<PAGE>
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
SCHEDULE 13G
Under the Securities Exchange Act of 1934
(Amendment No. )*
Virus Research Institute, Inc.
- --------------------------------------------------------------------------------
(Name of Issuer)
Common Stock, $.001 par value
- --------------------------------------------------------------------------------
(Title of Class of Securities)
927920108
----------------------------
(CUSIP Number)
Check the following box if a fee is being paid with this statement|X|. (A fee is
not required only if the filing person: (1) has a previous statement on file
reporting beneficial ownership of more than five percent of the class of
securities described in Item 1; and (2) has filed no amendment subsequent
thereto reporting beneficial ownership of five percent or less of such class.)
(See Rule 13d-7.)
* The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.
The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).
(Continued on following page(s))
Page 1 of 16 Pages
<PAGE>
- ---------------------- --------------------
CUSIP No. 927920108 13G Page 2 of 16 Pages
- ---------------------- --------------------
- --------------------------------------------------------------------------------
1 NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
HealthCare Ventures II, L.P.
- --------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
(a) |_|
(b) |_|
- --------------------------------------------------------------------------------
3 SEC USE ONLY
- --------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
- --------------------------------------------------------------------------------
NUMBER OF SOLE VOTING POWER
SHARES 5
-----------------------------------------------------------
BENEFICIALLY 6 SHARED VOTING POWER
OWNED BY 1,324,975
-----------------------------------------------------------
EACH
7 SOLE DISPOSITIVE POWER
REPORTING
-----------------------------------------------------------
PERSON WITH 8 SHARED DISPOSITIVE POWER
1,324,975
- --------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
1,324,975
- --------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
|_|
- --------------------------------------------------------------------------------
11 PERCENTAGE CLASS REPRESENTED BY AMOUNT IN ROW 9
15%
- --------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
PN
- --------------------------------------------------------------------------------
*SEE INSTRUCTIONS BEFORE FILLING OUT!
<PAGE>
- ---------------------- --------------------
CUSIP No. 927920108 13G Page 3 of 16 Pages
- ---------------------- --------------------
- --------------------------------------------------------------------------------
1 NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
HealthCare Partners II, L.P.
- --------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
(a) |_|
(b) |_|
- --------------------------------------------------------------------------------
3 SEC USE ONLY
- --------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
- --------------------------------------------------------------------------------
NUMBER OF SOLE VOTING POWER
SHARES 5
-----------------------------------------------------------
BENEFICIALLY 6 SHARED VOTING POWER
OWNED BY 1,324,975
-----------------------------------------------------------
EACH
7 SOLE DISPOSITIVE POWER
REPORTING
-----------------------------------------------------------
PERSON WITH 8 SHARED DISPOSITIVE POWER
1,324,975
- --------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
1,324,975
- --------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
|_|
- --------------------------------------------------------------------------------
11 PERCENTAGE CLASS REPRESENTED BY AMOUNT IN ROW 9
15%
- --------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
PN
- --------------------------------------------------------------------------------
*SEE INSTRUCTIONS BEFORE FILLING OUT!
<PAGE>
- ---------------------- --------------------
CUSIP No. 927920108 13G Page 4 of 16 Pages
- ---------------------- --------------------
- --------------------------------------------------------------------------------
1 NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
HealthCare Ventures III, L.P.
- --------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
(a) |_|
(b) |_|
- --------------------------------------------------------------------------------
3 SEC USE ONLY
- --------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
- --------------------------------------------------------------------------------
NUMBER OF SOLE VOTING POWER
SHARES 5
-----------------------------------------------------------
BENEFICIALLY 6 SHARED VOTING POWER
OWNED BY 1,174,575
-----------------------------------------------------------
EACH
7 SOLE DISPOSITIVE POWER
REPORTING
-----------------------------------------------------------
PERSON WITH 8 SHARED DISPOSITIVE POWER
1,174,575
- --------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
1,174,575
- --------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
|_|
- --------------------------------------------------------------------------------
11 PERCENTAGE CLASS REPRESENTED BY AMOUNT IN ROW 9
13.3%
- --------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
PN
- --------------------------------------------------------------------------------
*SEE INSTRUCTIONS BEFORE FILLING OUT!
<PAGE>
- ---------------------- --------------------
CUSIP No. 927920108 13G Page 5 of 16 Pages
- ---------------------- --------------------
- --------------------------------------------------------------------------------
1 NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
HealthCare Partners III, L.P.
