MORGAN STANLEY INSTITUTIONAL FUND INC
497, 1996-09-06
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<PAGE>
                        SUPPLEMENT DATED AUGUST 30, 1996
                     TO THE PROSPECTUS DATED MAY 1, 1996 OF
 
                    MORGAN STANLEY INSTITUTIONAL FUND, INC.
                                 P.O. BOX 2798
                             BOSTON, MASSACHUSETTS
                                   02208-2798
                                 -------------
 
    The  prospectus dated  May 1, 1996  (the "Prospectus")  of the International
Magnum Portfolio of the Morgan Stanley Institutional Fund, Inc. (the "Fund")  is
hereby amended and supplemented as follows:
 
    The  following  section  is  added  before  the  section  under  the heading
"PROSPECTUS SUMMARY:"
 
                              FINANCIAL HIGHLIGHTS
 
    The following  table provides  financial  highlights for  the  International
Magnum  Portfolio for the period  ended July 31, 1996 and  is part of the Fund's
unaudited financial statements  which are  included in the  Fund's Statement  of
Additional  Information (the "SAI").  The SAI is  available at no  cost from the
Fund at  the address  and  telephone number  noted on  the  cover page  of  this
Prospectus.  The following  information should be  read in  conjunction with the
financial statements and notes thereto.
 
<TABLE>
<CAPTION>
                                                                                              CLASS A    CLASS B
                                                                                             ---------  ---------
                                                                                                 PERIOD FROM
                                                                                              MARCH 15, 1996* TO
                                                                                                JULY 31, 1996
                                                                                                 (UNAUDITED)
                                                                                             --------------------
<S>                                                                                          <C>        <C>
NET ASSET VALUE, BEGINNING OF PERIOD.......................................................  $   10.00  $   10.00
                                                                                             ---------  ---------
INCOME FROM INVESTMENT OPERATIONS
    Net Investment Income (1)..............................................................       0.03       0.03
    Net Realized and Unrealized Loss on Investments........................................      (0.06)     (0.08)
                                                                                             ---------  ---------
      Total from Investment Operations.....................................................      (0.03)     (0.05)
                                                                                             ---------  ---------
NET ASSET VALUE, END OF PERIOD.............................................................  $    9.97  $    9.95
                                                                                             ---------  ---------
                                                                                             ---------  ---------
TOTAL RETURN...............................................................................      (0.30)%     (0.50)%
                                                                                             ---------  ---------
                                                                                             ---------  ---------
RATIOS AND SUPPLEMENTAL DATA:
Net Assets, End of Period (Thousands)......................................................  $  65,939  $   2,395
Ratio of Expenses to Average Net Assets (1)................................................       1.00%**      1.25%**
Ratio of Net Investment Income to Average Net Assets (1)...................................       1.71%**      1.66%**
Portfolio Turnover Rate....................................................................          3%         3%
Average Commission Rate....................................................................  $  0.0391  $  0.0391
- --------------------------
(1) Effect of voluntary expense limitation during the period:
      Per share benefit to net investment income...........................................  $    0.02  $    0.02
    Ratios before expense limitation:
      Expenses to Average Net Assets.......................................................       2.15%**      2.68%**
      Net Investment Income to Average Net Assets..........................................       0.56%**      0.23%**
 * Commencement of Operations
** Annualized
</TABLE>


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