MACROCHEM CORP
8-K, EX-10, 2000-10-31
PHARMACEUTICAL PREPARATIONS
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                         REGISTRATION RIGHTS AGREEMENT

                  This Registration  Rights Agreement (this "AGREEMENT") is made
and entered into as of October 23, 2000, among MacroChem Corporation, a Delaware
corporation  (the  "COMPANY"),  and the  investors  signatory  hereto (each such
investor  is a  "PURCHASER"  and  all  such  investors  are,  collectively,  the
"PURCHASERS").

                  This  Agreement is made  pursuant to the  Securities  Purchase
Agreement, dated as of the date hereof among the Company and the Purchasers (the
"PURCHASE AGREEMENT").

                  The Company and the Purchasers hereby agree as follows:

         1.       DEFINITIONS

                  Capitalized  terms used and not otherwise  defined herein that
are defined in the Purchase  Agreement  shall have the meanings given such terms
in the Purchase Agreement. As used in this Agreement,  the following terms shall
have the following meanings:

                  "ADJUSTABLE  WARRANTS" shall have the meaning set forth in the
Purchase Agreement.

                  "AFFILIATE"  means,  with  respect  to any  Person,  any other
Person that directly or indirectly  controls or is controlled by or under common
control with such Person.  For the purposes of this definition,  "CONTROL," when
used with respect to any Person,  means the possession,  direct or indirect,  of
the power to direct or cause the  direction  of the  management  and policies of
such Person, whether through the ownership of voting securities,  by contract or
otherwise;  and the terms of "AFFILIATED,"  "CONTROLLING"  and "CONTROLLED" have
meanings correlative to the foregoing.

                  "BUSINESS DAY" means any day except  Saturday,  Sunday and any
day  which  shall be a legal  holiday  in the  United  States  or a day on which
banking  institutions in the State of New York are authorized or required by law
or other government actions to close.

                  "CLOSING  DATE"  shall  have  the  meaning  set  forth  in the
Purchase Agreement.

                  "CLOSING  WARRANTS"  shall have the  meaning  set forth in the
Purchase Agreement.

                  "COMMISSION" means the Securities and Exchange Commission.

                  "COMMON  STOCK" means the  Company's  common  stock,  $.01 par
value, or such securities that such stock shall hereafter be reclassified into.

                  "EFFECTIVENESS  DATE"  means,  with  respect  to  the  initial
Registration  Statement  required to be filed hereunder,  the 90th day following
the date of this  Agreement  and,  with respect to any  additional  Registration
Statements  which  may be  required  pursuant  to  Section  3(c),  the  90th day
following  the date that  notice  of the  requirement  to file  such  additional
Registration Statement is provided.

                  "EFFECTIVENESS  PERIOD"  shall have the  meaning  set forth in
Section 2(a).

                  "EXCHANGE ACT" means the  Securities  Exchange Act of 1934, as
amended.

                  "FILING  DATE" means the 30th day  following  the date of this
Agreement and, with respect to any additional  Registration Statements which may
be  required  pursuant to Section  3(c),  the 30th day  following  the date that
notice of the  requirement  to file such  additional  Registration  Statement is
provided.

                  "HOLDER" or "HOLDERS" means the holder or holders, as the case
may be, from time to time of Registrable Securities.

                  "INDEMNIFIED  PARTY"  shall  have  the  meaning  set  forth in
Section 5(c).

                  "INDEMNIFYING  PARTY"  shall  have the  meaning  set  forth in
Section 5(c).

                  "LOSSES" shall have the meaning set forth in Section 5(a).

                  "PERSON"  means an individual or a  corporation,  partnership,
trust,  incorporated  or  unincorporated  association,  joint  venture,  limited
liability  company,  joint stock company,  government (or an agency or political
subdivision thereof) or other entity of any kind.

                  "PROCEEDING" means an action,  claim,  suit,  investigation or
proceeding   (including,   without  limitation,   an  investigation  or  partial
proceeding, such as a deposition), whether commenced or threatened.

                  "PROSPECTUS" means the prospectus included in the Registration
Statement  (including,  without  limitation,  a  prospectus  that  includes  any
information  previously  omitted from a prospectus filed as part of an effective
registration  statement  in  reliance  upon  Rule  430A  promulgated  under  the
Securities Act), as amended or supplemented by any prospectus  supplement,  with
respect  to  the  terms  of  the  offering  of any  portion  of the  Registrable
Securities covered by the Registration  Statement,  and all other amendments and
supplements to the  Prospectus,  including  post-effective  amendments,  and all
material  incorporated by reference or deemed to be incorporated by reference in
such Prospectus.

                  "REGISTRABLE SECURITIES" means (i) the Shares, (ii) any shares
issuable on account of the Shares and (ii) the shares of Common  Stock  issuable
upon exercise in full of the Warrants.

                  "REGISTRATION  STATEMENT" means the registration statement and
any additional  registration  statements contemplated by Section 3(c), including
(in each case) the Prospectus,  amendments and supplements to such  registration
statement or  Prospectus,  including  pre- and  post-effective  amendments,  all
exhibits  thereto,  and all material  incorporated  by reference or deemed to be
incorporated by reference in such registration statement.

                  "RULE  144"  means  Rule  144  promulgated  by the  Commission
pursuant to the  Securities  Act, as such Rule may be amended from time to time,
or any similar rule or regulation  hereafter  adopted by the  Commission  having
substantially the same effect as such Rule.

                  "RULE  415"  means  Rule  415  promulgated  by the  Commission
pursuant to the  Securities  Act, as such Rule may be amended from time to time,
or any similar rule or regulation  hereafter  adopted by the  Commission  having
substantially the same effect as such Rule.

                  "RULE  424"  means  Rule  424  promulgated  by the  Commission
pursuant to the  Securities  Act, as such Rule may be amended from time to time,
or any similar rule or regulation  hereafter  adopted by the  Commission  having
substantially the same effect as such Rule.

