Warrants in a name other
than that of the  Holder.  The  Holder  shall be  responsible  for all other tax
liability that may arise as a result of holding or transferring  this Warrant or
receiving Warrant Shares upon exercise hereof.

                  6. REPLACEMENT OF WARRANT. If this Warrant is mutilated, lost,
stolen or  destroyed,  the Company shall issue or cause to be issued in exchange
and  substitution  for  and  upon  cancellation   hereof,  or  in  lieu  of  and
substitution for this Warrant, a New Warrant,  but only upon receipt of evidence
reasonably  satisfactory  to the Company of such loss,  theft or destruction and
indemnity, if requested,  satisfactory to it. Applicants for a New Warrant under
such circumstances shall also comply with such other reasonable  regulations and
procedures and pay such other reasonable charges as the Company may prescribe.

                  7. RESERVATION OF WARRANT SHARES.  The Company  covenants that
it will at all times  reserve and keep  available  out of the  aggregate  of its
authorized but unissued  Common Stock,  solely for the purpose of enabling it to
issue  Warrant  Shares upon  exercise of this  Warrant as herein  provided,  the
number of  Warrant  Shares  which are then  issuable  and  deliverable  upon the
exercise of this entire Warrant, free from preemptive rights or any other actual
contingent purchase rights of persons other than the Holder (taking into account
the adjustments and  restrictions of Section 8). The Company  covenants that all
Warrant Shares that shall be so issuable and  deliverable  shall,  upon issuance
and the payment of the applicable  Exercise  Price in accordance  with the terms
hereof, be duly and validly authorized, issued and fully paid and nonassessable.

                  8. CERTAIN  ADJUSTMENTS.  The Exercise Price and the number of
Warrant Shares  issuable upon exercise of this Warrant are subject to adjustment
from time to time as set forth in this Section 8. Upon each such  adjustment  of
the Exercise Price pursuant to this Section 8, the Holder shall thereafter prior
to the Expiration Date be entitled to purchase,  at the Exercise Price resulting
from such  adjustment,  the number of Warrant Shares obtained by multiplying the
Exercise Price in effect  immediately  prior to such adjustment by the number of
Warrant Shares issuable upon exercise of this Warrant  immediately prior to such
adjustment and dividing the product thereof by the Exercise Price resulting from
such adjustment.

                      (a) If the  Company,  at any time  while  this  Warrant is
outstanding,  (i) shall pay a stock dividend (except scheduled dividends paid on
outstanding  preferred  stock  as of the  date  hereof  which  contain  a stated
dividend rate) or otherwise make a distribution  or  distributions  on shares of
its Common  Stock or on any other  class of capital  stock  payable in shares of
Common Stock,  (ii) subdivide  outstanding  shares of Common Stock into a larger
number of shares,  or (iii)  combine  outstanding  shares of Common Stock into a
smaller  number of shares,  the Exercise Price shall be multiplied by a fraction
of which the numerator shall be the number of shares of Common Stock  (excluding
treasury  shares,  if any)  outstanding  before  such  event  and of  which  the
denominator  shall be the number of shares of Common Stock  (excluding  treasury
shares,  if any)  outstanding  after such event. Any adjustment made pursuant to
this Section shall become  effective  immediately  after the record date for the
determination of stockholders  entitled to receive such dividend or distribution
and shall become effective immediately after the effective date in the case of a
subdivision  or  combination,  and shall apply to  successive  subdivisions  and
combinations.

                      (b) In case of any reclassification of the Common Stock or
any compulsory  share  exchange  pursuant to which the Common Stock is converted
into other  securities,  cash or property,  then the Holder shall have the right
thereafter  to  exercise  this  Warrant  only into the shares of stock and other
securities  and  property  receivable  upon or deemed to be held by  holders  of
Common Stock following such  reclassification or share exchange,  and the Holder
shall be  entitled  upon such  event to receive  such  amount of  securities  or
property  equal to the  amount of Warrant  Shares  such  Holder  would have been
entitled to had such Holder  exercised  this Warrant  immediately  prior to such
reclassification  or share exchange.  The terms of any such  reclassification or
share  exchange shall include such terms so as to continue to give to the Holder
the right to receive the  securities  or property set forth in this Section 8(b)
upon any exercise following any such reclassification or share exchange.

