EPITOPE INC/OR/
10-K405, 1997-12-29
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549
                                  ------------

                                    FORM 10-K
        (Mark one)

        [X] Annual  report  pursuant  to  Section 13 or 15(d) of the  Securities
Exchange Act of 1934 for the fiscal year ended September 30, 1997
                                       OR
        [ ] Transition  report pursuant to Section 13 or 15(d) of the Securities
Exchange Act of 1934 for the transition period from -------- to --------

                           Commission File No. 1-10492

                                  EPITOPE, INC.

             (Exact name of registrant as specified in its charter)

                 Oregon                                  93-0779127
     (State or other jurisdiction of        (I.R.S. employer identification no.)
     incorporation or organization)

        8505 S.W. Creekside Place
           Beaverton, Oregon                                97008
(Address of principal executive offices)                 (Zip code)
                                 (503) 641-6115
              (Registrant's telephone number, including area code)

        Securities registered pursuant to Section 12(b) of the Act: None
          Securities registered pursuant to Section 12 (g) of the Act:

                           Common Stock, no par value
                                (Title of Class)

                         Preferred Stock Purchase Rights
                                (Title of Class)

        Indicate by check mark whether the  registrant (1) has filed all reports
required to be filed by Section 13 or 15(d) of the  Securities  Exchange  Act of
1934  during  the  preceding  12 months  (or for such  shorter  period  that the
registrant was required to file such reports),  and (2) has been subject to such
filing requirements for the past 90 days. Yes [X] No [ ]

        Indicate by check mark if disclosure of  delinquent  filers  pursuant to
Item 405 of Regulation S-K is not contained  herein,  and will not be contained,
to the best of  registrant's  knowledge,  in  definitive  proxy  or  information
statements  incorporated  by  reference  in Part  III of this  Form  10-K or any
amendment to this Form 10-K. [X]

        State the  aggregate  market value of the voting and  non-voting  common
equity  held by  non-affiliates  of the  registrant,  as of  December  1,  1997:
$65,757,368

      Indicate the number of shares outstanding of each of the registrant's
classes of common stock,  as of December 1, 1997:  Common  Stock,  no par value,
13,454,330 shares.

                      Documents Incorporated by Reference:

Definitive Proxy Statement for 1998 Annual Shareholders' Meeting:  Part III


<PAGE>

                               Table of Contents

                                     PART I
                                                                            Page

ITEM 1.         Business                                                       3

ITEM 2.         Properties                                                    14

ITEM 3.         Legal Proceedings                                             14

ITEM 4.         Submission of Matters to a Vote of Security Holders           14


                                     PART II


ITEM 5.         Market  for   Registrant's   Common   Equity  and   Related
                Stockholder Matters                                           15

ITEM 6.         Selected Financial Data                                       16

ITEM 7.         Management's Discussion and Analysis of Financial Condition
                and Results of Operations                                     17

ITEM 7A.        Quantitative and Qualitative Disclosures About Market Risk    20

ITEM 8.         Financial Statements and Supplementary Data                   21

ITEM 9.         Changes in and Disagreements with Accountants on Accounting
                and Financial Disclosure                                      21


                                  PART III

ITEM 10.        Directors and Executive Officers of the Registrant            22

ITEM 11.        Executive Compensation                                        22

ITEM 12.        Security   Ownership  of  Certain   Beneficial  Owners  and
                Management                                                    22

ITEM 13.        Certain Relationships and Related Transactions                22


                                  PART IV


ITEM 14.        Exhibits, Financial Statement Schedules, and Reports on
                Form 8-K                                                      22


<PAGE>


                                     PART I

ITEM 1. BUSINESS

Epitope, Inc. (Epitope or the Company), is an Oregon corporation incorporated in
1981.  Epitope  develops and markets oral specimen  collection  kits and related
diagnostic  tests for the detection of the Human  Immunodeficiency  Virus (HIV),
the cause of Acquired Immune Deficiency  Syndrome (AIDS),  and for the detection
of other medical conditions and analytes.  Epitope's lead product,  the patented
OraSure(R)  collection  device,  is used as part of an oral specimen  diagnostic
system. The Company markets the device under the brand name EpiScreen(TM) in the
United States for use in screening  life  insurance  applicants,  and in certain
foreign  countries  for use in  professional  markets.  In the  balance  of this
document the product will be referred to only as OraSure.

The OraSure  device  consists of a small,  treated  cotton-fiber  pad on a nylon
handle  that is  placed  in the  patient's  mouth for two  minutes.  The  device
collects oral mucosal  transudate  (OMT),  a  serum-derived  fluid that,  unlike
saliva, contains higher concentrations of HIV antibodies in people infected with
the virus.  As a result,  OMT testing is a highly  accurate method for detecting
HIV  infection.  Because  OraSure  uses a  noninvasive,  needle-free  collection
method,  the Company  believes that oral fluid  testing has several  significant
advantages over  blood-based  testing systems for both healthcare  professionals
and patients.

Epitope also markets HIV-1 Western blot  confirmatory  test kits used to confirm
positive  results of initial  screening tests for HIV-1  infection.  Its OraSure
HIV-1  Western  blot   confirmatory   test  kit  is  used  in  conjunction  with
oral-specimen  based screening  tests,  while its EPIblot(R)  HIV-1 Western blot
confirmatory  test kit is used in conjunction with blood-based  screening tests.
The kits are  distributed  worldwide  under an exclusive  agreement with Organon
Teknika Corporation (Organon Teknika), a member of the Akzo Pharma group of Akzo
Nobel, NV. , an international chemical and pharmaceutical  manufacturer based in
Arnhem, The Netherlands.

The OraSure HIV-1 Oral Specimen  Collection device and the OraSure HIV-1 Western
blot and EPIblot  confirmatory  tests have all received  clearance from the U.S.
Food and Drug  Administration  (FDA)  for sale to  professional  markets  in the
United States.

In February  1995, the Company  entered into a  Development,  License and Supply
Agreement (the SB Agreement)  with SmithKline  Beecham plc (SB),  under which SB
would market the OraSure  device on an  exclusive  basis in the U.S. and certain
foreign countries as part of an integrated test system to physicians,  hospitals
and other healthcare professionals. The parties terminated the agreement in July
1997.  As a result,  the Company  may now sell the  OraSure  directly or through
other distributors to markets previously reserved to SB under the SB Agreement.

During fiscal 1997,  Agritope,  Inc. (Agritope) was a wholly owned subsidiary of
Epitope.  Agritope is a biotechnology company specializing in the development of
new fruit and vegetable plant varieties for sale to the fresh produce  industry.
Epitope  expects to make a  distribution  of all of its  ownership  interest  in
Agritope to Epitope's  shareholders  (the  Agritope  Spin-off) in late  December
1997. Following the Agritope spin-off, Epitope will no longer own or control any
shares of Agritope stock.

BACKGROUND

Acquired   Immune   Deficiency   Syndrome   (AIDS)   is   caused  by  the  Human
Immunodeficiency  Virus.  HIV attacks the immune  system,  slowly  weakening the
body's  ability to ward off infection  and certain  forms of cancer.  When these
complications  develop, the HIV infection has progressed to clinically diagnosed
AIDS. HIV is spread through sexual contact,  blood transfusions,  the sharing of
intravenous  needles,  accidental needle sticks, or contact between a mother and
her child during gestation, childbirth, or breast-feeding. There is currently no
known cure for  HIV/AIDS.  However,  the recent  introduction  of a new class of
anti-HIV  drugs  called  protease  inhibitors,  when  used in  combination  with
nucleoside  analogs (e.g., AZT), has shown promising results in slowing progress
of the disease.  Clinical studies have demonstrated that the early detection and
treatment  of HIV can help to curb the effects of the disease and  significantly
prolong the life of the patient.  Other studies have shown that  treatment  with
AZT of an HIV-infected  pregnant woman may prevent the  transmission of HIV from
the mother to her child.


                                      - 3 -
<PAGE>


According to the United Nations  Program on HIV/AIDS,  an estimated 30.6 million
people  worldwide are now living with HIV, the virus that causes AIDS. Data from
1997 show that the previous estimates of HIV transmission grossly underestimated
the spread of the AIDS virus.  The U.N. now  believes  that new  infections  are
occurring  almost twice as fast as they  estimated a year ago.  Instead of 8,200
new  infections a day, the U.N.  now  believes  that there are 16,000.  In North
America,  an estimated 860,000 people have been infected with HIV. For children,
the  report  estimates  that  1,600  under 15 years  old are  infected  each day
compared to 1,000 per day a year ago.

Based on industry estimates, the Company believes that approximately 100 million
HIV tests were  performed in the U.S. in 1996,  with blood banks  accounting for
about 25 million.  The Company  feels that a large  proportion  of the non-blood
bank HIV testing  market should be available to OraSure  because of the accuracy
of the test and the  benefits of not having to draw blood.  Currently,  most HIV
tests are  performed by testing a patient's  blood.  There are a number of blood
tests for HIV, the most common of which is the enzyme-linked immunosorbent assay
(ELISA or EIA). In order to reduce the  possibility  that an individual  without
HIV  will  be   diagnosed  as  having  the  virus  (a  false   positive),   most
industrialized  countries  require the  retesting  of the blood  sample  using a
second,  more specific test to confirm an initial positive test result. The most
commonly used confirmatory test is the Western blot.

The Company believes that blood-based  testing,  in a situation other than blood
donation,  has a number of  disadvantages  which increase  healthcare  costs and
patient inconvenience,  pose a risk of infection to healthcare professionals and
make testing uneconomic or unavailable in certain applications or settings,  and
that the OraSure product  overcomes these problems.  The  disadvantages of blood
testing include:

Risk of HIV  Infection.  Blood  tests  involve  the use of needles or lancets to
obtain blood from the patient.  Healthcare  professionals  collecting blood risk
contracting  HIV if  accidentally  stuck by the needle or lancet  used to obtain
blood from an infected patient.

Limited Access.  Because blood must be collected by trained  professionals,  its
collection is often difficult or  prohibitively  expensive in certain  settings.
For  example,   community-based  outreach  programs,  homeless  shelters,  rural
communities,  and other  remote  settings  often lack  healthcare  professionals
trained in blood  collection.  As a result,  blood testing may not be as readily
available in some of these settings.

Higher  Overall  Cost.  The cost of  collecting  a blood  specimen  represents a
significant  component  of the total cost of HIV  testing.  Furthermore,  when a
healthcare professional must travel to the subject's office or home to collect a
blood sample, as is often the case with life insurance  applicant  testing,  the
cost of collecting the blood specimen is substantially increased.

Patient  Discomfort.  Blood tests require the use of needles or lancets that are
uncomfortable for patients.  In addition,  patients with small or damaged veins,
such as  intravenous  drug users,  the elderly and young  children,  may require
multiple needle sticks in order to obtain an adequate blood sample.

EPITOPE ORAL SPECIMEN COLLECTION TECHNOLOGY

In order to address the significant drawbacks associated with blood-based tests,
Epitope  developed and patented a device to collect an oral specimen  instead of
blood.  The  OraSure  device,  shaped  like a small  toothbrush,  consists  of a
cotton-fiber  pad treated with a proprietary  salt  solution.  The pad, which is
mounted on a nylon handle,  is placed in the  patient's  mouth between the lower
cheek and gum for two minutes.  The pad  collects  oral  mucosal  transudate,  a
serum-derived  fluid that,  unlike saliva,  contains  higher  concentrations  of
antibodies. OMT contains approximately four times the amount of antibodies found
in ordinary whole saliva. Following collection,  the pad is sealed in a specimen
vial containing a proprietary  preservative  solution.  The treated pad enhances
the collection,  and the preservative  solution enhances the  stabilization,  of
antibodies and other analytes originating from the oral mucosae. The specimen in
the vial is stable for three weeks at room  temperature,  although in most cases
laboratory testing takes place within one to three days.


                                      - 4 -
<PAGE>


PRODUCTS

OraSure.  In December 1994, the Company received  clearance from the FDA to sell
OraSure to professional markets for the ELISA screening of HIV-1 antibodies. The
device is marketed  directly by the Company  under the trade name  EpiScreen for
use by the U.S. life insurance  industry and in certain  international  markets,
and under the trade  name  OraSure  to  healthcare  professionals  in the United
States and a number of other countries. See "Marketing."

The  OraSure  oral  specimen  collection  and  HIV-1  testing  system  is easily
administered  and involves three steps: (i) collection of an oral specimen using
the OraSure  collection  device,  (ii) ELISA  screening  of the specimen for HIV
antibodies  at a  laboratory,  and (iii)  laboratory  confirmation  of  positive
screening test results with the FDA-cleared  OraSure Western blot kit. A trained
healthcare  professional  then conveys  test  results and  provides  appropriate
counseling to the patient.

The OraSure HIV-1 testing  system  represents a highly  accurate  alternative to
traditional  blood-based tests. In clinical trials, OraSure provided the correct
result or triggered  appropriate  follow-up  testing in 3,569 out of 3,570 cases
(99.97  percent).  The Company  believes  OraSure has  several  advantages  over
blood-based tests, as outlined in the following table.

Feature        Blood Test                            EpiScreen/OraSure

Safety         Poses risk of HIV                     Eliminates risk of
               infection through                     needle-stick accidents
               accidental needle sticks

Invasiveness   Requires use of a                     Uses noninvasive
               needle or lancet                      collection technique

Ease of use    Requires blood                        Sample collection
               collection by a                       requires minimal
               trained healthcare                    training
               professional

Portability    Generally performed in                Can be used rapidly and
               a physician's office                  efficiently in almost
               or other healthcare                   any setting
               setting

Cost           Requires a nurse or                   Eliminates the need for
               other trained healthcare              and costs associated
               professional                          with a trained
                                                     healthcare professional

Oral-based and Serum-based  Western Blot  Confirmatory  Tests.  Epitope has also
developed,  and in June 1996  received FDA  clearance to market,  an  oral-based
HIV-1 Western blot confirmatory  test. This test uses the original oral specimen
to confirm  positive  results of initial  OraSure HIV-1 ELISA  screening  tests.
Epitope has also marketed EPIblot, a serum-based Western blot HIV-1 confirmatory
test kit, since 1987. The kit is used to confirm the positive results of initial
blood-based screening tests for HIV-1 infection.


                                      - 5 -
<PAGE>


MARKETS

Life Insurance  Industry.  Epitope  believes there is a significant  need in the
life   insurance   industry   for   an   easy-to-administer,   noninvasive   and
cost-effective  HIV  testing  system  such as  OraSure.  In the  United  States,
approximately  4.5  million  HIV  tests  were  administered  in 1996 by the life
insurance industry in connection with the issuance of new policies. In addition,
data from the  American  Council  of Life  Insurance  and the  Health  Insurance
Association  of America  indicate that over $1.5 billion in  AIDS-related  death
benefits  were paid in 1995.  The  organizations  also  cautioned  that,  due to
difficulty in identifying all AIDS-related  claims,  the data may  significantly
understate the financial impact of AIDS on the insurance industry.

Traditional  HIV  testing of life  insurance  applicants  involves  the use of a
paramedic or other trained healthcare professional to obtain a blood sample. The
cost to the insurance company for an HIV test includes the cost of the paramedic
as well as the cost of the collection kit and laboratory testing services. These
costs  range from  approximately  $55 to $70, of which $35 to $50 is the cost of
the paramedic.  As a result,  insurance  companies  have  generally  limited HIV
testing to policies  with face  amounts of  $100,000 or more.  Based on industry
statistics, Epitope estimates that in 1994 approximately 9 million policies were
issued for face amounts of less than  $100,000,  representing  66 percent of all
policies issued.  The Company believes that the use of OraSure can significantly
reduce the cost of HIV testing to the insurance  industry because  collection of
an oral fluid  specimen can be performed  by insurance  agents or other  persons
without professional medical training, eliminating the cost of the paramedic and
making  testing  at policy  levels  below  $100,000 a  cost-effective  practice.
Moreover,  the  Company has found that some  insurance  companies  are  adopting
OraSure for use in connection with applications for insurance policies with face
amounts at and above $100,000 because the tests for HIV-1,  cocaine and cotinine
give them sufficient information. John Hancock Mutual Life Insurance, one of the
nation's largest life insurers, is now using OraSure to test applicants 40 years
old and under for  policies  up to but not  including  $1  million,  citing  the
elimination  of the  unpleasant  blood and urine tests and other  medical  exams
required for underwriting purposes.

Epitope also believes that the use of OraSure will allow the insurance  industry
to address "anti-selection."  Anti-selection occurs when an individual who knows
that he or she is infected with HIV  intentionally  applies for one or more life
insurance policies that do not entail HIV testing. The Company believes that the
adoption of OraSure by a number of insurance companies,  and the availability of
a recently  approved  over-the-counter  (OTC) HIV blood test,  may  increase the
incidence of anti-selection. By allowing insurance companies to lower the policy
level at which HIV  testing  is  cost-effective,  the use of  OraSure  may allow
insurance  companies to reduce their exposure to losses from  anti-selection and
thereby to lower overall claims costs.

An additional  advantage of the OraSure testing system is that the oral specimen
used for HIV testing can also be used to identify  smokers and users of cocaine.
Cotinine,  a metabolite of nicotine,  can be detected using OraSure. The FDA has
advised  Epitope that OraSure may be used for cocaine testing for the purpose of
life insurance risk assessment while a 510(k) notice is undergoing final review,
and may be used for cotinine testing  generally.  In a presentation at the 105th
annual  meeting of The  American  Academy of  Insurance  Medicine,  a major life
insurance  company  reported results of the use of the OraSure testing system in
Canada and in the Bahamas from 1992 to 1995. The life insurance company reported
that agent collection  reduced its testing costs by $65 per application.  During
the  four-year  study  period,  the insurer  found that it saved $1.7 million by
using  OraSure for HIV and cocaine  testing.  In  addition,  the life  insurance
company  determined  that it realized  $1.6 million in  increased  premiums as a
result of identifying  smokers who claimed on their  applications that they were
nonsmokers.  In another  study  presented  to this same  Academy,  Crown Life of
Canada  reported  that the five year savings from testing for cocaine,  cotinine
and HIV were approximately $1.4 million.

Physician and Public Health  Clinical  Market.  The  physician  market  consists
primarily  of  individual  doctor's  offices  which  are  supplied  through  the
physician's supply house network.  Selling to this market requires a substantial
sales force to call on the many offices throughout the country,  each making its
own  purchasing   decision.   SB  was  marketing  to  these  customers   through
representatives  of the  physician  supply  network  and  advertising  in  trade
journals.  Since the termination of the SB Agreement,  Epitope has chosen not to
focus on this  highly  diverse  market at this time  because of the high cost of
selling to these customers.


                                      - 6 -
<PAGE>


The public health market is more concentrated  than the physician  market,  with
typically more purchasing power in each decision maker. The customers consist of
a broad range of clinics and laboratories such as states, counties, colleges and
universities,  prison  systems  and the  military.  There  are also a number  of
smaller  organizations  in this market such as AIDS  Service  Organizations  and
various  community  based  organizations  set  up for  the  primary  purpose  of
encouraging  and enabling HIV testing to combat the spread of AIDS.  The OraSure
device has received a warm welcome in much of this market because of its ease of
use and  reliability.  In some cases  there has been an issue of higher cost for
OraSure testing as compared to blood-based testing. This has been principally in
the smaller  organizations  or in customers  who are starting  with small volume
testing and therefore not achieving  volume price breaks for the OraSure  device
or the  related  tests.  In order to avoid  having  cost be a major  obstacle to
growth in volume and adoption of this new testing format,  Epitope is addressing
the issue on several fronts.  For example,  to assist in the cost of testing and
to provide fast turnaround with accurate test methods,  Epitope has entered into
an agreement with LabOne to provide a prepackaged  OraSure test kit with prepaid
testing  and sample  shipment  to LabOne via  overnight  express.  This  product
package  will be sold  directly to the public  health  customers  by the Epitope
sales force.

OTC Market. The over-the-counter (OTC) market for HIV testing currently consists
only of one test,  distributed  by Home Access  Health Care,  which uses a dried
blood  spot to  provide  the  patient's  sample.  This  sample is then sent to a
laboratory for testing and the test results are communicated to the customer via
an 800 number.  In July 1997,  citing  lower sales than  expected  and the lower
market  estimates,  Johnson & Johnson  dropped its Confide  product from the OTC
market.  Also in July 1997,  SB and Epitope  terminated  their  agreement.  As a
result,  Epitope has  significantly  reduced the  attention and resources it was
devoting  to  preparation  for the OTC market,  and has  shifted  instead to the
public health markets, including college health and corrections. The Company has
not  ruled  out an  eventual  move  into  the OTC  market,  but it is not a high
priority at this time.

International.  In light of the  worldwide  scope of the HIV  epidemic,  Epitope
believes   there  are   significant   opportunities   for  sale  of  OraSure  in
international  markets. The Company believes that the ease of use,  portability,
increased  safety and  aversion to blood draw in certain  cultures  will provide
significant  advantages over blood tests in international  markets.  Epitope has
initiated an international  marketing program that features direct assistance to
distributors in establishing  OraSure programs that include laboratory services,
cooperation  from  screening test  manufacturers,  and provision of Western blot
confirmatory  kits in each  country.  Epitope  is  currently  marketing  OraSure
directly to customers in Canada and through  distributors in the United Kingdom,
Thailand,  Argentina,  Brazil,  South Africa,  Greece, the Philippines,  Taiwan,
Mexico and Colombia. Epitope also has a joint venture in Japan.

PRODUCTS UNDER DEVELOPMENT

OraSure. Oral mucosal transudate (OMT) contains many constituents found in blood
serum.  Because of this  feature,  the  Company  believes  OraSure is a platform
technology with a wide variety of potential applications beyond HIV testing. For
example,  the  OraSure  device may be useful for the  diagnosis  of a variety of
infectious  diseases in addition to HIV, such as viral hepatitis and a number of
childhood  diseases.  In  addition,  the Company  believes  that the use of oral
specimens  may allow  physicians  to diagnose  diseases more readily in children
without  subjecting  them to the  discomfort of drawing a blood sample,  thereby
increasing the frequency of testing for diseases.

The  Company has  demonstrated  that the OraSure  device has  potential  for the
collection  of  samples  which can be tested  for  drugs of abuse  (NIDA-5)  and
cotinine,  a  derivative  of  nicotine.  Under an agreement  with  Epitope,  STC
Technologies,  Inc., has developed enzyme immunoassays (EIA's) for the detection
of cocaine,  methamphetamine,  cannabanoids (THC), opiates,  phencyclidine (PCP)
and cotinine present in oral specimens.  Four 510(k)  notifications for cocaine,
methamphetamines,  cannabanoids (THC) and cotinine are currently  undergoing FDA
review.  Additional 510(k)  notifications for opiates and PCP are expected to be
submitted within the next few months.  If approved,  these will allow Epitope to
market OraSure to professional markets for drug abuse detection,  in addition to
the life insurance industry. Although cotinine is not currently regulated by the
FDA for risk assessment,  the 510(k)  application for cotinine has been filed in
anticipation that cotinine testing for non-insurance  purposes will be performed
at some time in the  future.  Physicians  may also find the  device  useful  for
monitoring  level of drugs and hormones  that must be  maintained  within narrow
therapeutic ranges. Monitoring of these


                                      - 7 -
<PAGE>


substances   currently   requires   frequent   blood  tests  to  determine  drug
concentration.  The Company  believes that oral specimen testing would eliminate
the discomfort and inconvenience associated with this frequent blood testing.

OraQuick. Epitope is currently developing OraQuick(R), a one-step,  rapid-format
oral  specimen  testing  system  designed  to provide  test  results  within ten
minutes. The Company believes that OraQuick has significant potential as a rapid
test  for  professional  use,  and  as  an  OTC  home-based  test.  Epitope  has
substantially  completed  a prototype  of  OraQuick to test for HIV,  with other
tests in various  stages of  development.  Like OraSure,  OraQuick is a platform
technology with a variety of potential  applications in addition to HIV testing.
Modifications  of the basic  OraQuick  technology may allow use of this approach
for detection of antibodies  against the  ulcer-causing  bacterium  helicobacter
pylori, as well as for a variety of infectious diseases such as syphilis,  viral
hepatitis,  and childhood  infections.  The  application of this  technology for
drugs of abuse  testing  appears  possible  and is a high  priority  within  the
Epitope development group.

DNA Forensic Testing.  Epitope has conducted successful preliminary trials which
have shown that it is  possible  to collect an  excellent  DNA sample  using the
OraSure  device.  This sample is in addition to the antibody sample that is used
to test for HIV,  making it  possible to test for  antibodies  and produce a DNA
"fingerprint" with a single OraSure collection.  The Company has contracted with
a  well-established  firm,  experienced in the field of DNA testing,  to conduct
further tests.


MARKETING

Life Insurance Industry. Epitope currently markets its OraSure device for use in
screening life insurance applicants for HIV, cocaine, and nicotine.  The Company
maintains a three-member direct sales force that markets OraSure directly to the
insurance  companies.  The  insurance  companies  then make  their own  decision
regarding  which insurance  reference  laboratory to use to supply their devices
and testing service.  The major laboratories  currently using the OraSure device
include LabOne, Inc., Osborn Laboratories and Clinical Reference Laboratory.  As
of  November  1997,  24 of the  top  100,  and 6 of the  top 10  life  insurance
companies were using OraSure to varying degrees for testing  applicants for life
insurance. Currently there are 62 insurance companies using OraSure. Because the
insurance  companies  are in various  stages of their launch plans with OraSure,
there exists a wide range of policy  limits where the product is being  applied.
Some  insurance  companies  have chosen to extend their  testing to lower policy
limits where they did not test at all before,  while others have used OraSure to
replace  some of their  blood-based  testing.  The  Company's  sales focus is on
converting  additional  insurance companies to the use of OraSure, and extending
its use within the companies already using OraSure.

Physician and Public Health Clinical Market. Through September 1997, SB marketed
Epitope's  oral  HIV  testing  system  to  the  physician,  hospital  and  other
professional  healthcare  provider  markets  under the brand name  OraSure.  The
Company resumed direct marketing of the device to these markets in October 1997.
Information  about the product is  accessible  to consumers  through a toll-free
number (1-800-OraSure) and on the Internet (www.OraSure.com).  Epitope is in the
process of  determining  whether to merge the  OraSure web site into the Epitope
web  site  (www.Epitope.com).  The SB  product  launch  in  1996  and  1997  was
accompanied  by an  advertising  campaign  featuring  two-page  spreads in major
medical professional publications. The OraSure brand was also a major sponsor of
the 1996 AIDS  Candlelight  March in Washington,  D.C.,  conducted in connection
with the display of the National AIDS Quilts. In addition, SB sponsored numerous
AIDS testing  programs  through  various  public health  organizations,  further
increasing the awareness of OraSure in these  markets.  During the period of the
agreement  (from Feb 1995 to July 1997),  SB marketed and publicized the OraSure
brand name, and the benefits of oral specimen testing,  nationwide.  SB set up a
testing service for OraSure samples through its SB Clinical  Laboratories (SBCL)
division,  which  continues  to  operate  following  the  termination  of the SB
Agreement.  In addition,  SB initiated  customer  contacts,  and began the sales
process  in  the  public  health  arena  with a  dedicated  sales  force  making
significant  inroads  in this  market.  Epitope  has hired some of the key sales
personnel  from SB that had been focused on the public  health  market,  and has
begun selling its products directly to these customers.


                                      - 8 -
<PAGE>


OTC  Market.  In addition to the sales  efforts in the  professional  and public
health  markets,  substantial  work was put into  preparation  for launching the
OraSure  product  into the OTC market.  This market  would have  required an FDA
approved  testing  laboratory  (such as the one set up by  SBCL),  a  counseling
service to provide test results, advice and referrals to customers, and a system
which would insure accurate and reliable handling of information  related to the
customer  sample,  test results and  counseling  data.  Epitope and SB conducted
clinical  trials  which  demonstrated  that  ordinary  untrained  customers  can
reliably  use the OraSure  device to collect an adequate  sample for HIV testing
using only printed  instructions  supplied with the OraSure device.  Although SB
and Epitope have chosen not to pursue the OTC markets at this time,  Epitope has
begun discussions with other potential marketing partners.  Epitope continues to
believe that the benefits of oral  specimen  testing  would offer a  significant
advantage in a consumer  setting  because it helps to overcome the aversion many
people have to taking their own blood for a sample.

International.  Epitope markets to  international  customers  primarily  through
carefully  chosen  distributors  with  knowledge  of  their  local  market.  The
distributor's  expertise is supplemented by Epitope's  contacts with the testing
companies to assist in  registering  the necessary  tests in each  country,  and
Epitope's assistance with training and support materials.

Western  Blot  Distribution.  Epitope has entered  into supply and  distribution
agreements  with Organon  Teknika.  The supply  agreement  provides that Organon
Teknika  will  supply  the  HIV-1  antigen  used  to  manufacture  Western  blot
confirmatory  test kits. The  distribution  agreement grants Organon Teknika the
exclusive right to purchase Western blot confirmatory test kits from Epitope and
to market them  worldwide.  Epitope and Organon  Teknika  recently  extended the
expiration dates for the supply and distribution arrangements to March 31, 1998.

COMPETITION

Competition in the emerging market for HIV testing is intense and is expected to
increase.  The Company  believes that the principal  competition  will come from
existing  blood-based HIV assays and from urine-based testing assays.  Epitope's
competitors  include  specialized  biotechnology firms as well as pharmaceutical
companies with biotechnology divisions and medical diagnostic companies, many of
which have considerably  greater financial,  technical,  and marketing resources
than Epitope.  Competition may intensify as technological  advances are made and
become more widely  known and as products  reach the market in greater  numbers.
Furthermore,  new testing  methodologies  could be  developed in the future that
render  Epitope's  oral-based HIV test  impractical,  uneconomical  or obsolete.
There  can be no  assurance  that  Epitope's  competitors  will not  succeed  in
developing or marketing  technologies  and products that are more effective than
those  developed  by Epitope or that would render its  technologies  or products
obsolete or otherwise commercially  unattractive.  In addition,  there can be no
assurance that competitors will not succeed in obtaining regulatory approval for
these products,  or in introducing or commercializing them before Epitope.  Such
developments  could have a material  adverse  effect on the Company's  business,
financial condition and results of operations.

Three  companies  have  submitted  applications  to the FDA  for  OTC HIV  blood
testing:  Direct Access  Diagnostics,  Home Access  Health  Corp.,  and ChemTrak
Incorporated.  The FDA has approved home  collection  kits for HIV blood testing
developed by Direct  Access  Diagnostics  (Johnson & Johnson) and by Home Access
Health Corp. In July 1997 Johnson & Johnson  withdrew its HIV home test from the
market, citing weak sales.

Cambridge  Biotech  Corporation and BioRad  Laboratories,  Inc.  manufacture HIV
Western  blot  confirmatory  tests,  and  Waldheim  Pharmazeutika   manufactures
immunofluorescent  HIV confirmatory  tests, which compete with Epitope's EPIblot
HIV-1 Western blot serum-based confirmatory test kits.

Several other  companies  market or have announced plans to market oral specimen
collection  devices and tests outside the United States and have announced plans
to seek FDA  approval of such tests in the United  States.  Epitope  expects the
number of devices  competing with its OraSure device to increase as the benefits
of oral specimen-based  testing become more widely accepted. The Company expects
that  FDA  approval  of  the  OraSure  device  will  also  encourage   potential
competitors to develop oral diagnostic  products.  No such devices have yet been
approved by the FDA for HIV testing. See "Government Regulation".


                                      - 9 -
<PAGE>


The FDA has approved an HIV ELISA  screening  test for use with a urine  sample.
More recently the FDA notified  Cambridge Biotech Corp that it had completed the
review of its HIV-1 Western Blot  confirmatory  test for use with urine samples,
and that the  application  was  approvable,  pending the  completion  of product
labeling and restrictions on its use. Until a confirmatory  test for HIV testing
with urine is approved,  a patient who gives an initial positive urine screening
result  must  return  to give a  second,  blood-based  sample  for  confirmatory
testing.  The Company  believes that urine  collection can be logistically  more
difficult,  inconvenient and potentially  embarrassing for the patient, and that
privacy and  chain-of-custody  issues are further  impediments to routine use of
urine-based HIV tests.

GOVERNMENT REGULATION

General. Many of Epitope's proposed and existing diagnostic products are subject
to  regulation  by the FDA,  other  federal,  state,  and  local  agencies,  and
comparable  bodies in foreign  countries.  Such  regulation  governs  almost all
aspects of development and marketing,  including the introduction,  advertising,
promotion,  manufacturing practices, labeling,  distribution, and record keeping
for the products.  In the United States,  different types of diagnostic products
are regulated  differently  by the FDA, as discussed  below.  As part of the FDA
clearance  process,  Epitope often must  demonstrate  that its products are both
safe and effective for a particular indication or application.

Drugs and Biological Products.  Generally, drugs and biological products require
FDA approval  before  marketing.  The steps required before a drug or biological
product may be marketed in the United States include: (1) preclinical laboratory
and animal tests;  (2) submission of an application for an  investigational  new
drug or biological  product,  which must become  effective before human clinical
trials may commence;  (3) human  clinical  trials;  (4)  submission of a Product
License  Application (PLA) for the biological  product or a New Drug Application
(NDA) for most other new drug products; and (5) approval of the PLA or NDA.

Preclinical  safety  and  initial  efficacy  testing is  usually  undertaken  in
animals. Results of such preclinical and other laboratory tests are submitted to
the FDA before human clinical  trials can begin.  Clinical  trials are typically
conducted in three phases.  Phase I uses human subjects to determine  safety and
tolerance. Phase II uses a limited patient population to determine effectiveness
and dosage and to identify side effects.  Compounds  found effective and safe in
Phase II are further tested in Phase III with an expanded patient  population at
geographically  dispersed  clinical study sites. Each phase may last from one to
two years or more.

Most  products are not approved  because of the failure to  demonstrate  safety,
effectiveness, or both. The FDA may suspend clinical trials at any time if it is
felt that subjects or patients are being exposed to an unacceptable health risk.
Obtaining FDA approval  requires  substantial  time and effort.  There can be no
assurance that any approval will be granted to Epitope on a timely basis,  if at
all.  As part of the  approval  process,  the FDA may  require  the  Company  to
initiate post-approval marketing studies.

Medical Devices.  Medical devices are classified either in Class I, Class II, or
Class III. Class I devices are subject only to general control provisions of the
Federal Food, Drug, and Cosmetic Act, as amended (the FDC Act). These provisions
include  requirements  that a device not be adulterated or misbranded.  Class II
devices  are those for which  general  controls  are  insufficient  to provide a
reasonable   assurance  of  safety  and  efficacy  and  for  which  a  "generic"
performance standard or other special controls are appropriate.  Devices that do
not meet the criteria for Class I or II are placed in Class III.  Class I and II
devices,  those Class III  devices  initially  marketed  prior to passage of the
Medical  Device   Amendments  of  1976  (MDA)  for  which   premarket   approval
applications (PMAs) are not yet required,  and devices substantially  equivalent
to such devices, may be marketed upon FDA clearance of a Premarket  Notification
(a 510(k)).  Other Class III devices may be commercially marketed only after FDA
approval of a PMA. Generally,  the process of obtaining FDA approval of a PMA is
similar to that for obtaining approval of a biological or other drug product.

Based upon the  information  provided in a 510(k) Notice  regarding the device's
intended use and  technological  features,  the FDA will  determine  whether the
device is  "substantially  equivalent"  to a predicate  device,  i.e.,  a device
legally  marketed  which  did not  require  a PMA.  If a  device  is found to be
substantially equivalent to a predicate device, it may be freely marketed in the
United States so long as the device is otherwise in compliance with the FDC Act.
If it is not so found, it will be considered a Class III device requiring a PMA.
Substantial equivalence means


                                     - 10 -
<PAGE>


that  the FDA has  found  that  the  device  has the  same  intended  use as the
predicate device, and either has the same  technological  characteristics or has
different  characteristics,  but there is  information in the 510(k) Notice that
shows the device is as safe and  effective as the predicate and does not present
different questions of safety and effectiveness.

OraSure Collection Device. Use of the OraSure collection device for applications
involving the detection of antibodies to HIV is regulated by the FDA as use of a
Class III medical  device  requiring a PMA. In December  1994,  the FDA approved
Epitope's  PMA for use of the  OraSure  device in HIV  screening.  Post-approval
marketing studies are under way as required as part of the FDA's approval of the
OraSure  device.  In June 1996,  the FDA approved the PMA for use of the OraSure
oral  specimen-based  Western blot confirmatory test kit for HIV-1 diagnosis.  A
second generation HIV-1 antibody EIA test for OraSure samples is currently under
review by the FDA.

The Company has also applied for regulatory  clearance of the use of the OraSure
device for HIV testing  (device,  screening test, and Western Blot  confirmatory
test) in Canada.

Epitope has submitted  510(k)  Notices for use of OraSure in testing for several
drugs of abuse.  These  submissions  are currently  undergoing  FDA review.  See
"Business-- Products Under  Development--OraSure."  In the meantime, the FDA has
advised Epitope that OraSure may be used for cocaine testing for the purposes of
life insurance risk assessment.

Western Blot Test Kits.  Epitope's HIV-1 Western blot  serum-based  confirmatory
test kits are used to confirm whether  individuals are infected with HIV-1. They
are regulated by the FDA as biological  products,  unlike most other  diagnostic
tests which are regulated as medical devices. In March 1991, the FDA cleared the
EPIblot HIV-1 serum-based confirmatory test kit for commercial distribution.  As
noted above, a PMA seeking permission to market the OraSure oral  specimen-based
Western blot  confirmatory  test kit for HIV-1 diagnosis was approved by the FDA
in June 1996.

Manufacturing  Regulations.  Every company that manufactures  drugs,  biological
products,  or medical  devices  distributed  in the United  States is subject to
inspections  by  the  FDA  and  must  comply  with  the  FDA's  Quality  Systems
regulations.   These  regulations  govern,  among  other  matters,  manufacture,
testing, release, packaging, distribution,  documentation, purchasing and design
control.

Other.  Epitope is also subject to  regulation  by the  Occupational  Safety and
Health Administration and may be subject to regulation by the U.S. Environmental
Protection  Agency  (EPA) under the Toxic  Substances  Control  Act (TSCA),  the
Resource  Conservation and Recovery Act, and other legislation.  Epitope is also
subject to foreign regulations governing, for example, human clinical trials and
marketing  with  respect to  products  distributed  outside  the United  States.
Approval processes vary from country to country, and the length of time required
for approval or to obtain other clearances may in some cases be longer than that
required for U.S.  governmental  approvals.  The extent of  potentially  adverse
governmental   regulation   affecting  Epitope  that  might  arise  from  future
legislative or administrative action cannot be predicted.

TARGETED STOCK AND AGRITOPE SPIN-OFF

In November 1996,  the Epitope board of directors  (the Epitope Board)  proposed
creating  two  separate  classes of Epitope  common  stock,  one to reflect  the
business and operations of the Epitope Medical  Products  business and the other
to  reflect  the  business  and  operations  of  Agritope,  then a wholly  owned
subsidiary  engaged in the  agricultural  biotechnology  business  (the Targeted
Stock Proposal).  In May 1997, prior to a shareholder vote on the Targeted Stock
Proposal,   the  Epitope  Board   withdrew  the  Targeted  Stock  Proposal  from
consideration.  In July 1997,  the Epitope Board approved a proposal to spin off
Agritope,  subject to obtaining  financing for Agritope and the  satisfaction of
certain  other  conditions,  in a  distribution  to  Epitope  shareholders  (the
Agritope Spin-off).  In late December 1997, Epitope expects to distribute all of
its  ownership  interest in Agritope to Epitope's  shareholders  through a stock
dividend.  Epitope  will then no longer  own or control  any shares of  Agritope
stock.


                                     - 11 -
<PAGE>


DISCONTINUED OPERATIONS

Agritope.  Agritope (then named Agricultural Genetic Systems, Inc.) was acquired
by Epitope  in 1987.  Agritope  consists  of two units:  Agritope  Research  and
Development  (Agritope  R&D) and Vinifera,  Inc.  (Vinifera).  Agritope R&D uses
biotechnology  in the development of new fruit and vegetable plant varieties for
sale to the  fresh  produce  industry.  To  date,  Agritope  has  not  completed
commercialization of this technology.  A portion of the research and development
efforts  conducted by Agritope has been performed under various  research grants
and contracts. Vinifera is engaged in the grapevine propagation and distribution
business.  During 1995,  Vinifera  was in the  development  stage and  generated
minimal product sales.  Vinifera commenced  commercial stage operations in 1996.
Agritope's results of operations are presented as discontinued operations in the
consolidated  financial  statements  included in this Annual Report on Form 10-K
for all periods presented.  Agritope's net assets are presented in the September
30,  1997  balance  sheet  as  net  assets  of  discontinued   operations.   All
intercompany  loans from  Epitope to  Agritope  have been  reflected  as capital
contributions to Agritope consistent with the separation agreement dated between
Agritope  and Epitope  dated  December  1, 1997,  which also  provides  that net
expenses of Agritope  after that date will be borne by Agritope,  subject to the
completion of the Agritope Spin-off.

Andrew and  Williamson  Sales,  Co. On December 12,  1996,  a subsidiary  of the
Company  completed a merger with  Andrew and  Williamson  Sales,  Co.  (A&W),  a
producer and wholesale  distributor  of fresh and frozen  fruits and  vegetables
based in San  Diego,  California.  Under the terms of the  merger,  the  Company
issued  520,000  shares  of  Epitope  common  stock in  exchange  for all of the
outstanding common stock of A&W.

On May 27, 1997, in  accordance  with the terms of a rescission  agreement,  the
former  shareholders  of A&W returned the 520,000 shares of Epitope common stock
they received,  and Epitope returned all of the outstanding shares of A&W common
stock. Epitope also received A&W preferred stock in satisfaction of intercompany
loans  made to A&W  between  December  12,  1996 and  March 19,  1997.  This A&W
preferred  stock  carries  a  $5.7  million  liquidation  preference,   dividend
preferences,  and various  redemption  features.  In  addition,  the Company has
provided a guarantee to Wells Fargo Bank for a credit  facility  provided to A&W
which has a  borrowing  limit of $6.5  million.  This  credit line is secured by
A&W's  accounts  receivable,  inventory  and  equipment,  as well as by personal
guarantees from the owners of A&W, who have agreed to reimburse  Epitope for any
amounts the Company is required to pay under the guarantee.

SUPPLIES

The HIV-1 antigen needed to manufacture  Epitope's Western blot HIV confirmatory
test kits is available from only a limited number of sources.  Organon  Teknika,
the  exclusive  distributor  of the test kits,  is required to supply  Epitope's
requirements  for  antigen  for the  term  of its  distribution  agreement  with
Epitope,  which ends March 31, 1998. If for any reason Organon Teknika should no
longer  be able to supply  the  Company's  antigen  needs,  management  believes
Epitope would be able to obtain its own supply of antigen at a competitive cost.
A change in the antigen  would  require  FDA  approval.  Epitope has  obtained a
license from the National  Technical  Information  Service which is required for
the production of the HIV-1 antigen currently used in the Company's Western blot
test kits,  although it is unlikely that Epitope would choose to manufacture its
own antigen because of its availability from other suppliers.

Other materials used by Epitope in manufacturing,  production,  and research and
development operations are widely available from a variety of sources.

GRANTS AND CONTRACTS
Epitope has received funding in the past from the National  Institute of Allergy
and Infectious  Diseases (NIAID),  for work in developing a rapid test to detect
HIV antibodies in oral fluid  specimens,  and from the National Cancer Institute
(NCI) to fund research for the treatment of cancer by exploiting a deficiency of
certain  compounds in cancer cells.  As a part of the SB Agreement,  various R&D
projects at Epitope were funded by SB, in exchange for certain  marketing rights
to products which would have resulted from the development. With the termination
of the SB Agreement, Epitope regained the rights to the results of the work that
had been  accomplished  under this funding.  The Company  intends to continue to
participate in grant programs and projects with strategic partners as it deems


                                     - 12 -
<PAGE>


appropriate.  The Company regularly makes applications for new grants, but there
is no assurance that grant support will be continued.

PATENTS AND PROPRIETARY INFORMATION

Epitope has obtained patents in the United States and certain foreign  countries
for the OraSure and OraQuick devices and related technology. Epitope has applied
for  additional  patents,  both in the  United  States  and in  certain  foreign
countries,  on the OraSure  collection device and a number of other technologies
and products.  The Company anticipates filing patent applications for protection
on future  products and  technology.  United  States  patents  generally  have a
maximum term of 20 years from the date an  application is filed or 17 years from
issuance, whichever is longer.

Much of the  technology  developed  by the  Company is  subject to trade  secret
protection.  To  reduce  the risk of loss of  trade  secret  protection  through
disclosure,  the Company  requires its employees and  consultants  to enter into
confidentiality  agreements.  The Company  believes that patent and trade secret
protection  is important to its business.  However,  the issuance of a patent or
existence of trade secret  protection  does not in itself  ensure the  Company's
success.  Competitors may be able to produce products  competing with a patented
Company product without infringing on the Company's patent rights. Issuance of a
patent in one  country  generally  does not prevent  manufacture  or sale of the
patented product in other countries.  The issuance of a patent to the Company or
to a licenser is not conclusive as to validity or as to the enforceable scope of
the patent.  The validity or  enforceability  of a patent can be  challenged  by
litigation after its issuance, and, if the outcome of such litigation is adverse
to the owner of the patent, the owner's rights could be diminished or withdrawn.
Trade secret protection does not prevent independent  discovery and exploitation
of the secret product or technique.

PERSONNEL

At  September  30,  1997,  the Company and its  subsidiaries  had 130  full-time
employees,  including  85  persons  employed  by  Epitope,  and 45  employed  by
Agritope.  Epitope  employees  included  15  persons  in  research  and  product
development,  25  in  administration  and  marketing,  34 in  manufacturing  and
production,  and  11 in  regulatory  affairs  and  quality  assurance.  Agritope
employees  included 22 in research and  development and 23 at the Vinifera grape
plant  nursery  operation  which also employs  seasonal  part-time  employees as
needed.  The Company considers its relations with its employees to be excellent.
None of its employees are represented by labor unions.

The Company and its subsidiaries employ 12 persons holding Ph.D. or M.D. degrees
with   specialties   in  the  following   disciplines:   analytical   chemistry,
bacteriology  and  public  health,  biochemistry,   biophysics,  hematology  and
internal  medicine,  immunology,  molecular biology,  organic  chemistry,  plant
biology and plant  pathology.  From time to time,  the Company  also engages the
services of scientists as  consultants  to augment the skills of its  scientific
staff.

SCIENTIFIC ADVISORY BOARD

The Company  also  utilizes the services of a  Scientific  Advisory  Board.  The
Scientific  Advisory Board meets  periodically to review the Company's  research
and  development  efforts and to apprise the Company of scientific  developments
pertinent to the Company's  business.  The Scientific  Advisory Board  comprises
chair Daniel Malamud,  Ph.D.,  Professor and Chair,  Department of Biochemistry,
University of Pennsylvania School of Dental Medicine;  J. Richard George, Ph.D.,
Vice President of Scientific Affairs of Epitope;  Lesley M. Hallick, Ph.D., Vice
President for Academic Affairs, Oregon Health Sciences University;  and James I.
Mullins,   Ph.D.,   Professor  of  Microbiology  and  Medicine,   University  of
Washington;   and  John  V.  Parry,   Ph.D,   Deputy  Director,   Hepatitis  and
Retrovirology  Laboratory,  Central Public Health  Laboratory,  Virus  Reference
Division, London.


                                     - 13 -
<PAGE>


                    NOTE REGARDING FORWARD-LOOKING STATEMENTS

The previous  discussion of the Company's business should be read in conjunction
with the consolidated  financial statements and notes thereto included elsewhere
in this  Annual  Report on Form  10-K.  Statements  regarding  future  events or
performance  set forth in this report  constitute  "forward-looking  statements"
within the meaning of the Private Securities  Litigation Reform Act of 1995. The
forward-looking  statements  involve known and unknown risks,  uncertainties and
other factors that may cause the actual results,  performance or achievements of
the  Company or  industry  results to be  materially  different  from any future
results, performance or achievements expressed or implied by the forward-looking
statements. These factors with respect to the Company include loss or impairment
of sources of capital;  ability of the Company to develop  product  distribution
channels;  development of competing products;  market acceptance of oral testing
products;  changes  in  federal  or state  law or  regulations;  and loss of key
personnel.  Given these uncertainties,  readers are cautioned not to place undue
reliance on the forward-looking statements.











ITEM 2.  PROPERTIES.

The Company leases  approximately  35,600 square feet of office,  manufacturing,
and  laboratory  space in  Beaverton,  Oregon,  under two leases that  terminate
January 31, 2000. Each lease calls for fixed monthly payments over its term. The
Company also entered into a three-year  lease,  effective  October 1, 1996,  for
2,265 square feet of warehouse space used to store inventory and equipment.


ITEM 3.  LEGAL PROCEEDINGS.

None.


ITEM 4.  SUBMISSION OF MATTERS TO A VOTE OF SECURITY HOLDERS.

No  matters  were  submitted  to a vote of  security  holders  during the fourth
quarter of the fiscal year covered by this report.


                                     - 14 -
<PAGE>


                                     PART II

ITEM 5.  MARKET  FOR THE  REGISTRANT'S  COMMON  STOCK  AND  RELATED  STOCKHOLDER
         MATTERS.

The Company's  Common Stock is listed for trading on the National Market tier of
The Nasdaq Stock Market  ("NASDAQ") under the symbol EPTO. Prior to Jan 2, 1997,
the Company's Common Stock was listed for trading on the American Stock Exchange
("AMEX") under the symbol EPT. High and low sales prices  reported by NASDAQ and
AMEX during the periods indicated are shown below.


                             SALES PRICES PER SHARE

YEAR ENDED SEPTEMBER 30                  1997                        1996

                                   HIGH          LOW         HIGH          LOW

First Quarter                    $ 16.375     $ 10.875     $ 18.00       $ 9.50

Second Quarter                     17.375        9.75        19.50        13.875

Third Quarter                      11.125        6.25        22.875       15.50

Fourth Quarter                      8.625        4.625       16.125       11.75


On December 1, 1997, there were 1,004 holders of record of the Common Stock, and
the closing price of the Common Stock was $5.75.  The Company has never paid any
cash  dividends,  and the Board of  Directors  does not  anticipate  paying cash
dividends in the  foreseeable  future.  The Company intends to retain any future
earnings to provide funds for the operation and expansion of its business.

On September  30, 1997,  the Company  issued  209,368  shares of Common Stock to
SmithKline  Beecham plc in a private  placement  in exchange for  $1,500,000  in
cash. The shares were issued in reliance on Rule 506 of Regulation D promulgated
under the Securities Act of 1933, as amended. SB is an accredited  investor,  as
defined  in  Regulation  D. The  Company  filed a Form D  regarding  sale of the
shares.


                                     - 15 -
<PAGE>


ITEM 6.  SELECTED FINANCIAL DATA.

                           COMPARATIVE FINANCIAL DATA
                      (In thousands, except per share data)

The  following  table sets forth  selected  historical  consolidated  income and
balance sheet data of Epitope, Inc. and its subsidiaries. The balance sheet data
at  September  30, 1997 and 1996 and the  operating  results  data for the years
ended  September  30,  1997,  1996,  and 1995 have  been  derived  from  audited
consolidated  financial  statements  and notes  thereto  included in this Annual
Report on Form 10-K. The balance sheet data at September 30, 1995, 1994 and 1993
and operating  results data for the years ended September 30, 1994 and 1993 have
been derived from audited  consolidated  financial  statements and notes thereto
not  included  in this  Annual  Report  on Form  10-K  and,  in the  opinion  of
management,  include  all  adjustments  necessary  for fair  presentation.  This
information  should  be read in  conjunction  with  the  consolidated  financial
statements and notes thereto  included in Item 8 herein and Item 7 "Management's
Discussion and Analysis of Financial Condition and Results of Operations."

                           COMPARATIVE FINANCIAL DATA
                      (In thousands, except per share data)

<TABLE>
YEAR ENDED SEPTEMBER 30                                   1997        1996         1995         1994         1993

OPERATING RESULTS
<S>                                                  <C>          <C>           <C>          <C>          <C>
Revenues.........................................    $   9,360    $   5,594     $  2,856     $  2,605     $   2,759
Operating costs and expenses.....................       14,324       10,881       14,463        8,890         9,376
Other income (expense), net......................          882        6,388(1)     1,157          456        (1,154)
Profit (loss) from continuing operations.........       (4,081)       1,101      (10,451)      (5,829)       (7,771)
Discontinued operations..........................      (18,359)      (2,501)      (8,045)      (9,804)       (6,958)
Net loss.........................................      (22,440)      (1,400)     (18,496)     (15,633)      (14,729)
Profit (loss) per share from continuing
  operations.....................................         (.30)         .08(2)      (.88)        (.58)        (.88)
Net loss per share...............................        (1.67)        (.11)       (1.56)       (1.56)       (1.67)
Shares used in per share
 calculations....................................       13,404       12,661(2)    11,886       10,050         8,828

BALANCE SHEET DATA
Working capital..................................    $   9,538    $  24,793     $ 20,686     $ 16,766     $   8,703
Total assets.....................................       17,012       29,784       26,142       19,993         9,071
Accumulated deficit..............................      (95,426)     (72,985)     (71,585)     (53,090)      (37,457)
Shareholders' equity.............................       15,014       27,967       22,347       18,470         7,970
</TABLE>

(1) Includes one-time licensing fee of $5.0 million.

(2)  13,440,000  shares used in calculation of profit per share from  continuing
     operations due to common stock equivalents.


                                     - 16 -
<PAGE>


ITEM 7. MANAGEMENT'S  DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS
OF OPERATIONS.

The following discussion of operations and financial condition should be read in
conjunction  with  the  consolidated  financial  statements  and  notes  thereto
included  elsewhere in this Annual Report on Form 10-K.  Certain  statements set
forth below constitute  "forward-looking  statements"  within the meaning of the
Private Securities Litigation Reform Act of 1995. The forward-looking statements
involve known and unknown risks,  uncertainties and other factors that may cause
the actual  results,  performance  or  achievements  of the  Company or industry
results to be  materially  different  from any future  results,  performance  or
achievements  expressed  or implied  by the  forward-looking  statements.  These
factors with respect to the Company  include  loss or  impairment  of sources of
capital;  ability  of the  Company  to develop  product  distribution  channels;
development of competing  products;  market acceptance of oral testing products;
changes in federal or state law or regulations; and loss of key personnel. Given
these  uncertainties,  readers are cautioned not to place undue  reliance on the
forward-looking statements.

                      TARGETED STOCK AND AGRITOPE SPIN-OFF

In November 1996, the Epitope Board  proposed  creating two separate  classes of
Epitope common stock,  one to reflect the business and operations of the Epitope
medical  products  business and the other to reflect the business and operations
of Agritope (the "Targeted Stock Proposal"). In May 1997, prior to a shareholder
vote on the Targeted  Stock  Proposal,  the Epitope Board  withdrew the Targeted
Stock Proposal from consideration.  In July 1997, the Epitope Board approved the
Agritope  Spin-off,   subject  to  obtaining  financing  for  Agritope  and  the
satisfaction  of certain  other  conditions.  In October 1997,  commitments  for
financing  for  Agritope  considered  to be adequate  by the Epitope  Board were
obtained.  In late  December  1997,  Epitope  expects to  distribute  all of its
ownership  interest  in  Agritope  to  Epitope's  shareholders  through  a stock
dividend.  Epitope  will then no longer  own or control  any shares of  Agritope
stock.

                             DISCONTINUED OPERATIONS

Agritope.  Agritope is a wholly owned  subsidiary  of Epitope  acquired in 1987.
Agritope  consists of two units:  Agritope R&D and  Vinifera.  Agritope R&D uses
biotechnology  in the development of new fruit and vegetable plant varieties for
sale to the  fresh  produce  industry.  To  date,  Agritope  has  not  completed
commercialization of this technology.  A portion of the research and development
efforts  conducted by Agritope has been performed under various  research grants
and contracts. Vinifera is engaged in the grapevine propagation and distribution
business.  During 1995,  Vinifera  was in the  development  stage and  generated
minimal product sales.  Vinifera commenced  commercial stage operations in 1996.
Agritope's  results of operations  and net assets are presented as  discontinued
operations  in the  consolidated  financial  statements  included in this Annual
Report on Form 10-K for all  periods  presented.  All  intercompany  loans  from
Epitope to Agritope  have been  reflected as capital  contributions  to Agritope
consistent  with the separation  agreement dated December 1, 1997. The 1997 loss
from discontinued operations of Agritope includes an accrual of $1.2 million for
Agritope's  operating  losses from October 1, 1997 through  December 1, 1997 and
for costs of the Agritope Spin-off.  The separation  agreement provides that net
expenses of Agritope after December 1, 1997 will be borne by Agritope.

Andrew and  Williamson  Sales,  Co. On December 12,  1996,  a subsidiary  of the
Company  completed a merger with  Andrew and  Williamson  Sales,  Co.  (A&W),  a
producer and wholesale  distributor  of fresh and frozen  fruits and  vegetables
based in San  Diego,  California.  Under the terms of the  merger,  the  Company
issued  520,000  shares  of  Epitope  common  stock in  exchange  for all of the
outstanding common stock of A&W.

On May 27, 1997, in  accordance  with the terms of a rescission  agreement,  the
former  shareholders  of A&W returned the 520,000 shares of Epitope common stock
they received,  and Epitope returned all of the outstanding shares of A&W common
stock. Epitope also received A&W preferred stock in satisfaction of intercompany
loans  made to A&W  between  December  12,  1996 and  March 19,  1997.  This A&W
preferred  stock  carries  a  $5.7  million  liquidation  preference,   dividend
preferences, and various redemption features.


                                     - 17 -
<PAGE>


A&W's  results of  operations  for the period from December 13, 1996 through May
27, 1997 are presented in the consolidated financial statements included in this
Annual Report on Form 10-K as  discontinued  operations.  The estimated  loss on
disposal of $8.4 million results from several factors,  including a $1.8 million
reduction in market price of the  Company's  stock from the purchase date to the
rescission  date,  a $5.7  million  discount of the A&W  preferred  stock to its
estimated  net present  value as compared with the face amount of the loans made
to A&W, the write-off of $633,000 in A&W acquisition  costs,  and the accrual of
$262,000 in estimated costs associated with the rescission.

                              RESULTS OF OPERATIONS

The table below shows the amount (in  thousands)  and  percentage  of  Epitope's
total revenue  contributed  by each of its principal  products and by grants and
contracts.

<TABLE>

FISCAL YEAR                                                   1997                  1996                  1995
Product Sales
<S>                                                     <C>         <C>       <C>         <C>      <C>         <C>
Oral specimen collection devices.....................   $6,279       67%      $3,311       59%     $   981       34%
Western blot HIV confirmatory tests..................    1,791       19        1,540       28        1,811       64
Other product sales..................................       14        -           14        -           15        -
                                                        ------      ---       ------      ---       ------      ---
                                                         8,084       86        4,865       87        2,807       98

Grants and contracts.................................    1,276       14          729       13           49        2
                                                       -------      ---       ------      ---       ------      ---
                                                        $9,360      100%      $5,594      100%      $2,856      100%
</TABLE>

Revenues.  Product  sales  increased  by $3.2 million or 66 percent from 1996 to
1997 and by $2.1 million or 73 percent  from 1995 to 1996  primarily as a result
of expanded sales volume of Epitope's lead product, the  EpiScreen/OraSure  oral
specimen  collection  device.  Approximately  39  percent  of  1996  sales  were
attributable  to shipments in the fourth quarter.  The  significant  increase in
sales volume of the OraSure  device is primarily  due to increased  purchases of
the device by the Company's  distributors for the life insurance  testing market
following  approval of the device by the FDA in June 1996 for use in conjunction
with an oral-based  confirmatory test. Sales of the device to the life insurance
testing market in the fourth  quarter of fiscal 1997 were adversely  affected by
reductions in orders as several of the Company's  distributors  reduced existing
inventory levels. Sales in the life insurance market are expected to continue to
be at reduced levels in the first quarter of fiscal 1998,  with growth  expected
in both the insurance and public health markets in the second quarter.

Sales in 1997 also reflect  increased  sales in the public  health market due to
the marketing  efforts of SB, the Company's  former marketing  partner.  In July
1997, as a result of SB's decision to  discontinue  pursuit of a plan to develop
and market  over-the-counter  products for disease detection,  SB terminated its
development,  license and supply  agreement with Epitope.  Because the agreement
was terminated,  Epitope regained  OraSure  marketing rights from SB. During the
transition  period in August and  September of 1997,  SB continued to market the
OraSure testing system to the medical community.  Beginning in October 1997, the
product is being marketed through Epitope's direct sales force.

As  of  September  30,  1997,  the  Company  had  firm  orders  and  contractual
commitments  for the OraSure  device and the  Western  Blot  confirmatory  tests
respectively totaling approximately $900,000 and $450,000 scheduled for shipment
within 90 days,  as compared to firm orders for delivery  within 90 days of $1.8
million and $450,000 respectively as of September 30, 1996.

Sales of the Company's  Western blot HIV confirmatory test increased by $251,000
or 16 percent  from 1996 to 1997 and  decreased  by $271,000 or 15 percent  from
1995 to 1996.  Sales in 1996 were  negatively  affected by a reduction in orders
from the Company's  exclusive  distributor  for this product as the  distributor
lowered inventory levels. In addition, 1997 sales of the oral-based Western blot
HIV confirmatory test have increased as a result of increased use of the related
oral specimen  collection  device and screening  test. As of September 30, 1997,
the Company had firm orders for the Western blot HIV confirmatory  test totaling
$450,000 scheduled for shipment before December 31, 1997.


