HEALTHCARE VENTURES II LP
SC 13D/A, 1998-02-13
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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13D


                    Under the Securities Exchange Act of 1934
                               (Amendment No. 2 )*
                                             ---

                                  Diacrin, Inc.
- --------------------------------------------------------------------------------
                                (Name of Issuer)


                           Common Stock, .01 par value
- --------------------------------------------------------------------------------
                         (Title of Class of Securities)


                                    25243N103
- --------------------------------------------------------------------------------
                                 (CUSIP Number)


           Allison Newman, Esq., Bachner, Tally, Polevoy & Misher LLP
           380 Madison Avenue, New York, New York 10017 (212) 687-7000
- --------------------------------------------------------------------------------
                  (Name, Address and Telephone Number of Person
               Authorized to Receive Notices and Communications)


                                     1/1/98
- --------------------------------------------------------------------------------
             (Date of Event which Requires Filing of this Statement)

If the filing person has previously filed a statement on Schedule 13G to report
the acquisition which is the subject of this Schedule 13D, and is filing this
schedule because of Rule 13d-1(b)(3) or (4), check the following box [ ].

Note: Six copies of this statement, including all exhibits, should be filed with
the Commission. See Rule 13d-1(a) for other parties to whom copies are to be
sent.


                        (Continued on following page(s))

                               Page 1 of 21 Pages

                      The Exhibit Index appears on page 19.

<PAGE>
______________________                                       ___________________

CUSIP No.  25243N103                  13D                    Page 2 of 21 Pages
          -----------                                            ---  ----
______________________                                       __________________
       |
    1  |    NAME OF REPORTING PERSON 
       |    S.S OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON 
       |
       |         HealthCare Ventures II, L.P.
_______|______________________________________________________________________
       |
    2  |    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*    (a)  [ ] 
       |                                                         (b)  [ ] 
_______|_______________________________________________________________________
       |
    3  |    SEC USE ONLY
_______|_______________________________________________________________________
       |
    4  |    SOURCE OF FUNDS*
       |         N/A
_______|_______________________________________________________________________
       |
    5  |    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDING IS REQUIRED 
       |    PURSUANT TO ITEMS 2(3) OR 2(e)                             [ ]      
_______|_______________________________________________________________________
       |
    6  |    CITIZENSHIP OR PLACE OR ORGANIZATION
       |         Delaware
_______|_______________________________________________________________________
               |     |
  NUMBER OF    |  7  |   SOLE VOTING POWER
   SHARES      |     |   
BENEFICIALLY   |_____|________________________________________________________
  OWNED BY     |     |
   EACH        |  8  |   SHARED VOTING POWER                                    
 REPORTING     |     |   3,196,385 
  PERSON       |_____|________________________________________________________
   WITH        |     |
               |  9  |   SOLE DISPOSITIVE POWER
               |     |   
               |_____|________________________________________________________  
               |     |
               | 10  |   SHARED DISPOSITIVE POWER             
               |     |   3,196,385
_______________|_____|_________________________________________________________
       |
   11  |   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
       |   3,196,385
_______|_______________________________________________________________________
       |
   12  |   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
       |   CERTAIN SHARES*                                             [ ]
_______|_______________________________________________________________________
       |
   13  |   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
       |   24.1%
_______|_______________________________________________________________________
       |
   14  |   TYPE OF REPORTING PERSON
       |   PN
_______|_______________________________________________________________________
                      *SEE INSTRUCTIONS BEFORE FILLING OUT



<PAGE>
______________________                                       ___________________

CUSIP No.  25243N103                  13D                    Page 3 of 21 Pages
          -----------                                            ---  ----
______________________                                       __________________
       |
    1  |    NAME OF REPORTING PERSON 
       |    S.S OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON 
       |
       |         HealthCare Partners II, L.P.
_______|______________________________________________________________________
       |
    2  |    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*    (a)  [ ] 
       |                                                         (b)  [ ] 
_______|_______________________________________________________________________
       |
    3  |    SEC USE ONLY
_______|_______________________________________________________________________
       |
    4  |    SOURCE OF FUNDS*
       |         N/A
_______|_______________________________________________________________________
       |
    5  |    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDING IS REQUIRED 
       |    PURSUANT TO ITEMS 2(3) OR 2(e)                             [ ]      
_______|_______________________________________________________________________
       |
    6  |    CITIZENSHIP OR PLACE OR ORGANIZATION
       |         Delaware
_______|_______________________________________________________________________
               |     |
  NUMBER OF    |  7  |   SOLE VOTING POWER
   SHARES      |     |   
BENEFICIALLY   |_____|________________________________________________________
  OWNED BY     |     |
   EACH        |  8  |   SHARED VOTING POWER                                    
 REPORTING     |     |   3,196,385 
  PERSON       |_____|________________________________________________________
   WITH        |     |
               |  9  |   SOLE DISPOSITIVE POWER
               |     |   
               |_____|________________________________________________________  
               |     |
               | 10  |   SHARED DISPOSITIVE POWER             
               |     |   3,196,385
_______________|_____|_________________________________________________________
       |
   11  |   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
       |   3,196,385
_______|_______________________________________________________________________
       |
   12  |   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
       |   CERTAIN SHARES*                                             [ ]
_______|_______________________________________________________________________
       |
   13  |   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
       |   24.1%
_______|_______________________________________________________________________
       |
   14  |   TYPE OF REPORTING PERSON
       |   PN
_______|_______________________________________________________________________
                      *SEE INSTRUCTIONS BEFORE FILLING OUT