                      (c) If the  Company,  at any time  while  this  Warrant is
outstanding, shall distribute to all holders of Common Stock (and not to holders
of this Warrant)  evidences of its  indebtedness or assets or rights or warrants
to  subscribe  for or purchase  any  security  (excluding  those  referred to in
Sections 8(a), (b) and (d)),  then in each such case the Exercise Price shall be
determined by multiplying the Exercise Price in effect  immediately prior to the
record date fixed for  determination  of  stockholders  entitled to receive such
distribution by a fraction of which the denominator  shall be the Exercise Price
determined  as of the record date  mentioned  above,  and of which the numerator
shall be such Exercise Price on such record date less the then fair market value
at such record date of the portion of such assets or evidence of indebtedness so
distributed applicable to one outstanding share of Common Stock as determined by
the Company's  independent  certified public accountants that regularly examines
the financial statements of the Company (an "APPRAISER").

                      (d)  If  the  Company  or  any  subsidiary   thereof,   as
applicable with respect to Common Stock  Equivalents (as defined below),  at any
time while this  Warrant is  outstanding,  shall issue shares of Common Stock or
rights, warrants,  options or other securities or debt that are convertible into
or  exchangeable  for  shares  of Common  Stock  ("COMMON  STOCK  EQUIVALENTS"),
entitling any Person to acquire shares of Common Stock at a price per share less
than the lesser of (i) the then Per Share  Market  Value (as  defined in EXHIBIT
A), or (ii) the  Exercise  Price (if the  holder of the  Common  Stock or Common
Stock  Equivalent so issued shall at any time,  whether by operation of purchase
price adjustments, reset provisions,  floating conversion,  exercise or exchange
prices or otherwise, or due to warrants,  options or rights issued in connection
with such  issuance,  be entitled to receive  shares of Common  Stock at a price
less  than the  lesser  of (i) the  then Per  Share  Market  Value,  or (ii) the
Exercise Price, such issuance shall be deemed to have occurred for less than the
lesser of (i) the then Per Share  Market  Value,  or (ii) the  Exercise  Price),
then,  the Exercise  Price shall be multiplied  by a fraction,  the numerator of
which  shall be the  number of shares of Common  Stock  outstanding  immediately
prior to the  issuance  of such  shares of  Common  Stock or such  Common  Stock
Equivalents  plus the number of shares of Common Stock which the offering  price
for such shares of Common Stock or Common Stock  Equivalents  would  purchase at
the Exercise Price,  and the denominator of which shall be the sum of the number
of shares of Common Stock  outstanding  immediately  prior to such issuance plus
the number of shares of Common Stock so issued or issuable,  PROVIDED,  that for
purposes  hereof,  all shares of Common Stock that are issuable upon conversion,
exercise or exchange of Common  Stock  Equivalents  shall be deemed  outstanding
immediately after the issuance of such Common Stock Equivalents. Such adjustment
shall be made whenever  such shares of Common Stock or Common Stock  Equivalents
are issued.  However,  upon the expiration of any Common Stock  Equivalents  the
issuance of which  resulted in an adjustment in the Exercise  Price  pursuant to
this Section,  if any such Common Stock  Equivalents  shall expire and shall not
have been exercised,  the Exercise Price shall  immediately upon such expiration
be recomputed and effective immediately upon such expiration be increased to the
price  which it would have been (but  reflecting  any other  adjustments  in the
Exercise  Price  made  pursuant  to the  provisions  of this  Section  after the
issuance of such Common Stock  Equivalents)  had the  adjustment of the Exercise
Price made upon the issuance of such Common Stock  Equivalents  been made on the
basis of offering  for  subscription  or purchase  only that number of shares of
Common  Stock  actually  purchased  upon  the  exercise  of  such  Common  Stock
Equivalents  actually  exercised.  The  foregoing  shall  not  apply  to any (i)
issuances  of  securities  as  consideration  in  a  merger,   consolidation  or
acquisition of assets, or in connection with any strategic  partnership or joint
venture (the primary  purpose of which is not to raise  equity  capital),  or as
consideration  for the  acquisition  of a  business,  product  or license by the
Company,  (ii) the issuance of securities upon the exercise or conversion of the
Company's options,  warrants or other convertible  securities  outstanding as of
the date hereof,  including the Warrants  dated October 23, 2000,  issued to Bay
Harbor  Investments,  Inc., and the Warrants  dated October 23, 2000,  issued to
Strong River  Investments,  Inc., or (iii) the grant of options or warrants,  or
the issuance of additional  securities,  under any duly authorized Company stock
option, restricted stock plan or stock purchase plan.

