BIOMATRIX INC, 10-K, 1998-03-30

BIOMATRIX INC
10-K, 1998-03-30
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)

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SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549

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FORM 10-K

ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF
THE SECURITIES EXCHANGE ACT OF 1934

FOR THE FISCAL YEAR ENDED DECEMBER 31, 1997 COMMISSION FILE NUMBER 0-19373

--------------------

BIOMATRIX, INC.
(Exact name of registrant as specified in its charter)

<TABLE>
<CAPTION>
DELAWARE (201) 945-9550 13-3058261
<S> <C> <C>
(State of other jurisdiction of (Registrant's telephone number, (IRS Employer
incorporation or organization) including area code) Identification No.)
</TABLE>

65 Railroad Avenue
Ridgefield, N.J. 07657
(Address of principal executive offices) (Zip Code)

--------------------

SECURITIES REGISTERED PURSUANT TO SECTION 12(b) OF THE ACT:

None

SECURITIES REGISTERED PURSUANT TO SECTION 12(g) OF THE ACT:
Common Stock. $.0001 Par Value
(Title of Class)

Name of exchange on which registered shares are traded: Nasdaq National
Market

Indicate by check mark whether the registrant (1) has filed all reports
required to be filed by Section 13 or 15(d) of the Securities Exchange Act 1934
during preceding 12 months (or for such shorter period that the registrant was
required to file such reports), and (2) has been subject to such filing
requirements for the past 90 days.

Yes X No
----- -------

Indicate by check mark if disclosure of delinquent filers pursuant to
Item-405 of Regulation S-K is not contained herein, and will not be contained,
to the best of registrant's knowledge, in definitive proxy or information
statements incorporated by reference in Part III of this Form 10-K or any
amendment to this Form 10-K [ ].

The aggregate market value of the voting stock held by non-affiliates
of the registrant as of March 2, 1998, was approximately $216,113,196, based
upon the last reported sales price of the registrant's Common Stock on the
Nasdaq National Market.

At March 2, 1998 there were 11,010,338 shares of the registrant's
Common Stock outstanding.
--------------------

DOCUMENTS INCORPORATED BY REFERENCE

Portions of the Proxy Statement relating to the Annual Meeting of
Shareholders to be held on May 29, 1998, are incorporated by reference into Part
III of this report. Other documents incorporated by reference are listed in the
Exhibit Index.
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BIOMATRIX, INC.

1997 ANNUAL REPORT - FORM 10-K

TABLE OF CONTENTS

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Item No. Page
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Part I
1. Business..........................................................................................1
Overview........................................................................................1
Therapeutics....................................................................................2
Therapeutics In Development.....................................................................4
Skin Care Products..............................................................................4
Distribution Agreements.........................................................................5
Government Loan.................................................................................7
Manufacturing...................................................................................7
Human Resources.................................................................................7
Research and Development Expenditures...........................................................7
Sales by Geographic Area and Significant Customer Data..........................................7
Risk Factors....................................................................................8
2. Properties.......................................................................................10
3. Legal Proceedings................................................................................10
4. Submission of Matters to a Vote of Security Holders..............................................11
Executive Officers...............................................................................11
Part II
5. Market for the Registrant's Common Equity and Related Shareholder Matters........................12
6. Selected Financial Data..........................................................................13
7. Management's Discussion and Analysis of Financial Condition and Results of
Operations.......................................................................................14
8. Financial Statements and Supplementary Data......................................................17
9. Changes In and Disagreements with Accountants on Accounting and Financial
Disclosure.......................................................................................17
Part III
10. Directors and Executive Officers of the Registrant...............................................17
11. Executive Compensation...........................................................................17
12. Security Ownership of Certain Beneficial Owners and Management...................................17
13. Certain Relationships and Related Transactions...................................................17
Part IV
14. Exhibits, Financial Statement Schedules and Reports on Form 8-K..................................18
</TABLE>
<PAGE> 3
PART I

ITEM 1. BUSINESS

OVERVIEW

Biomatrix, Inc., together with its subsidiaries Biomatrix Medical
Canada Inc. ("BMC"), Biomatrix Svenska AB ("Biomatrix Svenska"), Biomatrix U.K.
Limited ("Biomatrix UK"), Biomatrix Hong Kong Limited ("Biomatrix Hong Kong"),
Biomatrix France SARL ("Biomatrix France"), and Biomatrix Switzerland GmbH
("Biomatrix Switzerland") (together, "Biomatrix" or the "Company") develops,
manufactures, markets and sells a series of proprietary viscoelastic products
made of biological polymers called hylans for use in therapeutic medical
applications and skin care. Hylans are chemically modified forms of the
naturally occurring hyaluronan (also known as hyaluronic acid or sodium
hyaluronate). Hylans are the second generation of viscoelastics used in
medicine, and are characterized by significantly enhanced physical (rheological)
properties (elasticity, viscosity and pseudoplasticity) as compared to naturally
occurring hyaluronan, from which the first generation viscoelastics are made.
The discovery of hylans has allowed the Company to develop a range of patented
products with superior viscoelastic properties in the forms of fluids, gels and
solids.

The Company was founded in 1981. In 1983, the Company established its
research and development department, laboratory facilities and a pilot
manufacturing plant at its corporate headquarters in Ridgefield, New Jersey.
During the period from 1987 through 1995, the Company also conducted research
and development work in Europe through its wholly owned subsidiary Biomatrix
Svenska in Uppsala, Sweden. BMC was established in 1991 to manufacture medical
products and to market certain medical products in Canada. In 1997, Biomatrix
UK, Biomatrix Switzerland and Biomatrix Hong Kong were established to market and
sell certain medical products in the United Kingdom, Switzerland, and Hong Kong,
respectively. Biomatrix France was also established in 1997 to assist in
marketing certain products in France.

The Company believes that it is distinguished from other companies in
the field by its association with Dr. Endre A. Balazs, a co-founder and current
Chief Executive Officer and Chief Scientific Officer of the Company, who has
authored numerous publications on the medical applications of hyaluronan based
viscoelastic products. Prior to the organization of the Company, Dr. Balazs
invented the use of hyaluronan in medicine and developed the first generation
hyaluronan based viscoelastics used in medicine worldwide. These products were
based on a highly purified fraction of the unmodified, naturally occurring
hyaluronan. In 1993, the Company obtained the rights from Dr. Balazs to use his
first generation technology for medical applications, except for ophthalmic
viscosurgery.

Under Dr. Balazs' leadership, the Company's scientists began to develop
a new class of biopolymers, called hylans. These polysaccharide molecules are
derived by chemical modification of hyaluronan. The Company's hylan products are
highly biocompatible like the naturally occurring hyaluronan, which allows them
to be used in the body without causing allergic or foreign body reactions. The
Company believes that products made of hylans are superior to the products made
of first generation hyaluronan due to the enhanced rheological properties and
the prolonged residence time in tissues.

Using its patented technology, the Company has developed clear
elastoviscous fluids, transparent viscoelastic semi-solid gels, solid particles,
sheaths, tubes and other useful configurations. This broad spectrum of
proprietary products is manufactured through several patented chemical
modifications and cross-linking processes.

The Company's business is to develop, manufacture, market and sell
viscoelastics used as medical therapeutic devices. The use of viscoelastics in
medicine during the past decades has created several new medical therapeutic
modalities including:

- Viscosurgery, the use of elastoviscous fluids to facilitate surgical
procedures in ophthalmology, orthopedics and neurosurgery. The
viscoelastic acts as a surgical tool or implant to protect,
manipulate and separate delicate tissues.

- Viscosupplementation, the use of elastoviscous solutions and
viscoelastic gels in disease conditions to replace tissues and body
fluids.

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- Viscoprotection, the use of elastoviscous fluids and viscoelastic
gels to shield and protect sensitive tissue surfaces, such as those
of the eye, from dryness and noxious environmental conditions.

- Viscoseparation, the use of viscoelastic gels, membranes and fluids
to separate tissues, prevent adhesions, and cover internal and
external wounds to facilitate wound healing and decrease scar
formation.

- Viscoaugmentation, the use of viscoelastic gels for tissue
augmentation to provide a scaffolding for tissue regeneration or an
inert elastic filler in such applications as augmentation of dermal
tissue for the correction of facial wrinkles and depressed scars and
the augmentation of the sphincter muscle in urinary incontinence.

- Viscoregulation, the use of the rheological (physical) properties of
elastoviscous fluids and viscoelastic gels to regulate cell activity,
for example, the targeted delivery of drugs.

Viscoelastic devices are ideally made from the body's own molecules
found in the intercellular matrix, the highly organized structure separating
cells and integrating them into functional tissues. Viscoelastic products are
used in medicine by introducing them into the intercellular matrix during, after
or instead of surgical procedures to supplement, augment, regulate and
manipulate the healing and regenerative processes of the body and to restore the
homeostasis (equilibrium) of the intercellular matrix. Therefore, the use of
viscoelastics for therapeutic purposes, i.e. engineering of the intercellular
matrix, is called matrix engineering.

THERAPEUTICS

The following discussion addresses the Company's medical therapeutic
products, some of which, as noted below, are on the market in certain countries;
certain other products are in late stage development. SEE "BUSINESS-GOVERNMENT
REGULATION."

Synvisc(R)

Synvisc(R), a viscoelastic device made of patented hylan biopolymers,
is used for the treatment of osteoarthritis to reduce pain and improve joint
mobility. Synvisc treatment involves a series of injections into the affected
joint. It supplements the elastoviscosity of the synovial fluid of the arthritic
joint, and is regarded as a liquid prosthesis for the joint because it replaces
the pathologically low elastoviscous fluid with a supplement of fluid with
enhanced elastoviscous properties. This medical treatment modality is called
viscosupplementation. Synvisc is administered over a two-week period and
involves a series of three injections into the arthritic joint.

The Company has completed thirteen clinical studies involving Synvisc
in which approximately 1,726 patients participated. These studies were carried
out and completed in the United States, Germany, the United Kingdom, Sweden and
Canada. The results of these studies indicate that Synvisc is a safe and
efficacious treatment for osteoarthritis of the knee.

The Company received approval to market Synvisc for treatment of
osteoarthritis of the knee joint in Canada in 1993, in Sweden in 1994 and
obtained the CE Mark in late 1995, which permits marketing in the 19 countries
of the European Economic Area ("EEA"). In April 1997, the Company received
approval from the People's Republic of China to register Synvisc, which allows
the Company to import and sell Synvisc as a medical device in every province in
China. In August 1997, the Company received approval from the United States Food
and Drug Administration ("FDA") for the use of Synvisc for treatment of
osteoarthritis of the knee in the United States. Additionally, the Company
received approval in December 1997 to market Synvisc in Israel.

The Company began marketing Synvisc in Canada with its own sales force
in early 1993, and in 1995 signed a distribution agreement with Rhone-Poulenc
Rorer Canada Inc. ("RPR") to share the marketing effort. In September 1995, BMC
and RPR began marketing Synvisc jointly in Canada. In June 1995, Roche AB, a
subsidiary of F. Hoffmann-La Roche Ltd., commenced sales of Synvisc in Sweden
and obtained the distribution rights for Synvisc in South Africa. In December
1996, the Company entered into an agreement with Boehringer Ingelheim France,
S.A. ("Boehringer Ingelheim") for the distribution of Synvisc in France, and in
October 1997 the product

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was officially launched in France. In February 1997, the Company entered into an
agreement with Wyeth-Ayerst Laboratories ("Wyeth"), a division of American Home
Products, for the distribution of Synvisc in the United States, Germany,
Austria, Spain, Portugal, Greece and certain countries in the Middle East and
Central Europe. The Company and Wyeth launched Synvisc in Germany, Austria and
the United States in 1997, and in Spain and Portugal in 1998. In April 1997, the
Company entered into an agreement with Bayer AG ("Bayer") for the distribution
of Synvisc in Australia, Indonesia, Israel, Malaysia, New Zealand, Singapore,
Taiwan and Thailand. In February 1998, the Company entered into an agreement
with Novartis Pharma AG ("Novartis") for the distribution of Synvisc in Latin
America and the Caribbean. The Company has an agreement with Recordati Industria
Chimica e Farmaceutica S.p.A. ("Recordati") for the distribution of Synvisc in
Italy. The Company is currently seeking and negotiating with potential marketing
partners for distribution of Synvisc in certain other European and Asian
countries.

Hylaform(R)

Hylaform(R) is a patented viscoelastic device made of hylan and is used
for viscoaugmentation of dermal tissue to correct facial wrinkles and depressed
scars by injection directly into the dermal tissue. In late 1995, the Company
obtained approval (CE mark) to market this product as a medical device in the 19
countries of the EEA. In June 1996, the Company entered into an agreement with
Collagen Corporation ("Collagen") for the distribution of Hylaform in Europe,
Canada, Japan, Australia and other select countries worldwide. Collagen began
marketing Hylaform in certain European countries in November 1996 and completed
the launch of Hylaform throughout Europe during 1997. Additionally, during 1997
the Company received regulatory approval to market Hylaform in Canada and
Israel. Collagen is expected to start distribution in these countries in the
near future. The Company's Pre-Market Approval ("PMA") application for Hylaform
was submitted to the Food and Drug Administration ("FDA") in 1995 and was
subsequently withdrawn in December 1997. The Company has also entered into a
distribution agreement with Collagen for Hylaform in the United States. Under
such agreement, Collagen has an option for the exclusive distribution rights to
Hylaform in the United States for an additional payment of $7,000,000, upon and
subject to, FDA approval.

Gelvisc(R)Vet

Gelvisc(R)Vet, a viscoelastic device made of hylan biopolymers, was
developed by the Company for the treatment of arthritis in veterinary medicine.
It is used as a viscosupplementation device to treat traumatic arthritis and
osteoarthritis in racehorses. Approval to market this product in Sweden and
France was obtained in 1995 and 1996, respectively. The product is now marketed
by Equinord KB ("Equinord") in Sweden and by Boehringer Ingelheim in France.

Hylashield(R)

Hylashield(R) and Hylashield(R)Nite are sterile, preservative-free,
elastoviscous eye drops that are used to protect, lubricate and moisten the
surface of the eye for patients who experience discomfort or pain associated
with dryness, noxious environmental conditions and other common ocular symptoms
including itching, burning and foreign body sensation. In Canada, Hylashield and
Hylashield Nite have been marketed since June 1993 and October 1995,
respectively, through I-MED Pharma Inc. ("I-MED").

HsS(TM)

HsS(TM) is a sterile, preservative-free, viscoelastic, clear corneal
eye drop that is presented in a single-use container. HsS provides prolonged
moisture control and protection to corneal surfaces during surgery. Use of HsS
reduces the need for frequent applications of saline solution on the corneal
surface, allowing for safer and more efficient surgery. HsS received approval
for marketing in Canada and is anticipated to be launched in 1998.

Hylagel(R)Uro

Hylagel(R)Uro is a proprietary hylan polymer device. It was developed
to act as a long-lasting viscoelastic tissue implant for viscoaugmentation. Its
primary use is to enhance the function of the urinary sphincter muscle by acting
as a filler between weakened muscle tissue and the mucosa in cases of urinary
incontinence. The Company received FDA approval to begin multicenter clinical
trials for HylagelUro.

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THERAPEUTICS IN DEVELOPMENT

The following discussion addresses the Company's medical therapeutic
products that are in development. Preclinical studies have been completed for
these products, and some have been tested in exploratory clinical trials. None
of these products have been submitted to regulatory agencies for marketing
approval anywhere in the world.

Hylagel(R) Vasc

Hylagel(R) Vasc is a proprietary viscoelastic hylan device for
viscoregulation. It was developed to facilitate the delivery of blood
coagulating agents and drugs to targeted sites in arteriovenous malformations
and vascular tumors. The Company has completed exploratory human clinical trials
on this product. The cost of these trials was partially supported by a grant
from the Orphan Products Division of the FDA. The Company is planning to extend
and continue these clinical trials.

Hylasol(TM)

Hylasol(TM) is a proprietary elastoviscous hylan solution designed for
various ophthalmic surgical indications, including contemporary surgical
techniques associated with cataract removal and intraocular lens implantation.
Exploratory clinical trials confirming the safety, efficacy and surgical utility
of these products have been completed. Additional trials are planned.

Hylagel(R)Eye

Hylagel(R)Eye is a proprietary elastoviscous hylan device. It was
developed by the Company as a viscosupplementation product for replacement of
the vitreus in retinal detachment surgery. Based on the results of exploratory
clinical trials, this product is being redesigned to meet newly emerged
therapeutic needs.

Hylagel(R)

Hylagel(R) is a proprietary hylan product engineered as a gel or
membrane device for viscoseparation. It was developed for the prevention of
postsurgical adhesions and for the reduction and control of scar formation after
surgery. It is designed to be used in surgery of the musculoskeletal system, in
neurosurgery, abdominal surgery and gynecological surgery.

Hylasine(TM)

Hylasine(TM) is a viscoelastic proprietary hylan device for use in
viscoseparation of healing mucous membranes following sinus surgery. It is
designed to prevent excessive scar formation and adhesions between mucous
membranes which could cause occlusion (stenosis) of vital air passageways. The
Company has successfully completed preclinical and clinical studies in the
United States. More extensive clinical studies are planned for 1998.

SKIN CARE PRODUCTS

The Company has developed and manufactures nine viscoelastic products,
so-called specialty intermediates for the skin care industry. The Company's skin
care intermediates are proprietary hyaluronan or hylan products, and their
enhanced rheological properties (viscosity, elasticity and pseudoplasticity)
make them superior to low molecular weight hyaluronan products. These highly
elastoviscous formulations of hyaluronan and hylan are unique in their high
water-binding, free radical-scavenging and space-filling properties.

