EPITOPE INC/OR/
DEF 14A, 2000-01-11
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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                           SCHEDULE 14A INFORMATION
Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934
(Amendment No.  )

Filed by the Registrant [x]
Filed by a Party other than the Registrant [ ]

Check the appropriate box:
[ ] Preliminary Proxy Statement          [ ] Confidential, for Use of
[x] Definitive Proxy Statement                 the Commission Only (as
[ ] Definitive Additional Materials            permitted by
[ ] Soliciting Material Pursuant to            Rule 14a-6(e)(2))
            Rule 14a-11(c)
            or Rule 14a-12

                                  Epitope, Inc.
- --------------------------------------------------------------------------------
                (Name of Registrant as Specified In Its Charter)

- --------------------------------------------------------------------------------
    (Name of  Person(s)  Filing Proxy  Statement  if other than the  Registrant)

Payment of Filing Fee (Check the appropriate box):
[x] No fee required.
[ ] Fee computed on table below per Exchange Act Rules 14a-6(i)(1) and 0-11.

    1)  Title of each class of securities to which transaction applies:

- --------------------------------------------------------------------------------
    2)  Aggregate number of securities to which transaction applies:

- --------------------------------------------------------------------------------
    3)  Per unit  price  or  other  underlying  value  of  transaction  computed
    pursuant to Exchange Act Rule 0-11 (set forth the amount on which the filing
    fee is calculated and state how it was determined):

- --------------------------------------------------------------------------------
    4)  Proposed maximum aggregate value of transaction:

- --------------------------------------------------------------------------------
    5)  Total fee paid:

- --------------------------------------------------------------------------------

[ ] Fee paid previously with preliminary materials.

[ ] Check box if any part of the fee is offset as provided by Exchange  Act Rule
0-11(a)(2)  and  identify  the  filing  for  which the  offsetting  fee was paid
previously.  Identify the previous filing by registration  statement  number, or
the form or schedule and the date of its filing.

    1)  Amount Previously Paid:

- --------------------------------------------------------------------------------
    2)  Form, Schedule or Registration Statement No.:

- --------------------------------------------------------------------------------
    3)  Filing Party:

- --------------------------------------------------------------------------------
    4)  Date Filed:

- --------------------------------------------------------------------------------
<PAGE>
                            [Graphic: Epitope logo]

                                  EPITOPE, INC.
                            8505 S.W. Creekside Place
                             Beaverton, Oregon 97008


                                                                January 11, 2000

Dear Shareholder:

         You are  cordially  invited  to  attend  the  2000  Annual  Meeting  of
Shareholders to be held on TUESDAY,  FEBRUARY 15, 2000, at the Oregon Convention
Center,  777 N.E. Martin Luther King Jr.  Boulevard,  Portland,  Oregon, at 9:00
a.m. Your Board of Directors and management look forward to personally  greeting
those  present.  At the  meeting,  you will be asked to (i) elect  three Class I
directors  to serve on the  Board of  Directors  until  the  Annual  Meeting  of
Shareholders  in 2003 and one  Class  III  director  to  serve  on the  Board of
Directors  until the Annual Meeting of  Shareholders  in 2001; (ii) consider and
vote on a  proposal  to  approve a new  employee  stock  award  plan;  and (iii)
transact  such other  business  as may  properly  come before the meeting or any
adjournments thereof.

         Your  Board  of  Directors  unanimously  recommends  that  you vote FOR
adoption of the new stock award plan.  In addition,  the Board of Directors  has
approved  the  nominees  for  director  and  recommends  that you vote FOR their
election to the board.

         Your vote is very  important,  regardless  of the  number of shares you
own. Whether or not you plan to attend the Annual Meeting in person, we urge you
to  mark,  sign,  date,  and  mail  the  enclosed  proxy  card  promptly  in the
accompanying  postage prepaid  envelope.  You may, of course,  attend the Annual
Meeting and vote in person even if you have previously mailed your proxy card.


Sincerely yours,

/s/ Charles E. Bergeron

Charles E. Bergeron
Interim President and Chief Financial Officer

<PAGE>
                            [Graphic: Epitope logo]

                                  EPITOPE, INC.
                            8505 S.W. Creekside Place
                             Beaverton, Oregon 97008
                                 ---------------

                    NOTICE OF ANNUAL MEETING OF SHAREHOLDERS
                          TO BE HELD FEBRUARY 15, 2000
                                 --------------

To the Shareholders of Epitope, Inc.:


         The  Annual  Meeting  of  Shareholders  of  Epitope,  Inc.,  an  Oregon
corporation,  will be held at the  Oregon  Convention  Center,  777 N.E.  Martin
Luther King Jr.  Boulevard,  Portland,  Oregon 97232,  on TUESDAY,  FEBRUARY 15,
2000, at 9:00 a.m. for the following purposes:

1.       To elect three Class I directors and one Class III director;

2.       To  consider  and vote on a proposal  to approve a new  employee  stock
award plan to be called the "Epitope, Inc. 2000 Stock Award Plan"; and

3.       To consider such other business as may properly come before the meeting
or any adjournment thereof.

         Additional  information is included in the proxy statement accompanying
this notice.  Only holders of Common Stock of record at the close of business on
December  15,  1999,  will  be  entitled  to  vote  at  the  Annual  Meeting  of
Shareholders and any adjournments thereof.

By Order of the Board of Directors


Andrew S. Goldstein
Secretary


January 11, 2000
Beaverton, Oregon



- --------------------------------------------------------------------------------

YOUR VOTE IS IMPORTANT.  WHETHER OR NOT YOU PLAN TO ATTEND THE MEETING,  YOU ARE
URGED TO MARK,  SIGN,  DATE,  AND  RETURN THE  ENCLOSED  PROXY  PROMPTLY  IN THE
ENVELOPE  PROVIDED.  RETURNING  YOUR PROXY DOES NOT DEPRIVE YOU OF YOUR RIGHT TO
ATTEND THE MEETING AND TO VOTE YOUR SHARES IN PERSON.

- --------------------------------------------------------------------------------

<PAGE>

                                  EPITOPE, INC.
                            8505 S.W. Creekside Place
                             Beaverton, Oregon 97008

                                   -----------


                                 PROXY STATEMENT

This  proxy  statement  is  being  mailed  on or  about  January  11,  2000,  to
shareholders  of  Epitope,  Inc.,  an Oregon  corporation  (the  "Company"),  in
connection with the  solicitation  of proxies  ("Proxies") for use at the Annual
Meeting of  Shareholders  to be held on February 15, 2000,  at 9:00 a.m., at the
Oregon Convention Center,  777 N.E. Martin Luther King Jr. Boulevard,  Portland,
Oregon 97232, and at any adjournments thereof (the "Annual Meeting").


                                     PROXIES

Shares represented by a properly executed Proxy will be voted in accordance with
the shareholder's instructions.  If no instructions are given, the shareholder's
shares will be voted according to the  recommendations of the Board of Directors
(the  "Board")  as stated on the Proxy.  Shareholders  may revoke the  authority
granted  by their  Proxies at any time  before  the Annual  Meeting by notice in
writing delivered to the Secretary of the Company,  by submitting a subsequently
dated Proxy,  or by attending the Annual  Meeting,  withdrawing  the Proxy,  and
voting in person.

At the Annual  Meeting,  action  will be taken on the  matters  set forth in the
accompanying  Notice of Annual  Meeting of  Shareholders  and  described in this
proxy statement.  The Board knows of no other matters to be presented for action
at the Annual  Meeting.  If any other matters do properly come before the Annual
Meeting,  the persons  named on the Proxy will have  discretionary  authority to
vote thereon in accordance with their best judgment.

The cost of  soliciting  Proxies  will be borne by the  Company.  In addition to
solicitations by mail, certain of the Company's directors, officers, and regular
employees may solicit Proxies  personally or by telephone or other means without
additional  compensation.  The Company has retained  D.F.  King & Co.,  Inc., to
assist in such  solicitation  for an estimated fee of $4,500 plus  reimbursement
for certain expenses.

Arrangements  will also be made  with  brokerage  firms  and  other  custodians,
nominees,  and  fiduciaries to forward  solicitation  material to the beneficial
owners of stock  held of record by such  persons,  and the  Company  will,  upon
request, reimburse them for their reasonable expenses in so doing.





- --------------------------------------------------------------------------------

  PLEASE MARK, SIGN, AND DATE THE ENCLOSED PROXY CARD, AND RETURN IT PROMPTLY
              IN THE ENCLOSED ENVELOPE PROVIDED FOR THIS PURPOSE.

- --------------------------------------------------------------------------------

                                                                   EPITOPE, INC.
                                                                               1
<PAGE>

                                VOTING SECURITIES

On December 15, 1999, the record date for determining  shareholders  entitled to
vote at the Annual Meeting,  the Company had outstanding and entitled to vote at
the meeting  14,248,425  shares of Common Stock, no par value ("Common  Stock").
Each share of Common Stock is entitled to one vote on any matter  brought before
the  meeting.  A majority of the shares of Common  Stock  outstanding  as of the
record date, represented in person or by proxy at the meeting, will constitute a
quorum for the transaction of business.

                             PRINCIPAL SHAREHOLDERS

The following  table sets forth  information as of December 15, 1999,  regarding
the beneficial ownership of the Company's Common Stock by (a) each person who is
known to the  Company to be the  beneficial  owner of more than 5 percent of the
Common  Stock  outstanding,  (b) each  director  and  nominee  for  election  as
director,  (c) each of the  Company's  executive  officers  named in the Summary
Compensation  Table under  EXECUTIVE  COMPENSATION,  and (d) all  directors  and
executive officers of the Company as a group.

                              Amount and Nature of                       Percent
Beneficial Owner             Beneficial Ownership (1)(2)                of Class
- --------------------------------------------------------------------------------
Sawtooth Partners, L.P.                  2,115,850(3)                      14.8%
Sawtooth Capital Management, Inc.
Sawtooth Capital Management, L.P.
100 Wilshire Blvd., 15th Floor
Santa Monica, CA 90401

W. Charles Armstrong                        89,705(4)                          *

Charles E. Bergeron                        169,897(4)                       1.2%

William D. Block                             7,443                            *

J. Richard George, Ph.D.                    71,315(4)                         *

Andrew S. Goldstein                        438,659                          3.1%

Frank G. Hausmann                                -                             *

Margaret H. Jordan                          51,000                            *

John W. Morgan                             275,117(4)                       1.9%

Michael J. Paxton                           72,052                            *

Roger L. Pringle                           152,177(4)                       1.1%

G. Patrick Sheaffer                         95,000                            *

Robert J. Zollars                           20,000                            *

All directors and executive              1,442,365(4)                      10.1%
officers as a group (11 persons)
- ---------
*Less than 1%

(1)      Subject  to  community  property  laws  where  applicable,   beneficial
         ownership  consists  of sole  voting and  dispositive  power  except as
         otherwise indicated.


EPITOPE, INC.
2
<PAGE>


(2)      Includes  shares  subject  to  options  exercisable  within  60 days of
         December  15, 1999,  as follows:  Mr.  Armstrong,  85,000  shares;  Mr.
         Bergeron,  164,208 shares;  Dr. George,  68,708 shares;  Mr. Goldstein,
         212,750 shares; Ms. Jordan, 50,000 shares; Mr. Morgan,  264,576 shares;
         Mr. Paxton,  70,552 shares; Mr. Pringle,  115,552 shares; Mr. Sheaffer,
         82,500  shares;  Mr.  Zollars,  20,000  shares;  and all  directors and
         executive officers as a group, 1,133,846 shares.

(3)      Sawtooth  Partners,  L.P. has sole voting and  dispositive  power as to
         1,784,660  shares.  Sawtooth  Capital  Management,  Inc., as investment
         advisor to Sawtooth  Offshore Limited  investment fund, has sole voting
         and  dispositive  power as to  148,890  shares,  and  Sawtooth  Capital
         Management,  L.P.,  as  investment  advisor to Polaris  Prime Small Cap
         Value Fund, has sole voting and dispositive power as to 182,300 shares.
         Sawtooth  Capital  Management,  Inc.  is general  partner  of  Sawtooth
         Capital Management,  L.P., which in turn is general partner of Sawtooth
         Partners, L.P.

(4)      Includes  shares as to which  the  individual  has  shared  voting  and
         dispositive power as follows: Mr. Armstrong,  165 shares; Mr. Bergeron,
         2,153 shares; Dr. George,  1,000 shares; Mr. Morgan,  5,000 shares; Mr.
         Pringle,  1,500 shares;  and all directors and executive  officers as a
         group, 9,818 shares.

             SECTION 16(A) BENEFICIAL OWNERSHIP REPORTING COMPLIANCE

Section  16(a) of the  Securities  Exchange Act of 1934  requires the  Company's
officers  and  directors  and persons who own more than 10 percent of the Common
Stock  (collectively,  "Reporting  Persons") to file  reports of  ownership  and
changes  in  ownership  with  the  Securities  and  Exchange   Commission   (the
"Commission"). Reporting persons are required by the Commission's regulations to
furnish the Company with copies of all Section 16(a) forms they file.

Based   solely  on  its  review  of  the  copies  of  such  forms  and   written
representations  regarding  the absence of a filing  requirement  received  from
Reporting  Persons,  the Company  believes  that with respect to the 1999 fiscal
year, all Reporting Persons complied with all applicable filing requirements.

ITEM 1                        ELECTION OF DIRECTORS

At the Annual Meeting,  shareholders  will vote on the election of three Class I
directors and one Class III director.  The Nominating Committee of the Board has
nominated  W.  Charles  Armstrong,  John W.  Morgan,  and Roger L.  Pringle  for
election  as Class I  directors,  for terms  expiring  at the Annual  Meeting of
Shareholders  in 2003,  and  Frank  G.  Hausmann  for  election  as a Class  III
director, for a term expiring at the Annual Meeting of Shareholders in 2001. The
nominees for election as directors are presently members of the Board.

In the  absence  of  instructions  to  the  contrary,  shares  of  Common  Stock
represented  by properly  executed  Proxies will be voted for the four nominees,
each of whom has  consented to be named and to serve if elected.  If a quorum is
present,  each  nominee will be elected if he or she receives a plurality of the
votes cast by shares  entitled to vote at the Annual  Meeting.  Abstentions  and
shares as to which a broker or other  nominee has  indicated on a duly  executed
and  returned  proxy or  otherwise  advised  the  Company  that it lacks  voting
authority will have no effect on the required vote.

