HEALTHCARE VENTURES II LP
SC 13G, 1997-02-14
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<PAGE>
 


                      SECURITIES AND EXCHANGE COMMISSION
                            Washington, D.C. 20549


                                 SCHEDULE 13G


                   Under the Securities Exchange Act of 1934
                             (Amendment No.  )*


                           BIOTRANSPLANT INCORPORATED
       -----------------------------------------------------------------
                               (Name of Issuer)


                           Common Stock $.01 par value
       -----------------------------------------------------------------
                        (Title of Class of Securities)


                                    09066Y107
       -----------------------------------------------------------------
                                 (CUSIP Number)


       Check the following box if a fee is being paid with this statement
       [X]. (A fee is not required only if the reporting person: (1) has
       a previous statement on file reporting beneficial ownership of
       more than five percent of the class of securities described in
       Item 1; and (2) has filed no amendment subsequent thereto
       reporting beneficial ownership of five percent or less of such
       class.) (See Rule 13d-7.)


       *The remainder of this cover page shall be filled out for a
       reporting person's initial filing on this form with respect to
       the subject class of securities, and for any subsequent amendment
       containing information which would alter the disclosures provided
       in a prior cover page.


       The information required in the remainder of this cover page
       shall not be deemed to be "filed" for the purpose of Section 18
       of the Securities Exchange Act of 1934 ("Act") or otherwise
       subject to the liabilities of that section of the Act but shall
       be subject to all other provisions of the Act (however, see the
       Notes).




                        (Continued on following page(s))
                               Page 1 of 17 pages
                                    --   --
<PAGE> 
       CUSIP No.  09066Y107        13G               Page  2  of  17  pages
                 ------------                            -----  -----
       -------------------------------------------------------------------
       1.   NAME OF REPORTING PERSON
            S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

            HealthCare Ventures II, L.P.
           
       -------------------------------------------------------------------
       2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*    (a) [ ]
                                                                 (b) [ ]
       -------------------------------------------------------------------
       3.   SEC USE ONLY

       -------------------------------------------------------------------
       4.   CITIZENSHIP OR PLACE OF ORGANIZATION

            Delaware
       -------------------------------------------------------------------
                           5.   SOLE VOTING POWER
             
                                
                           -----------------------------------------------
        NUMBER OF          6.   SHARED VOTING POWER
          SHARES
       BENEFICIALLY             1,570,886
         OWNED BY          -----------------------------------------------
           EACH            7.   SOLE DISPOSITIVE POWER
        REPORTING       
          PERSON                
           WITH            -----------------------------------------------
                           8.   SHARED DISPOSITIVE POWER

                                1,570,886
       -------------------------------------------------------------------
       9.  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

            1,570,886
       -------------------------------------------------------------------
       10. CHECK  BOX IF THE AGGREGATE  AMOUNT  IN  ROW  (9)  EXCLUDES
           CERTAIN SHARES*    [ ]

                                       
       -------------------------------------------------------------------
       11. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

             18.2%
       -------------------------------------------------------------------
       12. TYPE OF REPORTING PERSON*

           PN
       -------------------------------------------------------------------
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!
<PAGE>

       CUSIP No.    09066Y107      13G               Page  3  of  17  pages
                 ------------                            -----  -----
       -------------------------------------------------------------------
       1.   NAME OF REPORTING PERSON
            S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

            HealthCare Partners II, L.P.
           
       -------------------------------------------------------------------
       2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*    (a) [ ]
                                                                 (b) [ ]
       -------------------------------------------------------------------
       3.   SEC USE ONLY

       -------------------------------------------------------------------
       4.   CITIZENSHIP OR PLACE OF ORGANIZATION

            Delaware
       -------------------------------------------------------------------
                           5.   SOLE VOTING POWER
             
                                
                           -----------------------------------------------
        NUMBER OF          6.   SHARED VOTING POWER
          SHARES
       BENEFICIALLY             1,570,886
         OWNED BY          -----------------------------------------------
           EACH            7.   SOLE DISPOSITIVE POWER
        REPORTING       
          PERSON                
           WITH            -----------------------------------------------
                           8.   SHARED DISPOSITIVE POWER