The following specialty intermediates are marketed worldwide by Amerchol
Corp. ("Amerchol"), a subsidiary of Union Carbide Corp.:

Biomatrix(R): a patented, highly elastoviscous complex of hyaluronan,
dermal lipids and proteins. Biomatrix is utilized as a component in several
cosmetic products introduced into the market in the early 1980s by Estee Lauder
in Night Repair and is a component of Advanced Night Repair and certain other
products.

Hyladerm(R): a patented hylan polymer in the form of a highly
elastoviscous solution. Its high molecular weight enables it to be used at
relatively low concentrations in skin care preparations.

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Biocare(R) HA-24: a patented elastoviscous polymer complex formed
between hylan and certain polymers that tightly anchors hylan to skin and hair
in a way that resists wash-off. In this way, the moisturizing and smoothening
benefits of hylan are augmented and made long lasting.

Biocare(R) HA-24-Bio: a patented elastoviscous polymer complex similar
to Biocare HA-24 in all respects, but using hyaluronan of non-animal origin.

Biocare(R) BHA-10: the first product available to the personal care
industry that enhances the utility of a bacteria-derived hyaluronan product by
greatly increasing its rheological properties. Biocare BHA-10 is approximately
ten-fold more elastoviscous and more substantive than the bacterial hyaluronan
from which it is prepared.

Biocare(R) SA: a patented elastoviscous combination of albumin, dextran
sulfate and hylan, Biocare SA is designed to create a light-reflecting layer
that diminishes the appearance of surface imperfections.

Biocare(R) SA-N: a patented elastoviscous combination of albumin,
dextran sulfate and hylan similar to Biocare SA, created to satisfy certain
regulatory requirements in certain countries.

The following products have also been commercialized:

Hylasome(R): a patented viscoelastic, cosmetic grade, water-insoluble
hylan B gel. This product, acting as a molecular sponge, has the ability to
entrap various substances, and can be used as a vehicle for the controlled
release of cosmetic ingredients.

Hylasome(R)LA50: a viscoelastic, cosmetic grade, water-insoluble hylan
B containing patented Hylasome(R). This product is able to deliver lactic acid
to the skin.

DISTRIBUTION AGREEMENTS

The Company has entered into distribution agreements with respect to
certain of the Company's products, as follows:

Wyeth-Ayerst ("Wyeth"). In February 1997, the Company entered into a
distribution agreement with Wyeth, a division of American Home Products. The
agreement provides Wyeth with exclusive marketing rights to Synvisc in the
United States, Germany, Austria, Spain, Portugal, Greece and certain countries
in the Middle East and Central Europe. In 1997, the Company received various
non-refundable payments totaling $17,000,000. The Company is expecting to
receive a milestone payment of $6,000,000 in the fourth quarter of 1998 and
could receive additional payments in the future if sales reach certain levels.
The Company manufactures and supplies Synvisc to Wyeth for a contractual
percentage of Wyeth's sales price. Additionally, Wyeth reimburses the Company,
up to a fixed amount and for a certain period of time, for its costs of
maintaining a team of area business consultants to assist in selling Synvisc in
Europe and the United States. Wyeth launched Synvisc during 1997 in the United
States, Germany and Austria and in early 1998 launched the product in Spain and
Portugal.

Bayer AG ("Bayer"). In April 1997, the Company entered into a
distribution agreement with Bayer. The agreement provides Bayer with exclusive
marketing rights to Synvisc in Australia, Indonesia, Israel, Malaysia, New
Zealand, Singapore, Taiwan and Thailand. In return the Company received an
up-front non-refundable payment of $3,000,000 and could receive a milestone
payment of $2,000,000 upon certain approvals or if sales reach a certain level.
The Company will manufacture and supply Synvisc to Bayer for a contractual
percentage of Bayer's sales price. Additionally, Bayer will reimburse the
Company, up to a fixed amount and for a certain period of time, for its costs of
maintaining several area business consultants to assist in selling Synvisc in
certain countries.

Novartis Pharma AG ("Novartis"). In February 1998, the Company entered
into a distribution agreement with Novartis. The agreement provides Novartis
with the exclusive marketing rights to Synvisc in Latin America and the
Caribbean. In return the Company received an up-front non-refundable payment of
$1,500,000 and will receive an additional $1,600,000 on the earlier of the first
anniversary of commercial launch or December 1999.

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The Company will manufacture and supply Synvisc to Novartis for a contractual
percentage of Novartis' sales price. Additionally, Novartis will reimburse the
Company for its costs of maintaining several area business consultants to assist
in selling Synvisc in certain countries.

F. Hoffmann-La Roche Ltd. ("Roche"). In 1995, pursuant to the amendment
of previous distribution agreements with Syntex, Roche maintained exclusive
marketing rights to Synvisc in Sweden and South Africa. The Company manufactures
and supplies Synvisc to Roche for a contractual percentage of Roche's sales
price. Roche began selling Synvisc in Sweden in June 1995 and is awaiting
marketing approval in South Africa.

Rhone-Poulenc Rorer Canada Inc. ("RPR"). In September 1995, the
Company, through BMC, entered into a distribution agreement with RPR. The
agreement provides RPR with exclusive marketing rights for Synvisc in Canada. In
return, the Company received an up-front non-refundable payment of $3,500,000
and could receive a milestone payment of $2,000,000 if sales reach a certain
level. The Company manufactures and supplies Synvisc to RPR for a contractual
percentage of RPR's sales price. RPR began selling Synvisc in Canada in November
1995.

Collagen Corporation ("Collagen"). In June 1996, the Company entered
into a distribution agreement with Collagen Corporation. The agreement provides
Collagen with exclusive marketing rights for Hylaform in Europe, Canada, Japan,
Australia and other select countries. In return, the Company received an
up-front, non-refundable payment of $5,000,000 and has received and will
continue to receive a royalty based upon sales of Collagen's dermal augmentation
products as well as an additional royalty based on the growth of Collagen's
total dermal augmentation business. Additionally, the Company manufactures and
supplies Hylaform to Collagen for a contractual percentage of Collagen's sales
price. The Company has also entered into a distribution agreement with Collagen
for Hylaform in the United States. Under such agreement, Collagen has an option
for exclusive distribution rights for Hylaform in the United States for an
additional payment of $7,000,000, upon and subject to, FDA approval. Collagen
began selling Hylaform in certain European countries in November 1996 and
successfully completed the launch in all European countries during 1997.

Boehringer Ingelheim France, S.A. ("Boehringer Ingelheim"). In December
1996, the Company entered into a distribution agreement with Boehringer
Ingelheim France, S.A. The agreement provides Boehringer Ingelheim with
exclusive marketing rights for Synvisc in France. In return, the Company
received an up-front non-refundable payment of $1,000,000 and could receive
milestone payments of up to $7,000,000 if sales reach certain levels. The
Company manufactures and supplies Synvisc to Boehringer Ingelheim for a
contractual percentage of Boehringer Ingelheim's sales price. Additionally,
Boehringer Ingelheim reimburses the Company, up to a fixed amount and for a
certain period of time, for its costs of maintaining a team of area business
consultants to assist in selling Synvisc in France. Boehringer Ingelheim began
selling Synvisc in France during 1997.

Recordati Industria Chimica e Farmaceutica S.p.A. ("Recordati"). In
March 1995, the Company entered into a distribution agreement with Recordati.
The agreement provides Recordati with exclusive marketing rights for Synvisc in
Italy. In 1995, Recordati purchased 250,000 shares of the Company's stock. The
Company purchased 43,333 shares of its stock from Recordati in July of 1997.

I-MED Pharma Inc. ("I-MED") In October 1995, the Company entered into a
distribution agreement in Canada with I-MED for three ophthalmic viscoprotection
products. The Company will manufacture and supply the three ophthalmic products
and receive a percentage of I-MED's gross profits.

Farmila Farmaceutici Milano S.r.1. ("Farmila"). In December 1995, the
Company entered into a distribution agreement in Italy with Farmila for two
ophthalmic viscoprotection products. The Company received a non-refundable
up-front payment and will manufacture and supply the two products for an
agreed-upon percentage of Farmila's sales price.

Equinord KB ("Equinord"). The Company has entered into a distribution
agreement with Equinord for the distribution of Gelvisc(R)Vet in the veterinary
market in Sweden, France and Italy. Under the agreement, Equinord will obtain
the necessary regulatory approvals and advertise and promote the product in
these countries. The Company manufactures and supplies the product for a
contractual percentage of Equinord's sales price. Equinord currently sells
Gelvisc itself in Sweden and through Boehringer Ingelheim in France.

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GOVERNMENT LOAN

Societe de Development Industrial du Quebec ("SDI"). In 1993, BMC
obtained a $950,069 construction and manufacturing equipment loan from SDI.
Interest accrues at a variable rate which is currently approximately 7.5%. In
January 1996, the repayment terms of the agreement were amended, whereby the
Company will make quarterly principal payments. The principal payments
correspond to 30% of the Canadian subsidiary's quarterly net profit (excluding
depreciation), with an annual maximum of $167,800 and an annual minimum of
$97,900. The loan agreement contains covenants which require the maintenance of
certain financial ratios by BMC.

MANUFACTURING

At its New Jersey facility, the Company operates a pilot plant for the
manufacture of hylan biopolymers and medical devices made from these polymers.
The Company also has a manufacturing facility at the same location to produce
its skin care intermediates. In 1991, BMC acquired a manufacturing facility in
Canada. BMC began commercial manufacturing of medical devices made from hylan
biopolymers in the second half of 1992. During 1993, the Canadian facility was
inspected by representatives of the Health Protection Branch ("HPB") of the
Canadian Ministry of Health and was certified as meeting good manufacturing
practices ("GMPs") for the manufacturing of small volume injectable products.
Qualification of GMP was accomplished in the facility inspection by the FDA. In
addition, the facility was inspected by the Notified Body of the European Union
in 1997. All of the Company's medical products for sale in the United States,
Canada, Europe and Asia are currently manufactured at the Canadian facility.
During 1997, the Company increased the production capacity of the Canadian
facility in order to support the worldwide demand for Synvisc and Hylaform.

In 1995, the Company received certification (ISO 9001 and EN 46001) of
the quality system for the design and manufacturing of its hylan viscoelastic
devices. These approvals documented that the Company meets the European Union's
("EU") harmonized device standards for both the design and manufacturing
processes of Synvisc and Hylaform. The Company expects the certification to
enhance its ability to design and manufacture any future hylan medical devices
in accordance with currently established procedures and to facilitate approval
of any future viscoelastic products.

In September 1996, the Company entered into a lease for a 93,000 square
foot building in New Jersey. The Company is in the process of modifying this
building to accommodate a new manufacturing plant and space for research and
development laboratories. These new facilities are expected to be completed in
1998.

HUMAN RESOURCES

The Company, including its subsidiaries, currently employs 220
full-time and 3 part-time employees. Of such employees, 18 hold doctoral degrees
(M.D., Ph.D.), 32 hold other advanced degrees and 75 hold bachelor's degrees.
Forty-three of the Company's full-time employees are engaged in research and
development, 100 are engaged in manufacturing, quality control and quality
assurance, and 77 are engaged in sales, marketing, finance and administration.
The Company considers its employee relations to be good.

RESEARCH AND DEVELOPMENT EXPENDITURES

For the years ended December 31, 1997, 1996 and 1995, the Company
expended $5,927,142, $5,484,655 and $5,136,957, respectively, on research and
development relating primarily to personnel expenditures, preclinical and
clinical studies and regulatory expenses in the United States, Europe and
Canada.

SALES BY GEOGRAPHIC AREA AND SIGNIFICANT CUSTOMER DATA

The information required is incorporated herein by reference to the
footnotes to the Company's consolidated financial statements.

7
<PAGE> 10
RISK FACTORS

Certain statements contained in this Annual Report on Form 10-K are
forward-looking within the meaning of Section 27A of the Securities Act of 1933
and involve risk and uncertainty. Such statements should be read in conjunction
with the Company's Securities and Exchange Commission filings and are also
subject to important factors that could cause actual results to differ
materially. Factors that could cause or contribute to such differences include,
but are not limited to, those discussed below, as well as those discussed
elsewhere in this Form 10-K.

Product Liability. The testing, marketing and sale of human health care
products entail an inherent risk of allegations of product liability, and there
can be no assurance that product liability claims will not be asserted against
the Company. Although the Company maintains product liability insurance, there
can be no assurance that the Company has or will be able to maintain sufficient
insurance coverage or will have sufficient resources to satisfy any liability
resulting from these claims.

Patents and Proprietary Technology. In an effort to protect its core
technology, the Company has obtained patent protection in key countries on hylan
technology and certain products and their use. The Company currently has 22
issued or allowed patents in the United States, and 84 issued or allowed patents
and over 41 patents pending in foreign countries relating to its products and
technology. There can be no assurance, however, that the Company's patents will
afford protection against competitors with similar inventions, and there can be
no assurance that the Company's patents will not be infringed upon, designed
around by others or held invalid. The Company also relies on proprietary
know-how and continuing technological development to maintain its competitive
position.

Governmental Regulation. The commercial distribution of the Company's
medical products is subject to regulation by the FDA and foreign regulatory
agencies. The FDA regulates medical products as either medical devices or
drugs/biologicals. Currently, the Company's medical products are regulated as
medical devices by the FDA and by the regulatory agencies of Canada, the
European Union and certain other countries. Some of the Company's products are
under the process of approval by various agencies. The process of obtaining
approvals from such agencies for the Company's products can be costly,
complicated and time-consuming, and there can be no assurance that such
approvals will be granted on a timely basis, if ever. The regulatory process may
delay the marketing of any new products for lengthy periods and could impose
substantial additional costs. In addition, the extent of potentially adverse
governmental regulations which might arise from future legislation,
administrative or judicial action cannot be determined. The Company cannot
predict what effect regulatory actions may have on products already approved for
marketing and on the approval processes to which the Company's products are
subject.

In addition, the FDA inspects manufacturing facilities prior to and
after the approval to market a product. If a material change is made to the
manufacturing process, equipment, or location after receiving approval for
marketing from the FDA, additional regulatory review may be necessary.

The Company's skin care products are not subject to pre-market approval
requirements or FDA mandated performance standards. However, they are subject to
provisions of law prohibiting the commercial marketing of misbranded or
adulterated products.

Competition. The Company believes that its primary competitive advantage
is derived from its superior technology and its long standing know-how in the
area of viscoelastics. Competition for Synvisc currently exists primarily from
products based on earlier technology. In the United States, the FDA has approved
Hyalgan(R) which is produced by Fidia and is marketed in the United States by
Orthologic. Another product based on earlier technology is Orthovisc(R), a
product which has not received marketing approval from the FDA, but is marketed
in Canada and in certain other countries. Orthovisc is produced by Anika
Therapeutics. Anika has entered into a marketing agreement with Zimmer to
distribute the product in the United States. In Europe, competition is primarily
comprised of Hyalgan and Artz(R), a Japanese product. To the best knowledge of
the Company, there are no other viscosupplementation products on the market, or
in development, which, like Synvisc, have the physical properties of viscosity,
elasticity or molecular weight which match the physical properties of healthy,
young synovial fluid. Competition will also depend on product acceptance by
doctors and other customers, the ability to interact directly with customers in
developing new medical procedures and applications, advances in the commercial
applicability of

8
<PAGE> 11
hylan-based technology and greater availability of capital for investment in
these fields. Product cost and third party reimbursement policies will also be
important factors. The Company believes its patent position with respect to
chemically modified, cross-linked hyaluronan polymers (hylans) makes it more
difficult for others to commercialize chemically modified hyaluronan materials.
However, chemically modified hyaluronan materials are known to be under
development by a number of potential competitors. Other substances or
technologies may be, now or in the future, the basis of competitive products
that could render the Company's technology obsolete or non-competitive.

Reimbursement. Sales of the Company's products may be affected by the
availability of reimbursement from third-party payors, such as governmental
health administration authorities, private health insurers and other
organizations. Limitations on such reimbursement may have a material adverse
impact on the Company's business, results of operations and financial condition.
The Company has received favorable preliminary indications in the United States
from the Health Care Finance Administration ("HCFA") and several private health
insurance organizations with respect to reimbursement for Synvisc. Synvisc is
currently reimbursed by over one-half of the Medicare regional insurance
carriers. Synvisc is also on the list of government reimbursable products in
Sweden. Currently, Synvisc has not been approved for reimbursement by the
Canadian provincial governments; however, several Canadian private insurance
companies do provide reimbursement for Synvisc therapy. In addition, discussions
with European government agencies regarding Synvisc reimbursement are currently
underway. Hylaform is not expected to be reimbursed by third-party payors.

Dependence on Distribution Relationships. The Company has entered into
several distribution agreements for the marketing and distribution of some of
its products. There can be no assurance that the Company will be successful in
maintaining its current arrangements or that the Company's marketing partners
will devote adequate resources to accomplish such marketing and distribution or
be successful in such efforts.

Dependence Upon Key Personnel. The future success of the Company is highly
dependent on the members of its management and scientific staff. The loss of one
or more key employees could have a material adverse effect on the Company.

Rapid Growth. The Company has undertaken an aggressive growth strategy
that includes expenditures for personnel and manufacturing facilities that will
be required to support an increased demand for the Company's products. The
strategy includes certain risks, some of which are a higher level of operating
expenses, difficulty associated with attracting and managing new employees, and
the difficulties associated with managing a fast growing organization.