The  Company  does not know of anything  that would  preclude  any nominee  from
serving.  However,  should any nominee for any reason become unable or unwilling
to serve as a director,  the persons  named in the enclosed  Proxy will vote the
shares  represented by each Proxy for such  substitute  nominee as the Board may
approve.

Any  vacancy  that  occurs  during the term of a  director  may be filled by the
affirmative vote of a majority of the remaining  directors even though less than
a quorum of the Board.  The vacancy may be filled until the next annual  meeting
of shareholders.  Mr. Hausmann was elected to the Board on December 21, 1999, to
fill a vacancy  that  occurred  upon the  resignation  of Richard K.  Donahue in
February 1998.


                                                                   EPITOPE, INC.
                                                                               3
<PAGE>

Certain  information  with  respect to each person  nominated  for election as a
director and each person whose term of office as a director will continue  after
the Annual Meeting is set forth below.

                                                                        Director
Name                  Principal Occupation                        Age    Since
- --------------------------------------------------------------------------------
Class I (Nominees for Terms of Office to Expire in 2003):
- --------------------------------------------------------

W. Charles Armstrong  Former Chairman and Chief Executive          55     1989
                      Officer of Bank of America Oregon

John W. Morgan        President and Chief Executive Officer        40     1998
                      of Conway Stuart Medical, Inc., a developer
                      of treatments for digestive system disorders

Roger L. Pringle      President of The Pringle Company,            59    1989
                      a management consulting firm

Class II  (Directors Whose Terms of Office Expire in 2002):
- ----------------------------------------------------------

Andrew S. Goldstein   Senior Vice President of Advanced            51    1981
                      Technology Development of the
                      Company

G. Patrick Sheaffer   Chairman, President and Chief                60    1983
                      Executive Officer of Riverview
                      Community Bank

Robert J. Zollars     Chairman, President and                      42    1998
                      Chief Executive Officer of
                      Neoforma.com, Inc., an e-commerce
                      procurement company for health care
                      providers

Class III  (Nominee and Directors Whose Terms of Office Expire in 2001):
- -----------------------------------------------------------------------

Frank G. Hausmann     President and Chief Executive Officer of     42    1999
                      CenterSpan Communications Corporation,
                      a  provider  of  Internet   voice  and  text
                      messaging  software  designed  primarily for
                      use with interactive games

Margaret H. Jordan    President of The Margaret Jordan             57    1995
                      Group, L.L.C., a management consulting
                      firm for the health care industry

Michael J. Paxton     President of First Alert, Inc., a division   53    1995
                      of Sunbeam Corporation that manufactures
                      and distributes residential safety equipment

W. Charles Armstrong,  now a private investor and consultant,  served as interim
President  and Chief  Executive  Officer of the Company from May 1997 to October
1997. He was Chairman and Chief Executive Officer of Bank of America Oregon from
September 1992 until  September  1996. Mr.  Armstrong is a director of Agritope,
Inc., which was a subsidiary of the Company until its spin-off in December 1997,
and served on the board of Pacificorp, Inc. until December 1999.

Andrew S. Goldstein is Senior Vice  President of the Company,  a position he has
held since June 1990.  Prior to that time, he had been Vice President of Product
Development  from December 1988, Vice President of Scientific  Affairs from July
1987 to December 1988, and Vice President of Research and Development  from 1981
until July 1987. He also has served as Secretary  from December 1988 to February
1993 and from November 1995 to the present and served

EPITOPE, INC.
4
<PAGE>

as  Treasurer  until  March 1991.  Mr.  Goldstein  was  Research  Associate  and
supervisor of the  Histocompatibility  Laboratory at the Oregon Health  Sciences
University   ("OHSU"),   where  he  was   engaged  in   paternity   testing  and
transplantation  immunology,  from 1974 to 1981. Mr.  Goldstein  received a B.S.
degree in  microbiology  from Cornell  University  in 1969 and a M.S.  degree in
cytology from Fordham University in 1973.

Frank G.  Hausmann has been employed by  CenterSpan  Communications  Corporation
(formerly  known  as  Thrustmaster,  Inc.)  since  July  1998  and has  been its
President  and Chief  Executive  Officer  since  October 1998. He served as Vice
President,  Finance and Administration and Chief Financial Officer prior to that
time.  From  August 1997 to May 1998,  Mr.  Hausmann  served as Vice  President,
Finance and Chief  Financial  Officer of Atlas  Telecom,  Inc.,  a developer  of
enhanced  facsimile and voice-mail  solutions,  that was experiencing  financial
difficulties  and engaged Mr. Hausmann as part of its efforts to turn around the
company. In May 1998, an involuntary bankruptcy case was commenced against Atlas
Telecom.  From  September  1995 to  July  1997,  he  served  as Vice  President,
Corporate Development and General Counsel of Diamond Multimedia Systems, Inc., a
designer  and marketer of computer  peripherals  such as modems and graphics and
sound cards.  Mr.  Hausmann  received  B.S.  degrees in economics  and political
science from  Willamette  University  and a J.D.  degree from the  University of
Oregon.  He is a member of the Oregon State Bar. Mr. Hausmann is also a director
of CenterSpan Communications Corporation.

Margaret H. Jordan has been President of The Margaret  Jordan Group,  L.L.C.,  a
management  consulting  firm for the health care  organization  industry,  since
October 1997. Prior to that time, she was President and Chief Executive  Officer
of  Dallas  Medical  Resource  ("DMR")  beginning  in  February  1996.  DMR is a
not-for-profit  alliance of Dallas' major medical organizations that was created
to make Dallas, Texas, a regional, national and international center for medical
referrals.  Ms. Jordan was Vice President of Health Care & Employee  Services at
Southern California Edison Co. from December 1992 until January 1996. Ms. Jordan
received a B.S. degree in nursing from Georgetown University in 1964 and an M.S.
degree in public health from the University of California, Berkeley in 1972. She
also serves on the Board of Directors of Eckerd Corporation.

John W. Morgan has been President and Chief  Executive  Officer of Conway Stuart
Medical,  Inc. since November 1999. He was President and Chief Executive Officer
of the Company from October 1997 until his  resignation in October 1999.  Before
joining the Company, he was  President-Americas of Regent Medical Products Group
since 1996.  Prior to joining  Regent,  he held  various  positions  with Baxter
Healthcare Corporation, where he worked for 13 years. Mr. Morgan received a B.S.
degree in public  administration and economics from the University of Arizona in
1982.  Mr. Morgan  serves on the boards of directors of Conway  Stuart  Medical,
Inc., and Koch Supply, Inc.

Michael J. Paxton became  President of First Alert,  Inc., a division of Sunbeam
Corporation,  in August 1998. He was  previously  Chairman,  President and Chief
Executive  Officer of O'Cedar  Holdings,  Inc.,  beginning in January 1996. From
March 1992 until  joining  O'Cedar  Holdings,  Inc.,  he was President and Chief
Executive  Officer of The  Haagen-Dazs  Company,  Inc.,  a  subsidiary  of Grand
Metropolitan  PLC. He is also a director of  Transport  Corporation  of America,
Inc.

Roger L. Pringle has been Chairman of the Board of the Company since April 1990.
He is  President  of The  Pringle  Company,  a  management  consulting  firm  in
Portland,  Oregon,  which he founded in 1975.  Mr. Pringle is also a director of
Agritope, Inc., and Bank of the Northwest.

G. Patrick  Sheaffer has been  President of Riverview  Community  Bank in Camas,
Washington,  since 1979, and has served as a director of the bank since 1983. In
1993, Mr. Sheaffer also became Chairman and Chief Executive Officer of Riverview
Community Bank and Riverview Bancorp, a bank holding company.  In December 1998,
Mr. Sheaffer became Chairman of Riverview Asset  Management,  Inc., a bank trust
company.

Robert J. Zollars has been Chairman,  President and Chief  Executive  Officer of
Neoforma.com,  Inc.,  since  July 1,  1999.  He was  previously  Executive  Vice
President and Group  President of Cardinal  Health,  Inc.,  beginning in January
1997.  Prior to that, he served in various  positions as a corporate  officer of
Baxter  Healthcare  Corporation,  most recently as President of Hospital Supply,
Scientific Products,  and U.S.  Distribution.  Baxter Healthcare was spun off as
Allegiance  Corporation  in October  1996.  Mr.  Zollars  has nearly 20 years of
health care industry experience.  Mr. Zollars received a M.B.A. degree from John
F.  Kennedy  University  and a B.S.  degree  in  marketing  from  Arizona  State
University.

                                                                   EPITOPE, INC.
                                                                               5
<PAGE>

                               DIRECTORS' MEETINGS

The Board held 12 meetings  during the fiscal year ended September 30, 1999. Mr.
Hausmann was not a director until after the end of the fiscal year.  Each of the
other directors listed above attended more than 75 percent of the combined total
of meetings of the Board and of  committees  of the Board on which the  director
served during the year.

                             COMMITTEES OF THE BOARD

EXECUTIVE  COMMITTEE.  The Board has designated an Executive Committee to assist
in the discharge of the Board's  responsibilities.  The  Executive  Committee is
composed of four directors,  Roger L. Pringle,  Chairman,  W. Charles Armstrong,
John W. Morgan,  and Michael J. Paxton.  The  Executive  Committee  did not meet
during the fiscal year ended  September 30, 1999.  The  Executive  Committee may
exercise  all the  authority  and powers of the Board in the  management  of the
business and affairs of the Company,  except those  reserved to the Board by the
Oregon Business Corporation Act or the Company's bylaws.

EXECUTIVE  COMPENSATION  COMMITTEE.  The Executive Compensation Committee of the
Board  establishes  and reviews  from time to time  compensation  for  executive
officers  of the  Company,  administers  the  Company's  stock  award  plans and
employee stock purchase plans, and performs other tasks as the Board may direct.
Members  of the  Executive  Compensation  Committee  are W.  Charles  Armstrong,
Chairman, G. Patrick Sheaffer, and Robert J. Zollars. The Executive Compensation
Committee met 11 times during the fiscal year ended September 30, 1999.

AUDIT  COMMITTEE.  The Audit  Committee of the Board reviews the performance and
independence of the Company's outside  auditors.  Members of the Audit Committee
are G. Patrick Sheaffer, Chairman, Margaret H. Jordan, and Roger L. Pringle. The
Audit Committee met twice during fiscal 1999. The Audit Committee recommended to
the  Board of  Directors  that no change  be made  with  regard  to the  outside
auditors and that no significant changes in the Company's  accounting  practices
were necessary.

NOMINATING  COMMITTEE.  The  Nominating  Committee  of the  Board  solicits  and
recommends  potential  candidates for membership on the Board of Directors.  The
members of the Nominating  Committee are Roger L. Pringle,  Chairman,  Andrew S.
Goldstein,  Margaret H. Jordan and John W. Morgan. The Nominating  Committee met
once during fiscal 1999.

The Nominating  Committee will consider  nominees  recommended by  shareholders.
Shareholders   wishing  to  recommend  a  candidate  for  consideration  by  the
Nominating Committee should submit information about the candidate in writing to
the  Company at the  address  and by the  deadline  stated  under  DEADLINE  FOR
SHAREHOLDER PROPOSALS.

The Company's  Bylaws provide that  nominations for election to the Board may be
made by the Board or by any  shareholder  entitled  to vote for the  election of
directors.  Notice of a  shareholder's  intent to make such a nomination must be
given in writing,  by personal delivery or certified mail,  postage prepaid,  to
the  Secretary  of the  Company  and must  include  the name and  address of the
shareholder and each proposed nominee, a representation  that the shareholder is
a record  holder of Common  Stock and intends to appear in person or by proxy at
the  shareholder  meeting to  nominate  the person or persons  specified  in the
notice,  a description of any arrangements or  understandings  pursuant to which
the nominations are to be made, the consent of each proposed nominee to serve as
a director if elected,  and such other  information  regarding  each  nominee as
would be required to be included in the Company's proxy statement had the person
been nominated by the Board. Such notice, with respect to an election to be held
at an annual meeting of shareholders,  must be given at least 60 days in advance
of the  anniversary  of the  date  of the  previous  year's  annual  meeting  of
shareholders  or,  with  respect  to  an  election  to  be  held  at  a  special
shareholders  meeting,  must be given no later than the close of business on the
seventh day  following  the date on which notice of such meeting was first given
to shareholders.

EPITOPE, INC.
6
<PAGE>

                               EXECUTIVE OFFICERS

The table below gives information about the executive officers of the Company as
of December 15, 1999.

     Name                      Age                       Position
- --------------------------------------------------------------------------------

Charles E. Bergeron            54                Interim President and Chief
                                                 Financial Officer

William D. Block               38                Vice President of Sales
                                                 and Marketing

J. Richard George, Ph.D.       58                Chief Scientific Officer

Andrew S. Goldstein            51                Senior Vice President of
                                                 Advanced Technology
                                                 Development, Secretary
                                                 and Director

Officers of the Company hold office at the discretion of the Board.

Charles E.  Bergeron  has been Chief  Financial  Officer  of the  Company  since
January  1998 and  Interim  President  since  October  1999.  He served as Chief
Financial  Officer of Epitope  Medical  Products from  September 1997 to January
1998 at which  point he became  Chief  Financial  Officer for the  Company.  Mr.
Bergeron  joined the Company in August  1993 as  President  and Chief  Executive
Officer,  Agrimax Floral Products,  Inc., then a wholly-owned  subsidiary.  From
1978 to 1992, Mr.  Bergeron was Senior Vice President - Finance of  Freightliner
Corporation, a Portland,  Oregon, truck manufacturer.  He holds a B.S. degree in
management  engineering  and M.S.  degree in management  science from Rensselaer
Polytechnic Institute, and a M.B.A. degree from Columbia University.

William D. Block has been Vice President of Sales and Marketing  since May 1999.
Before  joining  the  Company,  he  was  Director  of  Institutional  Sales  for
McKessonAPS,  a division of  McKessonHBOC,  since  March 1997.  Prior to joining
McKessonAPS, Mr. Block held various positions with Baxter International,  Inc.'s
subsidiary  Allegiance  Corporation,  where he worked  for six  years.  His last
position with Allegiance was as a Senior Account Manager/General Manager for the
MidAmerica  region where he oversaw sales of medical products and supplies.  Mr.
Block is an Army ROTC graduate from Wake Forest  University  where he received a
B.A. degree in economics in 1983.