                                1,570,886
       -------------------------------------------------------------------
       9.  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

            1,570,886
       -------------------------------------------------------------------
       10. CHECK  BOX IF THE AGGREGATE  AMOUNT  IN  ROW  (9)  EXCLUDES
           CERTAIN SHARES*    [ ]

                                       
       -------------------------------------------------------------------
       11. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

             18.2%
       -------------------------------------------------------------------
       12. TYPE OF REPORTING PERSON*

           PN
       -------------------------------------------------------------------
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!
<PAGE>

       CUSIP No.   09066Y107        13G               Page  4  of  17  pages
                 ------------                            -----  -----
       -------------------------------------------------------------------
       1.   NAME OF REPORTING PERSON
            S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

            HealthCare Ventures III, L.P.
           
       -------------------------------------------------------------------
       2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*    (a) [ ]
                                                                 (b) [ ]
       -------------------------------------------------------------------
       3.   SEC USE ONLY

       -------------------------------------------------------------------
       4.   CITIZENSHIP OR PLACE OF ORGANIZATION

            Delaware
       -------------------------------------------------------------------
                           5.   SOLE VOTING POWER
             
                                
                           -----------------------------------------------
        NUMBER OF          6.   SHARED VOTING POWER
          SHARES
       BENEFICIALLY             874,539
         OWNED BY          -----------------------------------------------
           EACH            7.   SOLE DISPOSITIVE POWER
        REPORTING       
          PERSON                
           WITH            -----------------------------------------------
                           8.   SHARED DISPOSITIVE POWER

                                874,539
       -------------------------------------------------------------------
       9.  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

            874,539
       -------------------------------------------------------------------
       10. CHECK  BOX IF THE AGGREGATE  AMOUNT  IN  ROW  (9)  EXCLUDES
           CERTAIN SHARES*    [ ]

                                       
       -------------------------------------------------------------------
       11. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

           10.1%
       -------------------------------------------------------------------
       12. TYPE OF REPORTING PERSON*

           PN
       -------------------------------------------------------------------
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!
<PAGE>


       CUSIP No.  09066Y107        13G               Page  5  of  17  pages
                 ------------                            -----  -----
       -------------------------------------------------------------------
       1.   NAME OF REPORTING PERSON
            S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

            HealthCare Partners III, L.P.
           
       -------------------------------------------------------------------
       2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*    (a) [ ]
                                                                 (b) [ ]
       -------------------------------------------------------------------
       3.   SEC USE ONLY

       -------------------------------------------------------------------
       4.   CITIZENSHIP OR PLACE OF ORGANIZATION

            Delaware
       -------------------------------------------------------------------
                           5.   SOLE VOTING POWER
             
                               
                           -----------------------------------------------
        NUMBER OF          6.   SHARED VOTING POWER
          SHARES
       BENEFICIALLY             874,539
         OWNED BY          -----------------------------------------------
           EACH            7.   SOLE DISPOSITIVE POWER
        REPORTING       
          PERSON                
           WITH            -----------------------------------------------
                           8.   SHARED DISPOSITIVE POWER

                                874,539
       -------------------------------------------------------------------
       9.  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           874,539
       -------------------------------------------------------------------
       10. CHECK  BOX IF THE AGGREGATE  AMOUNT  IN  ROW  (9)  EXCLUDES
           CERTAIN SHARES*    [ ]

                                       
       -------------------------------------------------------------------
       11. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

            10.1%
       -------------------------------------------------------------------
       12. TYPE OF REPORTING PERSON*

           PN
       -------------------------------------------------------------------
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!
<PAGE>


       CUSIP No.   09066Y107        13G               Page  6  of  17  pages
                 ------------                            -----  -----
       -------------------------------------------------------------------
       1.   NAME OF REPORTING PERSON
            S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

            HealthCare Ventures IV, L.P.
           