                      (e) In case  of any (1)  merger  or  consolidation  of the
Company with or into  another  Person  other than a merger or  consolidation  in
which the Company is the  surviving  entity,  or (2) sale by the Company of more
than  one-half of the assets of the Company (on a book value  basis) in one or a
series of related transactions,  the Holder shall have the right, from and after
the date of such  merger,  sale or  consolidation,  as the  case may be,  to and
including the Expiration Date, exercise this Warrant for the shares of stock and
other  securities,  cash and  property  receivable  upon or deemed to be held by
holders of Common Stock  immediately  following  such merger,  consolidation  or
sale,  and the  Holder  shall be  entitled  upon such event or series of related
events to receive  such amount of  securities,  cash and  property as the Common
Stock for which this Warrant could have been exercised immediately prior to such
merger,  consolidation  or sales would have been entitled,  unless the acquiring
company  or newly  created  company  shall have paid the Holder the value of the
Warrant  determined on a Black-Scholes  basis. (For example,  if (1) the Company
merges with and into another Person ("NEWCO") and as a result thereof each share
of Common  Stock shall  entitle the holder  thereof to receive two shares of the
common stock of Newco and $2.00 in cash,  and (2) the  Exercise  Price is at the
effective time of such merger $6.00 per share,  then at all times thereafter and
prior to the Expiration  Date this Warrant shall upon the payment of $6.00 times
the number of Warrant  Shares  represent the right to receive (A) that number of
shares of the Common Stock of Newco as is equal to two times the Warrant Shares,
and (B) that  amount of cash as is equal to $2.00  times the  number of  Warrant
Shares.) The terms of any such merger,  sale or consolidation shall include such
terms so as to continue to give the Holder the right to receive the  securities,
cash and property set forth in this Section upon any  conversion  or  redemption
following such event.  This provision  shall  similarly apply to successive such
events.

                      (f) For the  purposes  of this  Section  8, the  following
clauses shall also be applicable:

                          (i)  RECORD  DATE.  In case the  Company  shall take a
record of the holders of its Common Stock for the purpose of entitling  them (A)
to  receive a  dividend  or other  distribution  payable  in Common  Stock or in
securities  convertible or  exchangeable  into shares of Common Stock, or (B) to
subscribe for or purchase Common Stock or securities convertible or exchangeable
into  shares of Common  Stock,  then such  record date shall be deemed to be the
date of the  issue or sale of the  shares of  Common  Stock  deemed to have been
issued or sold upon the declaration of such dividend or the making of such other
distribution  or the  date of the  granting  of such  right of  subscription  or
purchase, as the case may be.

                          (ii) TREASURY  SHARES.  The number of shares of Common
Stock outstanding at any given time shall not include shares owned or held by or
for the account of the Company,  and the disposition of any such shares shall be
considered an issue or sale of Common Stock.

                      (g) All calculations under this Section 8 shall be made to
the nearest cent or the nearest 1/100th of a share, as the case may be.