                  "SECURITIES ACT" means the Securities Act of 1933, as amended,
and the rules and regulations promulgated thereunder.

                  "SHARES"  means  the  shares  of  Common  Stock  issued to the
Purchasers on the Closing Date pursuant to the Purchase Agreement.

                  "SPECIAL  COUNSEL"  means one special  counsel to the Holders,
for which the Holders will be reimbursed by the Company pursuant to Section 4.

                  "WARRANTS"  means  the  Closing  Warrants  and the  Adjustable
Warrants.

         2.       SHELF REGISTRATION

                  (a) On or prior to each Filing Date, the Company shall prepare
and file with the  Commission  a "Shelf"  Registration  Statement  covering  the
resale of all Registrable  Securities for an offering to be made on a continuous
basis  pursuant to Rule 415.  The  Registration  Statement  shall be on Form S-3
(except  if the  Company  is not  then  eligible  to  register  for  resale  the
Registrable  Securities on Form S-3, in which case such registration shall be on
another  appropriate form in accordance herewith as the Holders may consent) and
shall  contain  (except  if  otherwise  directed  by the  Holders)  the "Plan of
Distribution"   attached  hereto  as  ANNEX  A.  The  Company  shall  cause  the
Registration  Statement  to become  effective  and remain  effective as provided
herein.  The  Company  shall  use its best  efforts  to cause  the  Registration
Statement  to be  declared  effective  under the  Securities  Act as promptly as
possible after the filing thereof,  but in any event prior to the  Effectiveness
Date,  and  shall  use its best  efforts  to keep  such  Registration  Statement
continuously  effective  under the  Securities  Act until the date  which is two
years after the date that such Registration  Statement is declared  effective by
the Commission or such earlier date when all Registrable  Securities  covered by
such  Registration  Statement  have  been  sold  or may be sold  without  volume
restrictions pursuant to Rule 144(k) as determined by the counsel to the Company
pursuant to a written opinion letter to such effect, addressed and acceptable to
the  Company's  transfer  agent and the  affected  Holders  (the  "EFFECTIVENESS
PERIOD"),  PROVIDED,  that the Company shall not be deemed to have used its best
efforts to keep the Registration  Statement  effective during the  Effectiveness
Period if it  voluntarily  takes any action that would result in the Holders not
being  able to sell the  Registrable  Securities  covered  by such  Registration
Statement during the Effectiveness  Period, unless such action is required under
applicable  law or the  Company  has  filed a  post-effective  amendment  to the
Registration Statement and the Commission has not declared it effective.

                  (b) The initial  Registration  Statement to be filed hereunder
shall  include a number of shares of Common  Stock equal to no less than the sum
of (i) 200% of the number of shares  issuable  upon  exercise of the  Adjustable
Warrants  on the First  Vesting  Date (as  defined in the  Adjustable  Warrants)
assuming,  for the purposes of this subsection  that: (A) the First Vesting Date
occurs  on the  Closing  Date,  (B) the  Adjustment  Price  (as  defined  in the
Adjustable  Warrants)  is 60% of the Per Share  Market  Value (as defined in the
Adjustable  Warrant) for the Trading Day immediately  preceding the Closing Date
and (C) the  Applicable  Share  Number (as defined in the  Adjustable  Warrants)
equals the entire number of Shares purchased under the Purchase Agreement,  (ii)
the number of shares issuable upon exercise in full of the Closing  Warrants and
(iii) the Shares.

                  (c) If (a) the initial Registration  Statement is not filed on
or prior to the Filing Date (if the Company  files such  Registration  Statement
without  affording the Holder the  opportunity to review and comment on the same
as  required by Section  3(a)  hereof,  the Company  shall not be deemed to have
satisfied this clause (a)), or (b) the Company fails to file with the Commission
a request for  acceleration in accordance  with Rule 461  promulgated  under the
Securities  Act,  within  five days of the date  that the  Company  is  notified
(orally  or  in  writing,  whichever  is  earlier)  by  the  Commission  that  a
Registration Statement will not be "reviewed," or not subject to further review,
or (c) the  initial  Registration  Statement  filed  hereunder  is not  declared
effective by the Commission on or prior to the Effectiveness  Date, or (d) after
a Registration Statement is filed with and declared effective by the Commission,
such  Registration  Statement  ceases  to be  effective  as to  all  Registrable
Securities  at any time  prior to the  expiration  of the  Effectiveness  Period
without  being  succeeded  within ten days by an amendment to such  Registration
Statement  or by a  subsequent  Registration  Statement  filed with and declared
effective  by the  Commission,  or (e) the Common  Stock  shall be  delisted  or
suspended from trading on the Nasdaq  National  Market  ("NASDAQ") or on the New
York Stock  Exchange,  the American  Stock  Exchange or Nasdaq  SmallCap  Market
(each, a "SUBSEQUENT  MARKET") for more than three  consecutive  days, or (f) an
amendment  to a  Registration  Statement  is not filed by the  Company  with the
Commission  within ten days of the Commission's  notifying the Company that such
amendment  is required in order for such  Registration  Statement to be declared
effective  (any such failure or breach being  referred to as an "EVENT," and for
purposes  of clauses  (a) and (c) the date on which such  Event  occurs,  or for
purposes  of clause (b) the date on which such five day period is  exceeded,  or
for  purposes  of  clauses  (d) and (f) the date which  such ten  day-period  is
exceeded,  or for purposes of clause (e) the date on which such three day-period
is exceeded,  being referred to as "EVENT DATE"),  then, on each such Event Date
and every monthly  anniversary  thereof until the applicable Event is cured, the
Company  shall  pay to each  Holder an  amount  in cash or kind,  as  liquidated
damages and not as a penalty, equal to 2.0% of the aggregate purchase price paid
by such Holder pursuant to the Purchase  Agreement.  If the Company fails to pay
any liquidated  damages  pursuant to this Section in full within five days after
the date  payable,  the Company will pay  interest  thereon at a rate of 18% per
annum (or such lesser  maximum amount that is permitted to be paid by applicable
law) to the Holder, accruing daily from the date such liquidated damages are due
until  such  amounts,  plus all such  interest  thereon,  are paid in full.  The
liquidated  damages pursuant to the terms hereof shall apply on a pro-rata basis
for any portion of a month prior to the cure of an Event.