                                     - 18 -
<PAGE>


Grant and  contract  revenues  increased  by $547,000 or 75 percent from 1996 to
1997 and by  $681,000  or 14 fold from 1995 to 1996 due to funding  of  research
projects by the Company's  former  development  partner,  SB. In July 1997,  the
Company's development,  license and supply agreement with SB was terminated, and
the R&D  funding  by SB was  curtailed.  Discussions  are  underway  with  other
potential partners who might replace some or all of this R&D funding.

Gross Margin on product  sales was 57 percent in 1997,  45 percent in 1996,  and
negative in 1995. The  improvement in gross margins is attributable to increased
sales and production  volumes for the OraSure device which resulted in lower per
unit costs and to the shift in product  mix towards  the  OraSure  device  which
carries a higher gross margin than does the Western blot HIV confirmatory  test.
The gross  margin in the fourth  quarter of 1997 was  adversely  affected by the
disposal  of  inventory  on hand which was  manufactured  with SB  labeling  and
packaging  when  the  development,  license  and  supply  agreement  with SB was
terminated. Excluding the inventory adjustment, the gross margin would have been
59 percent in 1997.

Research and Development  Expenses.  Research and development expenses increased
by $991,000 or 31 percent from 1996 to 1997 and  decreased by $1.5 million or 31
percent from 1995 to 1996.  The decrease in 1996 was primarily  attributable  to
cost  reductions  associated  with the Company's  September  1995  restructuring
program as well as lower  levels of clinical  trials  activity.  The increase in
1997 was  primarily  the  result  of  increased  levels  of  research  activity,
including several clinical studies, conducted under arrangements with SB and for
other  projects  performed by the Company.  Plans are in place to reduce the R&D
expense for 1998,  unless  additional  funding is forthcoming from potential new
partners.

Selling,   General   and   Administrative   Expenses.   Selling,   general   and
administrative  expenses  increased  by $1.6  million or 32 percent from 1996 to
1997 and decreased by $1.6 million or 25 percent from 1995 to 1996. The increase
in 1997 was primarily attributable to higher corporate and marketing expenses as
the  Company  expanded  its  direct  sales  efforts.  The  decrease  in 1996 was
primarily  due to the  results of the  Company's  September  1995  restructuring
program.   Selling,  general  and  administrative  expenses  for  1995  included
approximately  $607,000 for severance  payments and other costs  associated with
implementing the restructuring program. In addition,  marketing expenses in 1996
were $754,000 lower than in 1995 as a result of the restructuring  program. 1998
sales expenses are expected to increase as a result of direct marketing  efforts
by the Company in the public health market.

Selling,  general and administrative expenses have been reduced by $1.4 million,
$1.1 million and $1.9 million in 1997, 1996 and 1995, respectively,  for amounts
allocated  to  Agritope  (see  "Discontinued  Operations").   Certain  corporate
overhead  services  such as  accounting,  annual  meeting  costs,  annual report
preparation,   audit,  executive  management,   facilities,   finance,   general
management,  human resources,  information  systems,  investor relations,  legal
services,  payroll and SEC  filings  were  provided by Epitope on a  centralized
basis for the benefit of the medical products business and for Agritope ("Shared
Services").  Such  expenses  have been  allocated  between the medical  products
business  and  Agritope  using  activity  indicators  which,  in the  opinion of
management,  represent a reasonable  measure of each  business's  utilization of
such Shared  Services.  Epitope and Agritope  have  entered into a  transitional
services  agreement  whereby,  following  the  Agritope  Spin-off,  Epitope will
continue to provide  certain of these  services to Agritope  and  Agritope  will
reimburse  Epitope for the cost of such services  during a transitional  period.
The  allocation  of Shared  Services to  Agritope  is expected to  significantly
decrease in 1998 as Agritope eventually moves to separate  facilities.  However,
the Company has  implemented a cost  reduction plan for 1998 that is expected to
result in savings in selling,  general,  and administrative  expenses to off-set
the reduction in allocations to Agritope.

Other Income (Expense), Net. Other income for 1996 included $5.0 million related
to license fees  received from SB as a result of FDA approval of an extension of
dating for the  OraSure/EpiScreen  device.  Interest  income  decreased in 1997,
primarily due to lower levels of invested funds.


                                     - 19 -
<PAGE>


LIQUIDITY AND CAPITAL RESOURCES

(IN THOUSANDS)                                     9/30/97               9/30/96
Cash and cash equivalents................         $  1,934             $   5,223
Marketable securities....................            7,142                18,818
Working capital..........................            9,532                24,793

Net cash flows from operating  activities  improved  significantly  from 1995 to
1996 as a result of improved operating results and the receipt of a $5.0 million
license fee from SB in 1996.  Cash flows from operations in 1997 did not include
such a payment.  Proceeds from the issuance of equity securities of the Company,
augmented by funding from  strategic  partners and other research  grants,  have
represented the primary sources of funds for meeting the Company's  requirements
for operations,  working capital and business  expansion.  Epitope received $1.5
million  for the  issuance  of common  stock in a 1997  private  placement.  The
Company also received proceeds of $168,000,  $5.9 million and $21.0 million from
the exercise of warrants and options to purchase  common stock in 1997, 1996 and
1995,  respectively.  Research  grant funding from  strategic  partners was $1.3
million,  $729,000 and $49,000 in 1997, 1996 and 1995, respectively.  Funding of
the Company's discontinued operations, Agritope and A&W, required $13.9 million,
$3.2 million and $7.8 million in 1997, 1996 and 1995, respectively.

The Company  anticipates  that it will continue to need funds to support ongoing
research and development projects as well as to provide additional manufacturing
capacity and related increases in working capital to support growth. The Company
intends to utilize  cash  reserves,  cash  generated  from sales of products and
research funding from strategic partners to provide some of the necessary funds.
The Company is also exploring  opportunities  to generate  additional funds from
the sale of equity  securities,  and may receive  funds  through the exercise of
outstanding stock options and warrants.


ITEM 7A.      QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK
Not applicable.


                                     - 20 -
<PAGE>


ITEM 8.       FINANCIAL STATEMENTS AND SUPPLEMENTARY DATA.

Information  with respect to this Item is (i) set forth below and (ii) contained
in the Company's  Consolidated  Financial Statements included in Item 14 of this
Annual Report on Form 10-K.

                   QUARTERLY RESULTS OF OPERATIONS (UNAUDITED)
                 (In thousands, except income (loss) per share)

The following table presents summarized quarterly results of operations for each
of the fiscal  quarters in the Company's  fiscal years ended  September 30, 1997
and 1996.  These  quarterly  results  are  unaudited,  but,  in the  opinion  of
management,  have  been  prepared  on the same  basis as the  Company's  audited
financial  information  and include all adjustments  (consisting  only of normal
recurring  adjustments) necessary for a fair presentation of the information set
forth  therein.  The data should be read in  conjunction  with the  Consolidated
Financial  Statements  and  related  notes  thereto  included in Item 14 of this
Annual Report on Form 10-K.

<TABLE>
                                                         FIRST       SECOND        THIRD       FOURTH
                                                       QUARTER       QUARTER      QUARTER      QUARTER       TOTAL
YEAR ENDED SEPTEMBER 30, 1997
<S>                                                  <C>          <C>           <C>          <C>          <C>
Revenues.........................................    $   2,641    $   2,336     $  2,884     $  1,500     $   9,360
Operating costs and expenses.....................        3,251        3,574        4,005        3,494        14,324
Other income, net................................          319          274          173          116           882
Loss from continuing operations..................         (291)        (964)        (948)      (1,878)       (4,081)
Discontinued operations..........................       (4,093)      (9,202)      (1,366)      (3,698)      (18,359)
Net loss.........................................       (4,384)     (10,166)      (2,314)      (5,576)      (22,440)
Loss per share from continuing operations........         (.02)        (.07)        (.07)        (.14)         (.30)
Net loss per share...............................         (.34)        (.74)        (.17)        (.42)        (1.67)

YEAR ENDED SEPTEMBER 30, 1996
Revenues.........................................    $   1,225    $   1,207     $  1,107     $  2,055     $   5,594
Operating costs and expenses.....................        2,510        2,819        2,507        3,045        10,881
Other income, net................................          293          283        5,485(1)       327         6,388
Income (loss) from continuing operations.........         (992)      (1,329)       4,085         (663)        1,101
Discontinued operations..........................         (660)        (488)        (585)        (768)       (2,501)
Net income (loss)................................       (1,652)      (1,817)       3,500       (1,431)       (1,400)
Income (loss) per share from continuing
   operations....................................         (.08)        (.11)         .30         (.05)          .08
Net income (loss) per share......................         (.13)        (.14)         .25         (.11)         (.11)
</TABLE>

(1)   Includes license fee of $5.0 million from SmithKline Beecham, plc.






ITEM  9.  CHANGES  IN AND  DISAGREEMENTS  WITH  ACCOUNTANTS  ON  ACCOUNTING  AND
FINANCIAL DISCLOSURE.

None.


                                     - 21 -
<PAGE>


                                    PART III

The Company has omitted  from Part III the  information  that will appear in the
Company's definitive proxy statement for its 1998 annual meeting of shareholders
(the "Proxy  Statement"),  which will be filed  within 120 days after the end of
the Company's fiscal year pursuant to Regulation 14A.

ITEM 10. DIRECTORS AND EXECUTIVE OFFICERS OF THE REGISTRANT.

The  information  required  by this Item is  incorporated  by  reference  to the
information under the captions "Election of Directors" and "Executive  Officers"
in the Proxy Statement.

ITEM 11. EXECUTIVE COMPENSATION.

The  information  required  by this Item is  incorporated  by  reference  to the
information under the caption "Executive Compensation" in the Proxy Statement.

ITEM 12. SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT.

The  information  required  by this Item is  incorporated  by  reference  to the
information under the caption "Principal Shareholders" in the Proxy Statement.

ITEM 13. CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS.

The  information  required  by this Item is  incorporated  by  reference  to the
information under the caption "Certain Transactions" in the Proxy Statement.






                                     PART IV

ITEM 14. EXHIBITS, FINANCIAL STATEMENT SCHEDULES, AND REPORTS ON FORM 8-K.

(a)(1) and (a)(2)  Consolidated Financial Statements and Schedules.


                                     - 22 -
<PAGE>


INDEX TO FINANCIAL STATEMENTS                                               Page

Report of Independent Accountants............................................ 24

Consolidated Balance Sheets at September 30, 1997 and 1996................... 25

Consolidated Statements of Operations for years ended
   September 30, 1997, 1996, and 1995........................................ 26

Consolidated Statements of Changes in Shareholders' Equity for years ended
   September 30, 1997, 1996, and 1995........................................ 27

Consolidated Statements of Cash Flows for years ended
   September 30, 1997, 1996, and 1995........................................ 28

Notes to Consolidated Financial Statements................................... 29


                                     - 23 -
<PAGE>


REPORT OF INDEPENDENT ACCOUNTANTS

To the Board of Directors and Shareholders of Epitope, Inc.

In our opinion,  the accompanying  balance sheets and the related  statements of
operations,  of  changes in  shareholders'  equity,  and of cash  flows  present
fairly, in all material respects,  the financial  position of Epitope,  Inc. and
its  subsidiaries  at  September  30,  1997 and 1996,  and the  results of their
operations  and their cash flows for each of the three years in the period ended
September 30, 1997, in conformity with generally accepted accounting principles.
These financial  statements are the responsibility of the Company's  management;
our responsibility is to express an opinion on these financial  statements based
on our audits.  We conducted our audits of these  statements in accordance  with
generally accepted auditing standards which require that we plan and perform the
audit to obtain reasonable  assurance about whether the financial statements are
free of material  misstatement.  An audit includes  examining,  on a test basis,
evidence  supporting the amounts and  disclosures  in the financial  statements,
assessing the  accounting  principles  used and  significant  estimates  made by
management,  and evaluating the overall  financial  statement  presentation.  We
believe  that our audits  provide a reasonable  basis for the opinion  expressed
above.

PRICE WATERHOUSE LLP

Portland, Oregon

October 31, 1997, except for Note 3, as to which the date is December 1, 1997


                                     - 24 -
<PAGE>


EPITOPE, INC.
CONSOLIDATED BALANCE SHEETS
<TABLE>
SEPTEMBER 30                                                                         1997                  1996

ASSETS
Current assets
<S>                                                                             <C>                   <C>
Cash and cash equivalents..............................................         $   1,934,480         $   5,222,749
Marketable securities..................................................             7,141,640            18,818,120
Trade accounts receivable, net (Note 2)................................               928,047             1,147,599
Other accounts receivable..............................................               128,949               174,083
Inventories (Note 2)...................................................             1,324,647             1,157,930
Prepaid expenses.......................................................                78,240                89,518
                                                                                 ------------          ------------
Total current assets...................................................            11,536,003            26,609,999

Property and equipment, net (Note 4)...................................             1,200,988             1,542,757
Patents and proprietary technology, net (Note 2).......................               657,487               601,233
Other assets and deposits..............................................                55,099                22,759
Net assets of discontinued operations (Note 3).........................             3,562,726             1,007,607
                                                                                 ------------          ------------
                                                                                $  17,012,303         $  29,784,355

LIABILITIES AND SHAREHOLDERS' EQUITY
Current liabilities
Accounts payable.......................................................         $     110,285         $     449,169
Salaries, benefits and other accrued liabilities ......................             1,887,825             1,368,166
                                                                                 ------------          ------------
Total current liabilities..............................................             1,998,110             1,817,335

Commitments and contingencies (Notes 3 and 9)..........................                     -                     -

Shareholders' equity (Note 5)
Preferred stock, no par value - 1,000,000 shares authorized; no
  shares outstanding...................................................                     -                     -
Common stock, no par value - 30,000,000 shares authorized;  13,454,330
  and 12,937,383 shares issued and outstanding, respectively...........           110,439,726           100,952,282
Accumulated deficit....................................................           (95,425,533)          (72,985,262)
                                                                                 ------------          ------------
                                                                                   15,014,193            27,967,020

                                                                                $  17,012,303         $  29,784,355
</TABLE>

The accompanying notes are an integral part of these statements.


                                     - 25 -
<PAGE>


EPITOPE, INC.
CONSOLIDATED STATEMENTS OF OPERATIONS
<TABLE>
FOR THE YEAR ENDED SEPTEMBER 30                                         1997             1996              1995

Revenues
<S>                                                                <C>               <C>              <C>
Product sales.............................................         $   8,083,606     $  4,864,378     $   2,806,850
Grants and contracts......................................             1,276,454          729,271            48,672
                                                                    ------------      -----------      ------------
                                                                       9,360,060        5,593,649         2,855,522

Costs and expenses
Product costs.............................................             3,512,054        2,681,429         3,163,012
Research and development costs............................             4,156,996        3,165,838         4,617,246
Selling, general and administrative expenses..............             6,654,553        5,033,491         6,682,860
                                                                    ------------      -----------      ------------
                                                                      14,323,603       10,880,758        14,463,118

Loss from operations......................................            (4,963,543)      (5,287,109)      (11,607,596)

Other income (expense), net
Interest income...........................................               885,583        1,386,968         1,157,305
Interest expense..........................................                (8,165)               -                 -
License fee...............................................                     -        5,000,000                 -
Other, net................................................                 4,861            1,493              (319)
                                                                    ------------      -----------      -------------
                                                                         882,279        6,388,461         1,156,986

Net income (loss) from continuing operations..............            (4,081,264)       1,101,352       (10,450,610)

Discontinued operations (Note 3)
Loss from discontinued operations; Agritope...............            (9,890,599)      (2,501,268)       (8,045,218)
Income from discontinued operations; A&W..................               170,646                -                 -
Estimated loss on disposal of A&W.........................            (8,639,054)               -                 -
                                                                    ------------      -----------      ------------
                                                                     (18,359,007)      (2,501,268)       (8,045,218)

Net loss..................................................         $ (22,440,271)    $ (1,399,916)    $ (18,495,828)

Income (loss) per share from continuing operations........         $        (.30)    $        .08     $        (.88)

Net loss per share........................................         $       (1.67)    $       (.11)    $       (1.56)

Weighted average number of shares
 outstanding..............................................            13,404,402       12,661,420*       11,886,234
</TABLE>

* Income  per share  from  continuing  operations  calculated  using  13,440,396
weighted average shares outstanding due to common stock equivalents.

The accompanying notes are an integral part of these statements.


                                     - 26 -
<PAGE>


EPITOPE, INC.
CONSOLIDATED STATEMENTS OF CHANGES IN SHAREHOLDERS' EQUITY

<TABLE>
                                                          COMMON STOCK               ACCUMULATED

                                                    SHARES            DOLLARS           DEFICIT            TOTAL

<S>                                                 <C>             <C>             <C>                <C>
BALANCES AT SEPTEMBER 30, 1994..............        10,926,551      $ 71,559,900    $ (53,089,518)     $ 18,470,382
Common stock issued upon
  exercise of options.......................           183,525         2,145,673                -         2,145,673
Common stock issued as
  compensation..............................            16,013           266,800                -           266,800
Compensation expense for
  stock option grants.......................                 -         1,374,710                -         1,374,710
Common stock issued upon
  exercise of warrants......................         1,336,000        18,892,750                -        18,892,750
Common stock issued upon exchange of
   convertible notes........................            23,041           449,991                -           449,991
Equity issuance costs.......................                 -          (757,877)               -          (757,877)
Net loss for the year.......................                  -                -      (18,495,828)      (18,495,828)
                                                    -----------     ------------     ------------       -----------
BALANCES AT SEPTEMBER 30, 1995..............        12,485,130        93,931,947      (71,585,346)       22,346,601

Common stock issued upon
  exercise of options.......................           386,550         4,886,118                -         4,886,118
Common stock issued as compensation.........            19,353           263,586                -           263,586
Compensation expense for stock
  option grants.............................                 -         1,044,183                -         1,044,183
Common stock issued upon
  exercise of warrants......................            46,350           826,600                -           826,600
Equity issuance costs.......................                 -              (152)               -              (152)
Net loss for the year.......................                 -                 -       (1,399,916)       (1,399,916)
                                                    ----------      ------------     ------------       -----------
BALANCES AT SEPTEMBER 30, 1996..............        12,937,383       100,952,282      (72,985,262)       27,967,020

Common stock issued upon
  exercise of options.......................            16,124           168,211                -           168,211
Common stock issued as
  compensation..............................            41,088           323,938                -           323,938
Compensation expense for
  stock option grants.......................                 -           489,668                -           489,668
Common stock issued upon exchange
  of convertible notes (Note 3).............           250,367         4,529,009                -         4,529,009
Equity issuance costs.......................                 -           (86,134)               -           (86,134)
Capital contributed in rescission (Note 3)..                 -         1,820,000                -         1,820,000
Common stock issued for cash................           209,368         1,500,000                -         1,500,000
Minority interest investment in Vinifera....                 -           742,752                -           742,752
Net loss for the year.......................                 -                 -      (22,440,271)      (22,440,271)
                                                    ----------      ------------     ------------       -----------
BALANCES AT SEPTEMBER 30, 1997..............        13,454,330    $  110,439,726    $ (95,425,533)     $ 15,014,193
</TABLE>



The accompanying notes are an integral part of these statements.


                                     - 27 -
<PAGE>


EPITOPE, INC.
COMBINED STATEMENTS OF CASH FLOWS
FOR THE YEAR ENDED SEPTEMBER 30

<TABLE>
                                                                        1997             1996              1995
Cash flows from operating activities
<S>                                                                <C>               <C>              <C>
Net loss..................................................         $ (22,440,271)    $ (1,399,916)    $ (18,495,828)
Adjustments to reconcile Net loss to Net cash
  used in operating activities:
Loss from discontinued operations.........................            18,359,007                -                 -
Depreciation and amortization.............................               729,970        1,086,930         1,458,675
Loss (gain) on disposition of property....................                17,888           (1,098)              819
Decrease (increase) in receivables........................               264,686          125,025        (1,022,050)
Increase in inventories...................................              (166,717)        (233,929)         (286,903)
Decrease (increase) in prepaid expenses...................                11,278           69,133           (17,608)
(Increase) decrease in other assets and deposits..........               (32,340)          20,649           (33,521)
Increase (decrease) in accounts payable and accrued
  liabilities.............................................               180,773       (1,656,478)        2,168,684
Common stock issued as compensation for services..........               323,938          263,586           266,800
Compensation expense for stock option grants and
  deferred salary increases    ...........................               489,668        1,044,183         1,374,710
                                                                    ------------      -----------      ------------
Net cash used in operating activities.....................            (2,262,120)        (723,213)      (14,586,222)

Cash flows from investing activities
Investment in marketable securities.......................           (20,106,837)     (47,608,270)      (16,194,994)
Proceeds from sale of marketable securities...............            31,783,317       45,870,396         4,718,162
Additions to property and equipment.......................              (196,910)      (1,066,758)       (1,350,850)
Proceeds from sale of property............................                     -            7,432            14,343
Expenditures for patents and proprietary technology.......              (265,435)        (770,262)         (305,135)
Investment in affiliated companies........................            (6,702,299)        (331,280)          652,698
Minority interest in affiliated companies.................                     -          215,407                 -
                                                                    ------------      -----------      ------------
Net cash provided by (used in) investing activities.......             4,511,836       (3,683,335)      (12,465,776)

Cash flows from financing activities
Principal payments under installment purchase and
  capital lease obligations...............................                     -          (39,507)          (16,137)
Proceeds from issuance of common stock....................             1,668,211        5,885,573        21,060,912
Cost of common stock issuance.............................                     -             (152)         (757,877)
Cash to Agritope..........................................            (7,206,196)               -                 -
                                                                    ------------      -----------      ------------
Net cash (used in) provided by financing activities.......            (5,537,985)       5,845,914        20,286,898

Net (decrease) increase in cash and cash equivalents......            (3,288,269)       1,439,366        (6,765,100)
Cash and cash equivalents at beginning of year............             5,699,263        4,259,897        11,024,997
                                                                    ------------      -----------      ------------
Cash and cash equivalents at end of year (Note 3).........         $   1,934,480     $  5,699,263     $   4,259,897
</TABLE>

The accompanying notes are an integral part of these statements.


                                     - 28 -
<PAGE>


NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

NOTE 1         THE COMPANY

Epitope,  Inc. (the "Company" or "Epitope") is an Oregon company incorporated in
1981.  Epitope  develops and markets oral specimen  collection  kits and related
diagnostic tests for the detection of the Human  Immunodeficiency Virus ("HIV"),
the cause of Acquired Immune Deficiency Syndrome ("AIDS"), and for the detection
of other medical  conditions and analytes.  The Company markets the device under
the brand name EpiScreen in the United States and in certain  foreign  countries
for use in screening life insurance  applicants and under the brand name OraSure
for use in the public health and medical professional  markets. The Company also
conducts joint research and development projects under contracts and grants.

See Note 3, Discontinued Operations, below.

NOTE 2         SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES

Basis  of  Presentation.  The  accompanying  consolidated  financial  statements
include  the  accounts of the Company  and its wholly  owned  subsidiaries.  All
significant  intercompany  balances and  transactions  have been  eliminated  in
consolidation.   Assets  and  liabilities  of  majority-owned  subsidiaries  are
included in these statements.  Minority-owned investments and joint ventures are
accounted for using the equity method.

Cash and Cash  Equivalents;  Marketable  Securities.  The Company  considers all
highly liquid investments with maturities at time of purchase of three months or
less to be cash  equivalents.  At  September  30,  1997,  marketable  securities
consisted of  commercial  paper and U.S.  Treasury  securities  with an original
maturity  period  greater than three months,  but generally less than 12 months.
The Company's  policy is to invest its excess cash in  securities  that maximize
(a) safety of principal,  (b) liquidity for operating  needs,  and (c) after-tax
yields.

Pursuant to Statement of Financial Accounting Standards No. 115, "Accounting for
Certain  Investments in Debt and Equity Securities," the Company has categorized
all  of its  investments  as  available-for-sale  securities  and,  accordingly,
unrealized gains and losses on such investments,  if material,  are carried as a
separate  component of  shareholders'  equity.  Such unrealized gains and losses
were immaterial as of September 30, 1997 and 1996.

Trade Accounts  Receivable.  Accounts  receivable are stated net of an allowance
for doubtful accounts of $32,284 and $6,872, respectively, at September 30, 1997
and 1996.

Inventories.  Inventories  are  recorded  at the lower of  standard  cost (which
approximates  actual cost on a first-in,  first-out basis) or market.  Inventory
components are summarized as follows:

<TABLE>
SEPTEMBER 30                                                                         1997                   1996
<S>                                                                               <C>                  <C>
Raw materials..........................................................           $   296,432          $    522,824
Work-in-process........................................................               343,585               389,642
Finished goods.........................................................               670,175               192,882
Supplies...............................................................                14,455                52,582
                                                                                   ----------            ----------
                                                                                  $ 1,324,647           $ 1,157,930
</TABLE>

Depreciation and Capitalization  Policies.  Property and equipment are stated at
cost less accumulated depreciation. Expenditures for repairs and maintenance are
charged  to  operating  expense  as  incurred.  Expenditures  for  renewals  and
betterments are capitalized.

Depreciation and amortization of property and equipment are calculated primarily
under the  straight-line  method over the estimated  lives of the related assets
(three to seven years). Leasehold improvements are amortized over the shorter of
estimated useful lives or the terms of the related leases.  When assets are sold
or  otherwise  disposed  of, cost and the related  accumulated  depreciation  or
amortization  are removed from the accounts  and any  resulting  gain or loss is
included in operations.


                                     - 29 -
<PAGE>


Accounting  for  Long-Lived  Assets.  The  Company   periodically   reviews  its
long-lived assets for impairment or as events or circumstances indicate that the
carrying amount of long-lived  assets may not be  recoverable.  If the estimated
net cash flows are less than the carrying amount of the long-lived  assets,  the
Company  recognizes  an  impairment  loss in an amount  necessary  to write down
long-lived  assets to fair value as determined from expected  discounted  future
cash flows.  This  accounting  policy is consistent  with Statement of Financial
Accounting  Standards  No. 121,  "Accounting  for the  Impairment  of Long-Lived
Assets  and  for  Long-Lived  Assets  to be  Disposed  Of."  There  has  been no
significant impact to the Company's  financial position or results of operations
as the carrying amount of all long-lived assets is considered recoverable.

Patents  and  Proprietary  Technology.   Direct  costs  associated  with  patent
submissions  and acquired  technology are  capitalized  and amortized over their
minimum estimated economic useful lives, generally five years.

Amortization and accumulated amortization are summarized as follows:

<TABLE>
                                                                     1997         1996         1995
<S>                                                               <C>          <C>          <C>
Amortization expense for the year ended September 30......        $ 209,180    $ 172,095    $ 130,313
Accumulated amortization at September 30..................          830,290      621,110      449,015
</TABLE>

Fair Value of Financial Instruments.  The carrying amounts for cash equivalents,
accounts receivable,  and accounts payable approximate fair value because of the
immediate or short-term maturity of these financial instruments.

Revenue  Recognition.  Product  revenues are generally  derived from the sale of
products and are  recognized  as revenue when the related  products are shipped.
Grant  and  contract   revenues   include  funds  received  under  research  and
development  agreements with various  entities.  Such revenues are recognized in
accordance with the contract terms.

Research and Development. Research and development expenditures are comprised of
those costs  associated with the Company's own ongoing  research and development
activities  including  the costs to prepare  for,  obtain and  compile  clinical
studies  and  other   information  to  support  product  license   applications.
Expenditures  for research and  development  also include costs  incurred  under
contracts to develop certain  products,  including those contracts  resulting in
grant and contract revenues.  All research and development costs are expensed as
incurred.

Shared Services. Certain corporate overhead services such as accounting,  annual
meeting  costs,  annual  report  preparation,   audit,   executive   management,
facilities,  finance, general management, human resources,  information systems,
investor  relations,  legal  services,  payroll and SEC filings are  provided by
Epitope on a  centralized  basis for the benefit of the  Company's  subsidiaries
("Shared  Services").  Such expenses have been allocated to the  subsidiaries in
the accompanying  financial  statements using activity  indicators which, in the
opinion of  management,  represent  a  reasonable  measure of the  subsidiaries'
utilization  of such  Shared  Services.  These  activity  indicators,  which are
reviewed  periodically  and adjusted to reflect changes in utilization,  include
number of employees, number of computers, and level of expenditures. The related
subsidiaries'  operating  results are included in discontinued  operations.  See
Note 3, Discontinued  Operations.  Selling,  general and administrative expenses
have been reduced by Shared Services  allocated to the subsidiaries  included in
discontinued operations of: $1,402,895,  $1,069,249 and $1,892,371 for the years
ended September 30, 1997, 1996 and 1995, respectively.

Income  Taxes.  The  Company  accounts  for certain  revenue  and expense  items
differently for income tax purposes than for financial reporting purposes. These
differences  arise principally from methods used in accounting for stock options
and depreciation rates. The Company accounts for income taxes under Statement of
Financial  Accounting  Standards No. 109,  "Accounting for Income Taxes," ("SFAS
109") which  requires the use of the asset and liability  method for  accounting
for income  taxes.  Under SFAS 109,  deferred  tax  assets and  liabilities  are
recognized based on temporary  differences  between the financial  statement and
the tax bases of assets and  liabilities  using  enacted tax rates in effect for
the year in which the temporary differences are expected to reverse.


                                     - 30 -
<PAGE>


Stock-Based  Compensation.  In October 1995, the Financial  Accounting Standards
Board issued Statement of Financial  Accounting  Standards No. 123,  "Accounting
for Stock-Based Compensation" ("SFAS 123"). SFAS 123 allows companies which have
stock-based compensation arrangements with employees to adopt a fair-value basis
of accounting  for stock options and other equity  instruments or to continue to
apply the existing  accounting rules under  Accounting  Principles Board Opinion
No.  25,  ("APB  25")  "Accounting  for  Stock  Issued to  Employees,"  but with
additional financial statement  disclosure.  The Company has elected to continue
to  account  for  its  stock-based  compensation  under  APB  25.  See  Note  5,
Shareholders' Equity.

Income (Loss) Per Share.  Income  (loss) per share has been  computed  using the
weighted  average number of shares of common stock and common stock  equivalents
outstanding during the period. Common stock equivalents consist of the number of
shares issuable upon exercise of outstanding  warrants,  options and convertible
notes less the number of shares  assumed to have been purchased for the treasury
with the proceeds from such exercise. Common stock equivalents are excluded from
the computation if their effect is anti-dilutive.  Primary and fully diluted net
income (loss) per share are the same.

In February 1997, the Financial  Accounting  Standards Board issued Statement of
Financial  Accounting Standards No. 128, "Earnings Per Share" ("SFAS 128"). This
new standard is effective for interim and annual  periods  ending after December
15, 1997. SFAS 128 will require the reporting of "basic" and "diluted"  earnings
per share ("EPS") instead of "primary" and "fully diluted" EPS as required under
current accounting principles. Basic EPS eliminates the common stock equivalents
considered in calculating  primary EPS.  Diluted EPS is similar to fully diluted
EPS.

Supplemental  Profit  and  Loss  Information.   In  September  1995,  management
announced a  company-wide  reduction  in work force  whereby 48  employees  were
terminated.  The Company  charged  $607,000 to 1995  results of  operations  for
severance  payments and related  expenses of this  program.  As of September 30,
1996,  $55,000  of  these  charges  remained  accrued  and are  included  in the
accompanying balance sheets of the Company under the caption "Salaries, benefits
and other  accrued  liabilities."  There were no such  accruals  remaining as of
September 30, 1997.

Management Estimates. The preparation of financial statements in conformity with
generally accepted  accounting  principles requires management to make estimates
relating  to  assumptions  that  affect  the  reported  amounts  of  assets  and
liabilities  and disclosure of contingent  assets and liabilities at the date of
the  financial  statements  as well as the  reported  amounts  of  revenues  and
expenses  during the  reporting  period.  Actual  results  could vary from these
estimates.  The Company has a contingent  liability with regard to the guarantee
of a loan to a former  subsidiary (A&W) through Wells Fargo Bank, NA. Because of
the various  collateral and corporate and personal  guarantees that also back up
this line of credit, the Company feels that the likelihood that the Company will
sustain  any loss  under  this  agreement  is remote  (see Note 3,  Discontinued
Operations).

Reclassifications. Certain reclassifications have been made to prior years' data
to conform with the current year's presentation.  These reclassifications had no
impact on previously reported results of operations or shareholders' equity.

NOTE 3         DISCONTINUED OPERATIONS

Agritope.  Throughout the period presented,  Agritope,  Inc.  ("Agritope") was a
wholly owned  subsidiary of Epitope acquired in 1987.  Agritope  consists of two
units:  Agritope  Research and Development  ("Agritope R&D") and Vinifera,  Inc.
("Vinifera").  Agritope R&D uses  biotechnology  in the development of new fruit
and vegetable plant varieties for sale to the fresh produce  industry.  To date,
Agritope has not completed  commercialization  of this technology.  A portion of
the research and  development  efforts  conducted by Agritope has been performed
under  various  research  grants  and  contracts.  Vinifera  is  engaged  in the
grapevine  propagation and distribution  business.  During 1995, Vinifera was in
the development  stage and generated minimal product sales.  Vinifera  commenced
commercial  stage operations in 1996.  Agritope's  results of operations and net
assets are presented as discontinued operations in the accompanying consolidated
financial  statements for all periods  presented.  All  intercompany  loans from
Epitope to Agritope  have been  reflected as capital  contributions  to Agritope
consistent  with the  separation  agreement  between  Epitope and Agritope dated
December 1, 1997. The 1997 loss from


                                     - 31 -
<PAGE>


discontinued  operations  of Agritope  includes  an accrual of $1.2  million for
Agritope's operating losses, from October 1, 1997 to December 1, 1997, and costs
of the spin-off of Agritope  which is expected to occur in late  December  1997.
The separation  agreement  provides that, all net expenses of Agritope beginning
December 1, 1997, will be borne by Agritope.

Andrew and  Williamson  Sales,  Co. On December 12,  1996,  a subsidiary  of the
Company  completed a merger with  Andrew and  Williamson  Sales,  Co.  (A&W),  a
producer and wholesale  distributor  of fresh and frozen  fruits and  vegetables
based in San  Diego,  California.  Under the terms of the  merger,  the  Company
issued  520,000  shares of common stock of Epitope,  Inc. in exchange for all of
the outstanding common stock of A&W.

On May 27, 1997, in  accordance  with the terms of a rescission  agreement,  the
former  shareholders  of A&W returned the 520,000 shares of Epitope common stock
they received,  and Epitope returned all of the outstanding shares of A&W common
stock. Epitope also received A&W preferred stock in satisfaction of intercompany
loans  made to A&W  between  December  12,  1996 and  March 19,  1997.  This A&W
preferred  stock  carries  a  $5.7  million  liquidation  preference,   dividend
preferences, and various redemption features.

A&W's  results of  operations  for the period from December 13, 1996 through May
27, 1997 are presented in the accompanying  financial statements as discontinued
operations.  The estimated loss on disposal of $8.4 million results from several
factors,  including a $1.8 million  reduction  in market price of the  Company's
stock from the purchase date to the rescission  date, a $5.7 million discount of
the A&W preferred  stock to its estimated net present value as compared with the
face  amount  of the  loans  made to  A&W,  the  write-off  of  $633,000  in A&W
acquisition  costs,  and the accrual of $262,000 in estimated  costs  associated
with the rescission.

THE COMPONENTS OF AGRITOPE'S NET ASSETS ARE SUMMARIZED AS FOLLOWS:
<TABLE>
SEPTEMBER 30                                                                         1997              1996
<S>                                                                               <C>              <C>
Cash.......................................................................       $     4,384      $   476,512
Trade accounts receivable, net.............................................           617,359          264,986
Inventories................................................................         2,081,295          509,745
Other current assets.......................................................           281,778           33,149
                                                                                   ----------       ----------
Total current assets.......................................................         2,984,816        1,284,392

Property and equipment, net................................................         2,749,788        1,286,197
Patents and proprietary technology, net....................................         1,276,692          510,244
Investment in affiliates...................................................           246,962        2,448,623
Other assets...............................................................            26,797          140,513
                                                                                   ----------       ----------
                                                                                    7,285,055        5,669,969

Convertible notes due June 1997............................................                 -        3,620,003
Other current liabilities..................................................         1,326,008          826,952

Long-term liabilities......................................................         1,196,321          215,407
Accrued losses.............................................................         1,200,000                -
                                                                                   ----------       ----------
Net assets of discontinued operations......................................       $ 3,562,726      $ 1,007,607
</TABLE>

THE  SUMMARIZED  STATEMENTS OF OPERATIONS  FOR AGRITOPE AND  SUBSIDIARIES  IS AS
FOLLOWS:
<TABLE>
SEPTEMBER 30                                                                    1997                 1996                1995

<S>                                                                        <C>                   <C>                <C>
Revenues..............................................................     $  1,551,190          $   585,485        $  2,109,688
Operating costs and expenses..........................................        6,088,883            2,821,397           9,920,166
Other income (expense), net...........................................       (4,427,275)            (265,356)           (234,740)
Minority interest in subsidiary net loss..............................          274,369                    -                   -
                 -
Net loss from operations..............................................       (8,690,599)          (2,501,268)         (8,045,218)
</TABLE>


                                     - 32 -
<PAGE>


Bank Line of Credit.  A&W maintains a $6,500,000  revolving bank line of credit.
The line is secured  by A&W's  accounts  receivable,  inventory  and  equipment.
Epitope has agreed to guarantee  the line of credit and any  succeeding  line of
credit  through  November 1, 1998. In addition,  the principals of A&W have each
personally  guaranteed  the  loan.  The  Company's  guarantee  contains  various
financial  covenants  including  minimum tangible net worth levels.  The balance
outstanding under the line was $250,000 at September 30, 1997.

Long Term Debt. In November 1996, Epitope exchanged  $3,380,000 principal amount
of Agritope convertible notes for 250,367 shares of common stock of Epitope at a
reduced  exchange  price of $13.50 per share.  The exchange price had previously
been fixed at $19.53 per share.  Accordingly,  Agritope  recognized  a charge to
results  of  operations  of  $1,216,654  in the first  quarter  of  fiscal  1997
representing  the  conversion   expense.   In  conjunction  with  the  exchange,
unamortized debt issuance costs of $86,134 related to such notes were recognized
as equity  issuance  costs during  1997.  Concurrent  with the note  conversion,
Epitope made a $4,529,009  capital  contribution to Agritope.  On June 30, 1997,
Agritope paid in full the remaining $240,000 principal amount outstanding.

NOTE 4         PROPERTY AND EQUIPMENT

Property and equipment are summarized as follows:

<TABLE>
SEPTEMBER 30                                                                        1997                   1996
<S>                                                                              <C>                   <C>
Research and development laboratory equipment..........................          $  1,096,425          $  1,056,883
Manufacturing equipment................................................             1,389,304             1,291,546
Office furniture and equipment.........................................             1,772,698             1,899,948
Leasehold improvements.................................................             1,102,895             1,084,660
Construction in progress...............................................               109,380               134,557
                                                                                  -----------           -----------
                                                                                    5,470,702             5,467,594
Less accumulated depreciation and amortization.........................            (4,269,714)           (3,924,837)
                                                                                  -----------           -----------
                                                                                 $  1,200,988          $  1,542,757
</TABLE>

NOTE 5         SHAREHOLDERS' EQUITY

Authorized  Capital  Stock.  The  Company's  amended  articles of  incorporation
authorize  1,000,000  shares of preferred stock and 30,000,000  shares of common
stock. The Company's Board of Directors has authority to determine  preferences,
limitations and relative rights of the preferred stock.

Common  Stock  Reserved for Future  Issuance.  As of  September  30,  1997,  the
following  shares  of the  Company's  common  stock  were  reserved  for  future
issuance, as more fully described below:

<TABLE>
PURPOSE                                                                                   SHARES
<S>                                                                                     <C>
Outstanding warrants............................................................        2,000,640
Outstanding stock options.......................................................        3,499,865
Employee Stock Purchase Plan subscriptions......................................           76,460
                                                                                        ---------
                                                                                        5,576,965
</TABLE>


                                     - 33 -
<PAGE>


<TABLE>
Common Stock  Warrants.  As of September 30, 1997, the following  warrants to purchase  shares of common stock were
outstanding:
DATE OF ISSUANCE                                               SHARES        PRICE *       EXPIRATION DATE
<S>                                                           <C>            <C>        <C>
September 26, 1991........................................      159,150      $16.00     September 30, 2000
December 23, 1992.........................................      988,390       18.50     September 30, 2000
July 20, 1993.............................................      375,000       20.00     September 30, 2000
August 1, 1993............................................      200,000       18.50     September 30, 2000
October 17, 1994..........................................       50,000       18.50     September 30, 2000
November 22, 1994.........................................      228,100       18.50     September 30, 2000
                                                              ---------
                                                              2,000,640
</TABLE>

* Beginning ten days after the Agritope spin-off, Epitope will allow exercise of
the  warrants at a price equal to 110  percent of the average  closing  price of
Epitope  common stock during the five trading days  beginning on the date of the
spin-off.

Stock Award  Plans.  The  Company's  1991 Stock Award Plan (the "1991 Plan") was
approved by the  shareholders  during 1991,  replacing the  Company's  Incentive
Stock Option Plan  ("ISOP").  The 1991 Plan provides for  stock-based  awards to
employees,  outside directors and members of scientific  advisory  committees or
other  consultants.  Awards  which may be  granted  under the 1991 Plan  include
qualified   incentive   stock  options,   nonqualified   stock  options,   stock
appreciation rights, restricted awards, performance awards and other stock-based
awards.

Under the terms of the 1991 Plan, qualified incentive stock options on shares of
common stock may be granted to eligible employees,  including  officers,  of the
Company at an exercise price not less than the fair market value of the stock on
the date of grant.  The maximum term during which any option may be exercised is
ten years  from the date of grant.  To date,  options  have  been  granted  with
four-year vesting schedules.

Options  issued to employees  under the ISOP were issued at prices not less than
the fair  market  value of a share of  common  stock on the date of  grant.  The
options are exercisable after one year from the date of grant at the rate of 25%
per year cumulatively and expire ten years from the date of grant.

The 1991 Plan also provides that nonqualified  options may be granted at a price
not less than 75% of the fair  market  value of a share of  common  stock on the
date of grant. The option term and vesting schedule of such awards may either be
unlimited or have a specified period in which to vest and be exercised.  For the
discounted   nonqualified   options  issued,   the  Company   amortizes,   on  a
straight-line  basis over the  vesting  period of the  options,  the  difference
between the exercise  price and the fair market value of a share of stock on the
date of grant.  As of September  30, 1997,  1,145,874  shares of Epitope  common
stock remain available for grant under the Company's stock award plans.

In October 1995, the Financial  Accounting  Standards Board issued  Statement of
Financial   Accounting   Standards   No.  123,   "Accounting   for   Stock-Based
Compensation"  ("SFAS 123").  SFAS 123 allows  companies which have  stock-based
compensation  arrangements  with  employees  to  adopt  a  fair-value  basis  of
accounting  for stock  options and other  equity  instruments  or to continue to
apply  the  existing  accounting  rules  under,  but with  additional  financial
statement  disclosure.  The Company  has  continued  to account for  stock-based
compensation  under  APB 25,  and  therefore,  SFAS 123 did not have a  material
impact on its financial position or results of operations.

Options  granted and  outstanding  under the  Company's  stock  option plans are
summarized as follows:

<TABLE>
                                        1997                        1996                           1995
                                 SHARES       PRICE          SHARES       PRICE            SHARES         PRICE
Outstanding at
<S>                            <C>        <C>              <C>        <C>                <C>          <C>
 beginning of period ......    3,365,726  $3.50 - 24.00    3,636,103  $1.09 - 24.00      3,483,432    $1.09 - 24.94
Granted....................    2,801,403   3.50 - 14.81      901,379   9.81 - 18.13        802,050    14.94 - 18.88
Exercised..................      (16,124)  7.25 - 14.81     (386,550)  1.09 - 17.13       (183,525)    1.84 - 22.50
Canceled...................   (2,651,140)  3.50 - 24.00     (785,206) 14.38 - 24.00       (465,854)    7.38 - 24.94
                               ---------   ------------    ---------  -------------      ---------   --------------
Outstanding at end of period   3,499,865  $3.50 - 20.38    3,365,726  $3.50 - 24.00      3,636,103    $1.09 - 24.00

Exercisable................    2,474,623  $3.50 - 20.38    2,302,212  $3.50 - 24.00      2,002,925    $1.09 - 24.00
</TABLE>


                                     - 34 -
<PAGE>


<TABLE>
                                    Number of        Weighted          Average Remaining
Exercise Price Range                Shares           Average Price              Contractual Life
- --------------------                ------           -------------              ----------------
<S>            <C>                    <C>                 <C>                            <C>
$3.50     -    $5.75                     55,950           $4.9172                        5.69
$6.38     -    $6.38                    825,000           $6.375                         8.27
$6.69     -    $7.06                     65,150           $6.968                         9.53
$7.25     -    $7.25                  2,175,503           $7.25                          7.57
$8.02     -    $20.38                   296,832           $13.72                         8.46
                                     ----------           ------                         ----
                                      3,418,435            $7.56                         7.83
</TABLE>

Options exercisable at September 30, 1997 totaled 2,474,623 shares at a weighted
average  exercise price of $7.65.  Options  available for grant at September 30,
1997 totaled 1,145,874.

Pursuant  to the 1991  Plan,  973 and 3,680  shares of  common  stock  were also
awarded  to  consultants  and  members  of  the  Company's  scientific  advisory
committees during 1996 and 1995, respectively.

Employee Stock Purchase Plans. In 1991, the shareholders  approved the Company's
adoption of the 1991  Employee  Stock  Purchase  Plan ("1991  ESPP")  covering a
maximum of 100,000  shares of common  stock for  subscription  over two offering
periods.  The purchase price for stock purchased under the 1991 ESPP for each of
the two 24-month  subscription  periods was the lesser of 85% of the fair market
value of a share of common stock at the commencement of the subscription  period
or the fair market value at the close of each  subscription  period. An employee
may also  elect to  withdraw  at any time  during  the  subscription  period and
receive the amounts paid plus interest at the rate of 6%.

The 1993 Employee  Stock  Purchase Plan ("1993  ESPP"),  as amended and restated
effective  February 1, 1993,  covers a maximum of 500,000 shares of common stock
for  subscription  over  established  offering  periods.  The Company's Board of
Directors was granted authority to determine the number of offering periods, the
number of shares offered,  and the length of each period,  provided that no more
than three  offering  periods  (other than  Special  Offering  Subscriptions  as
described  below) may be set  during  each  fiscal  year of the  Company.  Other
provisions  of the 1993 ESPP are similar to the 1991 ESPP.  As of September  30,
1997,  76,460  shares of common stock were  subscribed  for during two offerings
under the 1993 ESPP.  Shares  subscribed for under these 1993 ESPP offerings may
be purchased over 24 months and have initial subscription prices of $ 8.77 and $
6.00 per share for the various  offerings.  During the year ended  September 30,
1997,  2,472 shares were issued at prices ranging from $8.77 to $12.33 under the
1993 ESPP.

The 1993 ESPP was amended to allow the Company,  at its  discretion,  to provide
Special  Offering   Subscriptions  whereby  an  employee's  annual  increase  in
compensation could be deferred for a one-year period. At the end of the one-year
period,  the employee can elect to receive the deferred  compensation  amount in
the form of cash or shares of the Company's common stock. The purchase price for
stock issued under a Special  Offering  Subscription is the lesser of 85% of the
fair market  value of a share of common  stock on the first day of the  calendar
month the  employee's  increase  was  effective  or the fair market value at the
close of the one-year  subscription period. 5,569 Special Offering  Subscription
shares were issued to  employees  during 1995 at an average  price of $15.26 per
share.

The Company has elected to account for its  stock-based  compensation  under the
provisions of APB 25, however, as required by SFAS 123, the Company has computed
for pro forma  disclosure  purposes the value of options granted during 1997 and
1996  using  the  Black-Scholes  option  pricing  model.  The  weighted  average
assumptions  used for  stock  option  grants  for 1997 and 1996 were a risk free
interest rate of 5.9 percent and 5.6 percent, respectively, an expected dividend
yield of 0 percent and 0 percent,  respectively, an expected life of 4.3 and 4.4
years,  respectively,  and an expected  volatility of 53 percent and 48 percent,
respectively. The weighted average assumptions used for ESPP rights for 1997 and
1996  were  a  risk  free   interest  rate  of  6.1  percent  and  5.4  percent,
respectively,   an  expected   dividend  yield  of  0  percent  and  0  percent,
respectively,  an  expected  life of 2 years and 2 years,  respectively,  and an
expected   volatility   of  63  percent  and  48  percent,   respectively.   The
weighted-average  fair value of ESPP  rights  granted in 1997 was  $248,700  and
$57,600 for ESPP rights granted in 1996.


                                     - 35 -
<PAGE>


Options  were  assumed  to be  exercised  upon  vesting  for  purposes  of  this
valuation.  Adjustments are made for options forfeited prior to vesting. For the
years ended  September 30, 1997 and 1996, the total value of the options granted
was  computed to be  $9,096,600  and  $6,638,200,  respectively,  which would be
amortized on a straight-line basis over the vesting period of the options.

If the Company had accounted  for these plans in  accordance  with SFAS 123, the
Company's net income and pro forma net income per share would have been reported
as follows:

<TABLE>
YEAR ENDED SEPTEMBER 30                                            1997                      1996

                                                   NET LOSS          NET LOSS           NET LOSS          NET LOSS
                                                                    PER SHARE                             PER SHARE
<S>                                            <C>                    <C>           <C>                    <C>
As reported.................................   $ (22,440,271)         $ (1.67)      $ (1,399,900)          $ (.11)
Pro forma...................................     (26,958,371)           (2.01)        (3,579,800)            (.28)
</TABLE>

The effects of applying SFAS 123 in providing pro forma  disclosure for 1997 and
1996 are not likely to be  representative  of the effects on reported net income
and earnings per share for future  years since  options vest over several  years
and additional awards are made each year.

NOTE 6            INCOME TAXES

As of September 30, 1997,  the Company had net operating loss  carryforwards  of
approximately $45.0 million and $42.0 million,  respectively,  to offset federal
and state  taxable  income.  Approximately  $6.9  million of the  Company's  net
operating loss carryforwards were generated as a result of deductions related to
the  exercise  of stock  options.  When  utilized,  such  carryforwards,  as tax
effected, will be reflected in the Company's financial statements as an increase
in  shareholders'  equity  rather than a reduction of the  provision  for income
taxes.

As of  September  30, 1997,  the Company had total gross  deferred tax assets of
approximately $21.3 million, consisting primarily of $17.0 million net operating
loss  carryforwards,  $1.7 million of deferred  compensation  and a $0.9 million
research and  development tax credit  carryforward.  No benefit for these assets
has been reflected in the accompanying consolidated financial statements as they
do not satisfy the recognition  criteria set forth in SFAS 109.  Accordingly,  a
valuation allowance of $21.3 million, representing a $4.6 million increase since
the prior fiscal year end, has been recorded.

The  expected  tax  benefit of  approximately  $4.4  million  for the year ended
September 30, 1997 is increased by approximately  $0.5 million for the effect of
state and local taxes (net of federal  impact)  and is reduced by  approximately
$4.6  million for the effect of the  increase in  valuation  allowance  and $0.3
million  for  other  permanent  differences  consisting  primarily  of  the  A&W
valuation difference write off.

The federal  and state net  operating  loss  carryforwards  available  to offset
future taxable income will expire as follows:

<TABLE>
                                                                                        LOSS CARRYFORWARDS
YEAR OF EXPIRATION                                                                 FEDERAL              OREGON
<S>                                                                            <C>                  <C>
1998...................................................................        $    22,000          $      ---
1999...................................................................            252,000              25,000
2000...................................................................            100,000             200,000
2001...................................................................            300,000              31,000
2002...................................................................            666,000                 ---
2003...................................................................          2,278,000           2,106,000
2004...................................................................          2,360,000           2,206,000
2005...................................................................          1,993,000           1,914,000
2006...................................................................          6,100,000           5,643,000
2007...................................................................          6,378,000           5,788,000


                                     - 36 -
<PAGE>


2008...................................................................          5,370,000           4,671,000
2009...................................................................          3,459,000           4,430,000
2010...................................................................          7,053,000           6,275,000
2011...................................................................            796,000             796,000
2012...................................................................          7,731,000           7,731,000
                                                                              ------------        ------------
                                                                               $44,858,000         $41,816,000

Significant components of Epitope's deferred tax asset were as follows:

SEPTEMBER 30
1997                               1996
Net operating loss carryforwards.......................................        $17,030,000         $13,627,000
Deferred compensation..................................................          1,707,000           1,504,000
Research and experimentation credit carryforwards......................            888,000             812,000
Accrued expenses.......................................................            868,000             302,000
Other..................................................................            850,000             436,000
                                                                              ------------        ------------

Gross deferred tax assets..............................................         21,343,000          16,681,000
Valuation allowance....................................................        (21,343,000)        (16,681,000)
                                                                              ------------        ------------
Net deferred tax asset.................................................        $      ----         $      ----
</TABLE>

NOTE 7   RESEARCH AND DEVELOPMENT ARRANGEMENTS

In February  1995, the Company  entered into a  development,  license and supply
agreement  with  SmithKline  Beecham,  plc ("SB")  pursuant to which the Company
conducted  research  and  development  projects  funded by SB. In July 1997,  SB
terminated the agreement.  Revenues from research and  development  arrangements
are included in the accompanying consolidated statements of operations under the
caption "Grants and Contracts."

NOTE 8   DISTRIBUTION AND SUPPLY CONTRACTS

The Company has entered into several contractual  arrangements,  including those
discussed  in the  following  paragraphs,  for  distribution  of  certain of its
products to customers.

The  Company  continues  to maintain  supply and  distribution  agreements  with
Organon  Teknika  Corporation  ("Organon  Teknika"),   whereby  Organon  Teknika
supplies the Company's  antigen  requirements  and  exclusively  distributes the
Company's EPIblot HIV confirmatory tests ("EPIblot") on a worldwide basis. As of
April  1,  1994,  the  Company  renewed  the  agreements  which  had an  initial
termination  date of March 31, 1997 (with  successive  one-year  renewal periods
thereafter) and include pricing incentives based on volumes purchased by Organon
Teknika  and  penalties  for  failure to purchase  specified  minimum  quarterly
volumes.  In 1997, the agreement was extended for another one-year  period.  For
the years  ended  September  30,  1997,  1996 and 1995,  respectively,  revenues
generated from sales of EPIblot to Organon Teknika were  $1,791,290,  $1,539,164
and $1,808,431, including export sales of $15,750, $62,539 and $72,369.

LabOne, Inc. (previously Home Office Reference Laboratory,  Inc.) purchases oral
specimen  devices  from the Company for use in  insurance  testing in return for
non-exclusive  distribution  rights in the United  States  and  Canada  under an
agreement which expires on March 13, 2000, with an automatic  five-year renewal,
unless either party  notifies the other of intent not to renew at least 180 days
prior to the initial  expiration  date. For the years ended  September 30, 1997,
1996 and 1995,  respectively,  revenues  generated from product sales to LabOne,
Inc.  were  $3,194,698,  $1,327,544  and  $525,628  including  export  sales  of
$597,000, $394,747 and $58,500.

SB had an exclusive  agreement to market the Company's oral specimen  collection
device  worldwide,  except in several  foreign  countries  and to the  insurance
industry  in the U.S.,  Canada  and  Japan.  In July  1997,  SB  terminated  its
development, license and supply agreement with Epitope. As a result, the Company
acquired  marketing rights for OraSure from SB. During the transition  period in
August and September of 1997, SB continued to market the OraSure  testing system
to the medical  community.  Beginning in October  1997,  the product is marketed
through Epitope's direct sales force.


                                     - 37 -
<PAGE>


In 1995, SB made an initial license fee payment of $1 million to the Company and
committed an  additional  license fee of $4 million to be paid upon FDA approval
of a pending  request  to amend the  labeling  of the  Company's  oral  specimen
collection  device to  indicate a two-year  shelf life.  In April 1996,  the FDA
granted the  Company's  request for extended  dating and SB disbursed $4 million
plus  interest from escrow.  Accordingly,  the Company  recognized  income of $5
million in 1996 operating results.


NOTE 9    COMMITMENTS

The Company leases office,  manufacturing,  warehouse and laboratory  facilities
under  operating  lease  agreements  which require  minimum  annual  payments as
follows:

YEAR ENDING SEPTEMBER 30
<TABLE>
<S>                                                                                                     <C>
1998..............................................................................................      $ 345,576
1999..............................................................................................        346,356
2000..............................................................................................        109,992
                                                                                                        ---------
                                                                                                        $ 801,924
</TABLE>

Under the agreements for the lease of its office and laboratory facilities,  the
Company is obligated to the lessor for its share of certain  expenses related to
the use, operation,  maintenance and insurance of the property.  These expenses,
payable  monthly in addition to the base rent,  are not  included in the amounts
shown above.  Rent expense  aggregated  $409,970,  $538,665 and $547,930 for the
years ended September 30, 1997, 1996 and 1995, respectively.

NOTE 10  PROFIT SHARING AND SAVINGS PLAN

The Company  established a profit  sharing and deferred  salary  savings plan in
1986 and restated the plan in 1991. All employees are eligible to participate in
the plan. In addition, the plan permits certain voluntary employee contributions
to be excluded from the employees'  current  taxable income under the provisions
of  Internal  Revenue  Code  Section  401(k)  and  the  regulations  thereunder.
Effective  October 1, 1991, the Company replaced a discretionary  profit sharing
provision with a matching contribution (either in cash, shares of Epitope common
stock,  or  partly  in  both  forms)  equal  to  50%  of  an  employee's   basic
contribution,  not to exceed 2.5% of an  employee's  compensation.  The Board of
Directors  has the  authority to increase or decrease the 50% match at any time.
During  1997,  1996 and 1995,  respectively,  the Company  contributed  $101,737
(11,459  shares,  totaling  $101,721 and the remainder in cash),  $73,315 (4,653
shares  totaling  $73,279 and the  remainder in cash) and $97,631  (5,562 shares
totaling  $97,607 and the remainder in cash).  As of September 30, 1997,  27,832
shares of Epitope common stock are held by the plan.


                                     - 38 -
<PAGE>


NOTE 11   GEOGRAPHIC AREA INFORMATION

The  Company's  products  are all  included  in the  medical  products  industry
segment.  See Note 1 for a description of the Company's business.  The Company's
products are sold principally in the United States, Canada and Europe. Operating
loss represents revenues less operating  expenses.  In computing operating loss,
allocated corporate  administration expenses have been included;  however, other
income and expense items such as interest  expense,  miscellaneous  income,  and
other charges have not been added or deducted.

IN THOUSANDS
<TABLE>
GEOGRAPHIC                   REVENUES                     OPERATING LOSS                   IDENTIFIABLE ASSETS
AREAS             1997         1996      1995      1997         1996         1995       1997       1996      1995
United
<S>              <C>         <C>        <C>     <C>          <C>         <C>         <C>        <C>       <C>
States........   $ 8,569     $ 4,903    $ 2,630 $ (4,964)    $ (5,287)   $ (11,608)  $ 17,012   $ 29,784  $ 26,142
Canada........       608         404         78                     -            -                     -         -
Latin
America.......         4         100          -                     -            -                     -         -
Europe........        49          65         72                     -            -                     -         -
Other.........       130         122         76                     -                       -          -         -
                  ------      ------     ------   ------      -------     --------    -------    -------   -------
                 $ 9,360     $ 5,594    $ 2,856 $ (4,964)    $ (5,287)   $ (11,608)  $ 17,012    $29,784  $ 26,142
</TABLE>



No schedules are included with the foregoing  financial  statements  because the
required information is inapplicable or is presented in the financial statements
or related notes thereto.

(a)(3) Exhibits.

See Index to Exhibits following the signature pages of this report.

(b)      Reports on Form 8-K.  

Current  report on Form 8-K dated  July 28,  1997,  reporting  under  Item 5 the
Company's  intention  to  spin-off  Agritope  and  the  termination  of  the  SB
Agreement.

Current report on Form 8-K dated September 12, 1997,  reporting under Item 5 the
extension and repricing of outstanding warrants.



                                     - 39 -

<PAGE>


                                   SIGNATURES

Pursuant  to the  requirements  of the  Securities  Exchange  Act of  1934,  the
Registrant  has duly  caused  this  report  to be  signed  on its  behalf by the
undersigned, thereunto duly authorized, on December 24, 1997.

                            EPITOPE, INC.

                            By /s/ Gilbert N. Miller
                            Gilbert N. Miller
                            Executive Vice President and Chief Financial Officer

Pursuant to the requirements of the Securities Exchange Act of 1934, this report
has been signed on December 24, 1997, by the following  persons on behalf of the
Registrant and in the capacities indicated.