<PAGE>
______________________                                       ___________________

CUSIP No.  25243N103                  13D                    Page 4 of 21 Pages
          -----------                                            ---  ----
______________________                                       __________________
       |
    1  |    NAME OF REPORTING PERSON 
       |    S.S OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON 
       |
       |         HealthCare Ventures III, L.P.
_______|______________________________________________________________________
       |
    2  |    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*    (a)  [X] 
       |                                                         (b)  [ ] 
_______|_______________________________________________________________________
       |
    3  |    SEC USE ONLY
_______|_______________________________________________________________________
       |
    4  |    SOURCE OF FUNDS*
       |         N/A
_______|_______________________________________________________________________
       |
    5  |    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDING IS REQUIRED 
       |    PURSUANT TO ITEMS 2(3) OR 2(e)                            [ ]       
_______|_______________________________________________________________________
       |
    6  |    CITIZENSHIP OR PLACE OR ORGANIZATION
       |         Delaware
_______|_______________________________________________________________________
               |     |
  NUMBER OF    |  7  |   SOLE VOTING POWER
   SHARES      |     |   
BENEFICIALLY   |_____|________________________________________________________
  OWNED BY     |     |
   EACH        |  8  |   SHARED VOTING POWER                                    
 REPORTING     |     |   994,078
  PERSON       |_____|________________________________________________________
   WITH        |     |
               |  9  |   SOLE DISPOSITIVE POWER
               |     |   
               |_____|________________________________________________________  
               |     |
               | 10  |   SHARED DISPOSITIVE POWER             
               |     |   994,078
_______________|_____|_________________________________________________________
       |
   11  |   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
       |   994,078
_______|_______________________________________________________________________
       |
   12  |   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
       |   CERTAIN SHARES*                                             [ ]
_______|_______________________________________________________________________
       |
   13  |   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
       |   7.5%
_______|_______________________________________________________________________
       |
   14  |   TYPE OF REPORTING PERSON
       |   PN
_______|_______________________________________________________________________
                      *SEE INSTRUCTIONS BEFORE FILLING OUT


<PAGE>
______________________                                       ___________________

CUSIP No.  25243N103                  13D                    Page 5 of 21 Pages
          -----------                                            ---  ----
______________________                                       __________________
       |
    1  |    NAME OF REPORTING PERSON 
       |    S.S OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON 
       |
       |         HealthCare Partners III, L.P.
_______|______________________________________________________________________
       |
    2  |    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*    (a)  [X] 
       |                                                         (b)  [ ] 
_______|_______________________________________________________________________
       |
    3  |    SEC USE ONLY
_______|_______________________________________________________________________
       |
    4  |    SOURCE OF FUNDS*
       |         N/A
_______|_______________________________________________________________________
       |
    5  |    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDING IS REQUIRED 
       |    PURSUANT TO ITEMS 2(3) OR 2(e)                             [ ]      
_______|_______________________________________________________________________
       |
    6  |    CITIZENSHIP OR PLACE OR ORGANIZATION
       |         Delaware
_______|_______________________________________________________________________
               |     |
  NUMBER OF    |  7  |   SOLE VOTING POWER
   SHARES      |     |   
BENEFICIALLY   |_____|________________________________________________________
  OWNED BY     |     |
   EACH        |  8  |   SHARED VOTING POWER                                    
 REPORTING     |     |   994,078
  PERSON       |_____|________________________________________________________
   WITH        |     |
               |  9  |   SOLE DISPOSITIVE POWER
               |     |   
               |_____|________________________________________________________  
               |     |
               | 10  |   SHARED DISPOSITIVE POWER             
               |     |   994,078
_______________|_____|_________________________________________________________
       |
   11  |   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
       |   994,078
_______|_______________________________________________________________________
       |
   12  |   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
       |   CERTAIN SHARES*                                             [ ]
_______|_______________________________________________________________________
       |
   13  |   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
       |   7.5%
_______|_______________________________________________________________________
       |
   14  |   TYPE OF REPORTING PERSON
       |   PN
_______|_______________________________________________________________________
                      *SEE INSTRUCTIONS BEFORE FILLING OUT


