CORTEX PHARMACEUTICALS INC/DE/
SC 13D/A, 1996-09-06
PHARMACEUTICAL PREPARATIONS
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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13D

                    Under the Securities Exchange Act of 1934
                               (Amendment No. 1)*

                          CORTEX PHARMACEUTICALS, INC.
                     -------------------------------------
                                (Name of Issuer)

                         Common Stock, $0.001 Par Value
                     --------------------------------------
                         (Title of Class of Securities)

                                    22054300
                              -------------------
                                 (CUSIP Number)

                              Stephen M. Vine, Esq.
                    Akin, Gump, Strauss, Hauer & Feld, L.L.P.
                                 399 Park Avenue
                            New York, New York 10022
                                 (212) 872-1000
                   -----------------------------------------
                  (Name, Address and Telephone Number of Person
                Authorized to Receive Notices and Communications)

                                September 5, 1996
                        --------------------------------
                      (Date of Event which Requires Filing
                               of this Statement)

If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  which is the subject of this  Schedule 13D, and is filing this
schedule because of Rule 13d-1(b)(3) or (4), check the following box [_].

Check the  following  box if a fee is being paid with the statement [_] . (A fee
is not required only if the reporting  person:  (1) has a previous  statement on
file  reporting  beneficial  ownership of more than five percent of the class of
securities  described  in Item 1;  and (2) has  filed  no  amendment  subsequent
thereto reporting  beneficial  ownership of five percent or less of such class.)
(See Rule 13d-7)

Note: Six copies of this statement, including all exhibits, should be filed with
the  Commission.  See Rule 13d- 1(a) for other  parties to whom copies are to be
sent.

*The  remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter disclosure
provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).

                         Continued on following page(s)
                                Page 1 of 9 Pages
                              Exhibit Index: Page 9


<PAGE>



                                  SCHEDULE 13D

CUSIP No. 22054300                                             Page 2 of 9 Pages

1       Name of Reporting Person
        S.S. or I.R.S. Identification No. of Above Person

               George  Soros (in his  capacity as the sole  proprietor  of Soros
               Fund Management)

2       Check the Appropriate Box If a Member of a Group*
                                            a.  [_]
                                            b.  [_]

3       SEC Use Only

4       Source of Funds*

               Not applicable

5       Check Box If Disclosure of Legal Proceedings Is Required Pursuant to 
        Items 2(d) or 2(e)  [_]

6       Citizenship or Place of Organization

               United States

                      7      Sole Voting Power
 Number of                          1,050,000
   Shares
Beneficially          8      Shared Voting Power
  Owned By                          0
    Each
  Reporting           9      Sole Dispositive Power
   Person                           1,050,000
    With
                      10     Shared Dispositive Power
                                    0

11      Aggregate Amount Beneficially Owned by Each Reporting Person

                                    1,050,000

12      Check Box If the Aggregate Amount in Row (11) Excludes Certain Shares*
        [_]

13      Percent of Class Represented By Amount in Row (11)

                             14.16%

14      Type of Reporting Person*

               IA; IN

                      *SEE INSTRUCTIONS BEFORE FILLING OUT!


<PAGE>


                                                               Page 3 of 9 Pages


               This  Amendment No. 1 to Schedule 13D relates to shares of Common
Stock,  $0.001 par value per share (the  "Shares"),  of Cortex  Pharmaceuticals,
Inc.  (the  "Issuer").  This  Amendment  No. 1 amends the initial  statement  on
Schedule 13D dated  November  12, 1993 (the  "Initial  Statement")  filed by the
Reporting Person (as defined herein). This Amendment No. 1 is being filed by the
Reporting  Person  voluntarily to report that, as a result of an increase in the
number of outstanding Shares of the Issuer, the percentage of outstanding Shares
held for the account of Quantum  Partners LDC, a Cayman Islands exempted limited
duration  company  ("Quantum  Partners"),  has  decreased.  This Amendment No. 1
amends and restates all previous  filings on Schedule 13D relating to the Shares
as it is the first Schedule 13D filed on EDGAR.

Item 1.        Security and Issuer.

               This Amendment No. 1 to Schedule 13D relates to the Shares of the
Issuer.  The address of the principal  executive  offices of the Issuer is 15241
Barranca Parkway, Irvine, California 92718.

Item 2.        Identity and Background.

               This  statement is being filed on behalf of Mr. George Soros (the
"Reporting  Person") in his  capacity as the sole  proprietor  of an  investment
advisory firm conducting  business under the name Soros Fund Management ("SFM").
This statement relates to Shares held for the account of Quantum Partners, which
has granted  investment  discretion  to SFM pursuant to an  investment  advisory
contract. SFM is a sole proprietorship of which the Reporting Person is the sole
proprietor.  SFM has its principal office at 888 Seventh Avenue, 33rd Floor, New
York, New York 10106.  Its sole business is to serve,  pursuant to contract,  as
the principal  investment manager to several foreign  investment  companies (the
"SFM Clients"),  including Quantum Partners.  Quantum Partners has its principal
office at Kaya Flamboyan 9, Willemstad,  Curacao,  Netherlands  Antilles.  SFM's
contracts  with  SFM  Clients  generally  provide  that SFM is  responsible  for
designing and  implementing the SFM Clients' overall  investment  strategy;  for
conducting  direct  portfolio  management  strategies  to the  extent  that  SFM
determines  that it is  appropriate  to  utilize  its own  portfolio  management
capabilities; for selecting, evaluating and monitoring other investment advisors
who manage separate portfolios on behalf of SFM Clients;  and for allocating and
reallocating the SFM Clients' assets among the outside managers and itself.