                  (d)  Notwithstanding  the  foregoing,  the Company may suspend
offers and sales or delay the  effectiveness of any Registration  Statement,  an
aggregate  of up to sixty  Trading  Days in any  12-month  period  (provided  no
suspension shall exceed twenty consecutive Trading Days), if the Company's Board
of Directors  determines,  in good faith,  that such delay would be necessary to
avoid premature disclosure of any material  acquisition,  disposition,  business
combination,  or other material  transaction,  and such delay or suspension will
not result in an Event hereunder.

         3.       REGISTRATION PROCEDURES

                  In  connection  with the  Company's  registration  obligations
hereunder, the Company shall:

                  (a) Not less than five  Business  Days  prior to the filing of
the  Registration  Statement  or any  related  Prospectus  or any  amendment  or
supplement  thereto,  the  Company  shall,  (i) furnish to the Holders and their
Special  Counsel  copies of all such documents  proposed to be filed  (including
those documents incorporated therein by reference which are not available on the
SEC EDGAR system), which documents will be subject to the review of such Holders
and their Special  Counsel,  and (ii) cause its officers and directors,  counsel
and  independent  certified  public  accountants to respond to such inquiries as
shall be necessary,  in the reasonable  opinion of Special  Counsel to conduct a
reasonable  investigation  within the meaning of the Securities Act. The Company
shall  not  file  the  Registration  Statement  or any  such  Prospectus  or any
amendments  or  supplements  thereto to which the  Holders of a majority  of the
Registrable Securities and their Special Counsel shall reasonably object, unless
required to do so by law in the opinion of Company Counsel.

                  (b) (i) Prepare and file with the Commission such  amendments,
including  post-effective  amendments,  to the  Registration  Statement  and the
Prospectus  used  in  connection  therewith  as may be  necessary  to  keep  the
Registration  Statement  continuously effective as to the applicable Registrable
Securities for the Effectiveness Period and prepare and file with the Commission
such  additional  Registration  Statements in order to register for resale under
the Securities  Act all of the  Registrable  Securities;  (ii) cause the related
Prospectus to be amended or supplemented by any required Prospectus  supplement,
and as so  supplemented  or  amended  to be filed  pursuant  to Rule 424;  (iii)
respond as promptly as reasonably possible, and in any event within ten days, to
any comments  received  from the  Commission  with  respect to the  Registration
Statement  or any  amendment  thereto  and as promptly  as  reasonably  possible
provide the Holders true and complete copies of all  correspondence  from and to
the Commission  relating to the Registration  Statement;  and (iv) comply in all
material respects with the provisions of the Securities Act and the Exchange Act
with respect to the  disposition of all  Registrable  Securities  covered by the
Registration  Statement  during the  applicable  period in  accordance  with the
intended  methods  of  disposition  by the  Holders  thereof  set  forth  in the
Registration Statement as so amended or in such Prospectus as so supplemented.

                  (c) File additional  Registration  Statements if the number of
Registrable Securities at any time exceeds 85% of the number of shares of Common
Stock then  registered  in a  Registration  Statement.  The  Company  shall have
fifteen  Business Days to file such  additional  Registration  Statements  after
notice of such requirement is given by the Holders.

                  (d) Notify the Holders of  Registrable  Securities  to be sold
and their Special  Counsel as promptly as reasonably  possible (and, in the case
of (i)(A) below, not less than three Business Days prior to such filing) and (if
requested by any such  Person)  confirm such notice in writing no later than one
Business  Day  following  the day (i)(A)  when a  Prospectus  or any  Prospectus
supplement or post-effective amendment to the Registration Statement is proposed
to be filed; (B) when the Commission  notifies the Company whether there will be
a "review" of such Registration  Statement and whenever the Commission  comments
in writing on such  Registration  Statement  (the Company shall provide true and
complete copies thereof and all written responses thereto to each of the Holders
if the subject matter relates to either this transaction or the Holder); and (C)
with respect to the Registration Statement or any post-effective amendment, when
the same has become  effective;  (ii) of any  request by the  Commission  or any
other Federal or state  governmental  authority for amendments or supplements to
the Registration Statement or Prospectus or for additional information; (iii) of
the issuance by the Commission of any stop order suspending the effectiveness of
the Registration  Statement covering any or all of the Registrable Securities or
the initiation of any Proceedings  for that purpose;  (iv) of the receipt by the
Company of any notification  with respect to the suspension of the qualification
or exemption from qualification of any of the Registrable Securities for sale in
any  jurisdiction,  or the  initiation or threatening of any Proceeding for such
purpose;  and (v) of the  occurrence  of any event or passage of time that makes
the financial  statements included in the Registration  Statement ineligible for
inclusion  therein  or any  statement  made  in the  Registration  Statement  or
Prospectus or any document  incorporated or deemed to be incorporated therein by
reference  untrue in any material  respect or that requires any revisions to the
Registration  Statement,  Prospectus or other  documents so that, in the case of
the  Registration  Statement or the Prospectus,  as the case may be, it will not
contain any untrue  statement  of a material  fact or omit to state any material
fact required to be stated therein or necessary to make the statements  therein,
in light of the circumstances under which they were made, not misleading.

                  (e) Use its best  efforts  to avoid the  issuance  of,  or, if
issued,  obtain the withdrawal of (i) any order suspending the  effectiveness of
the  Registration  Statement,  or (ii) any suspension of the  qualification  (or
exemption from  qualification) of any of the Registrable  Securities for sale in
any jurisdiction, at the earliest practicable moment.

                  (f) Furnish to each Holder and their Special Counsel,  without
charge,  at least one  conformed  copy of each  Registration  Statement and each
amendment thereto,  including financial statements and schedules,  all documents
incorporated or deemed to be incorporated therein by reference, and all exhibits
to the extent requested by such Person (including those previously  furnished or
incorporated by reference)  promptly after the filing of such documents with the
Commission.