<PAGE>
______________________                                       ___________________

CUSIP No.  25243N103                  13D                    Page 6 of 21 Pages
          -----------                                            ---  ----
______________________                                       __________________
       |
    1  |    NAME OF REPORTING PERSON 
       |    S.S OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON 
       |
       |         HealthCare Ventures IV, L.P.
_______|______________________________________________________________________
       |
    2  |    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*    (a)  [X] 
       |                                                         (b)  [ ] 
_______|_______________________________________________________________________
       |
    3  |    SEC USE ONLY
_______|_______________________________________________________________________
       |
    4  |    SOURCE OF FUNDS*
       |         N/A
_______|_______________________________________________________________________
       |
    5  |    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDING IS REQUIRED 
       |    PURSUANT TO ITEMS 2(3) OR 2(e)                             [ ]      
_______|_______________________________________________________________________
       |
    6  |    CITIZENSHIP OR PLACE OR ORGANIZATION
       |         Delaware
_______|_______________________________________________________________________
               |     |
  NUMBER OF    |  7  |   SOLE VOTING POWER
   SHARES      |     |   
BENEFICIALLY   |_____|________________________________________________________
  OWNED BY     |     |
   EACH        |  8  |   SHARED VOTING POWER                                    
 REPORTING     |     |   291,922
  PERSON       |_____|________________________________________________________
   WITH        |     |
               |  9  |   SOLE DISPOSITIVE POWER
               |     |   
               |_____|________________________________________________________  
               |     |
               | 10  |   SHARED DISPOSITIVE POWER             
               |     |   291,922
_______________|_____|_________________________________________________________
       |
   11  |   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
       |   291,922
_______|_______________________________________________________________________
       |
   12  |   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
       |   CERTAIN SHARES*                                             [ ]
_______|_______________________________________________________________________
       |
   13  |   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
       |   2.2%
_______|_______________________________________________________________________
       |
   14  |   TYPE OF REPORTING PERSON
       |   PN
_______|_______________________________________________________________________
                      *SEE INSTRUCTIONS BEFORE FILLING OUT

<PAGE>
______________________                                       ___________________

CUSIP No.  25243N103                  13D                    Page 7 of 21 Pages
          -----------                                            ---  ----
______________________                                       __________________
       |
    1  |    NAME OF REPORTING PERSON 
       |    S.S OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON 
       |
       |         HealthCare Partners IV, L.P.
_______|______________________________________________________________________
       |
    2  |    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*    (a)  [X] 
       |                                                         (b)  [ ] 
_______|_______________________________________________________________________
       |
    3  |    SEC USE ONLY
_______|_______________________________________________________________________
       |
    4  |    SOURCE OF FUNDS*
       |         N/A
_______|_______________________________________________________________________
       |
    5  |    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDING IS REQUIRED 
       |    PURSUANT TO ITEMS 2(3) OR 2(e)                             [ ]      
_______|_______________________________________________________________________
       |
    6  |    CITIZENSHIP OR PLACE OR ORGANIZATION
       |         Delaware
_______|_______________________________________________________________________
               |     |
  NUMBER OF    |  7  |   SOLE VOTING POWER
   SHARES      |     |   
BENEFICIALLY   |_____|________________________________________________________
  OWNED BY     |     |
   EACH        |  8  |   SHARED VOTING POWER                                    
 REPORTING     |     |   291,922
  PERSON       |_____|________________________________________________________
   WITH        |     |
               |  9  |   SOLE DISPOSITIVE POWER
               |     |   
               |_____|________________________________________________________  
               |     |
               | 10  |   SHARED DISPOSITIVE POWER             
               |     |   291,922
_______________|_____|_________________________________________________________
       |
   11  |   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
       |   291,922
_______|_______________________________________________________________________
       |
   12  |   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
       |   CERTAIN SHARES*                                             [ ]
_______|_______________________________________________________________________
       |
   13  |   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
       |   2.2%
_______|_______________________________________________________________________
       |
   14  |   TYPE OF REPORTING PERSON
       |   PN
_______|_______________________________________________________________________
                      *SEE INSTRUCTIONS BEFORE FILLING OUT