                  SIGNATURE                          TITLE

         *JOHN W. MORGAN            President and Chief Executive Officer
         John W. Morgan             (Principal Executive Officer)

         /S/ GILBERT N. MILLER      Executive Vice President and
         Gilbert N. Miller          Chief Financial Officer
                                    (Principal Financial Officer and Principal
                                    Accounting Officer)

         *W. CHARLES ARMSTRONG      Director
         W. Charles Armstrong

         *RICHARD K. DONAHUE        Director
         Richard K. Donahue

         *ADOLPH J. FERRO           Director
         Adolph J. Ferro

         *R. DOUGLAS NORBY          Director
         R. Douglas Norby

         *MICHAEL J. PAXTON         Director
         Michael J. Paxton

         *ROGER L. PRINGLE          Director
         Roger L. Pringle

         *G. PATRICK SHEAFFER       Director
         G. Patrick Sheaffer

         * /S/ GILBERT N. MILLER
         Gilbert N. Miller
         (Attorney-in-Fact)


                                     - 40 -
<PAGE>


                                INDEX TO EXHIBITS
Exhibit
Number            Exhibit
- ------            -------
2.1               Acquisition and Merger Agreement among  Registrant,  Thamscoe,
                  Inc.,  Andrew and Williamson  Sales, Co., and the shareholders
                  of Andrew and Williamson  Sales,  Co., dated November 6, 1996.
                  Incorporated  by  reference  to Exhibit 2 to the  Registrant's
                  Current Report on Form 8-K dated November 6, 1996.

2.2               Settlement Agreement and Release among Epitope, Inc., Keith R.
                  Andrew and Kevin S.  Andrew as  co-trustees  under the Fred W.
                  and Virginia S. Andrew 1990 Revocable  Living Trust,  Keith R.
                  Andrew,  individually,  Fred L. Williamson, Fred M. Williamson
                  and  Andrew  and  Williamson  Sales,  Co.,  dated May 4, 1997.
                  Incorporated by reference to Exhibit 10.1 of the  Registrant's
                  Quarterly  Report on Form 10-Q for the fiscal quarterly period
                  ended March 31, 1996 ("March 1996 10-Q").

2.3               Separation Agreement between Epitope, Inc. and Agritope,  Inc,
                  dated December 1, 1997

3.1               Restated Articles of Incorporation, as amended, of Registrant.
                  Incorporated  by  reference  to Exhibit 3 to the  Registrant's
                  Registration  Statement  on Form 8-A filed  December  26, 1997
                  (File No. 000-15337).

3.2               Restated Bylaws of Registrant.

4.1               Stock  Purchase  Agreement  dated  November  9, 1990,  between
                  certain  investors and  Registrant.  Copies of the  agreements
                  with  individual  investors shall be filed with the Commission
                  upon  request  pursuant  to  Instruction  2  of  Item  601  of
                  Regulation S-K ("Item 601,  Instruction  2").  Incorporated by
                  reference to Exhibit 4.2 to the Registrant's  Annual Report on
                  Form 10-K for the year  ended  September  30,  1994 (the "1994
                  10-K").

4.2               Unit Purchase  Agreement  dated September 1991 between certain
                  investors  and  Registrant.  Copies  of  the  agreements  with
                  individual  investors  shall be filed with the Commission upon
                  request pursuant to Item 601,  Instruction 2.  Incorporated by
                  reference to Exhibits 4.1 and 4.2 to the Registrant's  Current
                  Report on Form 8-K dated September 17, 1991.

4.3               Note Purchase  Agreement dated June 10, 1992,  among Agritope,
                  Inc.,  Registrant,  and  certain  investors.   Copies  of  the
                  agreements with  individual  investors shall be filed with the
                  Commission upon request  pursuant to Item 601,  Instruction 2.
                  Incorporated  by reference to Exhibit 4.2 to the  Registrant's
                  Quarterly  Report on Form 10-Q for the fiscal quarterly period
                  ended June 30, 1992.

4.4               Warrant  Purchase  Agreement  dated as of November  25,  1992,
                  between  certain  investors  and  Registrant.  Copies  of  the
                  agreements with  individual  investors shall be filed with the
                  Commission upon request  pursuant to Item 601,  Instruction 2.
                  Incorporated  by reference to Exhibit 4.5 to the  Registrant's
                  Annual  Report on Form 10-K for the year ended  September  30,
                  1992 (the "1992 10-K").

4.5               1993 Technology  Transfer Warrant Issuance  Agreement dated as
                  of June 15, 1993,  between  certain  investors and Registrant.
                  Copies of the agreements  with  individual  investors shall be
                  filed with the Commission  upon request  pursuant to Item 601,
                  Instruction 2. Incorporated by reference to Exhibit 4.3 to the
                  Registrant's Registration Statement on Form S-3 (No. 33-68510)
                  ("Registration Statement No. 33-68510").

4.6               Form of Letter dated August 1, 1993, from Registrant regarding
                  modification  of the  terms  of the 1993  Technology  Transfer
                  Warrants.   Incorporated   by  reference  to  Exhibit  4.5  to
                  Registration Statement No. 33-68510.

4.7               1993  Warrant  Purchase  Agreement  dated as of July 6,  1993,
                  between  certain  investors  and  Registrant.  Copies  of  the
                  agreements with  individual  investors shall be filed with the
                  Commission upon request  pursuant to Item 601,  Instruction 2.
                  Incorporated  by  reference  to  Exhibit  4.6 to  Registration
                  Statement No. 33-68510.


                                     - 41 -
<PAGE>


4.8               Notice  to   warrantholders   and  current   form  of  warrant
                  certificate  for warrants  issued in September  1991 offering,
                  reflecting  extension  of  expiration  date.  Incorporated  by
                  reference to Exhibit 4.1 to the Registrant's Current Report on
                  Form 8-K dated September 12, 1997.

4.11              Notice  to   warrantholders   and  current   form  of  warrant
                  certificate  for warrants  issued in December  1992  offering,
                  reflecting  extension  of  expiration  date.  Incorporated  by
                  reference to Exhibit 4.2 to the Registrant's Current Report on
                  Form 8-K dated September 12, 1997.

4.12              Notice  to   warrantholders   and  current   form  of  warrant
                  certificate   for  warrants  issued  in  July  1993  offering,
                  reflecting  extension  of  expiration  date.  Incorporated  by
                  reference to Exhibit 4.3 to the Registrant's Current Report on
                  Form 8-K dated September 12, 1997.

4.13              Notice  to   warrantholders   and  current   form  of  warrant
                  certificate  for  warrants  issued  in August  1993  offering,
                  reflecting  extension  of  expiration  date.  Incorporated  by
                  reference to Exhibit 4.4 to the Registrant's Current Report on
                  Form 8-K dated September 12, 1997.

10.1              Incentive  Stock  Option  Plan  of  Registrant,   as  amended.
                  Incorporated by reference to Exhibit 10.1 to the 1994 10-K.*

10.2              Amended and Restated Epitope, Inc., 1991 Stock Award Plan.*

10.3              Agritope,   Inc.,  1992  Stock  Award  Plan.  Incorporated  by
                  reference to Exhibit 10.3 to the 1992 10-K.*

10.4              Form of  Nonqualified  Stock Option  Agreement to be issued to
                  certain  officers  and  directors  of  Registrant  pursuant to
                  Agritope, Inc., 1992 Stock Award Plan.*

10.5              Lease dated July 17, 1990,  among  Registrant,  Koll  Woodside
                  Associates,  a  California  general  partnership,  and  Petula
                  Associates,   Ltd.,  an  Iowa  corporation.   Incorporated  by
                  reference to Exhibit 10.5 to the 1994 10-K.

10.6              Fourth  Amendment  dated May 20, 1994, to Lease dated July 17,
                  1990, among Registrant, Koll Woodside Associates, a California
                  general  partnership,  and Petula  Associates,  Ltd.,  an Iowa
                  corporation.  Incorporated by reference to Exhibit 10.1 to the
                  Registrant's  Quarterly  Report  on Form  10-Q for the  fiscal
                  quarterly period ended June 30, 1994 ("June 1994 10-Q").

10.7              Business Park Lease dated May 5, 1994, among Registrant,  Koll
                  Woodside  Associates,  a California general  partnership,  and
                  Petula Associates, Ltd., an Iowa corporation.  Incorporated by
                  reference to Exhibit 10.2 to the June 1994 10-Q.

10.8              Business  Park Lease  dated as of  December  16,  1994,  among
                  Registrant,  Petula Associates Ltd., an Iowa corporation,  and
                  Koll Portland  Associates,  a California general  partnership.
                  Incorporated by reference to Exhibit 10.1 to the  Registrant's
                  Quarterly  Report on Form 10-Q for the fiscal quarterly period
                  ended December 31, 1994.

10.9              Agreement  dated  December  9, 1987,  between  Registrant  and
                  Adolph Ferro,  Ph.D.  Incorporated by reference to Exhibit 4.3
                  to the 1988 S-1.*

10.10             Amendment to Agreement of December 9, 1987, dated November 11,
                  1996,   between   Registrant   and  Adolph  J.  Ferro,   Ph.D.
                  Incorporated by reference to Exhibit 10.13 to the Registrant's
                  Annual  Report on Form 10-K for the year ended  September  30,
                  1996.

10.11             Distribution  Agreement  dated as of April  1,  1994,  between
                  Registrant and Organon  Teknika  Corporation.  Incorporated by
                  reference to Exhibit 10.3 to the June 1994 10-Q.


                                     - 42 -
<PAGE>


10.12             Supply Agreement dated as of April 1, 1994, between Registrant
                  and Organon Teknika Corporation.  Incorporated by reference to
                  Exhibit 10.4 to the June 1994 10-Q.

10.13             Form of Indemnification  Agreement for directors and officers.
                  Incorporated by reference to Exhibit 10.4 to the  Registrant's
                  Registration Statement on Form S-4 (No. 333-15705).*

10.14             Amended and Restated  Employment  Agreement  dated  January 8,
                  1991 between Andrew S. Goldstein and Registrant.  Incorporated
                  by  reference  to  Exhibit  10.28 to the  Registrant's  Annual
                  Report on Form 10-K for the year ended September 30, 1991 (the
                  "1991 10-K").*

10.15             Amended and Restated  Employment  Agreement  dated  January 9,
                  1991,   between  Adolph  J.  Ferro,   Ph.D.,  and  Registrant.
                  Incorporated by reference to Exhibit 10.29 to the 1991 10-K.*

10.16             Amendment  to Amended and  Restated  Employment  Agreement  of
                  January 9, 1991, dated August 19, 1997, between Registrant and
                  Adolph J. Ferro, Ph.D.*

10.17             Employment  Agreement dated January 28, 1990,  between Gilbert
                  N. Miller and Registrant. Incorporated by reference to Exhibit
                  10.19 to the 1994 10-K.*

10.18             Employment  Agreement  dated  July 1,  1990,  between  John H.
                  Fitchen,  M.D. and  Registrant.  Incorporated  by reference to
                  Exhibit 10.20 to the 1994 10-K.*

10.19             Employment  Agreement  dated October 6, 1997,  between John W.
                  Morgan and Registrant.*

10.20             Option Agreement dated October 6, 1997, between John W. Morgan
                  and Registrant.*

10.21             Form of Employment  Agreement  between Charles E. Bergeron and
                  Registrant.*

10.22             Form of Employment  Agreement between J. Richard George, Ph.D.
                  and Registrant.*

10.23             Continuing  Guaranty  by  Epitope,  Inc.  of credit  agreement
                  between Andrew & Williamson  Sales Co. ("A&W") and Wells Fargo
                  Bank, N.A. ("Wells Fargo") and  Subordination  Agreement among
                  Registrant,  A&W and Wells Fargo each dated as of December 17,
                  1996.  Incorporated  by reference to Exhibit 10.2 to the March
                  1996 10-Q.

10.24             Amended  and  Restated  Employee  Benefits  Agreement  between
                  Epitope, Inc. and Agritope, Inc., dated December 19, 1997.*

10.25             Transition Services and Facilities  Agreement between Epitope,
                  Inc. and Agritope, Inc., dated December 1, 1997.

10.26             Tax Allocation  Agreement between Epitope,  Inc. and Agritope,
                  Inc., dated December 1, 1997.

21.               The Registrant's  subsidiaries  are Agritope,  Inc., an Oregon
                  corporation,   Vinifera,  Inc.,  an  Oregon  corporation,  and
                  Agrimax Floral Products,  Inc., a Minnesota  corporation.  The
                  Registrant also owns a 67 percent  interest in Superior Tomato
                  Associates,  L.L.C., a Delaware limited liability company, and
                  a 60  percent  interest  in  Epitope  KK, a  Japanese  limited
                  liability  company.  The  Registrant  will  no  longer  own an
                  interest in Agritope,  Inc.,  Vinifera,  Inc.,  Agrimax Floral
                  Products,   Inc.  or  Superior  Tomato   Associates,   L.L.C.,
                  following the spin-off of Agritope, Inc.

23.               Consent of Price Waterhouse LLP.

24.               Powers of Attorney.

27.               Financial Data Schedule.

*        Management contract or compensatory plan or arrangement


                                     - 43 -

                              SEPARATION AGREEMENT

                                     between

                                  Epitope, Inc.

                                       and

                                 Agritope, Inc.

                             Dated December 1, 1997










<PAGE>



                                TABLE OF CONTENTS

<TABLE>
                                                                                                              PAGE


                                    ARTICLE 1
<S>      <C>                                                                                                   <C>
                                   DEFINITIONS................................................................  1

                                    ARTICLE 2
                          PRE-DISTRIBUTION TRANSACTIONS.......................................................  4
         2.1      Private Placement of Agritope Equity.  .....................................................  4
         2.2      Agritope Corporate Actions..................................................................  5
         2.3      Epitope Approval............................................................................  5
         2.4      Related Agreements..........................................................................  5
         2.5      Securities Law Actions......................................................................  5

                                    ARTICLE 3
                                THE DISTRIBUTION..............................................................  6
         3.1      Discretion of Epitope Board; No Obligation..................................................  6
         3.2      Conditions to the Distribution..............................................................  6
         3.3      The Distribution............................................................................  6
         3.4      Fractional Shares...........................................................................  7

                                    ARTICLE 4
                    INDEMNIFICATION, CLAIMS AND OTHER MATTERS.................................................  7
         4.1      Indemnification by Epitope..................................................................  7
         4.2      Indemnification by Agritope.................................................................  7
         4.3      Insurance Proceeds..........................................................................  8
         4.4      Procedure for Indemnification...............................................................  8
         4.5      Other Claims................................................................................ 10
         4.6      Contribution in Respect of Certain Indemnifiable Losses..................................... 10
         4.7      No Beneficiaries............................................................................ 11

                                    ARTICLE 5
                           CERTAIN ADDITIONAL MATTERS......................................................... 11
         5.1      Construction of Agreements.................................................................. 11
         5.2      Consents and Assignments.................................................................... 11
         5.3      No Representations or Warranties............................................................ 11
         5.4      Officers and Directors...................................................................... 11
         5.5      Existing Intercompany Arrangements.......................................................... 12
         5.6      Termination of Intercompany Accounts........................................................ 12

                                    ARTICLE 6
                 ACCESS TO INFORMATION AND SERVICES; TECHNOLOGY............................................... 12
         6.1      Provision of Corporate Records.............................................................. 12



                                      - i -

<PAGE>



         6.2      Access to Information....................................................................... 12
         6.3      Production of Witnesses and Individuals..................................................... 12
         6.4      Retention of Records........................................................................ 13
         6.5      Confidentiality............................................................................. 13
         6.6      Privileged Matters.......................................................................... 14
         6.7      Technology.................................................................................. 15

                                    ARTICLE 7
                                    INSURANCE................................................................. 16
         7.1      Transition.................................................................................. 16
         7.2      Post-Distribution Date Claims............................................................... 16
         7.3      Allocation of Insurance Proceeds............................................................ 16

                                    ARTICLE 8
                               DISPUTE RESOLUTION............................................................. 17
         8.1      Negotiation and Binding Arbitration......................................................... 17
         8.2      Initiation.................................................................................. 17
         8.3      Submission to Arbitration................................................................... 17
         8.4      Equitable Relief............................................................................ 17

                                    ARTICLE 9
                                  MISCELLANEOUS............................................................... 18
         9.1      Entire Agreement............................................................................ 18
         9.2      Expenses.................................................................................... 18
         9.3      Governing Law............................................................................... 18
         9.4      Jurisdiction and Venue...................................................................... 18
         9.5      Notices..................................................................................... 18
         9.6      Modification of Agreement................................................................... 19
         9.7      Termination................................................................................. 19
         9.8      Successors and Assigns...................................................................... 19
         9.9      No Third Party Beneficiaries................................................................ 19
         9.10     Titles and Headings; Interpretation......................................................... 19
         9.11     Exhibits.................................................................................... 20
         9.12     Severability................................................................................ 20
         9.13     No Waiver................................................................................... 20
         9.14     Survival.................................................................................... 20
         9.15     Counterparts................................................................................ 20
</TABLE>




                                     - ii -

<PAGE>



                              SEPARATION AGREEMENT


                  THIS SEPARATION  AGREEMENT (this  "Agreement") is entered into
by and between Epitope, Inc., an Oregon corporation  ("Epitope"),  and Agritope,
Inc., a Delaware corporation ("Agritope"), as of December 1, 1997.

                                    RECITALS

          A.  Agritope is a wholly  owned  subsidiary  of  Epitope,  principally
engaged in research and development of agricultural products using plant genetic
engineering.

          B. The board of directors of Epitope has determined  that it is in the
best interests of the shareholders of Epitope to separate  Agritope from Epitope
by  distributing  as a dividend to holders of Epitope common stock, no par value
("Epitope  Stock"),  all of the issued and outstanding shares of Agritope common
stock,  par value $.01 per share,  including  certain  preferred  stock purchase
rights  attached   thereto  (the  "Agritope   Stock"),   held  by  Epitope  (the
"Distribution"), as provided herein; and

          C.  Epitope and Agritope  have  determined  that it is  necessary  and
desirable to establish the principal corporate  transactions  required to effect
the  separation  of  Agritope  from  Epitope,  and to enter into  certain  other
agreements  governing  matters relating to the Distribution and the relationship
between Epitope and Agritope after the Distribution.

                  NOW,  THEREFORE,  in  consideration  of the  foregoing and the
mutual covenants and agreements contained herein,  Epitope and Agritope agree as
follows:

                                    ARTICLE 1
                                   DEFINITIONS

                  Capitalized  terms  shall  have the  meanings  given  below or
elsewhere in this Agreement.

                  Action:  any  action,  claim,  suit,   arbitration,   inquiry,
subpoena,  discovery request, proceeding or investigation by or before any court
or grand jury, any governmental or other regulatory or administrative  agency or
commission or any arbitration tribunal.

                  Affiliate:  with  respect to any  specified  person,  a person
that, directly or indirectly,  through one or more intermediaries,  controls, or
is  controlled  by,  or is under  common  control  with such  specified  person;
provided,  however, that unless otherwise expressly provided, the Agritope Units
and Epitope  shall not be deemed to be Affiliates of one another for purposes of
this Agreement.


                                      - 1 -
<PAGE>


                  Agent:   ChaseMellon   Shareholder   Services,   L.L.C.,   the
distribution  agent appointed by Epitope and Agritope to distribute the Agritope
Stock in connection with the Distribution.

                  Agritope   Business:   (i)  the   business  of  research   and
development, marketing and sales of novel agricultural products using both plant
genetic  engineering and other modern  methods;  (ii) the businesses of Vinifera
involving  grapevine  plant  propagation  and disease  screening and elimination
programs;  and (iii) any other  business or  operation  conducted by an Agritope
Unit at any time. The Agritope Business does not include the business  conducted
by Andrew and Williamson Sales, Co., a California  corporation formerly owned by
Epitope.

                  Agritope  Employee:  any employee of a Core  Company,  and any
employee  of  Epitope  who is  assigned  to a Core  Company  on or  prior to the
Distribution Date.

                  Agritope  Preferred:  Agritope Series A preferred  stock,  par
value $.01 per share.

                  Agritope Unit:  each Core Company and Related Company.

                  Books and  Records:  books and records  (or true and  complete
copies  thereof),   including  computerized  records,  of  Epitope  that  relate
principally  to any Agritope Unit or the Agritope  Business or decisions made by
Epitope that relate to Agritope,  including,  without limitation,  all books and
records relating to Agritope Employees, the purchase of materials,  supplies and
services by any Agritope Unit,  and the  technologies,  customers,  and business
partners of any Agritope Unit;  and all files  relating to any Action  involving
any Agritope Unit or involving any Agritope Employee or director  (including any
Action that arose when the Agritope Employee was employed by Epitope).

                  Code: the Internal Revenue Code of 1986, as amended.

                  Commission: the Securities and Exchange Commission.

                  Core Company: each of Agritope,  Vinifera,  and Agrimax Floral
Products, Inc., a Minnesota corporation.

                  Distribution Date: the effective date of the Distribution,  as
determined by the Epitope Board.

                  Distribution Prospectus: the information  statement/prospectus
to  be  distributed  to  holders  of  Epitope  Stock  in  connection   with  the
Distribution.


                                      - 2 -
<PAGE>


                  Employee Benefits Agreement:  the agreement,  substantially in
the form of  Exhibit A hereto,  pursuant  to which  Epitope  and  Agritope  will
provide for certain employee benefit matters.

                  Epitope Board:  the board of directors of Epitope.

                  Form  S-1:  the  Registration  Statement  on Form S-1 filed by
Agritope with the Commission to register the Agritope Stock to be distributed to
holders of Epitope Stock in the Distribution.

                  Indemnifiable   Losses:  with  respect  to  any  claim  by  an
Indemnitee for indemnification  authorized pursuant to Article 4 hereof, any and
all losses,  liabilities,  claims,  damages,  obligations,  payments,  costs and
expenses (including,  without limitation,  the costs and expenses of any and all
Actions, demands, assessments,  judgments,  settlements and compromises relating
thereto and  reasonable  attorney  fees and  expenses in  connection  therewith,
including attorney fees before and at trial and in connection with any appeal or
petition  for review)  suffered by such  Indemnitee  with respect to such claim,
other than those arising out of an individual's service as a director,  officer,
or  employee  of the entity  that would be the  Indemnifying  Party but for this
exclusion.

                  Indemnifying Party: any party who is required to pay any other
person pursuant to Article 4 hereof.

                  Indemnitee:  any party who is entitled to receive payment from
an Indemnifying Party pursuant to Article 4 hereof.

                  Indemnity  Payment:   the  amount  an  Indemnifying  Party  is
required to pay an Indemnitee pursuant to Article 4 hereof.

                  Insurance  Proceeds:  those  monies (i) received by an insured
from an insurance  carrier or (ii) paid by an insurance carrier on behalf of the
insured,   in   either   case  net  of  any   applicable   premium   adjustment,
retrospectively rated premium,  deductible,  retention,  cost or reserve paid or
held by or for the benefit of such insured.

                  Insured Claims: those Liabilities that, individually or in the
aggregate,  are covered  within the terms and conditions of any of the Policies,
whether  or  not  subject  to  deductibles,  co-insurance,  uncollectibility  or
retrospectively-rated  premium  adjustments,  but only to the  extent  that such
Liabilities are within applicable Policy limits, including aggregates.

                  Liabilities:  any and all debts,  liabilities and obligations,
whether accrued,  contingent or reflected on a balance sheet,  known or unknown,
including,  without limitation,  those arising under any law, rule,  regulation,
Action, order or consent decree of any


                                      - 3 -
<PAGE>


governmental  entity  or any  judgment  of any court of any kind or award of any
arbitrator of any kind,  and those  arising  under any  contract,  commitment or
undertaking.

                  Policies:  insurance  policies and insurance  contracts of any
kind, including, without limitation, primary and excess policies,  comprehensive
general  liability  policies,  automobile  and workers'  compensation  insurance
policies, and self-insurance arrangements, together with the rights and benefits
thereunder.

                  Private  Placement:  the sale of  Agritope  Stock or  Agritope
Preferred to certain  private  investors in  transactions  intended to be exempt
from  registration  under  the  Securities  Act  pursuant  to  Regulation  D  or
Regulation S under the Securities Act.

                  Record Date:  the date  determined by the Epitope Board as the
record date for the Distribution.

                  Related   Agreements:   the   Employee   Benefits   Agreement,
Transition Services and Facilities Agreement,  Tax Allocation Agreement, and all
other agreements entered into by Epitope and Agritope pursuant to this Agreement
or otherwise in connection with the Distribution.

                  Related Company: each of UAF, Limited Partnership,  a Delaware
limited  partnership,  Petals USA, Inc., a Minnesota  corporation,  and Superior
Tomato Associates, L.L.C., a Delaware limited liability company.

                  Securities Act: the Securities Act of 1933, as amended.

                  Shared  Policies:  all Policies  owned or  maintained by or on
behalf of Epitope prior to the  Distribution  Date,  relating to both  Epitope's
business and the Agritope Business.

                  Tax Allocation Agreement: the agreement,  substantially in the
form of Exhibit B hereto,  pursuant to which  Epitope and Agritope  will provide
for certain tax matters.

                  Transition Services and Facilities  Agreement:  the agreement,
substantially  in the form of Exhibit C hereto,  pursuant to which  Epitope will
provide certain  transitional  services and facilities to Agritope following the
Distribution Date.

                  Vinifera:  Vinifera, Inc., an Oregon corporation.

                                    ARTICLE 2
                          PRE-DISTRIBUTION TRANSACTIONS

                  2.1 Private  Placement of Agritope Equity.  Agritope shall use
its best efforts to obtain  commitments  in the form of executed  share purchase
agreements from investors


                                      - 4 -
<PAGE>


interested in investing in Agritope in a Private  Placement to occur immediately
following the Distribution. Agritope shall use its best efforts to determine the
aggregate amount of committed investment capital as soon as practicable.

         2.2  Agritope  Corporate  Actions.  Prior  to  the  Distribution  Date,
Agritope will take all corporate action necessary to effect the Distribution and
comply with this Agreement and any Related Agreements, including but not limited
to  authorizing a  recapitalization  such that a sufficient  number of shares of
Agritope  Stock  are  available  to  effect  the  Distribution,   and  approving
appropriate   stock-based   compensation   or  other   plans,   agreements   and
arrangements, as provided for in the Employee Benefits Agreement.

         2.3 Epitope  Approval.  Subject to the business judgment of the Epitope
Board,  Epitope shall  cooperate with Agritope in effecting any actions that are
reasonably necessary or desirable to be taken by Agritope in connection with the
transactions contemplated by this Agreement or any Related Agreements including,
without limitation,  approving or ratifying as sole stockholder of Agritope, the
election  or  appointment  of  directors  of  Agritope  to serve  following  the
Distribution,  appropriate stock-based  compensation or other plans for Agritope
Employees, board members and consultants,  and any recapitalization necessary to
effect the Distribution.

         2.4  Related  Agreements.  Epitope  and  Agritope  will use their  best
efforts to cause,  on or before the Record Date,  the  execution and delivery by
each party of the Related  Agreements and any other agreements  deemed necessary
or  desirable  by the  parties to  establish  and  govern the  post-Distribution
relationship of the parties.

         2.5      Securities Law Actions.

                  (a)  Epitope  and  Agritope  will  prepare,  and file with the
         Commission,  the  Form  S-1,  including  the  Distribution  Prospectus.
         Epitope and Agritope shall use reasonable efforts to cause the Form S-1
         to  become  effective  under  the  Securities  Act,  and,  as  soon  as
         practicable  after  the  Distribution  Date,  Epitope  shall  mail  the
         Distribution  Prospectus  to holders of Epitope  Stock as of the Record
         Date. The joint  obligations of Epitope and Agritope under this Section
         2.4(a) shall not affect their respective obligations of indemnity under
         Article 4 hereof.

                  (b) Epitope and Agritope shall take all such actions as may be
         necessary or  appropriate  under the securities or blue sky laws of the
         various states or other political subdivisions of the United States and
         other  countries in connection  with the  Distribution  and the Private
         Placement.

                  (c)  Agritope  will  prepare  and file,  and will use its best
         efforts to have  approved,  an  application  for  inclusion of Agritope
         Stock on The Nasdaq SmallCap Market.


                                      - 5 -
<PAGE>


                                    ARTICLE 3
                                THE DISTRIBUTION

         3.1 Discretion of Epitope Board; No Obligation.  The Epitope Board will
have the sole  discretion to determine,  by resolution,  the Record Date and all
appropriate procedures in connection with the Distribution. Nothing contained in
this  section  shall be  interpreted  to create  any  obligation  on the part of
Epitope or  Agritope to effect or to seek to effect the  Distribution  or in any
way limit Epitope's right to terminate this Agreement prior to the Record Date.

         3.2 Conditions to the  Distribution.  The  Distribution  will not occur
prior to such time as each of the following  conditions  have been  satisfied or
have been waived by the Epitope Board, in its sole discretion:

                  (a)  Agritope  shall have  received  binding  commitments  for
         financing in an amount the Epitope  Board deems  sufficient  to support
         the  operations  of the Core  Companies  as  businesses  separate  from
         Epitope for a period of not less than two years;

                  (b) any  waivers,  consents,  or  amendments  with  respect to
         agreements or other obligations entered into by or binding upon Epitope
         or any Core Company shall have been executed and received to the extent
         necessary to prevent  Epitope or the Core Company from being in default
         with  respect  to  such   agreements  or   obligations   following  the
         Distribution;

                  (c) an opinion  shall have been  received  from Miller,  Nash,
         Wiener,  Hager & Carlsen LLP in form and substance  satisfactory to the
         Epitope  Board,  with  respect to the federal  income tax status of the
         Distribution under Section 355 of the Code;

                  (d) the Form S-1 shall  have been  declared  effective  by the
         Commission;

                  (e)  any  material   approvals   and  consents   necessary  to
         consummate  the  Distribution  shall have been obtained and shall be in
         full force and  effect,  and no Action  shall be pending or  threatened
         with respect to the Distribution; and

                  (f) no other event or development shall have occurred that, in
         the judgment of the Epitope Board, would have a material adverse effect
         on Epitope or its shareholders.

                  3.3 The Distribution.  On or prior to the Record Date, Epitope
will deliver its  certificate or  certificates  for Agritope Stock to the Agent.
Epitope  will  deliver  to  the  Agent  a  stock   certificate  or  certificates
representing,  in the  aggregate  (and rounded down to the nearest whole share),
the  number  of shares  necessary  so that one  share of  Agritope  Stock may be
distributed to Epitope  shareholders  of record for every five shares of Epitope
Stock


                                      - 6 -
<PAGE>


outstanding on the Record Date. Thereafter,  Epitope shall instruct the Agent to
distribute to holders of record of Epitope  Stock on the Record Date,  one share
of Agritope Stock for every five shares of Epitope  Stock.  All of the shares of
Agritope Stock issued in the Distribution will be fully paid,  nonassessable and
free of preemptive  rights. If the aggregate number of shares held by Epitope or
delivered  to  the  Agent  as of  the  Record  Date  exceeds  the  number  to be
distributed to Epitope shareholders,  Epitope shall return or instruct the Agent
to return the excess  shares to  Agritope  for  cancellation,  as an  additional
contribution to capital.

                  3.4 Fractional  Shares. No certificates or scrip  representing
fractional   shares  of  Agritope  Stock  will  be  issued  as  a  part  of  the
Distribution, and in lieu of receiving fractional shares, each holder of Epitope
Stock who would otherwise be entitled to receive a fractional  share of Agritope
Stock  pursuant to the  Distribution  will  receive  cash from  Epitope for such
fractional share.

                                    ARTICLE 4
                    INDEMNIFICATION, CLAIMS AND OTHER MATTERS

                  4.1 Indemnification by Epitope. Epitope will indemnify, defend
and hold  harmless the  Agritope  Units and each of their  directors,  officers,
employees,  and agents from and against any and all  Indemnifiable  Losses after
the  Distribution  Date arising out of or due to,  directly or  indirectly:  (i)
Liabilities  incurred  in the course of the  business or  operations  of Epitope
exclusive of the Agritope Business; (ii) any claim that the information included
in the Distribution  Prospectus or the Form S-1 under (A) the captions  "Summary
- --  Distributing  Corporation  and  Business,"  "-- Financing of Agritope,"  "--
Distribution  Ratio," "-- Record Date," "-- Distribution  Date," "--Shares to be
Distributed,"  "--  Fractional  Share  Interests,"  "-- Primary  Purposes of the
Distribution," "-- Tax Consequences," or "--Relationship  with Epitope after the
Distribution,"  and the  corresponding  information  appearing  elsewhere in the
Distribution  Prospectus,  (B) the captions "The Distribution -- Reasons for the
Distribution," "-- Manner of Effecting the Distribution" and "-- Certain Federal
Income Tax  Consequences,"  or (C) the information  concerning Vector Securities
International,  Inc. is false or misleading with respect to any material fact or
omits to state any material fact  required to be stated  therein or necessary in
order to make the statements  therein, in light of the circumstances under which
they were  made,  not  misleading;  (iii) any third  party  claim of  failure by
Epitope to perform  under,  or of any  violation by Epitope of, any provision of
this  Agreement or any Related  Agreement,  which is to be performed or complied
with by Epitope; and (iv) breaches of this Agreement or any Related Agreement by
Epitope.

                  4.2  Indemnification  by Agritope.  Agritope  will  indemnify,
defend and hold harmless Epitope and each of its directors, officers, employees,
and  agents  from  and  against  any  and all  Indemnifiable  Losses  after  the
Distribution  Date  arising  out of or  due  to,  directly  or  indirectly:  (i)
Liabilities  incurred  in  the  course  of  the  Agritope  Business,   including
obligations  under any  existing  guaranty  by  Epitope  of  obligations  of any
Agritope Unit; (ii) any claim that any  information  provided in connection with
the Private Placement,  other than the information listed in Section 4.1(ii), is
false or misleading with respect to any material


                                      - 7 -
<PAGE>


fact or omits to state  any  material  fact  required  to be stated  therein  or
necessary in order to make the statements therein, in light of the circumstances
under  which they were  made,  not  misleading,  or that the  Private  Placement
otherwise  violated the applicable law of any country;  (iii) any claim that the
information included in the Distribution  Prospectus or Form S-1, other than the
information  listed in  Section  4.1(ii)  hereof,  is false or  misleading  with
respect to any material  fact or omits to state any material fact required to be
stated therein or necessary in order to make the statements therein, in light of
the circumstances under which they were made, not misleading;  (iv) any claim by
any person or entity,  other than Epitope or Agritope,  that is a shareholder or
equity owner of an Agritope Unit, relating to such person's or entity's stock or
other equity interest in an Agritope Unit; (v) any third party claims of failure
by an Agritope Unit to perform  under,  or any violation by an Agritope Unit of,
any  provision  of  this  Agreement  or any  Related  Agreement  which  is to be
performed  or  complied  with by an  Agritope  Unit;  and (vi)  breaches of this
Agreement or any Related Agreement by an Agritope Unit.

                  4.3 Insurance Proceeds. The amount that any Indemnifying Party
is or may be  required  to pay to any  Indemnitee  pursuant  to  Section  4.1 or
Section   4.2  hereof   will  be   reduced   (including,   without   limitation,
retroactively) by any Insurance Proceeds and other amounts actually recovered by
or on behalf of such Indemnitee in reduction of the related  Indemnifiable Loss.
If an  Indemnitee  shall have  received  an  Indemnity  Payment in respect of an
Indemnifiable Loss and shall subsequently actually receive Insurance Proceeds or
other amounts in respect of such  Indemnifiable  Loss as specified  above,  then
such Indemnitee will pay to such Indemnifying Party a sum equal to the amount of
such Insurance Proceeds or other amounts actually received.  Notwithstanding the
foregoing,  nothing  in this  section  grants  to an  Indemnitee  any  direct or
indirect rights or benefits to insurance coverage,  nor requires an Indemnifying
Party to make any claim for insurance coverage.

                  4.4      Procedure for Indemnification.

                  (a) If  either  party  shall  receive  notice  of any claim or
         Action brought, asserted,  commenced or pursued by any person or entity
         not a party to this Agreement (hereinafter a "Third Party Claim"), with
         respect  to which the  other  party is or may be  obligated  to make an
         Indemnity Payment, it shall give such other party prompt notice thereof
         (including  any  pleadings  relating   thereto),   specifying  in  such
         reasonable  detail  as is known to it the  nature of such  Third  Party
         Claim and the amount or estimated  amount thereof;  provided,  however,
         that the failure of a party to give notice as provided in this  Section
         4.4  shall  not  relieve   the  other  party  of  its   indemnification
         obligations  under this Article 4, except to the extent that such other
         party is actually prejudiced by such failure to give notice.

                  (b) For any  Third  Party  Claim  concerning  which  notice is
         required to be given, and, in fact, is given under  subparagraph (a) of
         this  Section  4.4,  the  Indemnifying  Party shall  defend in a timely
         manner,  to the extent permitted by law, such Third Party Claim through
         counsel appointed by the Indemnifying  Party and reasonably  acceptable
         to the Indemnitee. Once an Indemnifying Party has commenced


                                      - 8 -
<PAGE>


         its defense of an  Indemnitee,  it cannot  withdraw  from such  defense
         until conclusion of the matter,  unless the Indemnified Party agrees to
         the  withdrawal  or the  Indemnitee is also  defending  the claim.  The
         Indemnitee  shall have the right to  participate  in the defense of the
         Third Party Claim by employing separate counsel at its own expense.

                  (c) If a party  responds to a notice of a Third Party Claim by
         denying  its  obligation  to  indemnify  the  other  party,  or if  the
         Indemnifying   Party  fails  to  defend  in  a  timely  or   reasonably
         satisfactory  manner,  the Indemnitee  shall be entitled to defend such
         Third Party Claim through counsel  appointed by it. In addition,  if it
         is later  determined that such party  wrongfully  denied such claim, or
         the  Indemnifying  Party  failed  to defend  timely or in a  reasonably
         satisfactory  manner,  then the Indemnifying  Party shall (i) reimburse
         the  Indemnitee  for  all  reasonable  costs  and  expenses  (including
         attorney fees before and at trial and in connection  with any appeal or
         petition for review,  but excluding salaries of officers and employees)
         incurred by the Indemnitee in connection with its defense of such Third
         Party Claim; and (ii) be estopped from  challenging a judgment,  order,
         settlement,  compromise,  or consent judgment resolving the Third Party
         Claim entered into in good faith by the  Indemnitee  (if such claim has
         been resolved  prior to the  conclusion of the  proceeding  between the
         Indemnitee  and  Indemnifying  Party).  An  Indemnifying  Party,  after
         initially rejecting a claim for defense or indemnification,  may defend
         and indemnify the  Indemnitee,  at any time prior to the  resolution of
         said  Third  Party  Claim,  for  such  claim,  provided  that  (x)  the
         Indemnifying  Party  reimburses the Indemnitee for all reasonable costs
         and  expenses  (including  attorney  fees  before  and at trial  and in
         connection  with any  appeal or  petition  for  review,  but  excluding
         salaries of officers  and  employees)  incurred  by the  Indemnitee  in
         connection  with its  defense of such Third  Party Claim up to the time
         the  Indemnifying  Party  assumes  control of the defense of such claim
         (including  costs  incurred in the  transition  of the defense from the
         Indemnitee to the  Indemnifying  Party);  and (y) the assumption of the
         defense of the Third Party Claim is not  expected to prejudice or cause
         harm to the Indemnitee.

                  (d)  With   respect  to  any  Third   Party  Claim  for  which
         indemnification  has been claimed hereunder,  no party shall enter into
         any compromise or  settlement,  or consent to the entry of any judgment
         which (i) does not  include as a term  thereof  the giving by the third
         party  of a  release  to the  Indemnitee  from  all  further  liability
         concerning such Third Party Claim on terms no less favorable than those
         obtained by the party  entering  into such  compromise,  settlement  or
         consent;  or (ii) imposes any obligation on the Indemnitee without such
         Indemnitee's   written   consent  (such  consent  not  to  be  withheld
         unreasonably), except an obligation to pay money which the Indemnifying
         Party  has  agreed to pay and has the  ability  to pay on behalf of the
         Indemnitee.  In the  event  that an  Indemnitee  enters  into  any such
         compromise,  settlement or consent  without the written  consent of the
         Indemnifying  Party  (other  than as  contemplated  by  Section  4.4(c)
         hereof),  the entry of such  compromise,  settlement  or consent  shall
         relieve  the  Indemnifying  Party  of  its  indemnification  obligation
         related  to  the  claims  underlying  such  compromise,  settlement  or
         consent.


                                      - 9 -
<PAGE>


                  (e)  Upon  final   judgment,   determination,   settlement  or
         compromise of any Third Party Claim, and unless otherwise agreed by the
         parties in writing, the Indemnifying Party shall pay promptly on behalf
         of the Indemnitee,  or to the Indemnitee in reimbursement of any amount
         theretofore  required  to be  paid by the  Indemnitee,  the  amount  so
         determined by final judgment, determination,  settlement or compromise.
         Upon the payment in full by the Indemnifying  Party of such amount, the
         Indemnifying  Party shall  succeed to the rights of such  Indemnitee to
         the extent not waived in  settlement,  against the third party who made
         such Third Party Claim and any other person who may have been liable to
         the Indemnitee with respect to the indemnified matter.

                  (f) In connection  with defending  against Third Party Claims,
         the  parties  shall  cooperate  with and  assist  each  other by making
         available all employees,  books,  records,  communications,  documents,
         items and matters  within their  knowledge,  possession or control that
         are necessary,  appropriate or reasonably  deemed relevant with respect
         to defense of such  claims;  provided,  however,  that  nothing in this
         subparagraph  (f)  shall  be  deemed  to  require  the  waiver  of  any
         privilege,  including  the  attorney-client  privilege,  or  protection
         afforded by the attorney work product doctrine. In addition, regardless
         of the party actually  defending a Third Party Claim for which there is
         an indemnity  obligation  under Section 4.1 or 4.2 hereof,  the parties
         shall give each other regular  status  reports  relating to such action
         with detail  sufficient to permit the other party to assert and protect
         its rights and obligations under this Agreement.

                  4.5 Other Claims.  Any claim for an  Indemnifiable  Loss which
does not result from a Third  Party  Claim  shall be asserted by written  notice
from the Indemnitee to the Indemnifying  Party within 120 days of first learning
thereof.  All such claims that are not timely asserted  pursuant to this section
shall be deemed to be forever  waived.  The  Indemnitee's  written  notice shall
contain such  information as the  Indemnitee  has regarding the alleged  breach.
Such  Indemnifying  Party shall have a period of 120 days (or such  shorter time
period as may be required by law as indicated by the  Indemnitee  in the written
notice) within which to respond  thereto.  If such  Indemnifying  Party does not
respond within such 120-day period (or lesser period),  such Indemnifying  Party
shall be deemed to have accepted  responsibility  to make payment for the amount
of Indemnifiable Loss and shall have no further right to contest the validity of
such claim.  If such  Indemnifying  Party does  respond  within such 120-day (or
lesser) period and rejects such claim in whole or in part, such Indemnitee shall
be free to pursue such  remedies as may be  available  under  applicable  law or
under this Agreement.

                  4.6 Contribution in Respect of Certain  Indemnifiable  Losses.
If the  indemnification  provided  for in this  Article 4 is  unavailable  to an
Indemnitee in respect of any  Indemnifiable  Loss arising out of, or related to,
information contained in the Distribution  Prospectus or the related Form S-1 or
used in connection with the Private Placement,  the Indemnifying  Party, in lieu
of indemnifying such Indemnitee,  shall contribute to the amount paid or payable
by such Indemnitee as a result of such Indemnifiable Loss, in such proportion as
is  appropriate  to reflect  the  relative  fault of  Agritope,  its  directors,
officers,


                                     - 10 -
<PAGE>


employees or agents,  on the one hand,  and Epitope,  its  directors,  officers,
employees or agents,  on the other hand,  in connection  with the  statements or
omissions which resulted in such Indemnifiable  Loss. The relative fault of such
respective  groups  shall be  determined  by reference  to, among other  things,
whether  the  untrue or  alleged  untrue  statement  of a  material  fact or the
omission or alleged  omission to state a material  fact  relates to  information
supplied by either such group.

                  4.7 No Beneficiaries.  Except to the extent expressly provided
otherwise in this Article 4, the indemnification  provided for by this Article 4
shall  not inure to the  benefit  of any third  party or  parties  and shall not
relieve any insurer who would  otherwise  be  obligated  to pay any claim of the
responsibility  with respect thereto or, solely by virtue of the indemnification
provisions hereof,  provide any such subrogation rights with respect thereto and
each party agrees to waive such rights  against the other to the fullest  extent
permitted.

                                    ARTICLE 5
                           CERTAIN ADDITIONAL MATTERS

                  5.1  Construction  of  Agreements.  Notwithstanding  any other
provisions  in this  Agreement to the  contrary,  in the event and to the extent
that  there is a conflict  between  the  provisions  of this  Agreement  and the
provisions of any Related  Agreement,  the provisions of such Related  Agreement
shall control.

                  5.2 Consents and  Assignments.  Epitope and Agritope shall use
reasonable efforts to obtain,  either before or after the Distribution Date, any
consent,  approval or amendment  required to novate and/or assign to an Agritope
Unit or to Epitope, as appropriate,  all agreements,  leases, licenses and other
rights of any nature whatsoever relating solely to that party's business.

                  5.3 No Representations or Warranties. Agritope understands and
agrees that Epitope is not, in this  Agreement,  or in any Related  Agreement or
any other agreement or document contemplated by this Agreement,  representing or
warranting in any way as to the businesses and Liabilities retained, transferred
or assumed in  connection  with the  Distribution,  or that the obtaining of the
consents or approvals, the execution and delivery of any ancillary or amendatory
agreements or the making of the filings and  applications  contemplated  by this
Agreement  will  satisfy the  provisions  of all  applicable  agreements  or the
requirements of all applicable laws or judgments, it being understood and agreed
that, subject to Section 5.2 hereof,  Agritope shall bear the economic and legal
risk of the business and Liabilities  retained or assumed hereunder by Agritope,
and the legal and economic risk that any necessary consents or approvals are not
obtained or that any  requirements  of law or judgments are not complied with or
satisfied.

                  5.4 Officers and  Directors.  Agritope and Epitope  shall take
all  necessary  actions to elect or otherwise  appoint,  as of the  Distribution
Date,  individuals  to be directors  or officers  (or both) of Agritope,  as set
forth in the Form S-1, and to cause the resignation of


                                     - 11 -
<PAGE>


individuals  as officers and directors of each so that there are only two common
directors  of  Agritope  and Epitope as of the  Distribution  Date and no common
officers.

                  5.5 Existing  Intercompany  Arrangements.  Except as otherwise
provided in this Agreement, any and all agreements, arrangements, commitments or
understandings,  whether or not in writing, between Epitope and Agritope will be
terminated  and of no  further  force and  effect as of the  Distribution  Date.
Following  the  Distribution  Date,  the parties shall discuss in good faith the
provision of any  services  and products to be provided by the other,  but which
inadvertently  were not the  subject  of this  Agreement  or any  other  Related
Agreement.

                  5.6 Termination of Intercompany Accounts.  Except as described
in Section 9.2, any intercompany receivable, payable or loan between Epitope and
Agritope  outstanding on the  Distribution  Date will be deemed  terminated as a
result of the  consummation of the  transactions  contemplated in this Agreement
and will be treated as a capital contribution.

                                    ARTICLE 6
                 ACCESS TO INFORMATION AND SERVICES; TECHNOLOGY


                  6.1 Provision of Corporate Records. Following the Distribution
Date, all Books and Records will remain the property of Epitope but will be made
available upon  reasonable  notice and during normal  business hours to Agritope
for review and  duplication  until the earlier of (i) notice from  Agritope that
such Books and Records  are no longer  needed by  Agritope,  or (ii) the seventh
anniversary of the Distribution Date.

                  6.2  Access to  Information.  From and after the  Distribution
Date,  Epitope  and  Agritope  will  afford to each  other  and to each  other's
authorized  accountants,  legal  counsel  and other  designated  representatives
reasonable access and duplicating  rights (with copying costs to be borne by the
requesting  party)  during  normal  business  hours to all Books and Records and
documents,   communications,   items  and  matters,   including   computer  data
(collectively,  "Information")  within each  other's  knowledge,  possession  or
control,  relating to the Agritope Units or Agritope Employees,  insofar as such
access is reasonably  required by Epitope or Agritope (and shall use  reasonable
efforts  to  cause  persons  or firms  possessing  Information  to give  similar
access).  Information  may be requested  under this Article 6 for any legitimate
business purpose  including,  without  limitation,  audit,  accounting,  claims,
Actions,  litigation  and tax  purposes,  as well as for purposes of  fulfilling
disclosure and reporting obligations, but not for competitive purposes.

                  6.3  Production of Witnesses and  Individuals.  From and after
the Distribution  Date, Epitope and Agritope will use reasonable efforts to make
available  to each other,  upon  written  request,  their  respective  officers,
directors,  employees and agents for fact finding,  consultation  and interviews
and as witnesses to the extent that any such person may  reasonably  be required
in connection with any Actions in which the requesting party may


                                     - 12 -
<PAGE>


from time to time be  involved.  Epitope and Agritope  agree to  reimburse  each
other for  reasonable  out-of-pocket  expenses  (but not labor charges or salary
payments)  incurred by the other in connection  with providing  individuals  and
witnesses pursuant to this Section 6.3.

                  6.4  Retention  of  Records.  Except  when a longer  retention
period  is  otherwise  required  by law or  agreed to in  writing,  Epitope  and
Agritope will retain,  for seven years  following  the  Distribution  Date,  all
material  Information  relating to Agritope.  Notwithstanding the foregoing,  in
lieu of  retaining  any specific  Information,  Epitope or Agritope may offer in
writing  to deliver  such  Information  to the other  and,  if such offer is not
accepted  within 90 days, the offered  Information may be destroyed or otherwise
disposed of at any time.  If a recipient of such offer  requests in writing that
any of the  Information  proposed to be destroyed or disposed of be delivered to
such  requesting  party,  the party  proposing the  destruction or disposal will
promptly  arrange for the delivery of the requested  Information (at the cost of
the requesting party).

                  6.5 Confidentiality.  During the period that Agritope has been
a wholly  owned  subsidiary  of Epitope,  employees of both Epitope and Agritope
have become  aware of a wide  variety of  otherwise  confidential  business  and
technical  information  of the other party.  Such  information of Epitope or the
Agritope  Units (the  "Disclosing  Party") shall be protected by the other party
(the "Recipient") as follows:

                  (a)  "Confidential  Information"  means nonpublic  information
         concerning the Disclosing Party's business,  business plans,  products,
         or technology, whether disclosed before or after the Distribution Date,
         including but not limited to strategic and long-range plans,  financial
         and operating results, identities of principal customers and suppliers,
         plans for capital  expenditures,  plans for expansion into new markets,
         research projects and results, and trade secrets.

                  (b) "Confidential  Information" for purposes of this agreement
excludes:

                           (i)   information   which  is  or  becomes   publicly
                  available through no act of the Recipient,  from and after the
                  date of public availability;

                           (ii)  information  disclosed  to the  Recipient  by a
                  third  party,   provided:   (A)  under  the  circumstances  of
                  disclosure   the   Recipient   does   not   have  a  duty   of
                  non-disclosure owed to such third party; (B) the third party's
                  disclosure does not violate a duty of  non-disclosure  owed to
                  another,   including  the  Disclosing   Party;   and  (C)  the
                  disclosure by the third party is not otherwise unlawful; and

                           (iii)   information   developed   by  the   Recipient
                  independent of any confidential  information of the Disclosing
                  Party which is known by the Recipient on the Distribution Date
                  and/or disclosed by the Disclosing Party thereafter.


                                     - 13 -
<PAGE>


                  (c) The  Recipient  will hold,  and will  cause its  officers,
         employees,  agents,  consultants,  advisors and  Affiliates to hold, in
         strict confidence, and not to disclose, unless compelled to disclose by
         judicial  or   administrative   process  or,  in  the  opinion  of  its
         independent   legal  counsel,   by  other   requirements  of  law,  all
         Confidential Information of the Disclosing Party.

                  (d) The Recipient  shall protect  Confidential  Information of
         the Disclosing Party by using the same degree of care, but no less than
         a reasonable degree of care, to prevent unauthorized  disclosure as the
         Recipient  uses to protect its own  confidential  information of a like
         nature.

                  (e) The Recipient may disclose Confidential Information of the
         Disclosing Party to its employees, Affiliates, sublicensees, agents and
         advisors (such as attorneys,  accountants  and other  consultants)  who
         need to know the information and are obligated by policy,  agreement or
         otherwise to avoid  unauthorized  use and  disclosure  of  Confidential
         Information.

                  (f) The  foregoing  restrictions  shall expire ten years after
         the later of the  Distribution  Date or the date of disclosure,  unless
         and to the extent Epitope and Agritope agree to a longer period for the
         foregoing   restrictions   with  respect  to  specific   categories  of
         Confidential Information.

                  6.6      Privileged Matters.

                  (a) Epitope and  Agritope  will each  maintain,  preserve  and
         assert all privileges,  including, without limitation, any privilege or
         protection   arising   under  or   relating   to  any   attorney-client
         relationship  (including,  without limitation,  the attorney-client and
         work product  privileges),  that existed prior to the Distribution Date
         in favor of the other  party  ("Privilege"  or  "Privileges").  Neither
         party will waive any Privilege that could be asserted under  applicable
         law by the other  party  (the  "Privileged  Party")  without  the prior
         written  consent of the Privileged  Party.  The rights and  obligations
         created by this paragraph apply to all information as to which, but for
         the  Distribution,  a party  would have been  entitled to assert or did
         assert the protection of a Privilege ("Privileged Information").

                  (b) Upon receipt by either party or any of its  Affiliates  of
         any subpoena,  discovery or other  request that arguably  calls for the
         production or disclosure of Privileged  Information of the other party,
         or if a party  obtains  knowledge  that any of its  current  or  former
         employees has received any  subpoena,  discovery or other request which
         arguably   calls  for  the   production  or  disclosure  of  Privileged
         Information  of the other  party,  the party will  promptly  notify the
         Privileged  Party of the  existence of the request and will provide the
         Privileged Party a reasonable opportunity to review the information and
         to assert any rights it may have under this Section 6.6 or otherwise to
         prevent the production or disclosure of Privileged Information. Neither
         party will produce or disclose  any  information  it should  reasonably
         expect to be covered by a


                                     - 14 -
<PAGE>


         Privilege  under this Section 6.6 unless (i) the  Privileged  Party has
         provided its express  written consent to such production or disclosure;
         or  (ii) a  court  of  competent  jurisdiction  has  entered  a  final,
         non-appealable  order finding that the  information  is not entitled to
         protection under any applicable privilege.

                  (c)  Either  party's  provision  of  information  to the other
         party,  and  either  party's  agreement  to permit  the other  party to
         possess copies of Privileged  Information  occurring or generated prior
         to the Distribution Date, are made in reliance on the agreement, as set
         forth  in  this  Section  6.6,  to  maintain  the   confidentiality  of
         Privileged  Information  and to  assert  and  maintain  all  applicable
         Privileges.  Any actions taken by either party in  connection  with the
         Distribution and this Separation Agreement shall not be deemed a waiver
         of any  Privilege  that has been or may be asserted by either party nor
         shall they operate to reduce,  minimize or condition the rights granted
         to either  party in, or the  obligations  imposed upon either party by,
         this Section 6.6.

                  (d) Agritope shall cause the Core Companies to comply with the
         restrictions imposed on it under this Section 6.6.

                  6.7      Technology.

                  (a) On or before the Distribution  Date,  Epitope shall assign
         to Agritope,  or as applicable Agritope shall assign to Epitope,  those
         patents,  patent applications,  trademarks or service marks and related
         applications, copyrights, trade secrets, licenses, or agreements listed
         on Schedule 1, which specifies the current owner or named party and the
         party to which they are to be  assigned.  Epitope  and  Agritope  shall
         cooperate  fully with each other to effect  the  assignments  and cause
         them to be made of record.  The assignee shall pay any recording costs,
         counsel fees, or similar charges incurred to cause the assignment to be
         made of record.

                  (b) After the Distribution Date, Epitope, on the one hand, and
         the Agritope  Units,  on the other,  may use the  patented  inventions,
         trademarks,   service  marks,  copyrighted  works,  trade  secrets,  or
         internally  developed or licensed  technology of the Agritope Units and
         of  Epitope,  respectively,  only to the  extent  permitted  by this or
         another written agreement.

                  (c)  For  a  period  not  to  exceed   two  years   after  the
         Distribution Date, Agritope may continue to use the E design registered
         trademark,  Reg. Nos. 1,770,765 and 1,805,488, in connection with goods
         and  services  of a quality  comparable  to those it provides as of the
         Distribution  Date.  Agritope shall use  reasonable  efforts to adopt a
         substitute  corporate  logo  within six months  after the  Distribution
         Date,  and  shall  phase out use of the E design  trademark  as soon as
         practicable.

                  (d) Epitope and Agritope will each make their  employees  (and
         employees of the Core Companies) reasonably available to cooperate with
         the other party in


                                     - 15 -
<PAGE>


         connection  with any patent  application  filed after the  Distribution
         Date if such employees have knowledge  relevant to the application.  If
         an employee of Epitope,  on the one hand, or the Agritope Units, on the
         other,  is an inventor of an invention  assigned to an Agritope Unit or
         to  Epitope,   respectively,   the  employer  will  make  the  employee
         reasonably  available to sign patent applications or related documents,
         testify in connection with patent interference or similar  proceedings,
         and take other actions  reasonably  requested by the assignee to obtain
         or maintain  patent or other rights in the  invention.  Nothing in this
         paragraph  requires the  assignment  of any invention to Epitope or the
         Agritope Units.

                                    ARTICLE 7
                                    INSURANCE

                  7.1  Transition.  Agritope  shall use  reasonable  efforts  to
obtain by and after  the  Distribution  Date  such  insurance  policies  for the
Agritope Business as the Agritope board of directors deems advisable,  and shall
keep Epitope  informed of all new insurance  policies  obtained by Agritope that
replace  Shared  Policies.  Epitope may have the Agritope Units removed as named
insureds from each Shared Policy  covering  losses of a type for which  Agritope
obtains its own insurance policy,  regardless of differences in the limits under
the Shared  Policy and the policy  obtained  by  Agritope.  Epitope may have the
Agritope  Units removed as named  insureds on each Shared Policy at the time the
Shared Policy next comes due for renewal.  For any period after the Distribution
Date  during  which an  Agritope  Unit  remains a named  insured  under a Shared
Policy,  Agritope  shall  pay  Epitope  a  pro  rata  portion  of  the  premiums
attributable to the period.

                  7.2  Post-Distribution  Date  Claims.  If,  subsequent  to the
Distribution Date, any person, corporation,  firm or entity shall assert a claim
against an Agritope Unit with respect to any injury, loss, liability,  damage or
expense incurred or claimed to have been incurred in, or in connection with, the
conduct of the  Agritope  Business  or, to the extent any claim is made  against
Agritope,  Epitope's  business,  and which injury,  loss,  liability,  damage or
expense may arise out of insured or insurable occurrences or events under one or
more of the Shared Policies, Epitope shall at the time such claim is asserted be
deemed to assign, without need of further documentation, to Agritope any and all
rights of an insured party under the applicable Shared  Policy(ies) with respect
to such  asserted  claim,  specifically  including  rights of indemnity  and the
right(s)  to be  defended  by or at the  expense  of the  insurer(s);  provided,
however,  that nothing in this  sentence is intended to  effectuate  or shall be
deemed to constitute or reflect the assignment of the Shared Policies, or any of
them, to Agritope.

                  7.3  Allocation  of  Insurance  Proceeds.  Insurance  Proceeds
received with respect to claims,  costs and expenses  under the Shared  Policies
shall be paid to Agritope with respect to Agritope's  Liabilities and to Epitope
with  respect to Epitope's  Liabilities.  Payment of the  allocable  portions of
indemnity costs of Insurance Proceeds resulting from the liability policies will
be made to the appropriate party upon receipt from the insurance carrier. In the
event that the aggregate limits on any of the Shared Policies are exceeded,  the
parties agree


                                     - 16 -
<PAGE>


to provide an equitable  allocation  of Insurance  Proceeds  received  after the
Distribution  Date based upon their  respective  bona fide  claims.  The parties
shall use their best efforts to cooperate with respect to insurance matters.

                                    ARTICLE 8
                               DISPUTE RESOLUTION

                  8.1 Negotiation and Binding  Arbitration.  Except with respect
to matters involving Section 6.6 hereof  (Privileged  Matters) and except as may
expressly be provided in any other  agreement  between the parties  entered into
pursuant hereto, if a dispute, controversy or claim (collectively,  a "Dispute")
between  Epitope  and  Agritope  arises out of or relates to this  Agreement,  a
Related  Agreement  or any  other  agreement  entered  into  pursuant  hereto or
thereto, including,  without limitation, the breach,  interpretation or validity
of any such agreement or any matter involving an Indemnifiable Loss, Epitope and
Agritope agree to use the following procedures, in lieu of either party pursuing
other  available  remedies and as the sole remedy (except as provided in Section
8.4 below), to resolve the Dispute.

                  8.2  Initiation.  A party  seeking to initiate the  procedures
will give written  notice to the other party,  briefly  describing the nature of
the Dispute.  A meeting  will be held between the parties  within 30 days of the
receipt of such notice,  attended by individuals with decision-making  authority
regarding the Dispute, to attempt in good faith to negotiate a resolution of the
Dispute.

                  8.3  Submission  to  Arbitration.  If,  not later than 30 days
after such meeting,  the parties have not succeeded in  negotiating a resolution
of the Dispute,  they will agree to submit the Dispute to binding arbitration in
accordance  with the Commercial  Arbitration  Rules of the American  Arbitration
Association,  by a sole arbitrator selected by the parties. The arbitration will
be held in  Portland,  Oregon,  and governed by the Federal  Arbitration  Act, 9
U.S.C. Sections 1-16, and judgment upon the award rendered by the arbitrator may
be entered by any court having  jurisdiction  thereof.  The costs of arbitration
will be apportioned between Epitope and Agritope as determined by the arbitrator
in such manner as the  arbitrator  deems  reasonable,  taking  into  account the
circumstances of the Dispute,  the conduct of the parties during the proceeding,
and the result of the arbitration.