       -------------------------------------------------------------------
       2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*    (a) [ ]
                                                                 (b) [ ]
       -------------------------------------------------------------------
       3.   SEC USE ONLY

       -------------------------------------------------------------------
       4.   CITIZENSHIP OR PLACE OF ORGANIZATION

            Delaware
       -------------------------------------------------------------------
                           5.   SOLE VOTING POWER
             
                                
                           -----------------------------------------------
        NUMBER OF          6.   SHARED VOTING POWER
          SHARES
       BENEFICIALLY             258,075
         OWNED BY          -----------------------------------------------
           EACH            7.   SOLE DISPOSITIVE POWER
        REPORTING       
          PERSON                
           WITH            -----------------------------------------------
                           8.   SHARED DISPOSITIVE POWER

                                258,075
       -------------------------------------------------------------------
       9.  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

            258,075
       -------------------------------------------------------------------
       10. CHECK  BOX IF THE AGGREGATE  AMOUNT  IN  ROW  (9)  EXCLUDES
           CERTAIN SHARES*    [ ]

                                       
       -------------------------------------------------------------------
       11. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

           3.0%
       -------------------------------------------------------------------
       12. TYPE OF REPORTING PERSON*

           PN
       -------------------------------------------------------------------
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!
<PAGE>


       CUSIP No.  09066Y107       13G               Page  7  of  17  pages
                 ------------                            -----  -----
       -------------------------------------------------------------------
       1.   NAME OF REPORTING PERSON
            S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

            HealthCare Partners IV, L.P.
           
       -------------------------------------------------------------------
       2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*    (a) [ ]
                                                                 (b) [ ]
       -------------------------------------------------------------------
       3.   SEC USE ONLY

       -------------------------------------------------------------------
       4.   CITIZENSHIP OR PLACE OF ORGANIZATION

            Delaware
       -------------------------------------------------------------------
                           5.   SOLE VOTING POWER
             
                               
                           -----------------------------------------------
        NUMBER OF          6.   SHARED VOTING POWER
          SHARES
       BENEFICIALLY             258,075
         OWNED BY          -----------------------------------------------
           EACH            7.   SOLE DISPOSITIVE POWER
        REPORTING       
          PERSON                
           WITH            -----------------------------------------------
                           8.   SHARED DISPOSITIVE POWER

                                258,075
       -------------------------------------------------------------------
       9.  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

          258,075
       -------------------------------------------------------------------
       10. CHECK  BOX IF THE AGGREGATE  AMOUNT  IN  ROW  (9)  EXCLUDES
           CERTAIN SHARES*    [ ]

                                       
       -------------------------------------------------------------------
       11. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

            3.0%
       -------------------------------------------------------------------
       12. TYPE OF REPORTING PERSON*

           PN
       -------------------------------------------------------------------
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!
<PAGE>

       CUSIP No.   09066Y107         13G             Page 8  of  17  pages
                 ------------                            -----  -----
       -------------------------------------------------------------------
       1.   NAME OF REPORTING PERSON
            S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

            James H. Cavanaugh, Ph.D.
           
       -------------------------------------------------------------------
       2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*    (a) [ ]
                                                                 (b) [ ]
       -------------------------------------------------------------------
       3.   SEC USE ONLY

       -------------------------------------------------------------------
       4.   CITIZENSHIP OR PLACE OF ORGANIZATION

            United States
       -------------------------------------------------------------------
                           5.   SOLE VOTING POWER
             
                                
                           -----------------------------------------------
        NUMBER OF          6.   SHARED VOTING POWER
          SHARES
       BENEFICIALLY             2,703,500
         OWNED BY          -----------------------------------------------
           EACH            7.   SOLE DISPOSITIVE POWER
        REPORTING       
          PERSON                
           WITH            -----------------------------------------------
                           8.   SHARED DISPOSITIVE POWER

                                2,703,500
       -------------------------------------------------------------------
       9.  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

            2,703,500
       -------------------------------------------------------------------
       10. CHECK  BOX IF THE AGGREGATE  AMOUNT  IN  ROW  (9)  EXCLUDES
           CERTAIN SHARES*    [ ]

                                       
       -------------------------------------------------------------------
       11. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

            30.9%
       -------------------------------------------------------------------
       12. TYPE OF REPORTING PERSON*

           IN
       -------------------------------------------------------------------
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!
<PAGE>