<PAGE>
______________________                                       ___________________

CUSIP No.  25243N103                  13D                    Page 8 of 21 Pages
          -----------                                            ---  ----
______________________                                       __________________
       |
    1  |    NAME OF REPORTING PERSON 
       |    S.S OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON 
       |
       |         James H. Cavanaugh, Ph.D.
_______|______________________________________________________________________
       |
    2  |    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*    (a)  [ ] 
       |                                                         (b)  [ ] 
_______|_______________________________________________________________________
       |
    3  |    SEC USE ONLY
_______|_______________________________________________________________________
       |
    4  |    SOURCE OF FUNDS*
       |         N/A
_______|_______________________________________________________________________
       |
    5  |    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDING IS REQUIRED 
       |    PURSUANT TO ITEMS 2(3) OR 2(e)                             [ ]      
_______|_______________________________________________________________________
       |
    6  |    CITIZENSHIP OR PLACE OR ORGANIZATION
       |         U.S.A.
_______|_______________________________________________________________________
               |     |
  NUMBER OF    |  7  |   SOLE VOTING POWER
   SHARES      |     |   
BENEFICIALLY   |_____|________________________________________________________
  OWNED BY     |     |
   EACH        |  8  |   SHARED VOTING POWER                                    
 REPORTING     |     |   4,482,385
  PERSON       |_____|________________________________________________________
   WITH        |     |
               |  9  |   SOLE DISPOSITIVE POWER
               |     |   
               |_____|________________________________________________________  
               |     |
               | 10  |   SHARED DISPOSITIVE POWER             
               |     |   4,482,385
_______________|_____|_________________________________________________________
       |
   11  |   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
       |   4,482,385
_______|_______________________________________________________________________
       |
   12  |   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
       |   CERTAIN SHARES*                                             [ ]
_______|_______________________________________________________________________
       |
   13  |   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
       |   33.8%
_______|_______________________________________________________________________
       |
   14  |   TYPE OF REPORTING PERSON
       |   IN
_______|_______________________________________________________________________
                      *SEE INSTRUCTIONS BEFORE FILLING OUT

<PAGE>
______________________                                       ___________________

CUSIP No.  25243N103                  13D                    Page 9 of 21 Pages
          -----------                                            ---  ----
______________________                                       __________________
       |
    1  |    NAME OF REPORTING PERSON 
       |    S.S OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON 
       |
       |         Harold R. Werner
_______|______________________________________________________________________
       |
    2  |    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*    (a)  [ ] 
       |                                                         (b)  [ ] 
_______|_______________________________________________________________________
       |
    3  |    SEC USE ONLY
_______|_______________________________________________________________________
       |
    4  |    SOURCE OF FUNDS*
       |         N/A
_______|_______________________________________________________________________
       |
    5  |    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDING IS REQUIRED 
       |    PURSUANT TO ITEMS 2(3) OR 2(e)                             [ ]      
_______|_______________________________________________________________________
       |
    6  |    CITIZENSHIP OR PLACE OR ORGANIZATION
       |         U.S.A.
_______|_______________________________________________________________________
               |     |
  NUMBER OF    |  7  |   SOLE VOTING POWER
   SHARES      |     |   
BENEFICIALLY   |_____|________________________________________________________
  OWNED BY     |     |
   EACH        |  8  |   SHARED VOTING POWER                                    
 REPORTING     |     |   4,482,385
  PERSON       |_____|________________________________________________________
   WITH        |     |
               |  9  |   SOLE DISPOSITIVE POWER
               |     |   
               |_____|________________________________________________________  
               |     |
               | 10  |   SHARED DISPOSITIVE POWER             
               |     |   4,482,385
_______________|_____|_________________________________________________________
       |
   11  |   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
       |   4,482,385
_______|_______________________________________________________________________
       |
   12  |   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
       |   CERTAIN SHARES*                                             [ ]
_______|_______________________________________________________________________
       |
   13  |   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
       |   33.8%
_______|_______________________________________________________________________
       |
   14  |   TYPE OF REPORTING PERSON
       |   IN
_______|_______________________________________________________________________
                      *SEE INSTRUCTIONS BEFORE FILLING OUT

<PAGE>
______________________                                       ___________________

CUSIP No.  25243N103                  13D                    Page 10 of 21 Pages
          -----------                                            ----  ----
______________________                                       __________________
       |
    1  |    NAME OF REPORTING PERSON 
       |    S.S OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON 
       |
       |         John W. Littlechild
_______|______________________________________________________________________
       |
    2  |    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*    (a)  [ ] 
       |                                                         (b)  [ ] 
_______|_______________________________________________________________________
       |
    3  |    SEC USE ONLY
_______|_______________________________________________________________________
       |
    4  |    SOURCE OF FUNDS*
       |         N/A
_______|_______________________________________________________________________
       |
    5  |    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDING IS REQUIRED 
       |    PURSUANT TO ITEMS 2(3) OR 2(e)                             [ ]      
_______|_______________________________________________________________________
       |
    6  |    CITIZENSHIP OR PLACE OR ORGANIZATION
       |         U.S.A.
_______|_______________________________________________________________________
               |     |
  NUMBER OF    |  7  |   SOLE VOTING POWER
   SHARES      |     |   
BENEFICIALLY   |_____|________________________________________________________
  OWNED BY     |     |
   EACH        |  8  |   SHARED VOTING POWER                                    
 REPORTING     |     |   4,482,385
  PERSON       |_____|________________________________________________________
   WITH        |     |
               |  9  |   SOLE DISPOSITIVE POWER
               |     |   
               |_____|________________________________________________________  
               |     |
               | 10  |   SHARED DISPOSITIVE POWER             
               |     |   4,482,385
_______________|_____|_________________________________________________________
       |
   11  |   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
       |   4,482,385
_______|_______________________________________________________________________
       |
   12  |   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
       |   CERTAIN SHARES*                                             [ ]
_______|_______________________________________________________________________
       |
   13  |   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
       |   33.8%
_______|_______________________________________________________________________
       |
   14  |   TYPE OF REPORTING PERSON
       |   IN
_______|_______________________________________________________________________
                      *SEE INSTRUCTIONS BEFORE FILLING OUT