Fluctuation in Operating Results. The Company's operating results may
fluctuate from period to period for several reasons. The Company has attempted
to plan its operating expenses on the basis that revenues from product sales
will continue to grow. As a result, a shortfall in product sales may cause
results for a given period to be below Company expectations. Such shortfall
could result from a number of factors, including but not limited to, lower than
expected demand, changes in distribution partner purchasing patterns, changes in
reimbursement, manufacturing interruptions, overall economic conditions and
natural disasters.

Stock Price Volatility. The Company's stock price is subject to
significant volatility. The stock price may be affected by clinical trial
results and other product development related announcements by Biomatrix or its
competitors, regulatory matters, announcements in the scientific community,
legal matters, changes in reimbursement policies, or industry and market trends
unrelated to the Company's performance. Also, if earnings in any given quarter
fail to meet the expectations of the investment community, there could be an
adverse impact on the Company's stock price.

Manufacturing. The Company is subject to significant manufacturing risks.
Currently all of the Company's medical products are produced and supplied from
the Company's Canadian facility. The Company is in the process of building a
manufacturing facility in New Jersey. This facility is not expected to be
on-line until late 1998 or early 1999. The Canadian manufacturing facility may
not have sufficient capacity to meet the current and expected demand from all of
the countries for which the Company has signed distribution agreements. It is
not expected that the Company will be able to meet the demands from all of these
countries until the facility in New Jersey is on-line, and thus distributors in
major markets may experience back orders during this period.

9
<PAGE> 12
The manufacturing process utilized by the Company is highly complex and is
subject to significant government regulation. There can be no assurance that the
Company will not experience manufacturing problems in the startup and expansion
of its facilities that could result in delays in production, delivery delays or
yield fluctuations. In addition, the Company will be required to add new
production equipment and successfully hire, train and manage additional
personnel. In the event the Company's expansion plans are not implemented on a
timely basis for any reason, the Company could become subject to additional
capacity constraints. The Company's business, results of operations and
financial condition could be materially and adversely affected if it were to
experience any significant disruption in the operation of its facilities

ITEM 2. PROPERTIES

The Company's executive, administrative, research and development and
production facilities are located in Ridgefield, New Jersey in leased premises
of approximately 57,000 square feet. In September 1996, the Company entered into
a lease for a building of approximately 93,000 square feet in Ridgefield, New
Jersey. The Company is in the process of building a manufacturing plant and
laboratories for its research and development activities. BMC owns a 28,000
square foot manufacturing facility in Pointe-Claire, Quebec, Canada.

ITEM 3. LEGAL PROCEEDINGS

In August 1990, the Company received a notice from the Pennsylvania
Department of Environmental Resources ("DER") that it is one of approximately
1,000 potentially responsible parties ("PRPs") that may have clean-up
responsibility at the Industrial Solvents and Chemical Company site in York
Haven, Pennsylvania (the "Site"). During the late 1980s, the Company, through a
licensed waste disposal transport company, shipped industrial solvents to the
Site, which was operating as a recycling facility. The DER reviewed hazardous
waste found at the Site as well as the DER's own records in order to identify
additional PRPs and to quantify each PRP's volumetric contributions. The Company
is a member of a steering committee that consists of many PRPs. Although neither
the total clean-up cost nor the portion of the total clean-up cost assigned to
each PRP has been determined, the Company estimated, based upon the advice of a
consultant, that its liability would be approximately $780,000. Further, the
same consultant has reported to the Company that there is less than a 10% chance
that its liability might exceed $1,070,033. During the second quarter of 1995
the Company paid its first assessment for clean-up costs of $79,390.
Additionally, the Company paid $15,000 during the first quarter of 1997;
therefore, the reserve at December 31, 1997 was $685,610. The steering committee
for the PRPs has prepared a buy-out proposal pursuant to a consent order with
the DER. This buy-out proposal identifies each PRP's assigned portion of assumed
total clean-up costs. The Company's assigned portion of assumed clean-up costs
within the proposal is currently less than its reserve, however there can be no
assurance that the proposal will be accepted. When the final remedy is selected
by the DER, the Company plans to settle out of the matter pursuant to the buyout
proposal. The Company will monitor this situation and make any necessary
adjustments to the reserve once additional information is available.

In October 1996, Michael Jarcho ("Jarcho") filed suit in the United
States District Court for the Southern District of California seeking to recover
damages and declaratory judgment for the alleged breach by the Company of
Jarcho's consulting agreement. A consulting agreement had been entered into
between the Company and Jarcho on December 2, 1988. The agreement contains
certain royalty provisions for products that result from Jarcho's consultancy.
Jarcho contends, inaccurately in the Company's view, that Hylaform resulted from
his consultancy. Jarcho seeks compensatory damages of $300,000 plus a royalty on
the Company's net sales of Hylaform as well as punitive damages and recovery of
attorney fees. The Company believes that no royalties are owed Jarcho as a
result of Hylaform sales. Jarcho's case was dismissed on January 10, 1997, on
the grounds that the agreement requires such disputes to be brought exclusively
in New Jersey state court. Jarcho moved for a partial reconsideration of the
decision, the Company opposed that request, and the request was denied. On June
16, 1997 Jarcho filed suit in New Jersey state court. The Company intends to
defend this matter vigorously. The Company has not made any provision in the
accompanying consolidated financial statements for any liability that might
result.

10
<PAGE> 13
ITEM 4. SUBMISSION OF MATTERS TO A VOTE OF SECURITY HOLDERS

No matters were submitted to a vote of the Company's shareholders
during the last quarter of its fiscal year ended December 31, 1997.

EXECUTIVE OFFICERS

Information with respect to the Executive Officers of the Company
furnished by them is set forth below:

<TABLE>
<CAPTION>
Name Age Position(s) with the Company
---- --- ----------------------------
<S> <C> <C>
Endre A. Balazs, M.D. .........................78 Chief Executive Officer and Chief Scientific Officer; Director
Rory B. Riggs....................................44 President; Director
Janet L. Denlinger, Ph.D. .......................52 Executive Vice President; Director
Wesley M. Domareki...............................48 President, ORLO Division
Beatrice Morales.................................48 Vice President, Quality Assurance and Quality Control
Richard S. Romasz................................48 Vice President, Clinical Affairs
Maxine Seifert...................................44 Vice President, Finance and Chief Financial Officer
Donald E. Woodhouse..............................51 Vice President, Manufacturing
</TABLE>

ENDRE A. BALAZS, M.D., CHIEF EXECUTIVE OFFICER, CHIEF SCIENTIFIC
OFFICER AND DIRECTOR. Dr. Balazs, a co-founder of the Company, became Chief
Executive Officer and Chief Scientific Officer of the Company in February 1987,
having served as President from inception of the Company until that time. He has
also served as a director from the inception of the Company to the present. He
is the Malcolm P. Aldrich Research Professor Emeritus at the College of
Physicians and Surgeons, Columbia University. Prior to joining Columbia in 1975,
he taught at Harvard Medical School for 25 years, during which time he was also
co-founder, research director and president of The Retina Foundation and the
Boston Biomedical Research Institute. From 1968 to 1978, Dr. Balazs was
president and owner of Biotrics, Inc., which developed and manufactured the
first hyaluronan therapeutic products used in medicine. He is the author of more
than 300 scientific articles and patents. Dr. Balazs received an M.D. degree
from the University of Budapest, Hungary. He is married to Dr. Denlinger.

RORY B. RIGGS, PRESIDENT AND DIRECTOR. Mr. Riggs was elected President
on April 1, 1996 and Acting Chief Financial Officer in September 1996, serving
in that capacity until January 1998. He has served as a Director of the Company
since October 1990. Since 1990, he has been affiliated with ITIM Corp., an
investment advisory and venture capital firm specializing in pharmaceutical and
biotechnology investments. From 1991 to 1994, he was acting President and Chief
Executive Officer of RF&P Corporation, a company wholly-owned by the Virginia
Retirement System. Until 1990, Mr. Riggs was a Managing Director in the Mergers
and Acquisitions Department at Paine Webber Incorporated, where he was employed
for more than nine years. He is a graduate of Middlebury College and Columbia
University's Graduate School of Business.

JANET L. DENLINGER, Ph.D., EXECUTIVE VICE PRESIDENT AND DIRECTOR. Dr.
Denlinger, a co-founder of the Company, has been an Executive Vice President of
the Company since 1989 and a Vice President and Director of the Company since
its inception. She was a research associate of Dr. Balazs for 20 years at the
Boston Biomedical Research Institute and then at the Department of
Ophthalmology, College of Physicians and Surgeons, Columbia University. She is
the author of numerous publications in physiology, biochemistry and biological
activity and metabolism of hyaluronan. Dr. Denlinger received a Ph.D. degree in
biochemistry from the University of Lille, France. She is married to Dr. Balazs.

WESLEY M. DOMAREKI, PRESIDENT, ORLO DIVISION. Mr. Domareki joined the
Company in January 1991 as Vice President, International Marketing and Business
Development. In 1994, he was appointed President of the Company's
Otorhinolaryngology and Ophthalmology Division. Prior to joining the Company,
Mr. Domareki was employed by Pharmacia Inc. for 17 years. By 1989, as Vice
President, International Marketing and Business Development for Pharmacia
Ophthalmics, he had been involved in the successful commercialization and
marketing of Healon(R) in the United States, Japan, Australia and various
European countries. Mr. Domareki received a B.S.

11
<PAGE> 14
degree in business administration from Villanova University and holds an M.B.A.
degree in pharmaceutical marketing and economics from Fairleigh Dickinson
University.

BEATRICE MORALES, VICE PRESIDENT, QUALITY ASSURANCE AND QUALITY CONTROL.
Ms. Morales joined the Company in 1981, as Assistant Scientist and became
Director of Quality Control and Quality Assurance in 1986. In 1991, she was
promoted to her present position. Prior to joining the Company, Ms. Morales
served on Dr. Balazs' research staff at the Department of Ophthalmology of
Columbia University. Ms. Morales received a B.S. degree in Biology from the City
College of New York.

RICHARD S. ROMASZ, Ph.D., VICE PRESIDENT, CLINICAL AFFAIRS. Dr. Romasz
joined the Company in November 1995 as Vice President, Clinical Affairs. Prior
to joining the Company, Dr. Romasz was employed for over 19 years with Pharmacia
Inc. in its Clinical Research Department. His last position was as Vice
President-Clinical Research, Pharmacia Inc., Ophthalmics. Dr. Romasz was
intensely involved with the clinical trials and regulatory proceedings related
to Healon(R) and Hylartin V(R) in the United States, the first hyaluronan
products ever marketed worldwide and developed by Dr. Balazs and licensed to
Pharmacia in 1972. Dr. Romasz received a Ph.D. in nutrition from Rutgers
University.

MAXINE SEIFERT, VICE PRESIDENT, FINANCE AND CHIEF FINANCIAL OFFICER. Ms.
Seifert joined the Company in January 1998. Prior to joining the Company, Ms.
Seifert was employed for over thirteen years with Colgate-Palmolive Company in a
variety of senior financial positions, most recently as Vice President,
Financial Business Development. Prior experiences include positions with
Deloitte & Touche, a public accounting firm. Ms. Seifert received a B.S.B.A. in
Accounting from Georgetown University and holds an MBA from the Harvard
University Graduate School of Business Administration.

DONALD E. WOODHOUSE, VICE PRESIDENT, MANUFACTURING. Mr. Woodhouse joined
the Company in May 1991. Prior to joining the Company, Mr. Woodhouse was
employed for seven years with Sterling Drug, Inc. in a variety of manufacturing
and engineering positions, most recently as Director of Pharmaceutical
Engineering. Prior experience includes positions with Bausch & Lomb, American
Hospital Supply (Critical Care Division) and Merck, Sharp & Dohme in
manufacturing, engineering and general management over a 15-year period. Mr.
Woodhouse received a B.S. degree in biology from Hampden-Sydney College and has
completed graduate business courses at Temple University.

PART II

ITEM 5. MARKET FOR REGISTRANT'S COMMON EQUITY AND RELATED SHAREHOLDER MATTERS

MARKET INFORMATION

The Company's common stock trades on the Nasdaq National Market under
the symbol "BIOX." The following table sets forth the range of high and low last
sale prices per share for the Company's common stock on the Nasdaq National
Market for 1997 and 1996.

<TABLE>
<CAPTION>
Year Ended December 31, 1997
----------------------------
High Low
---- ---
<S> <C> <C>
First Quarter ......................... $17.50 $13.38
Second Quarter ........................ 21.13 11.25
Third Quarter ......................... 41.00 19.38
Fourth Quarter ........................ 38.13 26.50
</TABLE>

<TABLE>
<CAPTION>
Year Ended December 31, 1996
----------------------------
High Low
---- ---
<S> <C> <C>
First Quarter ......................... $19.50 $11.13
Second Quarter ........................ 17.50 12.25
Third Quarter ......................... 16.75 11.25
Fourth Quarter ........................ 16.75 13.25
</TABLE>

12
<PAGE> 15
HOLDERS

As of March 2, 1998, there were approximately 241 shareholders of
record. This does not reflect beneficial shareholders who hold their stock in
nominee or "street" name through various brokerage firms.

DIVIDENDS

No cash dividends have been paid on the Common Stock to date, and the
Company does not anticipate any cash dividends in the foreseeable future.

ITEM 6. SELECTED FINANCIAL DATA

The following is a summary of selected historical financial data for
the Company. The data for each of the three years in the period ended December
31, 1997, have been derived from, and all data should be read in conjunction
with the audited consolidated financial statements of the Company, included in
Item 8 of this Report.

<TABLE>
<CAPTION>
YEARS ENDED DECEMBER 31,
--------------------------------------------------------------------------
1997 1996 1995 1994 1993
---- ---- ---- ---- ----
<S> <C> <C> <C> <C> <C>
CONSOLIDATED OPERATING DATA:
Total Revenues ............................ $ 32,564,256 $ 15,578,912 $ 11,070,865 $ 8,906,075 $ 3,505,613
Cost and Expenses:
Cost of Goods Sold ...................... 3,609,907 2,563,060 1,911,426 1,597,369 1,729,214
Research and Development ................ 5,927,142 5,484,655 5,136,957 5,059,660 5,504,594
Selling, General and Administrative ..... 7,806,392 5,320,162 4,942,946 7,106,517 5,267,472
Provision for Environmental
Expense .............................. -- -- -- -- 363,000
------------ ------------ ------------ ------------ ------------
Total Cost and Expenses ................... 17,343,441 13,367,877 11,991,329 13,763,546 12,864,280
------------ ------------ ------------ ------------ ------------
Income (Loss) from Operations ............. 15,220,815 2,211,035 (920,464) (4,857,471) (9,358,667)
Interest and Miscellaneous Income ......... 1,052,899 694,102 701,183 340,526 462,204
(Provision for) Benefit from Income Taxes . (536,000) (135,000) -- 137,638 --
------------ ------------ ------------ ------------ ------------
Net Income (Loss) ......................... $ 15,737,714 $ 2,770,137 ($ 219,281) ($4,379,307) ($8,896,463)
============ ============ ============ ============ ============

Net Income (Loss) per Share - Basic ....... $ 1.44 $ 0.27 ($ 0.02) ($ 0.47) ($ 0.99)
Net Income (Loss) per Share - Diluted ..... $ 1.39 $ 0.25 ($ 0.02) ($ 0.47) ($ 0.99)

Shares used in computing Net Income (Loss):
Basic ................................... 10,894,769 10,434,230 9,876,587 9,256,165 8,970,195
============ ============ ============ ============ ============
Diluted ................................. 11,327,206 10,895,026 9,876,587 9,256,165 8,970,195
============ ============ ============ ============ ============
</TABLE>

<TABLE>
<CAPTION>
YEARS ENDED DECEMBER 31,
--------------------------------------------------------------------------
1997 1996 1995 1994 1993
---- ---- ---- ---- ----
<S> <C> <C> <C> <C> <C>
CONSOLIDATED BALANCE SHEET DATA:
Working Capital ................. $21,902,140 $13,834,393 $10,078,132 $ 7,792,087 $ 8,879,724
Total Assets .................... 44,224,647 25,994,027 17,381,576 15,554,641 16,907,890
Long-Term Debt and Capital Lease
Obligations (Excluding Current
Maturities) ................. 5,599,193 5,798,522 728,525 1,515,465 1,399,359
Total Shareholders' Equity ..... 34,608,518 17,703,935 14,115,809 10,184,469 10,986,666
</TABLE>

13
<PAGE> 16
ITEM 7. MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS
OF OPERATIONS

OVERVIEW

The Company has been principally engaged in the research and
development, manufacturing and commercialization of proprietary viscoelastic
biological polymers, called hylans, for use in therapeutic medical applications
and skin care. During the past four years, a significant source of revenue for
the Company has been from certain up-front payments relating to corporate
license and distribution agreements. The Company expects milestone payments
from existing agreements to continue to be an important source of revenues.

The Company's business is subject to significant risks. Forward-looking
comments included herein are subject to and should be read in conjunction with
the "Risk Factors" section of this Form 10-K. As a significant amount of the
Company's future revenues may be based on payments from corporate license and
distribution agreements, the Company's total revenues and net income will
fluctuate from quarter to quarter. Some of these fluctuations may be significant
and, as a result, quarter to quarter comparisons may not be meaningful. As of
December 31, 1997, the Company's accumulated deficit was $19,826,634, a
reduction of $15,737,714 from the Company's accumulated deficit of $35,564,348
as of December 31, 1996.

