SYNTHETECH INC
10-K, 2000-06-05
INDUSTRIAL ORGANIC CHEMICALS
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        UNITED STATES SECURITIES AND EXCHANGE COMMISSION

                     Washington, D.C. 20549

                            FORM 10-K

                           (Mark One)
[X]  ANNUAL REPORT PURSUANT TO SECTION 13 or 15(d) OF THE
     SECURITIES EXCHANGE ACT OF 1934
     For the fiscal year ended March 31, 2000

[  ] TRANSITION REPORT PURSUANT TO SECTION 13 or 15(d) OF THE
     SECURITIES EXCHANGE ACT OF 1934
     For the transition period from __________ to __________
Commission file number 0-12992
                        SYNTHETECH, INC.
     (Exact name of registrant as specified in its charter)

                 Oregon                         84-0845771
     (State or other jurisdiction           (I.R.S. Employer
      of incorporation or organization)      Identification No.)
      of incorporation or organization)

     1290 Industrial Way, Albany, Oregon          97321
     (Address  of  principal  executive        (Zip Code)
      offices)

     Registrant's telephone number,            541/967-6575
     including area code:

     Securities registered pursuant to           None
      Section 12(b) of the Act:

     Securities registered pursuant to Section 12(g) of the Exchange Act:

                  Common Stock, $.001 Par Value
                        (Title of class)

Indicate  by check mark whether registrant (1) filed all  reports
required  to  be  filed by Section 13 or 15(d) of the  Securities
Exchange  Act  of  1934 during the past 12 months  (or  for  such
shorter  period  that the registrant was required  to  file  such
reports),  and  (2) has been subject to such filing  requirements
for the past 90 days.   YES  X   NO

Indicate  by  check  mark if disclosure of delinquent  filers  in
response  to  Item 405 of Regulation S-K is not contained  herein
and will not be contained, to the best of registrant's knowledge,
in  definitive  proxy or information statements  incorporated  by
reference in Part III of this Form 10-K or any amendment to  this
Form 10-K.  [   ]

As  of  May  24, 2000, the aggregate market value of  the  voting
stock  held  by nonaffiliates of the registrant was approximately
$34  million based upon $3.25 per share.  Shares of Common  Stock
held by each officer and director and by each person who owns  5%
or  more  of  the Common Stock have been excluded  in  that  such
persons   may  be  deemed  affiliates.   This  determination   of
affiliate  status  is not necessarily a conclusive  determination
for  other  purposes.  The number of the shares of the  Company's
Common   Stock  outstanding  on  May  24,  2000  was  14,276,641.

<PAGE> i

                        Table of Contents
                                                             Page
PART I

Item 1 - Business.......................................       1
Item 2 - Properties.....................................       9
Item 3 - Legal Proceedings..............................      10
Item 4 - Submission of Matters To a Vote of Security
         Holders........................................      11

PART II

Item 5 - Market for Registrant's Common Stock and Related
         Shareholder Matters.............................     11
Item 6 - Selected Financial Data.........................     12
Item 7 - Management's Discussion and Analysis of Financial
         Condition and Results of Operations.............     13
Item 7A- Quantitative and Qualitative Disclosure About
         Market Risk.....................................     19
Item 8 - Financial Statements and Supplementary Data.....     20
Item 9 - Changes In and Disagreements With Accountants
         on Accounting and Financial Disclosure..........     38

PART III

Item 10- Directors and Executive Officers of the Registrant   39
Item 11- Executive Compensation...........................    42
Item 12- Security Ownership of Certain Beneficial Owners
         and Management...................................    48
Item 13- Certain Relationships and Related Transactions...    49

PART IV

Item 14- Exhibits, Financial Statement Schedules and
         Reports on Form 8-K..............................    49

Signatures................................................    52

<PAGE> 1


                             PART I
                             ------
                        ITEM 1.  BUSINESS
                        -----------------
This Annual Report contains forward-looking statements within the
meaning of Section 21E of the Securities Exchange Act of 1934, as
amended.   Actual  results  could differ  materially  from  those
projected  in the forward-looking statements and as a  result  of
the  factors set forth in "Factors Affecting Future Results"  and
elsewhere in this Report.

GENERAL
-------
Synthetech,  Inc.,  an  Oregon  corporation  (the  "Company"   or
"Synthetech"),  produces chemically modified naturally  occurring
and synthetic amino acids which it refers to as "Peptide Building
Blocks"  ("PBBs").   These PBBs are pharmaceutical  intermediates
which  are purchased by major pharmaceutical companies,  emerging
biopharmaceutical companies and contract drug synthesis companies
as   starting   materials   in  the   manufacture   of   peptide,
peptidomimetic  small  molecule and other  drugs.  Using  organic
chemistry  and  biocatalysis  techniques,  the  Company  has  the
expertise and capacity to produce PBBs on a full cycle "grams  to
tons"  production basis for use in all stages of drug development
from   initial   discovery  through  approved,  marketed   drugs.
Synthetech's  PBBs  are  used  in peptide,  peptidomimetic  small
molecule and other drugs under development and on the market  for
the treatment of AIDS, cancer, cardiovascular and other diseases.

MARKET OVERVIEW
---------------
The  market  for  PBBs is driven by the market for  the  peptide,
peptidomimetic small molecule and other drugs in which  they  are
incorporated.   Peptide drugs are chains of  generally  3  to  50
amino  acids and retain their peptide structure after  completion
of drug manufacturing.  Since naturally occurring peptides in the
human  body regulate many  of its  complex  biochemical  systems,
researchers  have been investigating peptide drug  candidates  to
determine  their  ability  to regulate these  systems  to  either
promote   health   or   hinder  disease.  With   structures   and
characteristics similar to the body's own peptides  and  enzymes,
peptide  drugs generally  are quite potent.  Peptide  drugs  also
tend  to  be  administered through intravenous or other  non-oral
delivery  paths.   During clinical trials, PBB orders  for  these
candidates  are  typically multi-kilogram ("multi-kilo") in size.
At  the  marketed drug stage, orders for PBBs for these drugs can
reach the tens of kilograms ("kilos") to hundreds of kilos size.

Researchers  have also been investigating combining one  or  more
amino  acids  with other chemicals which are not amino  acids  to
create  drug  candidates.   These drug  candidates  are  commonly
referred  to  as peptidomimetic small molecule drugs  since  they
exhibit peptide-like qualities in a smaller molecule which is not
a  defined sequence of amino acids. Peptidomimetic small molecule
drugs  typically  are less potent than peptide drugs.  They  also
often  are  able  to  be  administered orally.   During  clinical
trials, PBB orders for these candidates can be in the hundreds of
kilos  to  low tons size. At the marketed drug stage, orders  for
these drugs can reach the tons to tens of tons size.

<PAGE> 2

The  size  of the peptide and peptidomimetic small molecule  drug
market  is  a  function of the number of these  drugs  which  are
initially screened for therapeutic attributes, progress down  the
clinical  trial path toward regulatory approval and,  ultimately,
are  approved  and marketed. The market size for  any  individual
approved  drug  is  affected by many factors, including,  without
limitation,  size  of the patient population addressed,  efficacy
level,  level  and  frequency of side  effects,  method  of  drug
delivery,  cost and competing drugs. The size of the  PBB  market
for  peptide,  peptidomimetic small molecule and other  drugs  is
also a function of the quantities and varieties of PBBs necessary
to  produce  these drugs.  (See "Industry Factors" set  forth  in
Item   7,  Management's  Discussion  and  Analysis  of  Financial
Condition and Results of Operations).

STRATEGY
--------
Synthetech's  strategy  is  to  emphasize  a  commitment  to  its
customers  from  the  early  phases  of  drug  discovery  through
clinical  development in order to develop larger  orders  as  the
drugs receive regulatory approval.

PRODUCT OVERVIEW
----------------
Peptide  Building Blocks.  PBBs are amino acids which  have  been
chemically  modified through organic chemistry  and  biocatalysis
techniques  to  enable  them to link with other  amino  acids  or
chemicals  in  a  particular defined  sequence.  These  PBBs  are
pharmaceutical  intermediates and are used as starting  materials
in  the manufacture of peptide, peptidomimetic small molecule and
other drugs.  The amino acids which are transformed into PBBs may
be  either natural amino acids (that is, amino acids which  occur
in  nature,  including their chiral or "mirror  image"  form)  or
synthetic  amino acids (that is, amino acids which  have  a  side
chain  that does not occur in nature).  Synthetech refers to  the
synthetic amino acids as "Specialty Amino Acids."

Since  1987,  the  Company has produced a wide range  of  natural
amino  acid  PBB  products.  The Company has also  developed  and
manufactures over three dozen Specialty Amino Acids.  The Company
uses  a  wide  array  of raw materials to  produce  PBBs.   These
materials   generally  are  in  adequate  supply  from   multiple
suppliers.

The  Company  has developed and scaled up process  technology  to
produce  this  wide range of PBB products in a  "grams  to  tons"
scale.  The Company continues to produce most bulk orders  on  an
as-ordered  basis.   The Company also maintains  small  inventory
quantities of many PBBs, permitting immediate deliveries.

At  March  31,  2000,  the dollar amount of  backlog  orders  was
$2.42  million, all of which the Company expects to  ship  during
fiscal  2001.  At  March 31, 1999, the dollar amount  of  backlog
orders  was  $8.86 million, including $2.99  million attributable
to the final shipments under a discontinued  large-scale order.

In  January  1990, the Company entered into supply and technology
agreements   with   Biomeasure  Incorporated,   a   Boston   area
biotechnology  company and a subsidiary of Groupe  Pharmaceutique
Beaufour-Ipsen of France with several Specialty Amino Acids under
development.  Under the supply agreement, the Company has  agreed
to  supply  all  of  Biomeasure's requirements for  a  particular
Specialty Amino Acid.  This agreement continues from year to year
unless  terminated in writing by one of the parties.  The Company
and  Biomeasure  are also parties to a license  agreement  giving

<PAGE> 3

Biomeasure the option to receive a license to produce for its own
use the Specialty Amino Acids which are the subject of the supply
agreement  between  the  parties. Under this  license  agreement,
Biomeasure  must pay certain royalty amounts based on any  amount
it produces.

MARKETING
---------
The   Company  markets  its  products  and  capabilities  through
attendance at trade shows, listings in biotechnology and chemical
industry   directories,   advertisements   in   chemical    trade
periodicals and an internet presence.   In addition, the  Company
maintains  ongoing direct relationships with major pharmaceutical
firms,  emerging biopharmaceutical firms, contract drug synthesis
firms and other firms which it believes might have a need for its
products.   The Company typically sells its products directly  to
its  customers, although it uses sales representatives  for  some
European  sales and has often sold products to Japanese customers
through chemical trading firms.

CUSTOMERS
---------
Although  the Company has several hundred customers in more  than
25  countries,  the  Company expects that a  few  customers  will
continue  to  account for a significant portion of revenues  each
year.   During fiscal 2000, the top 20 customers represented  95%
of  the  Company's revenues.  Of these twenty customers, 12  were
major pharmaceutical companies, 4 were emerging biopharmaceutical
companies  and  4  were contract drug synthesis  companies.   The
Company  had  three customers each accounting  for  over  10%  of
fiscal  2000  revenue-F. Hoffman-La Roche, Ltd.,  UCB-Bioproducts
S.A.  and  Searle, which individually accounted for approximately
29%,  19%  and  14%, respectively, of the Company's  fiscal  2000
revenues.

For  the fiscal years ended March 31, 2000, 1999 and 1998,  sales
to international customers were $6.39 million, $6.45 million, and
$2.85  million,  respectively, accounting for approximately  53%,
28%,  and 34%, of the Company's total revenues.  These sales were
principally  to Europe and Mexico for fiscal 2000 and  to  Europe
for fiscal 1999 and 1998.  See Note J to Financial Statements.

COMPETITION
-----------
Because  peptide  and  peptidomimetic small  molecule  drugs  are
relatively  new, the market in the past for PBBs has  been  quite
small -- with sales typically in the hundreds of kilos or smaller
size.   As  a  result,  the  PBB  market  has  not  attracted   a
significant  amount  of  direct  competition.   As   the   market
continues   to  grow  with  larger  order  sizes  becoming   more
prevalent, the Company has begun to see more competition.

Current  competition in multi-kilo quantities  of  natural  amino
acid  based  PBBs  comes  primarily from  several  European  fine
chemical companies.  Multi-ton order sizes of these natural  PBBs
have  begun  to  attract a wider group of approximately  a  dozen
domestic  and international chemical companies.  In the  area  of
Specialty Amino Acids, the Company has competition on a  selected
product basis at the multi-kilo scale from approximately  half  a
dozen  fine  chemical producers in Europe, Japan and  the  United
States.  Competition from companies in developing countries, such
as   India,  China  and  Korea,  is  also  starting  to   emerge.

<PAGE> 4

Competition   also  increases  for  supplying   PBBs   for   drug
development  programs that reach late clinical  trials  and  move
into  approved  status  as a result of the  increased  quantities
typically  required  at  these stages and pharmaceutical  company
requirements to have second sources of material available.   Many
of  the  Company's competitors have technical, financial, selling
and  other  resources available to them which  are  significantly
greater than those available to the Company.

The  principal methods of competition in the market for PBBs  and
other   fine  chemicals  are  quality,  delivery  responsiveness,
customer  service  and  price.   The  Company  believes  that  it
competes  effectively in each of these areas.  The  Company  also
believes  that  its production of a wide range  of  products  and
quantities  gives it a competitive advantage in the  marketplace.
In  addition, the Company believes that pharmaceutical  companies
generally view internal production of PBBs as a misallocation  of
resources  and,  given a reliable source of  a  quality  product,
would rather obtain them from an outside supplier.

RESEARCH AND DEVELOPMENT
------------------------
The Company's Research and Development Group is composed of seven
people,  of which three have graduate degrees in chemistry.   The
Company's  research  and  development efforts  focus  on  process
development  to  support the Company's  PBB  product  lines.   In
addition, the Group explores alternative scaleable routes for PBB
production, especially for its Specialty Amino Acids.

During the fiscal years ended March 31, 2000, 1999 and 1998,  the
Company's   research  and  development  expenses  were  $436,000,
$338,000 and $215,000, respectively.  These figures, however,  do
not  completely  reflect the Company's research  and  development
activity since substantial process development efforts have  been
associated with initial orders for new products and, accordingly,
have  been expensed as cost of sales associated with the  product
revenue  rather than as a research and development expense.   The
Company  estimates  that  its combined research  and  development
effort  (including effort directly associated with  the  sale  of
product) was approximately $522,000, $450,000 and $419,000 during
the   fiscal  years  ended  March  31,  2000,  1999   and   1998,
respectively.

EMPLOYEES
---------
As of May 24, 2000, the Company employed 51 individuals.

REGULATORY MATTERS
------------------
As   the  Company's  products  are  intermediates  sold  to  drug
manufacturers, the Company has been generally unaffected  by  FDA
regulation  which  is  directed at the drug  manufacturers.   The
Company's  customers  do,  however,  typically  conduct  periodic
reviews  and  audits of the Company's operations,  including  its
inspection  and  quality  assurance  programs.   These   programs
involve   materials   tracking,   record   keeping   and    other
documentation.  As  some  customers have  begun  to  request  the
Company   to   manufacture  and  supply  PBBs   with   additional
processing, the Company expects these programs will often include
more  extensive documentation.  The Company anticipates that  the
expenses  of  implementing these programs will  increase  in  the
future.

<PAGE> 5

The  Company's business is also subject to substantial regulation
in the areas of safety, environmental control and hazardous waste
management.  Although  the  Company  believes  that  it   is   in
compliance with these laws, rules and regulations in all material
respects,   the  failure  to  comply  with  present   or   future
regulations  could result in fines being imposed on the  Company,
suspension   of   production  or  cessation  of  operations.   As
additional  and  more extensive regulations are  being  added  in
these  areas  at  the  federal,  state  and  local  levels,   the
compliance  costs  will  inevitably continue  to  increase.   The
operation  of  fine  chemical manufacturing  plants  entails  the
inherent risk of environmental damage or personal injury  due  to
the handling of potentially harmful substances, and there can  be
no  assurance  that material costs and liabilities  will  not  be
incurred  in  the future because of an accident  or  other  event
resulting in personal injury or an unauthorized release  of  such
substances  to  the  environment.  Also,  the  Company  generates
hazardous and other wastes which are disposed of at various  off-
site  facilities.  The  Company may be  liable,  irrespective  of
fault,  for material cleanup costs or other liabilities  incurred
at  these  disposal facilities due to releases of such substances
into the environment.