<PAGE>
______________________                                       ___________________

CUSIP No.  25243N103                  13D                    Page 11 of 21 Pages
          -----------                                            ----  ----
______________________                                       __________________
       |
    1  |    NAME OF REPORTING PERSON 
       |    S.S OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON 
       |
       |         William Crouse
_______|______________________________________________________________________
       |
    2  |    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*    (a)  [ ] 
       |                                                         (b)  [ ] 
_______|_______________________________________________________________________
       |
    3  |    SEC USE ONLY
_______|_______________________________________________________________________
       |
    4  |    SOURCE OF FUNDS*
       |         N/A
_______|_______________________________________________________________________
       |
    5  |    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDING IS REQUIRED 
       |    PURSUANT TO ITEMS 2(3) OR 2(e)                             [ ]      
_______|_______________________________________________________________________
       |
    6  |    CITIZENSHIP OR PLACE OR ORGANIZATION
       |         U.S.A.
_______|_______________________________________________________________________
               |     |
  NUMBER OF    |  7  |   SOLE VOTING POWER
   SHARES      |     |   
BENEFICIALLY   |_____|________________________________________________________
  OWNED BY     |     |
   EACH        |  8  |   SHARED VOTING POWER                                    
 REPORTING     |     |   4,482,385
  PERSON       |_____|________________________________________________________
   WITH        |     |
               |  9  |   SOLE DISPOSITIVE POWER
               |     |   
               |_____|________________________________________________________  
               |     |
               | 10  |   SHARED DISPOSITIVE POWER             
               |     |   4,482,385
_______________|_____|_________________________________________________________
       |
   11  |   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
       |   4,482,385
_______|_______________________________________________________________________
       |
   12  |   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
       |   CERTAIN SHARES*                                             [ ]
_______|_______________________________________________________________________
       |
   13  |   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
       |   33.8%
_______|_______________________________________________________________________
       |
   14  |   TYPE OF REPORTING PERSON
       |   IN
_______|_______________________________________________________________________
                      *SEE INSTRUCTIONS BEFORE FILLING OUT

<PAGE>
______________________                                       ___________________

CUSIP No.  25243N103                  13D                    Page 12 of 21 Pages
          -----------                                            ----  ----
______________________                                       __________________
       |
    1  |    NAME OF REPORTING PERSON 
       |    S.S OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON 
       |
       |         Mark Leschly
_______|______________________________________________________________________
       |
    2  |    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*    (a)  [ ] 
       |                                                         (b)  [ ] 
_______|_______________________________________________________________________
       |
    3  |    SEC USE ONLY
_______|_______________________________________________________________________
       |
    4  |    SOURCE OF FUNDS*
       |         N/A
_______|_______________________________________________________________________
       |
    5  |    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDING IS REQUIRED 
       |    PURSUANT TO ITEMS 2(3) OR 2(e)                             [ ]      
_______|_______________________________________________________________________
       |
    6  |    CITIZENSHIP OR PLACE OR ORGANIZATION
       |         U.S.A.
_______|_______________________________________________________________________
               |     |
  NUMBER OF    |  7  |   SOLE VOTING POWER
   SHARES      |     |   
BENEFICIALLY   |_____|________________________________________________________
  OWNED BY     |     |
   EACH        |  8  |   SHARED VOTING POWER                                    
 REPORTING     |     |   1,286,000
  PERSON       |_____|________________________________________________________
   WITH        |     |
               |  9  |   SOLE DISPOSITIVE POWER
               |     |   
               |_____|________________________________________________________  
               |     |
               | 10  |   SHARED DISPOSITIVE POWER             
               |     |   1,286,000
_______________|_____|_________________________________________________________
       |
   11  |   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
       |   1,286,000
_______|_______________________________________________________________________
       |
   12  |   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
       |   CERTAIN SHARES*                                             [ ]
_______|_______________________________________________________________________
       |
   13  |   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
       |   9.7%
_______|_______________________________________________________________________
       |
   14  |   TYPE OF REPORTING PERSON
       |   IN
_______|_______________________________________________________________________
                      *SEE INSTRUCTIONS BEFORE FILLING OUT

<PAGE>

______________________                                       ___________________

CUSIP No.  25243N103                  13D                    Page 13 of 21 Pages
          -----------                                            ----  ----
______________________                                       __________________

Item 1.      Security and Issuer

              (a)    Title of Class of Securities

                     Common Stock, $0.01 par value ("Shares").