RESULTS OF OPERATIONS FOR THE YEARS ENDED DECEMBER 31, 1997 AND 1996

REVENUES. Total revenues for the year ended December 31, 1997 were
$32,564,256, representing an increase of $16,985,344 or 109% from the same
period of 1996. Net product sales for the year ended December 31, 1997 were
$11,734,908 representing an increase of $6,784,256 or 137% over the same period
in 1996. The increase in product sales was due primarily to the launch of
Synvisc in the United States and in certain European countries and higher sales
of Hylaform in certain European countries. Income from licenses, royalties,
research contracts and grants were $20,829,348 in 1997, an increase of
$10,201,088 or 96.0% from 1996, and represented 64.0% of 1997 total revenues.
This increase was due primarily to the receipt of up-front non-refundable fees
of $8,250,000 related to the licensing of Synvisc for distribution in the
United States and certain foreign countries and a $12,000,000 milestone payment
from Wyeth which was received when the United States FDA approved Synvisc for
marketing in August 1997. Included in license fees for the year ended December
31, 1997, were non-refundable up-front and milestone payments from Wyeth and
Bayer of $17,000,000 and $3,000,000, respectively. Included in license fees for
the year ended December 31, 1996, were up-front non-refundable payments from
Collagen Corporation and Boehringer Ingelheim of $5,000,000 and $1,000,000,
respectively.

COSTS AND EXPENSES. Total costs and expenses were $17,343,441 for the
year ended December 31, 1997, representing an increase of $3,975,564 or 29.7%
over the same period of 1996. Cost of goods sold for the years ended December
31, 1997 and 1996 were $3,609,907 and $2,563,060, respectively, which
represented 30.8% and 51.8% of net product sales, respectively. Research and
development expenses were $5,927,142 for the year ended December 31, 1997,
representing an increase of $442,487 or 8.1% over the prior year, due primarily
to higher personnel costs. Selling, general and administrative expenses for the
year ended December 31, 1997 were $7,806,392, representing an increase of
$2,486,230 or 46.7% over the prior year. The increase in selling general and
administrative expenses was due primarily to increased personnel and legal costs
associated with establishing the infrastructure required to manufacture and
market the Company's products globally.

INTEREST AND MISCELLANEOUS INCOME. Interest expense was $105,696 for
the year ended December 31, 1997, which represented a decrease of $11,769 over
the prior year. Interest and miscellaneous income for the year ended December
31, 1997 was $1,158,595, representing an increase of $347,028 over the prior
year, due to higher average cash and investment balances.

RESULTS OF OPERATIONS FOR THE YEARS ENDED DECEMBER 31, 1996 AND 1995

REVENUES. Total revenues for the year ended December 31, 1996 were
$15,578,912, representing an increase of $4,508,047 or 40.7% from the same
period of 1995. Net product sales for the year ended December 31, 1996 were
$4,950,652, representing an increase of $1,336,883 or 37.0% over the same period
in 1995. This increase was

14
<PAGE> 17
due primarily to higher sales of Synvisc in Canada and Sweden and from new sales
of Hylaform in certain European countries. Additionally, skin care product sales
increased $243,831 or 13.9% primarily resulting from the timing of orders. Sales
of skin care products to the Company's distributor, Amerchol, represented 99.4%
of total skin care sales. Income from licenses, royalties, research contracts
and grants were $10,628,260 in 1996, an increase of $3,171,164 or 42.5% from
1995 and represented 68.2% of 1996 total revenues. This increase was due
primarily to the receipt of non-refundable fees, which amounted to $9,375,000
for the year ended December 31, 1996, representing an increase of $2,548,412
over the same period of 1995. Included in license fees for the year ended
December 31, 1996, were up-front payments from Collagen Corporation and
Boehringer Ingelheim of $5,000,000 and $1,000,000, respectively. Included in
license fees for the year ended December 31, 1995 was an up-front payment from
RPR of $3,500,000.

COSTS AND EXPENSES. Total costs and expenses were $13,367,877 for the
year ended December 31, 1996, representing an increase of $1,376,548 or 11.5%
over the same period of 1995. Cost of goods sold for the years ended December
31, 1996 and 1995 were $2,563,060 and $1,911,426, respectively, which
represented 51.8% and 52.9% of sales for the years ended December 31, 1996 and
1995, respectively. Research and development expenses were $5,484,655 for the
year ended December 31, 1996, representing an increase of $347,698 or 6.8% over
the prior year, due primarily to higher consulting costs. Selling, general and
administrative expenses for the year ended December 31, 1996 were $5,320,162,
representing an increase of $377,216 or 7.6% over the prior year, due primarily
to higher legal costs associated with patents and trademarks.

INTEREST AND MISCELLANEOUS INCOME. Interest expense was $117,465 for
the year ended December 31, 1996, which represented an increase of $10,394 over
the prior year. Interest and miscellaneous income for the year ended December
31, 1996 was $811,567, representing an increase of $3,313 over the prior year,
due to higher average cash and investment balances. Additionally, the increase
in interest income was offset by a nonrecurring payment of $200,000 included in
miscellaneous income during 1995 relating to a reimbursement for promotional
materials.

INCOME TAXES

Provisions for federal or state income taxes were not necessary for the
year ended December 31, 1995. In 1997 and 1996, the Company recorded federal and
state tax provisions totaling $536,000 and $135,000, respectively, primarily for
federal alternative minimum and state taxes. The Company has provided a full
valuation allowance on the deferred tax assets due to the uncertainty of
realization.

LIQUIDITY AND CAPITAL RESOURCES

The Company had cash and cash equivalents of $17,387,085 at December
31, 1997. The Company invests its excess cash in U.S. government securities and,
accordingly, any security purchased with a maturity of less than three months is
classified as cash and cash equivalents. As of December 31, 1997 all of the
Company's cash and cash equivalents were held in operating and money market
accounts.

The Company's operations over the past three years have been financed
primarily from non-refundable up-front and milestone license fee payments from
corporate partners, the utilization of the Company's cash and investments, and
the private placement of equity securities. Over the past three years, the
Company has received funding of $5,720,900 from the private placement of equity
securities and $35,480,000 from non-refundable license fee payments.

For the year ended December 31, 1997 the Company had positive cash flow
from operations of $11,297,045 which was primarily due to non-recurring fees
received during the year of $20,250,000 offset by cash outflows related to
increased working capital levels needed to support Synvisc launches. In 1997 the
Company invested $9,140,447 in property, plant and equipment, primarily
associated with building manufacturing capacity in the U.S. and an increase in
capacity of the Canadian manufacturing facility. The Company continues to lease
a 93,000 square foot building in New Jersey in which the manufacturing capacity
will reside. The Company has an option to acquire this building at a price of
approximately $4,500,000. Should the Company not exercise its option

15
<PAGE> 18
in 1999, the landlord has the right to require the Company to purchase this
building for approximately the same price. The Company also plans to relocate
its executive and administrative offices and research and development
laboratories to this building upon the expiration in 1999 of the Company's lease
on its current headquarters in New Jersey. Additionally, the Company received
$768,263 in 1997 from the exercise of Company stock options and $1,890,000 from
the sale of common stock to certain officers of the Company. The Company
utilized $928,951 in funds to repurchase 43,333 shares of common stock from one
of its distribution partners.

In 1997, approximately $6,823,000 of the $9,140,447 invested in
property, plant and equipment was spent on manufacturing capacity in the United
States. During 1998, the Company expects to invest an additional $10,500,000 to
increase capacity at its United States location. In addition, the Company
intends to build new laboratories and administrative offices to house its world
headquarters as part of the same project at an estimated cost of $12,000,000 and
$6,000,000, respectively. The Company expects to complete the laboratories and
administrative offices by the summer of 1999. The Company plans to seek lease
and mortgage financing which, if obtained, could fund a portion of these capital
costs.

During 1998, the Company also expects to utilize cash for the start-up
of its manufacturing capacity in the U.S., including, but not limited to, funds
for payroll and benefits, training and development, materials and supplies, and
working capital requirements. The Company also expects to incur higher expenses
in 1998 associated with developing its internal infrastructure to support the
administration of its various distribution agreements and expanded global
operations. The Company believes that its capital needs, start-up costs, and
higher operating expenses will be supported by its operations, existing cash
position, up-front license fee payments from the potential completion of
additional distribution agreements, milestone payments from existing corporate
partners and potential financing arrangements.

In June 1997, the FASB issued Statement of Financial Accounting
Standards No. 130 "Reporting Comprehensive Income" which establishes standards
for reporting and display of comprehensive income and its components in a full
set of financial statements. The Company is required to adopt this standard in
1998 and believes the principal additional component of comprehensive income
that will be required to be disclosed is foreign currency translation.

In June 1997, the FASB issued Statement of Financial Accounting
Standards No. 131 "Disclosures about Segment of an Enterprise and Related
Information" which establishes standards for the way that public enterprises
report information about operating segments, geographic areas, products and
major customers. The Company is required to adopt this standard in 1998 and is
currently evaluating the impact of this standard.

CONTINGENT LIABILITY

16
<PAGE> 19
by the DER, the Company plans to settle out of the matter pursuant to the buyout
proposal. The Company will monitor this situation and make any necessary
adjustments to the reserve once additional information is available.

YEAR 2000

The Year 2000 issue is the result of computer programs being written
using two digits rather than four to define the applicable year. Some computer
programs that have time-sensitive software may recognize a date using "00" as
the year 1900 rather than the year 2000. This could result in a system failure
or miscalculations causing disruptions of operations, including a temporary
inability to process transactions, send invoices, or engage in normal business
and operating activities. The Company believes that its financial and
operational systems, with limited modifications, will function properly with
respect to dates in the year 2000 and thereafter. The Company estimates that the
costs associated with the Year 2000 issue will be insignificant, and as such
will not have a material impact on the Company's financial position or operating
results. There can be no assurance that the Company's marketing partners and
suppliers will not have Year 2000 issues.

ITEM 8. FINANCIAL STATEMENTS AND SUPPLEMENTARY DATA

See page F-1 of this Report, which includes an index to the
consolidated financial statements.

ITEM 9. CHANGES IN AND DISAGREEMENTS WITH ACCOUNTANTS AND FINANCIAL DISCLOSURE

Not applicable

PART III

ITEM 10. DIRECTORS AND EXECUTIVE OFFICERS OF THE REGISTRANT

(a) Directors. The information with respect to directors required by
this item is incorporated herein by reference to the Company's Proxy Statement
relating to the Company's Annual Meeting of Shareholders to be held on May 29,
1998 (the "Proxy Statement").

(b) Executive Officers. The information with respect to executive
officers required by this item is set forth in Part I of the Report.

(c) Reports of Beneficial Ownership. The information with respect to
reports of beneficial ownership required by this item is incorporated herein by
reference to the Company's Proxy Statement.

ITEM 11. EXECUTIVE COMPENSATION

Information required under this Item is incorporated herein by
reference to the Company's Proxy Statement.

ITEM 12. SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT

Information required under this Item is incorporated herein by
reference to the Company's Proxy Statement.

ITEM 13. CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS

Information required under this Item is incorporated herein by
reference to the Company's Proxy Statement.

17
<PAGE> 20
PART IV

ITEM 14. EXHIBITS, FINANCIAL STATEMENT SCHEDULES AND REPORTS ON FORM 8-K

LIST OF FINANCIAL STATEMENTS

See page F-1 of this Report, which includes an index to consolidated
financial statements.

LIST OF FINANCIAL STATEMENT SCHEDULES

None.

LIST OF EXHIBITS (numbered in accordance with Item 601 of Regulations S-K)

3.1 Amended and Restated Certificate of Incorporation of Biomatrix,
Inc. as filed as an Exhibit to Registration No. 33-41424, and
incorporated herein by reference thereto.

3.2 Amended and Restated Bylaws of the Company as filed as an Exhibit
to Registration No. 33-41424, and incorporated herein by reference
thereto.

4 Specimen Stock Certificate as filed as an Exhibit to Registration
No. 33-41424, and incorporated herein by reference thereto.

10.1 Stock Purchase Agreement dated June 21, 1991 by and among
Biomatrix, Inc., Biomatrix Medical Canada Inc. and Investment Fund
in Biotechnology BioCapital Limited Partnership, as filed as an
Exhibit to Registration No. 33-41424, and incorporated herein by
reference thereto.

10.2 Shareholders Agreement dated June 21, 1991 between Biomatrix,
Inc., Biomatrix Medical Canada Inc. and Investment Fund in
Biotechnology BioCapital Limited Partnership, as filed as an
Exhibit to Registration No. 33-41424, and incorporated herein by
reference thereto.

10.3 Technology License Agreement dated as of June 21, 1991 between
Biomatrix, Inc. and Biomatrix Medical Canada Inc. as filed as an
Exhibit to Registration No. 33-41424, and incorporated herein by
reference thereto.

10.4 Management Services Agreement dated as of June 21, 1991 between
Biomatrix, Inc. and Biomatrix Medical Canada Inc. as filed as an
Exhibit to Registration No. 33-41424, and incorporated herein by
reference thereto.

10.5 Employment Agreement dated December 30, 1988 between Biomatrix,
Inc. and Endre A. Balazs, M.D. as filed as an Exhibit to
Registration No. 33-41424, and incorporated herein by reference
thereto. Management contract or compensatory plan required to be
filed as an exhibit to this form pursuant to Item 14(c) of this
report.

10.6 Development Agreement by and among Biomatrix, Inc., Biomatrix
Svenska AB and OA Investor KB (Up-Will) dated February, 1990 as
filed as an Exhibit to Registration No. 33-41424, and incorporated
herein by reference thereto.

10.7 1984 Stock Option Plan (as amended), and forms of Incentive and
Non-Statutory Stock Option Agreements as filed as an Exhibit to
Registration No. 33-41424, and incorporated herein by reference
thereto. Management contract or compensatory plan required to be
filed as an exhibit to this form pursuant to Item 14(c) of this
report.

18
<PAGE> 21
10.8 Forms of Employment and Confidentiality Agreements, as filed as an
Exhibit to Registration No. 33-41424, and incorporated herein by
reference thereto.

10.9 Lease dated June 1, 1992 between Biomatrix, Inc. and Safer
Development & Management Corp. for lease of premises located at 65
Railroad Avenue, Ridgefield, New Jersey, as filed as an Exhibit to
the 1992 annual report on Form 10-K, and incorporated herein by
reference thereto.

10.10 License Agreements dated as of May 21, 1982 by and between
Biomatrix, Inc. and each of Drs. Endre A. Balazs, Janet L.
Denlinger and Gerald S. Lazarus, as filed as an Exhibit to
Registration No. 33-41424, and incorporated herein by reference
thereto.

10.11 Amendment to Employment Agreement dated December 30, 1988 between
Biomatrix, Inc. and Endre A. Balazs, M.D., as filed as an Exhibit
to the 1992 annual report on Form 10-K, and incorporated herein by
reference thereto. Management contract or compensatory plan
required to be filed as an exhibit to this form pursuant to Item
14(c) of this report.

10.12 Retirement Plan Agreement dated July 1, 1992 between Biomatrix,
Inc. and the trustees of the Company, as filed as an Exhibit to
the 1992 annual report on Form 10-K, and incorporated herein by
reference thereto. Management contract or compensatory plan
required to be filed as an exhibit to this form pursuant to Item
14(c) of this report.

10.13 Distribution agreement dated November 9, 1993 between Biomatrix,
Inc. and Syntex Pharmaceuticals International Limited, as filed as
an Exhibit to the 1993 annual report on Form 10-K, and
incorporated herein by reference thereto. (Confidential portions
have been filed separately with the Commission.)

10.14 Loan Agreement between Biomatrix Medical Canada Inc. and Society
de Development Industrial du Quebec, as filed as an Exhibit to the
1993 annual report on Form 10-K, and incorporated herein by
reference thereto.

10.15 Consulting Agreement dated June 1, 1993 between Biomatrix, Inc.
and Julius A. Vida, Ph.D., as filed as an Exhibit to the quarterly
report on Form 10-Q for the quarter ended June 30, 1993, and
incorporated herein by reference thereto. Management contract or
compensatory plan required to be filed as an exhibit to this form
pursuant to Item 14(c) of this report.

10.16 Distribution Agreement dated September 8, 1995, between Biomatrix
Medical Canada Inc. and Rhone-Poulenc Rorer Canada Inc., as filed
as an Exhibit to the quarterly report on Form 10-Q for the quarter
ended September 30, 1995, and incorporated herein by reference
thereto. (Confidential portions have been filed separately with
the Commission.)

10.17 Agreement dated August 29, 1995, between Biomatrix, Inc. and Rory
B. Riggs, as filed as an Exhibit to the quarterly report on Form
10-Q for the quarter ended September 30, 1995, and incorporated
herein by reference thereto.

10.18 Stock Purchase Agreement dated July 11, 1995, between Biomatrix,
Inc. and Rory B. Riggs, as filed as an Exhibit to the quarterly
report on Form 10-Q for the quarter ended September 30, 1995, and
incorporated herein by reference thereto.

10.19 Amendment dated July 10, 1995, to the Consulting Agreement dated
June 1, 1993 between Biomatrix, Inc. and Julius A. Vida, as filed
as an Exhibit to the quarterly report on Form 10-Q for the quarter
ended September 30, 1995, and incorporated herein by reference
thereto. Management contract or compensatory plan required to be
filed as an exhibit to this form pursuant to Item 14(c) of this
report.