       CUSIP No.   09066Y107        13G               Page  9  of  17  pages
                 ------------                            -----  -----
       -------------------------------------------------------------------
       1.   NAME OF REPORTING PERSON
            S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

            Harold R. Werner
           
       -------------------------------------------------------------------
       2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*    (a) [ ]
                                                                 (b) [ ]
       -------------------------------------------------------------------
       3.   SEC USE ONLY

       -------------------------------------------------------------------
       4.   CITIZENSHIP OR PLACE OF ORGANIZATION

            United States
       -------------------------------------------------------------------
                           5.   SOLE VOTING POWER
             
                               
                           -----------------------------------------------
        NUMBER OF          6.   SHARED VOTING POWER
          SHARES
       BENEFICIALLY             2,703,500
         OWNED BY          -----------------------------------------------
           EACH            7.   SOLE DISPOSITIVE POWER
        REPORTING       
          PERSON                 
           WITH            -----------------------------------------------
                           8.   SHARED DISPOSITIVE POWER

                                 2,703,500
       -------------------------------------------------------------------
       9.  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

             2,703,500
       -------------------------------------------------------------------
       10. CHECK  BOX IF THE AGGREGATE  AMOUNT  IN  ROW  (9)  EXCLUDES
           CERTAIN SHARES*    [ ]

                                       
       -------------------------------------------------------------------
       11. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

             30.9%
       -------------------------------------------------------------------
       12. TYPE OF REPORTING PERSON*

           IN
       -------------------------------------------------------------------
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!
<PAGE>


       CUSIP No.   09066Y107        13G               Page 10  of  17  pages
                 ------------                            -----  -----
       -------------------------------------------------------------------
       1.   NAME OF REPORTING PERSON
            S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

            William Crouse
           
       -------------------------------------------------------------------
       2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*    (a) [ ]
                                                                 (b) [ ]
       -------------------------------------------------------------------
       3.   SEC USE ONLY

       -------------------------------------------------------------------
       4.   CITIZENSHIP OR PLACE OF ORGANIZATION

            United States
       -------------------------------------------------------------------
                           5.   SOLE VOTING POWER
             
                               
                           -----------------------------------------------
        NUMBER OF          6.   SHARED VOTING POWER
          SHARES
       BENEFICIALLY             2,703,500
         OWNED BY          -----------------------------------------------
           EACH            7.   SOLE DISPOSITIVE POWER
        REPORTING       
          PERSON                 
           WITH            -----------------------------------------------
                           8.   SHARED DISPOSITIVE POWER

                                 2,703,500
       -------------------------------------------------------------------
       9.  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

             2,703,500
       -------------------------------------------------------------------
       10. CHECK  BOX IF THE AGGREGATE  AMOUNT  IN  ROW  (9)  EXCLUDES
           CERTAIN SHARES*    [ ]

                                       
       -------------------------------------------------------------------
       11. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

             30.9%
       -------------------------------------------------------------------
       12. TYPE OF REPORTING PERSON*

           IN
       -------------------------------------------------------------------
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!


<PAGE>


       CUSIP No.   09066Y107        13G               Page 11  of  17  pages
                 ------------                            -----  -----

       -------------------------------------------------------------------
       1.   NAME OF REPORTING PERSON
            S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

             John W. Littlechild
           
       -------------------------------------------------------------------
       2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*    (a) [ ]
                                                                 (b) [ ]
       -------------------------------------------------------------------
       3.   SEC USE ONLY

       -------------------------------------------------------------------
       4.   CITIZENSHIP OR PLACE OF ORGANIZATION

            United States
       -------------------------------------------------------------------
                           5.   SOLE VOTING POWER
             
                                
                           -----------------------------------------------
        NUMBER OF          6.   SHARED VOTING POWER
          SHARES
       BENEFICIALLY             2,703,500
         OWNED BY          -----------------------------------------------
           EACH            7.   SOLE DISPOSITIVE POWER
        REPORTING       
          PERSON                
           WITH            -----------------------------------------------
                           8.   SHARED DISPOSITIVE POWER

                                2,703,500
       -------------------------------------------------------------------
       9.  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

            2,703,500
       -------------------------------------------------------------------
       10. CHECK  BOX IF THE AGGREGATE  AMOUNT  IN  ROW  (9)  EXCLUDES
           CERTAIN SHARES*    [ ]

                                       
       -------------------------------------------------------------------
       11. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

             30.9%
       -------------------------------------------------------------------
       12. TYPE OF REPORTING PERSON*

           IN
       -------------------------------------------------------------------
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!
<PAGE>


                                                           Page 12 of 17 Pages

Item 1.