In  fiscal  2000,  the  Company  undertook  capital  expenditures
aggregating $1.03 million associated with air quality  scrubbers,
waste  water handling and other environmental control facilities.
The   Company   is   currently   reviewing   additional   capital
expenditures associated with environmental control facilities and
has not determined its fiscal 2001 budget.

The   Company  maintains  property  damage  insurance,  liability
insurance,  environmental risk insurance, and  product  liability
insurance.

PRODUCT LIABILITY
-----------------
Use   of  the  Company's  products  in  pharmaceuticals  and  the
subsequent  testing,  marketing and sale of such  pharmaceuticals
involves an inherent risk of product liability.  There can be  no
assurance that claims for product liability will not be  asserted
against  the  Company  or  that the  Company  would  be  able  to
successfully  defend any claim that may be asserted.   A  product
liability  claim  could  have a material adverse  effect  on  the
business and/or financial condition of the Company.  The  Company
maintains  product liability insurance with a $1  million  limit.
Also,  the  Company  maintains  an umbrella  liability  insurance
policy with an additional $9 million of coverage.

COMPANY BACKGROUND
------------------
The  Company was formed in 1981 to develop novel chemical process
technology by combining classical organic chemistry with  enzyme-
based  biocatalysis.  For the first several  years,  it  operated
mainly  as  a research and development group focused  on  process
development  of pharmaceuticals and other fine chemicals.   After
its  initial  public  offering in 1984,  the  Company's  research
efforts  were  concentrated on the development of  a  proprietary
process for aspartame and L-phenylalanine.   Although the Company
has  entered  into one license for this technology,  the  Company
discontinued  marketing this technology  in  1991  and  does  not
expect additional licensing revenue.

Throughout  its  development during the 1980s, the  Company  also
offered contract research services.  These research services were
typically   provided  to  pharmaceutical  clients  and  generally
involved  the  development of biocatalytic  processes  (that  is,
chemical  processes which are affected by the use of  enzymes  or

<PAGE> 6

micro-organisms).  Since the end of fiscal 1990, the Company  has
phased  out  contract research services and does  not  anticipate
receiving any significant revenue from research services  in  the
future.  By the end of the 1980s, the Company, building on  prior
experience,  began to focus on the production of PBBs  and  other
fine chemicals for customers.  With the successful completion  of
two   large-scale  orders,  the  Company  has  demonstrated   its
capability as a full-cycle "grams to tons" PBB producer.

FACTORS AFFECTING FUTURE RESULTS
--------------------------------
This   Annual   Report  on  Form  10-K  includes  forward-looking
statements (as defined in Section 21E of the Securities  Exchange
Act  of  1934, as amended).  Forward-looking statements  include,
without  limitation,  any statement that may  predict,  forecast,
indicate  or  imply future results, performance or  achievements,
and  may  contain  the  words "believe," "anticipate,"  "expect,"
"estimate,"  "project," "will be," "will continue," "will  likely
result"  or  words or phrases of similar meanings. Investors  are
cautioned  that  forward-looking  statements  involve  risks  and
uncertainties and various factors could cause actual  results  to
differ  materially  from the forward-looking  statements.   These
risks  and  uncertainties include, but are not  limited  to,  the
following:

     Uncertain  Market for Products; Customer Concentration;  and
Potential  Quarterly  Revenue  Fluctuations.   Historically,  the
Company  has experienced from time to time substantial period-to-
period  revenue fluctuations reflecting the industry  environment
in which the Company has operated.  The market for PBBs is driven
by   the  market  for  the  synthetically  manufactured  peptide,
peptidomimetic small molecule and other drugs into which they are
incorporated.   The drug development process is dictated  by  the
marketplace, drug companies and the regulatory environment.   The
Company  has  no control over the pace of peptide, peptidomimetic
small  molecule  and  other  drug development,  which  drugs  get
selected  for  clinical trials, which drugs are approved  by  the
Food and Drug Administration ("FDA"), and, even if approved,  the
ultimate potential of such drugs.

     Recurring  sales  of PBBs for discovery  or  clinical  trial
stage  development  programs  is  sporadic  at  best.   The  high
cancellation  rate  for drug development programs  results  in  a
significant  likelihood  that there  will  be  no  subsequent  or
"follow-on"   PBB  sales  for  any  particular  drug  development
program.   Accordingly, the level of purchasing by the  Company's
customers   for   specific  drug  development   programs   varies
substantially  from year to year and the Company cannot  rely  on
any one customer as a constant source of revenue.

     Sales of PBBs for marketed drugs provide an opportunity  for
continuing  longer-term sales and the size of the PBB orders  for
marketed  drugs can be substantially larger than  those  for  the
discovery  or  clinical trial stages.  While not subject  to  the
same high cancellation rate faced by discovery and clinical trial
stage  drug  development programs, the demand  for  the  approved
drugs  remains subject to many uncertainties, including,  without
limitation,  the  drug  price, the  drug  side  effects  and  the
existence  of  other competing drugs.  These factors,  which  are
outside  of the control of the Company, will affect the level  of
demand for the drug itself and, therefore, the demand for PBBs.

<PAGE> 7

     Since  the Company's revenues are composed of PBB  sales  in
all  three drug development stages, and since even sales of  PBBs
for  marketed drugs are subject to cancellation or reduction, the
Company   is   likely  to  continue  to  experience   significant
fluctuations in its quarterly results.

     Industry Cost Factors.  The market for PBBs is dependent  on
the  market for pharmaceutical products.  The levels of  revenues
and profitability of pharmaceutical companies may be affected  by
the continuing efforts of governmental and third party payors  to
contain or reduce the cost of health care through various  means.
For example, in certain foreign markets, pricing or profitability
of prescription pharmaceuticals is subject to government control.
In  the  United States, there have been, and the Company  expects
that  there  will continue to be, a number of federal  and  state
proposals to implement similar government controls.  In addition,
in  both  the  United States and elsewhere, sales of prescription
pharmaceuticals  are  dependent in part on  the  availability  of
reimbursement  to the consumer from third party  payors  such  as
government  and private insurance plans.  Third party payors  are
increasingly challenging the prices charged for medical  products
and  services.   Peptide and peptidomimetic small molecule  drugs
may  not be considered cost effective, and reimbursement may  not
be  available or sufficient to allow these drugs to be sold on  a
profitable  basis.   In  addition,  as  cost  pressures  in   the
pharmaceutical industry have tightened, the cancellation rate for
drug development programs has increased.  Industry cost pressures
can   also   cause   pharmaceutical  companies   to   investigate
alternative  drug manufacturing processes which may  not  include
PBBs.

     Competition.   In  the  past, the  Company  has  not  had  a
significant  amount  of  direct  competition  for  discovery  and
clinical  trial  stage  drug development projects.   The  Company
believes that this resulted from peptide and peptidomimetic small
molecule drugs, particularly those which utilize synthetic  amino
acids,  being  relatively new and the market for PBBs  relatively
small.  As the market has continued to grow with multi-ton  order
sizes becoming more prevalent, the Company has begun to see  more
competition.   Current competition in the multi-kilo  or  smaller
quantities of natural amino acid based PBBs comes primarily  from
several European fine chemical companies.  Multi-ton order  sizes
of  these  natural PBBs have begun to attract a  wider  group  of
domestic  and international chemical companies.  In the  area  of
synthetic amino acid based PBBs, the Company has competition on a
selective  product basis from fine chemical producers  in  Europe
and  Japan.   Competition from companies in developing countries,
such as India, China and Korea, is also starting to emerge.

     Competition has also increased for supplying PBBs  for  drug
development  programs that reach late clinical  trials  and  move
into  an  approved  status  as a result of  increased  quantities
typically  required  at  these stages and pharmaceutical  company
requirements  to have second sources of material available.   The
Company's  competitors  have technical,  financial,  selling  and
other  resources available to them that are significantly greater
than those available to the Company.

     Regulatory Matters.  The Company is subject to a variety  of
federal,  state and local laws, rules and regulations related  to
the  discharge or disposal of toxic, volatile or other  hazardous
chemicals.   Although  the  Company  believes  that  it   is   in
compliance with these laws, rules and regulations in all material
respects,   the  failure  to  comply  with  present   or   future
regulations  could result in fines being imposed on the  Company,
suspension  of  production  or cessation  of  operations.   Third
parties  may  also  have the right to sue to enforce  compliance.
Moreover,  it  is possible that increasingly strict  requirements
imposed by environmental laws and enforcement policies thereunder

<PAGE> 8

could   require   the   Company  to  make   significant   capital
expenditures.   The  operation of a chemical manufacturing  plant
entails  the  inherent risk of environmental damage  or  personal
injury due to the handling of potentially harmful substances, and
there  can  be  no assurance that material costs and  liabilities
will  not  be  incurred in the future because of an  accident  or
other  event resulting in personal injury or unauthorized release
of  such substances to the environment.  In addition, the Company
generates hazardous materials and other wastes which are disposed
at  various  offsite  facilities.  The  Company  may  be  liable,
irrespective  of  fault,  for material  cleanup  costs  or  other
liabilities incurred at these disposal facilities in the event of
a  release  of hazardous substances by such facilities  into  the
environment.    The  Company  has  obtained  environmental   risk
insurance.

     Potential Regulation.  The PBBs produced by the Company  are
intermediate  ingredients  which  are  then  processed   by   the
companies to which they are sold, and are therefore currently not
subject  to the requirements of the FDA. The Company's  customers
do, however, typically conduct periodic reviews and audits of the
Company's  operations,  including  its  inspection  and   quality
assurance  programs.  These programs involve materials  tracking,
record  keeping and other documentation.  As some customers  have
begun to request the Company to manufacture and supply PBBs  with
additional  processing, the Company believes that these  programs
will   often  become  more extensive.  Accordingly,  the  Company
expects  its  compliance documentation efforts will  continue  to
increase  and anticipates that the expenses of implementing  such
programs  will increase in the future.  It is also possible  that
in the future that the Company may not be able to comply with the
applicable  documentation  or  such  documentation  may   require
substantial incremental expense for additional labor and capital.

     Product  Liability.   Use  of  the  Company's  products   in
pharmaceuticals and the subsequent testing, marketing and sale of
such   pharmaceuticals  involves  an  inherent  risk  of  product
liability.   Claims  for  product  liability  could  be  asserted
against  the  Company  and  the  Company  may  not  be  able   to
successfully  defend any claim that may be asserted.   A  product
liability  claim  could  have a material adverse  effect  on  the
business and/or financial condition of the Company.  The  Company
has  purchased  product  liability  insurance  with  a  limit  of
$1  million.   Also, the Company maintains an umbrella  liability
insurance policy with an additional $9 million of coverage.

     Risks of Technological Change.  The market for the Company's
products  is  characterized by rapid changes in both product  and
process technologies.  The Company's future results of operations
will  depend upon its ability to improve and market its  existing
products and to successfully develop, manufacture and market  new
products.  The Company may not be able to continue to improve and
market  its existing products or develop and market new products,
and technological developments could cause the Company's products
and technology to become obsolete or noncompetitive.

     Manufacturing  Capacity.   As a manufacturer  of  PBBs,  the
Company  will  continually face risks regarding the  availability
and  costs  of  raw materials and labor, the potential  need  for
additional capital equipment, increased maintenance costs,  plant
and  equipment obsolescence and quality control. The Company  has
constructed  additional manufacturing and related  facilities  on
its site in Albany, Oregon. Nevertheless, existing facilities may
not  have sufficient capacity to meet the future demand  for  the
Company's  products. A disruption in the Company's production  or
distribution  could  have  a  material  adverse  effect  on   the
Company's  financial results.  Conversely, the  Company  may  not

<PAGE> 9

have  sufficient demand to utilize the additional capacity, which
could  also  have  a  material adverse effect  on  the  Company's
financial results.

     Risks of International Business.  Sales to customers outside
the   United  States  accounted  for  approximately  53%  of  the
Company's net sales during the fiscal year ended March 31,  2000.
The  Company  expects that international sales will  continue  to
account for a significant percentage of net sales.  The Company's
business is and will be subject to the risks generally associated
with  doing business internationally, including changes in demand
resulting   from   fluctuations  in   exchange   rates,   foreign
governmental regulation and changes in economic conditions. These
factors,  among others, could influence the Company's ability  to
sell  its  products in international markets.  In  addition,  the
Company's sale of its products is subject to the risks associated
with  legislation  and regulation relating to imports,  including
quotas,  duties  or  taxes  and other charges,  restrictions  and
retaliatory actions on imports into other countries in which  the
Company's  products may be sold.  The Company is also subject  to
similar  risks  with respect to the importation of raw  materials
from foreign countries.





                       ITEM 2.  PROPERTIES
                       -------------------

Synthetech's headquarters and production facility are located in
Albany, Oregon.  The Company purchased this Albany, Oregon
property in 1987.  Since then, it has undergone a number of plant
and building expansions on site.  At present, the Company's
facilities, which aggregate 47,700 square feet, include
production, pilot plant, laboratory, warehouse and office space.
These facilities include a recently constructed separate 20,000
square foot production facility with six production bays.  Three
of these bays have been outfitted with reactor vessels and other
equipment and are operational.  A fourth bay is being outfitted
with reactor vessels and other equipment and can be completed and
put into service as the Company needs additional capacity.  The
final two bays remain vacant and available for future expansion.

To  accomplish  the plant expansions, Synthetech  has  contracted
with  various  third party providers.  The Company typically  has
issued   purchase   orders  to  such  providers   with   detailed
specifications,  services to be provided and  the  prices  to  be
paid.   The  Company has received either limited  or  no  written
warranties by such third party providers and, therefore,  may  be
limited  in its ability to pursue remedies in the event that  the
new  building  has  problems  or other  defects  in  the  future.
However, the building has been inspected by the City of Albany to
verify  that,  as  constructed, it meets all applicable  building
codes,  including  ADA, electrical, seismic, fire  and  hazardous
occupancy.   All  specifications were reviewed by an  independent
third-party engineering firm selected by the City of Albany prior
to approval of various construction permits.

<PAGE> 10

                   ITEM 3.  LEGAL PROCEEDINGS
                   --------------------------
Not applicable.

<PAGE> 11

  ITEM 4.  SUBMISSION OF MATTERS TO A VOTE OF SECURITY HOLDERS
  ------------------------------------------------------------
Not applicable.



                             PART II
                             -------
        ITEM 5.  MARKET FOR REGISTRANT'S COMMON STOCK AND
        -------------------------------------------------
                  RELATED SHAREHOLDER MATTERS
                  ---------------------------
The  Company's Common Stock trades on the Nasdaq National Market.
The  Company's  common  stock  trading  symbol  is  "NZYM."   The
following table sets forth the range of high and low sales prices
for the Common Stock for the last two fiscal years as reported by
Nasdaq.

<TABLE>
<CAPTION>
<S>                     <C>        <C>         <C>         <C>
                                Fiscal Year Ended March 31,
                                --------------------------
                               2000                   1999
                               ----                   ----
                         High        Low         High        Low
                         ----        ---         ----        ---
     First Quarter      $6.41       $4.00       $8.00       $6.00

     Second Quarter      6.38        4.25        7.00        3.38

     Third Quarter       4.63        3.25        7.13        3.88

     Fourth Quarter      6.88        3.44        6.50        4.00

</TABLE>
___________________________


No  dividends on the Company's Common Stock have been paid  since
inception and the Company does not anticipate that dividends will
be  paid in the foreseeable future.  The number of record holders
of Common Stock as of May 24, 2000 was 589.