19
<PAGE> 22
10.20 1994 Stock Option Plan. Filed as an exhibit to the Company's proxy
statement filed pursuant to Rule 14a-6 dated June 7, 1994, as
filed as an Exhibit to the 1995 annual report on Form 10-K, and
incorporated herein by reference thereto. Management contract or
compensatory plan required to be filed as an exhibit to this form
pursuant to Item 14(c) of this report.

10.21 Non-employee director stock option plan. Filed as an exhibit to
the Company's proxy statement filed pursuant to Rule 14a-6 dated
May 23, 1995, as filed as an Exhibit to the 1995 annual report on
Form 10-K, and incorporated herein by reference thereto.
Management contract or compensatory plan required to be filed as
an exhibit to this form pursuant to Item 14(c) of this report.

10.22 United States Distribution Agreement dated June 14, 1996 between
Biomatrix, Inc. and Collagen Corporation, as filed as an Exhibit
to the quarterly report on Form 10-Q for the quarter ended June
30, 1996 and incorporated herein by reference thereto.
(Confidential treatment requested. Confidential portions have been
omitted and filed separately with the Commission.)

10.23 Restated Distribution Agreement between Biomatrix, Inc. and Syntex
Pharmaceuticals International Limited dated April 9, 1996, as
filed as an Exhibit to the quarterly report on Form 10-Q for the
quarter ended June 30, 1996, and incorporated herein by reference
thereto. (Confidential treatment requested. Confidential portions
have been omitted and filed separately with the Commission.)

10.24 Agreement of Lease, dated April 18, 1996, between Ridgefield
Associates and Biomatrix, Inc., as filed as an Exhibit to the
quarterly report on Form 10-Q for the quarter ended June 30, 1996,
and incorporated herein by reference thereto. (Confidential
treatment requested. Confidential portions have been omitted and
filed separately with the Commission.)

10.25 International Distribution Agreement, dated June 14, 1996, between
Biomatrix, Inc. and Collagen Corporation, as filed as an Exhibit
to the quarterly report on Form 10-Q for the quarter ended June
30, 1996, and incorporated herein by reference thereto.
(Confidential treatment requested. Confidential portions have been
omitted and filed separately with the Commission.)

10.26 Employment Agreement, dated April 2, 1996, between Biomatrix, Inc.
and Rory B. Riggs, as filed as an Exhibit to the quarterly report
on Form 10-Q for the quarter ended June 30, 1996, and incorporated
herein by reference thereto. Management contract or compensatory
plan required to be filed as an exhibit to this form pursuant to
Item 14(c) of this report.

10.27 Amendment dated March 31, 1996 to the Consulting Agreement, dated
June 1, 1993, between Biomatrix Inc. and Julius A. Vida, as filed
as and Exhibit to the quarterly report on Form 10-Q for the
quarter ended June 30, 1996, and incorporated herein by reference
thereto. Management contract or compensatory plan required to be
filed as an exhibit to this form pursuant to Item 14(c) of this
report.

10.28 Restricted Stock Purchase Agreement, date April 2, 1996, between
Biomatrix, Inc. and Rory B. Riggs, as filed as an Exhibit to the
Schedule 13D of Rory B. Riggs filed with the Commission on June
24, 1996 and incorporated herein by reference thereto. Management
contract or compensatory plan required to be filed as an exhibit
to this form pursuant to Item 14(c) of this report.

10.29 Secured Promissory Note, dated April 2, 1996, by Rory B. Riggs and
Biomatrix Inc., as filed as an Exhibit to the Schedule 13D of Rory
B. Riggs filed with the Commission on June 24, 1996 and
incorporated herein by reference thereto. Management contract or
compensatory plan required to be filed as an exhibit to this form
pursuant to Item 14(c) of this report.

10.30 Stock Pledge Agreement, dated April 2, 1996, between Rory B. Riggs
and Biomatrix Inc., as filed as an Exhibit to the Schedule 13D of
Rory B. Riggs filed with the Commission on June 24, 1996 and
incorporated herein by reference thereto. Management contract or
compensatory plan required to be filed as an exhibit to this form
pursuant to Item 14(c) of this report.

20
<PAGE> 23
10.31 Distribution Agreement dated December 17, 1996, between Biomatrix,
Inc. and Boehringer Ingelheim France, S.A. as filed as an Exhibit
to the 1996 annual report on Form 10-K, and incorporated herein by
reference thereto. (Confidential treatment requested. Confidential
portions have been omitted and filed separately with the
Commission.)

10.32 United States Licensing Agreement dated February 7, 1997 between
Biomatrix, Inc. and American Home Products Corporation as filed as
an Exhibit to the quarterly report on Form 10Q for the quarter
ended March 31, 1997, and incorporated herein by reference
thereto. (Confidential treatment requested. Confidential portions
have been omitted and filed separately with the Commission.)

10.33 International Licensing Agreement dated February 7, 1997 between
Biomatrix, Inc. and American Home Products Corporation as filed as
an Exhibit to the quarterly report on Form 10Q for the quarter
ended March 31, 1997, and incorporated herein by reference
thereto. (Confidential treatment requested. Confidential portions
have been omitted and filed separately with the Commission.)

10.34 Supply Agreement dated February 7, 1997 between Biomatrix, Inc.
and American Home Products Corporation as filed as an Exhibit to
the quarterly report on Form 10Q for the quarter ended March 31,
1997, and incorporated herein by reference thereto. (Confidential
treatment requested. Confidential portions have been omitted and
filed separately with the Commission.)

10.35 Trademark License Agreement dated February 7, 1997 between
Biomatrix, Inc. and American Home Products Corporation as filed as
an Exhibit to the quarterly report on Form 10Q for the quarter
ended March 31, 1997, and incorporated herein by reference
thereto. (Confidential treatment requested. Confidential portions
have been omitted and filed separately with the Commission.)

10.36 Form of Restricted Stock Purchase Agreement under the Company's
1997 Restricted Stock Plan as filed as an Exhibit to the quarterly
report on Form 10Q for the quarter ended June 30, 1997, and
incorporated herein by reference thereto. Management contract or
compensatory plan required to be filed as an exhibit to this form
pursuant to Item 14(c) of this report.

10.37 Form of Secured Promissory Note under the Company's 1997
Restricted Stock Plan as filed as an Exhibit to the quarterly
report on Form 10Q for the quarter ended June 30, 1997, and
incorporated herein by reference thereto. Management contract or
compensatory plan required to be filed as an exhibit to this form
pursuant to Item 14(c) of this report.

10.38 Form of Stock Pledge Agreement under the Company's 1997 Restricted
Stock Plan as filed as an Exhibit to the quarterly report on Form
10Q for the quarter ended June 30, 1997, and incorporated herein
by reference thereto. Management contract or compensatory plan
required to be filed as an exhibit to this form pursuant to Item
14(c) of this report.

21 List of Subsidiaries.

23.1 Consent of Coopers & Lybrand L.L.P., independent auditors of the
Company.

27.1 Financial Data Schedules, including restatement of schedules
previously filed to reflect the adoption of SFAS 128, "Earnings
per Share."

- ------------------

REPORT ON FORM 8-K
None.

21
<PAGE> 24
SIGNATURES

Pursuant to the requirements of Section 13 or 15(d) of the Securities
and Exchange Act of 1934, the Registrant has duly caused this report to be
signed on its behalf by the undersigned thereunto duly authorized.

BIOMATRIX, INC.

By: /s/ ENDRE A. BALAZS
----------------------------
(Endre A. Balazs)
Chief Executive Officer, Chief Scientific Officer, Director

Pursuant to the requirements of the Securities Act of 1934, this report
has been signed below by the following persons on behalf of the registrant and
in the capacities and on the dates indicated.

<TABLE>
<CAPTION>
Signature Title Date
--------- ----- ----
<S> <C> <C>
/s/ ENDRE A. BALAZS
------------------------------------------ Chief Executive Officer, Chief March 30, 1998
(Endre A. Balazs) Scientific Officer, Director
(Principal Executive Officer)

/s/ MAXINE SEIFERT
------------------------------------------ Chief Financial Officer March 30, 1998
(Maxine Seifert) (Principal Finance and
Accounting Officer)

/s/ RORY B. RIGGS
------------------------------------------ President, Director March 30, 1998
(Rory B. Riggs)

/s/ JANET L. DENLINGER
------------------------------------------ Executive Vice President, March 30, 1998
(Janet L. Denlinger) Director

/s/ H. STUART CAMPBELL
------------------------------------------ Chairman of the Board of March 30, 1998
(H. Stuart Campbell) Directors

/s/ KURT MARK
------------------------------------------ Director March 30, 1998
(Kurt Mark)

/s/ JUSTIN P. MORREALE
------------------------------------------ Director March 30, 1998
(Justin P. Morreale)

/s/ JULIUS A. VIDA
------------------------------------------ Director March 30, 1998
(Julius A. Vida)
</TABLE>

22
<PAGE> 25
BIOMATRIX, INC. AND SUBSIDIARIES

INDEX TO CONSOLIDATED FINANCIAL STATEMENTS

<TABLE>
<CAPTION>
Consolidated Financial Statements:
Page
----
<S> <C>
Report of Independent Accountants..................................................... F-2

Consolidated Balance Sheets as of December 31, 1997 and 1996.......................... F-3

Consolidated Statements of Operations for the years ended December 31,
1997, 1996 and 1995................................................................. F-4

Consolidated Statements of Changes in Shareholders' Equity for
the years ended December 31, 1997, 1996 and 1995.................................... F-5

Consolidated Statements of Cash Flows for the years ended December 31,
1997, 1996 and 1995................................................................. F-6

Notes to Consolidated Financial Statements............................................ F-7 to F-19
</TABLE>

Financial statement schedules are omitted for the reason that they are not
applicable or the required information is included in the consolidated financial
statements or notes thereto.

F-1
<PAGE> 26
REPORT OF INDEPENDENT ACCOUNTANTS

To the Shareholders and
Board of Directors of
Biomatrix, Inc.

We have audited the accompanying consolidated balance sheets of Biomatrix,
Inc. and subsidiaries as of December 31, 1997 and 1996, and the related
consolidated statements of operations, changes in shareholders' equity, and cash
flows for each of the three years in the period ended December 31, 1997. These
financial statements are the responsibility of the Company's management. Our
responsibility is to express an opinion on these financial statements based on
our audits.

We conducted our audits in accordance with generally accepted auditing
standards. Those standards require that we plan and perform the audit to obtain
reasonable assurance about whether the financial statements are free of material
misstatement. An audit includes examining, on a test basis, evidence supporting
the amounts and disclosures in the financial statements. An audit also includes
assessing the accounting principles used and significant estimates made by
management, as well as evaluating the overall financial statement presentation.
We believe that our audits provide a reasonable basis for our opinion.

In our opinion, the financial statements referred to above present fairly,
in all material respects, the consolidated financial position of Biomatrix, Inc.
and subsidiaries as of December 31, 1997 and 1996 and the consolidated results
of their operations and their cash flows for each of the three years in the
period ended December 31, 1997 in conformity with generally accepted accounting
principles.

COOPERS & LYBRAND L.L.P.

Parsippany, New Jersey
February 23, 1998

F-2
<PAGE> 27
BIOMATRIX, INC. AND SUBSIDIARIES

CONSOLIDATED BALANCE SHEETS

<TABLE>
<CAPTION>
December 31,
-----------------------------
1997 1996
---- ----
<S> <C> <C>
ASSETS
Current assets:
Cash and cash equivalents ................................... $ 17,387,085 $ 3,034,764
Held-to-maturity investments ................................ -- 10,603,358
Accounts receivable, less allowance for doubtful accounts
of $25,500 in 1997 and 1996 ............................. 3,517,112 1,230,456
Inventory, at lower of cost or market ....................... 3,111,351 727,083
Prepaid expenses and other current assets ................... 1,903,528 730,302
------------ ------------

Total current assets ........................................ 25,919,076 16,325,963
Property, plant and equipment, net .............................. 17,780,526 9,506,005
Other assets .................................................... 525,045 162,059
------------ ------------

Total assets ...................................... $ 44,224,647 $ 25,994,027
============ ============

LIABILITIES AND SHAREHOLDERS' EQUITY
Current liabilities:
Current portion of notes payable ............................ $ 162,210 $ 154,566
Current portion of capital lease obligations ................ 16,062 12,842
Accounts payable ............................................ 784,894 724,743
Accrued expenses ............................................ 3,053,770 1,599,419
------------ ------------

Total current liabilities ................................... 4,016,936 2,491,570
Notes payable less current maturities ........................... 935,478 1,127,343
Capital lease obligations less current maturities ............... 4,663,715 4,671,179
------------ ------------

Total liabilities ......................................... 9,616,129 8,290,092
------------ ------------

Commitments and contingent liabilities

Shareholders' equity:
Preferred stock, 3,000 shares authorized; none issued ........ -- --
Common stock, $.0001 par value: 60,000,000 and 20,000,000
authorized; 11,013,035 and 10,587,615 issued and 10,966,888
and 10,584,801 outstanding in 1997 and 1996, respectively .. 1,101 1,059
Additional paid-in capital ...................................... 59,813,585 56,682,755
Notes receivable - related parties .............................. (2,868,538) (2,450,000)
Accumulated deficit ............................................. (19,826,634) (35,564,348)
Equity adjustment from foreign currency translation ............. (1,570,085) (953,571)
Treasury stock, 46,147 and 2,814 shares of common stock at cost
in 1997 and 1996, respectively ............................. (940,911) (11,960)
------------ ------------

Total shareholders' equity ........................ 34,608,518 17,703,935
------------ ------------

Total liabilities and shareholders' equity ........ $ 44,224,647 $ 25,994,027
============ ============
</TABLE>

See notes to consolidated financial statements.

F-3
<PAGE> 28
BIOMATRIX, INC. AND SUBSIDIARIES

CONSOLIDATED STATEMENTS OF OPERATIONS

<TABLE>
<CAPTION>
Years ended December 31,
----------------------------------------------
1997 1996 1995
---- ---- ----
<S> <C> <C> <C>
Net product sales ............................... $ 11,734,908 $ 4,950,652 $ 3,613,769
Income from licenses, royalties, research
contracts and grants ....................... 20,829,348 10,628,260 7,457,096
------------ ------------ ------------
Total revenues ............................. 32,564,256 15,578,912 11,070,865
------------ ------------ ------------

Costs and expenses:
Cost of goods sold ......................... 3,609,907 2,563,060 1,911,426
Research and development expenses .......... 5,927,142 5,484,655 5,136,957
Selling, general and administrative expenses 7,806,392 5,320,162 4,942,946
------------ ------------ ------------
Total costs and expenses .................. 17,343,441 13,367,877 11,991,329
------------ ------------ ------------

Income (loss) from operations ................... 15,220,815 2,211,035 (920,464)

Interest expense ................................ (105,696) (117,465) (107,071)
Interest and miscellaneous income ............... 1,158,595 811,567 808,254
------------ ------------ ------------
Income (loss) before taxes ...................... 16,273,714 2,905,137 (219,281)

Provision for income taxes ...................... 536,000 135,000 --
------------ ------------ ------------
Net income (loss) ............................... $ 15,737,714 $ 2,770,137 $ (219,821)
============ ============ ============

Net income (loss) per share:
Basic ..................................... $ 1.44 $ 0.27 $ (0.02)
============ ============ ============
Weighted average shares outstanding ....... 10,894,769 10,434,230 9,876,587
============ ============ ============

Diluted ................................... $ 1.39 $ 0.25 $ (0.02)
============ ============ ============
Diluted shares outstanding ................ 11,327,206 10,895,026 9,876,587
============ ============ ============
</TABLE>

See notes to consolidated financial statements.

F-4
<PAGE> 29
BIOMATRIX, INC. AND SUBSIDIARIES

CONSOLIDATED STATEMENTS OF CHANGES IN SHAREHOLDERS' EQUITY

<TABLE>
<CAPTION>
Capital stock $.0001 Par Value Equity
----------------------------------- Adjustment Treasury
Common-voting Notes From Stock
-------------------- Additional Receivable- Foreign --------------------
Shares Par Paid-in Related Accumulated Currency Shares
Issued Value Capital Parties Deficit Translation Held Cost
---------- ------- ----------- ------------- ------------- ------------ ------- ----------
<S> <C> <C> <C> <C> <C> <C> <C> <C>
Balance at December 31, 1994 9,472,783 $ 947 $49,146,825 $(38,115,204) $ (836,139) (2,814) $ (11,960)

Sale of Common Stock 550,000 55 3,830,845
Compensatory stock options,
net of forfeitures 44,000
Options exercised 103,166 11 264,553
Adjustments resulting from
translation adjustments 11,157
Net loss - 1995 (219,281)
---------- ------ ----------- ------------ ------------ ----------- ------- ---------
Balance at December 31, 1995 10,125,949 1,013 53,286,223 (38,334,485) (824,982) (2,814) (11,960)

Sale of Common Stock 200,000 20 2,449,980
Compensatory stock options,
net of forfeitures 27,362
Options exercised 261,666 26 919,190
Adjustments resulting from
translation adjustments (128,589)
Note receivable-related party $ (2,450,000)
Net income - 1996 2,770,137
---------- ------ ----------- ------------ ------------ ----------- ------- ---------
Balance at December 31, 1996 10,587,615 1,059 56,682,755 (2,450,000) (35,564,348) (953,571) (2,814) (11,960)

Sale of Common Stock to
Related Parties 133,000 13 2,294,208
Purchase of Treasury Stock (43,333) (928,951)
Compensatory stock options 68,388
Options exercised 292,420 29 768,234
Adjustments resulting from
translation adjustments (616,514)
Note receivable-related
parties (418,538)
Net income - 1997 15,737,714
---------- ------ ----------- ------------ ------------ ----------- ------- ---------
Balance at December 31, 1997 11,013,035 $1,101 $59,813,585 $ (2,868,538) $(19,826,634) $(1,570,085) (46,147) $(940,911)
========== ====== =========== ============ ============ =========== ======= =========
</TABLE>

See notes to consolidated financial statements.