                      (h) If:

                          (i)   the  Company  shall  declare a dividend  (or any
                                other distribution) on its Common Stock; or

                          (ii)  the Company shall declare a special nonrecurring
                                cash  dividend on or a redemption  of its Common
                                Stock other than  pursuant to its current  stock
                                repurchase program and any extension thereof; or

                          (iii) the Company shall  authorize the granting to all
                                holders of the Common  Stock  rights or warrants
                                to  subscribe  for or  purchase  any  shares  of
                                capital stock of any class or of any rights; or

                          (iv)  the approval of any  stockholders of the Company
                                shall  be  required  in   connection   with  any
                                reclassification   of  the  Common  Stock,   any
                                consolidation  or merger to which the Company is
                                a  party,   any  sale  or  transfer  of  all  or
                                substantially  all of the assets of the Company,
                                or any  compulsory  share  exchange  whereby the
                                Common Stock is converted into other securities,
                                cash or property; or

                          (v)   the  Company   shall   authorize  the  voluntary
                                dissolution,  liquidation  or  winding up of the
                                affairs of the Company,

then the Company shall cause to be mailed to each Holder at their last addresses
as they shall appear upon the Warrant Register,  at least 20 calendar days prior
to the  applicable  record or effective  date  hereinafter  specified,  a notice
stating  (x) the date on which a record is to be taken for the  purpose  of such
dividend, distribution, redemption, rights or warrants, or if a record is not to
be taken,  the date as of which  the  holders  of  Common  Stock of record to be
entitled to such dividend, distributions,  redemption, rights or warrants are to
be  determined  or (y) the date on which such  reclassification,  consolidation,
merger,  sale,  transfer or share  exchange is expected to become  effective  or
close,  and the date as of which it is expected  that holders of Common Stock of
record  shall  be  entitled  to  exchange  their  shares  of  Common  Stock  for
securities,  cash or other  property  deliverable  upon  such  reclassification,
consolidation,  merger, sale, transfer, share exchange, dissolution, liquidation
or winding up;  PROVIDED,  HOWEVER,  that the failure to mail such notice or any
defect  therein or in the mailing  thereof  shall not affect the validity of the
corporate action required to be specified in such notice.

                  9.  PAYMENT  OF  EXERCISE  PRICE.  The  Holder  shall  pay the
Exercise Price in one of the following manners:


                      (a) CASH  EXERCISE.  The  Holder may  deliver  immediately
available funds; or


                      (b)  CASHLESS  EXERCISE.  The  Holder may  surrender  this
Warrant to the Company  together  with a notice of cashless  exercise,  in which
event the  Company  shall  issue to the  Holder  the  number of  Warrant  Shares
determined as follows:

                    X = Y [(A-B)/A]
         where:
                    X = the number of Warrant Shares to be issued to the Holder.

                    Y  =  the  number  of  Warrant  Shares  with respect to
                    which this Warrant is being exercised.

                    A = the average of the  closing  sale prices
                    of the Common Stock for the five (5) trading
                    days   immediately   prior   to   (but   not
                    including) the Date of Exercise.

                    B = the Exercise Price.

For purposes of Rule 144  promulgated  under the Securities Act, it is intended,
understood  and  acknowledged  that the  Warrant  Shares  issued  in a  cashless
exercise  transaction  shall be deemed to have been acquired by the Holder,  and
the  holding  period  for the  Warrant  Shares  shall  be  deemed  to have  been
commenced, on the issue date.

                  10.  FRACTIONAL  SHARES.  The Company shall not be required to
issue or cause to be issued  fractional  Warrant  Shares on the exercise of this
Warrant.  The number of full  Warrant  Shares  which shall be issuable  upon the
exercise of this Warrant shall be computed on the basis of the aggregate  number
of Warrant Shares  purchasable on exercise of this Warrant so presented.  If any
fraction of a Warrant Share would, except for the provisions of this Section, be
issuable on the  exercise of this  Warrant,  the Company  shall pay an amount in
cash equal to the Exercise Price multiplied by such fraction.

                  11. NOTICES.  Any and all notices or other  communications  or
deliveries hereunder shall be in writing and shall be deemed given and effective
on the earliest of (i) the date of transmission, if such notice or communication
is delivered via facsimile at the facsimile  telephone  number specified in this
Section  prior to 6:30 P.M.  (New York City  time) on a business  day,  (ii) the
business day after the date of transmission,  if such notice or communication is
delivered  via  facsimile at the facsimile  telephone  number  specified in this
Section  later than 6:30 P.M.  (New York City time) on any date and earlier than
11:59 P.M.  (New York City time) on such date,  (iii) the business day following
the date of mailing, if sent by nationally recognized overnight courier service,
or (iv) upon  actual  receipt by the party to whom such notice is required to be
given. The addresses for such communications shall be: (i) if to the Company, to
110 Hartwell Avenue, Lexington, MA 02421, facsimile:  (781) 862-4338,  attention
Chief Financial Officer,  or (ii) if to the Holder, to the Holder at the address
or facsimile  number  appearing on the Warrant Register or such other address or
facsimile  number as the Holder may  provide to the Company in  accordance  with
this Section.