- --------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
(a) |_|
(b) |_|
- --------------------------------------------------------------------------------
3 SEC USE ONLY
- --------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
- --------------------------------------------------------------------------------
NUMBER OF SOLE VOTING POWER
SHARES 5
-----------------------------------------------------------
BENEFICIALLY 6 SHARED VOTING POWER
OWNED BY 1,174,575
-----------------------------------------------------------
EACH
7 SOLE DISPOSITIVE POWER
REPORTING
-----------------------------------------------------------
PERSON WITH 8 SHARED DISPOSITIVE POWER
1,174,575
- --------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
1,174,575
- --------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
|_|
- --------------------------------------------------------------------------------
11 PERCENTAGE CLASS REPRESENTED BY AMOUNT IN ROW 9
13.3%
- --------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
PN
- --------------------------------------------------------------------------------
*SEE INSTRUCTIONS BEFORE FILLING OUT!
<PAGE>
- ---------------------- --------------------
CUSIP No. 927920108 13G Page 6 of 16 Pages
- ---------------------- --------------------
- --------------------------------------------------------------------------------
1 NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
HealthCare Ventures IV, L.P.
- --------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
(a) |_|
(b) |_|
- --------------------------------------------------------------------------------
3 SEC USE ONLY
- --------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
- --------------------------------------------------------------------------------
NUMBER OF SOLE VOTING POWER
SHARES 5
-----------------------------------------------------------
BENEFICIALLY 6 SHARED VOTING POWER
OWNED BY 344,928
-----------------------------------------------------------
EACH
7 SOLE DISPOSITIVE POWER
REPORTING
-----------------------------------------------------------
PERSON WITH 8 SHARED DISPOSITIVE POWER
344,928
- --------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
344,928
- --------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
|_|
- --------------------------------------------------------------------------------
11 PERCENTAGE CLASS REPRESENTED BY AMOUNT IN ROW 9
4.0%
- --------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
PN
- --------------------------------------------------------------------------------
*SEE INSTRUCTIONS BEFORE FILLING OUT!
<PAGE>
- ---------------------- --------------------
CUSIP No. 927920108 13G Page 7 of 16 Pages
- ---------------------- --------------------
- --------------------------------------------------------------------------------
1 NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
HealthCare Partners IV, L.P.
- --------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
(a) |_|
(b) |_|
- --------------------------------------------------------------------------------
3 SEC USE ONLY
- --------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
- --------------------------------------------------------------------------------
NUMBER OF SOLE VOTING POWER
SHARES 5
-----------------------------------------------------------
BENEFICIALLY 6 SHARED VOTING POWER
OWNED BY 344,928
-----------------------------------------------------------
EACH
7 SOLE DISPOSITIVE POWER
REPORTING
-----------------------------------------------------------
PERSON WITH 8 SHARED DISPOSITIVE POWER
344,928
- --------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
344,928
- --------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
|_|
- --------------------------------------------------------------------------------
11 PERCENTAGE CLASS REPRESENTED BY AMOUNT IN ROW 9
4.0%
- --------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
PN
- --------------------------------------------------------------------------------
*SEE INSTRUCTIONS BEFORE FILLING OUT!
<PAGE>
- ---------------------- --------------------
CUSIP No. 927920108 13G Page 8 of 16 Pages
- ---------------------- --------------------
- --------------------------------------------------------------------------------
1 NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
James H. Cavanaugh, Ph.D.
- --------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
(a) |_|
(b) |_|
- --------------------------------------------------------------------------------
3 SEC USE ONLY
- --------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
United States
- --------------------------------------------------------------------------------
NUMBER OF SOLE VOTING POWER
SHARES 5
-----------------------------------------------------------
BENEFICIALLY 6 SHARED VOTING POWER
OWNED BY 2,844,478
-----------------------------------------------------------
EACH
7 SOLE DISPOSITIVE POWER
REPORTING
-----------------------------------------------------------
PERSON WITH 8 SHARED DISPOSITIVE POWER
2,844,478
- --------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
2,844,478
- --------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
|_|
- --------------------------------------------------------------------------------
11 PERCENTAGE CLASS REPRESENTED BY AMOUNT IN ROW 9
32.1%
- --------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
IN
- --------------------------------------------------------------------------------
*SEE INSTRUCTIONS BEFORE FILLING OUT!