J. Richard George, Ph.D., has been Chief Scientific Officer of the Company since
January  1998. He joined the Company as Vice  President of Scientific  Affairs -
Epitope  Medical  Products  in  March  1995.  A  career  scientist,  Dr.  George
previously  served with the Centers for Disease Control and Prevention  ("CDC"),
Atlanta,  Georgia,  which he joined in 1960. He held a series of management  and
technical  positions  at the  CDC,  becoming  Chief,  Developmental  Technology,
Laboratory  Investigations  Branch,  Division of HIV/AIDS in 1988. He holds B.S.
and M.S. degrees from Georgia State University and a Ph.D. in microbiology  from
the University of Georgia.

For a biographical summary of  Mr. Goldstein, see ELECTION OF DIRECTORS.

                                                                   EPITOPE, INC.
                                                                               7
<PAGE>

                             EXECUTIVE COMPENSATION

SUMMARY COMPENSATION TABLE

The following table summarizes the compensation of the Company's Chief Executive
Officer and the four other most highly compensated  individuals who were serving
as executive officers of the Company at September 30, 1999.
<TABLE>
<S>              <C>                    <C>           <C>         <C>              <C>              <C>

                                                    Annual         Long-Term Compensation
                                                    Compen-                Awards
                                                    sation     --------------------------------
                                                                                 Securities
                                                                Restricted       Underlying       All Other
Name and Principal Position              Year       Salary      Stock Awards     Options (#)(1)   Compensation (2)
- ------------------------------------------------------------------------------------------------------------------
Charles E. Bergeron (3)                 1999        $155,769   $       -            60,000        $       -
Interim President and Chief             1998         150,129           -            30,000                -
Financial Officer                       1997         129,567           -           134,000(4)             -

William D. Block (5)                    1999          49,038      29,996           112,500           58,725(6)
Vice President of Sales
and Marketing

J. Richard George, Ph.D.                1999         145,385           -            55,000            3,384
Chief Scientific Officer                1998         130,000           -            30,000            2,406
                                        1997         128,654           -            70,000(4)         3,250
Andrew S. Goldstein                     1999         153,846           -            35,000            2,957
Senior Vice President of                1998         150,000           -            25,000            3,653
Advanced Technology                     1997         149,163           -            94,000(4)         3,750
Development

John W. Morgan (7)                      1999         245,000           -            75,000            8,867(8)
Former President and Chief              1998         238,404           -           350,000           61,071(6)
Executive Officer

</TABLE>

(1)      Represents  the number of shares for which  options  were  awarded.  No
         stock  appreciation  rights  ("SARs")  have been  granted  to any named
         executive officer during the years presented.

(2)      Except as  otherwise  noted in (6) and (8)  below,  represents  amounts
         contributed  to the Company's  401(k)  Profit  Sharing Plan as employer
         matching contributions in the form of Common Stock.

(3)      Mr.  Bergeron  began  serving as Interim  President in October 1999, in
         connection  with the  resignation  of Mr. Morgan as President and Chief
         Executive Officer.

(4)      Option grants during fiscal year 1997 consisted of replacement  options
         granted to effect the repricing of outstanding options.

(5)      Mr.  Block joined the Company in May 1999.  At December  15, 1999,  Mr.
         Block held 6,233 shares of restricted  Common Stock with a dollar value
         of $29,996,  subject to future  vesting or  forfeiture.  The restricted
         shares vest in full on the first anniversary of Mr. Block's  employment
         date.

(6)      Includes $57,488 and $57,307 in relocation  expenses for Mr. Morgan and
         Mr. Block,  respectively,  reimbursed by the Company,  including moving
         costs,  realtor fees,  closing costs,  furniture  storage costs,  other
         miscellaneous  expenses,  and federal and state income taxes on amounts
         paid as expense reimbursement.

(7)      Mr. Morgan joined the Company in October 1997. He resigned as President
         and Chief Executive Officer of the Company effective October 31, 1999.

(8)      Includes  $3,770  in term life  insurance  premiums  reimbursed  to Mr.
         Morgan in 1999.

EPITOPE, INC.
8
<PAGE>

OPTION GRANTS IN THE LAST FISCAL YEAR
<TABLE>
<S>                          <C>              <C>          <C>        <C>      <C>  <C>               <C>         <C>
                                             Individual Grants (1)

                                         Percent of                                       Potential Realizable Value at
                                            Total                                            Assumed Annual Rates of
                             Number of     Options                                                 Stock Price
                            Securities   Granted to              Market                 Appreciation for Option Term (2)
                                                                                        --------------------------------
                            Underlying    Employees   Exercise   Price on   Expir-
                              Options     in Fiscal   Price      Date of     ation
           Name               Granted       Year      Per Share    Grant      Date         0%          5%         10%
- -------------------------------------------------------------------------------------------------------------------------

  Charles E. Bergeron         30,000         4.88%      $3.22      $3.22    10/20/08      $   -     $60,729    $153,898
                              30,000         4.88%       6.84       6.84     9/21/09          -     129,121     327,218
  William D. Block           100,000        16.27%       4.81       4.81     5/16/09          -     302,656     766,989
                              12,500         2.03%       6.84       6.84     9/21/09          -      53,800     136,341
  J. Richard George           30,000         4.88%       3.22       3.22    10/20/08          -      60,729     153,898
                              25,000         4.07%       6.84       6.84     9/21/09          -     107,601     272,681
  Andrew S. Goldstein         20,000         3.25%       3.22       3.22    10/20/08          -      40,486     102,599
                              15,000         2.44%       6.84       6.84     9/21/09          -      64,560     163,609
  John W. Morgan              75,000(3)     12.20%       2.41       3.22    10/20/08     60,353     212,174     445,098

</TABLE>

(1)      Except as otherwise noted or as required by law,  options are qualified
         as incentive stock options and vest as to one-fourth one year after the
         date of grant,  with the  remaining  three-fourths  vesting  in monthly
         installments  over the  following  36  months.  Vesting  ceases 90 days
         following  termination  of employment  and is  accelerated in case of a
         change in control of the Company.  The  holder's  right to exercise the
         options will terminate  immediately  upon termination of employment for
         cause,  will expire five years  after  retirement,  and will expire one
         year after death,  disability,  or ceasing to be an active  employee of
         the Company for any other reason.  Subject to certain  conditions,  the
         exercise  price of the options  may be paid by  delivery of  previously
         acquired  shares of Common  Stock.  No SARs were granted  during fiscal
         1999.

(2)      The amounts shown are hypothetical gains based on the indicated assumed
         rates of  appreciation  of the Common Stock  compounded  annually for a
         ten-year  period.  There can be no assurance that the Common Stock will
         appreciate in value at any particular rate or at all in future years.

(3)      Vests as to  one-third  one year  after  the  date of  grant,  with the
         remaining  two-thirds  vesting in equal monthly  installments  over the
         following 24 months. Option is a nonqualified stock option.


                                                                   EPITOPE, INC.
                                                                               9
<PAGE>

FISCAL YEAR-END OPTION  VALUES (1)
<TABLE>
<S>                                            <C>                 <C>                   <C>                <C>

                                        Number of Securities Underlying           Value of Unexercised In-the-
                                         Unexercised Options at Fiscal            Money Options at Fiscal Year-
                                                    Year-End                                   End (2)
                                       -----------------------------------       ------------------------------------
                Name                     Exercisable      Unexercisable            Exercisable       Unexercisable
- ---------------------------------------------------------------------------------------------------------------------

Charles E. Bergeron                            150,666             73,334                $225,325           $122,187

William D. Block                                     -            112,500                       -            168,750

J. Richard George                               50,166             73,334                  74,902            129,487

Andrew S. Goldstein                            203,896             50,104                 375,688             73,176

John  W. Morgan                                223,605            201,395                 747,466            728,956
</TABLE>

(1)      The named  executive  officers  neither  exercised  any options or SARs
         during fiscal 1999 nor held any SARs at September 30, 1999.

(2)      In-the-money  stock options are options for which the exercise price is
         less than the  market  value of the  underlying  stock on a  particular
         date. The values shown in the table are based on the difference between
         $6.50,  which was the  average of the high and low sales  prices of the
         Common  Stock as quoted on The Nasdaq  Stock  Market on  September  30,
         1999, and the applicable exercise price.

EMPLOYMENT AGREEMENTS

Pursuant  to  written  employment  agreements  with  the  Company,  all  current
executive  officers  are  entitled to receive one year of salary in the event of
termination  without  cause  (two  years  in  the  case  of  Mr.  Goldstein  for
termination  in  connection  with a  change  in  control  of the  Company).  The
agreements with Messrs. Bergeron and Block permit each of them to treat a change
in  control  and  certain  other  events as a  termination  without  cause.  The
agreements with Messrs. Bergeron and Goldstein prohibit each from competing with
the Company for one year after  termination  unless he elects to waive the right
to amounts otherwise payable. A separate business protection  agreement with Mr.
Block  prohibits  him  from  competing  with  the  Company  for one  year  after
termination.  The agreement with Dr. George makes any  post-termination  payment
contingent on his refraining from competing with the Company.  The agreements do
not expire by their terms and are  terminable by the Company with cause (upon 90
days' notice, in the case of Mr. Goldstein) or, subject to payment of the salary
amounts described above, without cause.

COMPENSATION OF  DIRECTORS

Under the Company's 1991 Stock Award Plan,  nonemployee directors of the Company
are  eligible to receive  nonqualified  stock  options.  Such  options have been
granted to nonemployee  directors on the basis  described  below.  The Board may
decide to grant options on other terms and in other amounts at any time.

Initial Options. Each person who becomes a nonemployee director has been granted
a stock option to purchase 50,000 shares of Common Stock (an "Initial  Option").
A  newly-elected  Chairman of the Board has been  entitled to receive an Initial
Option to purchase an additional  25,000 shares (75,000 shares if not previously
a nonemployee director).  Initial Options are granted at an exercise price equal
to the fair market value of a share on the date of grant minus the lesser of (a)
$2.00 or (b) 25 percent of such fair market value.  Each Initial  Option becomes
exercisable in annual  installments  based upon continued  service as a director
and expires at the end of five years following the director's  retirement or one
year  following the  director's  death,  disability or cessation of service as a
director for any other reason.  An Initial  Option will  generally  become fully
exercisable  by the date of the fourth annual  meeting of  shareholders  through
which the director has served on the Board.  Initial Options become  exercisable
in full immediately upon the occurrence of a change in control of the Company. A
change in control of the Company  would occur on the happening of such events as
the  beneficial  ownership  by a person  or group of 30  percent  or more of the
outstanding  Common  Stock,  certain  changes in Board  membership  affecting  a
majority  of  positions,  certain  mergers  or  consolidations,  a sale or other
transfer of all or substantially all the Company's assets, or approval by the

EPITOPE, INC.
10
<PAGE>

shareholders of a plan of liquidation or dissolution of the Company,  as well as
any change in control  required to be reported by the proxy  disclosure rules of
the Commission.

Payment of the exercise  price may be made in cash or by delivery of  previously
acquired  shares  of  Common  Stock  having  a fair  market  value  equal to the
aggregate  exercise  price.  To the extent  that  payment is made in  previously
acquired shares, the director is automatically granted a replacement  ("reload")
option for a number of shares equal to the number  delivered  upon exercise with
an exercise  price equal to the fair market  value of a share of Common Stock on
the date of exercise. Reload options become exercisable in full six months after
the grant date.

RENEWAL OPTIONS. Additional nonqualified stock options have been granted to each
nonemployee  director  to  purchase  15,000  shares  of Common  Stock  ("Renewal
Options")  as of or prior to the  annual  meeting of  shareholders  at which the
options  most  recently  granted to such  nonemployee  director  fully vest (the
"Renewal Year Meeting").  Renewal Options vest in three equal  installments,  on
the dates of the three annual  meetings of  shareholders  following  the Renewal
Year Meeting, subject to acceleration of vesting upon the occurrence of a change
in control of the Company.  The other terms of Renewal Options are comparable to
those of Initial Options,  except that Renewal Options do not provide for reload
options.

                 REPORT OF THE EXECUTIVE COMPENSATION COMMITTEE

The following report of the Executive  Compensation  Committee of the Board (the
"Committee")  shall not be  deemed  to be  incorporated  by  reference  into any
previous  filing  by the  Company  under  either  the  Securities  Act  of  1933
("Securities Act") or the Securities  Exchange Act of 1934 ("Exchange Act") that
incorporates  future  Securities Act or Exchange Act filings in whole or in part
by reference.

GENERAL. The Committee, which is composed of independent, nonemployee directors,
is responsible for establishing and  administering  the Company's  policies that
govern executive compensation and benefit practices. The Committee evaluates the
performance of the executive  officers and determines  their salary,  merit cash
bonus and related  benefits.  The Committee also grants certain awards under the
Company's stock award plans.

COMPENSATION  PHILOSOPHY.  The  Company's  executive  compensation  programs are
designed to (i) align the interests of executive  management  with the long-term
interests of the shareholders,  (ii) motivate Company  executives to achieve the
strategic   business  goals  of  the  Company  and  recognize  their  individual
contributions,   and  (iii)  provide   compensation   opportunities   which  are
competitive  with those offered by other medical products  companies  similar in
size  and  performance  to the  Company.  In  furtherance  of these  goals,  the
components of executive  compensation  include base salary,  merit cash bonuses,
stock option grants and other benefits and are linked to individual performance.

BASE SALARY. At least annually,  the Committee sets the salary for all executive
officers.  The  Committee  receives  and  considers  management  recommendations
concerning salary  adjustments for executive  officers,  as well as compensation
data regarding other medical products companies.  The Company generally tries to
maintain  executive  salaries  near the median level paid by similarly  situated
companies.  The Committee  approved  increases in executive salaries (other than
the Chief  Executive  Officer)  during fiscal year 1999 based on its belief that
the Company had  demonstrated  improvement  in  controlling  costs and had taken
significant  steps toward the  execution of its  business  plan in 1998,  and to
maintain  salaries  at  competitive  levels.  The  salary of Dr.  George,  Chief
Scientific Officer of the Company, was increased substantially for 1999 to bring
his  compensation in line with other officers at the Company with similar levels
of responsibility.