               The principal occupation of the Reporting Person, a United States
citizen,  is his direction of the activities of SFM, which is carried out in his
capacity as the sole  proprietor of SFM at SFM's principal  office.  Information
concerning the identity and  background of the Managing  Directors of SFM is set
forth in Annex A hereto and  incorporated  by reference in response to this Item
2.

               Pursuant to  regulations  promulgated  under Section 13(d) of the
Act, the Reporting  Person (as the sole proprietor and the person  ultimately in
control of SFM) may be deemed a beneficial  owner of  securities,  including the
Shares,  held for the account of Quantum Partners as a result of the contractual
authority of SFM to exercise voting and  dispositive  power with respect to such
securities.

               During the past five years, none of the Reporting Person, Quantum
Partners and, to the best of the Reporting Person's knowledge,  any other person
identified  in  response  to this Item 2 has been (a)  convicted  in a  criminal
proceeding,  or (b) a party to any civil  proceeding as a result of which he has



<PAGE>


                                                               Page 4 of 9 Pages

been subject to a judgment,  decree or final order enjoining  future  violations
of,  or  prohibiting  or  mandating  activities  subject  to,  federal  or state
securities laws, or finding any violation with respect to such laws.

Item 3.        Source and Amount of Funds or Other Consideration.

               Quantum Partners initially expended  approximately  $5,500,000.00
of its working capital to purchase  5,500,000  Shares pursuant to the terms of a
Purchase  Agreement  dated as of November 5, 1993 between the Issuer and Quantum
Partners (the "Purchase Agreement"), which was filed as Exhibit B to the Initial
Statement  and is  incorporated  by  reference  in  response  to this Item 3. In
January  1995,  the Issuer  undertook a  one-for-five  reverse stock split which
resulted in  1,100,000  Shares  being held for the  account of Quantum  Partners
after such reverse stock split,  prior to dispositions of an aggregate of 50,000
Shares, which dispositions occurred more than 60 days prior to the date hereof.

               The Shares held for the account of Quantum  Partners  may be held
through margin accounts  maintained with brokers,  which extend margin credit as
and when required to open or carry positions in its margin accounts,  subject to
applicable  federal  margin  regulations,  stock  exchange rules and such firm's
credit  policies.  The  positions  which  may be  held in the  margin  accounts,
including the Shares,  are pledged as  collateral  security for the repayment of
debit balances in the respective accounts.

Item 4.        Purpose of Transaction.

               All of the Shares  reported herein as having been acquired for or
disposed of from the account of Quantum  Partners  were  acquired or disposed of
for investment purposes.  Neither Quantum Partners, the Reporting Person nor, to
the best of his knowledge,  any of the other individuals  identified in response
to Item 2, has any plans or  proposals  that relate to or would result in any of
the  transactions  described  in  subparagraphs  (a)  through  (j) of  Item 4 of
Schedule  13D. The  Reporting  Person  reserves the right to acquire  additional
securities  of the  Issuer,  to  dispose  of such  securities  at any time or to
formulate other purposes,  plans or proposals regarding the Issuer or any of its
securities,  to the extent deemed  advisable in light of general  investment and
trading policies of SFM Clients, market conditions or other factors.

Item 5.        Interest in Securities of the Issuer.

               (a) The aggregate  number of Shares of which the Reporting Person
may be deemed the beneficial owner is 1,050,000 Shares  (approximately 14.16% of
the total number of Shares outstanding).

               (b)  Pursuant  to the  terms  of  the  contract  between  Quantum
Partners  and SFM,  the  Reporting  Person  may be deemed to have sole  power to
direct the voting and  disposition of the 1,050,000  Shares held for the account
of Quantum Partners.

               (c) There have been no transactions  effected with respect to the
Shares since July 7, 1996 (60 days prior to the date hereof) by Quantum Partners
or the Reporting Person.



<PAGE>


                                                               Page 5 of 9 Pages


               (d) The  shareholders  of  Quantum  Partners  have  the  right to
participate  in the receipt of  dividends  from,  or proceeds  from the sale of,
securities,  including the Shares,  held for the account of Quantum  Partners in
accordance with their ownership interests in Quantum Partners.

               (e)    Not applicable.

Item 6.        Contracts, Arrangements,  Understandings in Relationship with 
               Respect to Securities of the Issuer.