<PAGE>
- ---------------------- --------------------
CUSIP No. 927920108 13G Page 9 of 16 Pages
- ---------------------- --------------------
- --------------------------------------------------------------------------------
1 NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
Harold R. Werner
- --------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
(a) |_|
(b) |_|
- --------------------------------------------------------------------------------
3 SEC USE ONLY
- --------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
United States
- --------------------------------------------------------------------------------
NUMBER OF SOLE VOTING POWER
SHARES 5
-----------------------------------------------------------
BENEFICIALLY 6 SHARED VOTING POWER
OWNED BY 2,844,478
-----------------------------------------------------------
EACH
7 SOLE DISPOSITIVE POWER
REPORTING
-----------------------------------------------------------
PERSON WITH 8 SHARED DISPOSITIVE POWER
2,844,478
- --------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
2,844,478
- --------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
|_|
- --------------------------------------------------------------------------------
11 PERCENTAGE CLASS REPRESENTED BY AMOUNT IN ROW 9
32.1%
- --------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
IN
- --------------------------------------------------------------------------------
*SEE INSTRUCTIONS BEFORE FILLING OUT!
<PAGE>
- ---------------------- --------------------
CUSIP No. 927920108 13G Page 10 of 16 Pages
- ---------------------- --------------------
- --------------------------------------------------------------------------------
1 NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
William Crouse
- --------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
(a) |_|
(b) |_|
- --------------------------------------------------------------------------------
3 SEC USE ONLY
- --------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
United States
- --------------------------------------------------------------------------------
NUMBER OF SOLE VOTING POWER
SHARES 5
-----------------------------------------------------------
BENEFICIALLY 6 SHARED VOTING POWER
OWNED BY 2,844,478
-----------------------------------------------------------
EACH
7 SOLE DISPOSITIVE POWER
REPORTING
-----------------------------------------------------------
PERSON WITH 8 SHARED DISPOSITIVE POWER
2,844,478
- --------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
2,844,478
- --------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
|_|
- --------------------------------------------------------------------------------
11 PERCENTAGE CLASS REPRESENTED BY AMOUNT IN ROW 9
32.1%
- --------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
IN
- --------------------------------------------------------------------------------
*SEE INSTRUCTIONS BEFORE FILLING OUT!
<PAGE>
- ---------------------- --------------------
CUSIP No. 927920108 13G Page 11 of 16 Pages
- ---------------------- --------------------
- --------------------------------------------------------------------------------
1 NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
John W. Littlechild
- --------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
(a) |_|
(b) |_|
- --------------------------------------------------------------------------------
3 SEC USE ONLY
- --------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
United States
- --------------------------------------------------------------------------------
NUMBER OF SOLE VOTING POWER
SHARES 5
-----------------------------------------------------------
BENEFICIALLY 6 SHARED VOTING POWER
OWNED BY 2,844,478
-----------------------------------------------------------
EACH
7 SOLE DISPOSITIVE POWER
REPORTING
-----------------------------------------------------------
PERSON WITH 8 SHARED DISPOSITIVE POWER
2,844,478
- --------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
2,844,478
- --------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
|_|
- --------------------------------------------------------------------------------
11 PERCENTAGE CLASS REPRESENTED BY AMOUNT IN ROW 9
32.1%
- --------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
IN
- --------------------------------------------------------------------------------
*SEE INSTRUCTIONS BEFORE FILLING OUT!
<PAGE>
Page 12 of 16
Item 1.
(a) Name of Issuer:
Virus Research Institute, Inc.
(b) Address of Issuer's Principal Executive Offices:
61 Moulton Street
Cambridge, Massachusetts 02138
Item 2.
(a) Name of Person Filing:
HealthCare Ventures II, L.P. ("HCV II"), HealthCare Partners
II, L.P. ("HCP II"), HealthCare Ventures III, L.P. ("HCV
III"), HealthCare Partners III, L.P. ("HCP III"), HealthCare
Ventures IV, L.P. ("HCV IV"), HealthCare Partners IV, L.P.
("HCP IV"), Dr. Cavanaugh and Messrs. Werner, Littlechild, and
Crouse. See attached Exhibit A which is a copy of their
agreement in writing to file this statement on behalf of each
of them.1
(b) Address of Principal Business Office or, if none, Residence:
The business address for HCV II, HCP II, HCV III, HCP III, HCV
IV, HCP IV, Dr. Cavanaugh and Messrs. Werner and Crouse is
Twin Towers at Metro Park, 379 Thornall Street, Edison, New
Jersey 08837. The business address for Mr. Littlechild is One
Kendall Square, Building 300, Cambridge, Massachusetts 02139.