<PAGE> 12

                ITEM 6.  SELECTED FINANCIAL DATA
                --------------------------------
The  following  selected financial data  were  derived  from  the
Company's  financial statements audited by Arthur  Andersen  LLP.
The  following data should be read in conjunction with  "Item  8.
Financial  Statements  And  Supplementary  Data"  and  "Item   7.
Management's  Discussion and Analysis of Financial Condition  and
Results of Operations" included elsewhere herein.

<TABLE>
<CAPTION>
<S>                          <C>       <C>     <C>       <C>     <C>
                                        Year Ended March 31,
                              2000      1999     1998    1997     1996
                              ----      ----     ----    ----     ----
                               (in thousands, except per share data)

 STATEMENTS OF INCOME DATA:
 Revenues                    $12,132  $ 23,133  $ 8,321  $12,797  $ 8,472

 Gross Profit                  4,196    10,150    3,001    7,694    4,787
 Operating Income              2,544     8,341    1,611    6,248    3,737

 Net Income                  $ 1,942   $ 5,418  $ 1,221  $ 4,112  $ 2,574

 Basic Earnings Per Share      $0.14     $0.38    $0.09    $0.30    $0.21
 Diluted Earnings Per          $0.14     $0.38    $0.09    $0.29    $0.19


                                               March 31,

                                2000     1999      1998     1997     1996
                                ----     ----      ----     ----     ----
                                              (in thousands)

 BALANCE SHEET DATA:
 Working Capital              $12,300  $12,110  $ 8,237  $ 9,242  $ 8,157

 Total Assets                  26,917   26,230   19,364   17,323   10,959
 Long-Term Debt                   135      152      166      180        -
 Retained Earnings             16,291   14,349    8,931    7,710    3,598
 Shareholders' Equity         $25,058  $23,027  $17,306  $15,797  $10,100

</TABLE>

<PAGE> 13


        ITEM 7.  MANAGEMENT'S DISCUSSION AND ANALYSIS OF
        ------------------------------------------------
          FINANCIAL CONDITION AND RESULTS OF OPERATIONS
          ---------------------------------------------
OVERVIEW
--------
Synthetech's large-scale production during fiscal 2000 and fiscal
1999  confirmed the Company's capability to produce PBBs  at  the
higher  volumes  often associated with marketed  drugs.  Combined
with the Company's already well established production capability
at  the  research  and clinical testing stages, the  Company  has
demonstrated a full cycle "grams to tons" production  capability.
This  full  cycle  capability reinforces  Synthetech's  long-term
growth  strategy emphasizing a commitment to its  customers  from
the  early  phases of discovery through clinical development  and
culminating in marketed drugs.

Despite  the drop in revenues for fiscal 2000 compared to  fiscal
1999,  the  Company remains profitable and in a  sound  financial
condition.  The Company's operating cash flow during fiscal  2000
and   financial  reserves  enabled  it  to  continue  significant
investments  in  facilities  and  organizational  infrastructure.
While the financial results for the first half of fiscal 2001 may
be  similar to the second half of fiscal 2000, Synthetech remains
well  positioned for growth and active as a supplier  of  Peptide
Building  Blocks  (PBBs)  for several pharmaceutical  development
projects in clinical trials.  Although the progress and timing of
these projects remain outside the Company's control, there are  a
number  of different combinations with the potential to  generate
substantial future revenues.

OPERATIONS
----------
The  following  table sets forth, for the periods indicated,  the
percentage of revenues represented by each item included  in  the
Statements of Income.

<TABLE>
<CAPTION>
<S>                          <C>        <C>        <C>
                                  Percentage of Revenues
                               Fiscal Year Ended March 31,
                               ---------------------------
                                  2000      1999      1998
                                  ----      ----      ----
        Revenues                 100.0%    100.0%    100.0%
        Cost of Revenues          65.4%     56.1%     63.9%
                                 ------    ------    ------
        Gross Profit              34.6%     43.9%     36.1%

        Research and
         development               3.6%      1.5%      2.6%
        Selling, general
         and administrative       10.0%      6.4%     14.1%
                                  -----     -----     -----
        Operating Income          21.0%     36.0%     19.4%

        Other Income               2.9%      0.9%      3.7%
        Interest Expense          (0.1)%    (0.1)%       -
                                  ------    ------    -----
        Income Before Income
         Taxes                    23.8%      36.8%     23.1%

        Provision for Income
         Taxes                     7.8%      13.5%      8.4%
                                  -----      -----     -----
        Net Income                16.0%      23.3%     14.7%
                                  =====      =====     =====
<PAGE> 14

Revenues
---------
Synthetech  revenues  were  $12.13 million,  $23.13  million  and
$8.32  million  in  fiscal 2000, fiscal  1999  and  fiscal  1998,
respectively,  reflecting the unpredictability and potential  for
significant  revenue fluctuations associated  with  the  industry
environment  in  which the Company operates.  Revenues  decreased
48%  in  fiscal  2000  as compared to fiscal  1999  and  revenues
increased  178%  in  fiscal  1999 as  compared  to  fiscal  1998.
Synthetech's revenue decrease in fiscal 2000 compared  to  fiscal
1999  and revenue increase in fiscal 1999 compared to fiscal 1998
were largely due to absence or presence of large-scale orders.

Revenues    from   large-scale   orders   were   $3.2    million,
$14.14 million and $2.17 million for fiscal 2000, fiscal 1999 and
fiscal  1998,  respectively.  The $3.2 million large-scale  order
revenue  in fiscal 2000 was attributable to the completion  of  a
large-scale  PBB order for a marketed drug initially received  in
fiscal 1998.  This order provided $10.18 million and $879,000  of
revenue  in  fiscal 1999 and 1998, respectively. One other  large
scale  order  for  a  marketed drug provided  $3.96  million  and
$1.29 million of revenue in fiscal 1999 and 1998, respectively.

The  Company estimates that in fiscal 2000 approximately  31%  of
the  Company's  PBB sales went into marketed drugs, approximately
65%  went into drugs in clinical trials and approximately 4% went
into  drugs  at  the R&D or discovery stage. In fiscal  1999  and
fiscal  1998,  the Company estimates that approximately  63%  and
46%,  respectively, of the Company's PBB sales went into marketed
drugs,  approximately 33% and 41%, respectively, went into  drugs
in  clinical  trials and approximately 4% and 13%,  respectively,
went  into  drugs at the R&D or discovery stage. These  estimates
are  based  on  an  analysis  of the  Company's  sales,  publicly
available  information and information to  the  extent  available
from customers.

The   level  of  Synthetech's  business  from  period  to  period
continues  to  be unpredictable to a large extent.  Although  PBB
sales associated with marketed drugs are more likely to provide a
longer  term,  ongoing revenue stream than sales associated  with
drugs  at  the  clinical  or discovery  stages,  continuation  of
customer  demand for PBBs associated with marketed drugs  remains
subject   to   various  market  conditions,  including,   without
limitation, potential use of alternative manufacturing routes and
continued  market demand for the drug and competition from  other
suppliers of PBBs. For example, the customer to whom the  Company
shipped  $3.2  million  in  fiscal 2000  PBB  orders  adopted  an
alternative lower-cost manufacturing route not using Synthetech's
PBB  and  the Company does not expect any additional  orders  for
this  product from this customer. Accordingly, while  large-scale
orders for marketed drugs can provide significant and predictable
revenues for the duration of the orders, there continues to be  a
significant  risk  that  revenues can fluctuate  from  period  to
period.  The Company is also not expecting additional  orders  in
the  near  term from the other customer which placed large  scale
orders  in  fiscal 1998 and 1999 since certain side effects  have
reduced  the demand for the drug and, therefore, the  demand  for
the Company's PBBs.

The  level of Synthetech's business from period to period at  the
clinical and discovery stages remains unpredictable as well.  For
example, in the third quarter of fiscal 2000 the Company received
a  $3.6 million order for use in a drug in clinical trials.   The
customer's inability to timely source raw materials for the order
and  a  subsequent curtailed and revised scope  of  this  project
resulted in only $712,000 of product being shipped during  fiscal
2000  and the payment to the Company of a $660,000 idle equipment
reservation  charge in the fourth quarter of fiscal 2000.   Under

<PAGE> 15

the revised scope of this project, Synthetech expects to ship  an
additional $2 million for this project to the customer in  fiscal
2001.

With  this industry environment, it is difficult to predict  with
certainty the level of future business. The Company's backlog  of
PBB  orders  at  March  31,  2000 was  $2.42  million  (of  which
$2  million  represents  shipments under  the  project  discussed
above)  compared to a backlog at March 31, 1999 of $8.86 million.
While  the  Company believes that the financial results  for  the
first  half of fiscal 2001 may be similar to the second  half  of
fiscal  2000, it remains active as a supplier of Peptide Building
Blocks (PBBs) for several pharmaceutical development projects  in
clinical  trials.   These projects could have substantial  future
business  potential. There are, however, many  factors  affecting
the   success   of   these  drug  candidates   and   Synthetech's
involvement. (See "Industry Factors" below.)

Gross Profit
------------
Gross  profit was $4.20 million, $10.15 million and $3.00 million
in  fiscal 2000, fiscal 1999 and fiscal 1998, respectively.  This
reflects  a  59.0% decrease in gross profit in fiscal  2000  from
fiscal 1999, and a 238.0% increase in gross profit in fiscal 1999
from  fiscal  1998.  As  a percentage of revenues,  gross  profit
margins  were 34.6%, 43.9% and 36.1% in fiscal 2000, fiscal  1999
and fiscal 1998, respectively.

The  decrease  in  the gross profit margins for  fiscal  2000  as
compared  to fiscal 1999 reflected a combination of factors:  the
downward  pressure caused by a lower level of revenues in  fiscal
2000  and  the increased manufacturing overhead costs  associated
with  the second phase expansion of the new plant in fiscal  2000
being  somewhat  offset  by  the  positive  impact  of  the  idle
equipment  reservation fee.  The increase  in  the  gross  profit
margins for fiscal 1999 as compared to fiscal 1998 resulted  from
the  mix  of products (i.e., type and volume of products sold  as
individual orders) and the fiscal 1999's closely associated  high
revenue levels.  The Company expects revenues and product mix  to
continue  to fluctuate from period to period and cause  variation
in gross profit margins.

Operating Expenses
------------------
Research  and development (R&D) expense increased to $436,000  or
3.6%  of sales, in fiscal 2000, from $338,000, or 1.5% of  sales,
in  fiscal  1999.  R&D expense was $215,000, or 2.6%,  in  fiscal
1998.  The  increase in fiscal 2000 resulted  primarily  from  an
increase in personnel.  These figures, however, do not completely
reflect  the  Company's research and development  activity  since
substantial process development efforts have been associated with
initial  orders  for  new  products and, accordingly,  have  been
expensed  as  cost of sales associated with the  product  revenue
rather  than  as a research and development expense. The  Company
estimates  that  its  combined research  and  development  effort
(including  effort directly associated with the sale of  product)
was  approximately  $522,000, $450,000 and  $419,000  during  the
fiscal years ended March 31, 2000, 1999 and 1998, respectively.

Selling,  general  and administrative (SG&A)  expense  was  $1.22
million,  $1.47 million and $1.18 million in fiscal 2000,  fiscal
1999  and  fiscal  1998, respectively. The decrease  in  SG&A  in
fiscal 2000 from fiscal 1999 primarily reflected a reduced  bonus
pool, reduced compensation expenses related to the granting of  a
non-qualified  stock  option,   and  payments made  pursuant to a

<PAGE> 16

termination of employment in fiscal 1999.  The increase  in  SG&A
in fiscal 1999 from fiscal 1998 primarily reflected the increased
labor  costs  described below and payments  made  pursuant  to  a
termination  of  employment. SG&A as a percentage  of  sales  was
10.0%,  6.4%  and 14.1% for fiscal 2000, fiscal 1999  and  fiscal
1998, respectively.

Operating Income
----------------
Operating income was $2.54 million in fiscal 2000, $8.34  million
in  fiscal 1999 and $1.61 million in fiscal 1998. In fiscal 2000,
Company-wide  labor  costs (including the  employee  bonus  pool)
("labor costs") decreased to $2.36 million from $2.48 million  in
fiscal 1999.  While the salary component of labor costs in fiscal
2000  increased,  it  was  more than offset  by  the  significant
reduction of the bonus pool for fiscal 2000 as compared to fiscal
1999.

In   fiscal   1999,  the  Company's  labor  costs  increased   to
$2.48  million  from $1.50 million in fiscal 1998. Commencing  in
the second half of fiscal 1998 and continuing in fiscal 1999, the
Company  hired additional employees in connection with its  plant
expansion  and  overall  Company growth. The  increase  in  labor
costs  in fiscal 1999 reflected this hiring program. In addition,
the  Company's  fiscal 1999 employee bonus pool was significantly
higher  than the fiscal year 1998 pool, reflecting fiscal  1999's
record results.

As a percentage of revenues, operating income was 21.0% in fiscal
2000, 36.0% in fiscal 1999 and 19.4% in fiscal 1998.

Other Income
------------
The  $361,000 net other income in fiscal 2000 resulted  primarily
from $364,000 of interest earnings less miscellaneous expenses of
$3,000.   The  $215,000 net other income in fiscal 1999  resulted
primarily  from $275,000 of interest earnings less  miscellaneous
expenses of $60,000. The $312,000 net other income in fiscal 1998
primarily  resulted  from  $294,000 of interest  earnings  and  a
$25,000 recognized gain from the sale of securities available for
sale.

Net Income
----------
In  fiscal  2000, the Company earned $2.89 million before  income
taxes.  A provision for income taxes of $949,000 resulted in  net
income  of  $1.94  million.  In fiscal 1999, the  Company  earned
$8.54  million before income taxes. A provision for income  taxes
of  $3.12  million  resulted in net income of $5.42  million.  In
fiscal  1998,  the  Company earned $1.92  million  before  income
taxes.  A provision for income taxes of $702,000 resulted in  net
income  of $1.22 million. The effective tax rates for the Company
were  32.8%,  36.5%  and 36.5% in fiscal 2000,  fiscal  1999  and
fiscal  1998,  respectively.  The decrease in the  effective  tax
rate  for fiscal 2000 from fiscal 1999 reflects a relatively high
proportion  of  export sales in fiscal 2000  and  the  associated
foreign sales corporation tax benefit.

INDUSTRY FACTORS
----------------
The  market  for  PBBs is driven by the market for  synthetically
manufactured  peptide, peptidomimetic small  molecule  and  other
drugs  in  which  they  are incorporated.  The  drug  development
process  for  these  drugs is dictated by the  marketplace,  drug

<PAGE> 17

companies  and  the regulatory environment. The  Company  has  no
control  over  the pace of these drug development efforts,  which
drugs  get selected for clinical trials, which drugs are approved
by  the  FDA and, even if approved, the ultimate market potential
of such drugs.

The three stages of the drug development process include:  R&D or
discovery  stage, clinical trial stage and marketed  drug  stage.
Synthetech's customers can spend years researching and developing
new  drugs, taking only a small percentage to clinical trials and
fewer  yet  to  commercial market. A substantial  amount  of  the
activity continues to occur at the earlier stages of research and
development  and  clinical trials. The  market  for  peptide  and
peptidomimetic  small  molecule drugs  is  still  very  early  in
development.

Recurring  sales of PBBs for development programs is sporadic  at
best.  The  high cancellation rate for drug development  programs
results  in  a  significant likelihood  that  there  will  be  no
subsequent  or  "follow-on" PBB sales  for  any  particular  drug
development program. Accordingly, the level of purchasing by  the
Company's customers for specific drug development programs varies
substantially from quarter to quarter and the Company cannot rely
on any one customer as a constant source of revenue.

The   size  of  the  PBB  orders  for  marketed  drugs   can   be
substantially  larger  than those for the discovery  or  clinical
trial  stages. Sales of PBBs for marketed drugs can also  provide
an  opportunity  for  continuing  longer-term  sales.  While  not
subject to the same high cancellation rate faced by discovery and
clinical  trial stage drug development programs, the  demand  for
the   approved   drugs,   however,  remains   subject   to   many
uncertainties, including, without limitation, the drug price, the
drug  side  effects and the existence of other  competing  drugs.
These  factors, which are outside of the control of the  Company,
will  affect  the  level  of  demand for  the  drug  itself  and,
therefore, the demand for PBBs. Also, industry cost pressures can
cause  pharmaceutical companies to explore and, as was  the  case
with  one of the large-scale orders, ultimately adopt alternative
manufacturing  processes which do not include the Company's  PBBs
as  an  intermediate. Finally, with the longer-term, larger-scale
orders, the Company expects increased competition to supply these
PBBs.