The Committee  originally  established the salary level and overall compensation
package  for its  Chief  Executive  Officer  based on its  determination  of the
competitive  requirements to attract a suitable candidate. It conducted a survey
of executive  salaries at similarly  situated companies as part of that process.
The Chief Executive  Officer's salary was not raised in 1999, but Mr. Morgan was
awarded 75,000 options in lieu of a salary increase.  The Committee felt that an
option grant was the most effective means of providing competitive  compensation
to the Chief Executive Officer while keeping the interests of management in line
with the long-term interests of shareholders of the Company.

MERIT CASH BONUSES.  No merit cash bonuses were awarded during fiscal year 1999.

                                                                   EPITOPE, INC.
                                                                              11
<PAGE>

STOCK  GRANTS.   As  previously  noted,  an  important  goal  of  the  Company's
compensation  program is to align the  interests of the  executive  officers and
other employees with the long-term interests of the Company's  shareholders.  In
furtherance  of this goal,  the Board of Directors  adopted the 1991 Stock Award
Plan (the "1991  Plan")  pursuant  to which the  Company  may grant  stock-based
awards to directors,  officers,  and employees of, and  consultants and advisers
to,  the  Company.  The Board has  adopted  and is  submitting  for  shareholder
approval at the 2000 annual  meeting the  Epitope,  Inc.  2000 Stock Award Plan,
which will replace the 1991 Plan.

In general,  the size of individual option grants is determined by the Committee
based on the  executive's  duties and the levels of option grants for executives
with comparable  positions at other medical  products  companies.  The Committee
does not  consider the amount and terms of options  already  held by  individual
executive officers in making new grants.  During fiscal year 1999, stock options
and  restricted  stock were  granted to William D.  Block,  who was hired as the
Company's  Vice  President  of Sales and  Marketing.  The number of options  and
shares of restricted  stock were  negotiated as part of Mr.  Block's  employment
offer, within limits set by the Committee. Stock options were awarded to John W.
Morgan in lieu of a pay raise, as described above. Stock options were awarded to
Charles E.  Bergeron,  J. Richard  George and Andrew S. Goldstein as part of the
Company's practice of issuing additional options each year.

OTHER COMPENSATION  VEHICLES.  The Company also has a 401(k) Profit Sharing Plan
(the "401(k) Plan"), which allows participants to defer compensation pursuant to
Section  401(k) of the  Internal  Revenue  Code.  All  employees of the Company,
including  executives,  are eligible to  participate in the 401(k) Plan provided
certain  qualifications  are met. In addition to amounts which  participants may
elect to contribute to the 401(k) Plan, the Company makes matching contributions
to the 401(k) Plan in Common  Stock of the Company,  which are  allocated to all
participants.  Payments of benefits accrued for 401(k) Plan participants will be
made upon  retirement  or upon  termination  of  employment  prior to retirement
provided certain conditions have been met by the employee prior to termination.

EXECUTIVE COMPENSATION COMMITTEE:

W. Charles Armstrong, Chairman
G. Patrick Sheaffer
Robert J. Zollars

           COMPENSATION COMMITTEE INTERLOCKS AND INSIDER PARTICIPATION

W.  Charles  Armstrong,  G. Patrick  Sheaffer  and Robert J.  Zollars  served as
members of the Executive  Compensation  Committee  during fiscal year 1999.  Mr.
Armstrong served as Interim President and Chief Executive Officer of the Company
from June 1997 until October 1997 while the Company conducted a search for a new
Chief Executive  Officer.  Mr. Armstrong left the Committee during the period he
served as an officer of the Company. He is not currently serving as an officer.

EPITOPE, INC.
12
<PAGE>

                          STOCK PRICE PERFORMANCE GRAPH

The following  graph compares the  cumulative  total returns to investors in the
Company's  Common Stock,  the Standard & Poors 500 Stock Index,  and the Russell
2000 Index for the period from October 1, 1994,  through September 30, 1999. The
graph  assumes that $100 was invested on September  30, 1994,  in the  Company's
Common Stock and in each of the  above-mentioned  indices and that all dividends
were  reinvested.  The Russell 2000 Index is an index of  companies  with market
capitalizations similar to the Company. It has been selected because the Company
has been unable to identify a peer group of companies for comparison.  No single
public or private company has a comparable mix of technologies under development
or  products  which  serve  the  same  markets  as the  Company.  The  Company's
management   believes   that  an  index  of  companies   with   similar   market
capitalizations  provides a reasonable  basis for  comparing  total  shareholder
returns.  Shareholders  are  cautioned  that the  graph  shows  the  returns  to
investors  only as of the  dates  noted  and may  not be  representative  of the
returns for any other past or future period.


                 COMPARISON OF FIVE YEAR CUMULATIVE TOTAL RETURN
       AMONG EPITOPE, INC., THE S & P 500 INDEX AND THE RUSSELL 2000 INDEX



            [GRAPHIC OMITTED IN WHICH THE FOLLOWING DATA IS DEPICTED:]

     DATE            9/94      9/95       9/96       9/97       9/98      9/99
     ----           ------    ------     ------     ------     ------    ------
     EPITOPE        $ 100    $   70      $  70      $  42      $  20     $  35
     S & P 500        100       130        156        219        239       306
     RUSSELL 2000     100       123        140        186        154       177



Note:  The stock  performance  data for the Company  used to generate  the graph
above does not include any adjustment  for the spin-off of the Company's  former
subsidiary,  Agritope,  Inc.,  which was effected as a special stock dividend to
the Company's  shareholders.  In the spin-off, each shareholder of record of the
Company on December 26, 1997, received one share of Agritope, Inc., common stock
for each five shares of the Company's Common Stock.

                                                                   EPITOPE, INC.
                                                                              13
<PAGE>


ITEM 2                  APPROVAL OF 2000 STOCK AWARD PLAN

GENERAL

On November 16, 1999, the Board adopted,  subject to shareholder  approval,  the
Epitope,  Inc. 2000 Stock Award Plan (the "Plan").  The Plan covers a maximum of
2,500,000  shares of Common Stock,  plus the number of shares that are available
for grant under the  Epitope,  Inc.  1991 Stock Award Plan (the "1991  Plan") on
February 15, 2000, or become  available under the terms of the Plan  thereafter.
This  number of shares  was  selected  based on the  Board's  estimation  of the
Company's needs under the Plan for the foreseeable future. The shares subject to
grant have a market value equal to $5.25 per share based on the closing price of
the Common Stock on December 15, 1999.

The Plan is intended to replace the 1991 Plan. Incentive stock options cannot be
granted under the 1991 Plan after January 8, 2001.  The 1991 Plan was originally
approved by the Company's shareholders at the 1991 annual meeting.  Increases in
the number of shares available for issuance under the 1991 Plan were approved by
the shareholders at the annual meetings in 1993, 1994, 1995, and 1997.

Assuming that a quorum is present at the meeting, the Plan will be approved upon
the affirmative  vote of the holders of a majority of the shares of Common Stock
present in person or by proxy. Shares represented by a Proxy which are not voted
for  approval of the Plan (by voting no or  abstaining)  will have the effect of
voting  against  the Plan.  Your Board  recommends  that  shareholders  vote FOR
approval of the Plan.

A summary description of certain terms and provisions of the Plan follows.  This
summary is subject to the detailed  terms and  provisions of the Plan, a copy of
which is included as an exhibit to this Proxy Statement.

PURPOSE

The purpose of the Plan is to promote and advance the  interests  of the Company
and its  shareholders  by enabling  the Company to attract,  retain,  and reward
employees,  outside advisors, and directors of the Company and any subsidiaries.
The Plan is intended to strengthen the mutuality of interests between employees,
advisors,  and directors and the Company's shareholders by offering equity-based
incentives to promote the long-term growth,  profitability and financial success
of the Company.

AWARDS AND ELIGIBILITY

The Plan provides for stock-based awards to (i) employees of the Company and any
subsidiaries,  (ii) members of advisory  committees or other  consultants to the
Company or its subsidiaries ("Advisors"), and (iii) nonemployee directors of the
Company.  Persons who help the Company raise money by selling  securities or who
maintain a market for the Company's  securities  are not eligible to participate
in the Plan as Advisors. In addition,  only Advisors who, in the judgment of the
Committee  (as defined  below),  are or will be  contributors  to the  long-term
success of the Company  will be eligible to receive  Awards.  As of December 15,
1999, the Company had 82 employees,  four persons serving as Advisors, and seven
nonemployee  directors,  all of whom are  eligible to receive  Awards  under the
Plan.  Awards that may be granted  under the Plan include stock  options,  stock
appreciation   rights,   restricted  awards,   performance   awards,  and  other
stock-based awards (collectively, "Awards").

The Executive Compensation Committee of the Board (the "Committee")  administers
the Plan and  determines  the persons  who are to receive  Awards and the types,
amounts,  and terms of Awards.  For example,  the  Committee  may  determine the
exercise price,  the form of payment of the exercise price, the number of shares
subject  to an  Award,  and  the  date  or  dates  on  which  an  Award  becomes
exercisable.  The  Committee may delegate to one or more officers of the Company
the authority to determine the recipients of and the types, amounts and terms of
Awards granted to participants who are not Reporting Persons.

No Awards  have been or will be granted  under the Plan prior to the date of the
Annual  Meeting.  If approved at the Annual  Meeting,  the Plan will continue in
effect until Awards have been granted  covering all  available  shares under the
Plan or the Plan is otherwise  terminated by the Board.  Termination of the Plan
will not affect outstanding Awards.

EPITOPE, INC.
14
<PAGE>

The Plan permits the Board to amend the Plan, subject to shareholder approval if
required by law or rules of a stock exchange or over-the-counter trading system.
In order to  retain  favorable  treatment  of Awards  under tax laws,  the Board
cannot  increase  the  number  of shares  covered  by the Plan  without  further
shareholder approval.

The  following  is a brief  summary of the  various  types of Awards that may be
granted under the Plan.

OPTIONS. Options granted under the Plan may be either incentive stock options, a
tax-favored  form of  Award  meeting  the  requirements  of  Section  422 of the
Internal Revenue Code ("ISOs"), or nonqualified options,  which are not entitled
to special tax treatment.  ISOs must expire no more than ten years from the date
of grant. The Plan does not limit the maximum term of nonqualified  options. The
exercise  price of any ISO granted  under the Plan may not be less than the fair
market value of the Common Stock on the date of grant. The exercise price of any
nonqualified option generally may not be less than 75 percent of the fair market
value of the  Common  Stock  on the  date of  grant.  The  Plan  authorizes  the
Committee  to  issue  deferred   compensation   options  with  an  option  price
substantially  less than the fair market  value (but not less than $1 per share)
for the purpose of deferring a specified amount of income for a recipient.

The Committee,  in its  discretion,  may provide in the agreement  evidencing an
option  that,  to the  extent  that the  option is  exercised  using  previously
acquired  shares of Common  Stock,  the option  holder  shall  automatically  be
granted a replacement  ("reload")  option for a number of shares of Common Stock
equal to the number of shares  surrendered  upon  exercise  with an option price
equal to the fair  market  value of  Common  Stock on the date of  exercise  and
subject to such other terms as the Committee determines.

In no event may options for more than 500,000  shares of Common Stock be granted
to any individual under the Plan during any fiscal year period.

STOCK  APPRECIATION  RIGHTS. A recipient of stock  appreciation  rights ("SARs")
will receive,  upon  exercise,  a payment (in cash or in shares of Common Stock)
based on the increase in the price of a share of Common  Stock  between the date
of grant  and the date of  exercise.  SARs may be  granted  in  connection  with
options or other Awards  granted under the Plan or may be granted as independent
Awards.

RESTRICTED  AWARDS.  Restricted Awards may take the form of restricted shares or
restricted  units.  Restricted  shares  are  shares of Common  Stock that may be
subject to forfeiture if the  recipient  terminates  employment or service as an
Advisor during a specified period (the "Restriction Period"). Stock certificates
representing restricted shares are issued in the name of the recipient,  but are
held by the Company until the  expiration of the  Restriction  Period.  From the
date of issuance of restricted  shares,  the recipient is entitled to the rights
of a  shareholder  with  respect to the shares,  including  voting and  dividend
rights.  Restricted  units are Awards of units equivalent in value to a share of
Common  Stock,  which  similarly  may be subject to  forfeiture if the recipient
terminates  employment or service as an Advisor during a Restriction  Period. At
the  expiration of the  Restriction  Period,  payment with respect to restricted
units is made in an amount  equal to the value of the number of shares of Common
Stock  covered by the  restricted  units.  Payment may be in cash,  unrestricted
shares of Common Stock, or any other form approved by the Committee.

PERFORMANCE  AWARDS.  Performance  Awards are designated in units  equivalent in
value to a share of Common Stock.  A Performance  Award is subject to forfeiture
if or to the extent that the Company,  a subsidiary,  an operating group, or the
recipient, as specified by the Committee in the Award, fails to meet performance
goals established for a designated performance cycle.  Performance Awards earned
by attaining  performance  goals are paid at the end of a  performance  cycle in
cash,  shares of Common Stock, or any other form approved by the Committee.  The
number of shares of Common Stock  issuable  with respect to  Performance  Awards
granted to any  individual  executive  officer may not exceed 150,000 shares for
any calendar year.

OTHER  STOCK-BASED  AWARDS.  The  Committee  may grant other Awards that involve
payments or grants of shares of Common  Stock or are  measured by or in relation
to shares of Common Stock.

FEDERAL INCOME TAX CONSEQUENCES

The following discussion summarizes the principal anticipated federal income tax
consequences  of  Awards  granted  under  the  Plan to  participants  and to the
Company.

                                                                   EPITOPE, INC.
                                                                              15
<PAGE>

INCENTIVE  STOCK  OPTIONS.  A recipient  of an option  does not realize  taxable
income upon the grant or exercise of an ISO. If no  disposition of shares occurs
within  two  years  from the date of grant or  within  one year from the date of
exercise, then (a) upon the sale of the shares, any amount realized in excess of
the exercise  price is taxed to the option  recipient as long-term  capital gain
and any loss sustained will be a long-term capital loss, and (b) no deduction is
allowed  to the  Company  for  federal  income tax  purposes.  For  purposes  of
computing   alternative   minimum  taxable  income,  an  ISO  is  treated  as  a
non-qualified option.

