LEHMAN BROTHERS HOLDINGS INC
SC 13G/A, 1999-02-25
SECURITY BROKERS, DEALERS & FLOTATION COMPANIES
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SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, D.C. 20549

Schedule 13G Amendment No. 1

Under the Securities Exchange Act of 1934


Crescendo Pharmaceuticals Corporation 
(Name of Issuer)

Class A Common Stock
(Title of Class of Securities)

225637107000
(CUSIP Number)

Check the following box if a fee is being paid with this statement.
(   )

The information required in the remainder of this cover page (except any items
to which the form provides a cross-reference) shall not be deemed to be "filed"
for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or
otherwise  subject to the liabilities  of that section of the Act but shall be
subject to all other provisions of the Act.


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CUSIP No.
225637107000

1)   Names of Reporting Person
     Lehman Brothers Holdings Inc.
     S.S. or I.R.S. Identification No. of Above Person
     13-3216325

2)   Check the Appropriate box if a Member of a Group

(a)  ( X ) Sole
(b)  (   ) Joint Filing


3)   SEC Use Only

4)   Citizenship or Place of Organization
     Delaware

Number of Shares Beneficially Owned by Each Reporting Person With:

5)   Sole Voting Power
     313,458

6)   Shared Voting Power
     -0-

7)   Sole Dispositive Power
     313,458

8)   Shared Dispositive Power
     -0-

9)   Aggregate Amount Beneficially Owned by Each Reporting Person
     313,458

10)  Check if the Aggregate Amount in Row (9) Excludes Certain Shares
     (---)

11)  Percent of Class Represented by Amount in Row 9
     6.3%

12)  Type of Reporting Person
     HC/CO

<PAGE>

Item 1(a).  Name of Issuer:  Crescendo Pharmaceuticals Corporation

Item 1(b).  Address of Issuer's Principal Executive Offices: 
            1454 Page Mill Road
            Palo Alto, CA 94304

Item 2(a).  Name of Person Filing:
            Lehman Brothers Holdings Inc.

Item 2(b).  Address of Principal Business Office:
            3 World Financial Center
            New York, NY  10285

Item 2(c).  Citizenship or Place of Organization:
            See Item 4 of cover pages

Item 2(d).  Title of Class of Securities:
            Class A Common Stock

Item 2(e).  CUSIP Number:
            225637107000

Item 3.     Information if statement is filed pursuant to Rules 13d-1(b) or
            13d-2(b):

            The person filing this statement is Lehman Brothers Holdings Inc., a
            parent holding company in accordance with Section 240.13d1(b)(ii)
            (G).

Item 4.     Ownership

(a)       Amount Beneficially Owned as of December 31, 1998 
          See Item 9 of cover pages

(b)       Percent of Class:
          See Item 11 of cover pages

(c)       Number of shares as to which such person has:
          (i) sole power to vote or to direct the vote 
          (ii) shared power to vote or to direct the vote
          (iii)sole power to dispose or to direct the disposition
          (iv) shared power to dispose or to direct the disposition

          See Items 5-8 of cover pages

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Item 5.   Ownership of Five Percent or Less of a Class
          Not Applicable.

Item 6.   Ownership of More than Five Percent on Behalf of Another Person
          Not Applicable.

Item 7.   Identification and Classification of the Subsidiary which Acquired 
          the Security being reported on by the Parent Holding Company

          The relevant subsidiary is Lehman Brothers Inc.,  a
          Broker/Dealer registered under Section 15 of the Securities
          Exchange Act of 1934.


Item 8.   Identification and Classification of Members of the Group
          Not Applicable.


Item 9.   Notice of Dissolution of Group
          Not Applicable.

Item 10.  Certification

By signing below I certify  that,  to the best of my knowledge and belief,  the
securities referred to above were acquired in the ordinary  course of business
and were not acquired for the purpose of and do not have the effect of changing
or influencing the control of the  issuer of such securities and were not
acquired in connection with or as a participant in any transaction having such
purposes or effect.

<PAGE>

After reasonable inquiry and to the best of the undersigned's knowledge and
belief, the undersigned hereby certifies that the information set forth in this
statement is true, complete and correct.



Dated:December 31, 1998


LEHMAN BROTHERS HOLDINGS INC.


By:  /s/ Jennifer Marre
     ------------------
Name:  Jennifer Marre
Title: Vice President and
       Secretary




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