Accordingly, these industry factors create an inability  for  the
Company  to predict future demand beyond its current order  base.
Until  the  Company  develops a stable baseload  of  demand,  the
Company   is   likely  to  continue  to  experience   significant
fluctuations in its quarterly results.

LIQUIDITY AND CAPITAL RESOURCES
-------------------------------
At   March   31,  2000,  the  Company  had  working  capital   of
$12.30 million compared to $12.11 million at March 31, 1999.  The
Company  does not invest in derivative securities.  The Company's
cash   and   cash   equivalents  at  March   31,   2000   totaled
$6.40  million, a $1.07 million decrease from the March 31,  1999
level.  This net decrease reflected a number of factors including
decreased  accounts  receivable, increased  inventory,  decreased
accounts  payable  and increased deferred revenue  together  with
substantial capital expenditures involving the phase two  of  the
plant  expansion and upgrades to the existing plant.  All of  the
Company's $3.75 million capital expenditures in fiscal 2000  were
internally  funded.  In addition, the Company  has  a  $1,000,000
unsecured bank line of credit. As of March 31, 2000 there was  no
amount outstanding under the bank line.

<PAGE> 18

The decrease in accounts receivable to $2.43 million at March 31,
2000,  from $3.41 million at March 31, 1999, reflected the  lower
level  of  revenues in the fourth quarter of fiscal 2000 compared
to  the  fourth quarter in the prior year. The increase of income
tax receivable to $137,000 at March 31, 2000 from $0 at March 31,
1999 and the reduction of accrued income taxes to $0 at March 31,
2000  from  $561,000 at March 31, 1999 reflected overpayments  of
estimated taxes.  The increase in inventories to $4.11 million at
March  31,  2000 from $3.36 million at March 31, 1999 principally
reflected the manufacturing and stocking of certain products  for
future  sale  and,  to a lesser extent, the provisioning  of  raw
materials  for  specific  projects.   The  decrease  in  accounts
payable to $547,000 at March 31, 2000 from $1.54 million at March
31,   1999   primarily  reflected  the  timing   of   expenditure
commitments  related to the second phase of the  plant  expansion
and  timing  of raw material purchases. The decrease  in  accrued
compensation to $109,000 at March 31, 2000 from $375,000 at March
31,   1999   primarily  reflected  accrued  bonus   and   related
compensation  paid  during the first quarter.   The  increase  in
deferred  revenue to $544,000 at March 31, 2000 from  $44,000  at
March 31, 1999 resulted from  customer advance payments.

In fiscal 1998, the Company completed the 20,000 square foot, two-
story  new  building  plant expansion project.  In  this  initial
phase, the Company completed the building structure and built out
two   of  the  six  production  bays.  The  overall  engineering,
construction  and equipment costs for this project  spanning  one
and  one-half years were approximately $8.23 million. The Company
has   undertaken  an  approximately  $6.5  million   second-phase
expansion  outfitting additional bays of the new plant with  four
additional   multipurpose   reactor  systems   and   constructing
additional  warehouse, bulk storage and related facilities.  Most
of   the  second-phase  expansion  has  been  completed  and   is
operational.    During   fiscal  2000,  the   Company's   capital
expenditures were $3.75 million, $3.34 million of which were  for
the  second  phase plant expansion and $410,000 for the  existing
plant  and  equipment upgrades.  During fiscal 2001, the  Company
estimates that roughly $1 million will be used substantially  for
existing  plant  and equipment upgrades and  a  small  amount  to
finish  the second-phase plant expansion.  The Company,  however,
has  not finalized its capital expenditure budget for fiscal 2001
and  will be also reviewing other possible projects.  The Company
expects to finance these capital expenditures internally and does
not anticipate a need for any new debt or equity financing.

The  Company  owns  its facility and all of  its  equipment.  See
Note D to Financial Statements for a description of the Company's
property, plant and equipment.

YEAR 2000
---------
The  Year  2000  ("Y2K") issue arose as the  result  of  existing
computer programs that use only the last two digits to refer to a
year.  Any  of  the Company's computer programs that  have  date-
sensitive  software may recognize a date using "00" as  the  year
1900  rather than the year 2000.  If not corrected, many computer
applications could fail or create erroneous results.

The  Company  established a Y2K team lead by its Chief  Financial
Officer.   During fiscal 2000, the team completed its  assessment
of  the  Company's  information systems  which  support  business
applications  and  the  Company believes that  these  information
system  components are current with all Y2K updates  and  changes

<PAGE> 19

recommended   by  the  vendors.  The  team  also  completed   its
assessment   of   the   Company's   research   and   development,
manufacturing processes and facility management systems  and  the
Company  believes that these systems and components  are  current
with all Y2K updates and changes recommended by the vendors.  The
Company  also completed its survey of key suppliers and customers
to  determine the level of their Y2K readiness. Due to the nature
and  size of its operations and its Y2K efforts, the Company  did
not  develop any contingency plans other than to identify  second
sources  for  any of its key suppliers who could not  advise  the
Company  that they were Y2K compliant. The Company's  information
technology expenditures for fiscal 2000 were $197,000,  of  which
approximately 24% related to the Company's Y2K program, including
$18,000  paid to outside consultants.  These expenses  were  paid
out of revenues from operations.  To date, the Company is unaware
of  any significant Y2K issues affecting it, its key suppliers or
customers.



     ITEM 7A.  QUANTITATIVE AND QUALITATIVE DISCLOSURE ABOUT
     -------------------------------------------------------
                           MARKET RISK
                           -----------
No disclosure is required under this item.

<PAGE> 20

      ITEM 8.  FINANCIAL STATEMENTS AND SUPPLEMENTARY DATA
      ----------------------------------------------------



                      Index                                           Page
                      -----                                           ----
Report of Independent Public Accountants for the years ended
March 31, 2000, 1999 and 1998...............................            21

Financial Statements:

  Balance Sheets as of March 31, 2000 and
  1999......................................................            22

  Statements of Income for the years ended March 31, 2000,
  1999 and 1998.............................................            24

  Statements of Shareholders' Equity and Comprehensive
  Income for the years ended March 31, 2000, 1999 and 1998..            25

  Statements of Cash Flows for the years ended March 31,
  2000, 1999, and 1998......................................            26

Notes to Financial Statements:

  Note A - General and Business.............................            27

  Note B - Summary of Significant Accounting Policies.......            27

  Note C - Inventories......................................            30

  Note D - Property, Plant and Equipment....................            30

  Note E - Income Taxes.....................................            31

  Note F - Line of Credit...................................            31

  Note G - Note Payable.....................................            32

  Note H - Shareholders' Equity.............................            32

  Note I - 401(k) Profit Sharing Plan.......................            35

  Note J - Segment Information..............................            36

  Note K - Commitments and Contingencies....................            36

Supplementary Financial Data................................            37

<PAGE> 21

REPORT OF INDEPENDENT PUBLIC ACCOUNTANTS

To the Board of Directors and Shareholders of Synthetech, Inc.:

We  have  audited the accompanying balance sheets of  Synthetech,
Inc.  (an Oregon corporation) as of March 31, 2000 and 1999,  and
the  related  statements  of  income,  shareholders'  equity  and
comprehensive income, and cash flows for each of the three  years
in  the  period ended March 31, 2000.  These financial statements
are   the  responsibility  of  the  Company's  management.    Our
responsibility  is  to  express an  opinion  on  these  financial
statements based on our audits.

We  conducted  our  audits in accordance with auditing  standards
generally accepted in the United States.  Those standards require
that we plan and perform the audit to obtain reasonable assurance
about  whether  the  financial statements are  free  of  material
misstatement.   An  audit includes examining, on  a  test  basis,
evidence  supporting the amounts and disclosures in the financial
statements.   An  audit  also includes assessing  the  accounting
principles used and significant estimates made by management,  as
well  as evaluating the overall financial statement presentation.
We  believe  that our audits provide a reasonable basis  for  our
opinion.

In  our  opinion,  the  financial statements  referred  to  above
present  fairly, in all material respects, the financial position
of  Synthetech,  Inc.  as of March 31, 2000  and  1999,  and  the
results  of  its operations and its cash flows for  each  of  the
three years in the period ended March 31, 2000 in conformity with
accounting principles generally accepted in the United States.


Arthur Andersen LLP
Portland, Oregon,
May 12, 2000


<PAGE> 22
                                      SYNTHETECH, INC.


                                       BALANCE SHEETS
                                    ----------------------

</TABLE>
<TABLE>
<CAPTION>
<S>                                        <C>                 <C>


At March 31,                                     2000            1999
------------                                    ------          ------

 ASSETS
 ------

CURRENT ASSETS:
  Cash and cash equivalents                   $ 6,404,000     $ 7,470,000
  Accounts receivable, less allowance
    for doubtful accounts of $15,000
    for 2000 and 1999                           2,433,000       3,414,000
  Income tax receivable                           137,000               -
  Inventories                                   4,112,000       3,359,000
  Prepaid expenses                                285,000         284,000
  Deferred income taxes                           140,000         133,000
  Other current assets                             31,000           5,000
                                              -----------     -----------
    TOTAL CURRENT ASSETS                       13,542,000      14,665,000


PROPERTY, PLANT AND EQUIPMENT, at cost, net    13,375,000      11,561,000

OTHER ASSETS                                            -           4,000
                                              -----------     -----------
   TOTAL ASSETS                               $26,917,000     $26,230,000
                                              ===========     ===========
</TABLE>

The accompanying notes are an integral part of these financial statements.

<PAGE> 23


                                      SYNTHETECH, INC.

                                       BALANCE SHEETS
                                  -------------------------
                                         (continued)
<TABLE>
<CAPTION>
<S>                                              <C>            <C>
At March 31,                                     2000            1999
-------------------------------------            ----            ----
 LIABILITIES AND SHAREHOLDERS' EQUITY
-------------------------------------

CURRENT LIABILITIES:
  Current portion of note payable             $    17,000     $    15,000
  Accounts payable                                547,000       1,543,000
  Accrued compensation                            109,000         375,000
  Deferred revenue                                544,000          44,000
  Accrued income taxes                                  -         561,000
  Other accrued liabilities                        25,000          17,000
                                              -----------     -----------
       TOTAL CURRENT LIABILITIES                1,242,000       2,555,000

DEFERRED INCOME TAXES                             482,000         496,000

NOTE PAYABLE, net of current portion              135,000         152,000

SHAREHOLDERS' EQUITY:
  Common stock, $.001 par value; authorized
   100,000,000 shares; issued and outstanding,
   14,277,000 and 14,252,000 shares                14,000          14,000
  Paid-in capital                               8,793,000       8,740,000
  Deferred  compensation                          (40,000)        (76,000)
  Retained earnings                            16,291,000      14,349,000
                                              -----------     -----------
       TOTAL SHAREHOLDERS' EQUITY              25,058,000      23,027,000
                                              -----------     -----------
       TOTAL LIABILITIES AND
        SHAREHOLDERS' EQUITY                  $26,917,000     $26,230,000
                                              ===========     ===========
</TABLE>

The accompanying notes are an integral part of these financial statements.

<PAGE> 24

                                    SYNTHETECH, INC.

                                  STATEMENTS OF INCOME
                              ------------------------------
<TABLE>
<CAPTION>
<S>                             <C>            <C>           <C>

For The Year Ended March 31,       2000           1999            1998
----------------------------    ---------      ----------      ----------

REVENUES                      $12,132,000     $23,133,000       $8,321,000
COST OF REVENUES                7,936,000      12,983,000        5,320,000
                              -----------     -----------       ----------
GROSS PROFIT                    4,196,000      10,150,000        3,001,000
                              -----------     -----------       ----------

  Research and development        436,000         338,000          215,000
  Selling, general and
   administrative               1,216,000       1,471,000        1,175,000
                              -----------     -----------      -----------
OPERATING EXPENSE               1,652,000       1,809,000        1,390,000
                              -----------     -----------      -----------
OPERATING INCOME                2,544,000       8,341,000        1,611,000

OTHER INCOME, net                 361,000         215,000          312,000
INTEREST EXPENSE                  (14,000)        (17,000)               -
                              -----------     -----------      -----------
INCOME BEFORE INCOME TAXES      2,891,000       8,539,000        1,923,000

PROVISION FOR INCOME TAXES        949,000       3,121,000          702,000
                              -----------     -----------      -----------
NET INCOME                    $ 1,942,000     $ 5,418,000      $ 1,221,000
                              ===========     ===========      ===========

BASIC EARNINGS PER SHARE            $0.14           $0.38            $0.09
                                    =====           =====            =====

DILUTED EARNINGS PER SHARE          $0.14           $0.38            $0.09
                                    =====           =====            =====
</TABLE>

The accompanying notes are an integral part of these financial statements.

<PAGE> 25

                                           SYNTHETECH, INC.

                    STATEMENTS OF SHAREHOLDERS' EQUITY AND COMPREHENSIVE INCOME
                    -----------------------------------------------------------
<TABLE>
<CAPTION>
<S>                             <C>        <C>       <C>        <C>            <C>             <C>           <C>

                                                                 EMPLOYEE
                                                                   NOTES
                                    COMMON STOCK                 RECEIVABLE       CUMULATIVE
                                 -----------------    PAID-IN    & DEFERRED     COMPREHENSIVE  RETAINED
                                 SHARES     AMOUNT    CAPITAL   COMPENSATION    INCOME (LOSS)  EARNINGS      TOTAL
                                 ------     ------    -------   ------------    ------------- ----------  -----------
BALANCE, March 31, 1997        13,860,000  $14,000  $8,296,000    ($239,000)         $16,000  $7,710,000  $15,797,000
                                                                                                          -----------
Realized loss on securities
 available for sale                     -        -           -            -          (16,000)          -      (16,000)

 Net income                             -        -           -            -                -   1,221,000    1,221,000
                                                                                                          -----------
Comprehensive income                    -        -           -            -                -           -    1,205,000
Issuance of stock for the
 exercise of stock options        283,000        -     280,000            -                -           -      280,000
Issuance of below-market stock
 options                                -        -      21,000      (21,000)               -           -            -
Amortization of deferred
 compensaton                            -        -           -      124,000                -           -      124,000
Payment on employee note
 receivable                             -        -           -       30,000                -           -       30,000
Revision on estimate of income
 tax benefit on disqualifying
 dispositions                           -        -    (207,000)           -                -           -     (207,000)
Income tax benefit of
 disqualifying dispositions             -        -      40,000            -                -           -       40,000
Income tax benefit of non-
 qualified option exercises             -        -      37,000            -                -           -       37,000

                               ----------   ------   ---------    ----------      ----------   ---------   ----------

BALANCE, March 31, 1998        14,143,000   14,000   8,467,000     (106,000)               -   8,931,000   17,306,000
Net income                              -        -           -            -                -   5,418,000    5,418,000
Issuance of stock for the
 exercise of stock options        109,000        -      36,000            -                -           -       36,000
Issuance of below-market stock
 options                                -        -      90,000      (90,000)               -           -            -
Amortization of deferred
 compensation                           -        -           -      120,000                -           -      120,000
Income tax benefit of
 disqualifying dispositions             -        -      83,000            -                -           -       83,000
Income tax benefit of non-
 qualified option exercises             -        -      64,000            -                -           -       64,000
                               ----------   ------   ---------     --------       ----------  ----------   ----------

BALANCE, March 31, 1999        14,252,000   14,000   8,740,000      (76,000)               -  14,349,000   23,027,000

Net income                              -        -           -            -                -   1,942,000    1,942,000
Issuance of stock for the
 exercise of stock options         25,000        -      15,000            -                -           -       15,000
Issuance of below-market
 stock options                          -        -      10,000      (10,000)               -           -            -
Amortization of deferred
 compensation                           -        -           -       46,000                -           -       46,000
Income tax benefit of
 disqualifying dispositions             -        -       7,000            -                -           -        7,000
Income tax benefit of non-
 qualified option exercises             -        -      21,000            -                -           -       21,000
                               ----------  -------  ----------     ---------      ---------- -----------  -----------

BALANCE, March 31, 2000        14,277,000  $14,000  $8,793,000     ($40,000)      $        - $16,291,000  $25,058,000
                               ==========  =======  ==========     =========      ========== ===========  ===========
</TABLE>

The accompanying notes are an integral part of these financial statements.