              (b)    Name of Issuer

                     Diacrin, Inc.

              (c)    Address of Issuer's Principal Executive Officers

                     Building 96, 13th Street
                     Charlestown Navy Yard
                     Charlestown, Massachusetts 02129


Item 2.      Identity and Background

              (a)    This statement if filed by HealthCare Ventures II, L.P.
                     ("HCV II"), HealthCare Partners II, L.P. ("HCP II"),
                     HealthCare Ventures III, L.P. ("HCV III"), HealthCare
                     Partners III, L.P. ("HCP III"), HealthCare Ventures IV,
                     L.P. ("HCV IV"), HealthCare Partners IV, L.P. ("HCP IV"),
                     Dr. Cavanaugh and Messrs. Werner, Littlechild, Crouse and
                     Leschly. See attached Exhibit A which is a copy of their
                     agreement in writing to file this statement on behalf of
                     each of them.(1)

              (b)    The business address for HCV II, HCP II, HCV III, HCP III,
                     HCV IV, HCP IV, Dr. Cavanaugh and Messrs. Werner and Crouse
                     is 44 Nassau Street, Princeton, New Jersey 08542. The
                     business address for Messrs. Littlechild and Leschly is One
                     Kendall Square, Building 300, Cambridge Massachusetts
                     02139.

              (c)    James H. Cavanaugh, Ph.D. is the President of
                     HealthCare Ventures LLC ("HCV"), the management company for
                     HCV II, HCV III and HCV IV. Messrs. Werner and Crouse are
                     each a Managing Director of HCV. Dr. Cavanaugh and Messrs.
                     Werner, Littlechild and Crouse are general partners of HCP
                     II and Dr. Cavanaugh and Messrs. Werner, Littlechild,
                     Crouse and Leschly are general partners of HCP III and HCP
                     IV. Mr. Littlechild is also a director of the Issuer.

              (d)    Each of HCV II, HCP II, HCV III, HCP III, HCV IV, HCP IV,
                     Dr. Cavanaugh and Messrs. Werner, Littlechild, Crouse and
                     Leschly have not, during the last five years, been
                     convicted in a criminal proceeding (excluding traffic
                     violations or similar

- --------

(1)    Dr. Cavanaugh and Messrs. Werner, Littlechild and Crouse are general
       partners of HCP II, which is the general partner of HCV II, and Dr.
       Cavanaugh and Messrs. Werner, Littlechild, Crouse and Leschly are general
       partners of each of HCP III and HCP IV, which is the general partner of
       each of HCV III and HCV IV, respectively, the record holder of Issuer's
       securities.


<PAGE>
______________________                                       ___________________

CUSIP No.  25243N103                  13D                    Page 14 of 21 Pages
          -----------                                            ----  ----
______________________                                       __________________


                     misdemeanors).

              (e)    Each of HCV II, HCP II, HCV III, HCP III, HCV IV, HCP IV,
                     Dr. Cavanaugh and Messrs. Werner, Littlechild, Crouse and
                     Leschly have not been, during the last five years, a party
                     to a civil proceeding of a judicial or administrative body
                     of competent jurisdiction and as a result of any such
                     proceeding was or is subject to a judgment, decree or final
                     order enjoining future violations of, or prohibiting or
                     mandating activities subject to federal or state securities
                     laws or finding any violations with respect to such laws.

              (f)    HCV II, HCP II, HCV III, HCP III, HCV IV and HCP IV are
                     limited partnerships organized under the laws of the State
                     of Delaware. Dr. Cavanaugh and Messrs. Werner, Littlechild,
                     Crouse and Leschly are United States citizens.


Item 3.      Source and Amount of Funds or Other Considerations

             Not applicable.

Item 4.      Purpose of Transaction

             Not applicable.

Item 5.      Interest in Securities of the Issuer

              (a)    As of January 1, 1998: (i) HCV II and HCP II beneficially
                     owned 3,196,385 of Issuer's Common Stock; (ii) HCV III and
                     HCP III beneficially owned 994,078 Shares of Issuer's
                     Common Stock; (iii) HCV IV and HCP IV beneficially owned
                     291,922 Shares of Issuer's Common Stock; (iv) Dr. Cavanaugh
                     and Messrs. Werner, Littlechild and Crouse beneficially
                     owned 4,482,385 Shares of Issuer's Common Stock; and (v)
                     Mr. Leschly beneficially owned 1,286,000 Shares of Issuer's
                     Common Stock.