         (a)      Name of Issuer:

                  BioTransplant Incorporated

         (b)      Address of Issuer's Principal Executive Offices:

                  Charlestown Navy Yard, Building 75, Third Avenue
                  Charlestown, Massachusetts 02129

Item 2.

         (a)      Name of Person Filing:

                  HealthCare Ventures II, L.P. ("HCV II"), HealthCare Partners
                  II, L.P. ("HCP II"), HealthCare Ventures III, L.P. ("HCV
                  III"), HealthCare Partners III, L.P. ("HCP III"), HealthCare
                  Ventures IV, L.P. ("HCV IV"), HealthCare Partners IV, L.P.
                  ("HCP IV"), Dr. Cavanaugh and Messrs. Werner, Littlechild, and
                  Crouse. See attached Exhibit A which is a copy of their
                  agreement in writing to file this statement on behalf of each
                  of them.(1)

         (b)      Address of Principal Business Office or, if none, Residence:

                  The business address for HCV II, HCP II, HCV III, HCP III, HCV
                  IV, HCP IV and Dr. Cavanaugh and Messrs. Werner and Crouse is
                  Twin Towers at Metro Park, 379 Thornall Street, Edison, New
                  Jersey 08837. The business address for Mr. Littlechild is One
                  Kendall Square, Building 300, Cambridge, Massachusetts 02139.

         (c)      Citizenship:

                  HCV II, HCP II, HCV III, HCP III, HCV IV and HCP IV are
                  limited partnerships organized under the laws of the State of
                  Delaware. Dr. Cavanaugh and Messrs. Werner, Littlechild and
                  Crouse are each United States citizens.

         (d)      Title of Class of Securities:

                  Common Stock, par value $.01 ("Shares").

 --------
 (1)      Dr. Cavanaugh and Messrs. Werner, Littlechild and Crouse are
        general partners of each of HCP II, HCP III and HCP IV, which
        are the general partner of each of HCV II, HCV III and HCV IV,
        respectively the record holder of Issuer's securities.

<PAGE>


                                                             Page 13 of 17 Pages

         (e)      CUSIP Number:

                  09066Y107

Item 3.           If this statement is filed pursuant to Rule 13d-1(b), or
                  13d-2(b), check whether the person filing is a:

                  Inapplicable.

Item 4.           Ownership.

         (a)      Amount Beneficially Owned:

                  As of December 31, 1996: HCV II and HCP II beneficially owned
                  1,570,886 Shares of Issuer's Securities, consisting of
                  1,492,009 Shares of Issuer's Common Stock and immediately
                  exercisable warrants to purchase 42,980 Shares of Issuers
                  Common Stock. HCV III and HCP III beneficially owned 874,539
                  Shares of Issuer's Securities, consisting of 774,834 Shares of
                  Issuer's Common Stock and immediately exercisable warrants to
                  purchase 99,705 Shares of Issuer's Common Stock; HCV IV and
                  HCP IV beneficially owned 258,075 Shares of Issuer's
                  Securities, consisting of 228,504 Shares of Issuer's Common
                  Stock and immediately exercisable warrants to purchase 29,571
                  Shares of Issuer's Common Stock; and Dr. Cavanaugh and Messrs.
                  Werner, Littlechild and Crouse beneficially owned 2,703,500
                  Shares of Issuer's Securities, consisting of 2,495,347 Shares
                  of Common Stock and immediately exercisable warrants to
                  purchase 208,153 Shares of Issuer's Common Stock.