<PAGE> 26
                                  SYNTHETECH, INC.

                               STATEMENT OF CASH FLOWS
                               -----------------------
<TABLE>
<CAPTION>
<S>                                    <C>               <C>           <C>
For The Year Ended March 31,                2000          1999         1998
----------------------------             ----------    ----------   ----------
CASH FLOWS FROM OPERATING ACTIVITIES:
Net income                               $1,942,000    $5,418,000   $1,221,000
Adjustments to reconcile net income
 to net cash provided by operating
 activities:
  Depreciation, amortization and other     1,936,000    1,351,000    1,014,000
    Amortization of deferred compensation     46,000      120,000      108,000
    Realized gain on securities available
     for sale                                      -            -      (25,000)
    (Benefit) provision for deferred income
     taxes                                   (21,000)     224,000      127,000
    (Increase) decrease in assets:
      Accounts receivable, net               981,000   (1,944,000)    (775,000)
      Inventories                           (753,000)    (175,000)  (1,297,000)
      Prepaid expenses                        (1,000)     (88,000)     (32,000)
      Income tax receivable                 (137,000)           -      798,000
      Other current assets                   (26,000)      19,000      (20,000)
    Increase (decrease) in liabilities:
      Accounts payable and accrued
       liabilities                        (1,815,000)   1,074,000      201,000
      Deferred revenue                       500,000     (203,000)     203,000
                                          ----------   ----------   ----------
        Net cash provided by operating
         activities                        2,652,000    5,796,000    1,523,000
                                          ----------   ----------   ----------
CASH FLOWS FROM INVESTING ACTIVITIES:
   Property, plant and equipment
    purchases, net                        (3,746,000)  (3,472,000)  (4,089,000)
   Proceeds from sale of securities
    available for sale and redemption
    of securities available for sale               -            -      635,000
   Employee notes receivable                       -            -       30,000
                                          ----------   ----------   ----------
        Net cash used by investing
         activities                       (3,746,000)  (3,472,000)  (3,424,000)
                                          ----------   ----------   ----------
CASH FLOWS FROM FINANCING ACTIVITIES:
   Principal payments under long-term
    debt obligations                         (15,000)     (13,000)     (13,000)
   Proceeds from stock option exercises
    and related tax benefits                  43,000      183,000      150,000
                                          ----------   ----------   ----------
        Net cash provided by
         financing activities                 28,000      170,000      137,000
                                          ----------   ----------   ----------
NET INCREASE (DECREASE) IN CASH
 AND CASH EQUIVALENTS                     (1,066,000)   2,494,000   (1,764,000)

CASH AND CASH EQUIVALENTS AT
 BEGINNING OF YEAR                         7,470,000    4,976,000    6,740,000
                                          ----------   ----------   ----------
CASH AND CASH EQUIVALENTS AT
 END OF YEAR                              $6,404,000   $7,470,000   $4,976,000
                                          ==========   ==========   ==========
NON-CASH INVESTING AND FINANCING
 ACTIVITIES:
   Issuance of stock options at
    below fair value                        $10,000       $90,000      $21,000
   Mature shares exchanged for
    the exercise of stock options           $94,000      $401,000     $480,000

</TABLE>

The accompanying notes are an integral part of these financial statements.

<PAGE> 27




                         SYNTHETECH, INC.
                         ----------------
                  NOTES TO FINANCIAL STATEMENTS
                  -----------------------------

NOTE A.   GENERAL AND BUSINESS

          Synthetech, Inc., an Oregon corporation, specializes in
          developing  and   producing  Peptide  Building   Blocks
          (PBBs),  which are chemically modified forms of natural
          amino  acids  and  synthetic  non-natural  amino  acids
          (Specialty Amino Acids)  using a combination of organic
          chemistry  and biocatalysis.   The Company's  PBBs  are
          used  by pharmaceutical companies to make a wide  range
          of  peptide-based drugs under development  and  on  the
          market    for   the   treatment   of   AIDS,    cancer,
          cardiovascular  and other diseases.   The  Company  has
          established a worldwide reputation in a unique  product
          and  technology  area  as a leading  supplier  for  all
          phases  of  the  drug development cycle from  discovery
          through market launch.

NOTE B.   SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES
          ------------------------------------------
          Use   of   Estimates:   The  preparation  of  financial
          statements  in  conformity with  accounting  principles
          generally  accepted  in  the  United  States   requires
          management  to  make  estimates  and  assumptions  that
          affect  the  reported amounts of assets and liabilities
          and disclosure of contingent assets and liabilities  at
          the  date  of the financial statements and the reported
          amounts  of revenues and expenses during the  reporting
          period.    Actual  results  could  differ  from   those
          estimates.

          Cash  and  Cash Equivalents:  Cash and cash equivalents
          include demand cash and all investments purchased  with
          a maturity at acquisition of three months or less.

          Inventories:   Inventories are stated at the  lower  of
          cost  or  market, determined on the first-in, first-out
          (FIFO)  basis.   Cost  utilized for inventory  purposes
          include labor, material, and manufacturing overhead.

          Securities Available for Sale:  In February  1998,  the
          Company  sold the last of its securities available  for
          sale.   Any  unrealized  gains  or  losses  have   been
          reflected  as  a  separate component  of  shareholders'
          equity   in  accordance  with  Statement  of  Financial
          Accounting Standards ("SFAS")  No. 115.

          Property,  Plant  and Equipment:  Property,  plant  and
          equipment  are  recorded  at  cost.   Depreciation  and
          amortization  are provided on the straight-line  method
          over  seven  to  forty  years for  buildings  and  land
          improvements,  and  five to seven years  on  all  other
          property.  When property is sold or retired,  the  cost
          and  accumulated  depreciation  are  removed  from  the
          accounts and the resulting gain or loss is included  in
          income.

<PAGE> 28

NOTE B.   SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (CONTINUED)
          ------------------------------------------------------
          Revenue  Recognition:  Sales of products are recognized
          when  products are shipped and title and risk  of  loss
          have been passed to the customer.  The Company has  not
          experienced  any significant history of  sales  returns
          and  thus,  no  reserve  for  sales  returns  has  been
          provided.

          Concentrations  of Credit Risk:  Financial  instruments
          which  potentially expose the Company to concentrations
          of   credit   risk   consist  primarily   of   accounts
          receivable.  At  March  31,  2000,  two  customers  had
          accounts  receivable balances of 68% and 15%  of  total
          accounts  receivable.  At March 31, 1999,  3  customers
          had accounts receivable balances of 53%, 17% and 12% of
          total accounts receivable.

          Research   and   Development   Costs:    Research   and
          development costs are expensed as incurred.

          Other  Assets:  Other assets primarily represent patent
          costs, which are amortized over the useful life of  the
          patent.

          Earnings Per Share:  Basic earnings per share (EPS) are
          computed by dividing net income by the weighted average
          number of shares of common stock outstanding during the
          period.   Diluted  earnings per share are  computed  by
          dividing  net income by the weighted average number  of
          shares  of  common  stock and common stock  equivalents
          outstanding  during  the period, calculated  using  the
          treasury stock method as defined in SFAS No. 128.   The
          following  is  a reconciliation of the shares  used  to
          calculate basic earnings per share and diluted earnings
          per share:

<TABLE>
<CAPTION>
<S>                                       <C>      <C>          <C>
                                           2000       1999         1998
                                           ----       ----         ----
         Weighted average shares
          outstanding for basic EPS     14,256,761  14,200,399   13,921,164

         Dilutive effect of common
          stock options issuable
          under treasury stock method       37,938      57,708      149,809
                                        ----------  ----------   ----------
         Weighted average common and
          common equivalent shares
          outstanding for diluted EPS   14,294,699  14,258,107   14,070,973
                                        ==========  ==========   ==========
</TABLE>
          The  following  common stock equivalents were  excluded
          from  the earnings per share computation because  their
          effect would have been anti-dilutive:
<TABLE>
<CAPTION>
<S>                                     <C>           <C>          <C>
                                          2000        1999          1998
                                          ----        ----          ----
          Common stock options
           outstanding                   523,800     523,800       482,300
</TABLE>

<PAGE> 29

NOTE B. SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (CONTINUED)
        -----------------------------------------------------
          Supplemental cash flow disclosures are as follows:
<TABLE>
<CAPTION>
<S>                                       <C>          <C>         <C>

            Cash Paid During The Year For:

                                                2000       1999         1998
                                                ----       ----         ----
            Income Taxes                    $1,640,000  $2,702,000  $  419,000
            Interest                        $   14,000  $   17,000  $   17,000

</TABLE>


          Comprehensive Income: In  1998,  the Company adopted
          SFAS No. 130, "Reporting Comprehensive Income."  The
          source  of  comprehensive income  for  the  Company,
          other than  net  income, is  losses  on   marketable
          securities  available  for  sale.  The  Company  has
          elected  to  disclose  comprehensive income  in  the
          Statements of Shareholders' Equity and Comprehensive
          Income.

          Segment Reporting: The Company adopted SFAS No. 131,
          "Disclosures  about  Segments of  an  Enterprise and
          Related Information" for the year ended March 31, 1999.
          Based upon definitions contained within SFAS No.  131,
          the Company has determined that it operates in one segment.

          New Accounting Pronouncement: In June 1999, the FASB
          issued Statement of Financial Accounting Standards  No. 137,
          "Accounting  for  Derivative  Instruments  and  Hedging
          Activities" ("SFAS 137").  SFAS 137 is an amendment  to
          Statement  of Financial Accounting Standards  No.  133,
          "Accounting  for  Derivative  Instruments  and  Hedging
          Activities."   SFAS  137  establishes  accounting   and
          reporting  standards  for  all derivative  instruments.
          SFAS  137 is effective for fiscal years beginning after
          June 15, 2000.  The Company does not currently have any
          derivative  instruments  and,  accordingly,  does   not
          expect  the adoption of SFAS 137 to have an  impact  on
          its financial position or results of operations.

<PAGE> 30



NOTE C.   INVENTORIES
          -----------

          The major components of inventories are as follows:
<TABLE>
<CAPTION>
<S>                                 <C>           <C>

                                             March 31,
                                             ---------
                                         2000          1999
                                         ----          ----
          Finished products         $  1,666,000   $ 1,206,000
          Work-in-process                943,000       824,000
          Raw materials                1,503,000     1,329,000
                                       ---------     ---------
                                    $  4,112,000   $ 3,359,000
                                    ============   ===========
</TABLE>


NOTE D.   PROPERTY, PLANT AND EQUIPMENT
          -----------------------------
          Property, plant and equipment consist of the following:
<TABLE>
<CAPTION>
<S>                                <C>            <C>

                                             March 31,
                                             ---------
                                        2000           1999
                                        ----           ----
          Land                    $     91,000   $     91,000
          Buildings                  5,139,000      4,446,000
          Machinery and equipment   10,767,000      7,293,000
          Laboratory equipment         469,000        400,000
          Furniture and fixtures       290,000        283,000
          Vehicles                     132,000        132,000
          Construction in progress   1,887,000      2,600,000
                                    ----------     ----------
                                    18,775,000     15,245,000
          Less:
          Accumulated depreciation   5,400,000      3,684,000
                                  ------------   ------------
                                  $ 13,375,000   $ 11,561,000
                                  ============   ============
</TABLE>
<PAGE> 31

NOTE E.  INCOME TAXES
         ------------
          The  Company accounts for income taxes under the  asset
          and  liability  method as defined by the provisions  of
          Statement  of  Financial Accounting Standards  No.  109
          (SFAS  109), "Accounting for Income Taxes." Under  this
          method,  deferred income taxes are recognized  for  the
          future   tax  consequences  attributable  to  temporary
          differences  between the financial  statement  carrying
          amounts  and  tax  balances  of  existing  assets   and
          liabilities.   Deferred tax assets and liabilities  are
          measured  using the enacted rates expected to apply  to
          taxable  income  in  the  years which  those  temporary
          differences are expected to be recovered or settled.

          The  provision for income taxes in fiscal 2000,  fiscal
          1999  and fiscal 1998 included a deferred tax (benefit)
          provision   of   ($21,000),  $224,000   and   $127,000,
          respectively.

          Total deferred tax assets and liabilities at March  31,
          2000  were $140,000 and $482,000, respectively.   Total
          deferred tax assets and liabilities at March 31,  1999,
          were  $133,000 and $496,000, respectively. Individually
          significant  differences included book/tax depreciation
          differences  which  were recorded  as  a  deferred  tax
          liability  of $482,000 and $496,000 at March  31,  2000
          and March 31, 1999, respectively.

          The  reconciliation between the effective tax rate  and
          the statutory federal income tax rate is as follows:
<TABLE>
<CAPTION>
<S>                                  <C>      <C>      <C>
                                      2000      1999     1998
                                      ----      ----     ----
  Statutory federal tax rate          34.0%     34.0%    34.0%
  State taxes                          4.4%      4.4%     2.5%
  Foreign sales corporation
   benefit                            (5.7)%    (0.6)%   (1.5)%
  Other                                0.1%     (1.3)%    1.5%
                                      ------    ------   ------
  Effective tax rate                  32.8%     36.5%    36.5%
                                      =====     =====    =====
</TABLE>

NOTE  F.  LINE OF CREDIT
          --------------
          The  Company has a line of credit available with a bank
          in the amount of $1 million with an applicable interest
          rate  equal to the bank's prime lending rate which  was
          9.0%   at  March  31,  2000.   There  were  no  amounts
          outstanding  under this loan at the end of  the  fiscal
          year.  This line of credit is renewable on September 1,
          2000.

<PAGE> 32

NOTE G.   NOTE PAYABLE
          ------------
          In  1997, the Company entered into a note payable  with
          the  City  of  Albany for payment of wastewater  system
          development  charges  assessed in connection  with  the
          Company's plant expansion.  The note bears interest  of
          9.0%  and  is  due  in monthly installments  of  $2,459
          through  February  2007.  The note is  secured  by  the
          Company's property, plant and equipment.

NOTE H.   SHAREHOLDERS' EQUITY
          --------------------
          In  July 1998, the Company adopted a Shareholder Rights
          Plan  (the "Rights Plan").  Under the Rights Plan,  the
          Company  declared  a  dividend  of  one  common   share
          purchase  right (a "Right") for each outstanding  share
          of common stock outstanding at the close of business on
          August  4,  1998.   The  Rights are  attached  to,  and
          automatically trade with, the outstanding shares of the
          Company's common stock.  Under certain conditions, each
          right may be  exercised to purchase one share of common
          stock at a purchase price of $30 per share, subject  to
          adjustment.   In  the  event that  a  person  or  group
          acquires  15%  or more of the Company's  common  stock,
          each  Right  will  entitle all  other  shareholders  to
          purchase from the Company common stock having a  market
          value  equal  to two times the exercise  price  of  the
          Right.   In addition, if the Company is acquired  in  a
          merger or other business combination transaction or 50%
          or more of its consolidated assets or earning power are
          sold,  proper  provision will  be  made  so  that  each
          shareholder with unexercised Rights will be entitled to
          purchase  common stock of the acquirer with a value  of
          twice the exercise price of the Rights.  The Company is
          entitled  to redeem the Rights at $.0001 per  Right  at
          any  time prior to the earlier of the expiration of the
          Rights in July 2008 or the time that a person or  group
          has  acquired a 15% position.  The Rights do  not  have
          voting or distribution rights.

          Under  the Amended and Restated 1990 Stock Option  Plan
          1,600,000 shares were authorized for issuance.  A total
          of  1,491,160 options were granted under this plan.   A
          total  of  1,436,050  options have been  exercised  and
          55,110 options have been cancelled as of March 31, 2000
          under  the  plan  since  its  inception.   The  options
          granted  under  this plan vest over a two  year  period
          from  the  beginning of the fiscal year  in  which  the
          options are granted and a maximum term of 5 years.

