LEHMAN BROTHERS HOLDINGS INC
SC 13G, 1998-02-13
SECURITY BROKERS, DEALERS & FLOTATION COMPANIES
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SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, D.C. 20549

Schedule 13G

Under the Securities Exchange Act of 1934


Crescendo Pharmaceuticals Corporation                 
(Name of Issuer)

Class A Common Stock
(Title of Class of Securities)

225637107000
(CUSIP Number)

Check the following box if a fee is being paid with this statement.
(   )

The  information  required in the remainder of this cover page (except any items
to which the form provides a cross-reference)  shall not be deemed to be "filed"
for the purpose of Section 18 of the Securities  Exchange Act of 1934 ("Act") or
otherwise  subject to the  liabilities  of that  section of the Act but shall be
subject to all other provisions of the Act.

<PAGE>

CUSIP No.
225637107000

1)  Names of Reporting Person
    Lehman Brothers Holdings Inc.
    S.S. or I.R.S. Identification No. of Above Person
    13-3216325

2)  Check the Appropriate box if a Member of a Group

(a)  ( X ) Sole
(b)  (   ) Joint Filing


3)  SEC Use Only

4)  Citizenship or Place of Organization
    Delaware

Number of Shares Beneficially Owned by Each Reporting Person With:

5)  Sole Voting Power
    248,000

6)  Shared Voting Power
    -0-

7)  Sole Dispositive Power
    248,000

8)  Shared Dispositive Power
    -0-

9)  Aggregate Amount Beneficially Owned by Each Reporting Person
    248,000

10) Check if the Aggregate Amount in Row (9) Excludes Certain Shares
    (---)

11) Percent of Class Represented by Amount in Row 9 5.0%

12) Type of Reporting Person
    HC/CO

<PAGE>

Item 1(a).  Name of Issuer: Crescendo Pharmaceuticals Corporation

Item 1(b).  Address of Issuer's Principal Executive Offices:       
            1454 Page Mill Road 
            Palo Alto, CA 94304

Item 2(a).  Name of Person Filing:
                      Lehman Brothers Holdings Inc.

Item 2(b).  Address of Principal Business Office:
            3 World Financial Center
            New York, NY  10285

Item 2(c).  Citizenship or Place of Organization:
            See Item 4 of cover pages

Item 2(d).  Title of Class of Securities:
            Class A Common Stock

Item 2(e).  CUSIP Number:
            225637107000

Item 3.     Information if statement is filed pursuant to Rules
            13d-1(b) or 13d-2(b):

            The person filing this statement is Lehman Brothers
            Holdings Inc., a parent holding company in accordance with Section
            240.13d1(b)(ii)(G).

Item 4.     Ownership

(a)  Amount Beneficially Owned as of December 31, 1997 
       See Item 9 of cover pages

(b)  Percent of Class: 
       See Item 11 of cover pages

(c)  Number of shares as to which such person has: 
     (i) sole power to vote or to direct  the vote  
     (ii) shared  power to vote or to direct  the vote
     (iii) sole  power to dispose or to direct the  disposition  
     (iv) shared power to dispose or to direct the disposition

     See Items 5-8 of cover pages

<PAGE>

Item 5.   Ownership of Five Percent or Less of a Class 
          Not Applicable.

Item 6.   Ownership of More than Five Percent on Behalf of 
          Another Person 
          Not Applicable.

Item 7.   Identification and Classification of the Subsidiary
          which Acquired the Security being reported on by the
          Parent Holding Company

          The relevant subsidiary is Lehman Brothers Inc., a Broker/Dealer 
          registered  under  Section 15 of the  Securities  Exchange Act of
          1934.

Item 8.   Identification and Classification of Members of the 
          Group
          Not Applicable.


Item 9.   Notice of Dissolution of Group 
          Not Applicable.


Item 10.  Certification

By signing below I certify  that,  to the best of my knowledge  and belief,  the
securities  referred to above were  acquired in the ordinary  course of business
and were not  acquired for the purpose of and do not have the effect of changing
or  influencing  the  control  of the  issuer  of such  securities  and were not
acquired in connection with or as a participant in any  transaction  having such
purposes or effect.


<PAGE>

After  reasonable  inquiry and to the best of the  undersigned's  knowledge  and
belief,  the undersigned hereby certifies that the information set forth in this
statement is true, complete and correct.



Dated:December 31, 1997


LEHMAN BROTHERS HOLDINGS INC.


By:  /s/ Jennifer Marre
    -------------------
Name:  Jennifer Marre
Title: Vice President and Secretary



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