         (b)      Percent of Class:

                  As of December 31, 1996: the 1,570,886 Shares of Issuer's
                  Securities beneficially owned by HCV II and HCP II constitute
                  18.2% of Issuer's Shares outstanding; the 874,539 Shares of
                  Issuer's Securities beneficially owned by HCV III and HCP III
                  constitute 10.1% of the Issuer's Shares outstanding; the
                  258,075 Shares of Issuer's Securities beneficially owned by
                  HCV IV and HCP IV constitute 3.0% of Issuer's Shares
                  outstanding; and the 2,703,500 Shares of Issuer's Securities
                  beneficially owned by Dr. Cavanaugh and Messrs. Werner,
                  Littlechild and Crouse constitute 30.9% of Issuer's Shares
                  outstanding.

         (c)      Number of shares as to which such person has:

                  (i)      sole power to vote or to direct the vote:

                           Inapplicable


<PAGE>


                                                             Page 14 of 17 Pages

                  (ii)     shared power to vote or to direct the vote: HCV II,
                           HCP II, Dr. Cavanaugh and Messrs. Werner,
                           Littlechild, and Crouse share the power to vote or
                           direct the vote of those Shares owned by HCV II.

                           HCV III, HCP III, Dr. Cavanaugh and Messrs. Werner,
                           Littlechild, and Crouse share the power to vote or
                           direct the vote of those Shares owned by HCV III.

                           HCV IV, HCP IV, Dr. Cavanaugh and Messrs. Werner,
                           Littlechild, and Crouse share the power to vote or
                           direct the vote of those Shares owned by HCV IV.

                  (iii)    sole power to dispose or to direct the disposition
                           of:

                           Inapplicable

                  (iv)     shared power to dispose of or to direct the
                           disposition of: HCV II, HCP II, Dr. Cavanaugh and
                           Messrs. Werner, Littlechild and Crouse share the
                           power to dispose of or direct the disposition of
                           those Shares owned by HCV II.

                           HCV III, HCP III, Dr. Cavanaugh and Messrs. Werner,
                           Littlechild and Crouse share the power to dispose of
                           or direct the disposition of those Shares owned by
                           HCV III.

                           HCV IV, HCP IV, Dr. Cavanaugh and Messrs. Werner,
                           Littlechild and Crouse share the power to dispose of
                           or direct the disposition of those Shares owned by
                           HCV IV.

Item 5.           Ownership of Five Percent or less of a Class:

                  Inapplicable.

Item 6.           Ownership of More than Five Percent on Behalf of Another
                  Person:

                  Inapplicable.

Item 7.           Identification and Classification of the Subsidiary Which
                  Acquired the Security Being Reported on by the Parent Holding
                  Company:

                  Inapplicable.

Item 8.           Identification and Classification of Members of the Group:

                  Inapplicable.


                                                                        

<PAGE>


                                                             Page 15 of 17 Pages

Item 9.           Notice of Dissolution of Group:

                  Inapplicable.

Item 10.          Certification:

                  Inapplicable.



                                                                         

<PAGE>


                                                             Page 16 of 17 Pages

                                   SIGNATURES

                  After reasonable inquiry and to the best of my knowledge and
belief, I certify that the information set forth in this statement is true,
complete and correct.
<TABLE>

<S>                                                 <C>                                                    
Dated:  February 13, 1997                        HealthCare Ventures II, L.P.,
             Edison, New Jersey                  by its General Partner, HealthCare Partners II, L.P.

                                                 By:   /s/ Jeffrey Steinberg
                                                     -------------------------------------------
                                                           Administrative Partner

Dated:  February 13, 1997                        HealthCare Partners II, L.P.
             Edison, New Jersey
                                                 By:   /s/ Jeffrey Steinberg
                                                     -------------------------------------------
                                                           Administrative Partner

Dated:  February 13, 1997                        HealthCare Ventures III, L.P.,
             Edison, New Jersey                  by its General Partner, HealthCare Partners III, L.P.

                                                 By:   /s/ Jeffrey Steinberg
                                                     -------------------------------------------
                                                           Administrative Partner

Dated:  February 13, 1997                        HealthCare Partners III, L.P.
             Edison, New Jersey
                                                 By:   /s/ Jeffrey Steinberg
                                                     -------------------------------------------
                                                           Administrative Partner

Dated:  February 13, 1997                        HealthCare Ventures IV, L.P.,
             Edison, New Jersey                  by its General Partner, HealthCare Partners IV, L.P.