<PAGE> 33

NOTE H.   SHAREHOLDERS' EQUITY (CONTINUED)
          --------------------------------
          The 1995 Incentive Compensation Plan authorized 902,000
          shares of the Company's stock to be issued.  This  plan
          is the successor to the Amended and Restated 1990 Stock
          Option Plan.  No further grants will be made under  the
          original  plan.  A total of 983,000 options  have  been
          granted  under  this plan.  A total of  20,500  options
          have  been  exercised  and 220,200  options  have  been
          cancelled as of March 31, 2000 under the plan since its
          inception.   The  options  granted  under   this   plan
          generally vest 50% after 1 year and 100% after 2  years
          from  the  beginning of the fiscal year  in  which  the
          options are granted.  However, to a lesser extent, some
          options vest from 50% after one year of employment  and
          100% after 2 years of employment, and some options vest
          in  less  than  a  year and others up  to  five  years.
          Options granted under this plan have a maximum term  of
          10  years.   The 1995 Incentive Compensation  Plan  was
          amended  in  November 1996 to permit granting  of  non-
          qualified options to directors who are not employees of
          the Company.

          During  1995, the Financial Accounting Standards  Board
          issued SFAS 123 which defines a fair value based method
          of  accounting for an employee stock option or  similar
          equity instrument and encourages all entities to  adopt
          that  method  of  accounting for all of their  employee
          stock  compensation plans.  However, it also allows  an
          entity  to  continue to measure compensation  cost  for
          those  plans using the method of accounting  prescribed
          in  APB  25.   Entities electing  to  remain  with  the
          accounting in APB 25 must make pro forma disclosures of
          net income and, if presented, earnings per share, as if
          the  fair  value based method of accounting defined  in
          the Statement had been applied.

          The  Company has elected to account for its stock-based
          compensation plan under APB 25.  However,  the  Company
          has  computed,  for pro forma disclosure purposes,  the
          value of all options granted during fiscal 2000, fiscal
          1999  and  fiscal 1998 using the Black-Scholes  option-
          pricing  model  as prescribed by SFAS  123,  using  the
          following  weighted average assumptions for  grants  in
          fiscal 2000, fiscal 1999 and fiscal 1998:
<TABLE>
<CAPTION>
<S>                               <C>          <C>          <C>

          Fiscal Year                 2000         1999         1998
          -----------                 ----         ----         ----
          Risk-free interest rate     5.50%        5.50%        6.49%
          Expected dividend yield        0%           0%           0%
          Expected life             3.84 years   3.81 year    3.60 years
          Expected volatility           55%          55%          57%
</TABLE>


          The  total value of options granted during fiscal 2000,
          fiscal  1999 and fiscal 1998  would be amortized  on  a
          pro forma basis over the vesting period of the options.
          Options generally vest equally over two years.  If  the
          Company  had accounted for these options in  accordance
          with SFAS 123, the Company's net income and
<PAGE> 34

NOTE H.   SHAREHOLDERS' EQUITY (CONTINUED)
         ---------------------------------
          earnings per share would have decreased as reflected in
          the following pro forma amounts:
<TABLE>
<CAPTION>
<S>                                  <C>           <C>         <C>
                                         Year ended March 31,
                                         --------------------
                                        2000        1999         1998
                                        ----        ----         ----
          Net income:
             As reported            $ 1,942,000  $ 5,418,000  $ 1,221,000
             Pro forma              $ 1,453,000    4,761,000      322,000
          Basic earnings per
           share:
             As reported                  $0.14        $0.38        $0.09
             Pro forma                    $0.10        $0.33        $0.02
          Diluted earnings per
           share:
             As reported                  $0.14        $0.38        $0.09
             Pro forma                    $0.10        $0.33        $0.02
</TABLE>

          Using the Black-Scholes methodology, the total value of
          options  granted  during fiscal 2000, fiscal  1999  and
          fiscal   1998  was  $299,000,  $743,000  and  $873,000,
          respectively, which would be amortized on a  pro  forma
          basis  over  the  vesting period of the  options.   The
          weighted  average fair value of options granted  during
          fiscal  2000,  fiscal 1999 and fiscal 1998  was  $2.18,
          $3.05 and $3.45, respectively.

          Activity  under  the  Amended and Restated  1990  Stock
          Option Plan and 1995 Incentive Compensation Plans  over
          the last three fiscal years is summarized as follows:

<TABLE>
<CAPTION>
<S>                        <C>     <C>     <C>      <C>      <C>      <C>

                                            Year ended March 31,
                                            --------------------
                                 2000           1999              1998
                             ------------   -------------     --------------
                                     Wtd.             Wtd.              Wtd.
                                     Avg.             Avg.              Avg.
                             Shares   Ex.    Shares   Ex.      Shares   Ex.
                                     Price           Price              Price
                             ------  -----   ------  -----     ------   -----
Options outstanding
 at beginning of year       659,513  $6.26   749,400   $5.85   913,810  $4.06
Granted                     137,000  $4.32   244,000   $5.64   253,000  $7.05
Exercised                   (41,713) $2.60  (173,887)  $2.52  (373,710) $2.04
Cancelled                   (22,000) $5.03  (160,000)  $7.45   (43,700) $8.02
                            -------  -----   -------   -----   -------  -----
Options outstanding at
 at end of year             732,800  $6.15   659,513   $6.26   749,400  $5.85
                            =======  =====   =======   =====   =======  =====
Exerciseable at end
 of year                    488,300  $6.67   346,113   $6.40   381,183  $4.48

Weighted average fair
 value of optons granted
 at market value                  -  $2.13         -   $2.84         -  $3.41
Weighted average fair
 value of options granted
 at below market value            -  $3.18         -   $5.45         -  $7.02
</TABLE>

<PAGE> 35

NOTE H.   SHAREHOLDERS' EQUITY (CONTINUED)
          --------------------------------

          The  following  table  sets forth  the  exercise  price
          range, number of shares outstanding at March 31,  2000,
          weighted  average remaining contractual life,  weighted
          average  exercise  price, number of exercisable  shares
          and  weighted  average  exercise price  of  exercisable
          options by groups of similar price and grant date:
<TABLE>
<CAPTION>
<S>         <C>          <C>         <C>        <C>          <C>
                  Options Outstanding            Options Exercisable
            ---------------------------------   ---------------------
Exercise    Outstanding  Remaining   Wtd. Avg.               Wtd. Avg.
Price          Shares    Contractual  Exercise  Exercisable  Exercise
Range        at 3/31/00  Life (Years)  Price       Options    Price
-----------  ----------  -----------  --------  ------------ -------
$0.30-$1.08    24,500       8.41       $0.84        9,500     $0.84
$1.72-$1.81    50,000       6.58       $1.81       50,000     $1.81
$2.22-$4.56   144,000       8.73       $4.49       12,500     $4.38
$6.25-$8.50   514,300       7.15       $7.29      416,300     $7.46

</TABLE>

NOTE I.   401(k) PROFIT SHARING PLAN
          --------------------------
          The Company established a 401(k) Profit Sharing Plan on
          April  1,  1992.   This  plan is  offered  to  eligible
          employees,  who may elect to contribute up  to  15%  of
          compensation   and   includes   a   Company    matching
          contribution.   The Company's matching contribution  is
          $.50,  $.75 and $1.00 for each $1.00 contributed up  to
          10%  of compensation corresponding to length of service
          with  the  Company.   The Company contribution  becomes
          fully  vested  for  each  employee  after  5  years  of
          employment.   The  Company  matching  contribution  for
          fiscal  years 2000, 1999 and 1998 was $73,000,  $77,000
          and $46,000, respectively.
<PAGE> 36


NOTE J.   SEGMENT INFORMATION
          -------------------
          Long-lived assets, other than in the United States, are
          not material.

          Significant Customers:  During fiscal year 2000,  three
          customers accounted for approximately 29%, 19% and  14%
          of  revenues.   During fiscal year 1999, two  customers
          accounted  for  44% and 20% of revenues. During  fiscal
          year  1998, two customers accounted for 23% and 11%  of
          revenues.

          The following table reflects sales and percent of total
          sales  by  geographic area for the  year ended March 31,
<TABLE>
<CAPTION>
<S>                 <C>        <C>     <C>         <C>    <C>          <C>
                          2000                1999                1998
                   ------------------  ------------------  -------------------
  United States    $ 5,738,000  47.3%  $16,680,000  72.1%  $ 5,472,000   65.7%
  Europe             4,807,000  39.6%    5,688,000  24.6%    2,606,000   31.3%
  Mexico             1,522,000  12.6%      552,000   2.4%            -      -
  Japan                 53,000   0.5%      198,000   0.9%      205,000    2.5%
  Other                 12,000     -        15,000     -        38,000    0.5%
                   -----------  -----  -----------  -----   ----------   -----
       Total       $12,132,000   100%  $23,133,000   100%  $ 8,321,000    100%
                   ===========         ===========         ===========
</TABLE>

NOTE K.   COMMITMENTS AND CONTINGENCIES
          -----------------------------
          The   Company   is  a  party  to  a  legal  proceeding.
          Management believes that the outcome of such proceeding
          will  not  have  a  material effect  on  the  business,
          financial  position  or results of  operations  of  the
          Company.
<PAGE> 37



Supplementary Financial Data
----------------------------
          The financial statements and notes thereto required by
          this item begin on page 20 of this document.  Unaudited
          quarterly financial data for each of the eight quarters
          in the two-year period ended March 31, 2000 is as
          follows:

<TABLE>
<CAPTION>
<S>                      <C>      <C>       <C>        <C>

                                  Year Ended March 31, 2000
                                  -------------------------
(in thousands, except       First    Second     Third     Fourth
 per share data)           Quarter   Quarter    Quarter   Quarter
                           -------   -------    -------   -------
Revenue                    $4,636    $3,370     $1,503    $2,623
Gross profit                2,007     1,365        135       689
Operating income (loss)     1,537       955       (243)      295
Net income (loss)           1,005       645        (92)      384
Basic and diluted earnings
 (loss) per share           $0.07     $0.05     ($0.01)    $0.03


                                  Year Ended March 31, 1999
                                  -------------------------
                            First    Second    Third      Fourth
                           Quarter   Quarter   Quarter    Quarter
                           -------   -------   -------    -------
Revenue                    $4,128    $5,327     $6,047     $7,631
Gross profit                1,593     2,320      2,423      3,814
Operating income            1,157     1,861      1,979      3,344
Net income                    754     1,193      1,267      2,204
Basic and diluted
 earnings per share         $0.05     $0.08      $0.09      $0.15

</TABLE>
<PAGE> 38


    ITEM 9.  CHANGES IN AND DISAGREEMENTS WITH ACCOUNTANTS ON
    ---------------------------------------------------------
               ACCOUNTING AND FINANCIAL DISCLOSURE
               -----------------------------------
Not applicable.

<PAGE> 39
                            PART III
                            --------
        ITEM 10.  DIRECTORS AND EXECUTIVE OFFICERS OF THE
        -------------------------------------------------
                           REGISTRANT
                           ----------
The following table sets forth certain information concerning the
executive officers, key employees and directors of the Company:
<TABLE>
<CAPTION>
<S>  <C>                             <C>     <C>

            Name                      Age             Position
            ----                      ---             --------
     M. ("Sreeni") Sreenivasan         51    President, Chief Executive
                                             Officer and Director

     Charles B. Williams               53    Vice President of Finance
                                             and Administration, Chief
                                             Financial Officer,Secretary,
                                             Treasurer, and Director

     Mitchell R. McVay                 49    Director of Engineering(1)

     Timothy D. Fitzpatrick            35    Director of R&D and Pilot
                                             Plant Operations(2)

     Joel D. Melka                     46    Director of Manufacturing

     Paul C. Ahrens                    48    Chairman of the Board

     Howard L. Farkas                  76    Director

     Edward M. Giles                   64    Director

     Page E. Golsan, III               62    Director

     Donald E. Kuhla, Ph.D.            57    Director(3)

</TABLE>
____________

(1)Mr. McVay resigned his position with the Company effective
   March 31, 2000.
(2)Mr. Fitzpatrick resigned his position with the Company
   effective June 1, 2000.
(3)Dr. Kuhla has advised the Company that he will not be standing
   for reelection as a Director at the Annual Meeting of Shareholders
   to be held July 20, 2000.



The  following  is a brief account of the business experience  of
each executive officer, key employee and director of the Company.

M. "Sreeni" Sreenivasan.  Mr. Sreenivasan has served as President
and  Chief  Executive Officer since 1995 and as  Chief  Operating
Officer from 1990 through 1995.  Mr. Sreenivasan has also  served
as a director since 1995. From 1988 to 1990 he was Executive Vice
President  and  General Manager and from  1987  to  1988  he  was
Director  of Manufacturing.  Previously, he worked for  Ruetgers-
Nease   Chemical  Co.  (bulk  pharmaceuticals  and   other   fine
chemicals)  for  13 years in various technical and  manufacturing
management  capacities, including 7 years  as  Plant  Manager  of
their  Augusta, Georgia plant. Mr. Sreenivasan received his  M.S.
in  Chemical Engineering from Bucknell University and his  M.B.A.
from Penn State University.

<PAGE> 40

Charles  B. Williams.  Mr. Williams has served as Vice  President
of Finance and Administration and Treasurer since 1990.  In 1995,
he  also  became  Chief Financial Officer  and   Secretary.   Mr.
Williams  has also served as a director since 1997.  Mr. Williams
is responsible for accounting, administration, finance, personnel
and  information systems.  From 1988 to 1990 Mr. Williams  served
as  the Controller.  Prior thereto, he was Controller for White's
Electronics, Inc. of Sweet Home, Oregon for 5 years. From 1976 to
1983  he  held  several accounting and financial  positions  with
Teledyne  Wah  Chang,  a  metals  producer  in  Albany,   Oregon.
Mr.  Williams earned his B.S. in Economics and M.B.A. from Oregon
State University.

Mitchell  R.  McVay.  Mr. McVay resigned his  position  with  the
Company  on  March 31, 2000.  He had been Director of Engineering
since  April  1, 1998. From 1996 to 1998 he served as  the  Plant
Engineer.  Previously  Mr. McVay worked  for  Salsbury  Chemicals
Inc.,  a  division of Cambrex Inc. (chemical manufacturing)  from
1983 to 1996 in various technical and management capacities,  his
last  position being the Manager of Engineering and  Maintenance.
Mr. McVay received his B.S. in Chemical Engineering from Texas  A
& M University.

Timothy  D.  Fitzpatrick. Mr. Fitzpatrick resigned  his  position
with  the Company on June 1, 2000.  He has served as Director  of
R&D  and  Pilot  Plant Operations of the since October  1,  1998.
From  1994 to 1998 he was the R&D Laboratory Manager. Previously,
he worked for Cortech, Inc. from 1993 to 1994 and Somatogen, Inc.
from  1992 to 1993 (both start-up biotechnology companies)  as  a
research scientist in new drug discovery.  Prior to 1992, he  was
a  research chemist in LHRH Drug Discovery at Abbott Laboratories
of   North   Chicago,  Illinois  (pharmaceutical   research   and
manufacturing).  Mr.  Fitzpatrick  holds  his  M.S.  in   Organic
Chemistry  from University of Wisconsin-Madison and his  B.S.  in
Chemistry from Montana Tech.

Joel  D.  Melka.  Mr.  Melka joined the Company  as  Director  of
Manufacturing in February 1999. From 1988 to 1999  he  worked  at
ChemDesign  Inc.  (custom  chemical  manufacturing)  in   various
capacities,  his  last position being Director of  Manufacturing.
From  1984 to 1988, he worked for Polaroid Corporation in various
manufacturing positions. Prior to 1984, he spent 5  years  as  an
officer  in  the U.S. Navy nuclear submarine service.  Mr.  Melka
received  his  M.S. in Chemistry from the University  of  British
Columbia  and  his B.S. in Chemistry from Michigan  Technological
University.