                  (g) Promptly deliver to each Holder and their Special Counsel,
without charge, as many copies of the Prospectus or Prospectuses (including each
form of prospectus) and each amendment or supplement thereto as such Persons may
reasonably  request.  The Company hereby  consents to the use of such Prospectus
and each  amendment  or  supplement  thereto by each of the  selling  Holders in
connection with the offering and sale of the Registrable  Securities  covered by
such Prospectus and any amendment or supplement thereto.

                  (h) Prior to any public  offering of  Registrable  Securities,
use its best  efforts  to  register  or qualify or  cooperate  with the  selling
Holders  and their  Special  Counsel  in  connection  with the  registration  or
qualification  (or exemption from such  registration or  qualification)  of such
Registrable  Securities for offer and sale under the securities or Blue Sky laws
of such  jurisdictions  within  the  United  States as any  Holder  requests  in
writing,   to  keep  each  such  registration  or  qualification  (or  exemption
therefrom) effective during the Effectiveness Period and to do any and all other
acts or  things  necessary  or  advisable  to  enable  the  disposition  in such
jurisdictions of the Registrable Securities covered by a Registration Statement;
PROVIDED,  that the Company  shall not be required  to qualify  generally  to do
business in any  jurisdiction  where it is not then so  qualified or subject the
Company to any  material  tax in any such  jurisdiction  where it is not then so
subject.

                  (i)  Cooperate  with the  Holders  to  facilitate  the  timely
preparation and delivery of certificates  representing Registrable Securities to
be  delivered  to a  transferee  pursuant  to a  Registration  Statement,  which
certificates  shall be free, to the extent permitted by the Purchase  Agreement,
of all restrictive legends,  and to enable such Registrable  Securities to be in
such denominations and registered in such names as any such Holders may request.

                  (j) Upon the occurrence of any event  contemplated  by Section
3(d)(vi), as promptly as reasonably possible, prepare a supplement or amendment,
including  a  post-effective  amendment,  to  the  Registration  Statement  or a
supplement to the related  Prospectus or any document  incorporated or deemed to
be incorporated  therein by reference,  and file any other required  document so
that,  as  thereafter  delivered,  neither the  Registration  Statement nor such
Prospectus will contain an untrue  statement of a material fact or omit to state
a  material  fact  required  to be  stated  therein  or  necessary  to make  the
statements  therein,  in light of the circumstances  under which they were made,
not misleading.

                  (k) Comply with all  applicable  rules and  regulations of the
Commission.

                  (l) The Company may require each selling  Holder to furnish to
the Company a  certified  statement  as to the number of shares of Common  Stock
beneficially  owned by such Holder  and, if  requested  by the  Commission,  the
controlling person thereof.

         4.  REGISTRATION  EXPENSES.  All  fees  and  expenses  incident  to the
performance  of or compliance  with this Agreement by the Company shall be borne
by the Company  whether or not any  Registrable  Securities are sold pursuant to
the Registration  Statement.  The fees and expenses referred to in the foregoing
sentence shall include, without limitation, (i) all registration and filing fees
(including,  without  limitation,  fees and expenses (A) with respect to filings
required  to be made  with the  NASDAQ  and any  Subsequent  Market on which the
Common Stock is then listed for trading,  and (B) in compliance  with applicable
state securities or Blue Sky laws, (ii) printing  expenses  (including,  without
limitation, expenses of printing certificates for Registrable Securities), (iii)
messenger,  telephone  and delivery  expenses,  (iv) fees and  disbursements  of
counsel for the Company, (v) Securities Act liability insurance,  if the Company
so desires  such  insurance,  and (vi) fees and  expenses  of all other  Persons
retained by the Company in connection with the  consummation of the transactions
contemplated  by this Agreement.  In addition,  the Company shall be responsible
for all of its internal expenses incurred in connection with the consummation of
the transactions contemplated by this Agreement (including,  without limitation,
all salaries and expenses of its  officers  and  employees  performing  legal or
accounting  duties),  the expense of any annual  audit and the fees and expenses
incurred in  connection  with the listing of the  Registrable  Securities on any
securities exchange as required hereunder.

         5.       INDEMNIFICATION

                  (a)  INDEMNIFICATION  BY  THE  COMPANY.   The  Company  shall,
notwithstanding  any termination of this Agreement,  indemnify and hold harmless
each Holder,  the officers,  directors,  agents,  brokers (including brokers who
offer and sell  Registrable  Securities  as principal as a result of a pledge or
any failure to perform under a margin call of Common Stock), investment advisors
and employees of each of them,  each Person who controls any such Holder (within
the meaning of Section 15 of the  Securities  Act or Section 20 of the  Exchange
Act) and the officers,  directors, agents and employees of each such controlling
Person,  to the fullest extent permitted by applicable law, from and against any
and  all  losses,  claims,  damages,  liabilities,   costs  (including,  without
limitation,  reasonable costs of preparation and reasonable attorneys' fees) and
expenses (collectively,  "Losses"),  as incurred,  arising out of or relating to
any untrue or alleged  untrue  statement  of a material  fact  contained  in the
Registration  Statement,  any  Prospectus  or any form of  prospectus  or in any
amendment or supplement thereto or in any preliminary prospectus, or arising out
of or relating to any omission or alleged  omission of a material  fact required
to be stated therein or necessary to make the statements therein (in the case of
any  Prospectus or form of prospectus  or  supplement  thereto,  in light of the
circumstances under which they were made) not misleading,  except to the extent,
but only to the extent,  that (1) such untrue  statements or omissions are based
solely  upon  information  regarding  such  Holder  furnished  in writing to the
Company by such Holder  expressly  for use  therein,  or to the extent that such
information  relates  to  such  Holder  or  such  Holder's  proposed  method  of
distribution of Registrable  Securities and was reviewed and expressly  approved
in writing by such Holder expressly for use in the Registration Statement,  such
Prospectus or such form of Prospectus or in any amendment or supplement  thereto
(it being  understood  that the  Holder  has  approved  Annex A hereto  for this
purpose) or (2) in the case of an occurrence  of an event of the type  specified
in Section  3(d)(ii)-(vi),  the use by such Holder of an  outdated or  defective
Prospectus  after the  Company  has  notified  such  Holder in writing  that the
Prospectus  is outdated or defective  and prior to the receipt by such Holder of
the Advice  contemplated  in Section 6(e).  The Company shall notify the Holders
promptly of the institution,  threat or assertion of any Proceeding of which the
Company  is  aware in  connection  with the  transactions  contemplated  by this
Agreement.