               From time to time, the Reporting  Person and/or Quantum  Partners
may lend portfolio securities to brokers, banks or other financial institutions.
These loans  typically  obligate  the borrower to return the  securities,  or an
equal  amount of  securities  of the same  class,  to the lender  and  typically
provide  that the borrower is entitled to exercise  voting  rights and to retain
dividends during the term of the loan. From time to time to the extent permitted
by  applicable  laws,  Quantum  Partners  and/or  other SFM  Clients  may borrow
securities,  including the Shares, for the purpose of effecting, and may effect,
short sale transactions,  and may purchase securities for the purpose of closing
out short positions in such securities.

               Except as disclosed  above and in the Purchase  Agreement,  which
was filed as Exhibit B to the Initial Statement and is incorporated by reference
in response to this Item 6, the  Reporting  Person does not have any  contracts,
arrangements,  understandings or relationships with respect to any securities of
the Issuer.

Item 7.        Material to be Filed as Exhibits.

               (a) Power of Attorney  dated April 16, 1996 granted by Mr. George
Soros in favor of Mr. Sean C. Warren.

               (b) Purchase Agreement dated November 5, 1993, between the Issuer
and  Quantum  Partners  (filed  as  Exhibit  B  to  the  Initial  Statement  and
incorporated herein by reference).


<PAGE>


                                                               Page 6 of 9 Pages


                                   SIGNATURES

               After  reasonable  inquiry  and to the best of my  knowledge  and
belief,  the  undersigned  certifies  that  the  information  set  forth in this
statement is true, complete and correct.

Date:  September 5, 1996                           GEORGE SOROS


                                            By:    /S/ SEAN C. WARREN
                                                   --------------------------
                                                   Sean C. Warren
                                                   Attorney-in-Fact



<PAGE>


                                                               Page 7 of 9 Pages


                                     ANNEX A


               The  following  is a list  of all of the  persons  who  serve  as
Managing Directors of Soros Fund Management ("SFM"):

                              Scott K. H. Bessent
                              Walter Burlock
                              Stanley Druckenmiller
                              Jeffrey L. Feinberg
                              Arminio Fraga
                              Gary Gladstein
                              Robert K. Jermain
                              David N. Kowitz
                              Elizabeth Larson
                              Alexander C. McAree
                              Paul McNulty
                              Gabriel S. Nechamkin
                              Steven Okin
                              Dale Precoda
                              Lief D. Rosenblatt
                              Mark D. Sonnino
                              Filiberto H. Verticelli
                              Sean C. Warren

Each of the  above-listed  persons is a United States  citizen  whose  principal
occupation  is  serving as  Managing  Director  of SFM,  and each has a business
address c/o Soros Fund Management, 888 Seventh Avenue, New York, New York 10106.
During  the past  five  years,  none of the  above-listed  persons  has been (i)
convicted in a criminal proceeding, or (ii) a party to any civil proceeding as a
result of which any such persons has been subject to a judgment, decree or final
order  enjoining  future  violations of, or prohibiting or mandating  activities
subject to, federal or state  securities  laws, or finding any  violations  with
respect to such laws.



<PAGE>


                                                               Page 8 of 9 Pages



                                INDEX OF EXHIBITS

EXHIBIT                                                                 PAGE

    A       Power of Attorney dated April 16, 1996 granted by
            Mr. George Soros in favor of Mr. Sean C. Warren               9






                                                               Page 9 of 9 Pages

                                    EXHIBIT A

                                POWER OF ATTORNEY

KNOW ALL MEN BY THESE PRESENT, that I, GEORGE SOROS, hereby make, constitute and
appoint  SEAN C.  WARREN as my agent and  attorney  in fact for the  purpose  of
executing  in my  name,  in my  personal  capacity  or in my  capacity  as  sole
proprietor of Soros Fund Management, all documents,  certificates,  instruments,
statements,  filings and agreements  ("documents") to be filed with or delivered
to any  foreign or  domestic  governmental  or  regulatory  body or  required or
requested  by any other  person or entity  pursuant  to any legal or  regulatory
requirement relating to the acquisition, ownership, management or disposition of
securities or other  investments,  and any other documents relating or ancillary
thereto,  including but not limited to, all  documents  relating to filings with
the United States Securities and Exchange Commission (the "SEC") pursuant to the
Securities  Act of 1933 or the  Securities  Exchange Act of 1934 (the "Act") and
the rules and regulations promulgated thereunder,  including:  (1) all documents
relating to the beneficial ownership of securities required to be filed with the
SEC pursuant to Section  13(d) or Section  16(a) of the Act  including,  without
limitation:  (a) any acquisition  statements on Schedule 13D or Schedule 13G and
any  amendments  thereto,  (b) any  joint  filing  agreements  pursuant  to Rule
13d-1(f)  and (c) any  initial  statements  of, or  statements  of  changes  in,
beneficial  ownership  of  securities  on Form  3,  Form 4 or Form 5 and (2) any
information statements on Form 13F required to be filed with the SEC pursuant to
Section 13(f) of the Act.

All past acts of the attorney-in-fact in furtherance of the foregoing are hereby
ratified and confirmed.

This power of attorney shall be valid from the date hereof until revoked by me.

IN WITNESS WHEREOF, I have executed this instrument this 16th of April, 1996.



                                               /s/ George Soros
                                               ---------------------------   
                                               GEORGE SOROS




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