F-5
<PAGE> 30
BIOMATRIX, INC. AND SUBSIDIARIES

CONSOLIDATED STATEMENTS OF CASH FLOWS

<TABLE>
<CAPTION>
December 31,
-----------------------------------------------
1997 1996 1995
---- ---- ----
<S> <C> <C> <C>
Cash flows from operating activities:
Net income (loss) .......................................... $ 15,737,714 $ 2,770,137 $ (219,281)
------------ ------------ ------------
Adjustments to reconcile net income (loss) to
net cash provided by (used in) operating activities:
Depreciation and amortization .......................... 719,230 562,534 534,128
Amortization of deferred income ........................ -- -- (1,943,050)
Stock option compensation .............................. 68,388 27,499 44,000
Change in assets and liabilities:
Accounts receivable ....................................... (2,391,174) (196,177) (604,711)
Inventory ................................................. (2,458,089) (68,971) (56,304)
Prepaid expenses and other current assets ................. (1,185,251) (284,629) (48,629)
Other assets .............................................. (414,398) (49,892) (54,992)
Accounts payable, accrued expenses and deferred income .... 1,220,625 475,702 (169,862)
------------ ------------ ------------
Total adjustments ....................................... (4,440,669) 466,066 (2,299,420)
------------ ------------ ------------
Net cash provided by (used in) operating activities ............. 11,297,045 3,236,203 (2,518,701)
------------ ------------ ------------

Cash flows from investing activities:
Capital expenditures ....................................... (9,140,447) (765,599) (263,592)
Purchases of held-to-maturity investments .................. -- (18,563,530) (6,506,796)
Maturity of held-to-maturity investments ................... 10,603,358 9,558,569 13,646,583
------------ ------------ ------------
Net cash provided by (used in) investing activities ............. 1,462,911 (9,770,560) 6,876,195
------------ ------------ ------------

Cash flows from financing activities:
Payments of notes payable and capital leases ............... (139,180) (230,949) (132,958)
Stock options exercised .................................... 768,263 919,216 264,563
Repurchase of common stock ................................. (928,951) -- --
Sale of common stock ....................................... 1,890,000 -- 3,830,900
------------ ------------ ------------
Net cash provided by financing activities ....................... 1,590,132 688,267 3,962,505
------------ ------------ ------------
Effect of exchange rate changes on cash ......................... 2,233 (8,015) 87,542
------------ ------------ ------------
Net increase (decrease) in cash and cash equivalents ............ 14,352,321 (5,854,105) 8,407,541
Cash and cash equivalents at beginning of period ................ 3,034,764 8,888,869 481,328
------------ ------------ ------------
Cash and cash equivalents at end of period ...................... $ 17,387,085 $ 3,034,764 $ 8,888,869
============ ============ ============

Supplemental cash flow data:
Interest paid, net of capitalized interest ................. $ 105,696 $ 117,465 $ 107,071
Income taxes paid .......................................... $ 220,000 $ 135,000 --
Non-cash investing and financing:
Capital expenditures financed by capital lease obligations.. $ -- $ 4,681,350 --
Sale of common stock financed with note receivable ......... $ 418,538 $ 2,450,000 --
</TABLE>

See notes to consolidated financial statements.

F-6
<PAGE> 31
BIOMATRIX, INC. AND SUBSIDIARIES

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

1. NATURE OF OPERATIONS

Biomatrix, Inc. (the "Company") was founded in 1981 to develop,
manufacture and commercialize a series of proprietary viscoelastic products made
of biological polymers called hylans for use in therapeutic medical applications
and skin care. Hylans are chemically modified forms of the naturally occurring
hyaluronan (also known as hyaluronic acid or sodium hyaluronate). Hylans are the
second generation of viscoelastics used in medicine, and are characterized by
significantly enhanced physical (rheological) properties (elasticity, viscosity
and pseudoplasticity) as compared to naturally occurring hyaluronan, from which
the first generation viscoelastics are made. The discovery of hylans has allowed
the Company to develop a range of patented products with superior viscoelastic
properties in the forms of fluids, gels and solids. The Company's operations
consist of therapeutic medical products, skin care intermediate products and
toxicity testing. The Company's business is subject to certain risks and
uncertainties, including but not limited to obtaining and enforcing patents, the
uncertainties associated with the regulatory approval process, manufacturing,
competition, product liability, reimbursement, and successful commercialization
of its products.

2. SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES

Basis of Consolidation

The consolidated financial statements include the accounts of the Company
and its wholly owned subsidiaries, Biomatrix UK, Biomatrix France SARL,
Biomatrix Switzerland GmbH, Biomatrix Svenska AB, and its majority-owned
subsidiary, Biomatrix Medical Canada Inc. All significant intercompany accounts
and transactions have been eliminated in consolidation.

Property, Plant and Equipment

Property, plant and equipment is recorded at cost.

Depreciation and Amortization

Building, research laboratory equipment, office equipment and
manufacturing equipment are depreciated on the straight-line method over their
estimated useful lives. Capital leases and leasehold improvements are amortized
on the straight-line method over the estimated useful life of the property or
the terms of the related lease, whichever is shorter. Expenditures for
additions, major renewals and improvements are capitalized and expenditures for
maintenance and repairs are charged to expense as incurred. When assets are
retired or otherwise disposed of, the cost and accumulated depreciation are
removed from the accounts and the resulting gain or loss is recognized in
income for the period.

Impairment of Long-Lived Assets

Long-lived assets are reviewed for impairment whenever events or changes
in circumstances indicate that the carrying amount may not be recoverable. If
the sum of the expected future undiscounted cash flows is less than the carrying
amount of the asset, a loss is recognized. There were no impaired long-lived
assets at December 31, 1997.

Cash and Cash Equivalents

Cash and cash equivalents include highly liquid short-term investments in
money market funds, at cost, and U.S. Government or Government Agency
securities, at amortized cost, purchased with a maturity of less than three
months.

Fair Value of Financial Instruments

Cash, accounts receivable, accounts payable and accrued liabilities are
reflected in the financial statement at fair value because of the short-term
maturity of those instruments. The fair value of the Company's notes payable and
capital lease obligations (including current installments) are estimated based
on the current rate offered to the Company for debt of the same remaining
maturities. The estimated fair value of the Company's notes payable and capital
lease obligations approximates the carrying value at December 31, 1997 and 1996.

F-7
<PAGE> 32
BIOMATRIX, INC. AND SUBSIDIARIES

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS - (CONTINUED)

2. SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (CONTINUED)

Inventory

Inventory is stated at the lower of cost or market and costs are removed
on a first-in first-out (FIFO) basis.

Investments

Investments, which typically consist of U.S. Government and Government
Agency Securities, are classified as held-to-maturity and are reported at
amortized cost, which approximates market.

Revenue Recognition

The Company's product revenue is recognized at the time the products are
shipped. Revenue from non-refundable license payments is recognized in the
period earned, which is when all related material commitments have been
satisfied. Research contract revenue is recognized at the time the service is
performed.

Risks and Uncertainties

The preparation of financial statements in conformity with generally
accepted accounting principles requires management to make estimates and
assumptions that affect the amounts reported in the financial statements and
accompanying notes. Actual results could differ from those estimates.

Income Taxes

Deferred taxes are provided on the liability method, in accordance with
SFAS No. 109, whereby deferred tax assets are recognized for deductible
temporary differences, and operating loss and tax credit carryforwards and
deferred tax liabilities are recognized for taxable temporary differences.
Deferred tax assets are reduced by a valuation allowance, when, in the opinion
of management, it is more likely than not that some portions or all of the
deferred tax assets will not be realized. Deferred tax assets and liabilities
are adjusted for the effects of changes in tax laws and rates on the date of
enactment.

Foreign Currency Translation

The assets and liabilities of the Company's subsidiaries are translated
into U.S. dollars at year-end exchange rates and revenue and expense items are
translated at average rates of exchange prevailing during the year. Resulting
translation adjustments are accumulated in a separate component of shareholders'
equity. Gains and (losses) resulting from foreign currency transactions
(transactions denominated in a currency other than the Company's functional
currency) are included in miscellaneous income.

Net Income (Loss) Per Common Share

The Company has adopted Statement of Financial Accounting Standards No.
128 "Earnings per Share" which requires the presentation of basic earnings per
share and diluted earnings per share. Basic net income per share is computed by
dividing net income by the weighted-average common shares outstanding for the
period. Diluted net income per share is reflective of all common share
equivalents. Common share equivalents have not been included when the Company
generated a loss because their effect would be anti-dilutive. Prior periods have
been restated to reflect the new standard. A reconciliation of weighted average
shares outstanding from basic to diluted is as follows:

<TABLE>
<CAPTION>
1997 1996 1995
---- ---- ----
<S> <C> <C> <C>
Weighted average shares outstanding - Basic 10,894,769 10,434,230 9,876,587
Dilutive effect of stock options 432,437 460,796 --
---------- ---------- ---------
Weighted average shares outstanding - Diluted 11,327,206 10,895,026 9,876,587
========== ========== =========
</TABLE>

Reclassification

Certain amounts in the 1996 and 1995 consolidated statements of operations
and the 1996 consolidated balance sheet have been reclassified in order to
conform to the 1997 presentation.

F-8
<PAGE> 33
BIOMATRIX, INC. AND SUBSIDIARIES

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS - (CONTINUED)

3. INVENTORIES

Inventories at December 31, 1997 and 1996 consisted of:

<TABLE>
<CAPTION>
1997 1996
---- ----
<S> <C> <C>
Finished goods ....................... $ 630,316 $148,925
Work-in-process ...................... 1,568,682 300,704
Raw materials ........................ 912,353 277,454
---------- --------
$3,111,351 $727,083
========== ========
</TABLE>

4. NOTES RECEIVABLE - RELATED PARTIES

Notes receivable - related parties relate to the acquisition of common
stock of the Company at fair market value by several officers of the Company
during 1997 and 1996. The notes are with recourse and are payable with simple
interest upon maturity. The notes mature in April 2000 and May 2007 in the
amounts of $2,450,000 and $418,538, respectively. All notes issued during 1997
have been for common stock issued pursuant to the Company's 1997 Restricted
Stock Plan.

5. PROPERTY, PLANT AND EQUIPMENT

Property, plant and equipment at December 31, 1997 and 1996 consisted of:

<TABLE>
<CAPTION>
Estimated
1997 1996 Useful Life
---- ---- -----------
<S> <C> <C> <C>
Land and building ............................ $ 2,367,451 $ 2,470,753 25 years*
Research laboratory equipment ................ 2,111,897 1,682,086 5-10 years
Construction in progress ..................... 11,840,269 5,017,089 N/A
Manufacturing equipment ...................... 3,167,458 1,959,203 5-10 years
Office equipment ............................. 1,449,192 883,630 3-10 years
Leasehold improvements ....................... 1,075,688 1,075,688 1-7 years
------------ -----------
22,011,955 13,088,449
Less accumulated depreciation and amortization (4,231,429) (3,582,444)
------------ -----------
$ 17,780,526 $ 9,506,005
============ ===========
</TABLE>

* Buildings only

Depreciation expense for the three years ended December 31, 1997, 1996 and
1995 was, $719,230, $562,534 and $534,128, respectively. Capitalized interest
for the years ended December 31, 1997 and 1996 was $417,307 and $94,940,
respectively. Repairs and maintenance expenses for the three years ended
December 31, 1997, 1996 and 1995 were $138,864, $125,715 and $87,882,
respectively.

Assets recorded under capital leases as of December 31, 1997 and 1996 are
included in construction in progress in the amount of $4,591,145 and office
equipment in the amount of $90,205. Accumulated amortization related to the
office equipment under capital lease was $21,048 and $9,020 as of December 31,
1997 and 1996, respectively.

6. ACCRUED EXPENSES

Accrued expenses at December 31, 1997 and 1996 consisted of:

<TABLE>
<CAPTION>
Accrued Expenses: 1997 1996
---- ----
<S> <C> <C>
Environmental expenses...................................... $ 685,610 $ 700,610
Accrued personnel expenses.................................. 1,014,518 546,031
Taxes payable............................................... 316,000 -
Other accrued expenses...................................... 1,037,642 352,778
---------- ----------
$3,053,770 $1,599,419
========== ==========
</TABLE>

F-9
<PAGE> 34
BIOMATRIX, INC. AND SUBSIDIARIES

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS - (CONTINUED)

7. LONG-TERM DEBT AND CAPITAL LEASE OBLIGATIONS

<TABLE>
<CAPTION>
Notes Payable: 1997 1996
---- ----
<S> <C> <C>
Mortgage note, payable in monthly installments through
July 2001................................................ $ 448,174 $ 501,901
Construction and equipment loan............................ 649,514 780,008
Capital lease obligations...................................... 4,679,777 4,684,021
----------- ----------
Total ............................................ 5,777,465 5,965,930
Less current maturities..................................... (178,272) (167,408)
----------- ----------
$ 5,599,193 $5,798,522
=========== ==========
</TABLE>

In connection with its acquisition of a manufacturing facility, the
Company's majority-owned Canadian subsidiary obtained a $668,870 mortgage with
an annual interest rate of 11.25% and final payment of $525,053 due in June
1996. In July 1996, the Company refinanced the final payment with another
mortgage that accrues interest at an annual rate of 9.5% and has a final payment
of $323,785 due in June 2001.

The Company's majority-owned Canadian subsidiary obtained a $950,069
construction and manufacturing equipment loan from the Canadian government of
which $840,064 and $110,005 was funded in 1993 and 1994, respectively. Interest
on the loan accrues at the prevailing annual variable rate, which was
approximately 7.5% at December 31, 1997 and 7% at December 31, 1996. In January
1996, the Company amended the repayment terms of the agreement, whereby the
Company will make quarterly principal payments and a final payment in 2001. The
principal payments shall correspond to 30% of the Canadian subsidiary's
quarterly net profit (excluding depreciation), with an annual maximum of
$167,800 and an annual minimum of $97,900. The loan agreement contains covenants
that require the maintenance of certain financial ratios by the Canadian
subsidiary.

In September 1996, the Company entered into a capital lease of a building
in which the Company intends to locate its U.S. manufacturing facility. This
lease has been accounted for as a capital lease and has an imputed interest rate
of approximately 9%. Within the first three years of this 10-year lease, the
Company has an option to acquire this building at a price of approximately
$4,500,000. Should the Company not exercise its option within this three- year
period, the landlord has the right to require the purchase by the Company of
this building for approximately the same price.

Future minimum payments due under the note payable, mortgage and capital
lease obligations are as follows at December 31, 1997:

<TABLE>
<CAPTION>
Year Amount
---- ------
<S> <C>
1998...................................................... $ 643,254
1999...................................................... 5,174,395
2000...................................................... 199,971
2001...................................................... 684,586
----------
Total minimum payments.................................... $6,702,206
Less - amount representing interest....................... (924,741)
----------
Principal obligations..................................... 5,777,465
Less - current portion.................................... (178,272)
----------
$5,599,193
==========
</TABLE>

F-10
<PAGE> 35
BIOMATRIX, INC. AND SUBSIDIARIES

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS - (CONTINUED)

7. LONG-TERM DEBT AND CAPITAL LEASE OBLIGATIONS (CONTINUED)

Line of Credit

The Company has a $387,777 credit agreement with a Canadian bank with an
interest rate at prime + 1/2 %. There were no borrowings outstanding at
December 31, 1997.

8. CAPITAL STOCK

On March 2, 1995, the Company completed a private sale of 250,000 shares
of common stock to Recordati Industria Chimica e Farmaceutica S.p.A.
("Recordati"). Net proceeds to the Company related to this sale were $2,000,000.
In July 1997, the Company repurchased 43,333 shares of common stock from
Recordati. This purchase required approximately $929,000 of funds and these
shares are included at cost on the balance sheet as treasury stock.

On July 19, 1995, the Company completed a private sale of 300,000 shares
of common stock at fair market value to a member of the Company's Board of
Directors. Net proceeds to the Company related to this sale were
$1,830,900. On April 2, 1996, the Company completed a private sale of 200,000
shares of common stock at fair market value to an officer of the Company. The
aggregate purchase price of $2,450,000 was financed in full with a full recourse
promissory note issued from the Company. On May 29, 1997, the Company completed
a sale of 28,000 shares of restricted common stock to several officers and
directors of the Company. The aggregate purchase price of $418,538 was financed
with full recourse promissory notes issued from the Company. On June 30, 1997,
the Company completed a sale of 105,000 shares of restricted common stock at
fair market value to several officers of the Company. Proceeds to the Company
related to this sale were $1,890,000.

The 3,000 shares of authorized preferred stock are issuable by the Board
of Directors. The terms, designations and other criteria are determinable by the
Board of Directors upon issuance.