                     As of January 1, 1998: (i) the 3,196,385 Shares of Issuer's
                     Common Stock beneficially owned by HCV II and HCP II
                     constitute 24.1% of Issuer's Shares, outstanding; (ii) the
                     994,078 Shares of Issuer's Common Stock beneficially owned
                     by HCV III and HCP III constitute 7.5% of Issuer's Shares
                     outstanding; (iii) the 291,922 Shares of Issuer's Common
                     Stock beneficially owned by HCV IV and HCP IV constitute
                     2.2% of Issuer's Shares outstanding; (iv) the 4,482,385
                     Shares of Issuer's Common Stock beneficially owned by Dr.
                     Cavanaugh and Messrs. Werner, Littlechild and Crouse
                     constitute 33.8% of Issuer's Shares outstanding; and (v)
                     the 1,286,000 Shares of Issuer's Common Stock beneficially
                     owned by Mr. Leschly constitute 9.7% of Issuer's Shares
                     outstanding.


<PAGE>
______________________                                       ___________________

CUSIP No.  25243N103                  13D                    Page 15 of 21 Pages
          -----------                                            ----  ----
______________________                                       __________________


              (b)    Number of shares as to which such person has:

                     (i)    sole power to vote or to direct the vote:

                            Inapplicable.

                     (ii)   shared power to vote or to direct the vote:

                            HCV II and HCP II share the power to vote or to
                            direct the vote of those Shares owned by HCV II. HCV
                            III and HCP III share the power to vote or to direct
                            the vote of those Shares owned by HCV III. HCV IV
                            and HCP IV share the power to vote or to direct the
                            vote of those Shares owned by HCV IV. Dr. Cavanaugh
                            and Messrs. Werner, Littlechild and Crouse share the
                            power to vote or to direct the vote of those Shares
                            owned by HCV II and Dr. Cavanaugh and Messrs.
                            Werner, Littlechild, Crouse and Leschly share the
                            power to vote or to direct the vote of those Shares
                            owned by HCV III and HCV IV.

                     (iii)  sole power to dispose or to direct the disposition
                            of:

                            Inapplicable.

                     (iv)   shared power to dispose of or to direct the
                            disposition of:

                            HCV II and HCP II share the power to dispose of or
                            to direct the disposition of those Shares owned by
                            HCV II. HCV III and HCP III share the power to
                            dispose of or to direct the disposition of those
                            Shares owned by HCV III. HCV IV and HCP IV share the
                            power to dispose of or to direct the disposition of
                            those Shares owned by HCV IV. Dr. Cavanaugh and
                            Messrs. Werner, Littlechild and Crouse share the
                            power to dispose of or to direct the disposition of
                            those Shares owned by HCV II, HCV III and HCV IV.

              (c)    On January 1, 1998, Mr. Leschly became a general partner of
                     each of HCP III and HCP IV and, accordingly, became the
                     beneficial ownership of those Shares owned by HCV III and
                     HCV IV.

              (d)    Inapplicable

              (e)    Inapplicable

Item 6.       Contracts, Arrangements, Understandings or Relationship with
              respect to Securities of the Issuer

              On March 26, 1992, HCV III and HCV IV entered into an InterFund
              Agreement which provides for HCV III and HCV IV to coordinate
              their investment activities so as to acquire, hold and dispose of
              identical securities in proportion to their respective contributed
              capital.


<PAGE>
______________________                                       ___________________

CUSIP No.  25243N103                  13D                    Page 16 of 21 Pages
          -----------                                            ----  ----
______________________                                       __________________

Item 7.       Materials to Be Filed as Exhibits

              (A)    Agreement to Jointly File


              (B)    InterFund Agreement dated as of March 26, 1992 between HCV
                     III and HCV IV.*



*Previously filed as an Exhibit to the Schedule 13D filed by HCV III and HCV IV
on June 9, 1995.


<PAGE>
______________________                                       ___________________

CUSIP No.  25243N103                  13D                    Page 17 of 21 Pages
          -----------                                            ----  ----
______________________                                       __________________


                                   SIGNATURES

                   After reasonable inquiry and to the best of my knowledge and
belief, I certify that the information set forth in this statement is true,
complete and correct.



Dated:  February 10, 1998                        HealthCare Ventures II, L.P.,
        Princeton, New Jersey                    by its General Partner, 
                                                 HealthCare Partners II, L.P.


                                                 By: /s/ Jeffrey Steinberg
                                                    --------------------------
                                                     A General Partner


Dated:  February 10, 1998                        HealthCare Partners II, L.P.
        Princeton, New Jersey

                                                 By: /s/ Jeffrey Steinberg
                                                    --------------------------
                                                     A General Partner


Dated:  February 10, 1998                        HealthCare Ventures III, L.P.
        Princeton, New Jersey                    by its General Partner, 
                                                 HealthCare Partners III, L.P.


                                                 By: /s/ Jeffrey Steinberg
                                                    --------------------------
                                                     A General Partner


Dated:  February 10, 1998                        HealthCare Partners III, L.P.
        Princeton, New Jersey

                                                 By: /s/ Jeffrey Steinberg
                                                    --------------------------
                                                     A General Partner


Dated:  February 10, 1998                        HealthCare Ventures IV, L.P.
        Princeton, New Jersey                    by its General Partner,
                                                 HealthCare Partners IV, L.P.