If shares of Common Stock  acquired  upon the exercise of an ISO are disposed of
prior to the expiration of the two-year and one-year  holding periods  described
above,  then (a) the  recipient  will  realize  ordinary  income  in the year of
disposition  in an amount  equal to the excess (if any) of the fair market value
of the shares at  exercise  (or, if less,  the amount  realized on a sale of the
shares) over the exercise price thereof and (b) the Company would be entitled to
deduct such  amount.  Any further  gain  realized  is taxed as a  short-term  or
long-term capital gain, as applicable,  and does not result in any deduction for
the Company.  Any  disqualifying  disposition as described  above will generally
avoid the alternative minimum tax consequences of the exercise of an ISO.

NONQUALIFIED OPTIONS. No income is realized by an option recipient at the time a
nonqualified option is granted.  Upon exercise,  (a) ordinary income is realized
by the  option  recipient  in an  amount  equal to the  difference  between  the
exercise  price and the fair market  value of the shares on the date of exercise
and  (b)  the  Company  receives  a tax  deduction  for the  same  amount.  Upon
disposition  of the  shares,  appreciation  or  depreciation  after  the date of
exercise  is treated as a  short-term  or  long-term  capital  gain or loss,  as
applicable, and will not result in any deduction to the Company.

PAYMENT OF EXERCISE PRICE IN SHARES.  The Committee may permit  participants  to
pay all or a  portion  of the  exercise  price for an  option  using  previously
acquired  shares of Common Stock.  If an option is exercised and payment is made
in previously  held shares,  there is no taxable gain or loss to the participant
other  than any gain  recognized  as a result  of  exercise  of the  option,  as
described above.

STOCK  APPRECIATION  RIGHTS.  The grant of a SAR to a participant will not cause
the  recognition  of income by the  participant.  Upon  exercise  of a SAR,  the
participant  will realize ordinary income equal to the amount of cash payable to
the  participant  plus the fair  market  value of any  shares  of  Common  Stock
delivered to the participant.  The Company will be entitled to a deduction equal
to the amount of ordinary  income realized by the participant in connection with
the exercise of a SAR.

RESTRICTED  AWARDS AND PERFORMANCE  AWARDS.  Generally,  a participant  will not
recognize any income upon issuance of a Restricted  Award or  Performance  Award
that is subject to forfeiture.  Generally, a participant will recognize ordinary
income upon the vesting of Restricted Awards or Performance  Awards in an amount
equal to the amount of cash  payable  to the  participant  plus the fair  market
value of shares of Common Stock  delivered to the  participant.  Dividends  paid
with respect to Awards  during the period such Awards are subject to  forfeiture
will be taxable as ordinary income to the  participant.  However,  a participant
may elect to recognize  compensation income upon the grant of restricted shares,
based on the fair  market  value of the  shares of Common  Stock  subject to the
Award at the date of grant. If a participant  makes such an election,  dividends
paid with  respect to the  restricted  shares  will not be  treated as  ordinary
income,  but rather as dividend  income,  and the participant will not recognize
additional  income when the restricted shares vest. The Company will be entitled
to a  deduction  equal  to the  amount  of  ordinary  income  recognized  by the
participant.  If a participant who receives an Award of restricted  shares makes
the special election described above, the Company will not be entitled to deduct
dividends paid with respect to the restricted shares.

LIMITATION  ON  DEDUCTIBILITY  OF CERTAIN  COMPENSATION.  Section  162(m) of the
Internal  Revenue Code  generally  makes  nondeductible  to the Company  taxable
compensation paid to a single individual in excess of $1 million in any calendar
year if the  individual is the Chief  Executive  Officer or one of the next four
highest-paid executive officers, unless the excess compensation is considered to
be "performance  based." Among other  requirements  contained in Section 162(m),
the material  terms of a  compensation  plan in which such officers  participate
must be approved by shareholders  for awards or compensation  provided under the
plan  to be  considered  "performance  based."  The  Company  may in the  future
consider  structuring  Awards to  attempt  to meet the  requirements  of Section
162(m) if it determines the action to be advisable.

EPITOPE, INC.
16
<PAGE>


                                  ANNUAL REPORT

The Company's  Annual Report to Shareholders for the fiscal year ended September
30, 1999, accompanies this proxy statement. ON WRITTEN REQUEST, THE COMPANY WILL
PROVIDE, WITHOUT CHARGE, A COPY OF ITS ANNUAL REPORT ON FORM 10-K FOR THE FISCAL
YEAR ENDED  SEPTEMBER  30,  1999,  FILED WITH THE  COMMISSION  (INCLUDING A LIST
BRIEFLY  DESCRIBING  THE EXHIBITS  THERETO),  TO ANY RECORD HOLDER OR BENEFICIAL
OWNER OF THE  COMPANY'S  COMMON STOCK ON DECEMBER 15, 1999,  THE RECORD DATE FOR
THE ANNUAL  MEETING,  OR TO ANY PERSON WHO  SUBSEQUENTLY  BECOMES  SUCH A RECORD
HOLDER OR BENEFICIAL OWNER.  REQUESTS SHOULD BE DIRECTED TO THE ATTENTION OF THE
SECRETARY  OF THE  COMPANY AT THE ADDRESS OF THE COMPANY SET FORTH IN THE NOTICE
OF ANNUAL MEETING OF SHAREHOLDERS IMMEDIATELY PRECEDING THIS PROXY STATEMENT.

                             INDEPENDENT ACCOUNTANTS

PricewaterhouseCoopers   LLP,  independent  public  accountants,   examined  the
financial  statements of the Company for fiscal 1999.  No change in  independent
public  accountants  is  contemplated  for  fiscal  2000.  The  Company  expects
representatives  of  PricewaterhouseCoopers  LLP to be  present  at  the  Annual
Meeting  and  to  be  available  to  respond  to   appropriate   questions  from
shareholders.  The accountants  will have the opportunity to make a statement at
the meeting if they desire to do so.

                       DEADLINE FOR SHAREHOLDER PROPOSALS

Shareholders  of the Company may submit  proposals  for  inclusion  in the proxy
materials for the Company's  Annual  Meeting of  Shareholders  in 2001. Any such
proposals must meet the shareholder  eligibility and other requirements  imposed
by rules  issued by the  Commission  and must be received by the Company at 8505
S.W. Creekside Place, Beaverton,  Oregon 97008, Attention:  Secretary, not later
than September 13, 2000.

For any  proposal  that is not  submitted  for  inclusion  in next year's  proxy
materials,  but instead is sought to be presented directly, the persons named as
proxies  for the 2001 Annual  Meeting of  Shareholders  will have  discretionary
authority  to vote  proxies on any such  proposal if the  Company:  (1) receives
notice of the proposal  before the close of business on November  27, 2000,  and
advises  stockholders in the 2001 proxy materials about the nature of the matter
and how  management  intends  to vote on such  matter;  or (2) has not  received
notice of the proposal by the close of business on November 27, 2000. Notices of
intention to present proposals at the 2001 annual meeting should be forwarded to
the address listed above.


BY ORDER OF THE BOARD OF DIRECTORS
Andrew S. Goldstein


Secretary
January 11, 2000


                                                                   EPITOPE, INC.
                                                                              17
<PAGE>

                                                                         EXHIBIT
                                  EPITOPE, INC.

                              2000 STOCK AWARD PLAN

                                   ARTICLE 1
                            ESTABLISHMENT AND PURPOSE

         1.1  Establishment. Epitope, Inc. ("Corporation"),  hereby establishes
the Epitope,  Inc. 2000 Stock Award Plan (the "Plan"),  effective as of February
15, 2000, subject to shareholder approval as provided in Article 17.

         1.2  Purpose.  The  purpose of the Plan is to promote  and advance the
interests  of  Corporation  and its  shareholders  by  enabling  Corporation  to
attract,  retain,  and reward  employees,  outside  advisors,  and  directors of
Corporation  and  its  subsidiaries.  It is  also  intended  to  strengthen  the
mutuality of interests  between such  employees,  advisors,  and  directors  and
Corporation's shareholders. The Plan is designed to meet this intent by offering
stock  options and other  equity-based  incentive  awards,  thereby  providing a
proprietary  interest in  pursuing  the  long-term  growth,  profitability,  and
financial success of Corporation.

                                   ARTICLE 2
                                   DEFINITIONS

         2.1  Defined Terms. For purposes of the Plan, the following terms have
the meanings set forth below:

               "ADVISOR" means a natural person who is a consultant to or member
of an Advisory Committee of Corporation or a Subsidiary,  who provides bona fide
services  to  Corporation  and who is neither an employee  of  Corporation  or a
Subsidiary  nor a  Non-Employee  Director.  "Advisor"  excludes  any  person who
provides  services  to  Corporation  in  connection  with  the  offer or sale of
securities in a capital  raising  transaction or to promote or maintain a market
for  Corporation's  securities,  and any other person excluded from the class of
persons to whom securities may be offered  pursuant to a registration  statement
on Form S-8 or any successor form of registration statement.

               "ADVISORY  COMMITTEE"  means a scientific  advisory  committee to
Corporation or a Subsidiary.

               "AWARD" means an award or grant made to a Participant of Options,
Stock  Appreciation  Rights,  Restricted  Awards,  Performance  Awards, or Other
Stock-Based Awards pursuant to the Plan.

               "AWARD AGREEMENT" means an agreement as described in Section 6.4.

               "BOARD" means the Board of Directors of Corporation.

               "CODE" means the Internal Revenue Code of 1986, as amended and in
effect  from  time to time,  or any  successor  thereto,  together  with  rules,
regulations,  and interpretations  promulgated thereunder.  Where the context so
requires,  any reference to a particular Code section will be construed to refer
to the successor provision to such Code section.

               "COMMITTEE"  means  the  committee  appointed  by  the  Board  to
administer the Plan as provided in Article 3 of the Plan.

               "COMMON  STOCK"  means  the  Common  Stock,   no  par  value,  of
Corporation or any security of Corporation issued in substitution,  in exchange,
or in lieu of such stock.

               "CONTINUING   RESTRICTION"  means  a  Restriction   contained  in
Sections  6.7,  6.8, and 16.4 of the Plan and any other  Restrictions  expressly
designated by the Committee in an Award Agreement as a Continuing Restriction.

               "CORPORATION" means Epitope, Inc., an Oregon corporation,  or any
successor corporation.

EPITOPE, INC.
18
<PAGE>

               "DEFERRED   COMPENSATION  OPTION"  means  a  Nonqualified  Option
granted  with an option  price less than Fair Market  Value on the date of grant
pursuant to Section 7.9 of the Plan.

               "DISABILITY"  means the condition of being "disabled"  within the
meaning of Section 422(c)(6) of the Code. However,  the Committee may change the
foregoing  definition of  "Disability"  or may adopt a different  definition for
purposes of specific Awards.

               "EXCHANGE  ACT" means the  Securities  Exchange  Act of 1934,  as
amended and in effect from time to time,  or any  successor  statute.  Where the
context so requires,  any reference to a particular section of the Exchange Act,
or to any rule  promulgated  under the Exchange Act, shall be construed to refer
to successor provisions to such section or rule.

               "FAIR  MARKET  VALUE" means with  respect to Common  Stock,  on a
particular  day,  without regard to any  restrictions  (other than a restriction
which, by its terms,  will never lapse),  the mean between the reported high and
low sale  prices,  or, if there is no sale on such  day,  the mean  between  the
reported bid and asked prices,  of Shares of the Common Stock on that day or, if
that day is not a trading  day, the last prior  trading  day, on the  securities
exchange or  automated  securities  interdealer  quotation  system on which such
Shares have been traded.

               "INCENTIVE  STOCK  OPTION"  or "ISO"  means  any  Option  granted
pursuant to the Plan that is intended to be and is  specifically  designated  in
its Award Agreement as an "incentive stock option" within the meaning of Section
422 of the Code.

               "NON-EMPLOYEE DIRECTOR" means a member of the Board who is not an
employee of Corporation or any Subsidiary.

               "NONQUALIFIED  OPTION" or "NQO"  means any  Option,  including  a
Deferred  Compensation  Option,  granted  pursuant  to the  Plan  that is not an
Incentive Stock Option.

               "OPTION" means an ISO, an NQO, or a Deferred Compensation Option.

               "OTHER  STOCK-BASED  AWARD"  means an Award as defined in Section
11.1.

               "PARTICIPANT"  means an employee of  Corporation or a Subsidiary,
an Advisor, or a Non-Employee Director who is granted an Award under the Plan.

               "PERFORMANCE  AWARD"  means  an  Award  granted  pursuant  to the
provisions  of Article 10 of the Plan,  the  Vesting of which is  contingent  on
performance attainment.

               "PERFORMANCE   CYCLE"  means  a  designated   performance  period
pursuant to the provisions of Section 10.3 of the Plan.

               "PERFORMANCE  GOAL"  means  a  designated  performance  objective
pursuant to the provisions of Section 10.4 of the Plan.

               "PLAN" means this  Epitope,  Inc.  2000 Stock Award Plan,  as set
forth herein and as it may be amended from time to time.

               "REPORTING  PERSON"  means a  Participant  who is  subject to the
reporting requirements of Section 16(a) of the Exchange Act.

               "RESTRICTED  AWARD" means a Restricted Share or a Restricted Unit
granted pursuant to Article 9 of the Plan.

               "RESTRICTED  SHARE" means an Award described in Section 9.1(a) of
the Plan.

                                                                   EPITOPE, INC.
                                                                              19
<PAGE>

               "RESTRICTED  UNIT"  means an Award of units  representing  Shares
described in Section 9.1(b) of the Plan.

               "RESTRICTION"  means  a  provision  in the  Plan  or in an  Award
Agreement which limits the exercisability or  transferability,  or which governs
the  forfeiture,  of an Award or the Shares,  cash,  or other  property  payable
pursuant to an Award.