In June 1991, Biomatrix, Inc. capitalized Biomatrix Medical Canada
("BMC"). In connection with this transaction additional capital was raised
through a Canadian venture capital firm for which it received 62,500 shares of
Class A stock in BMC. The rights attached to the Class A stock are identical to
the common stock except there is a liquidation preference over the common stock
and a right to exchange the Class A stock into 38,461 shares of Biomatrix, Inc.
common stock. These shares are exchangeable at the discretion of the venture
capital firm, and as such are included in the basic and diluted earnings per
share calculation.

9. INCOME TAXES

<TABLE>
<CAPTION>
Year Ended December 31,
--------------------------------------------
1997 1996 1995
---- ---- ----
<S> <C> <C> <C>
Income (loss) before income taxes:
Domestic ................... $ 17,213,000 $ 3,881,000 $(1,185,000)
Foreign .................... (939,000) (976,000) 966,000
------------ ----------- -----------
$ 16,274,000 $ 2,905,000 $ (219,000)
============ =========== ===========
Income tax provision:
Domestic, Federal .......... $ 350,000 $ 135,000 --
Domestic, State ............ 186,000 -- --
Foreign .................... -- -- --
------------ ----------- -----------
$ 536,000 $ 135,000 --
============ =========== ===========
</TABLE>

F-11
<PAGE> 36
BIOMATRIX, INC. AND SUBSIDIARIES

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS - (CONTINUED)

9. INCOME TAXES (CONTINUED)

A reconciliation of the United States federal statutory rate to the Company's
effective tax rate for the years ended December 31, 1997, 1996, and 1995 is as
follows:

<TABLE>
<CAPTION>
1997 1996 1995
---- ---- ----
<S> <C> <C> <C>
Statutory federal corporate rate ................. 35.0% 34.0% 34.0%
State income taxes, net of federal tax benefit ... 1.0 -- --
Foreign taxes .................................... 2.0 -- --
Benefit of net operating losses .................. (35.8) (34.0) (34.0)
Change in valuation allowance .................... (1.1) -- --
Alternative minimum tax .......................... 2.2 4.6 --
----- ----- -----
Effective tax rate ............................... 3.3% 4.6% 0.0%
===== ===== =====
</TABLE>

Temporary differences and carryforwards which give rise to deferred tax
assets are as follows:

<TABLE>
<CAPTION>
Deferred Tax Assets
--------------------------------
1997 1996
---- ----
<S> <C> <C>
Net operating losses ................... $ 4,517,000 $ 8,729,000
Research credits ....................... 2,809,000 2,490,000
Environmental reserve .................. 302,000 280,000
Depreciation ........................... 316,000 160,000
Alternative minimum tax credit ......... 348,000 135,000
Other .................................. 1,146,000 1,206,000
------------ ------------
9,438,000 13,000,000
Valuation allowance ................. (9,438,000) (13,000,000)
------------ ------------
Total deferred taxes .......... $ -- $ --
============ ============
</TABLE>

The Company's valuation allowance of $9,438,000 was provided on the
deferred tax assets due to the uncertainty of realization.

The Company has available U.S. federal net operating loss carryforwards at
December 31, 1997 of approximately $6,505,000 which expire at various times from
December 31, 2002 through December 31, 2010. The tax benefits related to
approximately $2,779,000 of the U.S. federal net operating losses at December
31, 1997 relate to stock option deductions which will be credited to additional
paid in capital when recognized. The Company has foreign federal net operating
loss carryforwards of approximately $6,033,000 which expire at various times
from December 31, 2001 through December 31, 2004 and foreign provincial net
operating loss carryforwards of approximately $2,845,000 which expire at various
times from December 31, 2001 through December 31, 2004. In addition, the Company
has U.S. and foreign tax credits carryovers at December 31, 1997 of
approximately $2,899,000 and $258,000 respectively. The U.S. tax credits expire
at various times beginning December 31, 1998 through December 31, 2012 while the
alternative minimum tax credit and foreign tax credits carryover indefinitely.

F-12
<PAGE> 37
BIOMATRIX, INC. AND SUBSIDIARIES

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS - (CONTINUED)

10. COMMITMENTS

Operating Lease

The Company occupies office, laboratory and manufacturing space under a
lease expiring in July 1999. Rent expense for operating leases charged to
operations for the years ended December 31, 1997, 1996 and 1995 approximated
$475,525, $440,441 and $419,693, respectively. Future minimum operating lease
payments for the facility and other items are:

<TABLE>
<S> <C>
1998............................................ $ 440,594
1999............................................ 233,760
2000............................................ 34,260
2001............................................ 17,130
---------
Total minimum obligations....................... $ 725,744
=========
</TABLE>

License Agreements

In November 1993 and June 1994, the Company entered into license and
distribution agreements with Syntex Pharmaceuticals International Limited
("Syntex") to market Synvisc in selected European countries and South Africa. In
return, for the exclusive marketing rights, Syntex paid up-front payments in
1993 and 1994 of $1,230,000, and $5,003,125, respectively. Subsequent to these
agreements, Syntex was acquired by Roche AB, ("Roche"), a subsidiary of F.
Hoffmann-LaRoche Ltd. In 1995, the Company received approval to market Synvisc
in the European Economic Area ("EEA") and as a result, the amount of revenue
previously included in deferred income, $1,030,000, was earned, and accordingly
is included in income from licenses in 1995. Subsequent to the acquisition of
Syntex by Roche, in the fourth quarter of 1995 the Company signed an agreement
with Roche reacquiring the marketing rights to Synvisc for all countries
identified in the previous agreements, except for Sweden and South Africa. The
Company received a non-refundable initial payment in 1995 and a non-refundable
final payment in 1996 in connection with the finalization of this agreement,
which amounts have been included in income from licenses in the respective
years.

In March 1995, the Company entered into a distribution agreement with
Recordati. The agreement provides Recordati with exclusive marketing rights for
Synvisc in Italy.

In September 1995, the Company entered into a distribution agreement with
Rhone-Poulenc Rorer Canada Inc. ("RPR"). The agreement provides RPR with
exclusive marketing rights for Synvisc in Canada. In return, in 1995, the
Company received an up-front non-refundable license fee payment of $3,500,000,
which amount has been included in income from licenses, and could receive a
one-time milestone payment of $2,000,000 if sales reach a certain level.
Additionally, the Company manufactures and supplies Synvisc for a contractual
percentage of RPR's sales price.

In June 1996, the Company entered into a distribution agreement with
Collagen Corporation ("Collagen"). The agreement provides Collagen with
exclusive marketing rights for Hylaform in Europe, Canada, Japan, Australia and
other select countries. In return, the Company received an up-front,
non-refundable payment of $5,000,000 in consideration of the costs and expenses
that have been incurred by the Company related to the research and development
of Hylaform. The Company will also receive a royalty based upon sales of
Collagen's dermal augmentation products as well as an additional royalty on the
potential growth of Collagen's total dermal augmentation business. Additionally,
the Company manufactures and supplies Hylaform to Collagen for a contractual
percentage of Collagen's sales price. The Company has also entered into a
distribution agreement with Collagen for the United States. Under such
agreement, Collagen has an option for exclusive distribution rights to Hylaform
in the United States for an additional payment of $7,000,000, upon and subject
to, FDA approval.

F-13
<PAGE> 38
BIOMATRIX, INC. AND SUBSIDIARIES

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS - (CONTINUED)

10. COMMITMENTS (CONTINUED)

In December 1996, the Company entered into a distribution agreement with
Boehringer Ingelheim France, S.A. ("Boehringer Ingelheim"). The agreement
provides Boehringer Ingelheim with exclusive marketing rights for Synvisc in
France. In return, the Company received an up-front non-refundable payment of
$1,000,000, which has been included in income from licenses in 1996 and could
receive milestone payments of up to $7,000,000 if sales reach certain levels.
The Company manufactures and supplies Synvisc to Boehringer Ingelheim for a
contractual percentage of Boehringer Ingelheim's sales price. Additionally,
Boehringer Ingelheim reimburses the Company, up to a fixed amount and for a
certain period of time, for its costs of maintaining a team of area business
consultants to assist in selling Synvisc in France.

In February 1997, the Company entered into a distribution agreement with
Wyeth-Ayerst Laboratories ("Wyeth"), a division of American Home Products. The
agreement provides Wyeth with exclusive marketing rights to Synvisc in the
United States, Germany, Austria, Spain, Portugal, Greece and certain countries
in the Middle East and Central Europe. In 1997, the Company received various
non-refundable payments totaling $17,000,000. The Company is expecting to
receive a milestone payment of $6,000,000 in the fourth quarter of 1998 and
could receive additional payments in the future if sales reach certain levels.
The Company manufactures and supplies Synvisc to Wyeth for a contractual
percentage of Wyeth's sales price. Additionally, Wyeth reimburses the Company,
up to a fixed amount and for a certain period of time, for its costs of
maintaining a team of area business consultants to assist in selling Synvisc in
Europe and the United States.

In April 1997, the Company entered into a distribution agreement with
Bayer AG ("Bayer"). The agreement provides Bayer with exclusive marketing rights
to Synvisc in Australia, Indonesia, Israel, Malaysia, New Zealand, Singapore,
Taiwan and Thailand. In return the Company received an up-front non-refundable
payment of $3,000,000 and could receive a milestone payment of $2,000,000 upon
certain approvals or if sales reach a certain level. The Company will
manufacture and supply Synvisc to Bayer for a contractual percentage of Bayer's
sales price. Additionally, Bayer will reimburse the Company, up to a fixed
amount and for a certain period of time, for its costs of maintaining several
area business consultants to assist in selling Synvisc in certain countries.

Under the terms of separate agreements with each of three shareholders,
the Company is required to pay a 5% royalty on sales of three hylan products
used in skin care applications. These royalties aggregated approximately
$47,009, $49,081, and $43,500 for the years ended December 31, 1997, 1996 and
1995, respectively.

Research and Development Agreements

The Company entered into agreements with Pharmacia & Upjohn, Inc.
("Pharmacia") in 1992, and granted Pharmacia an exclusive worldwide license to
use, manufacture, market and sell its hylan fluid for use in human ophthalmic
viscosurgery. Under the terms of the agreements, the Company recorded royalty
revenue of $500,000 and $915,681 in 1996 and 1995, respectively. In July 1996,
under the terms of the agreement, Pharmacia exercised its right to terminate
this agreement effective March 1996 and in connection with the termination paid
the Company $1,000,000 which has been included in income from royalties for the
year ended December 31, 1996.

In July 1991, the Company entered into an agreement with Pharmacia to
perform certain toxicity testing. The Company received $579,348, $542,520 and
$494,400 of research and development revenues relating to this testing for the
years ended December 31, 1997, 1996, and 1995, respectively. Such amounts have
been included in research contract revenue.

F-14
<PAGE> 39
BIOMATRIX, INC. AND SUBSIDIARIES

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS - (CONTINUED)

10. COMMITMENTS (CONTINUED)

During February 1990, the Company and its wholly owned subsidiary,
Biomatrix Svenska AB, entered into an agreement with a Swedish Limited
Partnership, Up-Will Investor KB ("Up-Will"). Up-Will invested in Biomatrix
Svenska AB in order that the Company could pursue the obtainment of regulatory
approvals to manufacture and market Synvisc in Germany, France, Spain and the
United Kingdom. Up-Will provided the Company Svenska AB with a total of
approximately $1.5 million. In return, Up-Will shall receive a royalty from the
Company equal to 6% of all net sales of Synvisc in the countries referred to
above, for a period of 10 years from the date of first commercial sale in each
country, regardless of whether the sales are made by the Company, Biomatrix
Svenska AB or another party. At December 31, 1997, sales of Synvisc had been
made in several of the agreement territories and therefore, royalties have been
earned and accrued. The Company has the option to acquire all partnership
interests of Up-Will at any time on three months' prior notice for cash equal to
the investment plus an amount sufficient to provide Up-Will with a 46% rate of
return, compounded annually, exclusive of royalties or any other payments.

11. STOCK OPTIONS

The Company has two fixed option plans which reserve shares of common
stock for issuance to executives, employees and directors. The Company applies
the provisions of Accounting Principles Board Opinion ("APB") No. 25 and related
interpretations in accounting for its stock based compensation plans.
Accordingly, compensation expense has been recognized to the extent applicable
in the financial statements with respect to the two plans in accordance with APB
25. Had compensation cost for the Company's two stock option plans been
determined based on the fair value at the grant date for awards in 1997, 1996
and 1995 consistent with the provisions of Statement of Financial Accounting
Standards No. 123 "Accounting For Stock Based Compensation," the Company's net
earnings and earnings per share would have been reduced to the pro forma amounts
indicated below:

<TABLE>
<CAPTION>
1997 1996 1995
---- ---- ----
<S> <C> <C> <C>
Net income (loss) - as reported ................... $15,737,714 $2,770,137 $(219,821)
Net income (loss) - pro forma .................... 14,077,987 2,155,492 (379,126)
Net income (loss) per share - as reported (basic) . 1.44 0.27 (0.02)
Net income (loss) per share - pro forma (basic) .. 1.29 0.20 (0.04)
Net income (loss) per share - as reported (diluted) 1.39 0.25 (0.02)
Net income (loss) per share - pro forma (diluted) . 1.24 0.19 (0.04)
</TABLE>

Since option grants awarded during 1997, 1996 and 1995 vest over several
years and additional awards are expected to be issued in the future, the pro
forma results shown above are not likely to be representative of the effects on
future years of the application of the fair value based method.

The fair market value of each option grant is estimated on the date of
grant using the Black-Scholes option-pricing model with the following
weighted-average assumptions used for grants in 1997: dividend yield of 0%;
expected volatility of 70%; risk-free interest rate of 5.85 to 6.79%; and
expected lives of 6 years; and for grants in 1996 and 1995: dividend yield of
0%; expected volatility of 80%; risk-free interest rate of 5.43 to 6.66%; and
expected lives of 6.5 years.

Under the amended plan approved by the shareholders in May 1997, the total
number of shares of common stock that may be granted is 2,500,000. In May 1995,
the shareholders approved a Stock Option Plan for Non-Employee Directors of the
Company. This plan authorizes the granting of options on 100,000 shares of
common stock to directors who are not employees of the Company, who will
automatically receive an option to acquire 6,000 shares upon election or
re-election to the Board.

F-15
<PAGE> 40
BIOMATRIX, INC. AND SUBSIDIARIES

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS - (CONTINUED)

11. STOCK OPTIONS (CONTINUED)

These plans provide that shares granted come from the Company's
authorized but unissued or reacquired common stock. The price of the options
granted pursuant to these plans is generally equal to the fair market value of
the shares on the date of grant. The options are generally exercisable over four
to five years. The options expire ten years from the grant date.

Information regarding these option plans for 1997, 1996 and 1995 is as follows:

<TABLE>
<CAPTION>
1997 1996 1995
-------------------------- ---------------------------- ---------------------------
Weighted- Weighted- Weighted-
Average Average Average
Exercise Exercise Exercise
Shares Price Shares Price Shares Price
--------------- --------- --------------- ---------- --------------- ---------
<S> <C> <C> <C> <C> <C> <C>
Options outstanding,
beginning of year ....... 816,527 $ 6.12 942,866 $ 3.65 1,042,183 $ 3.32
Options exercised ............ (292,420) 2.63 (261,666) 3.10 (103,166) 2.56
Options granted .............. 410,800 17.67 175,300 15.32 71,700 7.50
Options canceled ............. (7,550) 9.67 (39,973) 5.29 (67,851) 4.27
Options outstanding,
end of year ............. 927,357 $12.29 816,527 $ 6.12 942,866 $ 3.65

Option price range at
end of year ............. $1.00 to $32.00 $1.00 to $17.25 $2.00 to $12.00

Options exercisable,
end of year ............. 319,407 $ 6.12 515,646 $ 3.18 667,263 $ 2.92

Option price range for
exercised shares ........ $1.00 to $17.25 $2.00 to $7.50 $2.00 to $4.75

Options available for grant
at end of year .......... 840,483 743,733 372,830
Weighted-average fair value
of options granted during
the year ................ $11.98 $11.67 $5.62
</TABLE>

The following table summarizes information about stock options at December
31, 1997:

<TABLE>
<CAPTION>
Options Outstanding Options Exercisable
---------------------------------------------- ----------------------------
Weighted-
Average Weighted- Weighted-
Number Remaining Average Number Average
Range of Outstanding Contractual Exercise Exercisable Exercise
Exercise Prices at 12/31/97 Life Price at 12/31/97 Price
- --------------- ----------- ----------- ---------- ----------- ---------
<S> <C> <C> <C> <C> <C>
$ 1.00 - $ 2.00 57,642 5.34 $ 1.97 57,642 $ 1.97
$ 4.63 - $ 4.75 278,365 6.46 4.74 201,190 4.73
$ 11.25 - $15.88 281,050 9.03 12.07 41,750 13.34
----
$17.25 - $32.00 310,300 9.28 21.19 18,825 17.52
</TABLE>

Compensation expense of $68,388, $27,499 and $44,000 was recorded for the
years ended December 31, 1997, 1996 and 1995, respectively, in accordance with
APB 25.

F-16
<PAGE> 41
BIOMATRIX, INC. AND SUBSIDIARIES

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS - (CONTINUED)

12. RELATED PARTY TRANSACTIONS

Included in accrued expenses at December 31, 1997 and 1996 is an amount of
$47,009 and $49,081, respectively, relating to unpaid royalties to shareholders.
Related party royalty expenses for the three years ended December 31, 1997, 1996
and 1995 were $47,009, $49,081 and $43,500, respectively.