(c) Citizenship:
HCV II, HCP II, HCV III, HCP III, HCV IV and HCP IV are
limited partnerships organized under the laws of the State of
Delaware. Dr. Cavanaugh and Messrs. Werner, Littlechild and
Crouse are each United States citizens.
(d) Title of Class of Securities:
Common Stock, par value $.001 ("Shares").
- --------
1 Dr. Cavanaugh and Messrs. Werner, Littlechild and Crouse are
general partners of each of HCP II, HCP III and HCP IV, which
are the general partner of each of HCV II, HCV III and HCV IV,
respectively the record holder of Issuer's securities.
<PAGE>
Page 13 of 16
(e) CUSIP Number:
927920108
Item 3. If this statement is filed pursuant to Rule 13d-1(b), or
13d-2(b), check whether the person filing is a:
Inapplicable.
Item 4. Ownership.
(a) Amount Beneficially Owned:
As of December 31, 1996: HCV II and HCP II beneficially owned
1,324,975 Shares of Issuer's Common Stock; HCV III and HCP III
beneficially owned 1,174,575 Shares of Issuer's Securities,
consisting of 1,131,595 Shares of Issuer's Common Stock and
immediately exercisable warrants to purchase 42,980 Shares of
Issuer's Common Stock; HCV IV and HCP IV beneficially owned
344,928 Shares of Issuer's Securities, consisting of 332,306
Shares of Issuer's Common Stock and immediately exercisable
warrants to purchase 12,622 Shares of Issuer's Common Stock;
and Dr. Cavanaugh and Messrs. Werner, Littlechild and Crouse
beneficially owned 2,844,478 Shares of Issuer's Securities,
consisting of 2,788,876 Shares of Issuer's Common Stock and
immediately exercisable warrants to purchase 55,602 Shares of
Issuer's Common Stock.
(b) Percent of Class:
As of December 31, 1996: the 1,131,595 Shares of Issuer's
Securities beneficially owned by HCV II and HCP II constitute
15% of Issuer's Shares outstanding; the 1,174,575 Shares of
Issuer's Securities beneficially owned by HCV III and HCP III
constitute 13.3% of the Issuer's Shares outstanding; the
344,928 Shares of Issuer's Securities beneficially owned by
HCV IV and HCP IV consisted 4.0% of Issuer's Shares
outstanding and the 2,844,478 Shares of Issuer's Securities
beneficially owned by Dr. Cavanaugh and Messrs. Werner,
Littlechild and Crouse constitute 32.1% of Issuer's Shares
outstanding.
(c) Number of shares as to which such person has:
(i) sole power to vote or to direct the vote:
Inapplicable
(ii) shared power to vote or to direct the vote: HCV II,
HCP II, Dr. Cavanaugh and Messrs. Werner,
Littlechild, and Crouse share the power to vote or
direct the vote of those shares owned by HCV II.
<PAGE>
Page 14 of 16
HCV III, HCP III, Dr. Cavanaugh and Messrs. Werner,
Littlechild, and Crouse share the power to vote or
direct the vote of those shares owned by HCV III.
HCV IV, HCP IV, Dr. Cavanaugh and Messrs. Werner,
Littlechild, and Crouse share the power to vote or
direct the vote of those shares owned by HCV IV.
(iii) sole power to dispose or to direct the disposition
of:
Inapplicable
(iv) shared power to dispose of or to direct the
disposition of: HCV II, HCP II, Dr. Cavanaugh and
Messrs. Werner, Littlechild and Crouse share the
power to dispose of or direct the disposition of
those shares owned by HCV II.
HCV III, HCP III, Dr. Cavanaugh and Messrs. Werner,
Littlechild and Crouse share the power to dispose of
or direct the disposition of those shares owned by
HCV III.
HCV IV, HCP IV, Dr. Cavanaugh and Messrs. Werner,
Littlechild and Crouse share the power to dispose of
or direct the disposition of those shares owned by
HCV IV.
Item 5. Ownership of Five Percent or less of a Class:
Inapplicable.
Item 6. Ownership of More than Five Percent on Behalf of Another
Person:
Inapplicable.
Item 7. Identification and Classification of the Subsidiary Which
Acquired the Security Being Reported on by the Parent Holding
Company:
Inapplicable.
Item 8. Identification and Classification of Members of the Group:
Inapplicable.
Item 9. Notice of Dissolution of Group:
Inapplicable.
Item 10. Certification:
Inapplicable.