                                                 By: /s/ Jeffrey Steinberg
                                                    --------------------------
                                                     A General Partner


<PAGE>
______________________                                       ___________________

CUSIP No.  25243N103                  13D                    Page 18 of 21 Pages
          -----------                                            ----  ----
______________________                                       __________________


Dated:  February 10, 1998                      HealthCare Partners IV, L.P.
        Princeton, New Jersey

                                               By: /s/ Jeffrey Steinberg
                                                  --------------------------
                                                   A General Partner


Dated:  February 10, 1998                      By: /s/ Jeffrey Steinberg
        Princeton, New Jersey                      ----------------------------
                                                      James H. Cavanaugh, Ph.D.


Dated:  February 10, 1998                      By: /s/ Jeffrey Steinberg
        Princeton, New Jersey                      ----------------------------
                                                      Harold R. Werner


Dated:  February 10, 1998                      By: /s/ Jeffrey Steinberg
        Cambridge, Massachusetts                   ----------------------------
                                                      John W. Littlechild


Dated:  February 10, 1998                      By: /s/ Jeffrey Steinberg
        Princeton, New Jersey                      ----------------------------
                                                      William Crouse


Dated:  February 10, 1998                      By: /s/ Jeffrey Steinberg
        Cambridge, Massachusetts                   ----------------------------
                                                      Mark Leschly



<PAGE>
______________________                                       ___________________

CUSIP No.  25243N103                  13D                    Page 19 of 21 Pages
          -----------                                            ----  ----
______________________                                       __________________


                                  EXHIBIT INDEX



       Exhibit                  Description                           Page No.
       -------                  -----------                           --------


      Exhibit A            Agreement to Jointly File                     20



<PAGE>
______________________                                       ___________________

CUSIP No.  25243N103                  13D                    Page 20 of 21 Pages
          -----------                                            ----  ----
______________________                                       __________________


                                    EXHIBIT A

                                    AGREEMENT

                          JOINT FILING OF SCHEDULE 13D


                  The undersigned hereby agree to jointly prepare and file with
regulatory authorities a Schedule 13D and any future amendments thereto
reporting each of the undersigned's ownership of securities of Diacrin, Inc. and
hereby affirm that such Schedule 13D is being filed on behalf of each of the
undersigned.



Dated:  February 10, 1998                 HealthCare Ventures II, L.P.,
        Princeton, New Jersey                      by its General Partner, 
                                                   HealthCare Partners II, L.P.


                                          By: /s/ Jeffrey Steinberg
                                              ---------------------------------
                                              A General Partner


Dated:  February 10, 1998                 HealthCare Partners II, L.P.
        Princeton, New Jersey

                                          By: /s/ Jeffrey Steinberg
                                              ---------------------------------
                                              A General Partner


Dated:  February 10, 1998                 HealthCare Ventures III, L.P.
        Princeton, New Jersey                      by its General Partner, 
                                                   HealthCare Partners III, L.P.


                                          By: /s/ Jeffrey Steinberg
                                              ---------------------------------
                                              A General Partner


Dated:  February 10, 1998                 HealthCare Partners III, L.P.
        Princeton, New Jersey

                                          By: /s/ Jeffrey Steinberg
                                              ---------------------------------
                                              A General Partner


<PAGE>
______________________                                       ___________________

CUSIP No.  25243N103                  13D                    Page 21 of 21 Pages
          -----------                                            ----  ----
______________________                                       __________________

Dated:  February 10, 1998                 HealthCare Ventures IV, L.P.
        Princeton, New Jersey                      by its General Partner, 
                                                   HealthCare Partners IV, L.P.


                                          By: /s/ Jeffrey Steinberg
                                              ---------------------------------
                                              A General Partner


Dated:  February 10, 1998                   HealthCare Partners IV, L.P.
        Princeton, New Jersey

                                          By: /s/ Jeffrey Steinberg
                                              ---------------------------------
                                              A General Partner


Dated:  February 10, 1998                 By: /s/ Jeffrey Steinberg
        Princeton, New Jersey                 ---------------------------------
                                              James H. Cavanaugh, Ph.D.



Dated:  February 10, 1998                 By: /s/ Jeffrey Steinberg
        Princeton, New Jersey                 ---------------------------------
                                              Harold R. Werner



Dated:  February 10, 1998                 By: /s/ Jeffrey Steinberg
        Cambridge, Massachusetts              ---------------------------------
                                              John W. Littlechild



Dated:  February 10, 1998                 By: /s/ Jeffrey Steinberg
        Princeton, New Jersey                 ---------------------------------
                                              William Crouse


Dated:  February 10, 1998                 By: /s/ Jeffrey Steinberg
        Cambridge, Massachusetts              ---------------------------------
                                              Mark Leschly






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