                  8.4 Equitable  Relief.  Nothing  herein will  preclude  either
party from seeking  equitable relief to prevent any immediate,  irreparable harm
to its interests,  including multiple breaches of this Agreement or the relevant
Related Agreement by the other party. Otherwise,  these procedures are exclusive
and will be fully exhausted  prior to the initiation of any  litigation.  Either
party may seek specific  enforcement  of any  arbitrator's  decision  under this
Article. The arbitrator may consolidate an arbitration under this Agreement with
any arbitration arising under or relating to the Related Agreements or any other
agreement  between the parties entered into pursuant hereto, as the case may be,
if the subjects of the Disputes thereunder arise out of or relate essentially to
the same set of facts or transactions.  The  determination of issues relating to
consolidation and the determination of any such


                                     - 17 -
<PAGE>


consolidated  arbitration will be determined by the arbitrator appointed for the
arbitration proceeding that was commenced first in time.

                                    ARTICLE 9
                                  MISCELLANEOUS

                  9.1 Entire Agreement.  This Agreement,  including the Exhibits
and the agreements and other documents referred to herein,  shall constitute the
entire agreement between Epitope and Agritope with respect to the subject matter
hereof and shall supersede all previous  negotiations,  commitments and writings
with respect to such subject matter.

                  9.2 Expenses.  Except as otherwise  expressly provided in this
Agreement,  any Related  Agreement  or any other  agreement  being  entered into
between  Epitope and Agritope in  connection  with this  Agreement,  Epitope and
Agritope shall each pay their own costs and expenses incurred in connection with
the Distribution  and the consummation of the transactions  contemplated by this
Agreement. Agritope shall also pay the expenses of the Private Placement and the
expenses described on Schedule 2. Beginning December 1, 1997, Agritope shall pay
all costs and  expenses  incurred  in the course of the  Agritope  Business.  In
addition,  commencing  December  1, 1997,  Epitope  shall  furnish  services  to
Agritope,  and  Agritope  shall pay Epitope for such  services,  pursuant to the
Transition  Services and  Facilities  Agreement and "Shared  Services"  shall no
longer be allocated by Epitope to Agritope.  To the extent  expenses that are to
be borne by Agritope are advanced by Epitope,  Agritope shall reimburse  Epitope
for such  expenses,  without  interest,  within  five  business  days  after the
Distribution.

                  9.3 Governing Law. This Agreement,  the Related Agreements and
any other agreement entered into in connection with the  Distribution,  shall be
governed by, and  construed  and enforced in  accordance  with,  the laws of the
state of  Oregon  (regardless  of the laws that  might  otherwise  govern  under
applicable principles of conflict of laws).

                  9.4  Jurisdiction  and  Venue.   Subject  to  the  arbitration
provisions of this Agreement,  each party consents to the personal  jurisdiction
of the state and federal courts located in the state of Oregon and hereby waives
any argument that venue in any such forum is not convenient or proper.

                  9.5  Notices.  All  notices,   requests,   demands  and  other
communications  under this Agreement  shall be in writing and shall be deemed to
have been duly  given (i) on the date of  service  if served  personally  on the
party to whom  notice  is  given;  (ii) on the day of  transmission  if sent via
facsimile  transmission to the facsimile number given below, provided telephonic
confirmation of receipt is obtained  promptly after  completion of transmission;
(iii) on the business day after delivery to an overnight  courier service or the
express mail service  maintained by the United States Postal  Service,  provided
receipt of delivery has been confirmed;  or (iv) on the fifth day after mailing,
provided receipt of delivery is confirmed, if mailed to the party to whom notice
is to be given, by registered or


                                     - 18 -
<PAGE>


certified  mail,   postage  prepaid,   properly   addressed  and  return-receipt
requested, to the party as follows:

                  If to Epitope:            Epitope, Inc.
                                            8505 S.W. Creekside Place
                                            Beaverton, Oregon 97008
                                            Attn:  President
                                            Facsimile No. (503) 641-8665

                  If to Agritope:           Agritope, Inc.
                                            8505 S.W. Creekside Place
                                            Beaverton, Oregon 97008
                                            Attn:  President
                                            Facsimile No. (503) 520-6196

Any party may change its address and facsimile  number by giving the other party
written  notice of its new address and facsimile  number in the manner set forth
above.

                  9.6 Modification of Agreement.  No modification,  amendment or
waiver of any  provision of this  Agreement  shall be effective  unless the same
shall be in  writing  and  signed by each of the  parties  hereto  and then such
modification,  amendment  or  waiver  shall be  effective  only in the  specific
instance and for the purpose for which given.

                  9.7  Termination.  This  Agreement may be  terminated  and the
Distribution  abandoned at any time prior to the Record Date by, and in the sole
discretion  of, Epitope  without the approval of Agritope.  In the event of such
termination,  neither party (or any of its directors of officers) shall have any
liability of any kind to the other party.

                  9.8  Successors  and Assigns.  This  Agreement  and all of the
provisions  hereof shall be binding upon and inure to the benefit of the parties
and  their  respective  successors  and  permitted  assigns,  but  neither  this
Agreement nor any of the rights,  interests or  obligations  hereunder  shall be
assigned by either party without the prior  written  consent of the other party,
and such consent shall not be unreasonably withheld.

                  9.9 No Third Party  Beneficiaries.  Except for certain parties
entitled  to  indemnification  under  Sections  4.1 and 4.2  hereof  and  listed
therein,  this  Agreement is solely for the benefit of the parties hereto and is
not  intended to confer  upon any other  person  except the  parties  hereto any
rights or remedies hereunder.

                  9.10  Titles  and  Headings;  Interpretation.  The  titles and
headings to  articles  and  sections  herein are  inserted  for  convenience  of
reference  only and are not  intended to  constitute  a part of or to affect the
meaning or interpretation of this Agreement.


                                     - 19 -
<PAGE>


                  9.11  Exhibits.  The exhibits and schedules to this  Agreement
shall be construed  with and as an integral  part of this  Agreement to the same
extent as if the same had been set forth verbatim herein.

                  9.12  Severability.  In case any one or more of the provisions
contained in this Agreement  should be invalid,  illegal or  unenforceable,  the
enforceability  of the  remaining  provisions  hereof  shall  not in any  way be
affected or impaired thereby.

                  9.13 No Waiver.  Neither the failure nor any delay on the part
of any party hereto to exercise any right under this Agreement  shall operate as
a waiver thereof, nor shall any single or partial exercise of any right preclude
any other or  further  exercise  of the same or any other  right,  nor shall any
waiver of any right with respect to any  occurrence  be construed as a waiver of
such right with respect to any other occurrence.

                  9.14  Survival.  All covenants  and  agreements of the parties
contained  in  this  Agreement   will  survive  for  ten  years   following  the
Distribution Date, except for the covenants and agreements  contained in Section
6.6, which shall continue indefinitely.

                  9.15  Counterparts.  This  Agreement may be executed in two or
more counterparts,  all of which shall be considered one and the same agreement,
and shall become a binding  agreement when a counterpart has been signed by each
party and delivered to the other party.

                  IN WITNESS  WHEREOF,  the  parties  hereto  have  caused  this
Agreement to be executed  delivered on their behalf as of the date first written
above.


                                       EPITOPE, INC.

                                       By     /s/ John W. Morgan

                                       Title  President and CEO


                                       AGRITOPE, INC.

                                       By     /s/ Adolph J. Ferro

                                       Title  Chairman, President and CEO





                                     - 20 -
<PAGE>


                  The undersigned  consent to and agree to be bound by the terms
of this Agreement.

                                       VINIFERA, INC.

                                       By     /s/ Gilbert N. Miller

                                       Title  Exec Vice President


                                       AGRIMAX FLORAL PRODUCTS, INC.

                                       By     /s/ Gilbert N. Miller

                                       Title  Exec Vice President






                                     - 21 -
<PAGE>


                                   SCHEDULE 1

                      INTELLECTUAL PROPERTY TO BE ASSIGNED

NONE



                                     - 22 -

<PAGE>



                                   SCHEDULE 2

                            CERTAIN AGRITOPE EXPENSES

         1. Miller Nash fees and expenses for  Agritope  Stock  Purchase and R&D
Agreements of $12,408.

         2. All Tonkon Torp fees and expenses

         3. Travel  expenses for Dr. Ferro and Mr.  Miller for June,  September,
and  November  trips to Europe made in  connection  with  private  placement  of
Agritope Stock Purchase and R&D Agreements.

         4.       Capital Asset Acquisitions

                  - Precision Computers -- Pentium PC          $  2,734
                  - Computer System, CD Player                      699
                  - HP Gas Chromatograph                         21,208
                  - APCO Technologies Grafting Machine           10,000

         5.       Prepaid rent on new Agritope facility        $ 21,445
         ==                                                    ========





                                     - 23 -
<PAGE>


                                    EXHIBIT A

                          [EMPLOYEE BENEFITS AGREEMENT]


                                    EXHIBIT B

                           [TAX ALLOCATION AGREEMENT]


                                    EXHIBIT C

                 [TRANSITION SERVICES AND FACILITIES AGREEMENT]




                                     - 24 -


                                 RESTATED BYLAWS

                                       OF

                                  EPITOPE, INC.

                                    ARTICLE I

                                  Shareholders
                                  ------------

         Section 1. Annual  Meeting.  The annual meeting of the  shareholders of
the  corporation  shall be held each year on a date  designated  by the Board of
Directors, for the purpose of electing directors and for the transaction of such
other business as may come before the meeting.  In case of incomplete  financial
or other  information,  unavailability of shareholders,  directors,  officers or
other persons  whose  attendance  at the annual  meeting would be desirable,  or
other similar  circumstances,  the president in his  discretion may postpone the
annual  meeting.  If the annual  meeting is  postponed,  or if the  election  of
directors shall not be held on the day designated  herein for any annual meeting
of the shareholders,  or at any adjournment  thereof, a special meeting shall be
held as soon as may be convenient as determined by the president, either in lieu
of the annual meeting if the annual meeting was postponed or for the election of
directors  if the  election  was  not  held  at  the  annual  meeting  or at any
adjournment thereof. Written or printed notice, stating the place, day, hour and
purpose of the special  meeting  shall be  delivered  not less than ten nor more
than sixty days before the date of the special meeting,  either personally or by
mail, by the president or, at the direction of the  president,  by the secretary
to each shareholder of record entitled to vote at the meeting.  If mailed,  such
notice shall be deemed to be delivered when deposited in the United States mails
addressed to the  shareholder at his address as it appears on the stock transfer
books of the corporation, with postage thereon prepaid.

         Section 2. Special  Meetings.  Special meetings of the shareholders may
be called for any purpose or purposes by the president,  the Board of Directors,
the holders of not less than one-tenth (1/10) of all the shares entitled to vote
at the meeting or as provided in the Oregon Business  Corporation Act. Notice of
special  meetings  shall be given by the  president  or, at the direction of the
president, by the secretary or assistant secretary to each shareholder of record
entitled to vote at such meetings in the same manner as hereinabove  provided in
Section 1 of this Article.

         Section  3.  Place of  Meeting.  Meetings,  annual or  special,  of the
shareholders  shall be held at such place either  within or without the state of
Oregon as shall be designated  by the Board of  Directors,  or in the absence of
such a designation, at the main office of the corporation.

         Section  4.  Quorum;  Waiver of Notice.  A  proposal  voted upon by the
shareholders,  other than the  election of  directors,  shall be approved if the
votes cast favoring the matter exceed the votes cast opposing the matter, unless
the corporation's articles of incorporation, bylaws, or


                                      - 1 -
<PAGE>


applicable  provisions of the Oregon Business  Corporation Act require a greater
number of affirmative votes. If a quorum be not present at any annual or special
meeting, a majority of the shareholders  present,  either in person or by proxy,
may adjourn to such time and place as may be decided  upon by the holders of the
majority of the shares present, and notice of such adjournment shall be given in
accordance  with  Section  4 of  this  Article;  but  if a  quorum  be  present,
adjournment  may be taken  from day to day or to such  time and  place as may be
decided by the holders of the majority of the shares  present,  and no notice of
such  adjournment need be given. No business shall be transacted at an adjourned
meeting  that  could not have been  transacted  at the  meeting  from  which the
adjournment  was taken.  Whenever any notice is required to be given pursuant to
statute, to the articles of incorporation,  or to these bylaws, a waiver thereof
signed by the shareholder  entitled to notice,  whether before or after the time
stated therein,  shall be deemed equivalent thereto. Any shareholder attending a
meeting without  objection thereof shall be deemed to have waived notice of such
meeting.  Notice  otherwise  complying  with the  terms  hereof  may be given by
prepaid telegram as the equivalent of notice by mail.

         Section 5. Proxies. At all meetings of shareholders,  a shareholder may
vote by proxy executed in writing by the  shareholder or by his duly  authorized
attorney  in  fact.  Such  proxy  shall  be  filed  with  the  secretary  of the
corporation before or at the time of the meeting.  No proxy shall be valid after
11 months  from the date of its  execution,  unless  otherwise  provided  in the
proxy.

                                   ARTICLE II

                               Board of Directors
                               ------------------

         Section  1.  Board  of  Directors.  The  business  and  affairs  of the
corporation shall be managed by a Board of Directors.

         Section 2. Meetings. A regular annual meeting of the Board of Directors
shall be held immediately after, and at the same place as, the annual meeting of
shareholders.  No notice of the  annual  meeting  other  than this bylaw need be
given  unless the meeting is to be held at a place other than the main office of
the corporation,  in which case the notice shall be given in the manner provided
in Section 1 of Article I of these restated  bylaws.  The Board of Directors may
provide, by resolution, the time and place for the holding of additional regular
meetings  without  other notice than such  resolution.  Special  meetings of the
Board of  Directors  may be called by or at the request of the  president or any
director.  Notice of any special  meeting shall be given at least three (3) days
prior thereto by oral notice given in person, by telephone, or by other means of
oral electronic two-way communication, or by written notice delivered personally
or sent by mail, courier, fax, or similar means to the director's residential or
business  address.  Directors  may  waive  notice  of  meetings  of the Board of
Directors,  and a waiver  thereof  signed by the  director  entitled  to notice,
whether  before or after the time  stated  therein,  shall be deemed  equivalent
thereto.  Attendance  of a director at a meeting  shall  constitute  a waiver of
notice of such  meeting,  except where the director  attends the meeting for the
express  purpose of objecting  to the  transaction  of any business  because the
meeting is not lawfully called or convened.


                                      - 2 -
<PAGE>


         Section 3.  Quorum and  Voting.  A majority  of the  elected and acting
directors shall  constitute a quorum for the transaction of business.  If at any
meeting of the Board of Directors there shall be less than a quorum  present,  a
majority of the  directors  present may adjourn to such time and place as may be
decided  upon by the  majority  of the  directors  present,  and  notice of such
adjournment shall be given in accordance with Section 2 of this Article;  but if
a quorum be  present,  adjournment  may be taken from day to day or to such time
and place as may be decided by the  majority of the  directors  present,  and no
notice of such  adjournment need be given.  When a quorum exists,  action may be
taken by a majority vote of the directors present.

         Section 4. Notification of Nominations. Nominations for the election of
directors may be made by the Board of Directors or a proxy  committee  appointed
by the Board of Directors or by a  shareholder  entitled to vote in the election
of  directors  generally.  However,  any  shareholder  entitled  to  vote in the
election of directors generally may nominate one or more persons for election as
directors at a meeting only if written  notice of such  shareholder's  intent to
make such nomination or nominations has been given,  either by personal delivery
or by United States mail,  postage prepaid,  to the secretary of the corporation
not later than (a) with  respect to an election to be held at an annual  meeting
of  shareholders,  60 days in advance of the date of the previous  year's annual
meeting of  shareholders,  and (b) with  respect to an  election to be held at a
special  meeting of  shareholders  for the election of  directors,  the close of
business on the seventh day  following  the date on which notice of such meeting
is first given to  shareholders.  Each such notice shall set forth: (i) the name
and address of the  shareholder  who intends to make the  nomination  and of the
person or persons to be nominated; (ii) a representation that the shareholder is
a holder of record of stock of the corporation  entitled to vote at such meeting
and  intends  to appear in person or by proxy at the  meeting  to  nominate  the
person  or  persons  specified  in  the  notice;  (iii)  a  description  of  all
arrangements or understandings  between the shareholder and each nominee and any
other person or persons  (naming  such person or persons)  pursuant to which the
nomination or nominations are to be made; (iv) such other information  regarding
each nominee proposed by such shareholder as would be required to be included in
a proxy statement filed with the Securities and Exchange  Commission pursuant to
the Securities  Exchange Act of 1934,  and the related proxy  regulations of the
Securities and Exchange Commission promulgated thereunder,  had the nominee been
nominated, or intended to be nominated,  by the Board of Directors;  and (v) the
consent of each nominee to serve as a director of the corporation if so elected.
The  chairman of the meeting may refuse to  acknowledge  the  nomination  of any
person not made in compliance with the foregoing procedure.

                                   ARTICLE III

                               Executive Committee
                               -------------------

         The  majority  of the  Board of  Directors  may  designate  two or more
directors to constitute an executive committee, which committee between meetings
of the Board of Directors  shall have and may exercise all of the  authority and
powers of the Board of Directors in the  management  of the business and affairs
of  the   corporation,   except  that  the  committee  may  not:  (a)  authorize
distributions,  except as permitted by clause (g) below;  (b) approve or propose
to shareholders


                                      - 3 -
<PAGE>


actions  that the Oregon  Business  Corporation  Act  requires to be approved by
shareholders;  (c) fill  vacancies  on the board of  directors  or on any of its
committees; (d) amend the articles of incorporation,  except as permitted by the
Oregon Business Corporation Act; (e) adopt, amend, or repeal bylaws; (f) approve
a plan of merger not requiring  shareholder  approval;  (g) authorize or approve
reacquisition  of  shares,  except  within  limits  prescribed  by the  board of
directors; (h) authorize or approve the issuance or sale or contract for sale of
shares or  determine  the  designation  and  relative  rights,  preferences  and
limitations  of a class or series of shares,  except as  permitted by the Oregon
Business Corporation Act; or (i) appoint or remove officers of the corporation.

                                   ARTICLE IV

                               Officers and Agents
                               -------------------

         Section 1. Executive Officers.

                  (a) Number: The officers of the corporation shall consist of a
         chairman of the board, president,  chief executive officer, that number
         of vice  presidents  which the Board of Directors may from time to time
         determine and with such designations and seniority as the directors may
         assign,  a secretary  and a  treasurer.  Any two or more offices may be
         held by one person.

                  (b) Election and Tenure: The officers of the corporation shall
         be elected at the organizational meeting and thereafter at each regular
         annual meeting. In the event of a failure to hold the annual meeting as
         herein  provided,  officers may be elected at any time  thereafter at a
         special  meeting of  directors  called for that  purpose.  Each officer
         shall  hold  office  for the term of one year and until  his  successor
         shall be elected except where  expressly  provided to the contrary in a
         contract authorized by the Board of Directors.  All officers and agents
         shall be subject  to  removal at any time by the vote of a majority  of
         the entire Board of Directors whenever in the judgment of the directors
         the best interests of the  corporation  will be served by such removal,
         without  prejudice,  however,  to any contract  rights of the person so
         removed.

                  (c) Vacancies:  A vacancy in any office shall be filled by the
         Board of Directors at any regular  meeting,  or at any special  meeting
         called for that purpose.

                  (d) Additional Officers and Agents: The Board of Directors may
         also elect one or more  assistant  secretaries,  one or more  assistant
         treasurers, and such other officers or agents as it may deem necessary,
         with such  authority  and duties as from time to time may be prescribed
         by the Board of Directors.

         Section 2. Chairman of the Board.  The chairman of the board, if one is
elected by the Board of Directors,  shall preside at and conduct all meetings of
the shareholders and


                                      - 4 -
<PAGE>


directors. The chairman of the board may designate another officer to preside at
and conduct any such  meeting in his  absence.  The  chairman of the board shall
exercise  such other powers and perform such other duties as shall be prescribed
by the directors from time to time.

         Section 3. Chief Executive  Officer.  The chief executive officer shall
have  general  and  active  charge  of  the  business  and   management  of  the
corporation, subject to control by the Board of Directors. In the absence of the
chairman of the board or another officer designated by the chairman of the board
at any meeting of the shareholders or the directors, the chief executive officer
or another officer  designated by the chief  executive  officer shall preside at
the meeting.  The chief executive officer is authorized to sign all certificates
of stock, and all deeds, leases, notes, mortgages and contracts, including those
in any way  affecting  real  property or interests  therein,  as the same may be
required in the regular course of the corporation's  business. He shall have the
power to appoint and discharge agents and employees,  subject to approval of the
Board of Directors.

         Section 4.  President.  The  president  shall  exercise such powers and
perform  such duties as may be  prescribed  by the Board of  Directors or by the
chief  executive  officer.  In the absence or incapacity of the chief  executive
officer,  and at the  direction of the Board of  Directors,  he is authorized to
sign all  certificates of stock,  and all deeds,  leases,  notes,  mortgages and
contracts,  including  those in any way  affecting  real  property or  interests
therein,  as the same may be required in the regular course of the corporation's
business.

         Section  5.  Vice  Presidents.  The vice  presidents,  in the  order of
seniority  as  designated  by the Board of  Directors,  shall in the  absence or
disability  of the  president  exercise the powers and perform the duties of the
president. Each vice president shall also exercise such other powers and perform
such other duties as shall be prescribed by the  directors,  and such powers and
duties of the president as may be designated by the president.

         Section 6. Secretary. The secretary shall give such notices of meetings
of the  shareholders and of the Board of Directors as required by these restated
bylaws,  and shall keep a record of the  proceedings of all such meetings.  Such
record shall be kept at the principal or registered  office of the  corporation.
He shall have custody of all books and records and papers of the company  except
those which are in the care of the treasurer or some other person  authorized to
have custody and possession thereof by resolution of the Board of Directors.  He
shall, with the president, sign all certificates of stock of the corporation and
shall affix the seal of the  corporation to such  certificates  of stock.  He is
authorized  to sign  with the  president  or vice  president  in the name of the
corporation all deeds, notes, mortgages and contracts including those in any way
affecting  real  property or  interests  therein and shall affix the seal of the
corporation  thereto when required in the regular  course of business.  He shall
submit such  reports to the Board of  Directors as may be requested by them from
time to time.

         Section 7. Assistant  Secretary.  The assistant secretary shall, in the
absence or  disability  of the  secretary,  exercise  the powers and perform the
duties of the  secretary.  He shall also  exercise such other powers and perform
such other duties as may be prescribed by the


                                      - 5 -
<PAGE>


Board of  Directors  and such  powers  and  duties  of the  secretary  as may be
designated by the president or secretary.

         Section 8.  Treasurer.  The treasurer shall from time to time make such
reports to the officers, Board of Directors and shareholders as may be required,
and shall perform such other duties as the Board of Directors shall from time to
time delegate to him.

         Section 9. Assistant  Treasurer.  The assistant treasurer shall, in the
absence or  disability  of the  treasurer,  exercise  the powers and perform the
duties of the  treasurer.  He shall also  exercise such other powers and perform
such other duties as may be prescribed by the Board of Directors and such powers
and duties of the treasurer as may be designated by the president or treasurer.

                                    ARTICLE V

         Section 1. Right to  Indemnification.  The corporation  shall indemnify
any director or former  director of the  corporation  or any person who may have
served at its  request as a director  of  another  corporation  in which it owns
shares  of  capital  stock or of which it is a  creditor  against  expenses  and
liability actually and necessarily  incurred by such director in connection with
any threatened,  pending or completed action, suit or proceeding, whether civil,
criminal,  administrative  or investigative  and whether formal or informal,  in
which such director is a party by reason of being or having been such  director,
except in relation to matters as to which  indemnification  is prohibited by the
Oregon  Business  Corporation  Act as it shall be amended from time to time (the
"Act");  but such  indemnification  shall not be deemed  exclusive  of any other
rights to which such  director  may be  entitled,  under any  bylaw,  agreement,
general or specific  action of the Board of Directors,  vote of  shareholders or
otherwise.  As  used  herein,  "expenses"  shall  include,  without  limitation,
expenses of investigations, arbitrations, mediations, judicial or administrative
proceedings  or appeals,  attorney  fees and  disbursements  and any expenses of
establishing  a  right  to   indemnification.   "Liability"  shall  include  the
obligation to pay a judgment, settlement, penalty, fine, including an excise tax
assessed  with  respect to an employee  benefit  plan,  or  reasonable  expenses
incurred with respect to an arbitration,  mediation,  action, suit or proceeding
in which a director is entitled to indemnification hereunder.

         Section 2. Procedure for  Indemnification.  After the final disposition
of any threatened, pending or completed arbitration,  mediation, action, suit or
proceeding, whether civil, criminal, administrative or investigative and whether
formal or informal, in which a director may be entitled to indemnification, such
director may send to the corporation a written request for indemnification.  The
corporation  shall,  in accordance  with the provisions of the Act regarding the
determination and authorization of  indemnification,  make a finding whether the
indemnification  requested  is  permitted  by the laws of the state of Oregon no
later than 60 days following  receipt by the  corporation  of such request.  The
corporation shall cause the indemnification  requested to be authorized and paid
unless  the  corporation  finds  that the  indemnification  requested  is not so
permitted. The director shall be given an opportunity to be heard and to present
evidence  in  connection  with  the   consideration  of  the  party  or  parties
determining the right to indemnification  under the Act. If the corporation does
not authorize


                                      - 6 -
<PAGE>


indemnification   hereunder,   the  director   shall  have  the  right  to  seek
court-ordered  indemnification  in accordance with the provisions of the Act. In
any such action,  neither the making of, nor the failure to make, any finding by
the corporation that  indemnification of the director is proper or not proper in
the circumstances shall be a defense to such action or create a presumption that
the director has not met the standard of conduct  required by the Act. In making
its determination  and in any court  proceeding,  the corporation shall have the
burden  of  proving  that the  director  has not met the  standards  of  conduct
required by the Act to authorize indemnification.

         Section 3. Procedure for Advancement of Expenses. The corporation shall
pay for or reimburse the reasonable  expenses incurred by a director as a result
of being party to a  threatened,  pending or completed  arbitration,  mediation,
action,  suit  or  proceeding,   whether  civil,  criminal,   administrative  or
investigative and whether formal or informal, in advance of final disposition of
such arbitration, mediation, action, suit or proceeding promptly upon receipt of
a written  request  for  payment of such  expenses  that is in  accordance  with
requirements of the Act for such written statement. Such written statement shall
also include or be accompanied by  documentation  of the expenses  incurred and,
when available,  such documentation of expenses shall include copies of bills or
statements  evidencing  the  expenses  incurred.  If the  requirements  of  this
provision  are met,  the  corporation  shall pay the amount  requested  promptly
notwithstanding   the  absence  of  a  final  disposition  of  the  arbitration,
mediation, action, claim or proceeding.

         Section 4.  Indemnification  of  Officers,  Employees  and Agents.  The
corporation may, by action of its Board of Directors from time to time,  provide
indemnification  and pay  expenses  in  advance  of the final  disposition  of a
proceeding  to officers,  employees  and agents of the  corporation  to the same
extent  and  effect  as  provided   in  this   Article   with   respect  to  the
indemnification  and  advancement of expenses of directors of the corporation or
pursuant to rights granted pursuant to, or provided by, the Act or otherwise.

         Section 5. Insurance.  The  corporation  may, but shall not be required
to,  purchase and keep in force a policy or policies of  liability  insurance on
behalf of its officers and directors  against liability and expenses incurred in
any arbitration, mediation, action, suit or proceeding, whether civil, criminal,
administrative or investigative and whether formal or informal.

         Section  6.  Nonexclusivity;  Nature  of  Rights.  The  indemnification
provided  herein shall not be deemed  exclusive  of any other rights  consistent
with the laws of the state of Oregon to which a director  may be entitled  under
the corporation's articles of incorporation, bylaws or any other agreement, vote
of  shareholders,  or otherwise,  both as to action in the  director's  official
capacity and as to action in another  capacity while holding  office,  and shall
continue  notwithstanding that the director may have ceased to be connected with
the  corporation.  The right of  indemnification  provided  for herein  shall be
deemed  to  create   contractual  rights  in  favor  of  directors  entitled  to
indemnification  hereunder and shall be applicable to claims commenced after the
adoption  hereof,  whether  arising from acts or omissions  occurring  before or
after the adoption hereof. The right of indemnification  provided for herein may
not be amended or


                                      - 7 -
<PAGE>


repealed so as to limit in any way the indemnification  provided for herein with
respect  to any acts or  omissions  occurring  prior to any  such  amendment  or
repeal.

                                   ARTICLE VI

                            Action Without a Meeting
                            ------------------------

         Section 1. Written  Consent.  Any action  required to be taken or which
may be taken at a meeting of the  shareholders or directors may be taken without
a meeting  if a consent in writing  setting  forth the action so taken  shall be
signed  by all of the  shareholders  or  directors  entitled  to vote;  and such
consent  shall  have the same  force  and  effect  as a  unanimous  vote of such
shareholders or directors.

         Section 2. Electronic  Communications.  The Board of Directors,  or any
committee designated by the directors,  may hold any meeting of the directors or
committee,  by  means  of  a  conference  telephone  or  similar  communications
equipment  by  means of which  all  persons  participating  in the  meeting  can
simultaneously hear each other. Participation in such a meeting shall constitute
presence in person at the meeting.

                                   ARTICLE VII

         Section 1.  Certificates.  Shares of stock of the corporation  shall be
represented by stock  certificates which shall be in a form adopted by the Board
of Directors, provided all such stock certificates within one series of the same
class of stock shall be  consecutively  numbered,  and shall  express upon their
face the number  thereof,  the date of issuance,  the number of shares for which
and the person to whom issued and the class and series, if any, thereof, and all
such stock certificates shall be signed by the president or a vice president and
by the  secretary or assistant  secretary  and may be sealed with the  corporate
seal, if any. In addition, each certificate shall express upon its face that the
corporation  is  organized  under the laws of the state of Oregon and shall also
express the par value of the shares  represented  by the  certificate,  or shall
state  that the shares  are  without  par  value,  as may be  appropriate.  Each
certificate  shall state upon the face or back  thereof,  in full or in summary,
all of the designations,  preferences, limitations, restrictions on transfer and
relative rights of the shares of each class and series  authorized to be issued,
or shall indicate where such information may be found.

         Section  2.  Subscriptions.  Subscriptions  for  shares of stock of the
corporation  shall be paid in full at such time, or in such  installments and at
such times,  as the Board of Directors may determine.  In case of default in the
payment  of any  installment  or call when  such  payment  is due,  the Board of
Directors may declare the shares and all previous payments thereon forfeited for
the use of the  corporation,  in the manner  prescribed  by the Oregon  Business
Corporation Act.

         Section 3.  Transfer of Shares.  Transfer of shares of the  corporation
shall be made only on the stock transfer books of the  corporation by the holder
of record  thereof  or by his legal  representative,  who shall  furnish  proper
evidence of authority to transfer, or by his attorney


                                      - 8 -
<PAGE>


thereunto  authorized  by power of  attorney  duly  executed  and filed with the
secretary  of  the  corporation,  and  on  surrender  for  cancellation  of  the
certificate for such shares.  The person in whose name shares stand on the books
of the  corporation  shall be deemed by the  corporation to be owner thereof for
all purposes. All certificates surrendered to the corporation for transfer shall
be canceled and no new certificate shall be issued until the former  certificate
for a like number of shares shall have been  surrendered  and  canceled,  except
that in case of a lost,  destroyed  or  mutilated  certificate  a new one may be
issued therefor upon such terms and indemnity to the corporation as the Board of
Directors may  prescribe.  The record of  shareholder  and stock  transfer books
shall be kept at the principal or registered office of the corporation or at the
office of its transfer agent or registrar, if any.

                                  ARTICLE VIII

                                   Amendments
                                   ----------

         Bylaws may be adopted,  altered,  amended or  repealed,  in whole or in
part, at any regular or special meeting of the Board of Directors.

         Approved by the Board of Directors December 17, 1996.

         Amended April 28, 1997.


                                      - 9 -


                                  EPITOPE, INC.

                   AMENDED AND RESTATED 1991 STOCK AWARD PLAN

                                    ARTICLE 1
                            ESTABLISHMENT AND PURPOSE

                  1.1 Establishment;  Amendment and Restatement.  Epitope,  Inc.
("Corporation"),  hereby  establishes  the Epitope,  Inc., 1991 Stock Award Plan
(the "Plan"),  effective as of January 8, 1991, subject to shareholder  approval
as  provided  in  Article  17.  The Plan was  previously  amended  and  restated
effective March 25, 1991,  December 8, 1992, December 14, 1993, and December 13,
1994, and is further amended and restated as set forth herein effective December
17, 1996.

                  1.2 Purpose. The purpose of the Plan is to promote and advance
the interests of Corporation  and its  shareholders  by enabling  Corporation to
attract,  retain, and reward key employees,  outside advisors,  and directors of
Corporation  and  its  subsidiaries.  It is  also  intended  to  strengthen  the
mutuality of interests  between such  employees,  advisors,  and  directors  and
Corporation's shareholders. The Plan is designed to meet this intent by offering
stock  options and other  equity-based  incentive  awards,  thereby  providing a
proprietary  interest in  pursuing  the  long-term  growth,  profitability,  and
financial success of Corporation.

                                    ARTICLE 2
                                   DEFINITIONS

                  2.1 Defined  Terms.  For purposes of the Plan,  the  following
terms shall have the meanings set forth below:

                  "ADVISOR"   means  a  member  of  an  Advisory   Committee  of
Corporation or a Subsidiary,  or any other consultant selected by the Committee,
who is neither an employee of  Corporation  or a Subsidiary  nor a  Non-Employee
Director.

                  "ADVISORY  COMMITTEE" means a scientific advisory committee to
Corporation or a Subsidiary.

                  "AGRITOPE SHARE" means a share of Agritope Stock.

                  "AGRITOPE STOCK PROPOSAL DATE" means the effective date of the
amendment of  Corporation's  Articles of  Incorporation to create Agritope Stock
and to redesignate  Corporation's  previously  existing  common stock as Medical
Products Stock.

                  "AGRITOPE  STOCK"  means the  Agritope  Common  Stock,  no par
value,  of Corporation or any security of  Corporation  issued in  substitution,
exchange, or in lieu of such stock.

                  "AWARD"  means  an award or  grant  made to a  Participant  of
Options,  Stock Appreciation Rights,  Restricted Awards,  Performance Awards, or
Other Stock-Based Awards pursuant to the Plan.

                  "AWARD  AGREEMENT"  means an agreement as described in Section
6.4.

                  "BOARD" means the Board of Directors of Corporation.


                                      - 1 -
<PAGE>


                  "CODE" means the Internal Revenue Code of 1986, as amended and
in effect from time to time,  or any  successor  thereto,  together  with rules,
regulations,  and interpretations  promulgated thereunder.  Where the context so
requires, any reference to a particular Code section shall be construed to refer
to the successor provision to such Code section.

                  "COMMITTEE"  means  the  committee  appointed  by the Board to
administer the Plan as provided in Article 3 of the Plan.

                  "COMMON  STOCK"  means the  Common  Stock,  no par  value,  of
Corporation or any security of Corporation issued in substitution,  exchange, or
in lieu of such stock.  For all periods after the Agritope  Stock Proposal Date,
references in this Plan to Common Stock include either Agritope  Stock,  Medical
Products Stock, or both, as the context may require.

                  "CONTINUING  RESTRICTION"  means a  Restriction  contained  in
Sections  6.5(h),  16.4,  16.5, and 16.7 of the Plan and any other  Restrictions
expressly  designated  by the  Committee  in an Award  Agreement as a Continuing
Restriction.

                  "CORPORATION" means Epitope,  Inc., an Oregon corporation,  or
any successor corporation.

                  "DEFERRED  COMPENSATION  OPTION" means a  Nonqualified  Option
granted  with an option  price less than Fair Market  Value on the date of grant
pursuant to Section 7.9 of the Plan.

                  "DISABILITY"  means the condition of being  "disabled"  within
the meaning of Section 422(c)(7) of the Code. However,  the Committee may change
the foregoing definition of "Disability" or may adopt a different definition for
purposes of specific Awards.

                  "EXCHANGE ACT" means the  Securities  Exchange Act of 1934, as
amended and in effect from time to time,  or any  successor  statute.  Where the
context so requires,  any reference to a particular section of the Exchange Act,
or to any rule  promulgated  under the Exchange Act, shall be construed to refer
to successor provisions to such section or rule.

                  "FAIR  MARKET  VALUE"  means with  respect to either  Agritope
Shares or Medical  Products  Shares,  on a particular day, without regard to any
restrictions  (other than a restriction  which, by its terms, will never lapse),
the mean between the reported high and low sale prices,  or, if there is no sale
on such day, the mean between the  reported bid and asked  prices,  of Shares of
the applicable  class on that day or, if that day is not a trading day, the last
prior  trading  day,  on  the  securities   exchange  or  automated   securities
interdealer quotation system on which such Shares shall have been traded.

                  "INCENTIVE  STOCK  OPTION" or "ISO"  means any Option  granted
pursuant to the Plan that is intended to be and is  specifically  designated  in
its Award Agreement as an "incentive stock option" within the meaning of Section
422 of the Code.

                  "MEDICAL  PRODUCTS  SHARE"  means a share of Medical  Products
Stock.

                  "MEDICAL  PRODUCTS STOCK" means the Epitope  Medical  Products
Common Stock, no par value, of Corporation or any security of Corporation issued
in substitution, exchange, or in lieu of such stock.

                  "NON-EMPLOYEE DIRECTOR" means a member of the Board who is not
an employee of Corporation or any Subsidiary.

                  "NONQUALIFIED  OPTION" or "NQO" means any Option,  including a
Deferred  Compensation  Option,  granted  pursuant  to the  Plan  that is not an
Incentive Stock Option.

                  "OPTION"  means an ISO,  an NQO,  or a  Deferred  Compensation
Option.


                                      - 2 -
<PAGE>


                  "OTHER STOCK-BASED AWARD" means an Award as defined in Section
11.1.

                  "PARTICIPANT"   means  an   employee  of   Corporation   or  a
Subsidiary, an Advisor, or a Non-Employee Director who is granted an Award under
the Plan.

                  "PERFORMANCE  AWARD"  means an Award  granted  pursuant to the
provisions  of Article 10 of the Plan,  the  Vesting of which is  contingent  on
performance attainment.

                  "PERFORMANCE  CYCLE"  means a  designated  performance  period
pursuant to the provisions of Section 10.3 of the Plan.

                  "PERFORMANCE  GOAL" means a designated  performance  objective
pursuant to the provisions of Section 10.4 of the Plan.

                  "PLAN" means this  Epitope,  Inc.,  1991 Stock Award Plan,  as
amended and restated  and set forth  herein and as it may be  hereafter  amended
from time to time.

                  "REPORTING  PERSON" means a Participant  who is subject to the
reporting requirements of Section 16(a) of the Exchange Act.

                  "RESTRICTED  AWARD" means a  Restricted  Share or a Restricted
Unit granted pursuant to Article 9 of the Plan.

                  "RESTRICTED  SHARE" means an Award described in Section 9.1(a)
of the Plan.

                  "RESTRICTED UNIT" means an Award of units representing  Shares
described in Section 9.1(b) of the Plan.

                  "RESTRICTION"  means a  provision  in the  Plan or in an Award
Agreement which limits the exercisability or  transferability,  or which governs
the  forfeiture,  of an Award or the Shares,  cash,  or other  property  payable
pursuant to an Award.

                  "RETIREMENT" means:

                  (a) For Participants who are employees, retirement from active
         employment with Corporation and its Subsidiaries at or after age 50, or
         such earlier  retirement date as approved by the Committee for purposes
         of the Plan;

                  (b)  For   Participants   who  are   Non-Employee   Directors,
         termination of membership on the Board after  attaining age 50, or such
         earlier  retirement  date as approved by the  Committee for purposes of
         the Plan; and

                  (c) For Participants who are Advisors,  termination of service
         as an Advisor after  attaining age 50, or such earlier  retirement date
         as approved by the Committee for purposes of the Plan.

However,  the Committee may change the foregoing  definition of  "Retirement" or
may adopt a different definition for purposes of specific Awards.

                  "SHARE" means a share of Common  Stock.  For all periods after
the Agritope  Stock  Proposal  Date,  references in this Plan to Shares  include
either Agritope Shares,  Medical  Products  Shares,  or both, as the context may
require.

                  "STOCK  APPRECIATION RIGHT" or "SAR" means an Award to benefit
from the  appreciation  of Common Stock  granted  pursuant to the  provisions of
Article 8 of the Plan.


                                      - 3 -
<PAGE>


                  "SUBSIDIARY"  means a "subsidiary  corporation" of Corporation
within the meaning of Section 425 of the Code,  namely any  corporation in which
Corporation  directly  or  indirectly  controls  50 percent or more of the total
combined voting power of all classes of stock having voting power.

                  "VEST" or "VESTED" means:

                  (a) In the case of an Award that requires  exercise,  to be or
         to  become   immediately   and  fully   exercisable  and  free  of  all
         Restrictions (other than Continuing Restrictions);

                  (b) In the case of an Award that is subject to forfeiture,  to
         be or to become  nonforfeitable,  freely transferable,  and free of all
         Restrictions (other than Continuing Restrictions);

                  (c) In the case of an Award that is  required  to be earned by
         attaining  specified  Performance  Goals, to be or to become earned and
         nonforfeitable,  freely  transferable,  and  free  of all  Restrictions
         (other than Continuing Restrictions); or

                  (d) In the case of any other Award as to which  payment is not
         dependent solely upon the exercise of a right,  election,  exercise, or
         option,  to be  or to  become  immediately  payable  and  free  of  all
         Restrictions (except Continuing Restrictions).

                  2.2 Gender and Number. Except where otherwise indicated by the
context,  any  masculine  or  feminine  terminology  used in the Plan shall also
include the opposite  gender;  and the  definition of any term in Section 2.1 in
the singular shall also include the plural, and vice versa.

                                    ARTICLE 3
                                 ADMINISTRATION

                  3.1 General. Except as provided in Section 3.7, the Plan shall
be administered by a Committee composed as described in Section 3.2.

                  3.2  Composition  of the  Committee.  The  Committee  shall be
appointed  by the  Board  from  among  its  members  in a number  and with  such
qualifications  as will  meet  the  requirements  for  approval  by a  committee
pursuant to Rule 16b-3 under the  Exchange  Act. The Board may from time to time
remove  members  from,  or add  members  to,  the  Committee.  Vacancies  on the
Committee,  however caused, shall be filled by the Board. The initial members of
the  Committee  shall  be  the  members  of  Corporation's   existing  Executive
Compensation  Committee.  The  Board  may  at any  time  replace  the  Executive
Compensation  Committee with another Committee.  In the event that the Executive
Compensation  Committee  shall cease to satisfy the  requirements of Rule 16b-3,
the Board shall appoint another Committee satisfying such requirements.

                  3.3 Authority of the Committee.  The Committee shall have full
power and authority  (subject to such orders or  resolutions as may be issued or
adopted  from  time to time by the  Board)  to  administer  the Plan in its sole
discretion, including the authority to:

                  (a)  Construe and interpret the Plan and any Award Agreement;

                  (b)  Promulgate,  amend,  and  rescind  rules  and  procedures
         relating to the implementation of the Plan;

                  (c) With respect to employees and Advisors:

                           (i) Select the  employees  and  Advisors who shall be
                  granted Awards;

                           (ii)  Determine  the number and types of Awards to be
                  granted to each such Participant;


                                      - 4 -
<PAGE>


                           (iii)  Determine  the  number  of  Shares,  or  Share
                  equivalents,  to be  subject  to each  Award and  whether  the
                  Shares subject to an Award are to be Agritope Shares,  Medical
                  Products Shares, or a combination of both;

                           (iv) Determine the option price, purchase price, base
                  price, or similar feature for any Award; and

                           (v)  Determine  all the terms and  conditions  of all
                  Award  Agreements,  consistent  with the  requirements  of the
                  Plan.

Decisions of the Committee,  or any delegate as permitted by the Plan,  shall be
final, conclusive, and binding on all Participants.

                  3.4 Action by the Committee.  A majority of the members of the
Committee  shall  constitute a quorum for the  transaction  of business.  Action
approved by a majority  of the members  present at any meeting at which a quorum
is present,  or action in writing by all the members of the Committee,  shall be
the valid acts of the Committee.

                  3.5 Delegation.  Notwithstanding the foregoing,  the Committee
may delegate to one or more officers of  Corporation  the authority to determine
the recipients,  types, amounts, and terms of Awards granted to Participants who
are not Reporting Persons.

                  3.6 Liability of Committee Members. No member of the Committee
shall be liable for any action or determination  made in good faith with respect
to the Plan, any Award, or any Participant.

                  3.7  Awards  to  Non-Employee  Directors.  The Board may grant
Awards  from time to time to  Non-Employee  Directors.  Awards  to  Non-Employee
Directors  shall be governed by and shall be subject to the terms and conditions
set forth in an Award Agreement in a form approved by the Board.

                  3.8 Costs of Plan. The costs and expenses of administering the
Plan shall be borne by Corporation.

                                    ARTICLE 4
               DURATION OF THE PLAN AND SHARES SUBJECT TO THE PLAN


                  4.1  Duration of the Plan.  The Plan is  effective  January 8,
1991,  subject to approval by Corporation's  shareholders as provided in Article
17. The Plan shall remain in effect until Awards have been granted  covering all
the  available  Shares  or the  Plan  is  otherwise  terminated  by  the  Board.
Termination of the Plan shall not affect outstanding Awards.

                  4.2  Shares Subject to the Plan.

                  4.2.1 General.  The shares which may be made subject to Awards
under the Plan shall be Shares of Common Stock,  which may be either  authorized
and unissued Shares or reacquired  Shares.  No fractional Shares shall be issued
under the Plan. If an Award under the Plan is canceled or expires for any reason
prior to having been fully Vested or exercised by a Participant or is settled in
cash in lieu of Shares or is exchanged for other Awards,  all Shares  covered by
such  Awards  shall  be  made  available  for  future  Awards  under  the  Plan.
Furthermore,  any Shares  used as full or partial  payment to  Corporation  by a
Participant of the option, purchase, or other exercise price of an Award and any
Shares covered by a Stock  Appreciation Right which are not issued upon exercise
shall become available for future Awards.

                  4.2.2 Medical Products  Shares.  The maximum number of Medical
Products  Shares  for  which  Awards  may be  granted  under  the Plan  shall be
3,400,000 Medical Products Shares, plus the number of Shares


                                      - 5 -
<PAGE>


which were available for grant under  Corporation's  Incentive Stock Option Plan
for Key Employees of Epitope,  Inc. (the "ISOP"), on January 8, 1991, subject to
adjustment pursuant to Article 14.

                  4.2.3 Agritope  Shares.  The maximum number of Agritope Shares
for which Awards may be granted under the Plan shall be (i)  1,000,000  Agritope
Shares plus (ii) that number of Agritope  Shares which is one-half of the number
of shares of Epitope  Common Stock  (rounded  down to the nearest  whole number)
subject to  outstanding  Options under the Plan on the Agritope  Stock  Proposal
Date, in each case subject to adjustment pursuant to Article 14.

                  4.2.4  Availability  of Shares for Future Awards.  If an Award
under the Plan or under the ISOP is canceled or expires for any reason  prior to
having been fully Vested or exercised by a Participant  or is settled in cash in
lieu of Shares or is  exchanged  for other  Awards,  all Shares  covered by such
Awards shall be made  available for future  Awards under the Plan.  Furthermore,
any Shares used as full or partial  payment to  Corporation  by a Participant of
the option, purchase, or other exercise price of an Award and any Shares covered
by a Stock  Appreciation  Right which are not issued upon exercise  shall become
available for future Awards.

                                    ARTICLE 5
                                   ELIGIBILITY

                  5.1 Employees  and Advisors.  Officers and other key employees
of Corporation and its Subsidiaries (who may also be directors of Corporation or
a Subsidiary)  and Advisors  who, in the  Committee's  judgment,  are or will be
contributors  to the  long-term  success of  Corporation  shall be  eligible  to
receive Awards under the Plan.

                  5.2 Non-Employee  Directors.  All Non-Employee Directors shall
be eligible to receive Awards as provided in Section 3.7 of the Plan.

                                    ARTICLE 6
                                     AWARDS

                  6.1 Types of Awards.  The types of Awards  that may be granted
under the Plan are:

                  (a)  Options governed by Article 7 of the Plan;

                  (b) Stock  Appreciation  Rights  governed  by Article 8 of the
         Plan;

                  (c)  Restricted Awards governed by Article 9 of the Plan;

                  (d) Performance Awards governed by Article 10 of the Plan; and

                  (e) Other Stock-Based Awards or combination awards governed by
         Article 11 of the Plan.

In the discretion of the Committee,  any Award may be granted alone, in addition
to, or in tandem with other Awards under the Plan.

                  6.2  General.  Subject  to the  limitations  of the Plan,  the
Committee may cause  Corporation to grant Awards to such  Participants,  at such
times,  of such  types,  in such  amounts,  for such  periods,  with such option
prices, purchase prices, or base prices, and subject to such terms,  conditions,
limitations,  and restrictions as the Committee,  in its discretion,  shall deem
appropriate.  Awards may be granted as additional  compensation to a Participant
or in lieu of other compensation to such Participant.  A Participant may receive
more than one Award and more than one type of Award under the Plan.


                                      - 6 -
<PAGE>


                  6.3 Nonuniform Determinations.  The Committee's determinations
under  the  Plan  or  under  one or more  Award  Agreements,  including  without
limitation,  (a) the selection of Participants to receive Awards,  (b) the type,
form,  amount, and timing of Awards, (c) the terms of specific Award Agreements,
and (d)  elections  and  determinations  made by the  Committee  with respect to
exercise  or  payments  of Awards,  need not be  uniform  and may be made by the
Committee selectively among Participants and Awards, whether or not Participants
are similarly situated.

                  6.4 Award  Agreements.  Each  Award  shall be  evidenced  by a
written  Award  Agreement  between   Corporation  and  the  Participant.   Award
Agreements  may,  subject to the  provisions of the Plan,  contain any provision
approved by the Committee.

                  6.5  Provisions  Governing  All  Awards.  All Awards  shall be
subject to the following provisions:

                  (a) Type of Shares. Each Award Agreement shall specify whether
         the  Award  covers  Agritope  Shares,  Medical  Products  Shares,  or a
         specified combination of both.

                  (b) Alternative  Awards. If any Awards are designated in their
         Award  Agreements as alternative to each other,  the exercise of all or
         part of one Award  automatically shall cause an immediate equal (or pro
         rata)  corresponding  termination  of the  other  alternative  Award or
         Awards.

                  (c)  Rights as  Shareholders.  No  Participant  shall have any
         rights of a  shareholder  with  respect  to Shares  subject to an Award
         until such Shares are issued in the name of the Participant.

                  (d)  Employment  Rights.  Neither the adoption of the Plan nor
         the  granting  of any Award  shall  confer on any  person  the right to
         continued employment with Corporation or any Subsidiary or the right to
         remain  as a  director  of  Corporation  or a  member  of any  Advisory
         Committee,  as the case may be, nor shall it  interfere in any way with
         the right of  Corporation  or a Subsidiary  to terminate  such person's
         employment  or to remove  such person as an Advisor or as a director at
         any time for any reason, with or without cause.

                  (e) Termination Of Employment.  The terms and conditions under
         which an  Award  may be  exercised,  if at all,  after a  Participant's
         termination of employment or service as an Advisor or as a Non-Employee
         Director  shall be  determined  by the  Committee  and specified in the
         applicable Award Agreement.

                  (f) Change in Control. The Committee,  in its discretion,  may
         provide in any Award Agreement that in the event of a change in control
         of  Corporation  (as the  Committee  may define  such term in the Award
         Agreement), as of the date of such change in control:

                           (i) All, or a specified  portion of, Awards requiring
                  exercise  shall  become  fully  and  immediately  exercisable,
                  notwithstanding any other limitations on exercise;

                           (ii) All, or a specified  portion of, Awards  subject
                  to Restrictions shall become fully Vested; and

                           (iii) All, or a specified  portion of, Awards subject
                  to  Performance  Goals  shall be  deemed  to have  been  fully
                  earned.

         The  Committee,  in its  discretion,  may  include  change  in  control
         provisions  in some Award  Agreements  and not in others,  may  include
         different change in control  provisions in different Award  Agreements,
         and may include  change in control  provisions  for some Awards or some
         Participants and not for others.

                  (g) Reporting  Persons.  With respect to all Awards granted to
         Reporting Persons, the Award Agreement shall provide that:


                                      - 7 -
<PAGE>


                           (i)   Awards   requiring   exercise   shall   not  be
                  exercisable until at least six months after the date the Award
                  was granted,  except in the case of the death or Disability of
                  the Participant; and

                           (ii)  Shares  issued  pursuant to any other Award may
                  not be sold by the  Participant  for at least six months after
                  acquisition,  except in the case of the death or Disability of
                  the Participant;

         provided,  however, that (unless an Award Agreement provides otherwise)
         the  limitation  of this  Section  6.5(g) shall apply only if or to the
         extent  required by Rule 16b-3 under the Exchange Act or any applicable
         successor  provision.  Award Agreements for Awards to Reporting Persons
         shall also  comply  with any future  restrictions  imposed by such Rule
         16b-3.

                  (h)  Service  Periods.  At the time of  granting  Awards,  the
         Committee may specify,  by resolution  or in the Award  Agreement,  the
         period or  periods  of  service  performed  or to be  performed  by the
         Participant in connection with the grant of the Award.

                                    ARTICLE 7
                                     OPTIONS

                  7.1 Types of Options. Options granted under the Plan may be in
the form of Incentive Stock Options or Nonqualified  Options (including Deferred
Compensation  Options).  The  grant  of  each  Option  and the  Award  Agreement
governing  each  Option  shall  identify  the Option as an ISO or an NQO. In the
event the Code is amended  to provide  for  tax-favored  forms of stock  options
other than or in addition to Incentive  Stock  Options,  the Committee may grant
Options under the Plan meeting the requirements of such forms of options.

                  7.2  General.  Options  shall  be  subject  to the  terms  and
conditions  set forth in  Article 6 and this  Article 7 and shall  contain  such
additional terms and conditions, not inconsistent with the express provisions of
the Plan, as the Committee (or the Board with respect to Awards to  Non-Employee
Directors) shall deem desirable.

                  7.3 Option Price. Each Award Agreement for Options shall state
the  option  exercise  price  per Share of Common  Stock  purchasable  under the
Option, which shall not be less than:

                  (a) $1  per  share  in the  case  of a  Deferred  Compensation
         Option;

                  (b) 75 percent of the Fair Market Value of a Share on the date
         of grant for all other Nonqualified Options; or

                  (c) 100  percent  of the Fair  Market  Value of a Share on the
         date of grant for all Incentive Stock Options.

                  7.4 Option  Term.  The Award  Agreement  for each Option shall
specify the term of each Option,  which may be unlimited or may have a specified
period during which the Option may be exercised, as determined by the Committee.

                  7.5 Time of  Exercise.  The Award  Agreement  for each  Option
shall specify, as determined by the Committee:

                  (a) The time or times when the Option shall become exercisable
         and whether the Option shall become exercisable in full or in graduated
         amounts over a period specified in the Award Agreement;

                  (b) Such other terms, conditions,  and restrictions as to when
         the Option may be exercised as shall be  determined  by the  Committee;
         and


                                      - 8 -
<PAGE>


                  (c) The  extent,  if any,  to which the  Option  shall  remain
         exercisable after the Participant ceases to be an employee, Advisor, or
         director of Corporation or a Subsidiary.

An Award  Agreement  for an Option  may,  in the  discretion  of the  Committee,
provide  whether,  and to what extent,  the Option will become  immediately  and
fully  exercisable (i) in the event of the death,  Disability,  or Retirement of
the  Participant,  or (ii)  upon  the  occurrence  of a  change  in  control  of
Corporation.

                  7.6 Method of Exercise.  The Award  Agreement  for each Option
shall  specify the method or methods of payment  acceptable  upon exercise of an
Option.  An Award Agreement may provide that the option price is payable in full
in cash or, at the discretion of the Committee:

                  (a) In  installments on such terms and over such period as the
         Committee shall determine;

                  (b)  In  previously  acquired  Shares  (including   Restricted
         Shares);

                  (c)  By  surrendering   outstanding   Awards  under  the  Plan
         denominated in Shares or in Share-equivalent units;

                  (d) By delivery (in a form  approved by the  Committee)  of an
         irrevocable   direction  to  a  securities  broker  acceptable  to  the
         Committee:

                           (i) To  sell  Shares  subject  to the  Option  and to
                  deliver all or a part of the sales  proceeds to Corporation in
                  payment of all or a part of the option  price and  withholding
                  taxes due; or

                           (ii) To pledge  Shares  subject  to the Option to the
                  broker as security  for a loan and to deliver all or a part of
                  the loan proceeds to  Corporation  in payment of all or a part
                  of the option price and withholding taxes due; or

                  (e) In any  combination  of the foregoing or in any other form
         approved by the Committee.

If Restricted  Shares are  surrendered  in full or partial  payment of an Option
price, a  corresponding  number of the Shares issued upon exercise of the Option
shall be Restricted  Shares subject to the same  Restrictions as the surrendered
Restricted Shares.

                  7.7 Special Rules for Incentive Stock Options.  In the case of
an Option  designated as an Incentive Stock Option,  the terms of the Option and
the Award  Agreement  shall be in conformance  with the statutory and regulatory
requirements specified in Section 422 of the Code, as in effect on the date such
ISO is  granted.  ISOs may be granted  only to  employees  of  Corporation  or a
Subsidiary. ISOs may not be granted under the Plan after January 8, 2001, unless
the ten-year limitation of Section 422(b)(2) of the Code is removed or extended.

                  7.8 Restricted Shares. In the discretion of the Committee, the
Shares  issuable  upon  exercise  of an Option  may be  Restricted  Shares if so
provided in the Award Agreement.

                  7.9 Deferred  Compensation  Options. The Committee may, in its
discretion,  grant Deferred  Compensation Options with an option price less than
Fair  Market  Value to provide a means for  deferral of  compensation  to future
dates. The option price shall be determined by the Committee  subject to Section
7.3(a) of the Plan.  The number of Shares  subject  to a  Deferred  Compensation
Option shall be determined by the Committee, in its discretion,  by dividing the
amount of compensation to be deferred by the difference  between the Fair Market
Value  of a Share  on the date of grant  and the  option  price of the  Deferred
Compensation Option. Amounts of compensation deferred with Deferred Compensation
Options may include  amounts earned under Awards granted under the Plan or under
any other compensation program or arrangement of Corporation as permitted by the
Committee. The Committee shall grant Deferred Compensation Options only if it


                                      - 9 -
<PAGE>


reasonably  determines  that the recipient of such an Option is not likely to be
deemed to be in constructive receipt for income tax purposes of the income being
deferred.

                  7.10 Reload Options.  The Committee,  in its  discretion,  may
provide in an Award  Agreement  for an Option that in the event all or a portion
of the Option is exercised by the Participant using previously  acquired Shares,
the Participant  shall  automatically  be granted a replacement  Option (with an
option  price  equal  to the  Fair  Market  Value of a Share on the date of such
exercise)  for a number of Shares equal to (or equal to a portion of) the number
of shares  surrendered upon exercise of the Option.  Such reload Option features
may be subject to such terms and  conditions as the Committee  shall  determine,
including without limitation, a condition that the Participant retain the Shares
issued upon exercise of the Option for a specified period of time.

                  7.11 Limitation on Number of Shares Subject to Options.  In no
event may  options  for more than  500,000  Shares be granted to any  individual
under the Plan during any fiscal year period.

                                    ARTICLE 8
                            STOCK APPRECIATION RIGHTS

                  8.1 General. Stock Appreciation Rights shall be subject to the
terms and conditions set forth in Article 6 and this Article 8 and shall contain
such additional terms and conditions, not inconsistent with the express terms of
the Plan, as the Committee (or the Board with respect to Awards to  Non-Employee
Directors) shall deem desirable.

                  8.2 Nature of Stock  Appreciation  Right. A Stock Appreciation
Right is an Award  entitling  a  Participant  to receive an amount  equal to the
excess (or if the Committee  shall  determine at the time of grant, a portion of
the excess) of the Fair Market  Value of a Share of Common  Stock on the date of
exercise  of the SAR over the base price,  as  described  below,  on the date of
grant of the SAR,  multiplied  by the number of Shares with respect to which the
SAR  shall  have been  exercised.  The base  price  shall be  designated  by the
Committee in the Award Agreement for the SAR and may be the Fair Market Value of
a Share on the grant date of the SAR or such other  higher or lower price as the
Committee shall determine.

                  8.3 Exercise. A Stock Appreciation Right may be exercised by a
Participant in accordance  with  procedures  established  by the Committee.  The
Committee may also provide that a SAR shall be automatically exercised on one or
more  specified  dates  or  upon  the  satisfaction  of  one or  more  specified
conditions.  In the case of SARs granted to Reporting  Persons,  exercise of the
SAR shall be limited by the Committee to the extent  required to comply with the
applicable requirements of Rule 16b-3 under the Exchange Act.

                  8.4  Form  of  Payment.  Payment  upon  exercise  of  a  Stock
Appreciation Right may be made in cash, in installments,  in Shares, by issuance
of a Deferred Compensation Option, or in any combination of the foregoing, or in
any other form as the Committee shall determine.

                                    ARTICLE 9
                                RESTRICTED AWARDS

                  9.1 Types of  Restricted  Awards.  Restricted  Awards  granted
under the Plan may be in the form of  either  Restricted  Shares  or  Restricted
Units.