               "RETIREMENT" means:

                   (a) For  Participants  who  are  employees,  retirement  from
              active  employment  with  Corporation  and its  Subsidiaries at or
              after age 50, or such earlier  retirement  date as approved by the
              Committee for purposes of the Plan;

                   (b)  For  Participants   who  are   Non-Employee   Directors,
              termination of membership on the Board after  attaining age 50, or
              such  earlier  retirement  date as approved by the  Committee  for
              purposes of the Plan; and

                   (c) For Participants who are Advisors, termination of service
              as an Advisor after  attaining age 50, or such earlier  retirement
              date as approved by the Committee for purposes of the Plan.

However,  the Committee may change the foregoing  definition of  "Retirement" or
may adopt a different definition for purposes of specific Awards.

              "SHARE" means a share of Common Stock.

              "STOCK APPRECIATION RIGHT" or "SAR" means an Award to benefit from
the appreciation of Common Stock granted pursuant to the provisions of Article 8
of the Plan.

              "SUBSIDIARY"  means any  "subsidiary  corporation"  of Corporation
within the meaning of Section 424 of the Code,  namely any  corporation in which
Corporation  directly  or  indirectly  controls  50 percent or more of the total
combined voting power of all classes of stock having voting power.

              "VEST" or "VESTED" means:

                   (a) In the case of an Award that requires exercise,  to be or
              to  become  immediately  and  fully  exercisable  and  free of all
              Restrictions (other than Continuing Restrictions);

                   (b) In the case of an Award that is subject to forfeiture, to
              be or to become nonforfeitable,  freely transferable,  and free of
              all Restrictions (other than Continuing Restrictions);

                   (c) In the case of an Award that is  required to be earned by
              attaining  specified  Performance Goals, to be or to become earned
              and  nonforfeitable,   freely   transferable,   and  free  of  all
              Restrictions (other than Continuing Restrictions); or

                   (d) In the case of any other Award as to which payment is not
              dependent solely upon the exercise of a right, election, exercise,
              or option, to be or to become immediately  payable and free of all
              Restrictions (except Continuing Restrictions).

         2.2  Gender  and  Number.  Except  where  otherwise  indicated  by the
context,  any  masculine  or  feminine  terminology  used in the Plan shall also
include the opposite  gender;  and the  definition of any term in Section 2.1 in
the singular shall also include the plural, and vice versa.

EPITOPE, INC.
20
<PAGE>


                                   ARTICLE 3
                                 ADMINISTRATION

         3.1  General.  Except as  provided  in Section  3.7,  the Plan will be
administered by a Committee composed as described in Section 3.2.

         3.2  Composition of the Committee.  The Committee will be appointed by
the Board from among its  members  in a number and with such  qualifications  as
will meet the  requirements  for  approval by a committee  pursuant to both Rule
16b-3 under the Exchange  Act and Section  162m of the Code.  The Board may from
time to time remove members from, or add members to, the Committee. Vacancies on
the Committee,  however caused, will be filled by the Board. The initial members
of the  Committee  will  be the  members  of  Corporation's  existing  Executive
Compensation  Committee.  The  Board  may  at any  time  replace  the  Executive
Compensation  Committee with another Committee.  In the event that the Executive
Compensation  Committee  ceases to  satisfy  the  requirements  of Rule 16b-3 or
Section 162m of the Code, the Board will appoint  another  Committee  satisfying
such requirements.

         3.3  Authority of the  Committee.  The  Committee  will have full
power and authority  (subject to such orders or  resolutions as may be issued or
adopted  from  time to time by the  Board)  to  administer  the Plan in its sole
discretion, including the authority to:

                   (a)  Construe and interpret the Plan and any Award Agreement;

                   (b)  Promulgate,  amend,  and  rescind  rules and  procedures
         relating to the implementation of the Plan;

                   (c)  With respect to employees and Advisors:

                             (i)       Select the  employees  and  Advisors  who
                        shall be granted Awards;

                             (ii)      Determine  the number and types of Awards
                        to be granted to each such Participant;

                             (iii)     Determine the number of Shares,  or Share
                        equivalents, to be subject to each Award;

                             (iv)      Determine  the  option  price,   purchase
                        price, base price, or similar feature for any Award; and

                             (v)       Determine all the terms and conditions of
                        all Award  Agreements,  consistent with the requirements
                        of the Plan.

Decisions of the Committee,  or any delegate as permitted by the Plan,  shall be
final, conclusive, and binding on all Participants.

         3.4  Action  by  the  Committee.  A  majority  of  the  members  of the
Committee  will  constitute a quorum for the  transaction  of  business.  Action
approved by a majority  of the members  present at any meeting at which a quorum
is present,  or action in writing by all the members of the  Committee,  will be
the valid acts of the Committee.

         3.5  Delegation.  Notwithstanding  the  foregoing,  the  Committee  may
delegate to one or more officers of  Corporation  the authority to determine the
recipients,  types, amounts, and terms of Awards granted to Participants who are
not Reporting Persons.

         3.6  Liability of Committee Members. No member of the Committee will be
liable for any action or  determination  made in good faith with  respect to the
Plan, any Award, or any Participant.

                                                                   EPITOPE, INC.
                                                                              21
<PAGE>

         3.7  Awards to Non-Employee Directors. The Board or Committee may grant
Awards from time to time to Non-Employee Directors.

         3.8  Costs of Plan.  The costs and expenses of  administering  the Plan
will be borne by Corporation.


                                   ARTICLE 4
               DURATION OF THE PLAN AND SHARES SUBJECT TO THE PLAN

         4.1  Duration of the Plan.  The Plan is  effective  February  15, 2000,
subject to approval by Corporation's shareholders as provided in Article 17. The
Plan will remain in effect  until  Awards  have been  granted  covering  all the
available Shares or the Plan is otherwise  terminated by the Board.  Termination
of the Plan will not affect outstanding Awards.

         4.2  Shares Subject to the Plan.

              4.2.1     General.  The shares which may be made subject to Awards
under the Plan are Shares of Common Stock,  which may be either  authorized  and
unissued Shares or reacquired  Shares.  No fractional Shares may be issued under
the Plan.

              4.2.2     Number of Shares. The maximum number of Shares for which
Awards may be granted  under the Plan is  2,500,000  Shares,  plus the number of
Shares that are  available for grant under the Epitope,  Inc.,  1991 Stock Award
Plan (the "1991 Plan"), on February 15, 2000, subject to adjustment  pursuant to
Article 14 of the Plan.

              4.2.3     Availability  of Shares for Future  Awards.  If an Award
under the Plan, the 1991 Plan, or the Corporation's  Incentive Stock Option Plan
for Key Employees of Epitope,  Inc. (the "ISOP"), is canceled or expires for any
reason prior to having been fully Vested or  exercised  by a  Participant  or is
settled in cash in lieu of Shares or is exchanged for other  Awards,  all Shares
covered by such Awards will be made  available for future Awards under the Plan.
Furthermore,  any Shares  used as full or partial  payment to  Corporation  by a
Participant of the option, purchase, or other exercise price of an Award and any
Shares covered by a Stock  Appreciation Right which are not issued upon exercise
will become available for future Awards.

                                   ARTICLE 5
                                  ELIGIBILITY

         5.1  Employees   and   Advisors.   Officers  and  other   employees  of
Corporation and any Subsidiaries  (who may also be directors of Corporation or a
Subsidiary)  and  Advisors  who,  in the  Committee's  judgment,  are or will be
contributors to the long-term success of Corporation will be eligible to receive
Awards under the Plan.

         5.2  Non-Employee   Directors.   All  Non-Employee  Directors  will  be
eligible   to   receive   Awards   as   provided   in   Section   3.7   of   the
Plan.

                                   ARTICLE 6
                                     AWARDS

         6.1  Types of Awards. The types of Awards that may be granted under the
Plan are:

                   (a)  Options governed by Article 7 of the Plan;

                   (b)  Stock  Appreciation  Rights governed by Article 8 of the
         Plan;

                   (c)  Restricted Awards governed by Article 9 of the Plan;

                   (d)  Performance  Awards  governed by Article 10 of the Plan;
         and

                   (e)  Other Stock-Based  Awards or combination awards governed
         by Article 11 of the Plan.

EPITOPE, INC.
22
<PAGE>

In the discretion of the Committee,  any Award may be granted alone, in addition
to, or in tandem with other Awards under the Plan.

         6.2  General. Subject to the limitations of the Plan, the Committee may
cause Corporation to grant Awards to such  Participants,  at such times, of such
types,  in such amounts,  for such periods,  with such option  prices,  purchase
prices, or base prices, and subject to such terms, conditions,  limitations, and
restrictions as the Committee, in its discretion, deems appropriate.  Awards may
be granted  as  additional  compensation  to a  Participant  or in lieu of other
compensation to such Participant.  A Participant may receive more than one Award
and more than one type of Award under the Plan.

         6.3  Nonuniform  Determinations.  The Committee's  determinations under
the Plan or under one or more Award Agreements,  including  without  limitation,
(a) the selection of Participants to receive Awards, (b) the type, form, amount,
and  timing of  Awards,  (c) the terms of  specific  Award  Agreements,  and (d)
elections and  determinations  made by the Committee with respect to exercise or
payments  of  Awards,  need  not be  uniform  and may be  made by the  Committee
selectively  among  Participants  and Awards,  whether or not  Participants  are
similarly situated.

         6.4  Award Agreements.  Each Award will be evidenced by a written Award
Agreement between Corporation and the Participant. Award Agreements may, subject
to the provisions of the Plan, contain any provision approved by the Committee.

         6.5  Provisions Governing All Awards. All Awards will be subject to the
following provisions:

                   (a)  Alternative  Awards.  If any  Awards are  designated  in
         their Award  Agreements as alternative  to each other,  the exercise of
         all or part of one Award  automatically  will cause an immediate  equal
         (or pro rata) corresponding  termination of the other alternative Award
         or Awards.

                   (b)  Rights as  Shareholders.  No  Participant  will have any
         rights of a  shareholder  with  respect  to Shares  subject to an Award
         until such Shares are issued in the name of the Participant.

                   (c)  Employment Rights.  Neither the adoption of the Plan nor
         the  granting  of any  Award  will  confer on any  person  the right to
         continued employment with Corporation or any Subsidiary or the right to
         remain  as a  director  of  Corporation  or a  member  of any  Advisory
         Committee,  as the case may be, nor will it  interfere  in any way with
         the right of  Corporation  or a Subsidiary  to terminate  such person's
         employment  or to remove  such person as an Advisor or as a director at
         any time for any reason or for no reason, with or without cause.

                   (d)  Termination  Of  Employment.  The terms  and  conditions
         under which an Award may be exercised or will  continue to Vest,  if at
         all, after a  Participant's  termination of employment or service as an
         Advisor  or as a  Non-Employee  Director  will  be  determined  by  the
         Committee and specified in the applicable Award Agreement.

                   (e)  Change in Control. The Committee, in its discretion, may
         provide in any Award Agreement that in the event of a change in control
         of  Corporation  (as the  Committee  may define  such term in the Award
         Agreement), as of the date of such change in control:

                             (i)       All,  or a specified  portion of,  Awards
                   requiring   exercise   will  become  fully  and   immediately
                   exercisable,   notwithstanding   any  other   limitations  on
                   exercise;

                             (ii)      All,  or a specified  portion of,  Awards
                   subject to Restrictions will become fully Vested; and

                             (iii)     All,  or a specified  pOrtion of,  Awards
                   subject  to  Performance  Goals  will be  deemed to have been
                   fully earned.
                                                                   EPITOPE, INC.
                                                                              23
<PAGE>

         The  Committee,  in its  discretion,  may  include  change  in  control
         provisions  in some Award  Agreements  and not in others,  may  include
         different change in control  provisions in different Award  Agreements,
         and may include  change in control  provisions  for some Awards or some
         Participants and not for others.

                   (f)  Service  Periods.  At the time of granting  Awards,  the
         Committee may specify,  by resolution  or in the Award  Agreement,  the
         period or  periods  of  service  performed  or to be  performed  by the
         Participant in connection with the grant of the Award.

         6.6  Tax Withholding.

                   (a)  General.  Corporation will have the right to deduct from
         any settlement, including the delivery or Vesting of Shares, made under
         the Plan any federal, state, or local taxes of any kind required by law
         to be  withheld  with  respect to such  payments  or to take such other
         action as may be necessary in the opinion of Corporation to satisfy all
         obligations for the payment of such taxes. The recipient of any payment
         or distribution  under the Plan will make arrangements  satisfactory to
         Corporation  for  the   satisfaction   of  any  such   withholding  tax
         obligations.  Corporation will not be required to make any such payment
         or distribution under the Plan until such obligations are satisfied.

                   (b)  Stock   Withholding.   The   Committee,   in  its   sole
         discretion,  may permit a  Participant  to satisfy all or a part of the
         withholding  tax  obligations  incident to the  settlement  of an Award
         involving  payment or delivery of Shares to the  Participant  by having
         Corporation  withhold a portion of the Shares that would  otherwise  be
         issuable to the Participant.  Such Shares will be valued based on their
         Fair  Market  Value on the date the tax  withholding  is required to be
         made. Any stock  withholding with respect to a Reporting Person will be
         subject to such  limitations as the Committee may impose to comply with
         the requirements of the Exchange Act.

         6.7  Annulment  of Awards.  Any Award  Agreement  may provide  that the
grant  of an  Award  payable  in  cash  is  provisional  until  cash  is paid in
settlement  thereof or that grant of an Award  payable in Shares is  provisional
until the Participant becomes entitled to the certificate in settlement thereof.
In the event the  employment  (or  service as an Advisor  or  membership  on the
Board) of a Participant  is terminated for cause (as defined  below),  any Award
that is  provisional  will be  annulled as of the date of such  termination  for
cause. For the purpose of this Section 6.7, the term "for cause" has the meaning
set forth in the Participant's  employment agreement, if any, or otherwise means
any  discharge  (or removal) for material or flagrant  violation of the policies
and procedures of  Corporation or for other job  performance or conduct which is
materially  detrimental to the best interests of  Corporation,  as determined by
the Committee.

         6.8  Engaging in Competition With Corporation.  Any Award Agreement may
provide that, if a  Participant  terminates  employment  with  Corporation  or a
Subsidiary  for any  reason  whatsoever,  and  within 18  months  after the date
thereof  accepts  employment  with any  competitor of (or  otherwise  engages in
competition  with)  Corporation,  the  Committee,  in its sole  discretion,  may
require such  Participant  to return to  Corporation  the economic  value of any
Award that is realized or obtained  (measured at the date of exercise,  Vesting,
or payment) by such  Participant at any time during the period  beginning on the
date that is six months prior to the date of such  Participant's  termination of
employment with Corporation.