                  (b) INDEMNIFICATION BY HOLDERS.  Each Holder shall,  severally
and not  jointly,  indemnify  and hold  harmless  the  Company,  its  directors,
officers, agents and employees, each Person who controls the Company (within the
meaning of Section 15 of the Securities Act and Section 20 of the Exchange Act),
and the directors, officers, agents or employees of such controlling Persons, to
the fullest extent  permitted by applicable law, from and against all Losses (as
incurred)  arising out of or based upon (x) such Holder's failure to comply with
the prospectus  delivery  requirements of the Securities Act, and (y) any untrue
statement  of a material  fact  contained  in any  Registration  Statement,  any
Prospectus,  or any  form  of  prospectus,  or in any  amendment  or  supplement
thereto,  or  arising  solely  out of or based  solely  upon any  omission  of a
material fact required to be stated  therein or necessary to make the statements
therein not misleading to the extent,  but only to the extent,  that such untrue
statement or omission is contained in any information so furnished in writing by
such Holder to the  Company  specifically  for  inclusion  in such  Registration
Statement or such Prospectus or to the extent that (1) such untrue statements or
omissions are based solely upon  information  regarding such Holder furnished in
writing to the  Company by such  Holder  expressly  for use  therein,  or to the
extent that such  information  relates to such Holder or such Holder's  proposed
method of distribution of Registrable  Securities and was reviewed and expressly
approved  in  writing  by such  Holder  expressly  for  use in the  Registration
Statement  (it being  understood  that the Holder has approved  Annex A for this
purpose),  such  Prospectus  or such form of  Prospectus  or in any amendment or
supplement  thereto or (2) in the case of an  occurrence of an event of the type
specified  in Section  3(d)(ii)-(vi),  the use by such  Holder of an outdated or
defective  Prospectus after the Company has notified such Holder in writing that
the  Prospectus is outdated or defective and prior to the receipt by such Holder
of the Advice  contemplated  in Section 6(e). In no event shall the liability of
any selling Holder  hereunder be greater in amount than the dollar amount of the
net proceeds received by such Holder upon the sale of the Registrable Securities
giving rise to such indemnification obligation.

                  (c) CONDUCT OF INDEMNIFICATION  PROCEEDINGS. If any Proceeding
shall be brought or asserted against any Person entitled to indemnity  hereunder
(an  "INDEMNIFIED  PARTY"),  such  Indemnified  Party shall promptly  notify the
Person from whom indemnity is sought (the "INDEMNIFYING  PARTY") in writing, and
the  Indemnifying  Party  shall  assume  the  defense  thereof,   including  the
employment of counsel  reasonably  satisfactory to the Indemnified Party and the
payment of all fees and expenses  incurred in connection  with defense  thereof;
provided,  that the failure of any  Indemnified  Party to give such notice shall
not relieve the Indemnifying Party of its obligations or liabilities pursuant to
this  Agreement,  except  (and  only) to the  extent  that it  shall be  finally
determined  by a court of competent  jurisdiction  (which  determination  is not
subject to appeal or further  review) that such failure  shall have  proximately
and materially adversely prejudiced the Indemnifying Party.

                  An Indemnified  Party shall have the right to employ  separate
counsel in any such  Proceeding and to participate in the defense  thereof,  but
the  fees  and  expenses  of  such  counsel  shall  be at the  expense  of  such
Indemnified  Party or Parties unless:  (1) the Indemnifying  Party has agreed in
writing to pay such fees and expenses;  or (2) the Indemnifying Party shall have
failed  promptly to assume the defense of such  Proceeding and to employ counsel
reasonably satisfactory to the Indemnified Party in any such Proceeding;  or (3)
the named  parties to any such  Proceeding  (including  any  impleaded  parties)
include  both  such  Indemnified  Party  and the  Indemnifying  Party,  and such
Indemnified Party shall have been advised by counsel that a conflict of interest
is likely to exist if the same counsel were to represent such Indemnified  Party
and the Indemnifying  Party (in which case, if such  Indemnified  Party notifies
the  Indemnifying  Party in writing that it elects to employ separate counsel at
the expense of the Indemnifying Party, the Indemnifying Party shall not have the
right to assume the defense  thereof and such counsel shall be at the expense of
the  Indemnifying  Party).  The  Indemnifying  Party shall not be liable for any
settlement of any such Proceeding  effected without its written  consent,  which
consent shall not be unreasonably withheld. No Indemnifying Party shall, without
the prior written consent of the Indemnified Party, effect any settlement of any
pending Proceeding in respect of which any Indemnified Party is a party,  unless
such settlement includes an unconditional release of such Indemnified Party from
all liability on claims that are the subject matter of such Proceeding.

                  All fees and  expenses  of the  Indemnified  Party  (including
reasonable  fees  and  expenses  to  the  extent  incurred  in  connection  with
investigating   or  preparing  to  defend  such   Proceeding  in  a  manner  not
inconsistent  with this  Section)  shall be paid to the  Indemnified  Party,  as
incurred, within ten Business Days of written notice thereof to the Indemnifying
Party  (regardless  of whether it is ultimately  determined  that an Indemnified
Party  is  not  entitled  to  indemnification  hereunder;   PROVIDED,  that  the
Indemnifying  Party may require such Indemnified Party to undertake to reimburse
all such fees and  expenses  to the extent it is finally  judicially  determined
that such Indemnified Party is not entitled to indemnification hereunder).