                  (a)  Restricted  Shares.  A  Restricted  Share  is an Award of
         Shares  transferred  to  a  Participant   subject  to  such  terms  and
         conditions  as the  Committee  deems  appropriate,  including,  without
         limitation,  restrictions on the sale,  assignment,  transfer, or other
         disposition  of such  Restricted  Shares and may include a  requirement
         that the Participant forfeit such Restricted Shares back to Corporation
         upon termination of Participant's employment (or service as an Advisor)
         for specified  reasons within a specified  period of time or upon other
         conditions,  as set forth in the Award  Agreement  for such  Restricted
         Shares. Each Participant receiving a Restricted Share shall be issued a
         stock certificate in


                                     - 10 -
<PAGE>


         respect of such Shares, registered in the name of such Participant, and
         shall  execute  a stock  power  in blank  with  respect  to the  Shares
         evidenced  by  such  certificate.   The  certificate   evidencing  such
         Restricted  Shares  and the stock  power  shall be held in  custody  by
         Corporation until the Restrictions thereon shall have lapsed.

                  (b) Restricted  Units. A Restricted  Unit is an Award of units
         (with each unit having a value  equivalent  to one Share)  granted to a
         Participant subject to such terms and conditions as the Committee deems
         appropriate, and may include a requirement that the Participant forfeit
         such Restricted Units upon termination of Participant's  employment (or
         service as an Advisor) for specified  reasons within a specified period
         of time or upon other  conditions,  as set forth in the Award Agreement
         for such Restricted Units.

                  9.2 General.  Restricted  Awards shall be subject to the terms
and conditions of Article 6 and this Article 9 and shall contain such additional
terms and conditions,  not inconsistent with the express provisions of the Plan,
as the Committee (or the Board with respect to Awards to Non-Employee Directors)
shall deem desirable.

                  9.3 Restriction  Period.  Restricted Awards shall provide that
such Awards, and the Shares subject to such Awards, may not be transferred,  and
may  provide  that,  in order  for a  Participant  to Vest in such  Awards,  the
Participant  must  remain  in  the  employment  (or  remain  as an  Advisor)  of
Corporation or its Subsidiaries,  subject to relief for reasons specified in the
Award Agreement,  for a period commencing on the date of the Award and ending on
such later date or dates as the Committee may designate at the time of the Award
(the "Restriction Period"). During the Restriction Period, a Participant may not
sell,  assign,  transfer,  pledge,  encumber,  or  otherwise  dispose  of Shares
received under or governed by a Restricted  Award grant.  The Committee,  in its
sole  discretion,  may provide  for the lapse of  restrictions  in  installments
during the Restriction  Period.  Upon  expiration of the applicable  Restriction
Period  (or  lapse of  Restrictions  during  the  Restriction  Period  where the
Restrictions  lapse  in  installments)  the  Participant  shall be  entitled  to
settlement  of the  Restricted  Award or  portion  thereof,  as the case may be.
Although Restricted Awards shall usually Vest based on continued  employment (or
service as an Advisor) and  Performance  Awards under  Article 10 shall  usually
Vest based on attainment of Performance Goals, the Committee, in its discretion,
may condition Vesting of Restricted Awards on attainment of Performance Goals as
well as  continued  employment  (or service as an  Advisor).  In such case,  the
Restriction Period for such a Restricted Award shall include the period prior to
satisfaction of the Performance Goals.

                  9.4 Forfeiture.  If a Participant  ceases to be an employee or
Advisor of Corporation  or a Subsidiary  during the  Restriction  Period for any
reason other than reasons which may be specified in an Award  Agreement (such as
death,  Disability,  or  Retirement)  the Award  Agreement  may require that all
non-Vested  Restricted Awards previously granted to the Participant be forfeited
and returned to Corporation.

                  9.5  Settlement of Restricted Awards.

                  (a)  Restricted  Shares.  Upon Vesting of a  Restricted  Share
Award,  the legend on such Shares will be removed  and the  Participant's  stock
power will be returned and the Shares will no longer be Restricted  Shares.  The
Committee may also, in its discretion,  permit a Participant to receive, in lieu
of unrestricted Shares at the conclusion of the Restriction  Period,  payment in
cash,  installments,  or by issuance of a Deferred  Compensation Option equal to
the Fair Market Value of the Restricted  Shares as of the date the  Restrictions
lapse.

                  (b) Restricted Units. Upon Vesting of a Restricted Unit Award,
a Participant  shall be entitled to receive  payment for Restricted  Units in an
amount equal to the  aggregate  Fair Market Value of the Shares  covered by such
Restricted Units at the expiration of the Applicable Restriction Period. Payment
in  settlement  of a  Restricted  Unit  shall  be made  as  soon as  practicable
following  the  conclusion  of the  applicable  Restriction  Period in cash,  in
installments,  in Shares equal to the number of Restricted Units, by issuance of
a Deferred  Compensation  Option,  or in any other manner or combination of such
methods as the Committee, in its sole discretion, shall determine.


                                     - 11 -
<PAGE>


                  9.6 Rights as a Shareholder.  A Participant  shall have,  with
respect to unforfeited  Shares received under a grant of Restricted  Shares, all
the rights of a  shareholder  of  Corporation,  including  the right to vote the
shares, and the right to receive any cash dividends. Stock dividends issued with
respect to Restricted  Shares shall be treated as additional  Shares  covered by
the grant of Restricted Shares and shall be subject to the same Restrictions.

                                   ARTICLE 10
                               PERFORMANCE AWARDS

                  10.1 General. Performance Awards shall be subject to the terms
and conditions set forth in Article 6 and this Article 10 and shall contain such
other terms and conditions not inconsistent  with the express  provisions of the
Plan,  as the  Committee  (or the Board with  respect to Awards to  Non-Employee
Directors) shall deem desirable.

                  10.2 Nature of Performance  Awards. A Performance  Award is an
Award of units (with each unit having a value  equivalent to one Share)  granted
to a Participant  subject to such terms and  conditions  as the Committee  deems
appropriate, including, without limitation, the requirement that the Participant
forfeit  such  Performance  Award or a portion  thereof  in the event  specified
performance criteria are not met within a designated period of time.

                  10.3  Performance  Cycles.  For each  Performance  Award,  the
Committee shall designate a performance period (the "Performance  Cycle") with a
duration to be  determined  by the  Committee  in its  discretion  within  which
specified Performance Goals are to be attained. There may be several Performance
Cycles in existence at any one time and the duration of  Performance  Cycles may
differ from each other.

                  10.4   Performance   Goals.   The  Committee  shall  establish
Performance  Goals for each Performance  Cycle on the basis of such criteria and
to  accomplish  such  objectives  as the Committee may from time to time select.
Performance  Goals  may be based on  performance  criteria  for  Corporation,  a
Subsidiary,  or an  operating  group,  or  based on a  Participant's  individual
performance.  Performance Goals may include  objective and subjective  criteria.
During any Performance Cycle, the Committee may adjust the Performance Goals for
such  Performance  Cycle as it deems  equitable  in  recognition  of  unusual or
nonrecurring  events  affecting  Corporation,  changes in applicable tax laws or
accounting principles, or such other factors as the Committee may determine.

                  10.5 Determination of Awards. As soon as practicable after the
end of a Performance  Cycle,  the Committee  shall determine the extent to which
Performance  Awards have been earned on the basis of  performance in relation to
the established Performance Goals.

                  10.6  Timing  and  Form  of  Payment.   Settlement  of  earned
Performance Awards shall be made to the Participant as soon as practicable after
the expiration of the Performance Cycle and the Committee's  determination under
Section 10.5, in the form of cash,  installments,  Shares, Deferred Compensation
Options,  or any  combination  of the  foregoing  or in any  other  form  as the
Committee shall determine.

                                   ARTICLE 11
                    OTHER STOCK-BASED AND COMBINATION AWARDS

                  11.1 Other  Stock-Based  Awards.  The  Committee (or the Board
with respect to Awards to  Non-Employee  Directors) may grant other Awards under
the Plan  pursuant  to which  Shares  are or may in the future be  acquired,  or
Awards  denominated in or measured by Share equivalent  units,  including Awards
valued  using  measures  other  than the  market  value of  Shares.  Such  Other
Stock-Based  Awards may be granted  either  alone,  in addition to, or in tandem
with, any other type of Award granted under the Plan.

                  11.2 Combination  Awards.  The Committee may also grant Awards
under the Plan in tandem or  combination  with other  Awards or in  exchange  of
Awards, or in tandem or combination with, or as


                                     - 12 -
<PAGE>


alternatives  to, grants or rights under any other employee plan of Corporation,
including the plan of any acquired entity.  No action authorized by this section
shall  reduce  the  amount of any  existing  benefits  or  change  the terms and
conditions thereof without the Participant's consent.

                                   ARTICLE 12
                               DEFERRAL ELECTIONS

                  The  Committee  may  permit  a  Participant  to elect to defer
receipt of the payment of cash or the delivery of Shares that would otherwise be
due to such  Participant by virtue of the exercise,  earn-out,  or Vesting of an
Award made under the Plan.  If any such  election is  permitted,  the  Committee
shall establish rules and procedures for such payment deferrals,  including, but
not limited to: (a) payment or crediting of reasonable interest on such deferred
amounts  credited in cash, (b) the payment or crediting of dividend  equivalents
in respect of deferrals  credited in Share equivalent  units, or (c) granting of
Deferred Compensation Options.

                                   ARTICLE 13
                              DIVIDEND EQUIVALENTS

                  Any Awards  may,  at the  discretion  of the  Committee,  earn
dividend  equivalents.  In respect of any such Award which is  outstanding  on a
dividend  record date for Common Stock,  the Participant may be credited with an
amount equal to the amount of cash or stock  dividends that would have been paid
on the Shares  covered by such Award,  had such  covered  Shares been issued and
outstanding  on such dividend  record date. The Committee  shall  establish such
rules and procedures governing the crediting of dividend equivalents,  including
the  timing,  form of  payment,  and  payment  contingencies  of  such  dividend
equivalents, as it deems are appropriate or necessary.

                                   ARTICLE 14
                ADJUSTMENTS UPON CHANGES IN CAPITALIZATION, ETC.

                  14.1 Plan Does Not Restrict Corporation.  The existence of the
Plan and the Awards  granted  hereunder  shall not affect or restrict in any way
the right or power of the Board or the  shareholders  of  Corporation to make or
authorize any adjustment,  recapitalization,  reorganization, or other change in
Corporation's capital structure or its business,  any merger or consolidation of
the Corporation,  any issue of bonds, debentures,  preferred or prior preference
stocks ahead of or affecting  Corporation's capital stock or the rights thereof,
the  dissolution or liquidation of Corporation or any sale or transfer of all or
any part of its assets or business, or any other corporate act or proceeding.

                  14.2 Adjustments by the Committee.  In the event of any change
in  capitalization  affecting the Common Stock of  Corporation,  such as a stock
dividend,  stock  split,  recapitalization,   merger,  consolidation,  split-up,
combination or exchange of shares or other form of reorganization,  or any other
change affecting the Common Stock, such  proportionate  adjustments,  if any, as
the  Committee,  in its sole  discretion,  may deem  appropriate to reflect such
change,  shall be made with respect to the aggregate  number of Shares for which
Awards in respect  thereof may be granted under the Plan,  the maximum number of
Shares  which may be sold or  awarded to any  Participant,  the number of Shares
covered  by each  outstanding  Award,  and the  price per  Share in  respect  of
outstanding  Awards.  The Committee may also make such adjustments in the number
of Shares covered by, and price or other value of any outstanding  Awards in the
event of a spin-off or other distribution (other than normal cash dividends), of
Corporation assets to shareholders.

                                   ARTICLE 15
                            AMENDMENT AND TERMINATION

                  Without further  approval of Corporation's  shareholders,  the
Board may at any time  terminate  the Plan, or may amend it from time to time in
such  respects as the Board may deem  advisable,  except that the Board may not,
without approval of the  shareholders,  make any amendment that would materially
increase the


                                     - 13 -
<PAGE>


aggregate  number of shares of Common  Stock  that may be issued  under the Plan
(except for  adjustments  pursuant to Article 14 of the Plan).  Without  further
shareholder approval,  the Board may amend the Plan to take into account changes
in applicable  securities,  federal income tax laws, and other  applicable laws.
Further,  should the provisions of Rule 16b-3, or any successor rule,  under the
Exchange Act be amended,  the Board, without further shareholder  approval,  may
amend the Plan as necessary to comply with any modifications to such rule.

                                   ARTICLE 16
                                  MISCELLANEOUS

                  16.1  Tax Withholding.

                  16.1.1  General.  Corporation  shall  have the right to deduct
from any settlement, including the delivery or vesting of Shares, made under the
Plan any  federal,  state,  or local  taxes  of any kind  required  by law to be
withheld  with  respect to such  payments or to take such other action as may be
necessary  in the  opinion of  Corporation  to satisfy all  obligations  for the
payment of such taxes.  The recipient of any payment or  distribution  under the
Plan shall make arrangements satisfactory to Corporation for the satisfaction of
any such withholding tax obligations.  Corporation shall not be required to make
any such  payment or  distribution  under the Plan until  such  obligations  are
satisfied.

                  16.1.2  Stock   Withholding.   The  Committee,   in  its  sole
discretion, may permit a Participant to satisfy all or a part of the withholding
tax  obligations  incident to the  settlement of an Award  involving  payment or
delivery of Shares to the Participant by having  Corporation  withhold a portion
of the Shares that would otherwise be issuable to the  Participant.  Such Shares
shall be valued based on their Fair Market Value on the date the tax withholding
is required to be made. Any stock withholding with respect to a Reporting Person
shall be subject to such  limitations as the Committee may impose to comply with
the requirements of the Exchange Act.

                  16.2 Unfunded Plan. The Plan shall be unfunded and Corporation
shall  not be  required  to  segregate  any  assets  that  may at  any  time  be
represented by Awards under the Plan. Any liability of Corporation to any person
with  respect  to any  Award  under  the Plan  shall be  based  solely  upon any
contractual  obligations  that may be  effected  pursuant  to the Plan.  No such
obligation  of  Corporation  shall be deemed to be  secured by any pledge of, or
other encumbrance on, any property of Corporation.

                  16.3  Payments to Trust.  The Committee is authorized to cause
to be established a trust agreement or several trust  agreements  whereunder the
Committee may make payments of amounts due or to become due to  Participants  in
the Plan.

                  16.4 Annulment of Awards. Any Award Agreement may provide that
the  grant of an Award  payable  in cash is  provisional  until  cash is paid in
settlement  thereof or that grant of an Award  payable in Shares is  provisional
until the Participant becomes entitled to the certificate in settlement thereof.
In the event the  employment  (or  service as an Advisor  or  membership  on the
Board) of a Participant  is terminated for cause (as defined  below),  any Award
which is provisional  shall be annulled as of the date of such  termination  for
cause. For the purpose of this Section 16.4, the term "for cause" shall have the
meaning  set  forth  in the  Participant's  employment  agreement,  if  any,  or
otherwise means any discharge (or removal) for material or flagrant violation of
the policies and  procedures  of  Corporation  or for other job  performance  or
conduct which is materially detrimental to the best interests of Corporation, as
determined by the Committee.

                  16.5  Engaging  in  Competition  With  Corporation.  Any Award
Agreement  may  provide  that,  if  a  Participant  terminates  employment  with
Corporation  or a  Subsidiary  for any reason  whatsoever,  and within 18 months
after the date thereof  accepts  employment with any competitor of (or otherwise
engages in competition with) Corporation, the Committee, in its sole discretion,
may require such  Participant to return to Corporation the economic value of any
Award that is realized or obtained  (measured at the date of exercise,  Vesting,
or


                                     - 14 -
<PAGE>


payment) by such Participant at any time during the period beginning on the date
that is six  months  prior  to the  date of such  Participant's  termination  of
employment with Corporation.

                  16.6 Other  Corporation  Benefit  and  Compensation  Programs.
Payments  and other  benefits  received  by a  Participant  under an Award  made
pursuant  to the Plan  shall  not be deemed a part of a  Participant's  regular,
recurring  compensation  for purposes of the termination  indemnity or severance
pay law of any state or country and shall not be included in, or have any effect
on, the  determination  of benefits  under any other  employee  benefit  plan or
similar arrangement  provided by Corporation or a Subsidiary unless expressly so
provided  by such  other plan or  arrangements,  or except  where the  Committee
expressly  determines that an Award or portion of an Award should be included to
accurately reflect  competitive  compensation  practices or to recognize that an
Award has been made in lieu of a portion of cash compensation.  Awards under the
Plan may be made in combination  with or in tandem with, or as alternatives  to,
grants,  awards,  or payments under any other  Corporation or Subsidiary  plans,
arrangements,  or  programs.  The  Plan  notwithstanding,   Corporation  or  any
Subsidiary   may  adopt  such  other   compensation   programs  and   additional
compensation  arrangements as it deems necessary to attract,  retain, and reward
employees and directors for their service with Corporation and its Subsidiaries.

                  16.7  Securities Law  Restrictions.  No Shares shall be issued
under the Plan  unless  counsel for  Corporation  shall be  satisfied  that such
issuance  will be in compliance  with  applicable  federal and state  securities
laws.  Certificates  for Shares  delivered under the Plan may be subject to such
stop-transfer  orders and other restrictions as the Committee may deem advisable
under the rules,  regulations,  and other  requirements  of the  Securities  and
Exchange  Commission,  any stock  exchange  upon which the Common  Stock is then
listed,  and any applicable  federal or state  securities law. The Committee may
cause a legend or legends to be put on any such certificates to make appropriate
reference to such restrictions.

                  16.8 Governing  Law.  Except with respect to references to the
Code or federal securities laws, the Plan and all actions taken thereunder shall
be governed by and construed in accordance with the laws of the state of Oregon.

                                   ARTICLE 17
                              SHAREHOLDER APPROVAL

                  The amendment and restatement of the Plan is expressly subject
to the approval of the Plan by the  shareholders  at the 1997 annual  meeting of
Corporation's shareholders.


                                     - 15 -

                                 AWARD AGREEMENT
                                    UNDER THE
                                 AGRITOPE, INC.,
                              1992 STOCK AWARD PLAN

                       NONQUALIFIED STOCK OPTION AGREEMENT

                               Dated July 26, 1997

Agritope, Inc.
8505 S.W. Creekside Place
Beaverton, Oregon 97008                                          ("Corporation")

- -----------------                                                ("Participant")
- -----------------
- -----------------

                                    RECITALS

                  A.  Participant  is an  employee of  Corporation.  Corporation
desires to have  Participant  remain in his or her capacity with  Corporation or
Epitope,  and to afford Participant the opportunity to obtain stock ownership in
Corporation so that Participant may have a significant  proprietary  interest in
Corporation's success.

                  B. The board of directors  of  Corporation  (the  "Board") has
granted to Participant a  nonqualified  stock option  pursuant to  Corporation's
1992 Stock Award Plan (the "Plan"),  subject to the terms and conditions of this
Agreement.

                  C. Capitalized  terms not otherwise  defined have the meanings
given in Section 11.
                                    AGREEMENT

                  In  consideration  of services  rendered and to be rendered by
Participant  to Corporation  and of the agreements set forth below,  the parties
agree as follows:

                  1. Grant of Option.  Subject  to the terms and  conditions  of
this  Agreement,  Corporation  grants  to  Participant,  as of the  date of this
Agreement (the  "Effective  Date"),  an option (the "Option") to purchase ------
shares ("Shares") of Corporation's common stock, no par value (the "Stock").

                  2.  Terms of Option.

                  2.1  Price.  The  Option  price per share  shall be $2.98 (the
"Option  Price").  If any reduction (the "Epitope Option  Reduction") is made to
the exercise prices of options  outstanding  under the Epitope,  Inc. 1991 Stock
Award Plan in


                                      - 1 -
<PAGE>


connection with the Spin-Off, as defined below, the Option price hereunder shall
be reduced by an amount equal to the product of the Epitope Option Reduction and
a factor of .411, without further action of the Corporation.

                  2.2 Term. The term of the Option shall be unlimited; provided,
however, that to the extent not previously exercised, the Option shall terminate
upon the earlier of the following dates:

                  (a)  One  year  after  Participant  ceases  to be a  director,
         officer,  or  employee of  Corporation,  Epitope,  or their  respective
         Subsidiaries  (including  with respect to periods  after the  effective
         date of the  Spin-Off  described  in Section  2.4) for any reason other
         than Participant's Retirement; or

                  (b) Five  years  after  Participant  ceases to be a  director,
         officer,  or  employee of  Corporation,  Epitope,  or their  respective
         Subsidiaries as a result of Participant's Retirement.

                  2.3 Time of  Exercise.  Unless  the  Option is  terminated  as
provided in Section 2.2, the Option shall vest and  accordingly may be exercised
from  time  to  time to  purchase  a  cumulative  total  of up to the  following
percentage of the Shares:

                  [For each Replacement Option, the exercisability schedule will
be the same as the replaced Out-of-the-Money Option.]

                  2.4 Effect of Spin-Off.  In the event the stock of Corporation
is distributed by Epitope to its shareholders in a spin-off  transaction or sale
or other  disposition as a result of which the Corporation is no longer a wholly
owned  subsidiary of Epitope (a  "Spin-Off"),  unless  Participant is, after the
effective  date of the  Spin-Off,  an employee  of  Epitope,  the Option will be
exercisable  only to the extent the Option had become  exercisable  pursuant  to
Section 2.3 as of the 90th day after the  effective  date of the  Spin-Off.  (If
Participant is an Epitope employee after the effective date of the Spin-Off, the
Option  will  continue to vest  pursuant  to Section 2.3 so long as  Participant
remains an employee of Epitope or its Subsidiaries and for 90 days thereafter.)

                  2.5  Acceleration  of  Exercisability.   Notwithstanding   the
provisions  of Sections 2.2 and 2.3, the  exercisability  of the Option shall be
accelerated upon a Change in Control Date occurring after the Registration Date.
Upon such a Change in Control  Date,  the Option  shall become  immediately  and
fully exercisable as to all Shares covered by the Option.

                  2.6 Method of Exercise; Payment. The Option shall be exercised
by  delivery  of  a  written  notice  to  Corporation,  signed  by  Participant,
specifying the


                                      - 2 -
<PAGE>


number of Shares that Participant then desires to purchase,  together with cash,
certified  check,  or bank draft payable to the order of  Corporation,  or other
form of  payment  acceptable  to  Corporation,  for an amount  of United  States
dollars equal to the aggregate Option Price of such Shares.  If Corporation,  in
its sole  discretion,  elects to allow payment of all or a portion of the Option
Price in installments, Participant shall also deliver a promissory note, in form
satisfactory  to  Corporation,  for the  deferred  portion of the  Option  Price
secured by a pledge, also in form satisfactory to Corporation,  of the Shares of
Stock  purchased  by such  exercise of the Option.  Following  any  Spin-off the
notice of exercise and the exercise  price shall be delivered  to, and any check
or bank draft shall be made payable to,  Epitope unless  otherwise  requested by
Corporation by notice to Participant.

                  2.7 Stock  Certificates.  Promptly after any exercise in whole
or  in  part  of  the  Option  by  Participant,  Corporation  shall  deliver  to
Participant a certificate or certificates, registered in Participant's name, for
the number of shares of Stock for which the Option was so exercised.

                  3. Nontransferability.

                  3.1 Restriction.

                  (a) The Option is not  transferable by Participant  other than
         by  testamentary  will or the laws of  descent  and  distribution  and,
         during Participant's  lifetime, may be exercised only by Participant or
         Participant's guardian or legal representative;

                  (b)  No  assignment   or  transfer  of  the  Option,   whether
         voluntary,  involuntary, or by operation of law or otherwise, except by
         testamentary will or the laws of descent and  distribution,  shall vest
         in the assignee or transferee any interest or right; and

                  (c)  Immediately  upon any attempt to assign or  transfer  the
         Option, the Option shall terminate and be of no force or effect.

                  3.2 Exercise in the Event of Death or Disability. Whenever the
word   "Participant"   is  used  in  any  provision  of  this  Agreement   under
circumstances  when the  provision  should  logically  be  construed to apply to
Participant's guardian, legal representative,  executor,  administrator,  or the
person or persons to whom the Option may be transferred by testamentary  will or
by the laws of descent and distribution,  the word "Participant" shall be deemed
to include such person or persons.

                  4. No Rights as  Shareholder  Prior to  Exercise.  Participant
shall not be deemed for any  purpose to be a  shareholder  of  Corporation  with
respect to any


                                      - 3 -
<PAGE>


shares  subject to the Option under this  Agreement as to which the Option shall
not have been exercised.

                  5.  Adjustments.

                  5.1 No Effect on Changes in Corporation's  Capital  Structure.
The  existence  of the Option  shall not affect in any way the right or power of
Corporation  or its  shareholders  to make  or  authorize  (a) any  adjustments,
recapitalizations,  reorganization,  or other changes in  Corporation's  capital
structure or its business,  (b) any merger or consolidation of Corporation,  (c)
any issue of bonds,  debentures,  preferred,  or  preference  stocks ahead of or
affecting the Shares, (d) the dissolution or liquidation of Corporation, (e) any
sale or transfer of all or any part of its assets or business,  or (f) any other
corporate act or proceeding, whether of a similar character or otherwise.

                  5.2  Adjustment to Option  Shares.  The Shares  subject to the
Option are Stock as constituted on the date of this Agreement,  but in the event
of any stock split or payment of a dividend on Stock payable in shares of Stock,
the  Shares  of  Stock  then   subject   to  the  Option   shall  be   increased
proportionately  without any change in the aggregate  Option  Price.  If all the
outstanding  shares of Stock shall be changed into or exchanged  for a different
number or class of shares of  Corporation,  or of another  corporation,  through
reorganization, recapitalization, stock split-up, combination of shares, merger,
consolidation,  or otherwise,  then there shall be substituted for each share of
Stock then  subject to the Option the number and class of shares into which each
outstanding share of Stock shall be so exchanged,  all without any change in the
aggregate Option Price for the shares then subject to the Option.  In connection
with any  adjustment  under this Section 5.2  resulting  in a  fractional  share
interest,  such interest  shall,  if less than 0.5 share, be rounded down to the
nearest whole share,  and otherwise be rounded up to the nearest whole share. No
adjustment  shall be made under this Section in connection with any stock split,
stock  dividend,  or other  event  described  in this  Section  that  occurs  in
connection  with a Spin-Off.  In case of any  adjustment  under this Section,  a
corresponding  adjustment  shall be made to the  Exchange  Ratio,  as defined in
Section 9.1.

                  6.  Compliance with Securities Laws.

                  6.1 No Exercise Until  Compliance.  If Corporation at any time
determines that  registration or qualification of the Shares,  the Stock, or the
Option  under  state  or  federal  law,  or  the  consent  or  approval  of  any
governmental regulatory body, is necessary or desirable, then the Option may not
be  exercised,  in whole or in part,  until  such  registration,  qualification,
consent, or approval shall have been effected or obtained free of any conditions
not acceptable to Corporation.


                                      - 4 -
<PAGE>


                  6.2  Investment  Interest.  If required by  Corporation at the
time of any exercise of the Option, as a condition to such exercise, Participant
shall enter into an agreement with  Corporation in form  satisfactory to counsel
for  Corporation by which  Participant  (a) shall  represent that the Shares are
being acquired for  Participant's own account for investment and not with a view
to, or for sale in connection  with, any resale or  distribution of such Shares,
and (b) shall agree that, if  Participant  should decide to sell,  transfer,  or
otherwise  dispose  of any of  such  Shares,  Participant  may do so only if the
Shares are registered  under the  Securities  Act of 1933 and  applicable  state
securities  laws,  unless,  in the  opinion of  counsel  for  Corporation,  such
registration is not required.

                  7.  Termination for Cause: Competition.

                  7.1 The grant of the  Option  governed  by this  Agreement  is
provisional  until  Participant  becomes entitled to a certificate for Shares in
settlement  thereof.  In the event  Participant's  employment  or  service  as a
director is terminated for cause (as defined  below),  any portion of the Option
that is  provisional  shall be annulled as of the date of such  termination  for
cause.  For the purpose of this Section 7.1, the term "for cause" shall have the
meaning set forth in Participant's  employment  agreement,  if any, or otherwise
means any discharge (or removal) for material or flagrant violation of corporate
policies  and  procedures  or for  other  job  performance  or  conduct  that is
materially  detrimental to the best interests of the employer,  as determined by
its board of directors.

                  7.2 If  Participant  ceases to be a director  or  employee  of
Corporation,   Epitope,  or  their  respective  Subsidiaries,   for  any  reason
whatsoever,  and within 18 months after the date thereof accepts employment with
any  competitor of (or otherwise  engages in  competition  with) the employer or
corporation of which Participant was a director, its board of directors,  in its
sole discretion,  may require  Participant to return to Corporation the economic
value of this  Option that is  realized  or  obtained  (measured  at the date of
exercise,  vesting,  or  payment) by  Participant  at any time during the period
beginning  on the date  that is six  months  prior to the date of  Participant's
termination of employment with or service as a director.

                  8. Service  Periods.  The periods of service as an employee or
director in connection with the grant of the Option are as follows:

                  [Conform to the replaced Out-of-the-Money Option.]

                  9.  Epitope Shares.

                  9.1  Mandatory  Issuance.  Upon  any  exercise  of  all or any
portion of the Option,  Participant  shall  receive,  in lieu of shares of Stock
otherwise issuable pursuant to this Option,  fully paid and nonassessable shares
(the "Exchange


                                      - 5 -
<PAGE>


Shares") of Common Stock, no par value, of Epitope (the "Epitope Common Stock"),
based upon a ratio of 2.433  shares of Stock for each  share of  Epitope  Common
Stock (the "Exchange Ratio"). In connection with any issuance under this Section
9.1  resulting in a fractional  share  interest of Epitope  Common  Stock,  such
interest  shall,  if less than 0.5 share,  be rounded down to the nearest  whole
share, and otherwise be rounded up to the nearest whole share. Corporation shall
purchase the  Exchange  Shares from  Epitope  pursuant to a separate  agreement.
Epitope's  obligation to issue the Exchange  Shares  pursuant to such  agreement
shall be a  condition  precedent  to  Participant's  obligation  to  accept  the
Exchange Shares pursuant to this Section 9.1.

                  9.2 Procedure. Upon exercise of the Option,  Corporation shall
cause  Epitope,  pursuant to the  separate  agreement  between  Corporation  and
Epitope described above, to issue a certificate or certificates for the Exchange
Shares in Participant's  name. As promptly as practicable  after exercise of the
Option, Corporation at its expense shall cause to be delivered to Participant:

                  (a) A certificate or certificates for the Exchange Shares;

                  (b) A copy of the prospectus  deliverable  in connection  with
         the registration of the Exchange Shares pursuant to Section 10.2 below,
         if applicable; and

                  (c) A statement  setting forth (A) the aggregate amount of the
         Stock for which the Option is exercised and (B) the  calculation of the
         number of shares of Epitope Common Stock to be issued.

                  9.3 Reservation of Stock Issuable Upon Exchange. Epitope shall
at all times  reserve and keep  available  out of its  authorized  but  unissued
shares of Epitope  Common  Stock,  such  number of its shares of Epitope  Common
Stock as shall from time to time be sufficient to effect the  provisions of this
Section 9; and if at any time the number of  authorized  but unissued  shares of
Epitope Common Stock shall not be sufficient to do so, in addition to such other
remedies  as shall be  available  to  Participant,  Epitope  shall  use its best
efforts to take such corporate action as may, in the opinion of its counsel,  be
necessary to increase its authorized but unissued shares of Epitope Common Stock
to such number of shares as shall be sufficient for such purposes.

                  9.4  Ratio Adjustment.

                  (a) Adjustments for Stock Splits and Subdivisions.  If Epitope
should  at any  time or from  time to time  fix a  record  date  for a split  or
subdivision  of  the   outstanding   shares  of  Epitope  Common  Stock  or  the
determination  of holders of Epitope Common Stock entitled to receive a dividend
or other  distribution  payable in additional  shares of Epitope Common Stock or
other securities or rights


                                      - 6 -
<PAGE>


convertible  into,  or  entitling  the holder  thereof to  receive  directly  or
indirectly,  additional  shares of Epitope Common Stock  ("Epitope  Common Stock
Equivalents")  without  payment  of any  consideration  by such  holder  for the
additional   shares  of  Epitope  Common  Stock  or  the  Epitope  Common  Stock
Equivalents  (including the  additional  shares of Epitope Common Stock issuable
upon conversion or exercise thereof),  then, as of such record date (or the date
of such  dividend,  distribution,  split or  subdivision  if no  record  date is
fixed), the Exchange Ratio shall be appropriately adjusted so that the number of
shares of Epitope  Common Stock  issuable  upon  exercise of the Option shall be
increased in proportion to such increase of outstanding shares.

                  (b)  Adjustments  for Reverse Stock  Splits.  If the number of
shares  of  Epitope  Common  Stock  outstanding  at any time is  decreased  by a
combination of the outstanding  shares of Epitope Common Stock,  then, as of the
record date for such  combination (or the date of such  combination if no record
date is fixed),  the Exchange Ratio shall be appropriately  adjusted so that the
number of shares of Epitope  Common  Stock  issuable  on  exercise of the Option
shall be decreased in proportion to such decrease in outstanding shares.

                  9.5  Holdback   Agreements.   Participant  hereby  agrees,  if
requested by Epitope and an  underwriter  of an offering of Epitope  securities,
that it shall not sell any Epitope  Common Stock for a period of time  specified
by the  underwriter  (not to exceed 90 days)  following the effective  date of a
registration statement pursuant to which Epitope proposes to sell its securities
to the public  generally;  provided,  however,  that all executive  officers and
directors of Epitope  enter into  similar  agreements.  Participant  agrees that
Epitope  shall have sole  discretion  to determine  whether and on what terms to
undertake any public offering of its securities.

                  9.6  Restriction  on Transfer of Shares  Issued.  In the event
that the registration  statement provided for in Section 10.2 below covering the
Exchange Shares has not been declared  effective at the time any Exchange Shares
are issued  under this Section 9, any such  Exchange  Shares shall bear a legend
stating that the Exchange Shares have not been registered under the 1933 Act and
may not be offered,  sold,  transferred,  pledged,  or otherwise disposed of, in
whole or in part,  unless the  transaction is registered  under the 1933 Act and
applicable state securities laws, unless, in the opinion of counsel for Epitope,
such   registration  is  not  required.   Prior  to  the  effectiveness  of  the
registration  statement  covering the Exchange  Shares,  Epitope shall refuse to
register on its books any  purported  transfer  of  Exchange  Shares not made in
accordance with the 1933 Act and this Agreement, and any such purported transfer
shall be void.

                  9.7 No Shareholder Rights. Nothing contained in this Agreement
shall be construed as conferring upon  Participant or any other person the right
to vote on or consent to matters submitted to shareholders, to receive notice as
a shareholder in respect of meetings of shareholders,  to receive dividends,  or
to exercise any


                                      - 7 -
<PAGE>


other rights  whatsoever as a  shareholder  of Epitope,  until,  and only to the
extent that, Participant shall have received shares of Epitope Common Stock.

                  9.8 Condition Precedent. The Company will use its best efforts
to obtain  approval by Epitope of its  obligations  under this Agreement and the
agreement described in Section 9.1 pursuant to which the Exchange Shares will be
obtained from Epitope.  If the Company  determines  that such approval cannot be
obtained or that such agreement cannot be entered into with Epitope,  the Option
shall terminate on notice to Participant to that effect.

                  10.  Registration Rights.

                  10.1 Definitions.

                  (a) The  terms  "register,"  "registered,  and  "registration"
refer  to a  registration  effected  by  preparing  and  filing  a  registration
statement  or  similar  document  in  compliance  with  the  1933  Act  and  the
declaration  or ordering of  effectiveness  of such  registration  statement  or
document.

                  (b) The term Registrable Securities means the Exchange Shares.
As to any particular  Registrable  Securities,  such securities will cease to be
Registrable  Securities when (i) they have been effectively registered under the
1933 Act and disposed of in accordance with the registration  statement covering
them,  or  (ii)  they  are  transferred  pursuant  to Rule  144 (or any  similar
provision that is in force) under the 1933 Act.

                  10.2 Epitope  Registration.  As soon as practicable  after the
delivery of this  Agreement to  Participant,  Epitope shall file a  registration
statement on Form S-3 or S-8 or other applicable form (the "Epitope Registration
Statement")  covering  the  Epitope  Common  Stock  for  which  the Stock may be
exchanged  unless  such stock is already  registered,  and prepare and file such
amendments  and  supplements to such  registration  statement and the prospectus
used in connection  therewith as may be necessary to comply with the  provisions
of the 1933 Act with respect to disposition  of all  securities  covered by such
registration statement.  Epitope shall use its best efforts to cause the Epitope
Registration  Statement to become  effective  under the 1933 Act and to maintain
the effectiveness of the Epitope  Registration  Statement for a period ending on
the earlier of (i) one year after the date by which all Stock issuable  pursuant
to the Plan has been  exchanged for Epitope  Common  Stock,  and (ii) such other
date by which the holders of  Registrable  Securities  have sold all the Epitope
Common  Stock into  which the Stock is  exchangeable  or by and after  which the
holders of  Registrable  Securities  may sell the Epitope  Common Stock  without
registration  under the 1933 Act. If required by applicable  law,  Epitope shall
furnish to the  holders of  Registrable  Securities  such  reasonable  number of
copies of a prospectus, in conformity with the requirements of the 1933 Act, and
any amendments or supplements thereto and such other


                                      - 8 -
<PAGE>


documents as the holders of Registrable  Securities  may  reasonably  request in
order to facilitate the  disposition  of the  Registrable  Securities  after the
Epitope  Registration  Statement has been declared effective.  Epitope shall use
reasonable  efforts  to notify  the  holders of  Registrable  Securities  when a
prospectus relating to Registrable  Securities is required to be delivered under
the 1933 Act, to notify the holders of  Registrable  Securities of the happening
of any  event as a result  of  which  the  prospectus  included  in the  Epitope
Registration  Statement,  as then in effect,  includes an untrue  statement of a
material fact or omits to state a material fact required to be stated therein or
necessary  to make  the  statements  therein  not  misleading  in  light  of the
circumstances then existing, to promptly file such amendments and supplements as
may be required on account of such event,  and to use its best  efforts to cause
each such amendment to become effective.  The holders of Registrable  Securities
shall not effect sales of  Registrable  Securities  after receipt of notice from
Epitope that any such amendment or supplement is required on account of any such
event,  until the amendment  becomes effective or the supplement has been filed.
Epitope's obligations under this Section 10.2 shall expire at such time as it is
no longer  required to maintain the  effectiveness  of the Epitope  Registration
Statement as provided for above.

                  10.3  Preparation; Information; Reasonable Investigation.

                  (a) Furnish Information.  It shall be a condition precedent to
Epitope's  obligations  under  Section  10.2  that the  holders  of  Registrable
Securities shall furnish to Epitope such information regarding  themselves,  the
Registrable  Securities  held by them, and the intended method of disposition of
such  securities  as shall be  required  to  effect  the  registration  of their
Registrable Securities, and shall agree to be bound by the terms of this Section
10 if such holders are not already parties to this Agreement.

                  (b) Preparation;  Reasonable Investigation. In connection with
the  preparation  and filing of any  registration  statement  under the 1933 Act
pursuant to Section 10.2 above,  Epitope  shall give the holders of  Registrable
Securities registered under such registration statement, their underwriters, and
their  respective  counsel and accountants the opportunity to participate in the
preparation of such registration statement,  each prospectus included therein or
filed with the SEC, and each amendment thereof or supplement thereto,  and shall
give each of them such access to its books and records and such opportunities to
discuss  Epitope's  business  with  its  officers  and  the  independent  public
accountants  who have certified its financial  statements as shall be necessary,
in the opinion of such holders' and such underwriters'  respective  counsel,  to
conduct a reasonable investigation within the meaning of the 1933 Act.

                  10.4  Expenses  of  Registration.  All  expenses  relating  to
Registrable  Securities  (other than  underwriting  discounts  and  commissions,
transfer taxes, if any, and fees and  disbursements of counsel to the holders of
Registrable


                                      - 9 -
<PAGE>


Securities)   incurred  in  connection  with  the   registrations,   filings  or
qualifications  pursuant to Section 10.2 above, including without limitation all
registration,  filing and qualification  fees, printing and accounting fees, and
fees and disbursements of counsel for Epitope, shall be borne by Epitope.

                  10.5 Indemnification.  In the event any Registrable Securities
are included in a registration statement under this Section 10:

                  (a)  Registering  Corporation  Indemnification.  To the extent
         permitted by law, Epitope shall indemnify and hold harmless each holder
         of Registrable Securities, the officers,  directors,  partners, agents,
         and employees of each holder or any underwriter (as defined in the 1933
         Act) for such holder, and each person, if any, who controls such holder
         or  underwriter  within the  meaning of the 1933 Act or the  Securities
         Exchange Act of 1934, as amended (the "1934 Act"),  against any losses,
         claims,  damages,  or liabilities  (joint or several) to which they may
         become  subject  under the 1933 Act, the 1934 Act, or other  federal or
         state law, insofar as such losses, claims,  damages, or liabilities (or
         actions in respect  thereof)  arise out of or are based upon any of the
         following statements, omissions or violations (a "Violation"):

                           (i) any untrue  statement or alleged untrue statement
                  of a material fact contained in such  registration  statement,
                  including  any  preliminary  prospectus  or  final  prospectus
                  contained therein or any amendments or supplements thereto,

                           (ii)  the  omission  or  alleged  omission  to  state
                  therein a  material  fact  required  to be stated  therein  or
                  necessary to make the statements therein not misleading, or

                           (iii) any  violation or alleged  violation by Epitope
                  of the 1933 Act,  the 1934 Act, any state  securities  law, or
                  any rule or  regulation  promulgated  under the 1933 Act,  the
                  1934 Act, or any state securities law.

         Epitope shall reimburse each such holder, officer,  director,  partner,
         agent,  employee,  underwriter or  controlling  person for any legal or
         other  expenses   reasonably   incurred  by  them  in  connection  with
         investigating or defending any such loss, claim, damage,  liability, or
         action. The indemnity agreement contained in this section 10.5(a) shall
         not apply to amounts paid in  settlement  of any loss,  claim,  damage,
         liability,  or action if such settlement is effected without  Epitope's
         consent (which consent shall not be unreasonably withheld),


                                     - 10 -
<PAGE>


         nor shall  Epitope  be liable to a holder in any such case for any such
         loss,  claim,  damage,  liability,  or action (A) to the extent that it
         arises out of or is based upon a  Violation  which  occurs in  reliance
         upon and in conformity with written information furnished expressly for
         use in  connection  with  such  registration  by or on  behalf  of such
         holder,  underwriter or controlling person or (B) in the case of a sale
         directly by a holder of  Registrable  Securities  (including  a sale of
         such Registrable  Securities  through any underwriter  retained by such
         holder to engage in a distribution solely on behalf of such holder), if
         such  untrue  statement  or alleged  untrue  statement  or  omission or
         alleged  omission  was  contained  in  a  preliminary   prospectus  and
         corrected in a final or amended  prospectus,  and such holder failed to
         deliver a copy of the final or  amended  prospectus  at or prior to the
         confirmation  of the sale of the  Registrable  Securities to the person
         asserting any such loss,  claim,  damage or liability in any case where
         such delivery is required by the 1933 Act.

                  (b) Holder  Indemnification.  To the extent  permitted by law,
         each holder of Registrable Securities shall indemnify and hold harmless
         Epitope,  each of its  directors,  each of its officers who have signed
         the registration  statement,  each person, if any, who controls Epitope
         within the meaning of the 1933 Act, each agent and any  underwriter for
         Epitope,  and  any  other  holder  of  Registrable  Securities  selling
         securities  in such  registration  statement  or any of its  directors,
         officers,  partners,  agents,  or  employees or any person who controls
         such holder or underwriter,  against any losses,  claims,  damages,  or
         liabilities  (joint or several) to which Epitope or any such  director,
         officer,  controlling  person,  agent,  or  underwriter  or other  such
         holder,  director,  officer or controlling  person may become  subject,
         under  the 1933 Act,  the 1934  Act,  or other  federal  or state  law,
         insofar as such losses,  claims,  damages or liabilities (or actions in
         respect thereto) arise out of or are based upon any Violation,  in each
         case to the extent (and only to the extent) that such Violation  occurs
         in reliance upon and in conformity with written  information  furnished
         by or on behalf of such holder  expressly  for use in  connection  with
         such  registration;  and each such holder shall  reimburse any legal or
         other  expenses  reasonably  incurred by Epitope or any such  director,
         officer,  controlling  person,  agent or  underwriter  or other holder,
         officer,  director,  partner,  agent, employee or controlling person in
         connection  with  investigating  or  defending  any such  loss,  claim,
         damage,  liability,  or action;  provided,  however, that the indemnity
         agreement  contained in this Section 10.5(b) shall not apply to amounts
         paid in  settlement  of any such loss,  claim,  damage,  liability,  or
         action if such  settlement  is  effected  without  the  consent  of the
         holder,  which consent shall not be  unreasonably  withheld nor, in the
         case of a sale directly by Epitope of


                                     - 11 -
<PAGE>


         its  securities  (including  a sale  of  such  securities  through  any
         underwriter  retained by Epitope to engage in a distribution  solely on
         behalf of  Epitope),  shall the holder be liable to Epitope in any case
         in which such untrue  statement or alleged untrue statement or omission
         or alleged  omission was  contained  in a  preliminary  prospectus  and
         corrected  in a final or  amended  prospectus,  and  Epitope  failed to
         deliver a copy of the final or  amended  prospectus  at or prior to the
         confirmation of the sale of the securities to the person  asserting any
         such loss,  claim,  damage or liability in any case where such delivery
         is  required  by  the  1933  Act;  and  provided,   further,  that  the
         indemnification  obligation  of each  holder  shall be  limited  to the
         aggregate  public offering price of the Registrable  Securities sold by
         such holder pursuant to such registration.

                  (c) Notice, Defense, and Counsel. Promptly after receipt by an
         indemnified party under this Section 10.5 of notice of the commencement
         of any action  (including any  governmental  action),  such indemnified
         party  shall,  if a claim in respect  thereof is to be made against any
         indemnifying party under this Section 10.5, deliver to the indemnifying
         party a written notice of the commencement thereof and the indemnifying
         party  shall have the right to  participate  in, and, to the extent the
         indemnifying  party so  desires,  jointly  with any other  indemnifying
         party similarly noticed, to assume and control the defense thereof with
         counsel mutually satisfactory to the parties;  provided,  however, that
         an  indemnified  party shall have the right to retain its own  counsel,
         with the fees and  expenses to be paid by the  indemnifying  party,  if
         representation of such indemnified party by the counsel retained by the
         indemnifying  party would be  inappropriate  due to actual or potential
         differing  interests between such indemnified party and any other party
         represented by such counsel in such proceeding.  The failure to deliver
         written notice to the  indemnifying  party within a reasonable  time of
         the  commencement of any such action,  if prejudicial to its ability to
         defend  such  action,  shall  relieve  such  indemnifying  party of any
         liability  to the  indemnified  party  under this  Section  10.5 to the
         extent of such prejudice, but the omission so to deliver written notice
         to the indemnifying party shall not relieve it of any liability that it
         may have to any  indemnified  party  otherwise  than under this Section
         10.5.

                  (d) Survival of Rights and  Obligations.  The  obligations  of
         Epitope and the holders of  Registrable  Securities  under this Section
         10.5 shall  survive  the  completion  of any  offering  of  Registrable
         Securities in a registration  statement whether under this Section 10.5
         or otherwise.


                                     - 12 -
<PAGE>


                  11.  Defined Terms.

                  When used in this  Agreement,  the following  terms shall have
the meanings specified below:

                  11.1  "Acquiring  Person"  shall  mean,  from  and  after  the
Registration  Date,  any  person or  related  person or  related  persons  which
constitute a "group" for purposes of Section 13(d) and Rule 13d-5 under the 1934
Act, as such  Section  and Rule are in effect as of the date of this  Agreement;
provided,  however, that the term Acquiring Person shall not include (a) Epitope
or any of its  Subsidiaries,  (b) any employee benefit plan of Epitope or any of
its  Subsidiaries,  (c) any entity holding voting capital stock of Epitope or of
any its  Subsidiaries  for or pursuant to the terms of any such employee benefit
plan, or (d) any person or group solely  because such person or group has voting
power with respect to capital  stock of  Corporation  or Epitope  arising from a
revocable  proxy or  consent  given in  response  to a public  proxy or  consent
solicitation made pursuant to the 1934 Act.

                  11.2  "Change in Control" shall mean:

                  (a) A change in control  of Epitope of a nature  that would be
         required to be  reported  in  response to Item 6(e) of Schedule  14A of
         Regulation 14A as in effect on the date of this  Agreement  pursuant to
         the 1934  Act;  provided  that,  without  limitation,  such a change in
         control  shall be deemed to have occurred at such time as any Acquiring
         Person  hereafter  becomes the  "beneficial  owner" (as defined in Rule
         13d-3  under the 1934 Act),  directly or  indirectly,  of 30 percent or
         more of the combined voting power of Voting Securities; or

                  (b)  During  any  period of 12  consecutive  calendar  months,
         individuals who at the beginning of such period  constitute the Epitope
         board of  directors  cease  for any  reason  to  constitute  at least a
         majority  thereof unless the election,  or the nomination for election,
         by  Corporation's  shareholders  of each new director was approved by a
         vote of at least a majority of the  directors  then still in office who
         were directors at the beginning of the period; or

                  (c) There shall be consummated (i) any consolidation or merger
         of  Epitope  in  which  Epitope  is not  the  continuing  or  surviving
         corporation or pursuant to which Voting  Securities  would be converted
         into  cash,  securities,  or other  property,  other  than a merger  of
         Epitope in which the holders of Voting Securities  immediately prior to
         the merger  have the same,  or  substantially  the same,  proportionate
         ownership  of common  stock of the  surviving  corporation  immediately
         after the merger, or (ii) any sale, lease,  exchange, or other transfer
         (in


                                     - 13 -
<PAGE>



         one transaction or a series of related transactions) of all, or
         substantially all, of the assets of Epitope; or

                  (d)  Approval  by the  shareholders  of Epitope of any plan or
         proposal for the liquidation or dissolution of Epitope.

                  11.3  "Change  in  Control  Date"  shall  mean the first  date
following the date of this Agreement on which a Change in Control has occurred.

                  11.4 "Effective Date" has the meaning assigned in Section 1.

                  11.5 "Epitope" means Epitope, Inc., an Oregon corporation.

                  11.6  "Option" has the meaning assigned in Section 1.

                  11.7  "Voting  Securities"  shall  mean  Epitope's  issued and
outstanding  securities  ordinarily  having the right to vote at  elections  for
Epitope's board of directors.

                  11.8 Capitalized terms not otherwise defined in this Agreement
have the meanings given them in the Plan.

                  12.  Miscellaneous.

                  12.1   Violation.   Notwithstanding   any  provision  of  this
Agreement to the contrary,  the Option shall not be  exercisable at any time, in
whole or in part, if issuance and delivery of the Stock or Exchange Shares would
violate any law or regulation.

                  12.2  Tax  Reimbursement.  In the  event  any  withholding  or
similar tax liability is imposed on Corporation or Epitope in connection with or
with  respect  to the  exercise  of the  Option,  Participant  agrees  to pay to
Corporation or Epitope an amount sufficient to provide for such tax liability.

                  12.3  Disputes.  Any  dispute or  disagreement  that may arise
under or as a result of this Agreement, or any question as to the interpretation
of  this  Agreement,  may be  determined  by  Corporation  in its  absolute  and
uncontrolled discretion, and any such determination shall be final, binding, and
conclusive on all affected persons.


                                     - 14 -
<PAGE>


                  12.4  Notices.  Any  notice  that a party may be  required  or
permitted  to  give to the  other  shall  be in  writing,  and may be  delivered
personally or by certified or registered mail,  postage prepaid,  at the address
set forth above, or at such other address as either party may designate by

                                           AGRITOPE, INC.


                                           By ----------------------------------
                                           Title: ------------------------------


                                           -------------------------------------
                                           Participant

Agreed to for purposes
of Sections 9.3 and 10

EPITOPE, INC.


By -----------------------------------
Title:



                                     - 15 -


                                 August 19, 1997







Mr. Roger L. Pringle
Chairman of the Board
Epitope, Inc.
8505 SW Creekside Place
Beaverton, OR  97008

Dear Roger:

          This will confirm my agreement with Epitope, Inc. (the "Company") made
in connection with recent management and strategic changes at the Company:

          1.  Effective  May 30,  1997,  I was  removed as  President  and Chief
Executive  Officer  of the  Company  by action of the Board of  Directors.  This
action   substantially   diminished  my  duties  and  title  and  constituted  a
"termination  without  cause" by the Company within the meaning of Section 5.2.1
of the Amended and  Restated  Employment  Agreement  dated as of January 8, 1991
between the Company and me (the "Employment Agreement").

          2. As a result of such termination, the Company is obligated to pay me
24 months of my regular salary as President and Chief  Executive  Officer of the
Company, as extraordinary compensation under Section 2.3 and Schedule 2.3 of the
Employment  Agreement.  Because I have  agreed to serve as  President  and Chief
Executive Officer of the Company's Agritope,  Inc. subsidiary  ("Agritope"),  we
have agreed that payment of the extraordinary  compensation will commence in the
first month  following  the earlier of (i)  termination  of my  employment  with
Agritope for any reason,  (ii) the closing of a transaction by which the Company
no longer controls Agritope (an "Agritope  Disposition"),  or (iii) the 90th day
(the "Cut-Off Date") after the Company's first public announcement of its intent
to proceed with a specific Agritope Disposition which is subsequently closed. If
payment of  extraordinary  compensation  is to commence under clause (iii),  any
salary  paid me by the  Company or any  subsidiary  for the period  between  the
Cut-Off  Date and the  closing of the  Agritope  Disposition  shall be  credited
against the obligation to pay me extraordinary compensation.


<PAGE>


Mr. Roger L. Pringle
August 19, 1997
Page 2



          3. My services as President  and Chief  Executive  Officer of Agritope
shall include the primary  responsibility  for arranging a transaction  by which
Agritope  can become a  corporation  separate  from the Company  through a sale,
spin-off, initial public offering or other corporate transaction.

          4.  Section  3.1  of the  Employment  Agreement  shall  not  apply  to
Confidential Information (as defined in Section 3.1) of Agritope to which I have
had access during my employment with the Company and Agritope.

          5. Section 4.1 of the Employment Agreement shall not apply to services
that I perform  for or on behalf of  Agritope  either  during  the time in which
Agritope  is owned by the  Company  or after it is no longer  controlled  by the
Company.

          6.  Termination  of my  employment  as President  and Chief  Executive
Officer of the Company  shall not  constitute a termination  of  employment  for
purposes  of any of the stock  option or stock  award  plans of the  Company  or
Agritope under which I now hold options. Any stock options held by me under such
plans,  which by their terms are slated to expire in 1997,  shall be extended or
exchanged  for new  stock  options  with  terms  consistent  with the  Company's
policies for executive compensation.

          7. The  Indemnification  Agreement  dated June 14,  1989  between  the
Company and me shall be amended or replaced by a new  agreement  to provide that
it applies to services  performed by me as a director,  officer and key employee
of Agritope through the date of an Agritope Disposition.

          8. The Company will pay my reasonable attorneys' fees related to these
changes in my employment arrangements not to exceed $2,500.

          9.  This   Agreement   constitutes  an  amendment  to  the  Employment
Agreement. Except as so amended, the terms of the Employment Agreement remain in
full force and effect.



<PAGE>


Mr. Roger L. Pringle
August 19, 1997
Page 2


          Please sign below to indicate  the  agreement  of the Company to these
terms.

                              Very truly yours,


                              /s/ Adolph J. Ferro
                              Adolph J. Ferro



The above terms are agreed to as of the above date:

EPITOPE, INC.



By: /s/ Roger L. Pringle
     Roger L. Pringle
     Chairman of the Board



By: /s/ W. Charles Armstrong
     W. Charles Armstrong
     President and Chief Executive
     Officer



                              EMPLOYMENT AGREEMENT


                  This  Employment  Agreement  is entered  into as of October 6,
1997,  between  John  W.  Morgan  ("Employee")  and  Epitope,  Inc.,  an  Oregon
corporation (the "Company").

                  1. SERVICES.

                           1.1 EMPLOYMENT. The Company agrees to employ Employee
as President and Chief  Executive  Officer of the Company,  and Employee  hereby
accepts such  employment  in  accordance  with the terms and  conditions of this
Agreement.  Employment shall continue until terminated  pursuant to the terms of
this Agreement.

                           1.2 DUTIES. Employee shall have the position named in
Section 1.1 with such powers and duties appropriate to that office (a) as may be
provided by the bylaws of the Company,  (b) as otherwise  set forth in Exhibit A
attached to this Agreement, and (c) as determined by the board of directors from
time to time.  Subject to the  provisions  of  Section  7.4  hereof,  Employee's
position  and duties may be  changed  from time to time  during the term of this
Agreement,  and Employee's place of work may be relocated at the sole discretion
of the board of directors.

                           1.3 OUTSIDE  ACTIVITIES.  Employee  shall  obtain the
consent  of the  board of  directors  before  he  engages,  either  directly  or
indirectly, in any other professional or business activities that may require an
appreciable  portion  of  Employee's  time or  effort  to the  detriment  of the
Company's business.

                           1.4  DIRECTION  OF  SERVICES.  Employee  shall at all
times  discharge his duties in  consultation  with and under the supervision and
direction of the board of directors.

                  2. COMPENSATION AND EXPENSES.

                           2.1 SALARY.  As compensation  for services under this
Agreement,  the Company shall pay to Employee a regular salary of $20,416.67 per
month.  Subject to the  provisions  of Section  7.4  hereof,  such salary may be
adjusted from time to time in the discretion of the board of directors.  Payment
shall  be made  on a  bi-weekly  basis,  less  all  amounts  required  by law or
authorized  by Employee to be  withheld or  deducted,  at such times as shall be
determined by the board of directors.  The board of directors may also authorize
payment to  Employee  of  bonuses  at such  times and in such  amounts as may be
determined by the board of directors.

                           2.2 ADDITIONAL  EMPLOYEE BENEFITS.  The Company shall
provide  for  Employee  life  insurance  in the amount of $1 million  payable to
Employee's  designated  beneficiary,  provided  the cost to the Company does not
exceed $10,000 per year. To the extent otherwise  eligible,  Employee shall also
be entitled to receive or participate in any additional


                                      - 1 -
<PAGE>


benefits,  including without limitation  medical and dental insurance  programs,
profit sharing or pension plans, and medical reimbursement plans, which may from
time to time be made available by the Company to corporate officers. The Company
may change or discontinue such benefits at any time in its sole discretion.

                           2.3 EXPENSES.  The Company shall  reimburse  Employee
for all  reasonable and necessary  expenses  incurred in carrying out his duties
under  this  Agreement.   The  Company  shall  further  reimburse  Employee  for
reasonable and necessary expenses incurred as follows: (a) Employee's reasonable
expenses  incurred in moving himself,  his family,  and his household goods from
Alpharetta,  Georgia to the Portland,  Oregon  metropolitan  area; (b) up to two
months  (which time period may be extended by the Company in its  discretion  at
Employee's  request) of  temporary  housing at a cost of up to $1,000 per month;
(c) one  round-trip,  coach  airline  ticket per month for  Employee  for travel
between Atlanta,  Georgia and Portland,  Oregon until Employee has relocated his
residence to the Portland,  Oregon  metropolitan  area; and (d) one  round-trip,
coach airline ticket for Employee's  spouse for travel between Atlanta,  Georgia
and  Portland,  Oregon for purposes of locating and obtaining a new residence in
the Portland,  Oregon  metropolitan area.  Employee shall present to the Company
from time to time an  itemized  account of such  expenses in such form as may be
required by the Company.  In  addition,  regarding  the  expenses  listed as (a)
above,  Employee shall obtain bids from at least two national  moving  companies
and select the  company  with the lowest  bid.  To the extent the  reimbursement
payments under this section are includable in Employee's net taxable income, the
Company shall pay Employee an  additional  amount so that the amount paid to him
under this section, less taxes at Employee's effective marginal tax rate, equals
the expenses to be reimbursed.

                           2.4 FEES. All compensation earned by Employee,  other
than pursuant to this Agreement,  as a result of services performed on behalf of
the Company or as a result of or arising out of any work done by Employee in any
way related to the scientific or business activities of the Company shall belong
to the Company.  Employee shall pay or deliver such  compensation to the Company
promptly upon receipt. For the purposes of this provision,  "compensation" shall
include,  but is not  limited to, all  professional  and  nonprofessional  fees,
lecture fees, expert testimony fees, publishing fees, royalties, and any related
income,  earnings,  or other  things  of  value;  and  "scientific  or  business
activities of the Company" shall include,  but not be limited to, any project or
projects  in which the  Company  is  involved  and any  subject  matter  that is
directly or indirectly researched,  tested, developed,  promoted, or marketed by
the Company.

                  3. STOCK  OPTIONS.  Employee has been granted a  non-qualified
option to purchase  350,000 shares of common stock of the Company at an exercise
price equal to 75 percent of the fair  market  value of the stock on the date of
grant.