                                   ARTICLE 7
                                     OPTIONS

         7.1  Types of  Options.  Options  granted  under the Plan may be in the
form of Incentive  Stock Options or  Nonqualified  Options  (including  Deferred
Compensation  Options).  The  grant  of  each  Option  and the  Award  Agreement
governing each Option will identify the Option as an ISO or an NQO. In the event
the Code is amended to provide for tax-favored forms of stock options other than
or in addition to Incentive Stock Options, the Committee may grant Options under
the Plan meeting the requirements of such forms of options.

EPITOPE, INC.
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<PAGE>

         7.2  General.  Options will be subject to the terms and  conditions set
forth in Article 6 and this Article 7 and may contain such additional  terms and
conditions,  not  inconsistent  with the express  provisions of the Plan, as the
Committee (or the Board with respect to Awards to Non-Employee  Directors) deems
desirable.

         7.3  Option  Price.  Each Award  Agreement  for Options  will state the
option  exercise price per Share of Common Stock  purchasable  under the Option,
which will not be less than:

                   (a)  $1 per  share  in the  case of a  Deferred  Compensation
         Option;

                   (b)  75  percent of the Fair  Market  Value of a Share on the
         date of grant for all other Nonqualified Options; or

                   (c)  100 percent of the Fair  Market  Value of a Share on the
         date of grant for all Incentive Stock Options.

         7.4  Option Term. The Award  Agreement for each Option will specify the
term of each  Option,  which may be  unlimited  or may have a  specified  period
during which the Option may be exercised, as determined by the Committee.

         7.5  Time of  Exercise.  The  Award  Agreement  for  each  Option  will
specify, as determined by the Committee:

                   (a)  The  time  or  times   when  the  Option   will   become
         exercisable  and whether the Option will become  exercisable in full or
         in graduated amounts over a period specified in the Award Agreement;

                   (b)  Such other terms,  conditions,  and  restrictions  as to
         when the Option may be exercised as determined by the Committee; and

                   (c)  The  extent,  if any,  to which the Option  will  remain
         exercisable after the Participant ceases to be an employee, Advisor, or
         director of Corporation or a Subsidiary.

An Award  Agreement  for an Option  may,  in the  discretion  of the  Committee,
provide  whether,  and to what extent,  the Option will become  immediately  and
fully  exercisable (i) in the event of the death,  Disability,  or Retirement of
the  Participant,  or (ii)  upon  the  occurrence  of a  change  in  control  of
Corporation.

         7.6  Method of  Exercise.  The Award  Agreement  for each  Option  will
specify the method or methods of payment  acceptable upon exercise of an Option.
An Award  Agreement may provide that the option price is payable in full in cash
or, at the discretion of the Committee:

                   (a)  In  installments  on such terms and over such  period as
         the Committee determines;

                   (b)  In  previously  acquired  Shares  (including  Restricted
         Shares);

                   (c)  By  surrendering   outstanding  Awards  under  the  Plan
         denominated in Shares or in Share-equivalent units;

                   (d)  By delivery (in a form approved by the  Committee) of an
         irrevocable   direction  to  a  securities  broker  acceptable  to  the
         Committee:

                             (i)       To sell Shares  subject to the Option and
                   to deliver all or a part of the sales proceeds to Corporation
                   in  payment  of  all  or a  part  of  the  option  price  and
                   withholding taxes due; or

                                                                   EPITOPE, INC.
                                                                              25
<PAGE>

                             (ii)      To pledge Shares subject to the Option to
                   the broker as  security  for a loan and to  deliver  all or a
                   part of the loan proceeds to Corporation in payment of all or
                   a part of the option price and withholding taxes due; or

                   (e)  In any  combination  of the  foregoing  or in any other
         form approved by the Committee.

If Restricted  Shares are  surrendered  in full or partial  payment of an Option
price, a  corresponding  number of the Shares issued upon exercise of the Option
will be Restricted  Shares subject to the same  Restrictions  as the surrendered
Restricted Shares.

         7.7  Special  Rules  for  Incentive  Stock  Options.  In the case of an
Option designated as an Incentive Stock Option,  the terms of the Option and the
Award  Agreement  must be in  conformance  with  the  statutory  and  regulatory
requirements specified in Section 422 of the Code, as in effect on the date such
ISO is  granted.  ISOs may be granted  only to  employees  of  Corporation  or a
Subsidiary.  ISOs may not be granted  under the Plan after  February  15,  2010,
unless the ten-year  limitation  of Section  422(b)(2) of the Code is removed or
extended.

         7.8  Restricted Shares. In the discretion of the Committee,  the Shares
issuable upon  exercise of an Option may be Restricted  Shares if so provided in
the Award Agreement.

         7.9  Deferred   Compensation   Options.   The  Committee  may,  in  its
discretion,  grant Deferred  Compensation Options with an option price less than
Fair  Market  Value to provide a means for  deferral of  compensation  to future
dates.  The option price will be determined by the Committee  subject to Section
7.3(a) of the Plan.  The number of Shares  subject  to a  Deferred  Compensation
Option will be determined by the Committee,  in its discretion,  by dividing the
amount of compensation to be deferred by the difference  between the Fair Market
Value  of a Share  on the date of grant  and the  option  price of the  Deferred
Compensation Option. Amounts of compensation deferred with Deferred Compensation
Options may include  amounts earned under Awards granted under the Plan or under
any other compensation program or arrangement of Corporation as permitted by the
Committee.  The Committee  may grant  Deferred  Compensation  Options only if it
reasonably  determines  that the recipient of such an Option is not likely to be
deemed to be in constructive receipt for income tax purposes of the income being
deferred.

         7.10 Reload Options. The Committee,  in its discretion,  may provide in
an Award  Agreement  for an Option  that in the  event  all or a portion  of the
Option is exercised by the Participant  using previously  acquired  Shares,  the
Participant will  automatically be granted a replacement  Option (with an option
price  equal to the Fair Market  Value of a Share on the date of such  exercise)
for a number of Shares  equal to (or equal to a portion of) the number of shares
surrendered  upon  exercise of the Option.  Such reload  Option  features may be
subject to such terms and conditions as the Committee shall determine, including
without  limitation,  a condition that the Participant  retain the Shares issued
upon exercise of the Option for a specified period of time.

         7.11 Limitation on Number of Shares Subject to Options. In no event may
Options for more than 500,000 Shares be granted to any individual under the Plan
during any fiscal year period.

                                   ARTICLE 8
                            STOCK APPRECIATION RIGHTS

         8.1  General.  Stock  Appreciation  Rights will be subject to the terms
and  conditions  set forth in Article 6 and this  Article 8 and may contain such
additional terms and conditions,  not inconsistent with the express terms of the
Plan,  as the  Committee  (or the Board with  respect to Awards to  Non-Employee
Directors) deems desirable.

         8.2  Nature of Stock Appreciation  Right. A Stock Appreciation Right is
an Award entitling a Participant to receive an amount equal to the excess (or if
the Committee  determines at the time of grant,  a portion of the excess) of the
Fair Market  Value of a Share of Common Stock on the date of exercise of the SAR
over  the  base  price,  as  described  below,  on the date of grant of the SAR,
multiplied  by the  number  of  Shares  with  respect  to which the SAR has been
exercised.  The base  price will be  designated  by the  Committee  in the Award
Agreement  for the SAR and may be the Fair Market  Value of a Share on the grant
date of the SAR or such other higher or lower price as the Committee determines.


EPITOPE, INC.
26
<PAGE>

         8.3  Exercise.  A  Stock  Appreciation  Right  may  be  exercised  by a
Participant in accordance  with  procedures  established  by the Committee.  The
Committee may also provide that an SAR will be automatically exercised on one or
more  specified  dates  or  upon  the  satisfaction  of  one or  more  specified
conditions.  In the case of SARs granted to Reporting  Persons,  exercise of the
SAR will be limited by the  Committee to the extent  required to comply with the
applicable requirements of Rule 16b-3 under the Exchange Act.

         8.4  Form of Payment.  Payment  upon  exercise of a Stock  Appreciation
Right may be made in cash, in installments, in Shares, by issuance of a Deferred
Compensation  Option,  or in any  combination of the foregoing,  or in any other
form as the Committee determines.

         8.5  Limitation  on Number of Shares  Subject to SARs.  In no event may
SARs for more than 500,000  Shares be granted to any  individual  under the Plan
during any fiscal year period.

                                   ARTICLE 9
                                RESTRICTED AWARDS

         9.1  Types of Restricted  Awards.  Restricted  Awards granted under the
Plan may be in the form of either Restricted Shares or Restricted Units.

                   (a)  Restricted  Shares.  A  Restricted  Share is an Award of
         Shares  transferred  to  a  Participant   subject  to  such  terms  and
         conditions  as the  Committee  deems  appropriate,  including,  without
         limitation,  restrictions on the sale,  assignment,  transfer, or other
         disposition  of such  Restricted  Shares and may include a  requirement
         that the Participant forfeit such Restricted Shares back to Corporation
         upon termination of Participant's  employment (or service as an Advisor
         or  Non-Employee  Director)  for specified  reasons  within a specified
         period  of time or upon  other  conditions,  as set  forth in the Award
         Agreement for such  Restricted  Shares.  Each  Participant  receiving a
         Restricted Share will be issued a stock  certificate in respect of such
         Shares,  registered  in the  name  of  such  Participant,  and  will be
         required to execute a stock  power in blank with  respect to the Shares
         evidenced  by  such  certificate.   The  certificate   evidencing  such
         Restricted  Shares  and the  stock  power  will be held in  custody  by
         Corporation until the Restrictions thereon will have lapsed.

                   (b)  Restricted Units. A Restricted Unit is an Award of units
         (with each unit having a value  equivalent  to one Share)  granted to a
         Participant subject to such terms and conditions as the Committee deems
         appropriate, and may include a requirement that the Participant forfeit
         such Restricted Units upon termination of Participant's  employment (or
         service as an Advisor or Non-Employee  Director) for specified  reasons
         within a  specified  period of time or upon  other  conditions,  as set
         forth in the Award Agreement for such Restricted Units.

         9.2   General. Restricted  Awards  will be  subject  to the  terms  and
conditions of Article 6 and this Article 9 and may contain such additional terms
and conditions, not inconsistent with the express provisions of the Plan, as the
Committee (or the Board with respect to Awards to Non-Employee  Directors) deems
desirable.

         9.3  Restriction  Period.  Restricted  Awards  will  provide  that such
Awards, and the Shares subject to such Awards,  may not be transferred,  and may
provide that, in order for a Participant to Vest in such Awards, the Participant
must remain in the employment (or remain as an Advisor or Non-Employee Director)
of Corporation or its  Subsidiaries,  subject to relief for reasons specified in
the Award Agreement, for a period commencing on the date of the Award and ending
on such later date or dates as the Committee designates at the time of the Award
(the "Restriction Period"). During the Restriction Period, a Participant may not
sell,  assign,  transfer,  pledge,  encumber,  or  otherwise  dispose  of Shares
received under or governed by a Restricted  Award grant.  The Committee,  in its
sole  discretion,  may provide  for the lapse of  restrictions  in  installments
during the Restriction  Period.  Upon  expiration of the applicable  Restriction
Period  (or  lapse of  Restrictions  during  the  Restriction  Period  where the
Restrictions  lapse  in  installments)  the  Participant  shall be  entitled  to
settlement  of the  Restricted  Award or  portion  thereof,  as the case may be.
Although  Restricted Awards will usually Vest based on continued  employment (or
service as an Advisor or  Non-Employee  Director) and  Performance  Awards under
Article 10 shall  usually Vest based on  attainment of  Performance  Goals,  the
Committee,  in its  discretion,  may condition  Vesting of Restricted  Awards on
attainment of Performance

                                                                   EPITOPE, INC.
                                                                              27
<PAGE>

Goals as well as continued  employment (or service as an Advisor or Non-Employee
Director). In such case, the Restriction Period for such a Restricted Award will
include the period prior to satisfaction of the Performance Goals.

         9.4  Forfeiture. If a Participant ceases to be an employee,  Advisor of
Corporation  or a Subsidiary or  Non-Employee  Director  during the  Restriction
Period for any reason  other than  reasons  which may be  specified  in an Award
Agreement (such as death,  Disability,  or Retirement),  the Award Agreement may
require  that  all  non-Vested  Restricted  Awards  previously  granted  to  the
Participant be forfeited and returned to Corporation.

         9.5  Settlement of Restricted Awards.

                   (a)  Restricted  Shares.  Upon Vesting of a Restricted  Share
         Award, the legend on such Shares will be removed and the  Participant's
         stock  power  will  be  returned  and the  Shares  will  no  longer  be
         Restricted Shares. The Committee may also, in its discretion,  permit a
         Participant  to  receive,   in  lieu  of  unrestricted  Shares  at  the
         conclusion of the Restriction Period, payment in cash, installments,  a
         Deferred  Compensation  Option  equal to the Fair  Market  Value of the
         Restricted  Shares  as of the date the  Restrictions  lapse,  or in any
         other manner or combination  of such methods as the  Committee,  in its
         sole discretion, determines.

                   (b)  Restricted  Units.  Upon  Vesting of a  Restricted  Unit
         Award, a Participant will be entitled to receive payment for Restricted
         Units in an amount  equal to the  aggregate  Fair  Market  Value of the
         Shares  covered  by such  Restricted  Units  at the  expiration  of the
         Applicable  Restriction  Period.  Payment in settlement of a Restricted
         Unit will be made as soon as  practicable  following the  conclusion of
         the applicable  Restriction Period in cash, in installments,  in Shares
         equal to the number of  Restricted  Units,  by  issuance  of a Deferred
         Compensation  Option,  or in any other  manner or  combination  of such
         methods as the Committee, in its sole discretion, determines.

         9.6  Rights as a Shareholder.  A Participant will have, with respect to
unforfeited  Shares received under a grant of Restricted  Shares, all the rights
of a shareholder of Corporation, including the right to vote the Shares, and the
right to receive any cash  dividends.  Stock  dividends  issued with  respect to
Restricted  Shares will be treated as additional  Shares covered by the grant of
Restricted Shares and will be subject to the same Restrictions.