Paul  C.  Ahrens.  Mr. Ahrens has been a director of the  Company
since  its inception in 1981 and became Chairman of the Board  in
1995.   Since  1996  he  has been the founder  and  President  of
Groovie Moovies, Ltd., a film production company.  Mr. Ahrens,  a
founder  of the Company, served as President and Chief  Executive
Officer  of Synthetech from 1989 through March 1995.   From  1981
through  1989 he was the Vice President of Technology.   He  also
served as Secretary of the Company from 1981 through 1995.   From
1979  to  1980 Mr. Ahrens served as Vice President of Engineering
of   Colorado  Organic  Chemical  Company,  an  organic  chemical
manufacturing company located in Commerce City, Colorado.   Prior
thereto,  Mr.  Ahrens spent five years with Allied  Chemical  and
CIBA-Geigy   in  various  engineering  and  research  capacities.
Mr.  Ahrens  holds B.S. and M.S. degrees in Chemical  Engineering
from M.I.T.

Howard  L.  Farkas.  Mr. Farkas has served as a director  of  the
Company  since  1985.  Since 1981 he has been  the  President  of
Farkas  Group,  Inc.,  and since 1992 he has  been  President  of
Windsor  Gardens  Realty,  Inc., both of  which  are  engaged  in
general  real estate brokerage and management activities.    From

<PAGE> 41

1984  to  1996 he was also the managing director in Manistee  Gas
Limited  Liability  Company, which is in the gas  production  and
processing  business.  Mr.  Farkas  serves  as  Secretary  and  a
director  of  Acquisition  Industries,  Inc.,  a  publicly  owned
acquisition  and  merger  company.   Mr.  Farkas  serves  as  the
Chairman  of  the  Board  of Logic Devices,  Inc.,  a  Sunnyvale,
California  company specializing in CMOS digital  signal  process
semiconductor and SRAM chips.  Since May 1988 Mr. Farkas has also
been a vice president of G.A.S. Corp., which is a general partner
of  an  Oklahoma  limited partnership, Gas Acquisition  Services,
which  filed for bankruptcy under Chapter 11.  In September 1992,
Mr.  Farkas filed for personal protection under Chapter 7 of  the
federal  bankruptcy  laws and the court subsequently  entered  an
order  discharging his debts.  Though not presently in public  or
private practice, he has been a certified public accountant since
1951.  Mr.  Farkas received a B.S. (B.A.) from the University  of
Denver.

Edward M. Giles.  Mr. Giles has served as a director since  1997.
Since 1989 he has served as Chairman of The Vertical Group, Inc.,
a  venture capital investment firm.  He was also President of The
Vertical  Group  from  1989 to 1998.  Mr.  Giles  was  previously
President  of  F. Eberstadt & Co., Inc., a securities  firm,  and
Vice  Chairman  of  Peter B. Cannell & Co., Inc.,  an  investment
management  firm.   He  is  currently  a  director  of  McWhorter
Technologies,   Inc.  (chemical  company)  and  Ventana   Medical
Systems, Inc. (medical diagnostic company).  Mr. Giles received a
B.S.  in  Chemical Engineering from Princeton University  and  an
M.S. in Industrial Management from the Massachusetts Institute of
Technology.

Page E. Golsan, III.  Mr. Golsan has served as a director of  the
Company  since 1991.  Since 1986 he has been a principal of  P.E.
Golsan  &  Co.  (formerly Golsan Management Company),  a  private
capital  management firm.  From 1990 to 1992, Mr.  Golsan  was  a
senior advisor with Bane Barham & Holloway, registered investment
advisors  under the Investment Advisor Act of 1940.   Since  1990
Mr.  Golsan  has  been President and Chief Executive  Officer  of
Bridgetown  Capital, Inc., an investment company.  From  1987  to
1989  he  was the Executive Vice President of Calumet Industries,
Inc.,  Chicago,  Illinois (manufacturer and  marketer  of  petro-
chemicals  and other fine chemicals).  Prior to 1987 he  was  the
President  and  Chief  Operating  Officer  of  the  K&W  Products
Division   (specialty   chemical  manufacturing)   of   Berkshire
Hathaway, Inc. Mr. Golsan holds an M.A. in Finance from Claremont
Graduate  School of Business and a Doctorate in  Pharmacy  and  a
B.A.  in  Chemistry  and  Zoology, both from  the  University  of
Southern California.

Donald E. Kuhla, Ph.D.  Dr. Kuhla has served as a director  since
1997  and  has notified the Company that he will not be  standing
for   reelection  as  a  Director  at  the  Annual   Meeting   of
Shareholders to be held July 20, 2000.  Since 1998  he  has  been
President   and  Chief  Operating  Officer  of  Albany  Molecular
Research,  Inc. (contract research organization).  From  1994  to
1998, he was Vice President and Chief Technical Officer of Plexus
Ventures, Inc., a biotech consulting and investment firm.    From
1990 to 1994 Dr. Kuhla held senior management positions with  two
venture   capital   backed,  biotechnology  start-up   companies.
Previously,  he  was in research and development  and  operations
management positions with Pfizer Inc. and Rorer Group, Inc.,  his
last position at Rorer being Senior Vice President of Operations.
Dr.  Kuhla  is  a  director  of  NPS  Pharmaceuticals,  Inc.   (a
biotechnology drug discovery and development company).  Dr. Kuhla
received a B.A. in Chemistry from New York University and a Ph.D.
in Organic Chemistry from Ohio State University.

<PAGE> 42

Schedule 16(a) Beneficial Ownership Reporting Compliance
--------------------------------------------------------

Section 16(a) of the Securities Exchange Act of 1934, as amended,
requires  the Company's officers and directors, and  persons  who
own  more than 10% of a registered class of the Company's  equity
securities, to file reports of ownership on Form 3 and changes in
ownership  on  Form 4 or Form 5 with the Securities and  Exchange
Commission   ("SEC").    Such   officers,   directors   and   10%
shareholders  are  also  required by SEC  rules  to  furnish  the
Company with copies of all Section 16(a) forms they file.

Based  solely on its review of the copies of such forms  received
by it, or written representations from certain reporting persons,
the Company believes that, during the fiscal year ended March 31,
2000,  all  Section 16(a) filing requirements applicable  to  its
officers, directors and 10% shareholders were complied with.



                ITEM 11.  EXECUTIVE COMPENSATION
                --------------------------------

REPORT OF THE COMPENSATION COMMITTEE

The  Compensation  Committee sets, reviews  and  administers  the
executive compensation program of the Company and is comprised of
the  individuals  noted  below, each  of  whom  are  non-employee
directors of the Company.  The role of the Compensation Committee
is  to establish and approve salaries and other compensation paid
to  the  executive officers of the Company and to administer  the
Company's  stock option plan, in which capacity the  Compensation
Committee  reviews  and  approves  stock  option  grants  to  all
employees.

Compensation Philosophy.  Synthetech's compensation philosophy is
that  cash  compensation should be directly linked to the  short-
term  performance of the Company and that longer-term incentives,
such  as  stock options, should be aligned with the objective  of
enhancing shareholder value over the long term. The use of  stock
options clearly links the interests of the officers and employees
of  the  Company  to  the  interests  of  the  shareholders.   In
addition,  the  Compensation Committee believes  that  the  total
compensation package must be competitive with other companies  in
the  industry to ensure that the Company can continue to attract,
retain  and motivate key employees who are critical to the  long-
term success of the Company.

Components  of Executive Compensation.  The principal  components
of  executive  compensation are base salary,  bonuses  and  stock
options.

Base  salary is set based on competitive factors and the historic
salary structure for various levels of responsibility within  the
Company.  In addition, the Company relies on bonuses in order  to
emphasize the importance of performance.

The  equity  component  of executive compensation  is  the  stock
option  program.  Stock  options are generally  granted  when  an
executive  joins the Company and, typically, on an  annual  basis
thereafter.   The options granted to the executives vest  over  a
period of two years.  The purpose of the annual option grants  is

<PAGE> 43

to  ensure  that the executive always has options  that  vest  in
increments  over the following two-year period.  This provides  a
method   of  retention  and  motivation  for  the  senior   level
executives  of  the  Company and also aligns senior  management's
objectives with long-term stock price appreciation.

Other elements of executive compensation are participation  in  a
Company-wide  life  insurance,  long-term  disability  insurance,
medical benefits and ability to defer compensation pursuant to  a
401(k)  plan.  Matching Company contributions to the 401(k)  plan
of up to 10% of eligible base pay were made in fiscal 2000.

As a result of the decline in revenues and profits in fiscal
2000, the Compensation Committee did not grant bonuses to Mr.
Sreenivasan, the CEO, or any of the other executive officer. In
fiscal 1999, recognizing Mr. Sreenivasan's long term efforts on
behalf of the Company, the Compensation Committee granted him a
$45,000 one-time bonus payable over thirty-six months.  Mr.
Sreenivasan received $15,000  of this bonus in fiscal 2000 and
$7,500 in fiscal 1999.  Consistent with its policy to create
longer-term incentives, the Compensation Committee granted stock
options in fiscal 2000 to the executive officers, including a
14,000 share option to Mr. Sreenivasan.



                              Paul C. Ahrens
                              Edward M. Giles
                              Page E. Golsan III
                              COMPENSATION COMMITTEE OF THE BOARD
                              OF DIRECTORS

Compensation Committee Interlocks and Insider Participation.  The
members  of  the  Compensation  Committee  are  Paul  C.  Ahrens,
Edward  M. Giles and Page E. Golsan III.  Mr. Ahrens is  formerly
an officer of the Company.

<PAGE> 44

Summary of Cash and Certain Other Compensation
----------------------------------------------
The following table provides certain summary information
concerning compensation paid by the Company to the Company's
Chief Executive Officer and Chief Financial Officer (the "Named
Persons") for the fiscal years ended March 31, 2000, 1999 and
1998 (no other officer or key employee received a salary and
bonus exceeding $100,000 during fiscal 2000):
<TABLE>
<CAPTION>
<S>                            <C>      <C>       <C>         <C>         <C>
                                            Summary Compensation Table
                                            --------------------------
                                                              Long-Term        All Other
                                   Annual Compensation       Compensation  Compensation($)(2)
                              -----------------------------  ------------  ------------------
Name and Principal                                              Stock
Position                       Year(1)  Salary($)  Bonus($)    Options(#)
-------------------------      -------  ---------  ---------   ----------     ------
M. ("Sreeni") Sreenivasan        2000   180,000    15,000(3)    14,000         5,800
President & Chief                1999   165,000    71,500(3)    24,000        11,200
Executive Officer                1998   150,000         -       25,000        12,500

-------------------------
Charles B. Williams              2000   110,000         -       14,000        10,000
Vice President of                1999    99,000    36,000       19,000         9,900
Finance and Adminsitration       1998    88,000         -       20,000         7,950
& Chief Financial Officer

</TABLE>
_______________________

(1)Fiscal year ended March 31.
(2)Unless otherwise footnoted, represents Company contributions
   to the account of the Named Persons under the Company's 401(k) plan.
(3)In  fiscal 1999, Mr. Sreenivasan was granted a special $45,000
   bonus payable  over  thirty-six  months.  The bonus figures
   include  a  $7,500 payment in fiscal 1999 and a $15,000 payment
   in fiscal 2000.   See "Report of the Compensation Committee" above.

<PAGE> 45

Stock Option Grants in Last Fiscal Year
---------------------------------------
The following table provides information, with respect to the
Named Persons, concerning the grant of stock options during
fiscal year 2000.
<TABLE>
<CAPTION>
<S>                        <C>         <C>          <C>      <C>         <C>        <C>

                            Stock Options Grants in the Last Fiscal Year(1)
                            -----------------------------------------------
                                                                          Potential Realizable
                                                                          Value at Assumed Annual
                                       Individual Grants                  Rates of Stock Price
                          ---------------------------------------------   Appreciation (Through
                                                                             Expiration Date)
                             Options                Exercise
Name                         Granted     % of Total   Price   Expiration   5% per     10% per
                          (# of Shares)  Options(2) ($/Sh)(3)    Date      year(4)    year(4)
------------------------- -------------  ---------- --------- ----------  --------   --------
M. ("Sreeni") Sreenivasan    14,000        10.2%     $4.56    May 2009    $40,040    $101,780

Charles B. Williams          14,000        10.2%     $4.56    May 2009    $40,040    $101,780

</TABLE>
_______________________

(1)The  Company  has  not granted any stock  appreciation  rights (SARs).
(2)Based on an aggregate of 137,000 options being granted to  all employees
   during the fiscal year ended March 31, 2000.
(3)These  options were granted under the Company's 1995 Incentive Compensation
   Plan  in May 1999.  Each option  has  an  exercise price  equal to the
   fair market value of the Company's  Common Stock  as  of the date of the
   grant. These grants vest  annually over a two-year period ending April 2001
   for each individual.
(4)The  5% and 10% assumed rates of appreciation are mandated  by the  rules
   of the Securities and Exchange Commission and do  not represent the Company's
   estimate or projection of future  prices for its Common Stock.

<PAGE> 46

Stock Option Exercises in Last Fiscal Year and Fiscal Year-End Stock Option
---------------------------------------------------------------------------
Values
------
The following table provides information, with respect to the Named Persons,
concerning the options granted to them during the last fiscal year and the
options held by them at March 31, 2000.

<TABLE>
<CAPTION>
<S>                      <C>       <C>     <C>          <C>           <C>
        Option Exercises in Last Fiscal Year and Fiscal Year End Stock Option Values
        ----------------------------------------------------------------------------
                           Shares
                          Acquired
                            On      Value    Number of Unexercised      Value of Unexercised
                          Exercise Realized   Options at Fiscal Year      In-the-Money Options
                            (#)      ($)              End               at Fiscal Year End($)(1)
                                            -------------------------- --------------------------
Name                                        Exercisable  Unexercisable Exercisable  Unexercisable
-------------------------  ------   ------- -----------  ------------- -----------  -------------
M. ("Sreeni") Sreenivasan  18,113   $50,535    87,000        26,000         $0           $0

Charles B. Williams             0        $0    61,500        23,500         $0           $0

</TABLE>
_______________________

(1)Represents the difference between the exercise price of the options with
   exercise prices below $4.19 and the $4.19 closing price of the Company's
   Common Stock on March 31, 2000.


Comparison of Total Cumulative Shareholder Equity
-------------------------------------------------
The  following  graph  provides a comparison  of  the  five  year
cumulative  total stockholder return on (i) the Company's  Common
Stock,  (ii) the Nasdaq Stock Market Index (U.S.), and (iii)  the
S&P  Specialty Chemicals Index. The graph assumes that  $100  was
invested  on  March  31, 1995 in the Company  Common  Stock,  the
Nasdaq Stock Market Index (U.S.), and the S&P Specialty Chemicals
Index,  and  that all dividends were reinvested.  Historic  stock
price  performance is not necessarily indicative of future  stock
price performance.

Edgar Representation of Data Points Used in Printed Graphic
-----------------------------------------------------------
<TABLE>
<CAPTION>
<S>             <C>             <C>            <C>
                                Nasdaq Stock   S&P Specialty
                 Synthetech,    Market Index     Chemicals
                    Inc.           (U.S.)          Index
                 -----------    ------------   -------------
         1995     $ 100.00        $ 100.00        $ 100.00
         1996       290.84          135.80          129.10
         1997       369.61          150.95          116.05
         1998       299.95          228.88          147.03
         1999       212.07          309.19          123.89
         2000       203.01          574.04          119.88
</TABLE>

          All data points are at March 31.

<PAGE> 47

Employment Agreements
---------------------

In  July,  1997,  the Company entered into Employment  Agreements
with  Messrs.  Sreenivasan, Knutson and  Williams  (collectively,
"Executives"  and  individually, "Executive").   In  addition  to
providing for an annual base salary, the Agreements have  certain
noncompetition and nonsolicitation provisions.  Pursuant  to  the
Agreements, the Company will pay the Executives certain  payments
after  termination of employment for any reason other than death.
Specifically, the Company will pay an amount equal  to  the  base
salary  earned  by the Executive during the twelve  month  period
immediately preceding the date of termination plus an  additional
amount  for  one year of health insurance coverage.  The  Company
has  certain  rights to extend the agreements and payments  under
the  Agreement for a total of 24 months after termination  of  an
Executive's  employment.  In the event the Executive  should  die
during  the  payment  period,  the Company's  payment  obligation
immediately  terminates.  In May 1998, Mr. Knutson  resigned  his
employment and has received payments under this Agreement for the
immediate twelve month period thereafter.