                                      - 2 -
<PAGE>



                  4. CONFIDENTIAL INFORMATION.

                           4.1  DEFINED.   "Confidential   Information"  is  all
nonpublic  information relating to the Company or its business that is disclosed
to Employee,  that Employee produces,  or that Employee otherwise obtains during
employment.  "Confidential  Information" also includes information received from
third parties that the Company has agreed to treat as confidential.  Examples of
Confidential Information are:

                           4.1.1 Marketing plans.

                           4.1.2 Customer lists.

                           4.1.3 Product design and manufacturing information.

                           4.1.4 Financial information.

"Confidential  Information" does not include information which (a) is or becomes
generally  available  to the public  other than as a result of a  disclosure  by
Employee;  (b) becomes available to Employee on a  nonconfidential  basis from a
source other than the Company or its representatives,  provided that such source
is not known by Employee  to be bound by a  confidentiality  agreement  with the
Company or its  representatives  or otherwise  prohibited from  transmitting the
information to Employee by a contractual,  legal, or fiduciary  obligation;  (c)
can be demonstrated  by written  evidence or other  convincing  evidence to have
been known by Employee on a  nonconfidential  basis prior to its  disclosure  to
Employee  by  the  Company  or  one  of  its  representatives;  or  (d)  can  be
demonstrated by written or other  convincing  evidence to have been developed by
Employee in good faith and independent of Confidential Information.

                           4.2 ACCESS TO INFORMATION. Employee acknowledges that
in the course of his employment he will have access to Confidential Information,
that  such  information  is a  valuable  asset  of the  Company,  and  that  its
disclosure or unauthorized use will cause the Company substantial harm.

                           4.3  OWNERSHIP.   Employee   acknowledges   that  all
Confidential  Information  shall  continue to be the  exclusive  property of the
Company (or the third party that  disclosed it to the  Company),  whether or not
prepared  in  whole or in part by  Employee  and  whether  or not  disclosed  to
Employee or entrusted to his custody in  connection  with his  employment by the
Company.

                           4.4  NONDISCLOSURE  AND NONUSE.  Unless authorized or
instructed  in writing  by the  Company,  or  required  by  legally  constituted
authority,  Employee will not, except as required in the course of the Company's
business,  during  or  after  his  employment,  disclose  to  others  or use any
Confidential  Information,  unless and until,  and then only to the extent that,
such items become available to the public through no fault of Employee.


                                      - 3 -
<PAGE>


                           4.5 RETURN OF CONFIDENTIAL INFORMATION.  Upon request
by the  Company  during  or after  his  employment,  and  without  request  upon
termination  of  employment  pursuant to this  Agreement,  Employee will deliver
immediately  to  the  Company  all  written  or  tangible  materials  containing
Confidential Information without retaining any excerpts or copies.

                           4.6  DURATION.  The  obligations  set  forth  in this
Section 4 will continue beyond the term of employment of Employee by the Company
and for so long as Employee possesses Confidential Information.

                  5. MATERIALS  PREPARED AND INVENTIONS MADE DURING  EMPLOYMENT.
The  Company  shall be the  exclusive  owner  of all  materials,  concepts,  and
inventions Employee prepares,  develops, or makes (whether alone or jointly with
others) within the scope of his employment, and of all related rights (including
copyrights,   trademarks,   and  patents)  and  proceeds.   Without  limitation,
materials, concepts, and inventions that (a) relate to the Company's business or
actual or demonstrably  anticipated research or development,  or (b) result from
any work performed by Employee for the Company,  shall be considered  within the
scope of  Employee's  employment.  Employee  shall  promptly  disclose  all such
materials,  concepts,  and  inventions to the Company.  Employee  shall take all
action reasonably  requested by the Company to vest ownership of such materials,
consents,  and  inventions  in the  Company  and to permit the Company to obtain
copyright, trademark, patent, or similar protection in its name.

                  6.       NONCOMPETITION.

                           Employee covenants that Employee will not, throughout
the United  States,  either  individually  or as a director,  officer,  partner,
employee, agent,  representative,  or consultant with any business,  directly or
indirectly during the term of employment and for one year thereafter:

                           6.1 Engage or prepare to engage in any business  that
sells  products or services  competing  with those sold by the Company as of the
date of Employee's termination of employment with the Company;

                           6.2  Induce or attempt to induce any person who is an
employee of the Company  during the term of this covenant to leave the employ of
the Company; or

                           6.3 Solicit, divert, or accept orders for products or
services that are  substantially  competitive with the products or services sold
by the Company from any customer of the Company.

                  7. TERMINATION.

                           7.1  TERMINATION  UPON DEATH.  This  Agreement  shall
terminate immediately upon Employee's death.


                                      - 4 -
<PAGE>


                           7.2  TERMINATION BY EMPLOYEE.  Employee may terminate
his employment under this Agreement by 60 days' written notice to the Company.

                           7.3 TERMINATION BY THE COMPANY FOR CAUSE. The Company
may terminate Employee's  employment under this Agreement for cause at any time,
with or without advance notice.  For purposes of this Agreement,  "cause" means:
(a) a material breach of this Agreement by Employee;  (b) any willful or grossly
negligent  act by  Employee  which  causes  material  harm to the  Company;  (c)
Employee's refusal,  failure, or inability to perform any material job duties of
Employee;  (d) any act of fraud on the  Company,  any  criminal  act, or any act
involving moral  turpitude by Employee;  (e) the commission of any act in direct
competition with or materially detrimental to the best interests of the Company;
or (f)  excessive  absenteeism  by Employee.  The Company  reserves the right to
determine the facts giving rise to cause for termination and whether those facts
constitute cause for termination.  Notwithstanding the foregoing, Employee shall
not be deemed to have been  terminated  for cause  unless and until  there shall
have been delivered to Employee a copy of a resolution duly adopted by the board
of directors at a meeting of the board of directors (after  reasonable notice to
Employee  and an  opportunity  for  Employee  to be heard  before  the  board of
directors)  called and held for the purpose of finding whether in the good faith
opinion of the board of directors  Employee has engaged in conduct  constituting
cause as defined in this section.

                           7.4  TERMINATION BY THE COMPANY  WITHOUT  CAUSE.  The
Company may terminate  Employee's  employment under this Agreement without cause
by written notice to Employee. Employee may (but shall not be required to) elect
to treat any of the following  events as a termination  without cause,  provided
Employee acts within 60 days of the event:

                                    7.4.1 A material breach of this Agreement by
the Company and a failure by the Company to cure the breach within 30 days after
Employee has given written notice of the breach to the board of directors.

                                    7.4.2 A reduction in Employee's salary below
the amount  stated in Section  2.1  (except  as part of and in  proportion  to a
reduction in all executive  officers'  salaries) or a substantial  diminution in
Employee's duties or title below those or that stated in this Agreement.

                                    7.4.3  A  requirement  by the  Company  that
Employee  regularly  report other than to the board of directors or the chairman
of the board.

                                    7.4.4 A  relocation  by the  Company  of the
principal place where  Employee's  duties are to be performed to a place outside
of the Portland metropolitan area.

                                    7.4.5 A "Change of Control" of the  Company.
For  purposes of this  Agreement,  a "Change of Control"  shall mean a change of
control of a nature  that would be  required  to be reported in response to Item
6(e) of Schedule 14A of Regulation 14A as in effect on the date hereof  pursuant
to the  Securities  Exchange Act of 1934 (the  "Exchange  Act");  provided that,
without limitation, such a change of control shall be deemed to have occurred at


                                      - 5 -
<PAGE>


such time as (i) any Acquiring Person hereafter  becomes the "beneficial  owner"
(as defined in Rule 13d-3 under the Exchange Act), directly or indirectly, of 30
percent or more of the combined voting power of Voting  Securities;  (ii) during
any period of 12 consecutive  calendar months,  individuals who at the beginning
of such  period  constitute  the  board of  directors  cease  for any  reason to
constitute at least a majority  thereof  unless the election,  or the nomination
for election, by the Company's shareholders of each new director was approved by
a vote of at least a  majority  of the  directors  then still in office who were
directors at the beginning of the period;  (iii) there shall be consummated  (a)
any  consolidation  or merger of the  Company  in which the  Company  is not the
continuing or surviving corporation or pursuant to which Voting Securities would
be converted into cash,  securities,  or other property,  other than a merger of
the Company in which the holders of Voting  Securities  immediately prior to the
merger have the same,  or  substantially  the same,  proportionate  ownership of
common stock of the surviving  corporation  immediately after the merger, or (b)
any sale, lease,  exchange, or other transfer (in one transaction or a series of
related  transactions)  of all,  or  substantially  all,  of the  assets  of the
Company;  or (iv)  approval  by the  shareholders  of the Company of any plan or
proposal for the liquidation or dissolution of the Company. For purposes of this
Agreement,  "Acquiring  Person"  means  any  person  or  related  persons  which
constitute  a "group"  for  purposes  of Section  13(d) and Rule 13d-5 under the
Exchange  Act,  as such  Section  and Rule are in  effect as of the date of this
Agreement;  provided, however, that the term Acquiring Person shall not include:
(i) the Company or any of its  subsidiaries;  (ii) any employee  benefit plan of
the Company or any of its subsidiaries;  (iii) any entity holding voting capital
stock of the Company for or pursuant to the terms of any such  employee  benefit
plan; or (iv) any person or group solely because such person or group has voting
power with  respect to capital  stock of the  Company  arising  from a revocable
proxy or consent  given in  response to a public  proxy or consent  solicitation
made  pursuant to the  Exchange  Act. For  purposes of this  Agreement,  "Voting
Securities"  means the Company's  issued and outstanding  securities  ordinarily
having the right to vote at elections for the Company's board of directors.

                           7.5 COMPENSATION UPON TERMINATION.

                                    7.5.1 TERMINATION UNDER SECTION 7.1, 7.2, OR
7.3. In the event of a termination of Employee's  employment under Sections 7.1,
7.2, or 7.3,  Employee's regular  compensation  pursuant to Section 2.1 shall be
prorated and payable until the date of termination.

                                    7.5.2  TERMINATION UNDER SECTION 7.4. In the
event of a termination of Employee's  employment by the Company without cause as
provided in Section 7.4,  Employee shall continue to be paid the salary provided
in  Section  2.1 for 12 months  from the date of notice of such  termination  of
employment,  in the manner and at the times at which  regular  compensation  was
paid to Employee during the term of his employment under this Agreement,  except
that if Employee elects to treat an event  described in Sections  7.4.1,  7.4.2,
7.4.3,  7.4.4, or 7.4.5 as a termination without cause but continues to work for
the Company or any of its  subsidiaries,  then any amounts Employee  receives as
compensation  during the 12- month period shall be credited  against the amounts
payable to  Employee  under this  section.  Unless  Employee  elects to continue
working for the Company or any of its subsidiaries, as a condition to receipt of
the compensation described in the preceding sentence Employee shall sign


                                      - 6 -
<PAGE>


and  deliver a release  agreement,  in form and  substance  satisfactory  to the
Company,  releasing all claims related to Employee's  employment.  The Company's
obligation to pay the amounts stated in this section shall terminate if Employee
engages,  either  individually  or as a director,  officer,  partner,  employee,
agent,  representative,  or consultant with any business, directly or indirectly
in any of the  activities  listed in Section  6.1,  6.2, or 6.3  anywhere in the
United States within one year after termination of employment.

                  8. REMEDIES.  The respective  rights and duties of the Company
and Employee  under this Agreement are in addition to, and not in lieu of, those
rights  and  duties  afforded  to and  imposed  upon  them by law or at  equity.
Employee  acknowledges  that  breach of Sections 4 or 6 of this  Agreement  will
cause  irreparable  harm to the  Company  and agrees to the entry of a temporary
restraining   order  and   permanent   injunction  by  any  court  of  competent
jurisdiction  to  prevent  breach or further  breach of  Sections 4 or 6 of this
Agreement. Such remedy shall be in addition to any other remedy available to the
Company at law or in equity.

                  9.   SEVERABILITY  OF  PROVISIONS.   The  provisions  of  this
Agreement  are  severable,  and if any  provision  hereof  is  held  invalid  or
unenforceable,  it shall be enforced to the maximum extent permissible,  and the
remaining provisions of the Agreement shall continue in full force and effect.

                  10.  ATTORNEY  FEES. In the event a suit or action is filed to
enforce  Sections  4 or 6 of this  Agreement,  the  prevailing  party  shall  be
reimbursed by the other party for all costs and expenses  incurred in connection
with the suit or action,  including without limitation  reasonable attorney fees
at trial or on appeal.

                  11.  NONWAIVER.  Failure of the Company at any time to require
performance of any provision of this Agreement  shall not limit the right of the
Company to enforce the  provision.  No  provision  of this  Agreement  or breach
thereof may be waived by either party except by a writing  signed by that party.
A waiver of any  breach of a  provision  of this  Agreement  shall be  construed
narrowly and shall not be deemed to be a waiver of any succeeding breach of that
provision or a waiver of that provision itself or of any other provision.

                  12. ARBITRATION.

                           12.1  CLAIMS  COVERED.  All claims or  controversies,
except for those excluded by Section 12.2 ("claims"), whether or not arising out
of Employee's employment (or its termination), that the Company may have against
the  Employee  or that  Employee  may have  against  the  Company or against its
officers,  directors,  employees  or  agents,  in  their  capacity  as  such  or
otherwise,  shall be resolved as provided in this Section 12. Claims  covered by
this  Section 12  include,  but are not  limited  to,  claims for wages or other
compensation  due;  claims for breach of any  contract or  covenant  (express or
implied); tort claims; claims for discrimination (including, but not limited to,
race, sex, sexual orientation,  religion,  national origin, age, marital status,
or disability); claims for benefits (except where an employee benefit or pension
plan  specifies  that its claims  procedure  shall  culminate in an  arbitration
procedure


                                      - 7 -
<PAGE>


different  from this one),  and claims for violation of any federal,  state,  or
other governmental law, statute, regulation, or ordinance, except as provided in
Section 12.2.

                           12.2  NON-COVERED  CLAIMS.   Claims  arising  out  of
Sections 4 or 6 of this  Agreement  and workers'  compensation  or  unemployment
compensation  benefits  are not covered by this Section 12.  Non-covered  claims
include but are not limited to claims by the Company for injunctive and/or other
equitable  relief for  unfair  competition  and/or  the use and/or  unauthorized
disclosure of trade secrets or  confidential  information,  as to which Employee
understands  and agrees that the Company may seek and obtain relief from a court
of competent jurisdiction.

                           12.3  REQUIRED  NOTICE OF ALL CLAIMS  AND  STATUTE OF
LIMITATIONS.  Company  and  Employee  agree that the  aggrieved  party must give
written  notice of any claim to the other party  within one year of the date the
aggrieved  party  first has  knowledge  of the event  giving  rise to the claim;
otherwise  the claim shall be void and deemed  waived even if there is a federal
or state statute of  limitations  which would have given more time to pursue the
claim.  The written  notice shall identify and describe the nature of all claims
asserted and the facts upon which such claims are based.

                           12.4 HEARING OR MEDIATION.  Prior to any  arbitration
proceeding  taking place  pursuant to this section,  Company or Employee may, at
its respective option, elect to submit the claim to non-binding mediation before
a mutually agreeable mediation tribunal or mediator, in which event both parties
shall execute a suitable  confidentiality  agreement and abide by the procedures
specified by the mediation tribunal or mediator.

                           12.5 ARBITRATION PROCEDURES. Any arbitration shall be
conducted in  accordance  with the  then-current  Model  Employment  Arbitration
Procedures  of  the  American  Arbitration  Association  ("AAA"),   modified  to
substitute for AAA actions,  the United States Arbitration and Mediation Service
("USA&MS"), before an arbitrator who is licensed to practice law in the state of
Oregon (the "Arbitrator"). The arbitration shall take place in or near Portland,
Oregon.

                                    12.5.1  SELECTION OF ARBITRATOR.  The USA&MS
shall  give  each  party  a list of 11  arbitrators  drawn  from  its  panel  of
labor-management  dispute  arbitrators.  Each  party may strike all names on the
list it deems unacceptable.  If only one common name remains on the lists of all
parties, that individual shall be designated as the Arbitrator. If more than one
common name remains on the lists of all parties,  the parties shall strike names
alternately  until only one  remains.  The party who did not  initiate the claim
shall strike first.  If no common name remains on the lists of all parties,  the
USA&MS  shall  furnish  an  additional  list or  lists  until an  Arbitrator  is
selected.

                                    12.5.2  APPLICABLE LAW. The Arbitrator shall
apply the substantive law (and the law of remedies,  if applicable) specified in
this Agreement or federal law, or both, as applicable to the claim(s)  asserted.
The Oregon Rules of Evidence shall apply.  The Arbitrator,  and not any federal,
state, or local court or agency, shall have exclusive


                                      - 8 -
<PAGE>


authority to resolve any dispute relating to the interpretation,  applicability,
enforceability or formation of this Agreement,  including but not limited to any
claim  that  all or any  part  of  this  Agreement  is  void  or  voidable.  The
arbitration  shall be final and binding upon the parties,  except as provided in
this Agreement.

                                    12.5.3 AUTHORITY.  The Arbitrator shall have
jurisdiction to hear and rule on pre-hearing  disputes and is authorized to hold
pre-hearing  conferences  by  telephone  or in  person as the  Arbitrator  deems
necessary.  The  Arbitrator  shall have the  authority  to entertain a motion to
dismiss  and/or a motion for  summary  judgment by any party and shall apply the
standards governing such motions under the Federal Rules of Civil Procedure. The
Arbitrator  shall render an award and opinion in the form typically  rendered in
labor arbitrations.

                                    12.5.4  REPRESENTATION.  Any  party  may  be
represented by an attorney or other representative selected by the party.

                                    12.5.5 DISCOVERY.  Each party shall have the
right to take the deposition of one individual and any expert witness designated
by another  party.  Each party  also shall have the right to make  requests  for
production of documents to any party.  The subpoena right  specified below shall
be applicable to discovery pursuant to this paragraph.  Additional discovery may
be had only where the Arbitrator  selected pursuant to this Agreement so orders,
upon a showing of substantial need. At least 30 days before the arbitration, the
parties must exchange lists of witnesses,  including any experts,  and copies of
all exhibits  intended to be used at the arbitration.  Each party shall have the
right to subpoena witnesses and documents for the arbitration.

                                    12.5.6   REPORTER.   Either  party,  at  its
expense,  may  arrange  for and pay the cost of a court  reporter  to  provide a
stenographic record of proceedings.

                                    12.5.7  POST-HEARING  BRIEFS.  Either party,
upon  request  at  the  close  of  hearing,  shall  be  given  leave  to  file a
post-hearing  brief.  The  time  for  filing  such a brief  shall  be set by the
Arbitrator.

                           12.6 ENFORCEMENT. Either party may bring an action in
any court of competent  jurisdiction to compel  arbitration under this Agreement
and to  enforce an  arbitration  award.  Except as  otherwise  provided  in this
Agreement,  both the Company and Employee  agree that neither shall  initiate or
prosecute  any lawsuit or  administrative  action  (other than for a non-covered
claim)  in any way  related  to any claim  covered  by this  Agreement.  A party
opposing enforcement of an award may not do so in an enforcement proceeding, but
must bring a separate action in any court of competent jurisdiction to set aside
the award,  where the  standard of review will be the same as that applied by an
appellate court reviewing a decision of a trial court sitting without a jury.

                           12.7 ARBITRATION FEES AND COSTS. Company and Employee
shall  equally  share  the fees and costs of the  Arbitrator.  Each  party  will
deposit funds or post other


                                      - 9 -
<PAGE>


appropriate  security  for its share of the  Arbitrator's  fee, in an amount and
manner  determined by the  Arbitrator,  10 days before the first day of hearing.
Each party shall pay for its own costs and  attorneys'  fees,  if any,  provided
that the Arbitrator,  in its sole  discretion,  may award reasonable fees to the
prevailing party in a proceeding.

                  13. GENERAL TERMS AND CONDITIONS.  This Agreement  constitutes
the entire  understanding  of the parties relating to the employment of Employee
by the Company,  and  supersedes  and  replaces all written and oral  agreements
heretofore made or existing by and between the parties  relating  thereto.  This
Agreement shall be construed in accordance with the laws of the state of Oregon,
without  regard to any conflicts of laws rules  thereof.  This  Agreement  shall
inure to the benefit of any  successors or assigns of the Company.  All captions
used herein are intended solely for convenience of reference and shall in no way
limit any of the provisions of this  Agreement.  Employee  acknowledges  that he
signed this Agreement upon his initial employment with the Company.

                  The parties have executed this Employment  Agreement as of the
date stated above.


                                       EPITOPE, INC.



/s/ John W. Morgan                     By: /s/ Roger L. Pringle
JOHN W. MORGAN
                                       Title:  Chairman, Board of Directors


                                     - 10 -
<PAGE>


                        EXHIBIT A TO EMPLOYMENT AGREEMENT

      SPECIFIC DUTIES OF EMPLOYEE AS PRESIDENT AND CHIEF EXECUTIVE OFFICER


                  Employee as the President and Chief  Executive  Officer of the
Company shall be responsible  for directing all phases of the operations and the
overall  management  of the  Company,  subject  to  direction  by the  board  of
directors,  as such positions are more  particularly  described in Article IV of
the bylaws of the Company.  As President and Chief Executive  Officer,  Employee
shall report directly to the Chairman of the Board. In such capacities, Employee
shall be the key executive  responsible for formulating and directing  execution
of Company strategy in all phases of operations,  development,  and planning. As
Chief Executive Officer,  Employee shall be the Company's principal spokesperson
and  will  serve  as a  director  on the  board of  directors  and as  operating
management's principal liaison to the board of directors.

                  Pending the  spin-off of the  Company's  subsidiary  Agritope,
Inc.  ("Agritope"),  the President and Chief Executive Officer of Agritope shall
report to the Chairman of the Board of the Company, rather than to Employee.


                         NONQUALIFIED STOCK OPTION AWARD
                          GENERAL TERMS AND CONDITIONS

                              - EXECUTIVE OFFICER -


The  Epitope,  Inc.  1991  Stock  Award Plan  ("Plan")  is  administered  by the
executive  compensation committee (the "Committee") of the board of directors of
Epitope.  Capitalized  terms not otherwise  defined  shall have the  definitions
assigned thereto in Section 13 of these  Nonqualified Stock Option Award General
Terms and Conditions ("Agreement Terms").


1                 OPTION TYPE AND TERM.

         1.1               TYPE OF OPTION.  The Option is not  intended to be an
                  incentive  stock option as described in Internal  Revenue Code
                  Section 422.

         1.2               TERM.  The term of the Option shall be ten years from
                  the Grant Date  unless  otherwise  terminated  pursuant to the
                  terms of these Agreement Terms.

         1.3               VESTING.   Except  as  otherwise  provided  in  these
                  Agreement  Terms,  the  Option  shall  be  vested  as to,  and
                  accordingly may be exercised from time to time during the term
                  to  purchase,  Shares up to the  following  limits  during the
                  periods indicated following the Grant Date:

                  (a)  During  the  period  from  the  Grant  Date to the  first
                  anniversary  of the Grant Date (the  "First  Anniversary")  no
                  portion of the Option will be vested;

                  (b)  Effective  as of the First  Anniversary,  the Option will
                  become  vested as to  one-third  (1/3) of the total  number of
                  Shares covered by the Option (the "Option Shares"); and

                  (c)  Effective  as of  the  day  corresponding  to  the  First
                  Anniversary in the calendar month following the month in which
                  the First Anniversary  occurs, and on the corresponding day of
                  each succeeding  calendar month, the Option will become vested
                  as to  one-twenty-fourth  (1/24) of the Option Shares that did
                  not become vested pursuant to the foregoing paragraph (b).


                                      - 1 -
<PAGE>


2                 EMPLOYMENT REQUIREMENT.

         2.1               GENERAL.  Except as  provided  in Sections 3 and 4 of
                  these Agreement  Terms,  the Option shall not be vested unless
                  the recipient of the Option (the "Participant") is employed by
                  Epitope and/or one or more of its Subsidiaries (an "Employer")
                  continuously  for at least  one year  after  the  Grant  Date,
                  unless   employment  is   terminated  by  death,   Disability,
                  Retirement,  or without  "cause" (as defined in  Participant's
                  employment agreement with Epitope).  "Employment" for purposes
                  of the Option shall include periods of illness or other leaves
                  of absence authorized by Employer.

         2.2               NO  EMPLOYMENT  CONTRACT.  Neither  the  Plan nor the
                  Option   shall   constitute  a  contract  of   employment   of
                  Participant by any Employer.

         2.3               EXPIRATION  AFTER   TERMINATION  OF  EMPLOYMENT.   If
                  Participant  ceases  to be an  active  employee,  the right to
                  exercise the Option  shall expire at the end of the  following
                  periods:

                  After Termination
                    On Account Of                              Period
                  -----------------                            ------

                           Death                               1 year
                           Retirement                          5 years
                           Disability                          1 year
                           Any other reason                    1 year

         2.4      EFFECT OF TERMINATION  ON VESTING.  The Shares as to which the
                  Option is  exercisable  under Section 2.3 shall be those as to
                  which the Option is vested as of  termination  of  employment;
                  provided,  however,  that upon  Participant's  termination  of
                  employment  by the  Company  without  "cause"  (as  defined in
                  Participant's employment agreement with Epitope),  Participant
                  shall be  credited  with  vesting  during the period of salary
                  continuation paid by the Company.

3                 ACCELERATION OF EXERCISABILITY. Upon a Change in Control Date,
         the Option shall become immediately and fully vested and exercisable as
         to all Shares covered by the Option.


                                      - 2 -
<PAGE>



4                 EXERCISE PRIOR TO VESTING PERMITTED

         4.1               CONDITIONS   OF  EARLY   EXERCISE.   Subject  to  the
                  provisions of this Section 4,  Participant  may elect,  at any
                  time prior to  termination  of  Employment  with an  Employer,
                  including  without  limitation a time prior to the date(s) the
                  Option  becomes  vested  pursuant  to  Section  1.3  of  these
                  Agreement Terms, to exercise the Option (an "Early  Exercise")
                  as to all or any portion of the Shares  covered by the Option,
                  provided, however, that:

                  (a) A partial  exercise of the Option shall be deemed to cover
                  first  any  vested  Shares  and  then  the  earliest   vesting
                  installment of unvested Shares;

                  (b)  Participant  must  enter  into an  Early  Exercise  Stock
                  Purchase  Agreement  (a  "Purchase  Agreement")  in  the  form
                  attached to these Agreement Terms with a vesting schedule that
                  will  result in the same  vesting as to the  Shares  purchased
                  pursuant  to the Early  Exercise as if no Early  Exercise  had
                  occurred; and

                  (c) Any  Shares  purchased  pursuant  to Early  Exercise  from
                  installments  that have not vested as of the time of  exercise
                  shall be subject  to a purchase  option in favor of Epitope as
                  described in the Purchase Agreement.

         4.2               EXPIRATION OF EARLY EXERCISE  ELECTION.  The election
                  provided by this  Section 4 to  purchase  Shares upon an Early
                  Exercise  shall  cease  upon   Participant's   termination  of
                  Employment  with an Employer  and may not be  exercised  after
                  such termination.

5                 SERVICE  PERIODS.  The  periods of service as an  employee  in
         connection with the grant of the Option are as follows:

         5.1               FIRST  YEAR.   The  portion  of  the  Option  vesting
                  pursuant to Section  1.3(b) is in connection  with services to
                  be performed in the one-year  period  commencing  on the Grant
                  Date.

         5.2               ADDITIONAL  YEARS. The portions of the Option vesting
                  in  monthly  installments  pursuant  to  Sections  1.3(c)  are
                  respectively  in  connection  with services to be performed in
                  the consecutive monthly


                                      - 3 -
<PAGE>


                  periods ending immediately before each monthly vesting
                  date.

6                 METHOD OF EXERCISE.

         6.1               EXERCISE OF OPTION. The Option, or a portion thereof,
                  may be  exercised,  to the  extent it has  become  exercisable
                  pursuant to the terms of these Agreement Terms, by delivery of
                  written notice to Epitope in the form attached  hereto stating
                  the number of Shares,  form of payment,  and proposed  date of
                  closing.

         6.2               OTHER DOCUMENTS.  Participant  shall furnish Epitope,
                  before  closing  of any  exercise  of the  Option,  such other
                  documents or  representations as Epitope may require to assure
                  compliance with applicable laws and regulations.

         6.3               PAYMENT.  The exercise price for the Shares purchased
                  upon exercise of the Option shall be paid in full at or before
                  closing by one or a combination of the following:

                  (a) Payment in cash;

                  (b) By delivery (in a form  approved by the  Committee)  of an
                  irrevocable direction to a securities broker acceptable to the
                  Committee:

                           (i) To  sell  Shares  subject  to the  Option  and to
                           deliver  all  or a  part  of the  sales  proceeds  to
                           Epitope in  payment of all or a part of the  exercise
                           price and withholding taxes due; or

                           (ii) To pledge  Shares  subject  to the Option to the
                           broker as security for a loan and to deliver all or a
                           part of the loan  proceeds  to  Epitope in payment of
                           all or a part of the exercise  price and  withholding
                           taxes due; or

                  (c)  Delivery  of  previously  acquired  Shares  having a Fair
                  Market Value at least equal to the exercise price.


                                      - 4 -
<PAGE>


         6.4               PREVIOUSLY  ACQUIRED  SHARES.  Delivery of previously
                  acquired Shares  surrendered in full or partial payment of the
                  exercise price of the Option, or any portion thereof, shall be
                  subject to the following conditions:

                  (a) The Shares tendered shall be in good delivery form;

                  (b) The Fair  Market  Value of the Shares,  together  with the
                  amount of cash,  if any,  tendered  shall  equal or exceed the
                  exercise price of the Option;

                  (c) Any  Shares  remaining  after  satisfying  payment  of the
                  exercise  price  shall be  reissued  in the same manner as the
                  Shares tendered; and

                  (d) No  fractional  Shares will be issued and cash will not be
                  paid to Participant for any fractional Share value not used to
                  satisfy payment of the exercise price.

7                 TRANSFERABILITY.

         7.1               RESTRICTION.   Except  for  Permitted  Transfers,  as
                  defined in Section 7.2:

                  (a) The Option is not  transferable by Participant  other than
                  by testamentary  will or the laws of descent and  distribution
                  and, during Participant's  lifetime,  may be exercised only by
                  Participant or Participant's guardian or legal representative;

                  (b)  No  assignment   or  transfer  of  the  Option,   whether
                  voluntary,  involuntary,  or by operation of law or otherwise,
                  except  by  testamentary  will  or the  laws  of  descent  and
                  distribution,  shall vest in the  assignee or  transferee  any
                  interest or right; and

                  (c)  Immediately  upon any attempt to assign or  transfer  the
                  Option,  the  Option  shall  terminate  and be of no  force or
                  effect.

         7.2               PERMITTED TRANSFERS.  Participant may transfer all or
                  any portion of the Option,  without payment of  consideration,
                  to  Participant's  family  members,  trusts  for  such  family
                  members, or a partnership or limited liability


                                      - 5 -
<PAGE>


                  company of which  Participant  and  members  of  participant's
                  family are the only partners or members.

         7.3               EXERCISE  IN  THE  EVENT  OF  DEATH  OR   DISABILITY.
                  Whenever the word  "Participant"  is used in any  provision of
                  this Agreement under  circumstances  when the provision should
                  logically  be construed  to apply to  Participant's  guardian,
                  legal representative,  executor,  administrator, or the person
                  or  persons  to  whom  the  Option  may  be   transferred   by
                  testamentary  will or by the laws of descent and distribution,
                  the word "Participant"  shall be deemed to include such person
                  or persons.

8                 SECURITIES  LAWS.  Epitope shall not be required to distribute
         any Shares upon exercise of the Option,  or any portion thereof,  until
         Epitope  shall  have  taken any  action  required  to  comply  with the
         provisions of the Securities  Act of 1933 or any other then  applicable
         federal or state securities laws.

9                 TAX REIMBURSEMENT. In the event any withholding or similar tax
         liability is imposed on Epitope in  connection  with or with respect to
         the  exercise of the Option  governed by these  Agreement  Terms or the
         disposition by Participant of the Shares  acquired upon exercise of the
         Option,  Participant  agrees to pay to Epitope an amount  sufficient to
         satisfy such tax liability.

10                CONDITIONS  PRECEDENT.  Epitope  will use its best  efforts to
         obtain any  required  approvals of the Plan and the Option by any state
         or  federal   agency  or   authority   that  Epitope   determines   has
         jurisdiction.  If Epitope  determines that any required approval cannot
         be obtained,  all Awards to  Participant  shall  terminate on notice to
         Participant  to that effect  (provided  that nothing  contained in this
         Section 10 shall impair any rights Participant may have with respect to
         the  Option  pursuant  to  Participant's   employment   agreement  with
         Epitope).

11                TERMINATION FOR CAUSE; COMPETITION.

         11.1              ANNULMENT OF AWARDS. The grant of the Option governed
                  by these  Agreement  Terms is  provisional  until  Participant
                  becomes  entitled to a  certificate  for Shares in  settlement
                  thereof.  In  the  event  the  employment  of  Participant  is
                  terminated  for cause (as defined  below),  any portion of the
                  Option which is  provisional  shall be annulled as of the date
                  of such termination for cause. For the purpose of this Section
                  11.1, the term "for


                                      - 6 -
<PAGE>



                  cause"  shall  have the  meaning  set  forth in  Participant's
                  employment agreement with Epitope.

         11.2              ENGAGING IN COMPETITION WITH EPITOPE.  If Participant
                  terminates  employment  with Epitope or a  Subsidiary  for any
                  reason whatsoever, and within 12 months after the date thereof
                  accepts  employment  with  any  competitor  of  (or  otherwise
                  engages in competition  with) Epitope,  the Committee,  in its
                  sole discretion,  may require Participant to return to Epitope
                  the  economic  value of any Award that is realized or obtained
                  (measured at the date of exercise) by  Participant at any time
                  during  the  period  beginning  on the date that is six months
                  prior to the date of  Participant's  termination of employment
                  with Epitope.

12                SUCCESSORSHIP.  Subject to the restrictions on transferability
         of the Option set forth in these Agreement Terms and in the Plan, these
         Agreement  Terms shall be binding upon and benefit the  parties,  their
         successors, and assigns.

13                DEFINED  TERMS.  When  used  in  these  Agreement  Terms,  the
         following terms shall have the meanings specified below:

         13.1              "ACQUIRING  PERSON"  shall mean any person or related
                  person or  related  persons  which  constitute  a "group"  for
                  purposes of Section 13(d) and Rule 13d-5 under the  Securities
                  Exchange Act of 1934 (the "Exchange Act"), as such Section and
                  Rule are in effect as of the date of the Agreement;  provided,
                  however, that the term Acquiring Person shall not include:

                  (a) Epitope or any of its Subsidiaries;

                  (b)  Any  employee  benefit  plan  of  Epitope  or  any of its
                  Subsidiaries;

                  (c) Any entity  holding voting capital stock of Epitope for or
                  pursuant to the terms of any such employee benefit plan, or

                  (d) Any person or group  solely  because  such person or group
                  has  voting  power with  respect  to capital  stock of Epitope
                  arising from a revocable proxy or consent given


                                      - 7 -
<PAGE>


                  in response to a public proxy or consent solicitation made
                  pursuant to the Exchange Act.

         13.2              "AGREEMENT"  shall mean the  agreement  evidencing an
                  Option governed by these Agreement Terms.

         13.3              "CHANGE IN CONTROL" shall mean:

                  (a) A change in control  of Epitope of a nature  that would be
                  required  to be  reported in response to Item 6(e) of Schedule
                  14A  of  Regulation  14A  as in  effect  on  the  date  of the
                  Agreement pursuant to the Exchange Act; provided that, without
                  limitation,  such a change in control  shall be deemed to have
                  occurred  at  such  time  as any  Acquiring  Person  hereafter
                  becomes the "beneficial owner" (as defined in Rule 13d-3 under
                  the Exchange Act),  directly or  indirectly,  of 30 percent or
                  more of the combined voting power of Voting Securities; or

                  (b)  During  any  period of 12  consecutive  calendar  months,
                  individuals who at the beginning of such period constitute the
                  board of directors cease for any reason to constitute at least
                  a majority thereof unless the election,  or the nomination for
                  election,  by Epitope's  shareholders of each new director was
                  approved  by a vote of at least a  majority  of the  directors
                  then still in office who were  directors  at the  beginning of
                  the period; or

                  (c) There shall be consummated (i) any consolidation or merger
                  of Epitope in which Epitope is not the continuing or surviving
                  corporation  or pursuant to which Voting  Securities  would be
                  converted into cash, securities, or other property, other than
                  a merger of Epitope in which the holders of Voting  Securities
                  immediately   prior  to  the   merger   have  the   same,   or
                  substantially  the  same,  proportionate  ownership  of common
                  stock  of the  surviving  corporation  immediately  after  the
                  merger, or (ii) any sale, lease,  exchange,  or other transfer
                  (in one  transaction or a series of related  transactions)  of
                  all, or substantially all, of the assets of Epitope; or

                  (d)      Approval by the shareholders of Epitope of any
                  plan or proposal for the liquidation or dissolution of
                  Epitope.


                                      - 8 -
<PAGE>


         13.4     "CHANGE IN CONTROL  DATE" shall mean the first date  following
                  the date of the  Agreement  on which a Change in  Control  has
                  occurred.

         13.5     "GRANT  DATE"  means the date of the  Agreement,  which is the
                  date the Option is granted to Participant.

         13.6     "OPTION"  means  the  Nonqualified  Stock  Option  granted  to
                  Participant evidenced by the Agreement.

         13.7     "VOTING   SECURITIES"   shall   mean   Epitope's   issued  and
                  outstanding  securities ordinarily having the right to vote at
                  elections for Epitope's board of directors.

         13.8     Capitalized  terms not  otherwise  defined in these  Agreement
                  Terms have the meanings given them in the Plan.

14                NOTICES.  Any notices regarding the Option shall be in writing
         and  shall be  effective  when  actually  delivered  personally  or, if
         mailed,  when deposited as registered or certified mail directed to the
         address  maintained in Epitope's  records or to such other address as a
         party may certify by notice to the other party.



                                      - 9 -
<PAGE>
                     EARLY EXERCISE STOCK PURCHASE AGREEMENT

                  THIS AGREEMENT is made by and between EPITOPE, INC., an Oregon
corporation ("Epitope"), and ---------------------------- ("Purchaser").

                                    RECITALS

                  A.  Purchaser  holds a stock option (the "Option") to purchase
shares of Epitope's  common stock  ("Shares")  pursuant to Epitope's  1991 Stock
Award Plan (the "Plan") which Purchaser desires to exercise; and

                  B.  Purchaser  wishes to take  advantage of the early exercise
provision of the Option and therefore to enter into this Agreement.

                                    AGREEMENT

                  1. (a) Pursuant to an early exercise of the Option,  Purchaser
agrees to  purchase  from  Epitope,  and  Epitope  agrees to sell to  Purchaser,
- -------------- Shares for an exercise price of $------ per Share (total exercise
price: $---------) payable as follows:

                        Cash at Closing                   $------

                        Value of Previously
                         Owned Shares1                    $------

                        Total Exercise Price              $------

                  (b) The  closing  shall occur at the offices of Epitope on the
date of this  Agreement  or at such  other  time and  place as the  parties  may
mutually agree upon in writing.

                  (c) At the closing, Purchaser shall deliver to Epitope a stock
assignment  in the form of  Exhibit  B, duly  endorsed  (with date and number of
shares left blank) and the total exercise price (including endorsed certificates
representing the appropriate  number of previously owned Shares tendered for all
or a portion of the total exercise price).

                  (d) At the closing or as soon thereafter as practical, Epitope
shall cause share  certificates for all the Shares that are to be subject to the
Purchase  Option (as  defined  in  Section 2 below) to be issued in  Purchaser's
name, and Epitope shall retain those certificates, together with the blank stock
assignments until the Purchase Option is exercised or expires

- ----------------

         1  Shares  tendered  as  part  of the  exercise  price  must  meet  the
requirements of the Option and the Plan.


                                      - 1 -
<PAGE>


pursuant to this  Agreement,  and shall deliver share  certificates to Purchaser
for all the Shares, if any, that are not to be subject to the Purchase Option.

                  2. The Shares to be purchased  by  Purchaser  pursuant to this
Agreement shall be subject to the following option ("Purchase Option"):

                  (a) In the event that  Purchaser  ceases to be an  employee of
         Epitope and/or any of its  subsidiaries  (an "Employer") for any reason
         (including Purchaser's death), or no reason, with or without cause, the
         Purchase  Option may be exercised.  Epitope shall have the right at any
         time  within  the  90-day  period  after  Purchaser's   termination  of
         Employment  (as defined in the Agreement  Terms for the Option) with an
         Employer  or such  longer  period as may be agreed  to by  Epitope  and
         Purchaser (for example,  for purposes of satisfying the requirements of
         Section  1202(c)(3)  of the  Internal  Revenue  Code) to purchase  from
         Purchaser  or his personal  representative,  as the case may be, at the
         price per Share paid by Purchaser  pursuant to this Agreement  ("Option
         Price"),  up to but not  exceeding  the  number of Shares  set forth on
         Exhibit  A to this  Agreement  which  is  incorporated  herein  by this
         reference.

                  (b) The  Purchase  Option  shall  lapse  at the  same  rate as
         Purchaser's  Option  would have vested had  Purchaser  not entered into
         this Agreement (e.g., vesting shall accelerate upon a Change in Control
         Date).

                  (c) This  Agreement is not an employment  contract and nothing
         in this  Agreement  shall be deemed to create in any way whatsoever any
         obligation  on the part of  Purchaser  to  continue  in the  employ  of
         Epitope,  or of  Epitope  to  continue  Purchaser  in the  employ of an
         Employer.

                  3. The  Purchase  Option may be  exercised  by giving  written
notice of  exercise  delivered  or  mailed  as  provided  in  paragraph  9. Upon
providing  of such notice and payment or tender of the purchase  price,  Epitope
shall become the legal and  beneficial  owner of the Shares being  purchased and
all rights and interests therein or related thereto.

                  4. If from time to time during the term of the Purchase Option
there is any stock  dividend or  liquidating  dividend or  distribution  of cash
and/or  property,  stock split or other change in the character or amount of any
of the outstanding  securities of Epitope, then, in such event, any and all new,
substituted  or additional  securities or other  property to which  Purchaser is
entitled by reason of his ownership of Shares will be immediately subject to the
Purchase  Option and be included in the word  "Shares"  for all  purposes of the
Purchase Option with the same force and effect as the Shares then subject to the
Purchase  Option.  While the total Option Price shall remain the same after each
such event,  the Option  Price per Share upon  exercise of the  Purchase  Option
shall be appropriately adjusted.


                                      - 2 -
<PAGE>


                  5.  Purchaser  may not  sell  or  transfer  any of the  Shares
subject to the Purchase  Option or any  interest  therein so long as such Shares
are subject to the Purchase Option.

                  6. Epitope  shall not be required (i) to transfer on its books
any Shares which shall have been sold or  transferred in violation of any of the
provisions  set forth in this Agreement or (ii) to treat as owner of such Shares
or to  accord  the  right  to vote  as such  owner  or to pay  dividends  to any
transferee to whom such Shares shall have been so transferred.

                  7.  Subject to the  provisions  of  paragraphs  5 and 6 above,
Purchaser  (but not any  unapproved  transferee)  may,  during  the term of this
Agreement,  exercise all rights and  privileges of a shareholder of Epitope with
respect to the Shares.

                  8. The parties agree to execute such further  instruments  and
to take such  further  action as  reasonably  may be  necessary to carry out the
intent of this Agreement.

                  9. Any notice  required or permitted  hereunder shall be given
in writing and shall be deemed  effectively given upon personal delivery or upon
deposit in any United States Post Office Box, by  registered  or certified  mail
with  postage  and fees  prepaid,  addressed  to the other  party  hereto at his
address  hereinafter  shown below his signature or at such other address as such
party may designate by ten (10) days' advance  written notice to the other party
hereto.

                  10. This Agreement  shall bind and inure to the benefit of the
successors and assigns of Epitope and,  subject to the  restrictions on transfer
herein set forth,  inure to the benefit of and be binding  upon  Purchaser,  his
heirs, executors, administrators,  successors, and assigns. Without limiting the
generality of the foregoing,  the Purchase Option of Epitope  hereunder shall be
assignable by Epitope at any time or from time to time, in whole or in part.

                  IN WITNESS  WHEREOF,  the parties  hereto have  executed  this
Agreement as of the --- day of --------------, 19----.

                                  EPITOPE, INC.

                                  By -------------------------------------------

                                  Address:     8505 S.W. Creekside Place
                                               Beaverton, Oregon  97008


                                  ----------------------------------------------
                                  Purchaser

                                  Address: -------------------------------------


                                      - 3 -
<PAGE>


                                  ----------------------------------------------



ATTACHMENTS:

Exhibit A         Vesting Schedule
Exhibit B         Assignment Separate from Certificate



                                      - 4 -
<PAGE>


                                    EXHIBIT A

                                VESTING SCHEDULE

                                          Number of Shares
                                             Subject to
If Cessation of Employment Occurs:        Purchase Option
- ----------------------------------        ----------------





<PAGE>


                                    EXHIBIT B

                      ASSIGNMENT SEPARATE FROM CERTIFICATE


                  FOR VALUE RECEIVED and pursuant to that certain Early Exercise
Stock Purchase  Agreement  between the undersigned and Epitope,  Inc., an Oregon
corporation ("Epitope") dated as of ---------------, 1997 (the "Agreement"), the
undersigned    hereby    sells,    assigns   and    transfers    unto    Epitope
- ----------------------------   (------)  shares  of  common  stock  of  Epitope,
standing  in the  undersigned's  name on the  books of  Epitope  represented  by
Certificate  No. ------  herewith,  and does hereby  irrevocably  constitute and
appoint  ----------------  attorney to  transfer  the said stock on the books of
Epitope with full power of substitution in the premises.  This Assignment may be
used only in  accordance  with and  subject to the terms and  conditions  of the
Agreement, in connection with the repurchase of shares of Common Stock issued to
the  undersigned  pursuant  to the  Agreement  and only to the extent  that such
shares remain subject to Epitope's Purchase Option under the Agreement.

Dated: ----------------------------



                                   ---------------------------------------------
                                   [Signature]



                                   ---------------------------------------------
                                   [Print Name]

[INSTRUCTION:  Please do not fill in any blanks other than the  signature  line.
The purpose of this  Assignment is to enable  Epitope to exercise its repurchase
option set forth in the Agreement without requiring additional signatures on the
part of Purchaser.]


                              EMPLOYMENT AGREEMENT


                  This  Employment  Agreement is entered into as of December --,
1997,  between  Charles E. Bergeron  ("Employee")  and Epitope,  Inc., an Oregon
corporation (the "Company").

                  1. SERVICES.

                           1.1  EMPLOYMENT.  Effective  upon Gilbert N. Miller's
resignation  as Chief  Financial  Officer of the Company,  the Company agrees to
employ  Employee as Chief  Financial  Officer of the  Company.  Until such time,
Company  agrees  to employ  employee  as Vice  President  of  Operations  of the
Company.  Employee  hereby accepts such  employment in accordance with the terms
and conditions of this  Agreement.  Employment  shall continue until  terminated
pursuant to the terms of this Agreement.

                           1.2 DUTIES. Employee shall have the position named in
Section  1.1 with such  powers and duties  appropriate  to that office as may be
provided by the bylaws of the Company and as determined from time to time by the
President and Chief Executive  Officer or the board of directors of the Company.
Subject to the provisions of Section 7.4,  Employee's position and duties may be
changed  from time to time  during the term of this  Agreement,  and  Employee's
place of work may be relocated at the sole discretion of the President and Chief
Executive Officer or the board of directors.

                           1.3 OUTSIDE  ACTIVITIES.  Employee  shall  obtain the
consent of the President and Chief  Executive  Officer or the board of directors
before he engages,  either directly or indirectly,  in any other professional or
business  activities that may require an appreciable  portion of Employee's time
or effort to the detriment of the Company's business.

                           1.4  DIRECTION  OF  SERVICES.  Employee  shall at all
times  discharge his duties in  consultation  with and under the supervision and
direction of the President and Chief Executive Officer of the Company.

                  2. COMPENSATION AND EXPENSES.

                           2.1 SALARY.  As compensation  for services under this
Agreement, the Company shall pay to Employee a regular salary established by the
President and Chief Executive Officer or the board of directors. Such salary may
be  adjusted  from time to time in the  discretion  of the  President  and Chief
Executive  Officer  or the  board  of  directors.  Payment  shall  be  made on a
bi-weekly  basis,  less all amounts required by law or authorized by Employee to
be withheld or deducted, at such times as shall be determined by the Company.

                           2.2  ADDITIONAL  EMPLOYEE  BENEFITS.  To  the  extent
otherwise eligible, Employee shall also be entitled to receive or participate in
any additional benefits, including without limitation insurance programs, profit
sharing or pension plans, and medical  reimbursement  plans, which may from time
to time be made available by the Company to


                                      - 1 -
<PAGE>



corporate  officers.  The Company may change or discontinue such benefits at any
time in its sole discretion.

                           2.3 EXPENSES.  The Company shall  reimburse  Employee
for all  reasonable and necessary  expenses  incurred in carrying out his duties
under this Agreement. Employee shall present to the Company from time to time an
itemized  account  of such  expenses  in such  form  as may be  required  by the
Company.

                           2.4 FEES. All compensation earned by Employee,  other
than pursuant to this Agreement,  as a result of services performed on behalf of
the Company or as a result of or arising out of any work done by Employee in any
way related to the scientific or business activities of the Company shall belong
to the Company.  Employee shall pay or deliver such  compensation to the Company
promptly upon receipt. For the purposes of this provision,  "compensation" shall
include,  but is not  limited to, all  professional  and  nonprofessional  fees,
lecture fees, expert testimony fees, publishing fees, royalties, and any related
income,  earnings,  or other  things  of  value;  and  "scientific  or  business
activities of the Company" shall include,  but not be limited to, any project or
projects  in which the  Company  is  involved  and any  subject  matter  that is
directly or indirectly researched,  tested, developed,  promoted, or marketed by
the Company.

                  3. STOCK  OPTIONS.  The Company shall grant Employee an option
to purchase  30,000  shares of common stock of the Company at an exercise  price
equal to the fair market value of the stock on the date of grant.

                  4. CONFIDENTIAL INFORMATION.

                           4.1  DEFINED.   "Confidential   Information"  is  all
nonpublic  information relating to the Company or its business that is disclosed
to Employee,  that Employee produces,  or that Employee otherwise obtains during
employment.  "Confidential  Information" also includes information received from
third parties that the Company has agreed to treat as confidential.  Examples of
Confidential Information are:

                           4.1.1 Marketing plans.

                           4.1.2 Customer lists.

                           4.1.3 Product design and manufacturing information.

                           4.1.4 Financial information.

                           4.2 ACCESS TO INFORMATION. Employee acknowledges that
in the course of his employment he will have access to Confidential Information,
that  such  information  is a  valuable  asset  of the  Company,  and  that  its
disclosure or unauthorized use will cause the Company substantial harm.


                                      - 2 -
<PAGE>



                           4.3  OWNERSHIP.   Employee   acknowledges   that  all
Confidential  Information  shall  continue to be the  exclusive  property of the
Company (or the third party that  disclosed it to the  Company),  whether or not
prepared  in  whole or in part by  Employee  and  whether  or not  disclosed  to
Employee or entrusted to his custody in  connection  with his  employment by the
Company.

                           4.4  NONDISCLOSURE  AND NONUSE.  Unless authorized or
instructed  in writing  by the  Company,  or  required  by  legally  constituted
authority,  Employee will not, except as required in the course of the Company's
business,  during  or  after  his  employment,  disclose  to  others  or use any
Confidential  Information,  unless and until,  and then only to the extent that,
such items become available to the public through no fault of Employee.

                           4.5 RETURN OF CONFIDENTIAL INFORMATION.  Upon request
by the  Company  during  or after  his  employment,  and  without  request  upon
termination  of  employment  pursuant to this  Agreement,  Employee will deliver
immediately  to  the  Company  all  written  or  tangible  materials  containing
Confidential Information without retaining any excerpts or copies.

                           4.6  DURATION.  The  obligations  set  forth  in this
Section 4 will continue beyond the term of employment of Employee by the Company
and for so long as Employee possesses Confidential Information.

                  5. MATERIALS  PREPARED AND INVENTIONS MADE DURING  EMPLOYMENT.
The  Company  shall be the  exclusive  owner  of all  materials,  concepts,  and
inventions Employee prepares,  develops, or makes (whether alone or jointly with
others) within the scope of his employment, and of all related rights (including
copyrights,   trademarks,   and  patents)  and  proceeds.   Without  limitation,
materials, concepts, and inventions that (a) relate to the Company's business or
actual or demonstrably  anticipated research or development,  or (b) result from
any work performed by Employee for the Company,  shall be considered  within the
scope of  Employee's  employment.  Employee  shall  promptly  disclose  all such
materials,  concepts,  and  inventions to the Company.  Employee  shall take all
action reasonably  requested by the Company to vest ownership of such materials,
consents,  and  inventions  in the  Company  and to permit the Company to obtain
copyright, trademark, patent, or similar protection in its name.

                  6.   NONCOMPETITION.   Employee  confirms  the  noncompetition
covenant set forth in his Employment  Agreement dated as of August 31, 1993 (the
"1993  Agreement").  The covenant is restated below to refer to the  appropriate
sections of this Agreement.

                           6.1  COVENANT.  Subject to the  provisions of Section
6.3,  Employee  covenants that Employee will not,  throughout the United States,
either  individually  or  as a  director,  officer,  partner,  employee,  agent,
representative,  or consultant with any business,  directly or indirectly during
the term of employment and for one year thereafter:

                                    6.1.1  Engage  or  prepare  to engage in any
business that competes with the Company;


                                      - 3 -
<PAGE>


                                    6.1.2 Induce or attempt to induce any person
who is an employee of the Company  during the term of this covenant to leave the
employ of the Company; or

                                    6.1.3 Solicit,  divert, or accept orders for
products or services  that are  substantially  competitive  with the products or
services sold by the Company from any customer of the Company.

                           6.2  ENFORCEMENT.  Employee  acknowledges  and agrees
that  the  time,  scope,  and  other  provisions  of this  Section  6 have  been
specifically   negotiated   by   sophisticated   parties  with  the  advice  and
consultation of counsel and  specifically  hereby agrees that such time,  scope,
and other  provisions are reasonable under the  circumstances.  Employee further
agrees  that if, at any time,  despite  the  express  agreement  of the  parties
hereto, a court of competent jurisdiction holds that any portion of this Section
6 is unenforceable for any reason, the maximum restrictions reasonable under the
circumstances,  as determined by such court,  will be  substituted  for any such
restrictions held unenforceable.

                           6.3  RELEASE  FROM  OBLIGATION.  In  the  event  that
Employee  shall  be  entitled  to  extraordinary  compensation  pursuant  to the
provisions of Section  7.5.2,  Employee may elect to waive all rights to receive
such  compensation  from and after the date of such waiver in  exchange  for the
release of  Employee  from the  obligations  of Sections  6.1.1 and 6.1.3.  Such
waiver  shall be in  writing,  shall state that it is in  consideration  for the
release of Employee  from the  obligations  of Sections  6.1.1 and 6.1.3 of this
Agreement,  and shall be effective  when  delivered to Epitope.  In the event of
such a waiver,  the amounts payable  pursuant to the provisions of Section 7.5.2
shall be prorated  through the period  commencing on the date of  termination of
employment and ending on the date of delivery of the written notice of waiver to
Epitope.  For  example,  if such waiver is delivered to Epitope six months after
the commencement for the  12-month-period  set forth in Section 7.5.2,  Employee
shall  be  paid  one-half  of the  amounts  otherwise  payable  pursuant  to the
provisions of Section 7.5.2; in the event that Employee shall have received more
than  such  pro rata  share of such  compensation,  it shall be a  condition  of
Employee's  rights under this section that he shall have returned to Epitope any
amounts in excess of such pro rata share with the delivery of the waiver  notice
to Epitope.

                  7. TERMINATION.

                           7.1  TERMINATION  UPON DEATH.  This  Agreement  shall
terminate immediately upon Employee's death.

                           7.2  TERMINATION BY EMPLOYEE.  Employee may terminate
his employment under this Agreement by 90 days' written notice to the Company.

                           7.3 TERMINATION BY THE COMPANY FOR CAUSE. The Company
may terminate Employee's  employment under this Agreement for cause at any time,
with or without advance notice.  "Cause" includes,  but is not limited to: (a) a
material breach of this Agreement by Employee and Employee's failure to promptly
cure such breach after receipt of written  notice thereof from the President and
Chief Executive Officer or the board of directors of the


                                      - 4 -
<PAGE>


Company; (b) Employee's willful refusal or failure, or Employee's inability,  to
comply  with any  policies  or  standards  of the  Company or to perform any job
duties of Employee; (c) any act of fraud, dishonesty,  or misconduct by Employee
in connection with Employee's employment with the Company; (d) the commission of
any  act in  direct  competition  with or  materially  detrimental  to the  best
interests of the Company; or (e) Employee's failure to otherwise comply with the
standards  of behavior  that an employer has the right to expect of an employee.
The Company  reserves the right to determine  the facts giving rise to cause for
termination and whether those facts constitute cause for termination.

                           7.4  TERMINATION BY THE COMPANY  WITHOUT  CAUSE.  The
Company may terminate  Employee's  employment under this Agreement without cause
by written notice to Employee. Employee may (but shall not be required to) elect
to treat either of the following events as a termination without cause, provided
Employee acts within 60 days of the event:

                                    7.4.1 A  relocation  by the  Company  of the
principal place where  Employee's  duties are to be performed to a place outside
of the Portland metropolitan area.

                                    7.4.2 A "Change of Control" of the  Company.
For  purposes of this  Agreement,  a "Change of Control"  shall mean a change of
control of a nature  that would be  required  to be reported in response to Item
6(e) of Schedule 14A of Regulation 14A as in effect on the date hereof  pursuant
to the  Securities  Exchange Act of 1934 (the  "Exchange  Act");  provided that,
without limitation, such a change of control shall be deemed to have occurred at
such time as (i) any Acquiring Person hereafter  becomes the "beneficial  owner"
(as defined in Rule 13d-3 under the Exchange Act), directly or indirectly, of 30
percent or more of the combined voting power of Voting  Securities;  (ii) during
any period of 12 consecutive  calendar months,  individuals who at the beginning
of such  period  constitute  the  board of  directors  cease  for any  reason to
constitute at least a majority  thereof  unless the election,  or the nomination
for election, by the Company's shareholders of each new director was approved by
a vote of at least a  majority  of the  directors  then still in office who were
directors at the beginning of the period;  (iii) there shall be consummated  (a)
any  consolidation  or merger of the  Company  in which the  Company  is not the
continuing or surviving corporation or pursuant to which Voting Securities would
be converted into cash,  securities,  or other property,  other than a merger of
the Company in which the holders of Voting  Securities  immediately prior to the
merger have the same,  or  substantially  the same,  proportionate  ownership of
common stock of the surviving  corporation  immediately after the merger, or (b)
any sale, lease,  exchange, or other transfer (in one transaction or a series of
related  transactions)  of all,  or  substantially  all,  of the  assets  of the
Company;  or (iv)  approval  by the  shareholders  of the Company of any plan or
proposal for the liquidation or dissolution of the Company. For purposes of this
Agreement,  "Acquiring  Person"  means  any  person  or  related  persons  which
constitute  a "group"  for  purposes  of Section  13(d) and Rule 13d-5 under the
Exchange  Act,  as such  Section  and Rule are in  effect as of the date of this
Agreement;  provided, however, that the term Acquiring Person shall not include:
(i) the Company or any of its  subsidiaries;  (ii) any employee  benefit plan of
the Company or any of its subsidiaries;  (iii) any entity holding voting capital
stock of the Company for or pursuant to the terms of any such  employee  benefit
plan; or (iv) any person or group solely because such person or group has voting
power with respect to capital stock of the Company arising from a


                                      - 5 -
<PAGE>


revocable  proxy or  consent  given in  response  to a public  proxy or  consent
solicitation  made pursuant to the Exchange Act. For purposes of this Agreement,
"Voting  Securities"  means the  Company's  issued  and  outstanding  securities
ordinarily  having the right to vote at  elections  for the  Company's  board of
directors.

                           7.5 COMPENSATION UPON TERMINATION.

                                    7.5.1 TERMINATION UNDER SECTION 7.1, 7.2, OR
7.3. In the event of a termination of Employee's  employment  under Section 7.1,
7.2, or 7.3,  Employee's regular  compensation  pursuant to Section 2.1 shall be
prorated and payable until the date of termination.

                                    7.5.2  TERMINATION UNDER SECTION 7.4. In the
event of a termination of Employee's  employment by the Company without cause as
provided in Section 7.4,  Employee shall continue to be paid the salary provided
in  Section  2.1 for 12 months  from the date of notice of such  termination  of
employment,  in the manner and at the times at which  regular  compensation  was
paid to Employee during the term of his employment under this Agreement,  except
that if Employee  elects to treat an event  described in Sections 7.4.1 or 7.4.2
as a  termination  without cause but continues to work for the Company or any of
its subsidiaries,  then any amounts Employee receives as compensation during the
12-month period shall be credited  against the amounts payable to Employee under
this section.  Unless Employee elects to continue working for the Company or any
of its subsidiaries,  as a condition to receipt of the compensation described in
the preceding sentence Employee shall sign,  deliver,  and abide by a Separation
Agreement and Release,  substantially  in the form attached as Exhibit A to this
Agreement.  The Company's  obligation to pay the amounts  stated in this section
shall  terminate  if Employee  engages,  either  individually  or as a director,
officer,  partner,  employee,  agent,  representative,  or  consultant  with any
business,  directly or  indirectly  in any of the  activities  listed in Section
6.1.1,  6.1.2,  or 6.1.3  anywhere  in the United  States  within one year after
termination of employment.