In July 1995, the Company received $1,800,000 related to the private sale
of equity securities to a member of the Company's Board of Directors. In April
1996, the Company entered into a private sale of equity securities with an
officer of the Company for $2,450,000. In May 1997 and June 1997, the Company
entered into the private sale of restricted equity securities with several
officers and directors of the Company for $418,538 and $1,890,000, respectively.
Included in other assets at December 31, 1997 and 1996 is $274,780 and $110,250,
respectively, related to interest receivable for notes issued to officers for
the purchase of the Company's common stock.

13. CONTINGENCY

In August 1990, the Company received a notice from the Pennsylvania
Department of Environmental Resources ("DER") that it is one of approximately
1,000 potentially responsible parties ("PRPs") that may have clean-up
responsibility at the Industrial Solvents and Chemical Company site in York
Haven, Pennsylvania (the "Site"). During the late 1980s, the Company, through a
licensed waste disposal transport company, shipped industrial solvents to the
Site, which was operating as a recycling facility. The DER reviewed hazardous
waste found at the Site as well as the DER's own records in order to identify
additional PRPs and to quantify each PRP's volumetric contributions. The Company
is a member of a steering committee that consists of many PRPs. Although neither
the total clean-up cost nor the portion of the total clean-up cost assigned to
each PRP has been determined, the Company estimated, based upon the advice of a
consultant, that its liability would be approximately $780,000. Further, the
same consultant has reported to the Company that there is less than a 10% chance
that its liability might exceed $1,070,033. During the second quarter of 1995
the Company paid its first assessment for clean-up costs of $79,390.
Additionally, the Company paid $15,000 during the first quarter of 1997;
therefore, the reserve at December 31, 1997 was $685,610. The steering committee
for the PRPs has prepared a buy-out proposal pursuant to a consent order with
the DER. This buy-out proposal identifies each PRP's assigned portion of assumed
total clean-up costs. The Company's assigned portion of the assumed clean-up
costs within the proposal is currently less than its reserve, however there can
be no assurance that the proposal will be accepted. When the final remedy is
selected by the DER, the Company plans to settle out of the matter pursuant to
the buyout proposal. The Company will monitor this situation and make any
necessary adjustments to the reserve once additional information is available.

Litigation

In October 1996, Michael Jarcho ("Jarcho") filed suit in the United States
District Court for the Southern District of California seeking to recover
damages and declaratory judgment for the alleged breach by the Company of
Jarcho's consulting agreement. A consulting agreement had been entered into
between the Company and Jarcho on December 2, 1988. The agreement contains
certain royalty provisions for products that result from Jarcho's consultancy.
Jarcho contends, inaccurately in the Company's view, that Hylaform resulted from
his consultancy. Jarcho seeks compensatory damages of $300,000 plus a royalty on
the Company's net sales of Hylaform as well as punitive damages and recovery of
attorney fees. The Company believes that no royalties are owed Jarcho as a
result of Hylaform sales. Jarcho's case was dismissed on January 10, 1997, on
the grounds that the agreement requires such disputes to be brought exclusively
in New Jersey state court. Jarcho moved for a partial reconsideration of the
decision, the Company opposed that request, and the request was denied. On June
16, 1997 Jarcho filed suit in New Jersey state court. The Company intends to
defend this matter vigorously. The Company has not made any provision in the
accompanying consolidated financial statements for any liability that might
result.

F-17
<PAGE> 42
BIOMATRIX, INC. AND SUBSIDIARIES

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS - (CONTINUED)

14. EMPLOYEE BENEFIT PLAN

The Company adopted a defined contribution retirement savings plan
effective January 1, 1992. Pursuant to Section 401k of the Internal Revenue
Code, if a participant decides to contribute, a portion of the contribution can
be matched by the Company. Company contributions and plan expenses paid by the
Company on behalf of the plan amounted to $33,268, $22,370 and $14,281 for the
year ended December 31, 1997, 1996, and 1995, respectively.

Presently, the Company does not offer its employees postretirement or
postemployment benefits. Therefore, the Company is not impacted by the Statement
of Financial Accounting Standards No. 106 "Employers' Accounting for
Postretirement Benefits other than Pensions" or No. 112 "Employers' Accounting
for Postemployment Benefits."

15. CONCENTRATION OF CREDIT RISK

Financial instruments which potentially subject the Company to
concentrations of credit risk consist principally of temporary cash investments
and trade receivables. The Company's temporary cash investments consist
primarily of cash and money market funds. Concentration of credit risk with
respect to trade receivables exists due to the Company's dependence on a few
customers. However, the Company has not sustained any losses related to these
customers.

16. GEOGRAPHIC FINANCIAL INFORMATION

Geographic information regarding the Company's operations for the years
ended December 31, 1997, 1996 and 1995 is shown below. Sales to customers
represent total net sales from the respective geographic area after elimination
of intercompany transactions which were not material. Operating (loss) income is
net revenues less operating costs after elimination of intercompany transactions
which were not material. Identifiable assets are those assets used in the
geographic area and are reflected after the elimination of intercompany
balances.

<TABLE>
<CAPTION>
1997 1996 1995
---- ---- ----
<S> <C> <C> <C>
Sales to Customers
North America .......... $ 11,693,692 $ 4,950,652 $ 3,613,769
Europe ................. 41,216 -- --
------------ ------------ ------------
$ 11,734,908 $ 4,950,652 $ 3,613,769
============ ============ ============
Operating Income (Loss)
North America .......... $ 16,128,720 $ 2,233,099 $ (721,263)
Europe ................. (907,905) (22,064) (199,201)
------------ ------------ ------------
$ 15,220,815 $ 2,211,035 $ (920,464)
============ ============ ============
Identifiable Assets
North America .......... $ 43,648,263 $ 25,971,725 $ 17,346,899
Europe ................. 576,384 22,302 34,677
------------ ------------ ------------
$ 44,224,647 $ 25,994,027 $ 17,381,576
============ ============ ============
</TABLE>

The Company had foreign export sales for the years ended December 31,
1997, 1996 and 1995 of $4,109,054, $1,653,337, and $742,032, respectively.

F-18
<PAGE> 43
BIOMATRIX, INC. AND SUBSIDIARIES

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS - (CONTINUED)

17. MAJOR CUSTOMER AND LICENSE FEE DATA

A significant portion of the Company's products are sold to customers
under the terms of multiple-year marketing and distribution agreements. In many
cases, a customer has paid license fees to the Company for the exclusive rights
in the respective territory. Of the reported product sales for the years ended
December 31, 1997, 1996 and 1995, four customers accounted for 84% (Customer A
20%, Customer C 10%, Customer D 40%, and Customer E 14%), three customers
accounted for 90% (Customer A 40%, Customer B 25% and Customer C 25%), and two
customers accounted for 68% (Customer A 48% and Customer B 20%), respectively.
Of the reported income from licenses, royalties, research contracts, and grants
for the years ended December 31, 1997, 1996 and 1995, two corporate partners
accounted for 96% (Partner E 82% and Partner F 14%), three corporate partners
accounted for 81% (Partner C 49%, Partner B 18% and Partner D 14%) and two
corporate partners accounted for 76% (Partner A 47% and Partner B 29%),
respectively.

18. IMPACT OF THE ADOPTION OF RECENTLY ISSUED ACCOUNTING STANDARDS

In June 1997, the FASB issued Statement of Financial Accounting Standards
No. 130 "Reporting Comprehensive Income" which establishes standards for
reporting and display of comprehensive income and its components in a full set
of financial statements. The Company is required to adopt this standard in 1998
and believes the principal additional component of comprehensive income that
will be required to be disclosed is foreign currency translation.

In June 1997, the FASB issued Statement of Financial Accounting Standards
No. 131 "Disclosures about Segments of an Enterprise and Related Information"
which establishes standards for the way that public enterprises report
information about operating segments, geographic areas, products and major
customers. The Company is required to adopt this standard in 1998 and is
currently evaluating the impact of this standard.

19. SUBSEQUENT EVENTS

In February 1998, the Company entered into a distribution agreement with
Novartis Pharma AG ("Novartis"). The agreement provides Novartis with the
exclusive marketing rights to Synvisc in Central America, South America, and the
Caribbean. In return the Company received an up-front non-refundable payment of
$1,500,000 and will receive an additional $1,600,000 on the earlier of the first
anniversary of commercial launch or December 1999. The Company will manufacture
and supply Synvisc to Novartis for a contractual percentage of Novartis' sales
price. Additionally, Novartis will reimburse the Company for its costs of
maintaining several area business consultants to assist in selling Synvisc in
certain countries.

F-19

<PAGE> 1

BIOMATRIX, INC.

EXHIBIT 21 - LIST OF SUBSIDIARIES

COUNTRY
NAME OF SUBSIDIARY WHERE INCORPORATED
- ------------------ ------------------

Biomatrix Medical Canada Inc. Canada

Biomatrix U.K. Limited Great Britain

Biomatrix Svenska AB Sweden

Biomatrix France SARL France

Biomatrix Schwiez GmbH Switzerland

Biomatrix Hong Kong Limited Hong Kong

<PAGE> 1
EXHIBIT 23.1

CONSENT OF INDEPENDENT ACCOUNTANTS

We consent to the incorporation by reference in the registration statement of
Biomatrix, Inc. on Forms S-8 (File Nos. 33-91066, 33-91064, and 333-29983) and
Form S-3 (File Nos. 33-99856) of our report dated February 23, 1998 on our
audits of the consolidated financial statements of Biomatrix, Inc. as of
December 31, 1997 and 1996, and for the years ended December 31, 1997, 1996,
and 1995, which report is included in this Annual Report on Form 10-K.

/s/ Coopers & Lybrand L.L.P.

Coopers & Lybrand, L.L.P.

Parsipanny, New Jersey
March 26, 1998

<ARTICLE> 5
<CIK> 0000747952
<NAME> BIOMATRIX, INC.
<MULTIPLIER> 1
<CURRENCY> U.S. DOLLARS

<S> <C>
<PERIOD-TYPE> YEAR
<FISCAL-YEAR-END> DEC-31-1997
<PERIOD-START> JAN-01-1997
<PERIOD-END> DEC-31-1997
<EXCHANGE-RATE> 1
<CASH> 17,387,085
<SECURITIES> 0
<RECEIVABLES> 3,517,112
<ALLOWANCES> 25,500
<INVENTORY> 3,111,351
<CURRENT-ASSETS> 25,919,076
<PP&E> 22,011,955
<DEPRECIATION> (4,231,429)
<TOTAL-ASSETS> 44,224,647
<CURRENT-LIABILITIES> 24,016,936
<BONDS> 5,777,465
0
0
<COMMON> 59,814,686
<OTHER-SE> (5,379,534)
<TOTAL-LIABILITY-AND-EQUITY> 44,224,647
<SALES> 11,734,908
<TOTAL-REVENUES> 32,564,256
<CGS> 3,609,907
<TOTAL-COSTS> 17,343,441
<OTHER-EXPENSES> 0
<LOSS-PROVISION> 0
<INTEREST-EXPENSE> 105,696
<INCOME-PRETAX> 16,273,714
<INCOME-TAX> 536,000
<INCOME-CONTINUING> 15,737,714
<DISCONTINUED> 0
<EXTRAORDINARY> 0
<CHANGES> 0
<NET-INCOME> 15,737,714
<EPS-PRIMARY> 1.44
<EPS-DILUTED> 1.39

</TABLE>

<ARTICLE> 5

<S> <C>
<PERIOD-TYPE> 9-MOS
<FISCAL-YEAR-END> DEC-31-1997
<PERIOD-START> JAN-01-1997
<PERIOD-END> SEP-30-1997
<CASH> 21,296,372
<SECURITIES> 1,400,375
<RECEIVABLES> 1,329,778
<ALLOWANCES> 25,500
<INVENTORY> 2,827,096
<CURRENT-ASSETS> 28,448,858
<PP&E> 17,850,898
<DEPRECIATION> (4,046,265)
<TOTAL-ASSETS> 42,530,510
<CURRENT-LIABILITIES> 3,723,055
<BONDS> 5,850,222
0
0
<COMMON> 59,841,776
<OTHER-SE> (4,756,005)
<TOTAL-LIABILITY-AND-EQUITY> 42,530,510
<SALES> 5,504,366
<TOTAL-REVENUES> 24,894,954
<CGS> 1,987,949
<TOTAL-COSTS> 11,595,817
<OTHER-EXPENSES> 73,254
<LOSS-PROVISION> 0
<INTEREST-EXPENSE> 73,254
<INCOME-PRETAX> 13,910,089
<INCOME-TAX> 321,000
<INCOME-CONTINUING> 13,589,089
<DISCONTINUED> 0
<EXTRAORDINARY> 0
<CHANGES> 0
<NET-INCOME> 13,589,089
<EPS-PRIMARY> 1.24
<EPS-DILUTED> 1.21

</TABLE>

<ARTICLE> 5

<S> <C>
<PERIOD-TYPE> 6-MOS
<FISCAL-YEAR-END> DEC-31-1997
<PERIOD-START> JAN-01-1997
<PERIOD-END> JUN-30-1997
<CASH> 14,072,948
<SECURITIES> 3,601,094
<RECEIVABLES> 1,506,209
<ALLOWANCES> 25,500
<INVENTORY> 1,736,367
<CURRENT-ASSETS> 21,981,906
<PP&E> 15,173,558
<DEPRECIATION> (3,881,842)
<TOTAL-ASSETS> 33,550,645
<CURRENT-LIABILITIES> 4,028,608
<BONDS> 5,891,051
0
0
<COMMON> 59,482,537
<OTHER-SE> (3,883,950)
<TOTAL-LIABILITY-AND-EQUITY> 33,550,645
<SALES> 3,743,050
<TOTAL-REVENUES> 11,020,382
<CGS> 1,477,827
<TOTAL-COSTS> 7,583,948
<OTHER-EXPENSES> 27,037
<LOSS-PROVISION> 0
<INTEREST-EXPENSE> 27,037
<INCOME-PRETAX> 3,807,522
<INCOME-TAX> (61,000)
<INCOME-CONTINUING> 3,746,522
<DISCONTINUED> 0
<EXTRAORDINARY> 0
<CHANGES> 0
<NET-INCOME> 3,746,522
<EPS-PRIMARY> 0.35
<EPS-DILUTED> 0.34

</TABLE>

<ARTICLE> 5
<CIK> 0000747952
<NAME> BIOMATRIX, INC.
<MULTIPLIER> 1
<CURRENCY> U.S. DOLLARS

<S> <C>
<PERIOD-TYPE> 3-MOS
<FISCAL-YEAR-END> DEC-31-1997
<PERIOD-START> JAN-01-1997
<PERIOD-END> MAR-31-1997
<EXCHANGE-RATE> 1
<CASH> 7,654,201
<SECURITIES> 7,998,744
<RECEIVABLES> 1,602,445
<ALLOWANCES> (25,500)
<INVENTORY> 860,349
<CURRENT-ASSETS> 19,084,468
<PP&E> 13,546,785
<DEPRECIATION> (3,707,796)
<TOTAL-ASSETS> 29,086,250
<CURRENT-LIABILITIES> 2,734,465
<BONDS> 5,949,740
0
0
<COMMON> 57,082,174
<OTHER-SE> (3,503,851)
<TOTAL-LIABILITY-AND-EQUITY> 29,086,250
<SALES> 1,902,287
<TOTAL-REVENUES> 6,043,131
<CGS> 876,155
<TOTAL-COSTS> 3,665,466
<OTHER-EXPENSES> 27,037
<LOSS-PROVISION> 0
<INTEREST-EXPENSE> 27,037
<INCOME-PRETAX> 2,545,735
<INCOME-TAX> 0
<INCOME-CONTINUING> 2,545,735
<DISCONTINUED> 0
<EXTRAORDINARY> 0
<CHANGES> 0
<NET-INCOME> 2,545,735
<EPS-PRIMARY> 0.24
<EPS-DILUTED> 0.23

</TABLE>

<ARTICLE> 5
<CIK> 0000747952
<NAME> BIOMATRIX, INC.
<MULTIPLIER> 1
<CURRENCY> U.S. DOLLARS

<S> <C>
<PERIOD-TYPE> YEAR
<FISCAL-YEAR-END> DEC-31-1996
<PERIOD-START> JAN-01-1996
<PERIOD-END> DEC-31-1996
<EXCHANGE-RATE> 1
<CASH> 3,034,764
<SECURITIES> 10,603,358
<RECEIVABLES> 1,230,456
<ALLOWANCES> 25,500
<INVENTORY> 727,083
<CURRENT-ASSETS> 16,325,963
<PP&E> 13,088,449
<DEPRECIATION> (3,582,414)
<TOTAL-ASSETS> 25,994,027
<CURRENT-LIABILITIES> 2,491,570
<BONDS> 5,965,930
0
0
<COMMON> 56,683,814
<OTHER-SE> (3,415,531)
<TOTAL-LIABILITY-AND-EQUITY> 25,994,027
<SALES> 4,950,652
<TOTAL-REVENUES> 15,578,912
<CGS> 2,563,060
<TOTAL-COSTS> 13,367,877
<OTHER-EXPENSES> 0
<LOSS-PROVISION> 0
<INTEREST-EXPENSE> 117,465
<INCOME-PRETAX> 2,905,137
<INCOME-TAX> 135,000
<INCOME-CONTINUING> 2,770,137
<DISCONTINUED> 0
<EXTRAORDINARY> 0
<CHANGES> 0
<NET-INCOME> 2,770,137
<EPS-PRIMARY> .27
<EPS-DILUTED> .25

</TABLE>