                                   ARTICLE 10
                               PERFORMANCE AWARDS

         10.1 General.  Performance  Awards  will be  subject  to the  terms and
conditions set forth in Article 6 and this Article 10 and may contain such other
terms and conditions not inconsistent  with the express  provisions of the Plan,
as the Committee (or the Board with respect to Awards to Non-Employee Directors)
deems desirable.

         10.2 Nature of Performance  Awards. A Performance  Award is an Award of
units  (with each unit  having a value  equivalent  to one  Share)  granted to a
Participant  subject  to  such  terms  and  conditions  as the  Committee  deems
appropriate, including, without limitation, the requirement that the Participant
forfeit  such  Performance  Award or a portion  thereof  in the event  specified
performance criteria are not met within a designated period of time.

         10.3 Performance Cycles. For each Performance Award, the Committee will
designate a performance  period (the "Performance  Cycle") with a duration to be
determined by the Committee in its discretion within which specified Performance
Goals are to be attained.  There may be several  Performance Cycles in existence
at any one time and the  duration  of  Performance  Cycles may differ  from each
other.

         10.4 Performance Goals. The Committee will establish  Performance Goals
for each Performance  Cycle on the basis of such criteria and to accomplish such
objectives as the Committee may from time to time select.  Performance Goals may
be based on performance criteria for Corporation,  a Subsidiary, or an operating
group, or based on a Participant's individual performance. Performance Goals may
include  objective and subjective  criteria.  During any Performance  Cycle, the
Committee  may adjust the  Performance  Goals for such  Performance  Cycle as it
deems  equitable in  recognition  of unusual or  nonrecurring  events  affecting
Corporation,  changes in applicable tax laws or accounting  principles,  or such
other factors as the Committee may determine.

EPITOPE, INC.
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<PAGE>

         10.5 Determination of Awards. As soon as practicable after the end of a
Performance  Cycle, the Committee will determine the extent to which Performance
Awards  have  been  earned  on the  basis  of  performance  in  relation  to the
established Performance Goals.

         10.6 Timing  and Form of  Payment.  Settlement  of  earned  Performance
Awards  will be made  to the  Participant  as  soon  as  practicable  after  the
expiration of the  Performance  Cycle and the  Committee's  determination  under
Section 10.5, in the form of cash,  installments,  Shares, Deferred Compensation
Options,  or any  combination  of the  foregoing  or in any  other  form  as the
Committee determines.

         10.7 Performance  Goals for Executive  Officers.  The performance goals
for Performance  Awards granted to executive  officers of Corporation may relate
to corporate performance, business unit performance, or a combination of both.

                   (a)  Corporate  performance  goals will be based on financial
         performance  goals related to the performance of Corporation as a whole
         and  may   include   one  or  more   measures   related  to   earnings,
         profitability,  efficiency,  or return to stockholders such as earnings
         per share, operating profit, stock price, costs of production, or other
         measures.

                   (b)  Business  unit  performance  goals  will be  based  on a
         combination  of  financial  goals and  strategic  goals  related to the
         performance of an identified  business unit for which a Participant has
         responsibility.  Strategic goals for a business unit may include one or
         a combination of objective  factors relating to success in implementing
         strategic plans or  initiatives,  introductory  products,  constructing
         facilities,  or other  identifiable  objectives.  Financial goals for a
         business  unit may  include  the  degree  to which  the  business  unit
         achieves  one or  more  objective  measures  related  to its  revenues,
         earnings,   profitability,   efficiency,  operating  profit,  costs  of
         production, or other measures.

                   (c)  Any corporate or business unit goals may be expressed as
         absolute  amounts or as ratios or percentages.  Success may be measured
         against various standards,  including budget targets,

         improvement  over prior  periods,  and  performance  relative  to other
         companies, business units, or industry groups.

         10.8 Award  Limitations.  The maximum  number of Shares  issuable  with
respect to Performance  Awards granted to any individual  executive  officer may
not exceed 150,000 Shares for any calendar year.

                                   ARTICLE 11
                    OTHER STOCK-BASED AND COMBINATION AWARDS

         11.1 Other Stock-Based Awards. The Committee (or the Board with respect
to Awards to  Non-Employee  Directors)  may grant  other  Awards  under the Plan
pursuant  to which  Shares  are or may in the  future  be  acquired,  or  Awards
denominated in or measured by Share  equivalent  units,  including Awards valued
using  measures  other than the market value of Shares.  Such Other  Stock-Based
Awards may be granted either alone, in addition to, or in tandem with, any other
type of Award granted under the Plan.

         11.2 Combination  Awards. The Committee may also grant Awards under the
Plan in tandem or combination with other Awards or in exchange of Awards,  or in
tandem or combination  with, or as  alternatives  to, grants or rights under any
other employee plan of Corporation,  including the plan of any acquired  entity.
No action  authorized  by this  section  may reduce  the amount of any  existing
benefits or change the terms and conditions  thereof  without the  Participant's
consent.

                                                                   EPITOPE, INC.
                                                                              29
<PAGE>

                                   ARTICLE 12
                               DEFERRAL ELECTIONS

         The Committee may permit a Participant to elect to defer receipt of the
payment of cash or the  delivery of Shares that would  otherwise  be due to such
Participant  by virtue of the  exercise,  earn-out,  or Vesting of an Award made
under the Plan. If any such election is permitted,  the Committee will establish
rules and procedures for such payment deferrals,  including, but not limited to:
(a)  payment or  crediting  of  reasonable  interest  on such  deferred  amounts
credited  in cash,  (b) the payment or  crediting  of  dividend  equivalents  in
respect of  deferrals  credited in Share  equivalent  units,  or (c) granting of
Deferred Compensation Options.

                                   ARTICLE 13
                              DIVIDEND EQUIVALENTS

         Any Awards may,  at the  discretion  of the  Committee,  earn  dividend
equivalents.  In respect of any such  Award  that is  outstanding  on a dividend
record date for Common  Stock,  the  Participant  may be credited with an amount
equal to the amount of cash or stock  dividends that would have been paid on the
Shares  covered  by  such  Award,  had  such  covered  Shares  been  issued  and
outstanding  on such dividend  record date.  The Committee  will  establish such
rules and procedures governing the crediting of dividend equivalents,  including
the  timing,  form of  payment,  and  payment  contingencies  of  such  dividend
equivalents, as it deems appropriate or necessary.

                                   ARTICLE 14
                ADJUSTMENTS UPON CHANGES IN CAPITALIZATION, ETC.

         14.1 Plan Does Not Restrict Corporation.  The existence of the Plan and
the Awards granted hereunder will not affect or restrict in any way the right or
power of the Board or the  shareholders  of Corporation to make or authorize any
adjustment,  recapitalization,  reorganization, or other change in Corporation's
capital  structure  or  its  business,   any  merger  or  consolidation  of  the
Corporation,  any  issue of bonds,  debentures,  preferred  or prior  preference
stocks ahead of or affecting  Corporation's capital stock or the rights thereof,
the  dissolution or liquidation of Corporation or any sale or transfer of all or
any part of its assets or business, or any other corporate act or proceeding.

       14.2 Adjustments  by the  Committee.  In the  event  of any  change  in
capitalization  affecting  the  Common  Stock  of  Corporation,  such as a stock
dividend,  stock  split,  recapitalization,   merger,  consolidation,  split-up,
combination or exchange of shares or other form of reorganization,  or any other
change affecting the Common Stock, such  proportionate  adjustments,  if any, as
the  Committee,  in its sole  discretion,  may deem  appropriate to reflect such
change,  will be made with respect to the  aggregate  number of Shares for which
Awards in respect  thereof may be granted under the Plan,  the maximum number of
Shares  which may be sold or  awarded to any  Participant,  the number of Shares
covered  by each  outstanding  Award,  and the  price per  Share in  respect  of
outstanding  Awards.  The Committee may also make such adjustments in the number
of Shares covered by, and price or other value of any outstanding  Awards in the
event of a spin-off or other distribution (other than normal cash dividends), of
Corporation assets to shareholders.

                                   ARTICLE 15
                            AMENDMENT AND TERMINATION

         The Board may amend,  suspend,  or terminate the Plan or any portion of
the Plan at any time,  provided no  amendment  may be made  without  shareholder
approval  if such  approval  is required  by  applicable  law or the  applicable
requirements of a stock exchange or over-the-counter stock trading system.

                                   ARTICLE 16
                                  MISCELLANEOUS

         16.1 Unfunded Plan. The Plan will be unfunded and Corporation  will not
be  required to  segregate  any assets  that may at any time be  represented  by
Awards under the Plan.  Any liability of  Corporation to any person

EPITOPE, INC.
30
<PAGE>

with  respect  to any  Award  under  the  Plan  will be  based  solely  upon any
contractual  obligations  that may be  effected  pursuant  to the Plan.  No such
obligation  of  Corporation  will be deemed to be  secured  by any pledge of, or
other encumbrance on, any property of Corporation.

         16.2 Payments  to  Trust.  The  Committee  is  authorized  (but  has no
obligation)  to cause to be  established  a trust  agreement  or  several  trust
agreements  whereunder  the  Committee  may make  payments  of amounts due or to
become due to Participants in the Plan.

         16.3 Other Corporation Benefit and Compensation Programs.  Payments and
other  benefits  received by a  Participant  under an Award made pursuant to the
Plan  will  not  be  deemed  a  part  of  a  Participant's  regular,   recurring
compensation  for purposes of the termination  indemnity or severance pay law of
any state or country  and shall not be  included  in, or have any effect on, the
determination  of  benefits  under any other  employee  benefit  plan or similar
arrangement provided by Corporation or a Subsidiary unless expressly so provided
by such other plan or  arrangements,  or except  where the  Committee  expressly
determines that an Award or portion of an Award should be included to accurately
reflect  competitive  compensation  practices or to recognize  that an Award has
been made in lieu of a portion of cash  compensation.  Awards under the Plan may
be made in combination  with or in tandem with, or as  alternatives  to, grants,
awards,   or  payments  under  any  other   Corporation  or  Subsidiary   plans,
arrangements,  or  programs.  The  Plan  notwithstanding,   Corporation  or  any
Subsidiary   may  adopt  such  other   compensation   programs  and   additional
compensation  arrangements as it deems necessary to attract,  retain, and reward
employees and directors for their service with Corporation and its Subsidiaries.

         16.4 Securities  Law  Restrictions.  No Shares may be issued  under the
Plan unless  counsel for  Corporation is satisfied that such issuance will be in
compliance with applicable  federal and state securities laws.  Certificates for
Shares delivered under the Plan may be subject to such stop-transfer  orders and
other  restrictions  as the  Committee  may  deem  advisable  under  the  rules,
regulations,  and other requirements of the Securities and Exchange  Commission,
any  stock  exchange  upon  which  the  Common  Stock  is then  listed,  and any
applicable  federal or state securities law. The Committee may cause a legend or
legends to be put on any such certificates to make appropriate reference to such
restrictions.

         16.5 Governing  Law.  Except with respect to  references to the Code or
federal  securities  laws,  the Plan and all actions taken  thereunder  shall be
governed by and construed in accordance with the laws of the state of Oregon.

                                   ARTICLE 17
                              SHAREHOLDER APPROVAL

         The  Plan is  expressly  subject  to the  approval  of the  Plan by the
shareholders at the 2000 annual meeting of Corporation's shareholders.

                                                                   EPITOPE, INC.
                                                                              31


<PAGE>

PROXY

                                  EPITOPE, INC.
                       2000 ANNUAL MEETING OF SHAREHOLDERS
               PROXY SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS


The undersigned  hereby  appoints  Charles E. Bergeron and Theodore R. Gwin, and
each of them, proxies with full power of substitution, to vote all of the shares
which  the  undersigned  is  entitled  to vote at the  2000  Annual  Meeting  of
Shareholders of Epitope, Inc. (the "Company"),  to be held on Tuesday,  February
15, 2000, and at any  adjournment or adjournments  thereof,  with all the powers
the undersigned would possess if personally present, with respect to the matters
listed on the reverse side.

The shares  represented by this Proxy,  if properly  executed,  will be voted as
specified on the reverse side or, IF NO SPECIFICATION IS MADE, WILL BE VOTED FOR
THE  ELECTION OF THE NOMINEES  LISTED ON THE REVERSE  SIDE AS DIRECTORS  AND FOR
ITEM 2. If any other  business  properly  comes before the meeting,  the proxies
named above will have discretionary authority to vote thereon in accordance with
their best judgment.

          PLEASE MARK, DATE, SIGN, AND RETURN THE PROXY CARD PROMPTLY.
                  (Continued and to be signed on reverse side.)



                              FOLD AND DETACH HERE




                                  EPITOPE, INC.


                       2000 ANNUAL MEETING OF SHAREHOLDERS

                           TUESDAY, FEBRUARY 15, 2000


<PAGE>


         Please mark your votes as indicated in this example [X]


                                                                  FOR   WITHHOLD
1.       Election of Directors                                    [  ]   [  ]
         Class III (Term Expiring 2001)
                  Frank G. Hausmann
         Class I (Term Expiring 2003)
                  W. Charles Armstrong
                  Roger L. Pringle
                  John W. Morgan


(INSTRUCTION: TO WITHHOLD AUTHORITY TO VOTE FOR ANY INDIVIDUAL NOMINEE, MARK FOR
AND STRIKE A LINE  THROUGH THE  NOMINEE'S  NAME IN THE LIST  ABOVE.  TO WITHHOLD
AUTHORITY TO VOTE FOR ALL NOMINEES, MARK WITHHOLD.)

                                                         FOR   AGAINST  ABSTAIN
2.       Approval of Epitope, Inc. 2000 Stock Award Plan [  ]    [  ]     [  ]



Signature(s)                                         Dated:             , 2000
             ------------------------------------          -------------

Please date and sign exactly as your name appears on this Proxy.  If signing for
estates, trusts, partnerships or corporations, name and title or capacity should
be stated. If shares are held jointly, each holder should sign.






                              FOLD AND DETACH HERE




                                  EPITOPE, INC.


                       2000 ANNUAL MEETING OF SHAREHOLDERS

                           TUESDAY, FEBRUARY 15, 2000



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