                                                 By:   /s/ Jeffrey Steinberg
                                                     ------------------------------------------
                                                           Administrative Partner

Dated:  February 13, 1997                        HealthCare Partners IV, L.P.
             Edison, New Jersey
                                                 By:   /s/ Jeffrey Steinberg 
                                                     -------------------------------------------
                                                           Administrative Partner

Dated:  February 13, 1997                        By:   /s/ Jeffrey Steinberg as Attorney-in-Fact
              Edison, New Jersey                     -------------------------------------------
                                                           James H. Cavanaugh, Ph.D.

Dated:  February 13, 1997                        By:   /s/ Jeffrey Steinberg as Attorney-in-Fact
               Edison, New Jersey                    -------------------------------------------
                                                           Harold R. Werner

Dated:  February 13, 1997                        By:   /s/ Jeffrey Steinberg as Attorney-in-Fact
               Cambridge, Massachusetts               ------------------------------------------
                                                           John W. Littlechild

Dated:  February 13, 1997                        By:   /s/ Jeffrey Steinberg as Attorney-in-Fact
                Edison, New Jersey                    ------------------------------------------
                                                           William Crouse

</TABLE>

<PAGE>


                                                             Page 17 of 17 Pages
                                    EXHIBIT A

                                    AGREEMENT

                          JOINT FILING OF SCHEDULE 13G

                  The undersigned hereby agree to jointly prepare and file with
regulatory authorities a Schedule 13G and any future amendments thereto
reporting each of the undersigned's ownership of securities of BioTransplant
Incorporated and hereby affirm that such Schedule 13G is being filed on behalf
of each of the undersigned.
<TABLE>

<S>                                                 <C>                                                    
Dated:  February 13, 1997                        HealthCare Ventures II, L.P.,
             Edison, New Jersey                  by its General Partner, HealthCare Partners II, L.P.

                                                 By:   /s/ Jeffrey Steinberg
                                                     -------------------------------------------
                                                           Administrative Partner

Dated:  February 13, 1997                        HealthCare Partners II, L.P.
             Edison, New Jersey
                                                 By:   /s/ Jeffrey Steinberg
                                                     -------------------------------------------
                                                           Administrative Partner

Dated:  February 13, 1997                        HealthCare Ventures III, L.P.,
             Edison, New Jersey                  by its General Partner, HealthCare Partners III, L.P.

                                                 By:   /s/ Jeffrey Steinberg
                                                     -------------------------------------------
                                                           Administrative Partner

Dated:  February 13, 1997                        HealthCare Partners III, L.P.
             Edison, New Jersey
                                                 By:   /s/ Jeffrey Steinberg
                                                     -------------------------------------------
                                                           Administrative Partner

Dated:  February 13, 1997                        HealthCare Ventures IV, L.P.,
             Edison, New Jersey                  by its General Partner, HealthCare Partners IV, L.P.

                                                 By:   /s/ Jeffrey Steinberg
                                                     -------------------------------------------
                                                           Administrative Partner

Dated:  February 13, 1997                        HealthCare Partners IV, L.P.
             Edison, New Jersey
                                                 By:   /s/ Jeffrey Steinberg
                                                     -------------------------------------------
                                                          Administrative Partner

Dated:  February 13, 1997                        By:   /s/ Jeffrey Steinberg as Attorney-in-Fact
             Edison, New Jersey                      -------------------------------------------
                                                           James H. Cavanaugh, Ph.D.

Dated:  February 13, 1997                        By:   /s/ Jeffrey Steinberg as Attorney-in-Fact
             Edison, New Jersey                      -------------------------------------------
                                                           Harold R. Werner

Dated:  February 13, 1997                        By:   /s/ Jeffrey Steinberg as Attorney-in-Fact
             Cambridge, Massachusetts                -------------------------------------------
                                                           John W. Littlechild

Dated:  February 13, 1997                        By:   /s/ Jeffrey Steinberg as Attorney-in-Fact
              Edison, New Jersey                     -------------------------------------------
                                                           William Crouse
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