<PAGE>
Page 15 of 16
SIGNATURES
After reasonable inquiry and to the best of my knowledge and
belief, I certify that the information set forth in this statement is true,
complete and correct.
<TABLE>
<S> <C>
Dated: February 13, 1997 HealthCare Ventures II, L.P.,
Edison, New Jersey by its General Partner, HealthCare Partners II, L.P.
By: /s/ Jeffrey Steinberg
--------------------------------
Administrative Partner
Dated: February 13, 1997 HealthCare Partners II, L.P.
Edison, New Jersey
By: /s/ Jeffrey Steinberg
--------------------------------
Administrative Partner
Dated: February 13, 1997 HealthCare Ventures III, L.P.,
Edison, New Jersey by its General Partner, HealthCare Partners III, L.P.
By: /s/ Jeffrey Steinberg
--------------------------------
Administrative Partner
Dated: February 13, 1997 HealthCare Partners III, L.P.
Edison, New Jersey
By: /s/ Jeffrey Steinberg
--------------------------------
Administrative Partner
Dated: February 13, 1997 HealthCare Ventures IV, L.P.,
Edison, New Jersey by its General Partner, HealthCare Partners IV, L.P.
By: /s/ Jeffrey Steinberg
--------------------------------
Administrative Partner
Dated: February 13, 1997 HealthCare Partners IV, L.P.
Edison, New Jersey
By: /s/ Jeffrey Steinberg
--------------------------------
Administrative Partner
Dated: February 13, 1997 By: /s/ Jeffrey Steinberg as Attorney-in-Fact
--------------------------------
Edison, New Jersey James H. Cavanaugh, Ph.D.
Dated: February 13, 1997 By: /s/ Jeffrey Steinberg as Attorney-in-Fact
--------------------------------
Edison, New Jersey Harold R. Werner
Dated: February 13, 1997 By: /s/ Jeffrey Steinberg as Attorney-in-Fact
--------------------------------
Cambridge, Massachusetts John W. Littlechild
Dated: February 13, 1997 By: /s/ Jeffrey Steinberg as Attorney-in-Fact
--------------------------------
Edison, New Jersey William Crouse
</TABLE>
<PAGE>
Page 16 of 16
EXHIBIT A
AGREEMENT
JOINT FILING OF SCHEDULE 13G
The undersigned hereby agree to jointly prepare and file with
regulatory authorities a Schedule 13G and any future amendments thereto
reporting each of the undersigned's ownership of securities of Virus Research
Institute, Inc. and hereby affirm that such Schedule 13G is being filed on
behalf of each of the undersigned.
<TABLE>
<S> <C>
Dated: February 13, 1997 HealthCare Ventures II, L.P.,
Edison, New Jersey by its General Partner, HealthCare Partners II, L.P.
By: /s/ Jeffrey Steinberg
--------------------------------
Administrative Partner
Dated: February 13, 1997 HealthCare Partners II, L.P.
Edison, New Jersey
By: /s/ Jeffrey Steinberg
--------------------------------
Administrative Partner
Dated: February 13, 1997 HealthCare Ventures III, L.P.,
Edison, New Jersey by its General Partner, HealthCare Partners III, L.P.
By: /s/ Jeffrey Steinberg
--------------------------------
Administrative Partner
Dated: February 13, 1997 HealthCare Partners III, L.P.
Edison, New Jersey
By: /s/ Jeffrey Steinberg
--------------------------------
Administrative Partner
Dated: February 13, 1997 HealthCare Ventures IV, L.P.,
Edison, New Jersey by its General Partner, HealthCare Partners IV, L.P.
By: /s/ Jeffrey Steinberg
--------------------------------
Administrative Partner
Dated: February 13, 1997 HealthCare Partners IV, L.P.
Edison, New Jersey
By: /s/ Jeffrey Steinberg
--------------------------------
Administrative Partner
Dated: February 13, 1997 By: /s/ Jeffrey Steinberg as Attorney-in-Fact
--------------------------------
Edison, New Jersey James H. Cavanaugh, Ph.D.
Dated: February 13, 1997 By: /s/ Jeffrey Steinberg as Attorney-in-Fact
--------------------------------
Edison, New Jersey Harold R. Werner
Dated: February 13, 1997 By: /s/ Jeffrey Steinberg as Attorney-in-Fact
--------------------------------
Cambridge, Massachusetts John W. Littlechild
Dated: February 13, 1997 By: /s/ Jeffrey Steinberg as Attorney-in-Fact
--------------------------------
Edison, New Jersey William Crouse
</TABLE>