                  (d) CONTRIBUTION. If a claim for indemnification under Section
5(a) or 5(b) is unavailable to an Indemnified  Party (by reason of public policy
or  otherwise),  then each  Indemnifying  Party,  in lieu of  indemnifying  such
Indemnified  Party,  shall  contribute  to the  amount  paid or  payable by such
Indemnified  Party  as a  result  of  such  Losses,  in  such  proportion  as is
appropriate  to  reflect  the  relative  fault  of the  Indemnifying  Party  and
Indemnified  Party in connection with the actions,  statements or omissions that
resulted in such Losses as well as any other relevant equitable  considerations.
The relative fault of such  Indemnifying  Party and  Indemnified  Party shall be
determined by reference to, among other things,  whether any action in question,
including any untrue or alleged untrue  statement of a material fact or omission
or alleged omission of a material fact, has been taken or made by, or relates to
information  supplied by, such Indemnifying  Party or Indemnified Party, and the
parties'  relative intent,  knowledge,  access to information and opportunity to
correct or prevent  such  action,  statement  or  omission.  The amount  paid or
payable by a party as a result of any Losses shall be deemed to include, subject
to the limitations set forth in Section 5(c), any reasonable attorneys' or other
reasonable  fees or  expenses  incurred  by such  party in  connection  with any
Proceeding to the extent such party would have been indemnified for such fees or
expenses if the  indemnification  provided for in this Section was  available to
such party in accordance with its terms.

                  The  parties  hereto  agree  that it  would  not be  just  and
equitable if  contribution  pursuant to this Section 5(d) were determined by PRO
RATA  allocation  or by any other method of  allocation  that does not take into
account the equitable  considerations  referred to in the immediately  preceding
paragraph.  Notwithstanding the provisions of this Section 5(d), no Holder shall
be required to contribute,  in the aggregate, any amount in excess of the amount
by which the  proceeds  actually  received  by such  Holder from the sale of the
Registrable  Securities  subject  to the  Proceeding  exceeds  the amount of any
damages that such Holder has  otherwise  been  required to pay by reason of such
untrue or alleged untrue statement or omission or alleged omission.

                  The indemnity and  contribution  agreements  contained in this
Section are in addition to any liability that the Indemnifying  Parties may have
to the Indemnified Parties.

         6.       MISCELLANEOUS

                  (a) REMEDIES.  In the event of a breach by the Company or by a
Holder,  of any of their  obligations  under this Agreement,  each Holder or the
Company,  as the case may be, in  addition to being  entitled  to  exercise  all
rights granted by law and under this Agreement,  including  recovery of damages,
will be entitled to specific performance of its rights under this Agreement. The
Company and each Holder agree that monetary  damages would not provide  adequate
compensation  for any losses  incurred by reason of a breach by it of any of the
provisions of this Agreement and hereby further agrees that, in the event of any
action for specific  performance  in respect of such breach,  it shall waive the
defense that a remedy at law would be adequate.

                  (b) NO INCONSISTENT  AGREEMENTS.  The Company has not entered,
as of the date  hereof,  nor  shall  the  Company,  on or after the date of this
Agreement,  enter into any  agreement  with  respect to its  securities  that is
inconsistent  with the  rights  granted  to the  Holders  in this  Agreement  or
otherwise  conflicts  with the  provisions  hereof.  Except as and to the extent
specified in SCHEDULE 6(B) hereto,  the Company has not previously  entered into
any  agreement  granting  any  registration  rights  with  respect to any of its
securities to any Person which have not been fully satisfied.

                  (c) NO PIGGYBACK ON REGISTRATIONS. Except as and to the extent
specified in SCHEDULE  6(C) hereto,  neither the Company nor any of its security
holders  (other than the Holders in such capacity  pursuant  hereto) may include
securities  of  the  Company  in  the  Registration  Statement  other  than  the
Registrable  Securities,  and the Company  shall not after the date hereof enter
into any agreement providing any such right to any of its security holders.

                  (d) COMPLIANCE.  Each Holder covenants and agrees that it will
comply  with the  prospectus  delivery  requirements  of the  Securities  Act as
applicable to it in connection with sales of Registrable  Securities pursuant to
the Registration Statement.

                   (e)  DISCONTINUED  DISPOSITION.  Each  Holder  agrees  by its
acquisition of such  Registrable  Securities that, upon receipt of a notice from
the Company of the  occurrence  of any event of the kind  described  in Sections
2(d),  3(d)(ii),  3(d)(iii),  3(d)(iv),  3(d)(v) or  3(d)(vi),  such Holder will
forthwith  discontinue  disposition  of such  Registrable  Securities  under the
Registration  Statement  until  such  Holder's  receipt  of  the  copies  of the
supplemented  Prospectus and/or amended Registration  Statement  contemplated by
Section  3(j),  or until it is advised in writing (the  "ADVICE") by the Company
that the use of the applicable  Prospectus may be resumed,  and, in either case,
has  received  copies  of  any  additional  or  supplemental  filings  that  are
incorporated  or deemed to be  incorporated  by reference in such  Prospectus or
Registration  Statement.  The  Company may  provide  appropriate  stop orders to
enforce the provisions of this paragraph.

                  (f)  PIGGY-BACK  REGISTRATIONS.  If at  any  time  during  the
Effectiveness Period there is not an effective  Registration  Statement covering
all of the Registrable Securities and the Company shall determine to prepare and
file with the  Commission a registration  statement  relating to an offering for
its own account or the account of others under the  Securities Act of any of its
equity securities, other than on Form S-4 or Form S-8 (each as promulgated under
the Securities Act) or their then equivalents  relating to equity  securities to
be issued solely in connection with any acquisition of any entity or business or
equity  securities  issuable in connection  with stock option or other  employee
benefit plans, then the Company shall send to each Holder written notice of such
determination and, if within fifteen days after receipt of such notice, any such
Holder  shall  so  request  in  writing,  the  Company  shall  include  in  such
registration  statement  all or any  part of such  Registrable  Securities  such
holder  requests to be  registered,  subject to customary  underwriter  cutbacks
applicable to all holders of registration rights.