                  8. REMEDIES.  The respective  rights and duties of the Company
and Employee  under this Agreement are in addition to, and not in lieu of, those
rights  and  duties  afforded  to and  imposed  upon  them by law or at  equity.
Employee  acknowledges  that breach of Sections 4 and 6 of this  Agreement  will
cause  irreparable  harm to the  Company  and agrees to the entry of a temporary
restraining   order  and   permanent   injunction  by  any  court  of  competent
jurisdiction to prevent breach or further breach of this Agreement.  Such remedy
shall be in addition to any other  remedy  available to the Company at law or in
equity.

                  9.   SEVERABILITY  OF  PROVISIONS.   The  provisions  of  this
Agreement  are  severable,  and if any  provision  hereof  is  held  invalid  or
unenforceable,  it shall be enforced to the maximum extent permissible,  and the
remaining provisions of the Agreement shall continue in full force and effect.

                  10.  ATTORNEY  FEES. In the event a suit or action is filed to
enforce  Sections  4 or 6 of this  Agreement,  the  prevailing  party  shall  be
reimbursed by the other party for all costs


                                      - 6 -
<PAGE>


and expenses  incurred in connection with the suit or action,  including without
limitation reasonable attorney fees at trial or on appeal.

                  11.  NONWAIVER.  Failure of the Company at any time to require
performance of any provision of this Agreement  shall not limit the right of the
Company to enforce the  provision.  No  provision  of this  Agreement  or breach
thereof may be waived by either party except by a writing  signed by that party.
A waiver of any  breach of a  provision  of this  Agreement  shall be  construed
narrowly and shall not be deemed to be a waiver of any succeeding breach of that
provision or a waiver of that provision itself or of any other provision.

                  12.      ARBITRATION.

                           12.1  CLAIMS  COVERED.  All claims or  controversies,
except for those excluded by Section 12.2 ("claims"), whether or not arising out
of Employee's employment (or its termination), that the Company may have against
Employee or that  Employee may have against the Company or against its officers,
directors, employees or agents, in their capacity as such or otherwise, shall be
resolved as  provided in this  Section  12.  Claims  covered by this  Section 12
include,  but are not limited to,  claims for wages or other  compensation  due;
claims for breach of any contract or covenant (express or implied); tort claims;
claims for  discrimination  (including,  but not limited to, race,  sex,  sexual
orientation,  religion,  national origin,  age, marital status,  or disability);
claims for benefits  (except where an employee benefit or pension plan specifies
that its claims procedure shall culminate in an arbitration  procedure different
from this  one),  and claims  for  violation  of any  federal,  state,  or other
governmental  law,  statute,  regulation,  or  ordinance,  except as provided in
Section 12.2.

                           12.2  NON-COVERED  CLAIMS.   Claims  arising  out  of
Sections 4 and 6 of this  Agreement and workers'  compensation  or  unemployment
compensation  benefits  are not covered by this Section 12.  Non-covered  claims
include but are not limited to claims by the Company for injunctive and/or other
equitable  relief for  unfair  competition  and/or  the use and/or  unauthorized
disclosure of trade secrets or  confidential  information,  as to which Employee
understands  and agrees that the Company may seek and obtain relief from a court
of competent jurisdiction.

                           12.3  REQUIRED  NOTICE OF ALL CLAIMS  AND  STATUTE OF
LIMITATIONS.  Company  and  Employee  agree that the  aggrieved  party must give
written  notice of any claim to the other party  within one year of the date the
aggrieved  party  first has  knowledge  of the event  giving  rise to the claim;
otherwise  the claim shall be void and deemed  waived even if there is a federal
or state statute of  limitations  which would have given more time to pursue the
claim.  The written  notice shall identify and describe the nature of all claims
asserted and the facts upon which such claims are based.

                           12.4 HEARING OR MEDIATION.  Prior to any  arbitration
proceeding  taking place  pursuant to this section,  Company or Employee may, at
its respective option, elect to submit the claim to non-binding mediation before
a mutually agreeable mediation tribunal or


                                      - 7 -
<PAGE>



mediator,  in which event both parties shall execute a suitable  confidentiality
agreement and abide by the  procedures  specified by the  mediation  tribunal or
mediator.

                           12.5 ARBITRATION PROCEDURES. Any arbitration shall be
conducted in  accordance  with the  then-current  Model  Employment  Arbitration
Procedures  of  the  American  Arbitration  Association  ("AAA"),   modified  to
substitute for AAA actions,  the United States Arbitration and Mediation Service
("USA&MS"), before an arbitrator who is licensed to practice law in the state of
Oregon (the "Arbitrator"). The arbitration shall take place in or near Portland,
Oregon.

                                    12.5.1  SELECTION OF ARBITRATOR.  The USA&MS
shall  give  each  party  a list of 11  arbitrators  drawn  from  its  panel  of
labor-management  dispute  arbitrators.  Each  party may strike all names on the
list it deems unacceptable.  If only one common name remains on the lists of all
parties, that individual shall be designated as the Arbitrator. If more than one
common name remains on the lists of all parties,  the parties shall strike names
alternately  until only one  remains.  The party who did not  initiate the claim
shall strike first.  If no common name remains on the lists of all parties,  the
USA&MS  shall  furnish  an  additional  list or  lists  until an  Arbitrator  is
selected.

                                    12.5.2  APPLICABLE LAW. The Arbitrator shall
apply the substantive law (and the law of remedies,  if applicable) specified in
this Agreement or federal law, or both, as applicable to the claim(s)  asserted.
The Oregon Rules of Evidence shall apply.  The Arbitrator,  and not any federal,
state, or local court or agency,  shall have exclusive  authority to resolve any
dispute  relating  to  the  interpretation,   applicability,  enforceability  or
formation of this Agreement,  including but not limited to any claim that all or
any part of this Agreement is void or voidable.  The arbitration  shall be final
and binding upon the parties, except as provided in this Agreement.

                                    12.5.3 AUTHORITY.  The Arbitrator shall have
jurisdiction to hear and rule on pre-hearing  disputes and is authorized to hold
pre-hearing  conferences  by  telephone  or in  person as the  Arbitrator  deems
necessary.  The  Arbitrator  shall have the  authority  to entertain a motion to
dismiss  and/or a motion for  summary  judgment by any party and shall apply the
standards governing such motions under the Federal Rules of Civil Procedure. The
Arbitrator  shall render an award and opinion in the form typically  rendered in
labor arbitrations.

                                    12.5.4  REPRESENTATION.  Any  party  may  be
represented by an attorney or other representative selected by the party.

                                    12.5.5 DISCOVERY.  Each party shall have the
right to take the deposition of one individual and any expert witness designated
by another  party.  Each party  also shall have the right to make  requests  for
production of documents to any party.  The subpoena right  specified below shall
be applicable to discovery pursuant to this paragraph.  Additional discovery may
be had only where the Arbitrator  selected pursuant to this Agreement so orders,
upon a showing of substantial need. At least 30 days before the arbitration, the


                                      - 8 -
<PAGE>


parties must exchange lists of witnesses,  including any experts,  and copies of
all exhibits  intended to be used at the arbitration.  Each party shall have the
right to subpoena witnesses and documents for the arbitration.

                                    12.5.6   REPORTER.   Either  party,  at  its
expense,  may  arrange  for and pay the cost of a court  reporter  to  provide a
stenographic record of proceedings.

                                    12.5.7  POST-HEARING  BRIEFS.  Either party,
upon  request  at  the  close  of  hearing,  shall  be  given  leave  to  file a
post-hearing  brief.  The  time  for  filing  such a brief  shall  be set by the
Arbitrator.

                           12.6 ENFORCEMENT. Either party may bring an action in
any court of competent  jurisdiction to compel  arbitration under this Agreement
and to  enforce an  arbitration  award.  Except as  otherwise  provided  in this
Agreement,  both the Company and Employee  agree that neither shall  initiate or
prosecute any lawsuit (other than for a non-covered claim) in any way related to
any claim covered by this  Agreement.  A party opposing  enforcement of an award
may not do so in an enforcement proceeding,  but must bring a separate action in
any court of competent  jurisdiction to set aside the award,  where the standard
of review will be the same as that  applied by an  appellate  court  reviewing a
decision of a trial court sitting without a jury.

                           12.7 ARBITRATION FEES AND COSTS. Company and Employee
shall  equally  share  the fees and costs of the  Arbitrator.  Each  party  will
deposit  funds  or  post  other  appropriate  security  for  its  share  of  the
Arbitrator's fee, in an amount and manner determined by the Arbitrator,  10 days
before  the first day of  hearing.  Each  party  shall pay for its own costs and
attorneys' fees, if any,  provided that the Arbitrator,  in its sole discretion,
may award reasonable fees to the prevailing party in a proceeding.

                  13. GENERAL TERMS AND CONDITIONS.  This Agreement  constitutes
the entire  understanding  of the parties relating to the employment of Employee
by the  Company,  and,  except as set forth in  Section  6 with  respect  to the
noncompetition  covenant in the 1993  Agreement,  supersedes  and  replaces  all
written  and oral  agreements  heretofore  made or  existing  by and between the
parties relating  thereto.  This Agreement shall be construed in accordance with
the laws of the state of Oregon,  without  regard to any conflicts of laws rules
thereof.  This Agreement shall inure to the benefit of any successors or assigns
of the Company.  All captions used herein are intended solely for convenience of
reference and shall in no way limit any of the provisions of this Agreement.


                                      - 9 -
<PAGE>



                  The parties have executed this Employment  Agreement as of the
date stated above.


                                            EPITOPE, INC.



                                            By:
CHARLES E. BERGERON
                                            Title:


                                     - 10 -
<PAGE>



                        EXHIBIT A TO EMPLOYMENT AGREEMENT

                        SEPARATION AGREEMENT AND RELEASE

         A. This  Separation  Agreement  and Release  ("Agreement")  is made and
entered  into as of this  ----- day of  --------------,  -----,  by and  between
Company,  Inc., an Oregon corporation  ("Company"),  and  ----------------------
("--------------")   in  order  to   provide   the  terms  and   conditions   of
- --------------'s  termination of employment, to fully and completely resolve any
and all issues that  --------------  may have in connection  with his employment
with Company or the termination of that  employment,  and to promote an amicable
long-term relationship between Company and --------------.

         B. In  consideration  of the mutual  promises and conditions  contained
herein, the parties agree as follows:

                  1. SEPARATION. -------------- has been [is currently] employed
at  Company  as  --------------.   --------------  shall  have  no  further  job
responsibilities  at Company after  --------------,  and his employment shall be
terminated effective as of such date.

                  2.  PAYMENT  TO  --------------.  Pursuant  to the  Employment
Agreement entered into between the parties, Company agrees to provide additional
compensation  to  --------------  in  the  amount  of  ---------------  provided
- -------------- executes and does not revoke this Agreement.

                  3. RELEASE OF CLAIMS. In return for the benefits  conferred by
this Agreement (and described in the Employment Agreement), which --------------
acknowledges  Company has no legal obligation to provide if --------------  does
not enter into this  Agreement,  --------------,  on behalf of  himself  and his
heirs,  executors,  administrators,  successors and assigns, hereby releases and
forever  discharges  Company  and  its  past,  present  and  future  affiliates,
subsidiaries,  predecessors,  successors  and  assigns,  and each of their past,
present and future  shareholders,  officers,  directors,  employees,  agents and
insurers,  from  any  and all  claims,  actions,  causes  of  action,  disputes,
liabilities  or damages,  of any kind,  which may now exist or hereafter  may be
discovered,  specifically  including,  but not  limited  to, any and all claims,
disputes,  actions,  causes of action,  liabilities or damages,  arising from or
relating to --------------'s employment with Company, or the termination of such
employment,  except for any claim for  payment or  performance  pursuant  to the
terms of this  Agreement.  This  release  includes,  but is not  limited to, any
claims that  --------------  might have for reemployment or reinstatement or for
additional  compensation  or  benefits  and applies to claims that he might have
under  either  federal,  state or local law dealing with  employment,  contract,
tort,  wage and hour, or civil rights  matters,  including,  but not limited to,
Title VII of the Civil Rights Act of 1964, the Age  Discrimination in Employment
Act, the  Americans  with  Disabilities  Act, the Family and Medical  Leave Act,
similar state laws, and any regulations  under such laws. This release shall not
affect any accrued rights  --------------  may have under any medical insurance,
workers' compensation or retirement plan because of his prior employment with


<PAGE>



Company.  -------------- ACKNOWLEDGES AND AGREES THAT THROUGH THIS RELEASE HE IS
GIVING UP ALL RIGHTS AND  CLAIMS OF EVERY KIND AND NATURE  WHATSOEVER,  KNOWN OR
UNKNOWN,  CONTINGENT  OR  LIQUIDATED,  THAT HE MAY HAVE AGAINST  Company AND THE
OTHER PERSONS NAMED ABOVE, EXCEPT FOR THE RIGHTS SPECIFICALLY EXCLUDED ABOVE.

                  4.   CONFIDENTIALITY.   --------------  agrees  to  keep  this
Agreement and each of its terms,  specifically  including without limitation the
amount of the  payment  described  in this  Agreement,  and the fact that he has
received payment,  strictly confidential.  -------------- may disclose the terms
of this  Agreement  only to his attorney or  accountant,  or as required by law.
- ---------------  understands  that Company may be required to publicly  disclose
the terms of this Agreement.

                  5.  NON-DISPARAGEMENT.   --------------  shall  not  make  any
disparaging or derogatory  remarks of any nature  whatsoever about Company,  its
officers, directors or employees, or its products, either publicly or privately,
unless required by law.

                  6.  NON-ADMISSION  OF LIABILITY.  This Agreement  shall not be
construed as an admission of liability or  wrongdoing  by Company.  Neither this
Agreement  nor  any  of its  terms,  provisions,  or  conditions  constitute  an
admission of liability or  wrongdoing  or may be offered or received in evidence
in any  action or  proceeding  as  evidence  of an  admission  of  liability  or
wrongdoing.

                  7.  EMPLOYMENT  AGREEMENT.   --------------  acknowledges  and
reaffirms his  obligations  under Sections 4 and 6 of the  Employment  Agreement
executed by him in conjunction with his employment at Company. The terms of such
Employment  Agreement  are  hereby  incorporated  herein and made a part of this
Agreement.  --------------  agrees to  strictly  comply  with such  terms of the
Employment Agreement.

                  8.  RETURN OF  PROPERTY.  --------------  agrees to and hereby
represents  that he has  returned to Company all of  Company's  property and all
materials  containing  confidential  information  of  Company,  that were in his
possession or under his control.

                  9. MISCELLANEOUS.

                           9.1 ENTIRE AGREEMENT.  This document  constitutes the
entire,  final,  and complete  agreement and  understanding  of the parties with
respect to the subject matter hereof and supersedes and replaces all written and
oral  agreements and  understandings  heretofore made or existing by and between
the  parties  or their  representatives  with  respect  thereto,  other than the
Employment   Agreement  executed  between  the  parties.   There  have  been  no
representations or commitments by Company to make any payment or perform any act
other than those expressly stated herein.


                                      - 2 -
<PAGE>



                           9.2  WAIVER.  No  waiver  of any  provision  of  this
Agreement shall be deemed,  or shall constitute a wavier of any other provision,
whether or not similar,  nor shall any waiver constitute a continuing waiver. No
waiver  shall be binding  unless  executed in writing by the parties  making the
waiver.

                           9.3  BINDING  EFFECT.  All  rights,   remedies,   and
liabilities  herein given to or imposed upon the parties  shall extend to, inure
to the benefit of and bind, as the  circumstances  may require,  the parties and
their representative heirs, personal representatives, administrators, successors
and assigns.

                           9.4  AMENDMENT.   No  supplement,   modification   or
amendment of this  Agreement  shall be valid,  unless the same is in writing and
signed by both parties.

                           9.5 RECOVERY OF ATTORNEY FEES BY PREVAILING PARTY. If
it  becomes  necessary  to  enforce  this  Agreement,  or any part  hereof,  the
prevailing  party shall be entitled to recover its reasonable  attorney fees and
costs incurred therein, including all attorney fees and costs on appeal.

                           9.6 GOVERNING  LAW. This  Agreement and the rights of
the parties  hereunder  shall be governed,  construed and enforced in accordance
with the laws of the state of  Oregon,  without  regard to its  conflict  of law
principles.  Any  suit or  action  arising  out of or in  connection  with  this
Agreement,  or any breach hereof, shall be brought and maintained in the Circuit
Court of the State of Oregon for the County of  Multnomah.  The  parties  hereby
irrevocably  submit to the  jurisdiction  of such court for the  purpose of such
suit or action and hereby expressly and irrevocably waive, to the fullest extent
permitted  by law, any claim that any such suit or action has been brought in an
inconvenient forum.

                           9.7   --------------   GIVEN  21  DAYS  TO   CONSIDER
AGREEMENT.  --------------  acknowledges  that Company advised him in writing to
consult with an attorney  before  signing this  Agreement and that he has had at
least 21 days to consider whether to execute this Agreement.

                           9.8  REVOCATION.   --------------   may  revoke  this
Agreement by written  notice  delivered  to the  President  and Chief  Executive
Officer  of the  Company  within  seven  days  following  the date he signed the
Agreement.  If not revoked under the preceding sentence,  this Agreement becomes
effective and enforceable after the seven-day period has expired.


                                      - 3 -
<PAGE>


                           9.9 MISCELLANEOUS.  --------------  acknowledges that
he  has  freely  and  voluntarily  executed  this  Agreement,  with  a  complete
understanding of its terms and present and future effects.


[NAME OF EMPLOYEE]                               EPITOPE, INC.



                                                 By:

Date:                                            Title:

                                                 Date:



                                      - 4 -

                              EMPLOYMENT AGREEMENT


                  This  Employment  Agreement is entered into as of December --,
1997, between J. Richard George, Ph.D. ("Employee") and Epitope, Inc., an Oregon
corporation (the "Company").

                  1. SERVICES.

                           1.1 EMPLOYMENT. The Company agrees to employ Employee
as Vice President of Scientific Affairs - Epitope Medical Products, and Employee
hereby  accepts such  employment in accordance  with the terms and conditions of
this Agreement. Employment shall continue until terminated pursuant to the terms
of this Agreement.

                           1.2 DUTIES. Employee shall have the position named in
Section 1.1 with such powers and duties appropriate to that office (a) as may be
provided by the bylaws of the Company,  (b) as otherwise  set forth in Exhibit A
attached  to this  Agreement,  and (c) as  determined  from  time to time by the
President and Chief Executive  Officer or the board of directors of the Company.
Employee's  position and duties may be changed from time to time during the term
of this  Agreement,  and  Employee's  place of work may be relocated at the sole
discretion  of the  President  and  Chief  Executive  Officer  or the  board  of
directors.

                           1.3 OUTSIDE  ACTIVITIES.  Employee  shall  obtain the
consent of the President and Chief  Executive  Officer or the board of directors
before he engages,  either directly or indirectly,  in any other professional or
business  activities that may require an appreciable  portion of Employee's time
or effort to the detriment of the Company's business.

                           1.4  DIRECTION  OF  SERVICES.  Employee  shall at all
times  discharge his duties in  consultation  with and under the supervision and
direction of the President and Chief Executive Officer of the Company.

                  2. COMPENSATION AND EXPENSES.

                           2.1 SALARY.  As compensation  for services under this
Agreement, the Company shall pay to Employee a regular salary established by the
President and Chief Executive Officer or the board of directors. Such salary may
be  adjusted  from time to time in the  discretion  of the  President  and Chief
Executive  Officer  or the  board  of  directors.  Payment  shall  be  made on a
bi-weekly  basis,  less all amounts required by law or authorized by Employee to
be withheld or deducted, at such times as shall be determined by the Company.

                           2.2  ADDITIONAL  EMPLOYEE  BENEFITS.  To  the  extent
otherwise eligible, Employee shall also be entitled to receive or participate in
any additional benefits, including without limitation insurance programs, profit
sharing or pension plans, and medical  reimbursement  plans, which may from time
to time be made available by the Company to


                                      - 1 -
<PAGE>


corporate  officers.  The Company may change or discontinue such benefits at any
time in its sole discretion.

                           2.3 EXPENSES.  The Company shall  reimburse  Employee
for all  reasonable and necessary  expenses  incurred in carrying out his duties
under this Agreement. Employee shall present to the Company from time to time an
itemized  account  of such  expenses  in such  form  as may be  required  by the
Company.

                           2.4 FEES. All compensation earned by Employee,  other
than pursuant to this Agreement,  as a result of services performed on behalf of
the Company or as a result of or arising out of any work done by Employee in any
way related to the scientific or business activities of the Company shall belong
to the Company.  Employee shall pay or deliver such  compensation to the Company
promptly upon receipt. For the purposes of this provision,  "compensation" shall
include,  but is not  limited to, all  professional  and  nonprofessional  fees,
lecture fees, expert testimony fees, publishing fees, royalties, and any related
income,  earnings,  or other  things  of  value;  and  "scientific  or  business
activities of the Company" shall include,  but not be limited to, any project or
projects  in which the  Company  is  involved  and any  subject  matter  that is
directly or indirectly researched,  tested, developed,  promoted, or marketed by
the Company.

                  3. STOCK  OPTIONS.  The Company shall grant Employee an option
to purchase  30,000  shares of common stock of the Company at an exercise  price
equal to the fair market value of the stock on the date of grant.

                  4. CONFIDENTIAL INFORMATION.

                           4.1  DEFINED.   "Confidential   Information"  is  all
nonpublic  information relating to the Company or its business that is disclosed
to Employee,  that Employee produces,  or that Employee otherwise obtains during
employment.  "Confidential  Information" also includes information received from
third parties that the Company has agreed to treat as confidential.  Examples of
Confidential Information are:

                           4.1.1 Marketing plans.

                           4.1.2 Customer lists.

                           4.1.3 Product design and manufacturing information.

                           4.1.4 Financial information.

                           4.2 ACCESS TO INFORMATION. Employee acknowledges that
in the course of his employment he will have access to Confidential Information,
that  such  information  is a  valuable  asset  of the  Company,  and  that  its
disclosure or unauthorized use will cause the Company substantial harm.


                                      - 2 -
<PAGE>


                           4.3  OWNERSHIP.   Employee   acknowledges   that  all
Confidential  Information  shall  continue to be the  exclusive  property of the
Company (or the third party that  disclosed it to the  Company),  whether or not
prepared  in  whole or in part by  Employee  and  whether  or not  disclosed  to
Employee or entrusted to his custody in  connection  with his  employment by the
Company.

                           4.4  NONDISCLOSURE  AND NONUSE.  Unless authorized or
instructed  in writing  by the  Company,  or  required  by  legally  constituted
authority,  Employee will not, except as required in the course of the Company's
business,  during  or  after  his  employment,  disclose  to  others  or use any
Confidential  Information,  unless and until,  and then only to the extent that,
such items become available to the public through no fault of Employee.

                           4.5 RETURN OF CONFIDENTIAL INFORMATION.  Upon request
by the  Company  during  or after  his  employment,  and  without  request  upon
termination  of  employment  pursuant to this  Agreement,  Employee will deliver
immediately  to  the  Company  all  written  or  tangible  materials  containing
Confidential Information without retaining any excerpts or copies.

                           4.6  DURATION.  The  obligations  set  forth  in this
Section 4 will continue beyond the term of employment of Employee by the Company
and for so long as Employee possesses Confidential Information.

                  5. MATERIALS  PREPARED AND INVENTIONS MADE DURING  EMPLOYMENT.
The  Company  shall be the  exclusive  owner  of all  materials,  concepts,  and
inventions Employee prepares,  develops, or makes (whether alone or jointly with
others) within the scope of his employment, and of all related rights (including
copyrights,   trademarks,   and  patents)  and  proceeds.   Without  limitation,
materials, concepts, and inventions that (a) relate to the Company's business or
actual or demonstrably  anticipated research or development,  or (b) result from
any work performed by Employee for the Company,  shall be considered  within the
scope of  Employee's  employment.  Employee  shall  promptly  disclose  all such
materials,  concepts,  and  inventions to the Company.  Employee  shall take all
action reasonably  requested by the Company to vest ownership of such materials,
consents,  and  inventions  in the  Company  and to permit the Company to obtain
copyright, trademark, patent, or similar protection in its name.

                  6. TERMINATION.

                           6.1  TERMINATION  UPON DEATH.  This  Agreement  shall
terminate immediately upon Employee's death.

                           6.2  TERMINATION BY EMPLOYEE.  Employee may terminate
his employment under this Agreement by 90 days' written notice to the Company.

                           6.3 TERMINATION BY THE COMPANY FOR CAUSE. The Company
may terminate Employee's  employment under this Agreement for cause at any time,
with or without advance notice.  "Cause" includes,  but is not limited to: (a) a
material breach of this Agreement by Employee; (b) Employee's refusal,  failure,
or inability to comply with any policies or


                                      - 3 -
<PAGE>


standards of the Company or to perform any job duties of  Employee;  (c) any act
of fraud,  dishonesty,  or misconduct by Employee; (d) the commission of any act
in direct  competition  with or materially  detrimental to the best interests of
the Company; or (e) Employee's failure to otherwise comply with the standards of
behavior  that an employer has the right to expect of an  employee.  The Company
reserves the right to determine  the facts giving rise to cause for  termination
and whether those facts constitute cause for termination.

                           6.4  TERMINATION BY THE COMPANY  WITHOUT  CAUSE.  The
Company may terminate  Employee's  employment under this Agreement without cause
by written notice to Employee.

                           6.5 COMPENSATION UPON TERMINATION.

                                    6.5.1 TERMINATION UNDER SECTION 6.1, 6.2, OR
6.3. In the event of a termination of Employee's  employment  under Section 6.1,
6.2, or 6.3,  Employee's regular  compensation  pursuant to Section 2.1 shall be
prorated and payable until the date of termination.

                                    6.5.2  TERMINATION UNDER SECTION 6.4. In the
event of a termination of Employee's  employment by the Company without cause as
provided in Section 6.4,  Employee shall continue to be paid the salary provided
in  Section  2.1 for 12 months  from the date of notice of such  termination  of
employment,  in the manner and at the times at which  regular  compensation  was
paid to Employee during the term of his employment  under this  Agreement.  As a
condition to receipt of the  compensation  described in the preceding  sentence,
Employee shall sign, deliver,  and abide by a Separation  Agreement and Release,
substantially in the form attached as Exhibit B to this Agreement. The Company's
obligation to pay the amounts stated in this section shall terminate if Employee
either  individually  or  as a  director,  officer,  partner,  employee,  agent,
representative, or consultant with any business, directly or indirectly anywhere
in the United States within one year after termination of employment (a) engages
or  prepares to engage in any  business  that  competes  with the  Company;  (b)
induces or  attempts  to induce any person who is an  employee of the Company to
leave the employ of the Company; or (c) solicits, diverts, or accepts orders for
products or services  that are  substantially  competitive  with the products or
services sold by the Company from any customer of the Company.

                  7. REMEDIES.  The respective  rights and duties of the Company
and Employee  under this Agreement are in addition to, and not in lieu of, those
rights  and  duties  afforded  to and  imposed  upon  them by law or at  equity.
Employee  acknowledges  that  breach of Section 4 of this  Agreement  will cause
irreparable  harm  to the  Company  and  agrees  to  the  entry  of a  temporary
restraining   order  and   permanent   injunction  by  any  court  of  competent
jurisdiction to prevent breach or further breach of this Agreement.  Such remedy
shall be in addition to any other  remedy  available to the Company at law or in
equity.

                  8.   SEVERABILITY  OF  PROVISIONS.   The  provisions  of  this
Agreement  are  severable,  and if any  provision  hereof  is  held  invalid  or
unenforceable, it shall be enforced to


                                      - 4 -
<PAGE>


the maximum extent  permissible,  and the remaining  provisions of the Agreement
shall continue in full force and effect.

                  9.  ATTORNEY  FEES.  In the event a suit or action is filed to
enforce Section 4 of this Agreement, the prevailing party shall be reimbursed by
the other party for all costs and expenses  incurred in connection with the suit
or action,  including without limitation reasonable attorney fees at trial or on
appeal.

                  10.  NONWAIVER.  Failure of the Company at any time to require
performance of any provision of this Agreement  shall not limit the right of the
Company to enforce the  provision.  No  provision  of this  Agreement  or breach
thereof may be waived by either party except by a writing  signed by that party.
A waiver of any  breach of a  provision  of this  Agreement  shall be  construed
narrowly and shall not be deemed to be a waiver of any succeeding breach of that
provision or a waiver of that provision itself or of any other provision.

                  11. ARBITRATION.

                           11.1  CLAIMS  COVERED.  All claims or  controversies,
except for those excluded by Section 11.2 ("claims"), whether or not arising out
of Employee's employment (or its termination), that the Company may have against
Employee or that  Employee may have against the Company or against its officers,
directors, employees or agents, in their capacity as such or otherwise, shall be
resolved as  provided in this  Section  11.  Claims  covered by this  Section 11
include,  but are not limited to,  claims for wages or other  compensation  due;
claims for breach of any contract or covenant (express or implied); tort claims;
claims for  discrimination  (including,  but not limited to, race,  sex,  sexual
orientation,  religion,  national origin,  age, marital status,  or disability);
claims for benefits  (except where an employee benefit or pension plan specifies
that its claims procedure shall culminate in an arbitration  procedure different
from this  one),  and claims  for  violation  of any  federal,  state,  or other
governmental  law,  statute,  regulation,  or  ordinance,  except as provided in
Section 11.2.

                           11.2  NON-COVERED  CLAIMS.   Claims  arising  out  of
Section  4  of  this  Agreement  and  workers'   compensation   or  unemployment
compensation  benefits  are not covered by this Section 11.  Non-covered  claims
include but are not limited to claims by the Company for injunctive and/or other
equitable  relief for  unfair  competition  and/or  the use and/or  unauthorized
disclosure of trade secrets or  confidential  information,  as to which Employee
understands  and agrees that the Company may seek and obtain relief from a court
of competent jurisdiction.

                           11.3  REQUIRED  NOTICE OF ALL CLAIMS  AND  STATUTE OF
LIMITATIONS.  Company  and  Employee  agree that the  aggrieved  party must give
written  notice of any claim to the other party  within one year of the date the
aggrieved  party  first has  knowledge  of the event  giving  rise to the claim;
otherwise  the claim shall be void and deemed  waived even if there is a federal
or state statute of  limitations  which would have given more time to pursue the
claim.  The written  notice shall identify and describe the nature of all claims
asserted and the facts upon which such claims are based.


                                      - 5 -
<PAGE>


                           11.4 HEARING OR MEDIATION.  Prior to any  arbitration
proceeding  taking place  pursuant to this section,  Company or Employee may, at
its respective option, elect to submit the claim to non-binding mediation before
a mutually agreeable mediation tribunal or mediator, in which event both parties
shall execute a suitable  confidentiality  agreement and abide by the procedures
specified by the mediation tribunal or mediator.

                           11.5 ARBITRATION PROCEDURES. Any arbitration shall be
conducted in  accordance  with the  then-current  Model  Employment  Arbitration
Procedures  of  the  American  Arbitration  Association  ("AAA"),   modified  to
substitute for AAA actions,  the United States Arbitration and Mediation Service
("USA&MS"), before an arbitrator who is licensed to practice law in the state of
Oregon (the "Arbitrator"). The arbitration shall take place in or near Portland,
Oregon.

                           11.5.1 SELECTION OF ARBITRATOR. The USA&MS shall give
each party a list of 11  arbitrators  drawn  from its panel of  labor-management
dispute  arbitrators.  Each  party  may  strike  all  names on the list it deems
unacceptable.  If only one common name remains on the lists of all parties, that
individual  shall be designated as the Arbitrator.  If more than one common name
remains on the lists of all parties,  the parties shall strike names alternately
until only one  remains.  The party who did not  initiate the claim shall strike
first.  If no common name remains on the lists of all parties,  the USA&MS shall
furnish an additional list or lists until an Arbitrator is selected.

                           11.5.2 APPLICABLE LAW. The Arbitrator shall apply the
substantive  law (and the law of  remedies,  if  applicable)  specified  in this
Agreement or federal law, or both, as applicable to the claim(s)  asserted.  The
Oregon  Rules of Evidence  shall  apply.  The  Arbitrator,  and not any federal,
state, or local court or agency,  shall have exclusive  authority to resolve any
dispute  relating  to  the  interpretation,   applicability,  enforceability  or
formation of this Agreement,  including but not limited to any claim that all or
any part of this Agreement is void or voidable.  The arbitration  shall be final
and binding upon the parties, except as provided in this Agreement.

                           11.5.3   AUTHORITY.   The   Arbitrator   shall   have
jurisdiction to hear and rule on pre-hearing  disputes and is authorized to hold
pre-hearing  conferences  by  telephone  or in  person as the  Arbitrator  deems
necessary.  The  Arbitrator  shall have the  authority  to entertain a motion to
dismiss  and/or a motion for  summary  judgment by any party and shall apply the
standards governing such motions under the Federal Rules of Civil Procedure. The
Arbitrator  shall render an award and opinion in the form typically  rendered in
labor arbitrations.

                                    11.5.4  REPRESENTATION.  Any  party  may  be
represented by an attorney or other representative selected by the party.

                                    11.5.5 DISCOVERY.  Each party shall have the
right to take the deposition of one individual and any expert witness designated
by another  party.  Each party  also shall have the right to make  requests  for
production of documents to any party. The


                                      - 6 -
<PAGE>


subpoena right specified below shall be applicable to discovery pursuant to this
paragraph.  Additional  discovery may be had only where the Arbitrator  selected
pursuant to this  Agreement so orders,  upon a showing of  substantial  need. At
least 30 days  before  the  arbitration,  the  parties  must  exchange  lists of
witnesses, including any experts, and copies of all exhibits intended to be used
at the  arbitration.  Each party shall have the right to subpoena  witnesses and
documents for the arbitration.

                                    11.5.6   REPORTER.   Either  party,  at  its
expense,  may  arrange  for and pay the cost of a court  reporter  to  provide a
stenographic record of proceedings.

                                    11.5.7  POST-HEARING  BRIEFS.  Either party,
upon  request  at  the  close  of  hearing,  shall  be  given  leave  to  file a
post-hearing  brief.  The  time  for  filing  such a brief  shall  be set by the
Arbitrator.

                           11.6 ENFORCEMENT. Either party may bring an action in
any court of competent  jurisdiction to compel  arbitration under this Agreement
and to  enforce an  arbitration  award.  Except as  otherwise  provided  in this
Agreement,  both the Company and Employee  agree that neither shall  initiate or
prosecute any lawsuit (other than for a non-covered claim) in any way related to
any claim covered by this  Agreement.  A party opposing  enforcement of an award
may not do so in an enforcement proceeding,  but must bring a separate action in
any court of competent  jurisdiction to set aside the award,  where the standard
of review will be the same as that  applied by an  appellate  court  reviewing a
decision of a trial court sitting without a jury.

                           11.7 ARBITRATION FEES AND COSTS. Company and Employee
shall  equally  share  the fees and costs of the  Arbitrator.  Each  party  will
deposit  funds  or  post  other  appropriate  security  for  its  share  of  the
Arbitrator's fee, in an amount and manner determined by the Arbitrator,  10 days
before  the first day of  hearing.  Each  party  shall pay for its own costs and
attorneys' fees, if any,  provided that the Arbitrator,  in its sole discretion,
may award reasonable fees to the prevailing party in a proceeding.

                  12. GENERAL TERMS AND CONDITIONS.  This Agreement  constitutes
the entire  understanding  of the parties relating to the employment of Employee
by the Company,  and  supersedes  and  replaces all written and oral  agreements
heretofore made or existing by and between the parties  relating  thereto.  This
Agreement shall be construed in accordance with the laws of the state of Oregon,
without  regard to any conflicts of laws rules  thereof.  This  Agreement  shall
inure to the benefit of any  successors or assigns of the Company.  All captions
used herein are intended solely for convenience of reference and shall in no way
limit any of the provisions of this Agreement.


                                      - 7 -
<PAGE>


                  The parties have executed this Employment  Agreement as of the
date stated above.


                                              EPITOPE, INC.



                                              By:
J. RICHARD GEORGE, PH.D.
                                              Title:


                                      - 8 -
<PAGE>


                        EXHIBIT A TO EMPLOYMENT AGREEMENT

                SPECIFIC DUTIES OF EMPLOYEE AS VICE PRESIDENT OF
                  SCIENTIFIC AFFAIRS - EPITOPE MEDICAL PRODUCTS

[Specify any relevant duties.]







<PAGE>



                        EXHIBIT B TO EMPLOYMENT AGREEMENT

                        SEPARATION AGREEMENT AND RELEASE

         A. This  Separation  Agreement  and Release  ("Agreement")  is made and
entered  into as of this  ----- day of  --------------,  -----,  by and  between
Company,  Inc., an Oregon corporation  ("Company"),  and  ----------------------
("--------------")   in  order  to   provide   the  terms  and   conditions   of
- --------------'s  termination of employment, to fully and completely resolve any
and all issues that  --------------  may have in connection  with his employment
with Company or the termination of that  employment,  and to promote an amicable
long-term relationship between Company and --------------.

         B. In  consideration  of the mutual  promises and conditions  contained
herein, the parties agree as follows:

                  1. SEPARATION. -------------- has been [is currently] employed
at  Company  as  --------------.   --------------  shall  have  no  further  job
responsibilities  at Company after  --------------,  and his employment shall be
terminated effective as of such date.

                  2.  PAYMENT  TO  --------------.  Pursuant  to the  Employment
Agreement entered into between the parties, Company agrees to provide additional
compensation  to  --------------  in  the  amount  of  ---------------  provided
- -------------- executes and does not revoke this Agreement.

                  3. RELEASE OF CLAIMS. In return for the benefits  conferred by
this Agreement (and described in the Employment Agreement), which --------------
acknowledges  Company has no legal obligation to provide if --------------  does
not enter into this  Agreement,  --------------,  on behalf of  himself  and his
heirs,  executors,  administrators,  successors and assigns, hereby releases and
forever  discharges  Company  and  its  past,  present  and  future  affiliates,
subsidiaries,  predecessors,  successors  and  assigns,  and each of their past,
present and future  shareholders,  officers,  directors,  employees,  agents and
insurers,  from  any  and all  claims,  actions,  causes  of  action,  disputes,
liabilities  or damages,  of any kind,  which may now exist or hereafter  may be
discovered,  specifically  including,  but not  limited  to, any and all claims,
disputes,  actions,  causes of action,  liabilities or damages,  arising from or
relating to --------------'s employment with Company, or the termination of such
employment,  except for any claim for  payment or  performance  pursuant  to the
terms of this  Agreement.  This  release  includes,  but is not  limited to, any
claims that  --------------  might have for reemployment or reinstatement or for
additional  compensation  or  benefits  and applies to claims that he might have
under  either  federal,  state or local law dealing with  employment,  contract,
tort,  wage and hour, or civil rights  matters,  including,  but not limited to,
Title VII of the Civil Rights Act of 1964, the Age  Discrimination in Employment
Act, the  Americans  with  Disabilities  Act, the Family and Medical  Leave Act,
similar state laws, and any regulations  under such laws. This release shall not
affect any accrued rights  --------------  may have under any medical insurance,
workers' compensation or retirement plan because of his prior employment with


                                                     - 1 -
<PAGE>


Company.  -------------- ACKNOWLEDGES AND AGREES THAT THROUGH THIS RELEASE HE IS
GIVING UP ALL RIGHTS AND  CLAIMS OF EVERY KIND AND NATURE  WHATSOEVER,  KNOWN OR
UNKNOWN,  CONTINGENT  OR  LIQUIDATED,  THAT HE MAY HAVE AGAINST  Company AND THE
OTHER PERSONS NAMED ABOVE, EXCEPT FOR THE RIGHTS SPECIFICALLY EXCLUDED ABOVE.

                  4.   CONFIDENTIALITY.   --------------  agrees  to  keep  this
Agreement and each of its terms,  specifically  including without limitation the
amount of the  payment  described  in this  Agreement,  and the fact that he has
received payment,  strictly confidential.  -------------- may disclose the terms
of this  Agreement  only to his attorney or  accountant,  or as required by law.
- ---------------  understands  that Company may be required to publicly  disclose
the terms of this Agreement.

                  5.  NON-DISPARAGEMENT.   --------------  shall  not  make  any
disparaging or derogatory  remarks of any nature  whatsoever about Company,  its
officers, directors or employees, or its products, either publicly or privately,
unless required by law.

                  6.  NON-ADMISSION  OF LIABILITY.  This Agreement  shall not be
construed as an admission of liability or  wrongdoing  by Company.  Neither this
Agreement  nor  any  of its  terms,  provisions,  or  conditions  constitute  an
admission of liability or  wrongdoing  or may be offered or received in evidence
in any  action or  proceeding  as  evidence  of an  admission  of  liability  or
wrongdoing.

                  7.  EMPLOYMENT  AGREEMENT.   --------------  acknowledges  and
reaffirms his obligations under Section 4 of the Employment  Agreement  executed
by him in  conjunction  with  his  employment  at  Company.  The  terms  of such
Employment  Agreement  are  hereby  incorporated  herein and made a part of this
Agreement.  --------------  agrees to  strictly  comply  with such  terms of the
Employment Agreement.

                  8.  RETURN OF  PROPERTY.  --------------  agrees to and hereby
represents  that he has  returned to Company all of  Company's  property and all
materials  containing  confidential  information  of  Company,  that were in his
possession or under his control.

                  9. MISCELLANEOUS.

                           9.1 ENTIRE AGREEMENT.  This document  constitutes the
entire,  final,  and complete  agreement and  understanding  of the parties with
respect to the subject matter hereof and supersedes and replaces all written and
oral  agreements and  understandings  heretofore made or existing by and between
the  parties  or their  representatives  with  respect  thereto,  other than the
Employment   Agreement  executed  between  the  parties.   There  have  been  no
representations or commitments by Company to make any payment or perform any act
other than those expressly stated herein.


                                                     - 2 -
<PAGE>


                           9.2  WAIVER.  No  waiver  of any  provision  of  this
Agreement shall be deemed,  or shall constitute a wavier of any other provision,
whether or not similar,  nor shall any waiver constitute a continuing waiver. No
waiver  shall be binding  unless  executed in writing by the parties  making the
waiver.

                           9.3  BINDING  EFFECT.  All  rights,   remedies,   and
liabilities  herein given to or imposed upon the parties  shall extend to, inure
to the benefit of and bind, as the  circumstances  may require,  the parties and
their representative heirs, personal representatives, administrators, successors
and assigns.

                           9.4  AMENDMENT.   No  supplement,   modification   or
amendment of this  Agreement  shall be valid,  unless the same is in writing and
signed by both parties.

                           9.5 RECOVERY OF ATTORNEY FEES BY PREVAILING PARTY. If
it  becomes  necessary  to  enforce  this  Agreement,  or any part  hereof,  the
prevailing  party shall be entitled to recover its reasonable  attorney fees and
costs incurred therein, including all attorney fees and costs on appeal.

                           9.6 GOVERNING  LAW. This  Agreement and the rights of
the parties  hereunder  shall be governed,  construed and enforced in accordance
with the laws of the state of  Oregon,  without  regard to its  conflict  of law
principles.  Any  suit or  action  arising  out of or in  connection  with  this
Agreement,  or any breach hereof, shall be brought and maintained in the Circuit
Court of the State of Oregon for the County of  Multnomah.  The  parties  hereby
irrevocably  submit to the  jurisdiction  of such court for the  purpose of such
suit or action and hereby expressly and irrevocably waive, to the fullest extent
permitted  by law, any claim that any such suit or action has been brought in an
inconvenient forum.

                           9.7   --------------   GIVEN  21  DAYS  TO   CONSIDER
AGREEMENT.  --------------  acknowledges  that Company advised him in writing to
consult with an attorney  before  signing this  Agreement and that he has had at
least 21 days to consider whether to execute this Agreement.

                           9.8  REVOCATION.   --------------   may  revoke  this
Agreement by written  notice  delivered  to the  President  and Chief  Executive
Officer  of the  Company  within  seven  days  following  the date he signed the
Agreement.  If not revoked under the preceding sentence,  this Agreement becomes
effective and enforceable after the seven-day period has expired.


                                      - 3 -
<PAGE>



                           9.9 MISCELLANEOUS.  --------------  acknowledges that
he  has  freely  and  voluntarily  executed  this  Agreement,  with  a  complete
understanding of its terms and present and future effects.


[NAME OF EMPLOYEE]                               EPITOPE, INC.



                                                 By:

Date:                                            Title:

                                                 Date:



                                      - 4 -

                              AMENDED AND RESTATED
                           EMPLOYEE BENEFITS AGREEMENT


                  THIS AMENDED AND RESTATED EMPLOYEE BENEFITS
AGREEMENT (this  "Agreement") is entered into by and between  Epitope,  Inc., an
Oregon  corporation  ("Epitope"),  and  Agritope,  Inc., a Delaware  corporation
("Agritope"), as of December 19, 1997.


                                    RECITALS

                  A. The board of directors of Epitope has determined that it is
in the best interests of Epitope and its shareholders to separate the businesses
of Epitope and Agritope.

                  B. In  furtherance  of the plan to  separate  the  businesses,
Epitope and Agritope have entered into that certain  Separation  Agreement dated
December 1, 1997 (the  "Separation  Agreement"),  pursuant to which Epitope will
make a dividend distribution to its shareholders (the "Distribution") of all the
issued and  outstanding  shares of  Agritope  common  stock,  par value $.01 per
share,  including certain preferred stock purchase rights attached thereto, held
by Epitope, on the terms and conditions contained therein.

                  C. In connection with the  Distribution,  Epitope and Agritope
desire to provide for the  allocation  between them of assets,  liabilities  and
responsibilities with respect to certain employee compensation and benefit plans
and programs following the Distribution.

                  NOW,  THEREFORE,  in  consideration  of the  foregoing and the
mutual covenants and agreements contained herein,  Epitope and Agritope agree as
follows:

                                    ARTICLE 1
                                   DEFINITIONS

                  Capitalized  terms  shall  have the  meanings  given  below or
elsewhere in this Agreement, or as set forth in the Separation Agreement.

                  401(k) Retirement Plan: A defined contribution plan maintained
pursuant  to  Section  401(k)  or  401(a)  of the Code for  Employees  and their
beneficiaries. The following are specific 401(k) Retirement Plans:

                  (i)      Agritope  401(k)  Plan:  The  Agritope,  Inc.  401(k)
                           Profit  Sharing Plan to be adopted by Agritope  prior
                           to the  Distribution  Date pursuant to Section (a) of
                           this Agreement.

                  (ii)     Epitope 401(k) Plan: The Epitope,  Inc. 401(k) Profit
                           Sharing Plan, in effect as of the date hereof.


                                      - 1 -
<PAGE>


                  Additional   Insurance   Plans:   Insurance   plans  providing
insurance  benefits  other  than  Medical/Dental  Plan  benefits  to  Employees,
including Life Insurance and Accidental Death and Dismemberment Insurance.

                  Agritope Board:  The board of directors of Agritope.

                  Agritope Option Plan: The Agritope, Inc. 1997 Stock Award Plan
to be adopted pursuant to Section of this Agreement.

                  Agritope Stock Distribution Value: See definition in Section .

                  Agritope  Stock  Plans:  The  Agritope  Option  Plan  and  the
Agritope Purchase Plan. Each Agritope Stock Plan will contain  substantially the
same material provisions as the corresponding Epitope Plan.

                  Distribution Date: The effective date of the Distribution,  as
determined by the Epitope board of directors.

                  Distribution  Ratio:  The  number  (which  may be or include a
fraction)  of shares of  Agritope  Stock to be  issued  in the  Distribution  to
Epitope  shareholders  for each  share of  Epitope  Stock as  determined  by the
Epitope Board.

                  Employee:  An individual who, on the Distribution  Date, is an
employee of either Epitope or Agritope or any of its subsidiaries. There will be
two categories of Employees after the Distribution:

                           Agritope Employee:  Any individual who is an employee
                  of Agritope or any of its subsidiaries  immediately  after the
                  Distribution.

                           Epitope  Employee:  Any individual who is an employee
                  of Epitope immediately after the Distribution.

                  Epitope Option Plans: The Epitope, Inc. Incentive Stock Option
Plan and the Epitope, Inc. 1991 Stock Award Plan.

                  ERISA: The Employee Retirement Income Security Act of 1974, as
amended, or any successor legislation.

                  Existing  Agritope Option Plan: The Agritope,  Inc. 1992 Stock
Award Plan.

                  Existing Epitope Option:  Each unexercised  option to purchase
Epitope  Stock  outstanding  as of the close of  business  on the day before the
Distribution  Date,  issued  pursuant to an Epitope  Option Plan or the Existing
Agritope Option Plan.


                                      - 2 -
<PAGE>


                  Medical/Dental  Plan:  A plan  providing  health  benefits  to
Employees and their dependents, including:

                   (i) Agritope  Medical/Dental  Plans: The Medical/Dental Plans
         to be established by Agritope in accordance with Section hereof and

                   (ii) Epitope Medical/Dental Plans: The Epitope Medical/Dental
         Plans in effect as of the date hereof and  continued  by Epitope  after
         the Distribution Date.

                  Plan:  Any plan,  policy,  arrangement,  contract or agreement
providing  compensation  or  benefits  for any  group  of  Employees  or for any
individual  Employee or the  dependents or  beneficiaries  of any such Employee,
including  without  limitation any employee welfare and employee pension benefit
plans (as defined in ERISA) and any employee  option  plans.  The term "Plan" as
used in this Agreement does not include any contract, agreement or understanding
entered  into by  Epitope  or  Agritope  relating  to  settlement  of  actual or
potential employee-related litigation claims.

                  Purchase Plan: A stock-based  Plan meeting the requirements of
Section 423 of the Code. The following are specific Purchase Plans:

                           (i) Agritope  Purchase Plan: The Agritope,  Inc. 1997
                  Employee  Stock  Purchase Plan to be adopted by Agritope prior
                  to the Distribution Date pursuant to Section .

                           (ii) Epitope  Purchase Plan:  The Epitope,  Inc. 1993
                  Employee Stock Purchase Plan, as amended,  in effect as of the
                  date hereof.

                  Qualified  Beneficiary:  An individual (or dependent  thereof)
who either (1) experiences a "qualifying event" (as that term is defined in Code
Section   4980B(f)(3)  and  ERISA  Section  603)  while  a  participant  in  any
Medical/Dental  Plan, or (2) becomes a "qualified  beneficiary" (as that term is
defined  in Code  Section  4980B(g)(1)  and  ERISA  Section  607(3))  under  any
Medical/Dental Plan.

                  Service Time: The period taken into account under any Plan for
purposes  of  determining  length of  service or plan  participation  to satisfy
eligibility, vesting, benefit accrual and similar requirements under such Plan.

                  Welfare  Plan:  Any  Plan  that  provides   medical,   health,
disability,  accident,  life  insurance,  death,  dental  or any  other  welfare
benefit, including, without limitation, any post-employment benefit.


                                      - 3 -
<PAGE>


                                    ARTICLE 2
                             EMPLOYMENT AND CREDITS

         2.1  Allocation  of  Responsibilities  on  Distribution  Date.  On  the
Distribution  Date,  except as otherwise  agreed  between the parties,  Agritope
shall retain or assume, as the case may be, sole  responsibility as employer for
Agritope  Employees,  and shall cause any Agritope Employee that is then a party
to any employment,  change in control or other employment-related agreement with
Epitope to  terminate  such  agreement  effective  as of the  Distribution  Date
(except  confidentiality,   indemnification,  and  similar  agreements  relating
primarily  to past  services to Epitope).  Except as otherwise  provided in this
Agreement,  the fact that Agritope assumes or retains responsibility as employer
of Agritope  Employees as of the Distribution  Date shall not, of itself,  cause
such employee to be deemed  terminated  under any Plan  maintained by Epitope or
Agritope.

         2.2 Service Time.  For purposes of  determining  Service Time under any
Welfare Plan,  Agritope shall credit each Agritope Employee with such Employee's
Service Time and original hire date as may be reflected in Epitope's  employment
records  as of the  Distribution  Date.  Such  Service  Time and hire date shall
continue to be maintained for as long as the Employee's employment with Agritope
does not terminate.  Agritope shall be free to make such determinations relating
to  Service  Time  under  any  Agritope  Stock  Plans as  Agritope,  in its sole
discretion, deems appropriate. Subject to the provisions of ERISA, Agritope may,
in its sole discretion, make such decisions as it deems appropriate with respect
to  determining  Service Time for any Agritope  Employee whose  employment  with
Agritope is terminated  following the Distribution  Date but who is subsequently
reemployed by Agritope.

                                    ARTICLE 3
                                  STOCK OPTIONS

         3.1 Amendment of Epitope Option Plans.  Prior to the Distribution Date,
Epitope  shall take all action  necessary and  appropriate  to amend the Epitope
Option Plans and, to the extent necessary and permissible without the consent of
option holders, outstanding options issued under the plans to be consistent with
the terms of this Section .

                  (a)  Effect  of  Employment  by  Agritope.   For  purposes  of
         determining  the period during which  Existing  Epitope  Options remain
         exercisable,  employment  by  Agritope  or any of  its  majority  owned
         subsidiaries following the Distribution Date shall be deemed employment
         by Epitope,  notwithstanding the fact that Agritope will no longer be a
         subsidiary of Epitope  after the  Distribution  Date.  For continued or
         future  vesting and all other  purposes  relating  to Existing  Epitope
         Options,   employment  by  Agritope  or  any  of  its  majority   owned
         subsidiaries after the Distribution Date shall not be deemed employment
         by Epitope.  Accordingly,  any affected  holder of an Existing  Epitope
         Options  granted  under  Epitope  Option  Plans  will be  treated  as a
         terminated  employee and options will continue to vest according to the
         schedule provided in the applicable award agreement.


                                      - 4 -
<PAGE>



                  (b) Adjustment to Exercise Price of Existing  Epitope Options.
         The per share  exercise  price of each Existing  Epitope  Option issued
         under the  Epitope  Option  Plans  shall be  reduced  one day after the
         Distribution Date by subtracting the Agritope Stock  Distribution Value
         (as defined  below) from the stated  exercise  price.  "Agritope  Stock
         Distribution  Value"  is equal to (a) $7,  being the price per share at
         which  foreign  investors  have  agreed  to  purchase  Agritope  Stock,
         multiplied  by (b) the  number  of shares of  Agritope  Stock  that are
         issued in the  Distribution  or that  investors  have  agreed as of the
         Distribution  Date to  purchase,  plus the  214,285  shares of Agritope
         Preferred to be purchased by Vilmorin & Cie,  divided by (c) the number
         of shares of Epitope Stock outstanding on the Record Date.

         3.2  Amendment  of  Existing   Agritope  Option  Plan.   Prior  to  the
Distribution  Date,  Agritope shall take all action necessary and appropriate to
amend the Existing Agritope Option Plan and/or  outstanding Award Agreements (as
defined in the Existing  Agritope  Option Plan) entered into in connection  with
the Plan to be consistent with the terms of this Section .

                  (a) Issuance of Epitope  Stock Upon  Exercise.  Epitope  Stock
         shall be issued  upon  exercise  of Existing  Epitope  Options  granted
         pursuant to the Existing Agritope Option Plan, notwithstanding the fact
         that the  options are  denominated  in shares of  Agritope  Stock.  The
         existing  agreement between Epitope and Agritope providing for issuance
         of  Epitope  Stock upon  exercise  of such  options  will be amended to
         remain in effect following the Distribution.

                  (b)  Effect of the  Distribution.  If the  holder of  Existing
         Epitope Options  granted under the Existing  Agritope Option Plan is an
         Agritope  Employee  after  the  Distribution,  such  holder  shall  for
         continued  or  future  vesting  purposes  be deemed  terminated  on the
         Distribution  Date but, for purposes of determining  the period options
         remain  exercisable,  such holder shall not be deemed  terminated until
         employment by Agritope is  terminated.  Accordingly,  Existing  Epitope
         Options granted under the Existing  Agritope Option Plan shall continue
         to vest  following  the  Distribution  Date  according  to the  vesting
         schedule applicable to terminated employees set forth in the applicable
         Award  Agreement.  If such option holder is an Epitope  Employee,  such
         options shall  continue to vest and be  exercisable as set forth in the
         Existing Agritope Option Plan or outstanding Award Agreements.

                  (c)  Adjustment  to  Exercise  Price of Options  Issued  Under
         Existing  Agritope  Plan. The per share exercise price of each Existing
         Epitope  Option issued under the Existing  Agritope  Option Plan (which
         price is stated in terms of  Agritope  Stock)  shall be reduced one day
         after the  Distribution  Date by subtracting  from the stated  exercise
         price  the  product  of (a)  the  Agritope  Stock  Distribution  Value,
         multiplied  by (b) the number  (which will be a fraction)  of shares of
         Epitope Stock to be issued in lieu of each share of Agritope  Stock for
         which the option is exercised.


                                      - 5 -
<PAGE>


                  (d) No Further  Option  Grants.  Agritope  shall not grant any
         additional options under the Existing Agritope Option Plan.

         3.3 Effect of the Distribution on Change in Control Provisions. Nothing
in this Agreement or in any amendment to the Epitope Option Plans,  the Existing
Agritope  Option Plan or to any award  agreement  issued under any Plan shall be
interpreted to modify the change in control  provisions in any Existing  Epitope
Options. Existing Epitope Options shall continue to become immediately and fully
vested and  exercisable as to all shares covered by such option upon a Change in
Control  Date (as  defined in the terms and  conditions  applicable  to Existing
Epitope Options).

         3.4 Adoption of Agritope Option Plan. Prior to the  Distribution  Date,
Agritope shall take, or cause to be taken,  all action necessary and appropriate
(i) to prepare and ratify the adoption of the Agritope  Option Plan, and (ii) to
present  the  Agritope  Option  Plan to  Epitope,  as the  sole  shareholder  of
Agritope, for approval.  Agritope and Epitope shall cooperate in the adoption of
the Agritope Option Plan and the reservation for issuance under the plan of such
shares of Agritope Stock as are deemed necessary and appropriate by the Agritope
Board.

         3.5 Communication  Regarding Termination Of Employment.  Agritope shall
notify Epitope of the termination of employment of any Agritope Employee holding
an Existing Epitope Option within ten days of such termination. Such notice with
respect to  termination  shall  specify  the date of  termination,  whether  the
termination  was for cause or came as a result  of  retirement,  and such  other
information as Epitope shall reasonably request.

                                    ARTICLE 4
                              STOCK PURCHASE PLANS

         4.1 Epitope  Purchase Plan. The Epitope  Purchase Plan will continue in
full  force and effect in  accordance  with its  terms.  Participants  under the
Epitope Purchase Plan will be eligible to participate in the  Distribution  only
to the extent that, by operation of the Epitope Purchase Plan or otherwise, they
are  shareholders  of  record  on  the  Record  Date;  provided,  however,  that
participants  who are entitled to receive  shares of Epitope  Common Stock under
the  Epitope  Purchase  Plan  as of the  Record  Date  but  have  not  yet  been
mechanically  recorded  as  shareholders  of record on the  Record  Date will be
treated as shareholders of record for purposes of the  Distribution.  Employment
by Agritope or any of its majority-owned subsidiaries following the Distribution
Date shall not be deemed  employment  by Epitope  for  purposes  of the  Epitope
Purchase  Plan and any  Agritope  Employee  shall  be  treated  as a  terminated
employee  under the  Epitope  Purchase  Plan.  For  purposes  of the  continuing
operation of the Epitope Purchase Plan, Epitope will adjust the Maximum Purchase
Price (as defined in the Epitope Purchase Plan) to account for the effect of the
Distribution  by  subtracting  the Agritope  Stock  Distribution  Value from the
Maximum Purchase Price.


                                      - 6 -
<PAGE>


         4.2 Adoption of Agritope Purchase Plan. Prior to the Distribution Date,
Agritope shall take, or cause to be taken,  all action necessary and appropriate
(i) to ratify the adoption of the Agritope  Purchase  Plan,  and (ii) to present
the Agritope Purchase Plan to Epitope, as the sole shareholder of Agritope,  for
approval.

                                    ARTICLE 5
                               OTHER BENEFIT PLANS

         5.1      401(k) Retirement Plans.

                  (a)  Establishment of Agritope 401(k) Plan.  Effective January
         1,  1998,  Agritope  shall  establish  and  thereafter  administer  the
         Agritope  401(k) Plan,  in such form as may be approved by the Agritope
         Board,  which is intended to qualify under Sections 401(a),  501(a) and
         401(k) of the Code and to be in  compliance  with the  requirements  of
         ERISA.  The  Agritope  401(k)  Plan will  provide  credit for  services
         rendered  to  Epitope  or  any  of  its   subsidiaries   prior  to  the
         Distribution Date in determining Service Time.

                  (b)  Continuation  of  Benefits.   Agritope   Employees  shall
         continue to be eligible to participate in the Epitope 401(k) Plan until
         such  time as the  Agritope  401(k)  Plan is  established  and  becomes
         effective.  Effective as of the effective  date of the Agritope  401(k)
         Plan,  which is expected to be January 1, 1998,  Agritope  will provide
         benefits under the Agritope  401(k) Plan to all Agritope  Employees who
         were  participants  in, or otherwise  entitled to benefits  under,  the
         Epitope 401(k) Plan. All Agritope  Employees who wish to participate in
         the  Agritope  401(k) Plan will be  required to enroll in the  Agritope
         401(k) Plan in accordance with its terms.