                  12.  WARRANT  AGENT.  The Company shall serve as warrant agent
under this Warrant.  Upon thirty (30) days notice to the Holder, the Company may
appoint a new warrant agent.  Any corporation  into which the Company or any new
warrant agent may be merged or any corporation  resulting from any consolidation
to  which  the  Company  or any  new  warrant  agent  shall  be a  party  or any
corporation   to  which  the  Company  or  any  new  warrant   agent   transfers
substantially all of its corporate trust or shareholders services business shall
be a successor  warrant  agent under this  Warrant  without any further act. Any
such  successor  warrant agent shall  promptly cause notice of its succession as
warrant agent to be mailed (by first class mail,  postage prepaid) to the Holder
at the Holder's last address as shown on the Warrant Register.

                  13.  MISCELLANEOUS.


                      (a) This  Warrant  shall be  binding  on and  inure to the
benefit of the parties hereto and their respective  successors and assigns. This
Warrant may be amended only in writing  signed by the Company and the Holder and
their successors and assigns.

                      (b) Nothing in this Warrant  shall be construed to give to
any person or  corporation  other than the  Company  and the Holder any legal or
equitable right, remedy or cause under this Warrant. This Warrant shall inure to
the sole and exclusive benefit of the Company and the Holder.

                      (c) The  corporate  laws of the  State of  Delaware  shall
govern  all  issues  concerning  the  relative  rights  of the  Company  and its
stockholders.  All  other  questions  concerning  the  construction,   validity,
enforcement  and  interpretation  of  this  Warrant  shall  be  governed  by and
construed and enforced in accordance  with the internal laws of the State of New
York, without regard to the principles of conflicts of law thereof.  The Company
and the Holder hereby  irrevocably  submit to the exclusive  jurisdiction of the
state and federal courts sitting in the City of New York,  borough of Manhattan,
for the adjudication of any dispute hereunder or in connection  herewith or with
any transaction  contemplated hereby or discussed herein, and hereby irrevocably
waives,  and agrees not to assert in any suit,  action or proceeding,  any claim
that it is not personally subject to the jurisdiction of any such court, or that
such suit, action or proceeding is improper.  Each of the Company and the Holder
hereby  irrevocably  waives personal  service of process and consents to process
being served in any such suit,  action or proceeding by receiving a copy thereof
sent to the  Company  at the  address  in effect  for  notices  to it under this
instrument  and agrees that such service shall  constitute  good and  sufficient
service of process and notice thereof.  Nothing contained herein shall be deemed
to limit in any way any right to serve process in any manner permitted by law.

                      (d) The headings herein are for  convenience  only, do not
constitute a part of this Warrant and shall not be deemed to limit or affect any
of the provisions hereof.

                      (e) In case  any one or  more  of the  provisions  of this
Warrant  shall be invalid or  unenforceable  in any  respect,  the  validity and
enforceability  of the remaining  terms and provisions of this Warrant shall not
in any way be affected or impaired  thereby and the parties will attempt in good
faith  to  agree  upon a  valid  and  enforceable  provision  which  shall  be a
commercially  reasonable  substitute  therefor,  and  upon  so  agreeing,  shall
incorporate such substitute provision in this Warrant.


                  [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK,
                             SIGNATURE PAGE FOLLOWS]


<PAGE>

         IN WITNESS  WHEREOF,  the Company  has caused  this  Warrant to be duly
executed by its authorized officer as of the date first indicated above.

