OPPENHEIMER GLOBAL BIO TECH FUND
497, 1994-08-19
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               OPPENHEIMER GLOBAL BIO-TECH FUND
               Supplement dated August 19, 1994
           to the Prospectus dated February 1, 1994

The Prospectus is amended as follows:

1. The Prospectus supplements dated June 22, 1994 and July 5, 1994 are hereby
replaced with this supplement.

2. The second paragraph under the section of the Prospectus entitled "Management
of the Fund" on page 10 is deleted and replaced by the following:

   James Ayer is an Assistant Vice President of the Manager who serves as a Vice
   President and Portfolio Manager of the Fund.  Since August, 1994, he has been
   the person principally responsible for the day-to-day management of the 
   Fund's portfolio. He also serves as an officer and portfolio manager for 
   other OppenheimerFunds. Previously he was an International Equities 
   Investment Officer with Brown Brothers Harriman & Company.

3. The second paragraph under the caption "How To Buy Shares -- Minimum 
Investment" on page 11 is deleted and replaced with the following:

   Shares of the Fund are not available for sale to new investors, including
   shares purchased by exchange from "Eligible Funds" (defined below), 
   lump-sum purchases, and purchases under an Asset Builder Plan (described 
   below) or by reinvestment of dividends or distributions from other 
   "Eligible Funds," or under the "Reinvestment Privilege," described below.
   Existing Fund shareholders may purchase Fund shares in amounts up to $25,000
   per investor per month, including within that limit shares purchased by 
   exchange from "Eligible Funds," lump-sum purchases, and purchases
   under an Asset Builder Plan or by reinvestment of dividends or 
   distributions from other "Eligible Funds," or under the "Reinvestment 
   Privilege."  The $25,000 monthly limit on purchases described
   in the previous sentence does not apply to purchases of shares
   in the amount of $1 million or more by an "institutional investor." The 
   determination as to whether a particular investor is an "institutional 
   investor" shall be made by the Distributor, in its sole discretion,
   based upon information provided to it at the time of
   purchase by the investor or the investor's dealer and which is 
   satisfactory to the Distributor.  The foregoing is subject to the right
   of the Fund and the Distributor, in their complete discretion, to modify 
   or terminate the terms of this offer at any time without prior notice.
   The remaining sections of this Prospectus are hereby amended to
   conform to the terms of this offer.

                                      (continued on other side)

4. The Fund's Board of Trustees has unanimously approved and recommended 
that the Fund's shareholders approve the Manager's proposal that 
the Fund be restructured.  Shareholders of the Fund will be asked, at a 
meeting currently scheduled for September 19, 1994, to approve a
proposal to broaden the Fund's current investment policy that it will 
normally invest at least 65% of its total assets in securities of biotechnology
companies located worldwide so that the Fund may emphasize investments 
in securities of emerging growth companies located worldwide.

   If the Fund's shareholders approve this proposal, the Board anticipates 
that it will change the Fund's name accordingly.  A proxy statement and other 
soliciting materials describing the proposal in more detail was mailed 
in early August, 1994 to shareholders of record as of July 15,
1994, the record date for the shareholders meeting.  Shareholders of the
Fund that first acquired Fund shares after the record date for the 
shareholders meeting will not be entitled to vote on the proposal.


August 19, 1994                                           PS750








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