MORGAN STANLEY GROUP INC /DE/
SC 13G/A, 1995-02-14
SECURITY BROKERS, DEALERS & FLOTATION COMPANIES
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                    SECURITIES AND EXCHANGE COMMISSION
                          WASHINGTON, D.C. 20549


                               SCHEDULE 13G

                 Under the Securities Exchange Act of 1934

                            (Amendment No. 1 )


                            INSITE VISION INC.
              ----------------------------------------------
                             (Name of Issuer)


                               Common Stock
              -----------------------------------------------
                      (Title of class of securities)


                                 457660108
              -----------------------------------------------
                              (CUSIP number)


Check the following box if a fee is being paid with this statement [ ] (A
fee is not required only if the filing person:  (1) has a previous
statement on file reporting beneficial ownership of more than five percent
of the class of securities described in Item 1; and (2) has filed no
amendment subsequent thereto reporting beneficial ownership of five percent
or less of such class.)  (See Rule 13d-7).


The remainder of this cover page shall be filled out for a reporting
person's initial filing on this form with respect to the subject class of
securities, and for any subsequent amendment containing information which
would alter the disclosures provided in a prior cover page.


The information required in the remainder of this cover page shall not be
deemed to be "filed" for the purpose of Section 18 of the Securities
Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of
that section of the Act but shall be subject to all other provisions of the
Act (however, see the notes).

<PAGE>

                               SCHEDULE 13G

     CUSIP No. 457660108                               PAGE 2 OF 9 PAGES

1.   NAME OF REPORTING PERSONS
     S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS
          Morgan Stanley Group Inc.
          IRS # 13-283-8891

2.   CHECK APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                  (a)  [ ]
                                                  (b)  [ ]

3.   SEC USE ONLY



4.   CITIZENSHIP OR PLACE OF ORGANIZATION
          The state of organization is Delaware.


NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH

     5.   SOLE VOTING POWER
               0


     6.   SHARED VOTING POWER
               445,405


     7.   SOLE DISPOSITIVE POWER
               0


     8.   SHARED DISPOSITIVE POWER
               445,405


9.   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
          445,405


10.  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*



11.  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
          4.92%


12.  TYPE OF REPORTING PERSON*
          IA, CO



                  * SEE INSTRUCTIONS BEFORE FILLING OUT !

<PAGE>

                               SCHEDULE 13G

     CUSIP No. 457660108                               PAGE 3 OF 9 PAGES

1.   NAME OF REPORTING PERSONS
     S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS
          Morgan Stanley & Co. Incorporated
          IRS # 13-265-5996

2.   CHECK APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                  (a)  [ ]
                                                  (b)  [ ]

3.   SEC USE ONLY



4.   CITIZENSHIP OR PLACE OF ORGANIZATION
          The state of organization is Delaware.


NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH

     5.   SOLE VOTING POWER
               0


     6.   SHARED VOTING POWER
               445,405


     7.   SOLE DISPOSITIVE POWER
               0


     8.   SHARED DISPOSITIVE POWER
               445,405


9.   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
          445,405


10.  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*



11.  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
          4.92%


12.  TYPE OF REPORTING PERSON*
          BD, CO



                  * SEE INSTRUCTIONS BEFORE FILLING OUT !

<PAGE>

CUSIP NO. 457660108                                    PAGE 4 OF 9 PAGES

Item 1(a)      Name of Issuer
               --------------

               Insite Vision Inc.

Item 1(b)      Address of issuer's principal executive offices
               -----------------------------------------------

               965 Atlantic Avenue
               Alemeda, California 94501


Item 2(a)      Name of person filing
               ---------------------

               (a)  Morgan Stanley Group Inc.
               (b)  Morgan Stanley & Co. Incorporated


Item 2(b)      Principal business office
               -------------------------

               (a)  1251 Avenue of the Americas
                    New York, New York 10020

               (b)  1251 Avenue of the Americas
                    New York, New York 10020


Item 2(c)      Citizenship
               -----------

               Incorporated by reference to Item 4 of the cover
               page pertaining to each reporting person.