                  (g) AMENDMENTS AND WAIVERS.  The provisions of this Agreement,
including  the  provisions  of this  sentence,  may not be amended,  modified or
supplemented,  and waivers or consents to departures from the provisions  hereof
may not be given,  unless the same shall be in writing and signed by the Company
and the  Holders  of at least  two-thirds  of the then  outstanding  Registrable
Securities.  Notwithstanding  the foregoing,  a waiver or consent to depart from
the provisions  hereof with respect to a matter that relates  exclusively to the
rights of certain  Holders and that does not directly or  indirectly  affect the
rights of other  Holders  may be given by Holders of at least a majority  of the
Registrable  Securities  to which  such  waiver or  consent  relates;  PROVIDED,
HOWEVER,  that the provisions of this sentence may not be amended,  modified, or
supplemented  except  in  accordance  with  the  provisions  of the  immediately
preceding sentence.

                  (h) NOTICES.  Any and all notices or other  communications  or
deliveries  required or permitted to be provided  hereunder  shall be in writing
and  shall be deemed  given and  effective  on the  earliest  of (i) the date of
transmission,  if such notice or communication is delivered via facsimile at the
facsimile  telephone  number  specified in this Section  prior to 6:30 p.m. (New
York City  time) on a  Business  Day,  (ii) the  Business  Day after the date of
transmission,  if such notice or communication is delivered via facsimile at the
facsimile telephone number specified in this Agreement later than 6:30 p.m. (New
York City time) on any date and earlier than 11:59 p.m.  (New York City time) on
such date, (iii) the Business Day following the date of mailing, if sent by U.S.
nationally  recognized overnight courier service, or (iv) upon actual receipt by
the party to whom such  notice is  required  to be given.  The  address for such
notices and communications shall be as follows:

         If to the Company:    MacroChem Corporation
                               110 Hartwell Avenue
                               Lexington, MA 02421
                               Attn: Chief Financial Officer

         With copies to:       Ropes & Gray
                               One International Place
                               Boston, MA 02110-2624
                               Attn:  Dwight W. Quayle, Esq.

         If                    to  a  Purchaser:   To  the
                               address   set  forth  under
                               such  Purchaser's  name  on
                               the signature pages hereto.

         If to any other Person who is then the registered Holder:

                               To the  address  of such  Holder  as it  appears
                               in the stock transfer books of the Company

or such other  address as may be designated  in writing  hereafter,  in the same
manner, by such Person.

                  (i) SUCCESSORS AND ASSIGNS.  This Agreement shall inure to the
benefit of and be binding upon the successors  and permitted  assigns of each of
the parties and shall inure to the benefit of each  Holder.  The Company may not
assign its rights or obligations  hereunder without the prior written consent of
each Holder.  Each Holder may assign their  respective  rights  hereunder in the
manner and to the Persons as permitted under the Purchase Agreement.

                  (j) COUNTERPARTS. This Agreement may be executed in any number
of  counterparts,  each of  which  when so  executed  shall be  deemed  to be an
original  and, all of which taken  together  shall  constitute  one and the same
Agreement.   In  the  event  that  any   signature  is  delivered  by  facsimile
transmission,  such  signature  shall create a valid  binding  obligation of the
party  executing  (or on whose behalf such  signature is executed) the same with
the same  force and  effect as if such  facsimile  signature  were the  original
thereof.

                  (k) GOVERNING LAW. All questions  concerning the construction,
validity,  enforcement and interpretation of this Agreement shall be governed by
and construed and enforced in accordance  with the internal laws of the State of
New York,  without  regard to the  principles of conflicts of law thereof.  Each
party hereby irrevocably submits to the exclusive  jurisdiction of the state and
federal  courts sitting in the City of New York,  borough of Manhattan,  for the
adjudication  of any dispute  hereunder  or in  connection  herewith or with any
transaction  contemplated  hereby or discussed  herein,  and hereby  irrevocably
waives,  and agrees not to assert in any suit,  action or proceeding,  any claim
that it is not personally  subject to the  jurisdiction of any such court,  that
such suit,  action or  proceeding  is improper.  Each party  hereby  irrevocably
waives  personal  service of process and consents to process being served in any
such suit,  action or  proceeding by mailing a copy thereof to such party at the
address in effect for  notices to it under this  Agreement  and agrees that such
service  shall  constitute  good and  sufficient  service of process  and notice
thereof.  Nothing contained herein shall be deemed to limit in any way any right
to serve process in any manner permitted by law.

                  (l)  CUMULATIVE  REMEDIES.  The remedies  provided  herein are
cumulative and not exclusive of any remedies provided by law.

                  (m)  SEVERABILITY.   If  any  term,  provision,   covenant  or
restriction of this Agreement is held by a court of competent jurisdiction to be
invalid, illegal, void or unenforceable, the remainder of the terms, provisions,
covenants  and  restrictions  set forth  herein  shall  remain in full force and
effect and shall in no way be affected, impaired or invalidated, and the parties
hereto  shall use their  reasonable  efforts to find and  employ an  alternative
means to achieve the same or substantially  the same result as that contemplated
by such term,  provision,  covenant or restriction.  It is hereby stipulated and
declared to be the  intention of the parties  that they would have  executed the
remaining terms, provisions, covenants and restrictions without including any of
such that may be hereafter declared invalid, illegal, void or unenforceable.

                  (n)  HEADINGS.   The  headings  in  this   Agreement  are  for
convenience  of  reference  only and  shall not limit or  otherwise  affect  the
meaning hereof.