Compensation of Directors
-------------------------
In  fiscal  1997, the Company established a policy to  grant  all
current  directors who are not employees (other than Mr.  Ahrens,
who  is a founder of the Company) a nonqualified stock option for
15,000 shares vesting at the rate of 3,000 shares at the next and
each  of  the subsequent four annual shareholder meetings.   This
option  is  intended  to provide the outside  director  with  the
equivalent  of  an annual grant of 3,000 shares and  the  Company
does not anticipate granting any additional options until the end
of  the fifth year.  The exercise price of these options will  be
set  at the fair market value of the Common Stock on the date  of
the grant.

Since fiscal 1998, the Company has provided directors who are not
employees  of the Company an annual fee of $4,000.   The  Company
also established a policy to grant all new directors who are  not
employees a one-time nonqualified stock option for 10,000  shares
which  vests  immediately.   Thus,  new  directors  who  are  not
employees of the Company will receive this 10,000 share option in
addition  to  the  ongoing 15,000 share option  described  above.
Like  the 15,000 share option, the exercise price of the  options
will  be set at the fair market value of the Common Stock on  the
date of grant.

<PAGE> 48

       ITEM 12.  SECURITY OWNERSHIP OF CERTAIN BENEFICIAL
       --------------------------------------------------
                      OWNERS AND MANAGEMENT
                      ---------------------

The following table sets forth the number of shares of Common
Stock and percentage of outstanding shares of Common Stock of the
Company owned as of April 1, 2000, by persons who hold of record
or are known to beneficially own 5% or more of the outstanding
common stock of the Company, each nominee and director of the
Company, the Named Persons and all officers, key employees and
directors as a group.
<TABLE>
<CAPTION>
<S> <C>                     <C>                   <C>

Name and Address of         Amount and Nature      Percent of
Beneficial Owner              of Beneficial           Class
                                Ownership
-------------------         -----------------      -----------
Paul C. Ahrens                  1,328,491              9.3%
1290 Industrial Way
Albany, OR

M. ("Sreeni") Sreenivasan         619,018(1)           4.3%(2)

Howard L. Farkas                  109,000(3)             *

Edward M. Giles                   277,000(4)           1.9%(2)

Page E. Golsan, III                51,000(5)             *

Donald M. Kuhla, Ph.D.             20,000(6)             *

Charles B. Williams               271,120(7)           1.9%(2)

Brown Capital Management        1,432,000(8)          10.0%
809 Cathedral Street
Baltimore, MD  21201

All Officers, Key               2,729,379(9)          18.6%(2)
Employees and Directors
as a Group (9 persons)

</TABLE>
______________________
*less than 1%.

(1)Includes  106,000 shares of common stock which Mr. Sreenivasan has the
   right to acquire immediately or within sixty (60) days pursuant to employee
   stock options.  Excludes 7,000 shares of common stock issuable pursuant to
   stock options held by Mr. Sreenivasan which are not exercisable now or within
   sixty (60) days.
(2)The denominator used in calculating the percentage is equal to the number
   of shares outstanding plus the number of shares the beneficial owner (or
   group of beneficial owners) has a right to acquire immediately or within
   sixty days pursuant to warrants or options.
(3)Includes  59,000 shares of common stock which Mr. Farkas has the right to
   acquire immediately or within  sixty  (60) days pursuant to stock options.
   Mr. Farkas disclaims ownership over 50,000 shares of common stock held in
   his name which have been pledged as security for a loan and over which
   Mr. Farkas has no voting  control.  Excludes 6,000 shares of common stock
   issuable pursuant to stock  options held by Mr. Farkas which are not
   exercisable now or within sixty (60) days.

<PAGE> 49

(4)Includes 16,000 shares of common stock which Mr. Giles hasthe right to
   acquire immediately or within sixty (60) days pursuant to stock options.
   Excludes 9,000 shares of common stock issuable pursuant to stock options
   held by Mr. Giles which are not exercisable now or within sixty (60) days.
   Also includes 60,000 shares of common stock held by two individuals who
   have granted to Mr. Giles the investment powers associated with these
   shares.
   Mr. Giles disclaims beneficial ownership over these 60,000 shares.
(5)Includes 9,000 shares of common stock which Mr. Golsan has the
   right to acquire immediately or within sixty (60) days pursuant to stock
   options.   Excludes 6,000 shares of common stock issuable pursuant to stock
   options held by Mr. Golsan which are not exercisable now or within sixty (60)
   days.
(6)Includes 16,000 shares of common stock which Dr. Kuhla has the right to
   acquire immediately or within sixty (60) days pursuant to stock  options.
   Excludes 9,000  shares of common stock issuable pursuant to stock options
   held by Dr. Kuhla which are not exercisable now or within sixty (60) days.
(7)Includes 78,000 shares of common stock which Mr. Williams has the right to
   acquire immediately or within sixty (60) days pursuant to employee stock
   options.  Excludes 7,000  shares  of common stock issuable pursuant to
   stock options  held  by  Mr.Williams  which are not exercisable now or
   within  sixty (60) days.
(8)Based on Schedule 13(g) filings, pursuant to which Brown Capital Management
   disclosed controlling 1,432,000 shares of common stock  with sole dispositive
   power.  Of these shares, Brown  Capital Management further disclosed that
   it had sole voting power over 1,333,700 shares of common stock.
(9)See footnotes 1, 3, 4, 5, 6 and 7.


           ITEM 13.  CERTAIN RELATIONSHIPS AND RELATED
           -------------------------------------------
                          TRANSACTIONS
                          ------------
Not applicable.

                             PART IV
                             -------

      ITEM 14.  EXHIBITS, FINANCIAL STATEMENT SCHEDULES AND
      -----------------------------------------------------
                       REPORTS ON FORM 8-K
                       -------------------

(a)(1)  and  (2)  FINANCIAL STATEMENTS  AND  FINANCIAL  STATEMENT SCHEDULES.

The information required by this item is included under Item 8 of this Report.

(a)(3)    EXHIBITS.

The following documents are filed as part of this Annual Report on Form 10-K:

3(i)1       Articles   of  Incorporation  of  Synthetech,  Inc.,   as
            amended.

3(ii)(6)    Bylaws of Synthetech, Inc., as amended.

4(7)        Synthetech,  Inc.  and American Securities  Transfer  and
            Trust, Inc. Rights Agent, Rights Agreement dated July 23,
            1998.

<PAGE> 50

10.1(2),(3) Supply   Agreement   dated  January   3,   1989   between
            Synthetech, Inc. and Biomeasure, Incorporated.

10.2(2),(3) License   Agreement  dated  January   3,   1989   between
            Synthetech, Inc. and Biomeasure, Incorporated.

10.3(4)+    Synthetech, Inc. 1990 Stock Option Plan.

10.4(5)     Amendment  No. 1 to Stock and Warrant Purchase  Agreement
            between the Company and JB dated as of March 26, 1996.

10.5(6)     1995 Incentive Compensation Plan, as amended.

10.6(8)     Promissory  Note  dated August 26, 1998 from  Synthetech,
            Inc. to United States National Bank of Oregon.

10.7(8)     Letter   Agreement   dated  August   26,   1998   between
            Synthetech,  Inc.  and  United States  National  Bank  of
            Oregon.

10.8(6)     Nonqualified Stock Option dated as of November 7, 1996 to
            purchase  50,000 shares of Common Stock issued to  Howard
            L. Farkas.

10.9(6)     Nonqualified Stock Option dated as of November 7, 1996 to
            purchase  15,000 shares of Common Stock issued to  Howard
            L. Farkas.

10.10()6    Nonqualified Stock Option dated as of November 7, 1996 to
            purchase 15,000 shares of Common Stock issued to Page  E.
            Golsan III.

10.11(6)+   Form  of  contract entered into by each of Mr. Philip  L.
            Knutson,  Mr. M. Sreenivasan and Mr. Charles B.  Williams
            dated July 18, 1997.

10.12(8)+   Bonus for M. Sreenivasan granted October 1, 1998.

10.13(8)    Contract  entered  into  by  Synthetech,  Inc.  and  R.L.
            Reimers Company dated December 1, 1998.

10.14       Form  of  Purchase  Order  and Schedule  of  Vendors  and
            Purchase Order terms.

10.15       Contracts  entered  into  between  Synthetech,  Inc.  and
            Olsson  Industrial Electric, Inc. October  13,  1998  and
            March 5, 1999.

23          Consent of Arthur Andersen LLP.

27          Financial Data Schedule for Twelve Months Ended March 31,
            2000.

<PAGE> 51
__________________________

+   Management contract or compensatory plan.

(1) Incorporated  by  reference  to  the  exhibits   filed   with
    registrant's Annual Report on Form 10-K for the fiscal year ended
    March 31, 1991.

(2) Incorporated  by  reference  to  the  exhibits   filed   with
    registrant's Annual Report on Form 10-K for the fiscal year ended
    March 31, 1990.

(3) Confidential treatment of certain portions of this document was
    granted  by  the  Commission on January 10, 1990  (File  No.  33-
    27566).

(4) Incorporated by reference to Exhibit A to the definitive  copy
    of registrant's Proxy Statement (dated October 23, 1990) for the
    1990 Annual Meeting of Shareholders.

(5) Incorporated  by  reference  to  the  exhibits   filed   with
    registrant's  Annual Report on Form 10-KSB for  the  fiscal  year
    ended March 31, 1996.

(6) Incorporated  by  reference  to  the  exhibits   filed   with
    registrant's  Annual Report on Form 10-KSB for  the  fiscal  year
    ended March 31, 1997.

(7) Incorporated   by   reference  to  the   exhibits   filed   with
    registrant's   Current  Report  on  Form   8-K   for   July   24,
    1998.

(8) Incorporated  by  reference  to  the  exhibits  filed  with
    registrant's Annual Report on Form 10-K for the fiscal year ended
    March 31, 1999.

(b) Reports on Form 8-K

    None.

(c) See (a) (3) above.

(d) See (a) (1) and (2) above.


<PAGE> 52




                           SIGNATURES
                           ----------

Pursuant  to  the  requirements of Section 13  or  15(d)  of  the
Securities  Exchange Act of 1934, the Registrant has duly  caused
this  Report  to  be  signed on its behalf  by  the  undersigned,
thereunto duly authorized.

Date:  June 5, 2000           SYNTHETECH, INC.
                               (Registrant)

                               By /s/ M. ("Sreeni") Sreenivasan
                                  -----------------------------
                                  M. ("Sreeni") Sreenivasan
                                  President and Chief
                                  Executive Officer

Pursuant  to the requirements of the Securities Exchange  Act  of
1934,  this Report has been signed below by the following persons
on  behalf  of the Registrant and in the capacities  and  on  the
dates indicated.

<TABLE>
<CAPTION>
<S><C>                           <C>                             <C>

     Signature                             Title                      Date
     ---------                             -----                      ----
/s/ M. ("Sreeni") Sreenivasan    President, Chief Executive       June 5, 2000
-----------------------------    Officer (Prinicpal Executive
    M. ("Sreeni") Sreenivasan    Officer) and Director


/s/ Charles B. Williams          Vice President of Finance and    June 5, 2000
-----------------------          Administration, Chief Financial
    Charles B. Williams          Officer, Secretary, Treasurer
                                 (Principal Financial Officer
                                 and Principal Accounting
                                 Officer), and Director

/s/ Paul C. Ahrens               Chairman of the Board            June 5, 2000
------------------
    Paul C. Ahrens

/s/ Howard L. Farkas             Director                         June 5, 2000
--------------------
    Howard L. Farkas

/s/ Edward M. Giles              Director                         June 5, 2000
-------------------
    Edward M. Giles

/s/ Page E. Golsan, III          Director                         June 5, 2000
-----------------------
    Page E. Golsan, III

/s/                              Director
--------------------------
    Donald M. Kuhla, Ph.D.

</TABLE>
<PAGE> 53

                             INDEX TO EXHIBITS
                             -----------------
                                                          Sequential Page No.

3(i)(1)      Articles  of  Incorporation of Synthetech,
             Inc., as amended

3(ii)(6)     Bylaws of Synthetech, Inc., as amended

4(7)         Synthetech,  Inc.  and American Securities
             Transfer  and Trust, Inc. Rights Agent,
             Rights Agreement dated July 23, 1998.

10.1(2),(3)  Supply  Agreement dated  January  3,  1989
             between  Synthetech, Inc. and  Biomeasure,
             Incorporated.

10.2(2),(3)  License  Agreement dated January  3,  1989
             between  Synthetech, Inc. and  Biomeasure,
             Incorporated.

10.3(4)+     Synthetech, Inc. 1990 Stock Option Plan.

10.4(5)      Amendment  No.  1  to  Stock  and  Warrant
             Purchase Agreement between the Company and
             JB dated as of March 26, 1996.

10.5(6)      1995   Incentive  Compensation  Plan,   as
             amended.

10.6(8)      Promissory Note dated August 26, 1998 from
             Synthetech, Inc. to United States National
             Bank of Oregon.

10.7(8)      Letter  Agreement dated  August  26,  1998
             between Synthetech, Inc. and United States
             National Bank of Oregon.

10.8(6)      Nonqualified  Stock  Option  dated  as  of
             November   7,  1996  to  purchase   50,000
             shares of Common Stock issued to Howard L.
             Farkas.

10.9(6)      Nonqualified  Stock  Option  dated  as  of
             November 7, 1996 to purchase 15,000 shares
             of   Common  Stock  issued  to  Howard  L.
             Farkas.

10.10(6)     Nonqualified  Stock  Option  dated  as  of
             November 7, 1996 to purchase 15,000 shares
             of  Common Stock issued to Page E.  Golsan
             III.

10.11(6)+    Form  of contract entered into by each  of
             Mr.  Philip L. Knutson, Mr. M. Sreenivasan
             and Mr. Charles B. Williams dated July 18,
             1997.

10.12(8)+    Bonus    for   M.   Sreenivasan    granted
             October 1, 1998.

10.13(8)     Contract entered into by Synthetech,  Inc.
             and R.L. Reimers Company dated December 1,
             1998.

<PAGE> 54

10.14        Form  of  Purchase Order and  Schedule  of
             Vendors and Purchase Order terms.

10.15        Contracts entered into between Synthetech,
             Inc.  and Olsson Industrial Electric, Inc.
             October 13, 1998 and March 5, 1999.

23           Consent of Arthur Andersen LLP.

27           Financial Data Schedule for Twelve Months
             Ended March 31, 2000.

__________________________

+ Management contract or compensatory plan.

(1)   Incorporated  by  reference  to  the  exhibits   filed   with
      registrant's Annual Report on Form 10-K for the fiscal year ended
      March 31, 1991.

(2)   Incorporated  by  reference  to  the  exhibits   filed   with
      registrant's Annual Report on Form 10-K for the fiscal year ended
      March 31, 1990.

(3)   Confidential treatment of certain portions of this document was
      granted  by  the  Commission on January 10, 1990  (File  No.  33-
      27566).

(4)   Incorporated by reference to Exhibit A to the definitive  copy
      of  registrant's Proxy Statement (dated October 23, 1990) for the
      1990 Annual Meeting of Shareholders.

(5)   Incorporated  by  reference  to  the  exhibits   filed   with
      registrant's  Annual Report on Form 10-KSB for  the  fiscal  year
      ended March 31, 1996.

(6)   Incorporated  by  reference  to  the  exhibits   filed   with
      registrant's  Annual Report on Form 10-KSB for  the  fiscal  year
      ended March 31, 1997.

(7)   Incorporated  by  reference  to  the  exhibits   filed   with
      registrant's Current Report on Form 8-K for July 24, 1998.

(8)   Incorporated  by  reference  to  the  exhibits   filed   with
      registrant's Annual Report on Form 10-K for the fiscal year ended
      March 31, 1999.



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