Item 2(d)      Title of class of Securities
               ----------------------------

               Common Stock


Item 2(e)      Cusip No.
               ---------

               457660108


Item 3         (a)  Morgan Stanley Group Inc. is (e) an Investment
                    Adviser registered under section 203 of the
                    Investment Advisers Act of 1940.

               (b)  Morgan Stanley & Co. Incorporated is (a) a Broker-
                    Dealer registered under Section 15 of the
                    Securities Exchange Act of 1934.


Item 4         Ownership
               ---------

               Incorporated by reference to Items (5) - (9) and (11)
               of the cover page pertaining to each reporting person.

<PAGE>

CUSIP NO. 457660108                                    PAGE 5 OF 9 PAGES

Item 5         Ownership of 5 Percent or Less of a Class
               -----------------------------------------

               a) As of the date hereof Morgan Stanley Group Inc.
                  has ceased to be the beneficial owner of more than
                  five percent of the class of securities.

               b) As of the date hereof Morgan Stanley & Co.
                  Incorporated has ceased to be the beneficial owner
                  of more than five percent of the class of securities.


Item 6         Ownership of More than 5 percent on Behalf of Another Person
               ------------------------------------------------------------

               Accounts managed on a discretionary basis by Morgan Stanley
               & Co. Incorporated, a wholly owned subsidiary of Morgan
               Stanley Group Inc., are known to have the right to receive
               or the power to direct the receipt of dividends from, or
               the proceeds from, the sale of such securities.  No such
               account holds more than 5 percent of the class.


Item 7         Identification and Classification of the Subsidiary Which
               Acquired the Security Being Reported on By the Parent
               Holding Company
               ------------------------------------------------------------

               Inapplicable


Item 8         Identification and Classification of Members of the Group
               ---------------------------------------------------------

               Inapplicable


Item 9         Notice of Dissolution of Group
               ------------------------------

               Inapplicable


Item 10        Certification
               -------------

               By signing below I certify that, to the best of my knowledge
               and belief, the securities referred to above were acquired
               in the ordinary course of business and were not acquired
               for the purpose of and do not have the effect of changing or
               influencing the control of the issuer of such securities and
               were not acquired in connection with or as a participant in
               any transaction having such purpose or effect.

<PAGE>

CUSIP NO. 457660108                                    PAGE 6 OF 9 PAGES

               After reasonable inquiry and to the best of my knowledge and
               belief, I certify that the information set forth in this
               statement is true, complete and correct.



               Date:          February 14, 1995

               Signature:     /s/ Edward J. Johnsen
                              ------------------------------------------
               Name/Title:    Edward J. Johnsen / Vice President
                              Morgan Stanley & Co. Incorporated
                              ----------------------------------------
                              MORGAN STANLEY GROUP INC.



               Date:          February 14, 1995

               Signature:     /s/ Edward J. Johnsen
                              -------------------------------------------
               Name/Title:    Edward J. Johnsen / Vice President
                              Morgan Stanley & Co. Incorporated
                              -----------------------------------------
                              MORGAN STANLEY & CO. INCORPORATED



                    INDEX TO EXHIBITS                            PAGE
                    -----------------                            ----
EXHIBIT 1      Agreement to Make a Joint Filing.                  7

EXHIBIT 2      Secretary's Certificate Authorizing Edward J.
               Johnsen to Sign on Behalf of Morgan Stanley Group
               Inc.                                               8

EXHIBIT 3      Secretary's Certificate Authorizing Edward J.
               Johnsen to Sign on behalf of Morgan Stanley & Co.
               Incorporated.                                      9

<PAGE>




CUSIP NO. 457660108                                    PAGE 7 OF 9 PAGES

                         EXHIBIT 1 TO SCHEDULE 13G

                             February 14, 1995


     MORGAN STANLEY GROUP INC. and MORGAN STANLEY & CO. INCORPORATED hereby
agree that, unless differentiated, this Schedule 13G is filed on behalf of
each of the parties.