                                             MACROCHEM CORPORATION


                                             By: /s/Kenneth L. Rice, Jr.
                                             Name:   Kenneth L. Rice, Jr.
                                             Title:  Chief Financial Officer






<PAGE>
                          FORM OF ELECTION TO PURCHASE

(To be executed by the Holder to exercise the right to purchase shares of Common
Stock under the foregoing Warrant)

To MacroChem Corporation:

         In accordance  with the Warrant  enclosed with this Form of Election to
Purchase,  the undersigned hereby  irrevocably elects to purchase  _____________
shares of common stock, $.01 par value per share, of MacroChem  Corporation (the
"Common  Stock") and , if such Holder is not  utilizing  the  cashless  exercise
provisions  set forth in this  Warrant,  encloses  herewith  $________  in cash,
certified or official bank check or checks,  which sum  represents the aggregate
Exercise  Price (as defined in the  Warrant)  for the number of shares of Common
Stock to which this Form of  Election  to Purchase  relates,  together  with any
applicable taxes payable by the undersigned pursuant to the Warrant.

         The  undersigned  requests that  certificates  for the shares of Common
Stock issuable upon this exercise be issued in the name of


                                                PLEASE INSERT SOCIAL SECURITY OR
                                                TAX IDENTIFICATION NUMBER


                                                _______________________________


_______________________________________________________________________________
                         (Please print name and address)



         If the number of shares of Common  Stock  issuable  upon this  exercise
shall not be all of the shares of Common Stock which the undersigned is entitled
to purchase in accordance with the enclosed  Warrant,  the undersigned  requests
that a New Warrant (as defined in the Warrant)  evidencing the right to purchase
the shares of Common  Stock not  issuable  pursuant  to the  exercise  evidenced
hereby be issued in the name of and delivered to:

_______________________________________________________________________________
                         (Please print name and address)

_______________________________________________________________________________

_______________________________________________________________________________





Dated:____________,______              Name of Holder:


                                       (Print)_________________________________
                                       (By:)___________________________________
                                       (Name:)
                                       (Title:)
                                       (Signature must conform in all respects
                                       to name of holder as specified on the
                                       face of the Warrant)


<PAGE>

                               FORM OF ASSIGNMENT

           [To be completed and signed only upon transfer of Warrant]

         FOR VALUE RECEIVED, the undersigned hereby sells, assigns and transfers
unto  ________________________________  the  right  represented  by  the  within
Warrant to purchase ____________ shares of Common Stock of MacroChem Corporation
to which the within Warrant  relates and appoints  ________________  attorney to
transfer  said right on the books of  MacroChem  Corporation  with full power of
substitution in the premises.

Dated:

___________,_____


                                        _______________________________________
                                        (Signature must conform in all respects
                                        to name of holder as specified on the
                                        face of the Warrant)


                                        _______________________________________
                                        Address of Transferee

                                        _______________________________________

                                        _______________________________________



In the presence of:


___________________________________




<PAGE>


                                    EXHIBIT A

"PER SHARE MARKET VALUE" means on any particular  date (a) the closing bid price
per share of the Common  Stock on such date on the  Nasdaq or on any  Subsequent
Market on which the  Common  Stock is then  listed or  quoted,  as  reported  by
Bloomberg Information Services,  Inc. (or any successor entity succeeding to its
function of reporting  prices),  or if there is no such price on such date, then
the  closing  bid price on the Nasdaq or on such  Subsequent  Market on the date
nearest preceding such date, as reported by Bloomberg Information Services, Inc.
(or any successor entity succeeding to its function of reporting prices), or (b)
if the Common  Stock is not then listed or quoted on the Nasdaq or a  Subsequent
Market,   the   closing   bid  price  for  a  share  of  Common   Stock  in  the
over-the-counter   market,   as  reported  by  the  National   Quotation  Bureau
Incorporated or similar  organization  or agency  succeeding to its functions of
reporting  prices) at the close of business  on such date,  or (c) if the Common
Stock is not then reported by the National  Quotation  Bureau  Incorporated  (or
similar organization or agency succeeding to its functions of reporting prices),
then the average of the "Pink Sheet" quotes for the relevant  conversion period,
as  determined  in good faith by the Holder,  or (d) if the Common  Stock is not
then  publicly  traded  the fair  market  value of a share  of  Common  Stock as
determined  by an Appraiser  selected in good faith by the Holders of a majority
of the applicable Warrant Shares.


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