                  (c) Vesting and Distribution of Accounts.  Agritope  Employees
         shall  become  fully  vested  (if not  already  fully  vested) in their
         Matching Accounts,  as defined under the Epitope 401(k) Plan, as of the
         Distribution Date. Agritope Employees shall be entitled to distribution
         from  the  Epitope  401(k)  Plan  of all of  their  accounts  within  a
         reasonable time after the  Distribution  Date. The Agritope 401(k) Plan
         shall accept a rollover  contribution  from any  Agritope  Employee who
         elects that their  distribution  from the Epitope 401(k) Plan be rolled
         over to the Agritope 401(k) Plan.

                  (d)  Epitope to Provide  Information.  Epitope  shall  provide
         Agritope,  as soon as practicable  after the Distribution  Date, with a
         list of Agritope Employees who, to the best knowledge of Epitope,  were
         participants  in or  otherwise  entitled to benefits  under the Epitope
         401(k) Plan on the Distribution  Date,  together with a listing of each
         participant's  Service Time under the Epitope 401(k) Plan and a listing
         of each such Agritope  Employee's account balance  thereunder.  Epitope
         shall  provide  Agritope  with  such  additional   information  in  the
         possession of Epitope or Epitope's agent as may be reasonably requested
         by Agritope  related to the  effective  administration  of the Agritope
         401(k) Plan.


                                      - 7 -
<PAGE>


                  (e)  Cooperation.  Agritope and Epitope  shall,  in connection
         with the plan-to-plan transfer described in , use their best efforts to
         cooperate in the  plan-to-plan  transfer of funds and in making any and
         all  appropriate  filings  required by the  Commission  or the Internal
         Revenue Service,  or required under the Code,  ERISA, or any applicable
         securities laws and the regulations thereunder.

                  (f)  Effect  of  the   Distribution.   The   Distribution  and
         subsequent  transfer  of  account  balances  shall not be  treated as a
         termination  or partial  termination  of the Epitope  401(k) Plan or of
         Agritope Employees under the Epitope 401(k) Plan.

         5.2      Medical/Dental Plan Liability and Coverage.

                  (a) Continuation of Coverages After the Distribution.  Epitope
         shall continue to provide coverage to Agritope  Employees under Epitope
         Medical/Dental Plans after the Distribution Date until such time as new
         medical/dental plans are established by Agritope.  If during the period
         from the Distribution  Date until the establishment of Agritope Medical
         and Dental Plans,  Epitope,  in its reasonable  discretion,  determines
         that   continued   coverage  of  Agritope   Employees   under   Epitope
         Medical/Dental  Plans will have an adverse effect on the business plans
         or strategies of Epitope,  Epitope may, upon 90 days written  notice to
         Agritope,   terminate  such  coverage.  After  the  Distribution  Date,
         Agritope  shall  be  responsible   for  all  costs  under  the  Epitope
         Medical/Dental  Plans attributable to Agritope  Employees,  as shall be
         determined by Epitope in its reasonable discretion.

                  (b)  Agritope   Medical/Dental   Plans.   Unless  the  parties
         otherwise agree, Agritope shall establish Agritope Medical/Dental Plans
         to provide  coverages to Agritope  Employees  substantially  similar to
         those available under the corresponding Epitope Medical/Dental Plans on
         or before  January 1, 1999. In  connection  with the  establishment  of
         Agritope  Medical/Dental  Plans,  Agritope Employees and their eligible
         dependents  and  beneficiaries  shall  have  no  preexisting  condition
         limitation  imposed  other than that which is or was imposed  under the
         plan or plans in which  they were  enrolled  before  the date  Agritope
         Medical/Dental  Plans are established and become effective (the "Cutoff
         Date"),  and  will  be  credited  with  any  expenses  incurred  toward
         deductibles,  out-of-pocket expenses, maximum benefit payments, and any
         benefit usage toward plan limits that would have been applicable  under
         the plan or plans in which they were enrolled before the Cutoff Date.

                  (c)  Responsibility  for  Coverages  after  the  Cutoff  Date.
         Immediately  after the Cutoff Date,  Agritope shall provide coverage to
         Agritope  Employees  under  Agritope   Medical/Dental   Plans.  Epitope
         Medical/Dental  Plans shall continue to be responsible  for claims that
         arise  prior to the  Cutoff  Date  subject  to the  cost  reimbursement
         provisions set forth in Section .


                                      - 8 -
<PAGE>


                  (d) COBRA. Epitope shall be responsible for complying with the
         requirement  of Code  Section  4980B  and  Part 6 of  Title I of  ERISA
         ("COBRA Requirements") with respect to any Employee in its group health
         plan and their "qualified  beneficiaries"  whose "qualifying event" (as
         such  terms are  defined in Code  Section  4980B)  occurs  prior to the
         Distribution  Date.  After the  Distribution  Date,  Agritope  shall be
         responsible  for  compliance  with COBRA  Requirements  with respect to
         Agritope  Employees  whose  "qualifying  event"  occurs on or after the
         Distribution Date.

                  (e) No Qualifying  Event.  The  Distribution  described in the
         Separation Agreement shall not, by itself,  create a "qualifying event"
         (as described in Code Section 4980B(f)(3) and ERISA Section 603).

                  (f) Refunds.  In the event that subsequent to the Cutoff Date,
         refunds  are  received  from  carriers   providing  medical  or  dental
         insurance,   such  refunds  will  belong  to  Epitope,  to  the  extent
         attributable to Epitope Employees.  Agritope shall receive such refunds
         to  the  extent  attributable  to  Agritope  Employees,   as  shall  be
         determined by Epitope in its reasonable discretion.

         5.3      Life Insurance/Accidental Death and Dismemberment Coverages.

                  (a) Continuation of Coverages After the Distribution.  Epitope
         shall  continue  to  provide  coverage  to  Agritope   Employees  under
         Epitope's  Additional Insurance Plans after the Distribution Date until
         such time as Additional Insurance Plans are established by Agritope. If
         during the period from the Distribution Date until the establishment by
         Agritope of Additional  Insurance  Plans,  Epitope,  in its  reasonable
         discretion,  determines that continued  coverage of Agritope  Employees
         under Epitope's  Additional Insurance Plans will have an adverse effect
         on the business  plans or strategies  of Epitope,  Epitope may, upon 90
         days' written notice to Agritope,  terminate  such coverage.  After the
         Distribution  Date,  Agritope shall be responsible  for all costs under
         Epitope's   Additional   Insurance   Plans   attributable  to  Agritope
         Employees,  as  shall  be  determined  by  Epitope  in  its  reasonable
         discretion.

                  (b) Agritope's  Additional Insurance Plans. Unless the parties
         otherwise agree, Agritope shall establish Additional Insurance Plans to
         provide coverages to Agritope Employees  substantially similar to those
         available under Epitope's  corresponding  Additional Insurance Plans on
         or before January 1, 1999.

                  (c) Responsibility for Coverages. Immediately after Agritope's
         Additional  Insurance Plans become effective,  Agritope shall be solely
         responsible   for  providing  all  coverages   relating  to  Additional
         Insurance Plans to Agritope Employees.


                                      - 9 -
<PAGE>



         5.4 Vacation And Sick Pay  Liabilities.  Effective on the  Distribution
Date, Epitope shall retain, as to Epitope  Employees,  and Agritope shall assume
or  retain,  as the case  may be,  as to  Agritope  Employees,  all  liabilities
(whether  vested or unvested,  and whether  funded or unfunded) for vacation and
sick  leave  accrued  as of the  Distribution  Date.  Agritope  shall be  solely
responsible for the payment of such vacation or sick leave to Agritope Employees
after the  Distribution  Date. Each of Epitope and Agritope shall provide to its
own Employees on the Distribution  Date the same vested and unvested balances of
vacation  and sick leave as  credited to such  Employee  on the Epitope  payroll
systems  as of the  Distribution  Date.  Nothing  in  this  Agreement  shall  be
construed  to limit  the right of  either  Epitope  or  Agritope  to change  its
vacation or sick leave policies as it deems appropriate.

         5.5 Flexible Spending Accounts.  Effective as of the Distribution Date,
Agritope shall establish  Flexible Spending Account Plans that are substantially
equivalent to those currently provided by Epitope. Spending account balances for
Agritope  Employees  will  not  be  transferred  by  Epitope  to the  new  plans
established  by  Agritope.  Agritope  Employees  will  have  90 days  after  the
Distribution  Date to make  claims  for  payment  from their  existing  spending
account balances.

                                    ARTICLE 6
                                 RELATED MATTERS

         6.1 Notice of Costs.  Epitope and Agritope acknowledge that Epitope and
Agritope may have incurred or may incur costs and expenses,  including,  but not
limited to, contributions to Plans and the payment of insurance premiums arising
from or related to any of the Plans  that are,  as set forth in this  Agreement,
the responsibility of the other party hereto. Accordingly,  Epitope and Agritope
shall (i) give notice to the other party of the costs and  expenses  incurred or
the costs and expenses to be incurred  and (ii) demand that the other party,  if
it has the obligation to pay, pay or reimburse the cost and expense.

         6.2      Payroll Reporting And Withholding.

                  (a) Agritope and Epitope hereby adopt the "standard procedure"
         for  preparing and filing IRS Forms W-2 (Wage and Tax  Statements)  and
         W-3 (Transmittal of Income and Tax Statements), as described in Section
         4 of Revenue Procedure 96-60 ("Rev. Proc. 96-60"). Under this procedure
         Epitope  must  perform  all  reporting  duties  for the wages and other
         compensation it has paid to Employees prior to the  Distribution  Date,
         including the furnishing and filing of Forms W-2 and W-3. Agritope will
         be  responsible  for all  reporting  duties  for the  wages  and  other
         compensation it pays to Agritope Employees.

                  (b)  Epitope  will  keep on file  all  Forms  W-4  (Employee's
         Withholding  Allowance  Certificate)  and  W-5  (Earned  Income  Credit
         Advance Payment Certificate)  provided by Agritope Employees.  Agritope
         Employees must provide Agritope with new Forms W-4 and W-5 for the year
         in which the Distribution occurs.


                                     - 10 -
<PAGE>


                  (c) With respect to Agritope Employees with garnishments,  tax
         levies,  child support orders,  qualified medical child support orders,
         and wage assignments in effect with Epitope on the  Distribution  Date,
         Agritope  shall be  responsible  for honoring  such  payroll  deduction
         authorizations  or court or governmental  orders applicable to Agritope
         Plans, and will continue to make payroll deductions and payments to any
         authorized payee, as specified by the court or governmental  order that
         was filed  with  Epitope.  Epitope  shall  provide  Agritope  with full
         information about any such matters before the Distribution Date.

                  (d) Unless  otherwise  prohibited  by law or  provided by this
         Agreement  or another  agreement  entered into in  connection  with the
         Distribution, or by a Plan document, with respect to Agritope Employees
         with  authorizations  for payroll  deductions in effect with Epitope on
         the Distribution  Date,  Agritope as the successor  employer will honor
         such  payroll  deduction   authorizations  relating  to  each  Agritope
         Employee,  and shall not require that such Agritope  Employee  submit a
         new  authorization to the extent that the type of deduction by Agritope
         does not differ from that made by Epitope.  Any such payroll  deduction
         in favor of Epitope  shall  continue to be  withheld  by  Agritope  for
         Epitope's benefit.

         6.3 Access to Records and  Confidentiality.  Epitope  shall  retain all
employment records,  personnel files, and other information  relating to Epitope
Employees and payroll  records  relating to Agritope  Employees.  Agritope shall
take possession of all personnel and employment records, except payroll records,
relating to Agritope Employees after the Distribution Date. Agritope and Epitope
will make  available  to the other  party  such  records,  documents,  and other
information  relating to employment  matters  involving  Agritope  Employees and
other  matters  covered in this  Agreement as may be reasonably  requested.  The
parties  shall  cooperate  in  providing  any  information   necessary  for  the
resolution  of any dispute  that may arise  between  Epitope or Agritope and any
third party arising out of subject matter  covered by this  Agreement  after the
Distribution  Date.  Epitope and Agritope will each,  upon  adequate  notice and
reasonable  request,  make its employees and  facilities  available to the other
party  and  shall  permit  the other  party to copy at its own  expense  records
relating to Agritope Employees as necessary and appropriate.  Except as required
by law or with the prior written  consent of Epitope and any affected  Employee,
all records,  documents,  and other information  provided to Agritope by Epitope
related to Agritope  Employees and other matters covered in this Agreement shall
be kept  confidential  by  Agritope  and its  representatives  and  shall not be
disclosed to any other person or entity.

                                    ARTICLE 7
                               EMPLOYMENT MATTERS

         7.1  Separate  Employers.  After the  Distribution  Date,  Epitope  and
Agritope will be separate and independent employers.


                                     - 11 -
<PAGE>



         7.2 Employment  Policies And Practices.  Epitope and Agritope may adopt
such employment  policies,  compensation  practices,  retirement plans,  welfare
benefit  plans,  and other  employee  benefit  plans or  policies of any kind or
description,  as each may determine,  in its sole discretion,  are necessary and
appropriate,  in  addition to those  required  under this  Agreement.  Except as
otherwise  expressly  provided  herein,  no provision of this Agreement shall be
construed  as a  limitation  on the right of  Epitope  or  Agritope  to amend or
terminate any policies, practices, or Plan.

         7.3 Funding Of Plans.  Any claims by or on behalf of  Employees  or any
federal,  state or local  government  agency  for  alleged  underfunding  of, or
failure to make payments to, health and welfare funds based on acts or omissions
occurring on or before the  Distribution  Date or arising from or in  connection
with the Distribution,  will be the sole  responsibility of each party as to its
own employees (i.e., Epitope with respect to Epitope Employees and Agritope with
respect to Agritope Employees).

         7.4 Employment Tax Rates. Agritope shall comply with ORS Chapter 657 in
determining  whether to assume the state  unemployment tax experience of Epitope
for purposes of establishing its own unemployment tax experience rates.

                                    ARTICLE 8
                                  MISCELLANEOUS

         8.1  Indemnification.  Each party to this  Agreement  shall  indemnify,
defend, and hold harmless the other party against losses incurred as a result of
claims  relating to matters  covered in this Agreement to the extent provided in
the Separation Agreement. In addition, subject to the indemnification procedures
set forth in the Separation Agreement:

                  (a)  Indemnification  by  Epitope.  Epitope  shall  indemnify,
         defend,  and  hold  harmless  Agritope  and its  subsidiaries  from and
         against any  liabilities  incurred  as a result of claims made  against
         Agritope by Epitope Employees  relating to or arising out of employment
         of Epitope Employees by Epitope after the Distribution  Date,  employee
         benefits provided to Epitope Employees after the Distribution  Date, or
         termination  in connection  with the  Distribution  of any Employee who
         becomes or remains an  Epitope  Employee  on or after the  Distribution
         Date; and

                  (b)  Indemnification  by Agritope.  Agritope shall  indemnify,
         defend,  and hold harmless Epitope and any future subsidiary of Epitope
         from and  against any  liabilities  incurred as a result of claims made
         against  Epitope by  Agritope  Employees  relating to or arising out of
         employment  of Agritope  Employees by Agritope  after the  Distribution
         Date,  employee  benefits  provided  to  Agritope  Employees  after the
         Distribution  Date, or termination in connection with the  Distribution
         of any Employee who becomes or remains an Agritope Employee on or after
         the Distribution Date.


                                     - 12 -
<PAGE>


         8.2 No Third-Party Beneficiaries.  No provision of this Agreement shall
be construed to create a right in any Employee,  or dependent or  beneficiary of
such Employee,  including  without  limitation any right under a Plan which such
person  would  not  otherwise  have  under the  terms of the Plan  itself.  This
Agreement is for the benefit of the parties hereto and is not intended to confer
upon any other person except the parties hereto any rights or remedies.

         8.3  Attorney-Client  Privilege.  Consistent  with  the  provisions  of
Section 6.6 of the Separation  Agreement,  provisions  requiring either party to
this  Agreement  to  cooperate  shall  not  be  deemed  to be a  waiver  of  the
attorney/client  privilege for either party nor shall they require  either party
to waive its attorney/client privilege.

         8.4 Dispute Resolution. Any disputes between the parties arising out of
or related to this  Agreement  shall be  resolved or decided as set forth in the
Separation Agreement.

         8.5 Relationship of the Parties. Neither party is an agent of the other
party and neither party has any authority to bind the other party,  transact any
business in the other  party's  name or on its behalf,  or make any  promises or
representations  on behalf  of the other  party  unless  otherwise  agreed to in
writing.  Each party will perform all of its respective  obligations  under this
Agreement as an independent contractor.

         8.6 Entire Agreement.  This Agreement  constitutes the entire agreement
between the parties with respect to the subject matter hereof and supersedes all
prior written or oral agreements between the parties with respect to the subject
matter hereof,  including the Employee  Benefits  Agreement  between the parties
dated as of December 1, 1997.

         8.7 Governing Law. This  Agreement  shall be governed by, and construed
and enforced in accordance with, the laws of the state of Oregon.

         8.8  Jurisdiction and Venue.  Subject to the arbitration  provisions of
the Separation  Agreement,  each party consents to the personal  jurisdiction of
the state and federal  courts  located in the state of Oregon and hereby  waives
any argument that venue in any such forum is not convenient or proper.

         8.9 Notices.  All notices,  requests,  demands and other communications
under this  Agreement  shall be in writing and shall be deemed to have been duly
given  (i) on the date of  service  if  served  personally  on the party to whom
notice  is  given;  (ii)  on the  day of  transmission  if  sent  via  facsimile
transmission  to  the  facsimile   number  given  below,   provided   telephonic
confirmation of receipt is obtained  promptly after  completion of transmission;
(iii) on the business day after delivery to an overnight  courier service or the
express mail service  maintained by the United States Postal  Service,  provided
receipt of delivery has been confirmed;  or (iv) on the fifth day after mailing,
provided receipt of delivery is confirmed, if mailed to the party to whom notice
is to be given,  by  registered or certified  mail,  postage  prepaid,  properly
addressed and return-receipt requested, to the party as follows:


                                     - 13 -
<PAGE>



                  If to Epitope:            Epitope, Inc.
                                            8505 S.W. Creekside Place
                                            Beaverton, Oregon  97008
                                            Facsimile No. (503) 641-8665

                  If to Agritope:           Agritope, Inc.
                                            8505 S.W. Creekside Place
                                            Beaverton, Oregon  97008
                                            Facsimile No. (503) 520-6196

Any party may change its address and facsimile  number by giving the other party
written  notice of its new address and facsimile  number in the manner set forth
above.

         8.10 Modification of Agreement. No modification, amendment or waiver of
any provision of this Agreement  shall be effective  unless the same shall be in
writing  and signed by each of the  parties  hereto and then such  modification,
amendment or waiver shall be effective only in the specific instance and for the
purpose for which given.

         8.11  Successors and Assigns.  This Agreement shall be binding upon and
inure to the benefit of the parties hereto and their  respective  successors and
permitted assigns,  but neither this Agreement nor any of the rights,  interests
or  obligations  hereunder  shall be assigned by either party  without the prior
written  consent of the other party,  and such consent shall not be unreasonably
withheld.

         8.12  Titles  and  Headings.  Titles  and  headings  included  are  for
convenience  and are not  intended  to  constitute  a part of or to  affect  the
meaning or interpretation of this Agreement.

         8.13 Severability.  In case any one or more of the provisions contained
in  this   Agreement   should  be  invalid,   illegal  or   unenforceable,   the
enforceability  of the  remaining  provisions  hereof  shall  not in any  way be
affected or impaired thereby.

         8.14 No Waiver.  Neither  the  failure nor any delay on the part of any
party  hereto to exercise  any right  under this  Agreement  shall  operate as a
waiver thereof,  nor shall any single or partial  exercise of any right preclude
any other or  further  exercise  of the same or any other  right,  nor shall any
waiver of any right with respect to any  occurrence  be construed as a waiver of
such right with respect to any other occurrence.

         8.15 Survival. All covenants and agreements of the parties contained in
this Agreement will survive for five years following the Distribution Date.


                                     - 14 -
<PAGE>


         8.16 Counterparts.  This Agreement may be executed in counterparts, all
of which shall be  considered  one and the same  agreement,  and shall  become a
binding agreement when a counterpart has been signed by each party and delivered
to the other party.

         IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be
executed and delivered as of the date first written above.

EPITOPE, INC.


By:
Its:


AGRITOPE, INC.


By:
Its:



                                     - 15 -

                  TRANSITION SERVICES AND FACILITIES AGREEMENT


   
          This TRANSITION SERVICES AND FACILITIES  AGREEMENT (this "Agreement"),
dated as of December 1, 1997, is between  EPITOPE,  INC., an Oregon  corporation
("Epitope"), and AGRITOPE, INC., a Delaware corporation ("Agritope").
    

          Agritope  desires to engage  Epitope to provide  certain  services and
facilities  for  Agritope,  and Epitope  desires to provide  such  services  and
facilities for Agritope, on the terms and conditions set forth herein.

   
          Capitalized  terms not otherwise defined shall have the meanings given
in Section 6.
    

          Epitope and Agritope agree as follows:

          1. Services.  Agritope hereby engages  Epitope to provide  Services to
Agritope  at such  times as  Agritope  may  reasonably  request.  In  performing
Services,  Epitope  shall use the same degree of care that it uses in connection
with its own  business.  Nothing  in this  Agreement  shall  require  Epitope to
provide  Services at a time or in a manner that would  interfere with the normal
conduct of Epitope's business.

          2. Facilities. Epitope hereby agrees to provide Facilities to Agritope
until such time as Agritope  relocates  its office and research and  development
operation to other leased Facilities.

          3.  Subcontractors.  With  Agritope's  consent,  which  shall  not  be
unreasonably  withheld,  Epitope may engage  third  parties to provide  Services
under this Agreement to Agritope.  Epitope may do so without  Agritope's consent
for Services usually provided to Epitope by third parties.

          4. Payments for Services and Facilities.

               4.1 Services  Payments.  Agritope shall reimburse Epitope for all
Services Costs.  After the end of each month or such other period as the parties
may agree,  Epitope  shall  submit an invoice to  Agritope  for  Services  Costs
incurred  during the  period.  Any delay in  delivering  the  invoice  shall not
relieve Agritope of its reimbursement obligations. Agritope shall pay the amount
of each invoice  within 10 days after  receiving  it.  Amounts not paid when due
shall, at Epitope's  option,  accrue late charges at the rate of 1.5 percent per
month.



<PAGE>


               4.2  Calculation  of  Services  Costs.  "Services  Costs" are all
direct and indirect  costs  incurred by Epitope in providing  Services,  whether
paid or accrued.  Services Costs shall be determined  using  Epitope's  internal
cost  accounting  system.  Epitope shall allocate costs of personnel who provide
services to both Epitope and  Agritope,  and indirect  costs such as general and
administrative  costs, on a reasonable basis consistent with Epitope's  internal
cost accounting  system.  Upon reasonable notice to Epitope,  Agritope personnel
shall have the right to review Epitope  records to verify the  determination  of
Services Costs.

   
               4.3 Facilities Payment.  Agritope shall pay Epitope a monthly fee
of $15,945 for use of the Facilities on the first day of each month.


          5.   Term and Termination.

               5.1 Initial Term and Renewals. The initial term of this Agreement
shall expire on December 31, 1997, but this  Agreement  shall continue in effect
for successive  one-month terms  thereafter  unless either party gives the other
written notice of termination at least 15 days before expiration of any term.

               5.2  Termination.  Either  party  may  terminate  this  Agreement
effective immediately upon written notice to the other party if such other party
fails to perform any of its material  obligations  under this Agreement and such
failure  continues  for a period of 60 days, or 10 days in the case of a failure
to make payment, after written notice thereof from the non-breaching party.

          6.  Definitions.  Capitalized  terms  not  otherwise  defined  in this
Agreement shall have the respective meanings set forth below:

               6.1  "Affiliate"  of a Person  means a Person that  directly,  or
indirectly through one or more intermediaries, controls, is controlled by, or is
under common control with such Person.

               6.2 "Agritope  Personnel"  means  Agritope,  its  successors  and
assigns, and the directors, officers, employees, and agents thereof.


                                       2
<PAGE>


               6.3 "Facilities"  means the portion of Epitope's office space and
research  and  development  facilities  in  Beaverton,   Oregon,  consisting  of
approximately  6,300 square feet of office,  manufacturing  and laboratory space
currently used by Agritope and the related fixtures and furniture.

               6.4 "Force Majeure" means any act of nature, accident, explosion,
fire, storm,  earthquake,  flood, drought, peril of the sea, riot, embargo, war,
foreign,  federal,  state or municipal  order of general  application,  seizure,
requisition,  allocation,  failure  or  delay  of  transportation,  shortage  of
supplies,  equipment,  fuel or labor, or other  circumstance or event beyond the
reasonable control of affected party.

               6.5.  "Services"  means the  services  listed in  Schedule  A, as
amended from time to time,  and any other  services  requested by Agritope  that
Epitope agrees to provide.

               6.6. "Services Costs" has the meaning given in Section 4.2.

          7.   General.

               7.1 Amendments.  Any  modification of this Agreement or waiver of
terms must be in writing and signed by the party to be bound.

               7.2 Assignment. Except as provided below or in Section 3, neither
may assign its rights or delegate its obligations  under this Agreement  without
the  written  consent  of the other  party.  Epitope  may  assign its rights and
delegate its obligations to an Affiliate or a successor to Epitope's business if
the  Affiliate or  successor  assumes all of  Epitope's  obligations  under this
Agreement.

               7.3 Attorney Fees. In any litigation  concerning  this Agreement,
the  prevailing  party shall be entitled to recover all  reasonable  expenses of
litigation,  including  reasonable  attorney  fees at trial and on any appeal or
petition for review.

               7.4 Execution in Counterparts.  This Agreement may be executed in
counterparts which together shall constitute one instrument.

               7.5  Entire  Agreement.  This  Agreement  constitutes  the entire
agreement  and  understanding  between the parties  with  respect to its subject
matter and supersedes any prior agreement or understanding.


                                       3
<PAGE>

               7.6 Force Majeure.  Neither party shall be liable for any failure
or delay in performing its obligations,  other than payment obligations,  caused
by Force  Majeure.  The other party may,  however,  terminate  this Agreement as
permitted  in Section 5.2 if such  failure or delay  continues  for more than 60
days.

               7.7  Governing  Law.  This  Agreement  shall be  governed  by and
construed in accordance with Oregon law.

               7.8 Headings. Headings in this Agreement are for convenience only
and shall not affect its meaning.

               7.9 No Agency. Nothing in this Agreement creates any partnership,
employment or agency relationship between the parties.  Neither party shall have
the right to act on behalf of or bind the  other,  and  neither  shall  take any
action that could lead a third party to believe it has the right to do so.

               7.10 Notices.  Notices under this Agreement  shall be in writing,
shall refer specifically to this Agreement,  and shall be personally  delivered,
sent by electronic facsimile transmission promptly confirmed by mail, or sent by
registered or certified mail, return receipt requested, postage prepaid, in each
case to the  respective  address or facsimile  number  specified  below (or such
other address or number as may be specified by notice to the other party):
    

               Epitope, Inc.
               8505 S.W. Creekside Place
               Beaverton, Oregon 97008
               Attention:  President
               Fax:  (503) 641-8665

   
               Agritope, Inc.
               8505 S.W. Creekside Place
               Beaverton, Oregon  97008
               Attention:  President
               Fax:  (503) 520-6196

Any notice or communication  given in conformity with this Section 7.10 shall be
deemed to be effective when received by the  addressee,  if delivered by hand or
electronic facsimile transmission, or three days after mailing, if mailed.

               7.11  Severability.  If any  provision of this  Agreement is held
invalid or  unenforceable  in any  jurisdiction,  then,  to the  fullest  extent
permitted  by law,  (a) the  affected  provision  shall remain in full force and
effect in all other jurisdictions, (b) all other provisions shall remain in full


                                       4
<PAGE>

force and effect,  and (c) the parties  will use their best  efforts to find and
employ other means to achieve the same or substantially  the same result as that
contemplated by the provision held invalid or unenforceable.
    

          The parties have executed  this  Agreement as of the date first stated
above.

                                  EPITOPE, INC.


                                  By /s/ John W. Morgan
                                    President and Chief
                                    Executive Officer

                                  AGRITOPE, INC.


   
                                  By /s/ Adolph J. Ferro
                                    Chairman, President and Chief
                                    Executive Officer
    





                                       5
<PAGE>


                                   SCHEDULE A
                                   ----------


   
     1.Management  information  services  consisting  of  software  support  and
hardware maintenance at the rate of $1,690 per month.

     2. Telephone services based on third-party billings.

     3. Equipment maintenance, other than computer hardware, on call at the rate
of $25 per hour.

     4. Front desk receptionist services at no charge (Agritope will provide its
own telephone receptionist services).
    






                            TAX ALLOCATION AGREEMENT



   
       This agreement (the  "Agreement")  dated as of December 1, 1997, is being
entered into by Epitope,  Inc., an Oregon  corporation,  and  Agritope,  Inc., a
Delaware corporation, in connection with a Separation Agreement (the "Separation
Agreement") dated as of December 1, 1997 by and between such parties.
    

                                    RECITALS

       A. Agritope is currently a wholly owned  subsidiary  of Epitope,  and, as
such,  Epitope  and  Agritope  have  joined in filing  consolidated  federal Tax
Returns (as defined below) and certain consolidated,  combined or unitary state,
local, or foreign Tax Returns;

       B.  Pursuant  to the  Separation  Agreement,  Epitope  will,  among other
things, distribute to holders of its common stock all the issued and outstanding
common stock of Agritope,  together with  associated  preferred  stock  purchase
rights (the "Distribution");

       C. Following the  Distribution,  Epitope and Agritope will be operated as
independent  public  companies,  and  Agritope  will no longer be a wholly owned
subsidiary of Epitope; and

       D. Epitope and Agritope  want to provide for the  allocation  between the
Epitope   Group  and  the   Agritope   Group   (both   defined   below)  of  all
responsibilities,  liabilities,  and  benefits  relating to or  affecting  Taxes
(defined  below)  paid or  payable  by either of them for all  taxable  periods,
whether  beginning before or after the Distribution  Date (defined below) and to
provide for certain other matters.

       ACCORDINGLY,  in  consideration of the foregoing and the mutual covenants
and  agreements  contained  in this  Agreement,  Epitope and  Agritope  agree as
follows:

1.    ADDITIONAL DEFINITIONS; CERTAIN TAX PERIODS.

     1.1  ADDITIONAL TAX  DEFINITIONS.  As used in this  Agreement,  capitalized
terms defined  immediately after their use will have the respective  meanings so
provided,  and the following  additional terms will have the following  meanings
(such meanings to be equally applicable to both the singular and plural forms of
the terms defined):

   
       "Agritope" means Agritope,  Inc., a Delaware  corporation,  the successor
corporation in that certain merger with Agritope,  Inc., an Oregon  corporation,
dated December 1, 1997.
    


                                       1
<PAGE>


              "Agritope  Group" means Agritope and all of its present and future
subsidiaries.

              "Agritope  Taxes"  means,  subject to Section  1.3,  (i) all Taxes
imposed on, assessed against,  collected with respect to, or measured by the net
or gross income,  profits,  receipts,  assets, equity, or other basis related to
the Agritope Group or its respective  assets or operations  that arise in or are
attributable to any and all  Pre-Closing  Periods and  Post-Closing  Periods and
(ii) all Reserved Taxes.

              "Agritope Tax Returns"  means all Tax Returns filed or required to
be filed by or with respect to any member of the Agritope Group or its assets or
operations (including any consolidated, combined, or unitary Tax Returns).

              "Code"  means the Internal  Revenue Code of 1986,  as amended from
time to time.

              "Distribution  Date" means the date on which  Epitope  distributes
the stock of Agritope in accordance with the Separation Agreement.

   
              "Epitope" means only Epitope,  Inc., an Oregon  corporation,  as a
separate legal entity, excluding all other affiliated corporations.
    

              "Epitope  Group"  means  Epitope and all of its present and future
subsidiaries (excluding members of the Agritope Group).

              "Epitope  Taxes" means,  subject to Section 1.3, all Taxes imposed
on, assessed against, collected with respect to, or measured by the net or gross
income, profits, receipts, assets, equity, or other basis related to the Epitope
Group or its respective  assets or operations that arise in or are  attributable
to any and all Pre-Closing Periods, excluding any Reserved Tax and excluding any
Agritope Taxes.

              "Pre-Closing  Periods" means all taxable  periods (i) ending on or
before  the  Distribution  Date and  (ii)  the  portion,  to and  including  the
Distribution  Date,  of  any  taxable  period  that  begins  on  or  before  the
Distribution Date and ends after the Distribution Date.

              "Post-Closing  Periods"  means all taxable  periods (i)  beginning
after the Distribution  Date and (ii) the portion after the Distribution Date of
any taxable period that begins on or before the Distribution Date and ends after
the Distribution Date.

              "Reserved  Tax"  means  a  Tax  liability  separately  accrued  or
deferred  on the  balance  sheet of any member of the  Agritope  Group as of the
Distribution  Date.  Taxes  will be accrued  on such  balance  sheet in a manner
consistent with past practices.

                                       2
<PAGE>

              "Tax"  means any and all  liability  for any taxes  imposed on the
income or assets of a corporation,  including without limitation,  any liability
under the Code and all federal,  state,  local, and foreign income,  alternative
minimum, franchise,  profits, gross receipts, and unitary taxes or similar taxes
or other fees or assessments  imposed with respect to such items irrespective of
the basis on which such  taxes are  measured  and any  interest,  penalties,  or
additions in respect of such tax.

              "Tax Return"  means any return,  report,  information  return,  or
other  documents  (including  any related  supporting  schedules,  statements or
information)   filed  or  required  to  be  filed  with  any  tax  authority  or
governmental  entity  in  connection  with  the  determination,  assessment,  or
collection  of  any  Taxes  of any  party  or the  administration  of any  laws,
regulations, or administrative requirements relating to any such Taxes.

     1.2 TAX  PERIODS  INCLUDING  PRE-CLOSING  PERIOD  AND  POST-CLOSING  PERIOD
ACTIVITY. For purposes of determining Agritope Taxes, for Tax periods that begin
on or before the  Distribution  Date and end after the  Distribution  Date, such
Taxes  will be  determined  on the basis of an  interim  "closing  of the books"
computation as of the end of the Distribution Date, and any net operating losses
(or other tax  attributes)  will be subject to Section 1.3.  With respect to the
Epitope  federal  consolidated  income tax return for the taxable year including
the Distribution Date,  appropriate allocation and cutoff of income or loss will
be made as required in the federal  consolidated  income tax return regulations.
Any subsequent adjustments occurring with respect to such period,  including the
Distribution Date, will be appropriately allocated to the Pre-Closing Period and
the Post-Closing Period based on a simulated Tax Return for each period.

     1.3 PRE-CLOSING PERIOD NET OPERATING LOSSES.

          (a) In accordance with Treasury Regulations Section 1.1502-11(b),  net
operating losses of the Agritope Group will not be used to offset gain or income
recognized by Epitope in connection with the Distribution.

          (b) Subject to the limitations of Section 1.3((a)),  any net operating
losses (or other tax  attributes)  of a member of the Agritope  Group or Epitope
Group that arise in a  Pre-Closing  Period will be available  to offset  taxable
income  of  members  of the  other  group  for  such  Pre-Closing  Period  under
applicable  federal or state law. The  provisions of this Section  1.3((b)) will
apply to any net  operating  losses (or other tax  attributes)  existing  on the
Distribution  Date and such net operating  losses (or tax  attributes)  that may
arise subsequently on audit or examination of any Pre-Closing  Period. No member
of a group  will be liable to a member of the other  group  under  Section 2 for
using net  operating  losses (or other tax  attributes)  generated by members of
such other group.

                                       3
<PAGE>

2. INDEMNIFICATION AND PAYMENT

     2.1 PAYMENT OF AND INDEMNIFICATION FOR TAXES.

          (a) Epitope will pay when due, without setoff,  and be responsible for
all Epitope Taxes assessed against it by any  jurisdiction,  including any Taxes
incurred by the Epitope Group in connection with the Distribution.  Epitope will
indemnify and hold harmless the Agritope Group against any and all such Taxes.

          (b) Agritope will pay when due, without setoff, and be responsible for
all Agritope Taxes assessed against it by any jurisdiction,  including,  without
limitation,   any  liability   imposed   subsequently  for  Agritope  Taxes  for
Pre-Closing Periods. Agritope will indemnify and hold harmless the Epitope Group
against any such Taxes.

          (c) No member of the Epitope  Group will be  obligated to indemnify or
hold  harmless  any member of the  Agritope  Group for any  decrease  to any net
operating  loss  carryovers  or  credit  (or the  carryovers  of any  other  tax
attributes)  available  to any  member  of the  Agritope  Group  resulting  from
adjustments  to any item of  income,  deduction,  credit,  or  exclusion  on Tax
Returns for which Epitope is  responsible  (including  the Epitope  Consolidated
Returns, as defined below).

          (d) No member of the Agritope  Group will be obligated to indemnify or
hold  harmless  any  member of the  Epitope  Group for any  increase  to any net
operating  loss  carryovers  or  credit  (or the  carryovers  of any  other  tax
attributes) available to any member of the Agritope Group.

3.    REFUNDS

     3.1 EPITOPE  REFUNDS.  Agritope will promptly assign and remit (or cause to
be promptly  assigned and remitted) to Epitope an amount equal to any refunds of
or credits  against any Taxes  received  and  realized  by  Agritope  (including
interest,  if any) to the extent  attributable  to Epitope  Taxes,  other than a
refund or credit (or the right to a refund or credit)  that is  reflected on the
balance  sheet  of  Agritope  as of the  Distribution  Date  (a  "Balance  Sheet
Refund").

     3.2 AGRITOPE  REFUNDS.  Epitope will promptly assign and remit (or cause to
be promptly  assigned  and  remitted) to Agritope an amount equal to all Balance
Sheet Refunds.

     3.3 CARRYBACK  FROM AN AGRITOPE  POST-CLOSING  PERIOD RETURN TO ANY EPITOPE
SEPARATE,  CONSOLIDATED  OR COMBINED  FEDERAL OR STATE TAX RETURN.  Unless:  (i)
Epitope,  in its sole and  absolute  discretion,  consents to do so or (ii) such
carryback  is  specifically  required by law,  Agritope  will not carry back any
losses or  credits  accruing


                                       4
<PAGE>

after the Distribution Date in any Post-Closing  Period to any Epitope separate,
consolidated,  or combined  federal or state Tax Return.  Agritope will make any
elections and take all such actions  necessary to avoid and  relinquish any such
carryback  pursuant to Code Section  172(b)(3) and, to the extent feasible,  any
similar provision of any state, local, or foreign law. Even if such carryback is
required by law, the Epitope  Group will make no payment to the Agritope  Group,
and the Agritope  Group will be entitled to no refund to the extent that the use
of such  carryback  prevents the Epitope  Group or its  affiliates  from using a
credit  or loss  that it would  otherwise  use in the year or years to which the
Agritope  credit or loss is carried back. To the extent that the Epitope Group's
utilization  of such loss or  credit  does not have such  effect,  however,  the
Epitope  Group will pay to Agritope an amount equal to the  reduction in its Tax
liability for such year that is attributable to the utilization of such Agritope
Group credit or loss.

4.    TAX RETURNS

     4.1 PREPARATION AND FILING.

          (a)  Epitope  will  file  (upon  execution  of such Tax  Return  by an
authorized  officer of Agritope,  which  authorization  will not be unreasonably
withheld)  all Agritope  Group Tax Returns for  Pre-Closing  Periods  ("Agritope
Group Pre-Closing Returns"),  including,  without limitation, all Agritope Group
Tax Returns  that are (or are a part of) a  consolidated  or combined Tax Return
that includes entities other than members of the Agritope Group, even if the Tax
period with  respect to such other  entities  ends after the  Distribution  Date
("Epitope Consolidated Returns").

          (b) Epitope  will  prepare the  Epitope  Consolidated  Returns (to the
extent they relate to the Agritope  Group or its assets or  operations)  and the
Agritope  Group  Pre-Closing  Returns in a manner that:  (i) is consistent  with
prior practice  (including without limitation as to Tax and accounting  methods,
conventions,  and elections) and (ii) apportions  items equitably from period to
period consistent with Section 1.2. Epitope will cause the Epitope  Consolidated
Returns to include and reflect the activities,  transactions,  and operations of
the Agritope Group for all Pre-Closing Periods.

          (c) Agritope will file all Agritope  Group Tax Returns  required to be
filed for all Post-Closing Periods other than Agritope Group Pre-Closing Returns
and Epitope  Consolidated  Returns (the "Agritope Group Post-Closing  Returns").
However,  with respect to an Agritope Group Post-Closing  Return that is for (i)
Taxes of Agritope and (ii) a Tax year with  respect to the  Agritope  Group that
begins  on or before  the  Distribution  Date (an  "Agritope  Overlap  Return"),
Agritope will (a) have a national  "Big 6" accounting  firm prepare the Agritope
Overlap Return consistent with prior practice, including, without limitation, as
to Tax and  accounting  methods,  conventions,  and  elections  and (b)  provide
Epitope  with an  opportunity  to review and comment on such Tax Return at least
four weeks before its due date, including  extensions.  The parties will use all
reasonable  efforts to resolve any  disagreements  with  respect to any such Tax
Return as soon as  possible.  If



                                       5
<PAGE>

they cannot  resolve the matter  before the due date for such  Agritope  Overlap
Return,  including  extensions,  Agritope may nevertheless file such Tax Return.
Subsequently,  the  parties  will  refer  the  matter to a  mutually  acceptable
accounting  firm (other than the firm that  prepared the returns) of  nationally
recognized  standing  (an  "Independent  Firm")  whose  fees  are to be borne by
Agritope  and Epitope  equally.  The  Independent  Firm will seek to resolve the
matter as soon as practicable.  Upon the Independent  Firm's  determination,  an
amended   Agritope  Overlap  Return  will  be  filed  in  accordance  with  such
determination if it differs materially from the Tax Return filed originally.

          (d) Agritope, upon its request, will be entitled to copies of Agritope
Group Pre-Closing Returns and Epitope  Consolidated Returns following the filing
to the extent they relate to any member of the Agritope Group.

     4.2 TAX  RETURN  PAYMENTS.  Amounts  shown  due on any  Agritope  Group Tax
Returns  will  be  timely  paid by the  party  responsible  for  such  Taxes  as
determined  in accordance  with Section 2 of this  Agreement  (the  "Responsible
Party")  regardless of which party is obligated to prepare or file such Agritope
Group Tax Return under this Section 4. The party  obligated to file a particular
Agritope  Group Tax Return  (the  "Filing  Party")  has the  right,  but not the
obligation  unless it is the  Responsible  Party,  to pay the Tax shown due,  in
which case the Responsible Party will immediately reimburse the Filing Party for
the payment of such Tax.

5.    INFORMATION EXCHANGE AND CONFIDENTIALITY

     5.1  COOPERATION.  Upon  the  reasonable  request  of  any  party  to  this
Agreement,  the other party will promptly provide the requesting party with such
cooperation and assistance,  documents,  and other information as may reasonably
be requested by such party in connection with: (i) the preparation and filing of
any  original  or amended  Tax  Return;  (ii) the  conduct of any audit or other
examination or any judicial or administrative proceeding involving to any extent
Taxes  or Tax  Returns  within  the  scope  of  this  Agreement;  or  (iii)  the
verification by a party of an amount payable to or receivable from another party
under this Agreement (collectively, "Tax Data"). Such cooperation and assistance
will include, without limitation: (i) the provision on demand of books, records,
Tax Returns,  documentation,  or other information  relating to any relevant Tax
Return;  (ii) the  execution of any document that may be necessary or reasonably
helpful in connection  with the filing of any Tax Return or in  connection  with
any audit, proceeding,  suit, or action of the type generally referred to in the
preceding sentence; (iii) the prompt and timely filing of appropriate claims for
refund;  and (iv) the use of reasonable efforts to obtain any documentation from
a  governmental  authority  or a third party that may be necessary or helpful in
connection with the foregoing  (collectively,  "Tax Documentation").  Each party
will make its employees and facilities  available on a mutually convenient basis
to facilitate such cooperation.


                                       6
<PAGE>

     5.2  RETENTION.  The Tax Data and the Tax  Documentation  will be  retained
until the later of (i) 90 days after the expiration of the applicable statute of
limitations  (including any waivers or extensions for any Taxes or net operating
loss  carryovers  available  in any tax year);  (ii)  eight (8) years  after the
Distribution Date; and (iii) any retention period required by law or pursuant to
any record retention  agreement;  provided,  however, if an audit,  examination,
investigation,  or other  proceeding is instituted  before the expiration of the
applicable  statute  of  limitations  (or in the event of any claim  under  this
Agreement),  such Tax Data and Tax Documentation will be retained until there is
a final determination and the time for any appeal has expired.

     5.3 EXPENSES.  Subject only to the provisions of Section 6, each party will
cooperate in the manner described in this Section 5 at its own expense.

     5.4 NOTIFICATION OF CARRYOVERS.  Epitope will undertake  reasonable efforts
to notify  Agritope  of (i) any  carryover  of losses or  credits  that could be
partially  or totally  attributed  to and carried  over by Agritope  pursuant to
Treasury  Regulations  Section  1.1502-79 or any similar law, rule or regulation
and (ii) any subsequent adjustment that could affect any such item.

     5.5 NOTIFICATION TO SHAREHOLDERS. Epitope will undertake reasonable efforts
to provide each Epitope  shareholder who receives Agritope Common Stock pursuant
to the  Separation  Agreement  with the  information  necessary  to permit  such
shareholder  to properly  report the receipt of shares of Agritope  stock in the
Distribution for federal income tax purposes.

     5.6  CONFIDENTIALITY.  Except as required by law or with the prior  written
consent  of the other  party,  all (i) Tax  Returns,  (ii) Tax  Data,  (iii) Tax
Documentation, (iv) similar documents, schedules, work papers and items, and (v)
all  information  contained  in such  items  which are  within the scope of this
Agreement will be kept  confidential  by the parties and their  representatives,
will not be disclosed  to any other person or entity,  and will be used only for
the purposes provided in this Agreement.

6.    CONTESTS AND AUDITS

     6.1 NOTICE AND COOPERATION.

          (a) If any claim, demand,  assessment  (including a notice of proposed
assessment),  or other  assertion,  whether  oral or written,  is made for Taxes
("Tax Claim") against a party entitled to  indemnification  with respect to such
Taxes  pursuant  to  this  Agreement  (an  "Indemnitee"),  or if the  Indemnitee
receives any notice, whether oral or written, from any jurisdiction with respect
to any current or future audit,  examination,  investigation or other proceeding
("Proceeding"),  the Indemnitee  will promptly  notify the party obligated to so
indemnify the  Indemnitee  (the  "Indemnitor")  of such Tax Claim or


                                       7
<PAGE>

notice  of a  Proceeding.  If an  Indemnitor  receives  notice of a Tax Claim or
notice of a  Proceeding,  whether oral or written,  for which the  Indemnitor is
responsible  under this  Agreement,  such  Indemnitor  will promptly  notify the
Indemnitee of such claim,  demand, or assessment if such Tax Claim or Proceeding
could directly or indirectly  affect  (adversely or otherwise)  any  Indemnitee,
determined without regard to this Agreement.

          (b) The party  controlling the defense,  settlement,  or compromise of
any  Proceeding  or any Tax Claim  with  respect  to a Tax Return or any Tax (as
determined  pursuant to Section 6.2) will keep the other party duly  informed of
the progress of such  Proceeding  or Tax Claim to the extent such  Proceeding or
Tax Claim could  directly or indirectly  affect  (adversely  or otherwise)  such
other party, determined without regard to this Agreement.

          (c) If the Indemnitor  controls the defense,  settlement or compromise
of any Proceeding or Tax Claim for which it is responsible,  the Indemnitee will
nevertheless cooperate in such defense,  settlement, or compromise as and to the
extent  reasonably  requested  by  Indemnitor.   Such  cooperation  will  be  at
Indemnitor's expense (on a current basis), including all liabilities, costs, and
expenses  (including  reasonable attorney fees and accounting fees but excluding
in-house legal or tax assistance)  incurred in connection with such  cooperation
and authorized by the Indemnitor.

          (d) If the  Indemnitor  does not control the defense,  settlement,  or
compromise of any Proceeding or Tax Claim for which it is  responsible,  it will
nevertheless  (i) cooperate at its own expense in such defense,  settlement,  or
compromise to the extent reasonably requested by Indemnitee,  and (ii) indemnify
(on a current basis) the Indemnitee against any reasonable  liabilities,  costs,
and expenses  (including  reasonable  attorney and accounting fees but excluding
in-house legal or tax  assistance)  arising out of or incident to the Proceeding
or Tax Claim,  including without  limitation,  those incurred in connection with
the defense, settlement, or compromise of such Proceeding or Tax Claim.

     6.2 CONTROL.

          (a) Except as otherwise  provided in Section  6.2((b)) or Section 6.3,
the  Indemnitor  will have the right to  control  the  defense,  settlement,  or
compromise  of any  Proceeding  or Tax Claim to the extent that it may be liable
under Section 2 of this Agreement.

          (b) Notwithstanding the provisions of Section 6.2((a)) (and subject to
the provisions of Section 6.3):

               (1) an Indemnitee (in lieu of the Indemnitor) will have the right
(but not the  obligation) to control the defense,  compromise,  or settlement of
any  Proceeding  or Tax Claim if the  Indemnitor  fails to do so or requests the
Indemnitee to do so;

                                       8
<PAGE>

               (2) an Indemnitee (in lieu of the Indemnitor) will have the right
(but not the  obligation) to control the defense,  compromise,  or settlement of
any  Proceeding or Tax Claim if the Indemnitor is (a) the subject of a voluntary
bankruptcy,  (b) an adjudicated  bankrupt,  or (c) the subject of an involuntary
petition  in  bankruptcy  that has been filed and which has not been  discharged
within 90 days;

               (3) Epitope will control the defense,  settlement,  or compromise
of any Proceeding or Tax Claim with respect to any Epitope  Consolidated  Return
and any Agritope Group Pre-Closing Return; and

               (4) Agritope will control the defense,  settlement, or compromise
of any Proceeding or Tax Claim with respect to any Agritope  Group  Post-Closing
Return,  including any Agritope  Overlap  Return (but  exclusive of any Agritope
Group  Pre-Closing  Return).  With respect to Agritope Overlap Returns,  Epitope
may, at its own expense, attend meetings or conferences with the Tax authorities
and receive copies of all relevant correspondence.

6.3    APPROVAL.

          (a) The Indemnitee will not settle or compromise any Proceeding or Tax
Claim without the prior  consent of the  Indemnitor  (which  consent will not be
unreasonably  withheld)  if such  settlement  or  compromise  will  result in an
obligation of the Indemnitor pursuant to this Agreement.

          (b) Agritope will not settle or compromise any Proceeding or Tax Claim
with respect to an Agritope  Group  Post-Closing  Return  (including an Agritope
Overlap Return)  involving a Tax period beginning  before the Distribution  Date
without the prior  consent of Epitope,  which  consent will not be  unreasonably
withheld.

          (c) A party  receiving a request for consent  pursuant to this Section
6.3 will  respond  as soon as  practicable  and in no event  after the tenth day
preceding the  expiration  of the period for appealing the  assessment or claim.
The  parties  will seek to resolve any  dispute  with  respect to such matter as
quickly as possible.  However, if the parties are unable to resolve such dispute
promptly, the matter will be referred to an Independent Firm for resolution.

7.    MISCELLANEOUS

     7.1 EFFECTIVENESS AND TERM. This Agreement will be effective from and after
the Distribution  Date and will survive until the later of (i) 90 days after the
expiration of any applicable  statute of  limitations  (including any waivers or
extensions)  related  to any  Taxes or  carryovers  of net  operating  losses or
credits to any  taxable  year or (ii) the final  conclusion  of any  Proceeding,
including  any  applicable  litigation  and appeals of any  liability for Taxes;
provided,  however,  that  this  Agreement  will  terminate  immediately  upon a
termination of the Separation Agreement.

                                       9
<PAGE>

     7.2 ENTIRE  AGREEMENT.  This Agreement  contains the entire agreement among
the parties with respect to the subject  matter.  This Agreement  terminates and
supersedes,  on a prospective  basis only, all Tax  agreements  (other than this
Agreement)  between  the  Epitope  Group  and the  Agritope  Group (or any other
predecessor).  However,  nothing in the preceding  sentence will limit or reduce
(i) the obligation of Agritope for Reserved  Taxes as separately  accrued on the
balance  sheet of the  Agritope  Group as of the  Distribution  Date or (ii) the
right of the Agritope Group to any Balance Sheet Refund.

     7.3  GOVERNING  LAW. This  Agreement  will be governed by and construed and
enforced in accordance  with the laws of the State of Oregon  (regardless of the
laws that might  otherwise  govern under  applicable  principles  of conflict of
laws) as to all matters,  including,  without  limitation,  matters of validity,
construction, effect, performance, and remedies.

     7.4  JURISDICTION AND VENUE.  Subject to the arbitration  provisions of the
Separation  Agreement,  each party consents to the personal  jurisdiction of the
state and federal  courts located in the State of Oregon and waives any argument
that venue in any such forum is not convenient or proper.

     7.5 NOTICES.  Notices under this Agreement  will be in writing,  will refer
specifically  to this  Agreement,  and  will be  personally  delivered,  sent by
electronic  facsimile  transmission  promptly  confirmed  by  mail,  or  sent by
registered or certified mail, return receipt requested, postage prepaid, in each
case to the  respective  address or facsimile  number  specified  below (or such
other address or number as may be specified by notice to the other party):

              If to Epitope:

              Epitope, Inc.
              8505 SW Creekside Place
              Beaverton, Oregon 97008
              Attention:  President
              Fax:  (503) 641-8665

              If to Agritope:

              Agritope, Inc.
              8505 SW Creekside Place
              Beaverton, Oregon  97008
              Attention:  President
              Fax:  (503) 520-6196

              Any notice or communication  given in conformity with this Section
7.5 will be deemed to be effective  when  received by the addressee if delivered
by hand or  electronic  facsimile  transmission,  or three days after mailing if
mailed.

                                       10
<PAGE>

     7.6 MODIFICATION OF AGREEMENT. No modification, amendment, or waiver of any
provision of this  Agreement  will be effective  unless in writing and signed by
each of the parties  and then such  modification,  amendment,  or waiver will be
effective only in the specific instance and for the purpose for which given.

     7.7 SUCCESSORS AND ASSIGNS.  A party's  rights and  obligations  under this
Agreement may not be assigned or transferred  without the prior written  consent
of the other party.  Subject to the  foregoing,  this  Agreement will be binding
upon and inure to the benefit of the parties,  the Epitope  Group,  the Agritope
Group,  and their respective  successors and permitted  assigns and will survive
any acquisition,  disposition,  or other corporate  restructuring or transaction
involving either party.

     7.8 NO THIRD-PARTY BENEFICIARIES.  This Agreement is solely for the benefit
of the parties to this  Agreement  and should not be deemed to confer upon third
parties any remedy, claim, liability,  reimbursement,  claim of action, or other
right in excess of those existing without this Agreement.

     7.9 TITLES AND  HEADINGS.  The titles and headings to Sections are inserted
for  convenience  of reference only and are not intended to constitute a part of
or to affect the meaning or interpretation  of this Agreement.  Unless otherwise
indicated, Section references are to the relevant Sections in this Agreement.

     7.10 SEVERABILITY.  In case any one or more of the provisions  contained in
this Agreement should be invalid, illegal, or unenforceable,  the enforceability
of the remaining provisions will in no way be affected or impaired.  If any such
term,  provision,  covenant,  or  restriction  is held to be invalid,  void,  or
unenforceable,  the  parties  will use their  best  efforts  to find and  employ
another  means to  achieve  the same or  substantially  the same  result as that
contemplated by such term, provision, covenant, or restriction.

     7.11 NO WAIVER.  Neither the failure nor any delay on the part of any party
to exercise any right under this  Agreement  will operate as a waiver,  nor will
any  single or  partial  exercise  of any right  preclude  any other or  further
exercise of the same or any other  right,  nor will any waiver of any right with
respect to any occurrence be construed as a waiver of such right with respect to
any other occurrence.

     7.12 SURVIVAL OF OBLIGATIONS. Notwithstanding anything in this Agreement or
the  Separation  Agreement  to the  contrary,  this  Agreement  will survive the
consummation of the  transactions  contemplated by the Separation  Agreement and
will continue throughout the period ending on the later of (i) 90 days after the
expiration of all applicable  statutes of limitation  (including  extensions) or
(ii) the final  determination  of (and the expiration of the time to appeal) any
Proceeding relating to Taxes or Tax matters covered by (or any claim under) this
Agreement and the payment of any corresponding obligation.

                                       11
<PAGE>

     7.13  COUNTERPARTS.   This  Agreement  may  be  executed  in  one  or  more
counterparts,  all of which will be considered one and the same  agreement,  and
will become a binding  agreement when one or more  counterparts have been signed
by each party and delivered to the other party.

       As evidence of their agreement, the parties have caused this Agreement to
be executed and delivered as of the date first written above.



EPITOPE, INC.                                   AGRITOPE, INC.

By: /s/ John W. Morgan                          By: /s/ Adolph J. Ferro
Its: President and                              Its: Chairman, President and
      Chief Executive Officer                         Chief Executive Officer




                                       12



                                   EXHIBIT 23


                       CONSENT OF INDEPENDENT ACCOUNTANTS


We  hereby  consent  to the  incorporation  by  reference  in  the  Prospectuses
constituting part of the Registration Statements on Forms S-3 (Numbers 33-68510,
33-67618,  33-57246,  33-52920,  33-42841,  33-39166,  and  33-32673),  and  the
Registration  Statements  on Forms S-8 (Numbers  33-63220,  33-63218,  33-41712,
33-13416,  33-21545,  33-82788, 33-63106, and 33-60789), of Epitope, Inc. of our
report  dated  October  31,  1997,  except  for Note 3 as to  which  the date is
December 1, 1997, appearing on page 24 of this Form 10-K.




Price Waterhouse LLP

Portland, Oregon
December 23, 1997


                                POWER OF ATTORNEY


                  KNOW  ALL  MEN  BY  THESE  PRESENTS  that  each  person  whose
signature  appears below  constitutes  and appoints  JOHN W. MORGAN,  GILBERT N.
MILLER, and each of them his true and lawful  attorneys-in-fact and agents, with
full power of  substitution  and  resubstitution  for the undersigned and in the
undersigned's  name,  place,  and stead, in any and all capacities,  to sign the
Annual Report on Form 10-K of Epitope, Inc., for its fiscal year ended September
30, 1997,  and any and all  amendments to the report and to file the same,  with
all exhibits  thereto,  and other  documents in connection  therewith,  with the
Securities and Exchange  Commission,  granting unto said  attorneys-in-fact  and
agents,  and each of them,  full power and  authority to do and perform each and
every act and thing  requisite and necessary to be done, as fully to all intents
and purposes as the undersigned  might or could do in person,  hereby  ratifying
and  confirming  all that said  attorneys-in-fact  and agents or each of them or
their or his  substitute or  substitutes  may lawfully do or cause to be done by
virtue hereof.

                  IN WITNESS WHEREOF,  this power of attorney has been signed by
the following persons in the capacities  indicated  effective as of December 19,
1997.

<TABLE>
         Name                Title                     Name                     Title
         ----                -----                     ----                     -----


<S>                          <C>                  <C>                           <C>
/s/ W. Charles Armstrong     Director             /s/ Douglas Norby             Director
W. Charles Armstrong                              R. Douglas Norby


/s/ Richard K. Donahue       Director             /s/ Michael J. Paxton         Director
Richard K. Donahue                                Michael J. Paxton


/s/ Adolph J. Ferro          Director             /s/ Roger L. Pringle          Director
Adolph J. Ferro, Ph.D.                            Roger L. Pringle


                             Director             /s/ G. Patrick Schaeffer      Director
Andrew S. Goldstein                               G. Patrick Schaeffer


                             Director
Margaret H. Jordan
</TABLE>



<TABLE> <S> <C>

<ARTICLE>                               5
<LEGEND>                                This schedule contains summary financial
                                        information extracted from the condensed
                                        consolidated     financial    statements
                                        included  herein and is qualified in its
                                        entirety by reference to such  financial
                                        statements.

</LEGEND>
       
<S>                               <C>
<PERIOD-TYPE>                     12-MOS
<FISCAL-YEAR-END>                 SEP-30-1996
<PERIOD-START>                    OCT-01-1996
<PERIOD-END>                      SEP-30-1997
<CASH>                              1,934,480
<SECURITIES>                        7,141,640
<RECEIVABLES>                         960,331
<ALLOWANCES>                          (32,284)
<INVENTORY>                         1,324,647
<CURRENT-ASSETS>                   11,536,003
<PP&E>                              5,470,702
<DEPRECIATION>                     (4,269,714)
<TOTAL-ASSETS>                     17,012,303
<CURRENT-LIABILITIES>               1,998,110
<BONDS>                                     0
                       0
                                 0
<COMMON>                          110,439,726
<OTHER-SE>                        (95,425,533)
<TOTAL-LIABILITY-AND-EQUITY>       17,012,303
<SALES>                             8,083,606
<TOTAL-REVENUES>                    9,360,060
<CGS>                               3,512,054
<TOTAL-COSTS>                       3,512,054
<OTHER-EXPENSES>                   10,811,549
<LOSS-PROVISION>                            0
<INTEREST-EXPENSE>                      8,165
<INCOME-PRETAX>                             0
<INCOME-TAX>                                0
<INCOME-CONTINUING>                (4,081,264)
<DISCONTINUED>                    (18,359,007)
<EXTRAORDINARY>                             0
<CHANGES>                                   0
<NET-INCOME>                      (22,440,271)
<EPS-PRIMARY>                           (1.67)
<EPS-DILUTED>                               0
        



</TABLE>


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