LEHMAN BROTHERS HOLDINGS INC
SC 13G/A, 1996-11-12
SECURITY BROKERS, DEALERS & FLOTATION COMPANIES
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                          Lehman Brothers Holdings Inc.
                       3 World Financial Center, 24th Floor
                                New York, NY 10285


                          OFFICE OF THE GENERAL COUNSEL


                                                      November 12, 1996



Securities and Exchange Commission
450 Fifth Street, N.W.
Washington, DC 20549

       Attn:  Document Control--EDGAR

       Re:  SCHEDULE 13G AMENDMENT NO. 2


Dear Commissioner:

     On behalf of Lehman  Brothers  Holdings  Inc.  (the  "Reporting  Person"),
submitted in  electronic  form for filing,  is an Amendment No. 2 to a Schedule
13G relating to the Reporting Person's ownership of Advanced Therapeutic Systems
Ltd.

     If you have any questions  regarding  this filing,  please  contact the
undersigned at (212) 526-1911.



                                                      Very truly yours,


                                                      /s/ Karen C. Manson
                                                      -------------------
                                                      Karen C. Manson
                                                      Vice President
                                                      Secretary

Enclosure

cc:      Advanced Therapeutic Systems Ltd.
         American Stock Exchange



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