BY:       /s/ Edward J. Johnsen
          ------------------------------------------
          Morgan Stanley Group Inc.
          Edward J. Johnsen / Vice President
          Morgan Stanley & Co. Incorporated



BY:       /s/ Edward J. Johnsen
          ------------------------------------------
          Morgan Stanley & Co. Incorporated
          Edward J. Johnsen / Vice President
          Morgan Stanley & Co. Incorporated




<PAGE>


CUSIP NO. 457660108                                    PAGE 8 OF 9 PAGES

                                 EXHIBIT 2
                          SECRETARY'S CERTIFICATE

     I, Patricia A. Kurtz, a duly elected and acting Assistant Secretary of

Morgan Stanley Group Inc., a corporation organized and existing under the

laws of the State of Delaware (the "Corporation"), certify that the

following resolutions were duly and validly adopted by the Executive

Committee of the Corporation by a Consent in Lieu of Meeting dated as

of September 8, 1993 and that such resolutions are in full force and effect

on the date hereof:


          RESOLVED, that the resolutions approved on April 23, 1991 in
     connection with the authorization of a specific individual to
     sign certain reports to be filed with the Securities and Exchange
     Commission ("SEC") are superseded by this resolution, and each of
     the following persons are authorized and directed to sign on
     behalf of the Corporation any reports to be filed under Section
     13 of the Securities Exchange Act of 1934, as amended, and the
     rules and regulations thereunder with the SEC, such
     authorizations to cease automatically upon termination of their
     employment with Morgan Stanley & Co. Incorporated:

                         Florence A. Davis
                         Edward J. Johnsen

     ; and

          RESOLVED FURTHER, that any actions heretofore taken by
     Florence A. Davis or Edward J. Johnsen in connection with the
     responsibilities noted in the preceding resolution are confirmed,
     approved and ratified.


     IN WITNESS WHEREOF, I have hereunto set my name and affixed the seal

of the Corporation as of the 7th day of December, 1993.



                                   /s/ Patricia A. Kurtz
                                   -------------------------------
                                   Patricia A. Kurtz
                                   Assistant Secretary
[SEAL]




<PAGE>


CUSIP NO. 457660108                                    PAGE 9 OF 9 PAGES

                                 EXHIBIT 3

                          SECRETARY'S CERTIFICATE
     I, Patricia A. Kurtz, the duly elected and acting Assistant Secretary

of Morgan Stanley & Co. Incorporated, a corporation organized and existing

under the laws of the State of Delaware (the "Corporation"), certify that

the following resolutions were duly and validly adopted by the

Administration Committee of the Board of Directors of the Corporation by a

Consent in Lieu of a Meeting dated September 16, 1993 and that such

resolutions are in full force and effect on the date hereof:


          RESOLVED, that Florence A. Davis and Edward J. Johnsen are
     severally authorized and directed to sign on behalf of the Corporation
     any reports to be filed under Section 13 of the Securities Exchange
     Act of 1934, as amended, and the rules and regulations thereunder with
     the Securities and Exchange Commission, such authorizations to cease
     automatically upon termination of employment with the Corporation or
     any of its affiliates; and

          RESOLVED FURTHER, that any actions heretofore taken by Florence
     A. Davis and Edward J. Johnsen in connection with the responsibilities
     noted in the preceding resolution are ratified, approved and
     confirmed.

          RESOLVED, that any and all actions to be taken, caused to be
     taken or heretofore taken by any officer of the Corporation in
     executing any and all documents, agreements and instruments and in
     taking any and all steps (including the payment of all expenses)
     deemed by such officer as necessary or desirable to carry out the
     intent and purposes of the foregoing resolutions are authorized,
     ratified and confirmed.

          IN WITNESS WHEREOF, I have hereunto set my name and affixed the

seal of the Corporation as of the 21st day of September 1993.




                                   /s/ Patricia A. Kurtz
                                   --------------------------------
                                   Patricia A. Kurtz
[SEAL]                             Assistant Secretary





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