                  (o) SHARES HELD BY THE COMPANY  AND ITS  AFFILIATES.  Whenever
the  consent or approval of Holders of a  specified  percentage  of  Registrable
Securities is required hereunder,  Registrable Securities held by the Company or
its  Affiliates  (other than any Holder or  transferees or successors or assigns
thereof  if such  Holder is deemed  to be an  Affiliate  solely by reason of its
holdings of such  Registrable  Securities)  shall not be counted in  determining
whether  such  consent or  approval  was given by the  Holders of such  required
percentage.

                  (p) INDEPENDENT NATURE OF PURCHASERS'  OBLIGATIONS AND RIGHTS.
The  obligations of each  Purchaser  hereunder is several and not joint with the
obligations  of any  other  Purchaser  hereunder,  and  no  Purchaser  shall  be
responsible  in any way for the  performance  of the  obligations  of any  other
Purchaser  hereunder.  Nothing  contained  herein or in any other  agreement  or
document delivered at any closing, and no action taken by any Purchaser pursuant
hereto  or  thereto,   shall  be  deemed  to  constitute  the  Purchasers  as  a
partnership,  an  association,  a joint venture or any other kind of entity,  or
create a presumption  that the  Purchasers are in any way acting in concert with
respect to such obligations or the transactions  contemplated by this Agreement.
Each  Purchaser  shall be entitled to protect and enforce its rights,  including
without limitation the rights arising out of this Agreement, and it shall not be
necessary  for any other  Purchaser to be joined as an  additional  party in any
proceeding for such purpose.


                   [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK
                           SIGNATURE PAGES TO FOLLOW]


<PAGE>

                  IN  WITNESS   WHEREOF,   the  parties   have   executed   this
Registration Rights Agreement as of the date first written above.

                                        MACROCHEM CORPORATION


                                        By:/s/Kenneth L. Rice, Jr.
                                        Name:   Kenneth L. Rice, Jr.
                                        Title:  Chief Financial Officer






                   [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK
                     SIGNATURE PAGES OF PURCHASER TO FOLLOW]


<PAGE>

                          BAY HARBOR INVESTMENTS, INC.


                          By:/s/ Kenneth L. Henderson
                          Name:    Kenneth L. Henderson
                          Title:   Attorney-In-Fact


                          Address for Notice:

                          Bay Harbor Investments, Inc.
                          c/o Gonzalez-Ruiz & Aleman (BVI) Limited
                          Wickhams Cay I, Vanterpool Plaza
                          P.O. Box 873
                          Road Town, Tortolla, BVI

                          With copies to:
                          Morse, Zelnick, Rose & Lander LLP
                          450 Park Avenue
                          New York, New York 10022
                          Attn:  Kenneth S. Rose, Esq.

                                       And

                          Cavallo Capital Corp.
                          660 Madison Avenue
                          New York, NY 10021
                          Fax No: 212-651-9010
                          Attn: Mr. Mor Sagi


<PAGE>


                         STRONG RIVER INVESTMENTS, INC.


                         By:/s/Kenneth L. Henderson
                         Name:    Kenneth L. Henderson
                         Title:   Attorney-In-Fact


                         Address for Notice:

                         Strong River Investments, Inc.
                         c/o Gonzalez-Ruiz & Aleman (BVI) Limited
                         Wickhams Cay I, Vanterpool Plaza
                         P.O. Box 873
                         Road Town, Tortolla, BVI

                         With copies to:
                         Morse, Zelnick, Rose & Lander LLP
                         450 Park Avenue
                         New York, New York 10022
                         Attn:  Kenneth S. Rose, Esq.

                                       And

                         Cavallo Capital Corp.
                         660 Madison Avenue
                         New York, NY 10021
                         Fax No: 212-651-9010
                         Attn: Mr. Mor Sagi



<PAGE>
                                                                       ANNEX A

                              PLAN OF DISTRIBUTION


      The  Selling  Stockholders  and  any  of  their  pledgees,  assignees  and
successors-in-interest  may, from time to time,  sell any or all of their shares
of Common Stock on any stock exchange,  market or trading  facility on which the
shares  are traded or in private  transactions.  These  sales may be at fixed or
negotiated  prices.  The  Selling  Stockholders  may  use any one or more of the
following methods when selling shares:

          o    ordinary  brokerage  transactions  and  transactions in which the
               broker-dealer solicits purchasers;

          o    block trades in which the broker-dealer  will attempt to sell the
               shares  as agent but may  position  and  resell a portion  of the
               block as principal to facilitate the transaction;

          o    purchases  by a  broker-dealer  as  principal  and  resale by the
               broker-dealer for its account;

          o    an  exchange  distribution  in  accordance  with the rules of the
               applicable exchange;

          o    privately negotiated transactions;

          o    short sales

          o    broker-dealers may agree with the Selling  Stockholders to sell a
               specified number of such shares at a stipulated price per share;

          o    a combination of any such methods of sale; and

          o    any other method permitted pursuant to applicable law.

         The Selling  Stockholders may also sell shares under Rule 144 under the
Securities Act, if available, rather than under this prospectus.

         Broker-dealers  engaged by the  Selling  Stockholders  may  arrange for
other  brokers-dealers  to  participate  in sales.  Broker-dealers  may  receive
commissions or discounts from the Selling Stockholders (or, if any broker-dealer
acts as agent for the purchaser of shares,  from the purchaser) in amounts to be
negotiated.  The  Selling  Stockholders  do not  expect  these  commissions  and
discounts to exceed what is customary in the types of transactions involved.

         The  Selling  Stockholders  and any  broker-dealers  or agents that are
involved  in selling  the shares may be deemed to be  "underwriters"  within the
meaning of the Securities Act in connection with such sales. In such event,  any
commissions  received  by such  broker-dealers  or agents  and any profit on the
resale  of the  shares  purchased  by  them  may be  deemed  to be  underwriting
commissions or discounts under the Securities Act.

         The Company is required  to pay all fees and  expenses  incident to the
registration  of the shares.  The Company  has agreed to  indemnify  the Selling
Stockholders against certain losses, claims, damages and liabilities,  including
liabilities under the Securities Act.


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