BIO PLEXUS INC
3, 1998-11-30
SURGICAL & MEDICAL INSTRUMENTS & APPARATUS
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<PAGE>   1

                     U.S. SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                     FORM 3

            INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

    Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934,
       Section 17(a) of the Public Utility Holding Company Act of 1935 or
               Section 30(f) of the Investment Company Act of 1940

________________________________________________________________________________
1.   Name and Address of Reporting Person*

Gross,                            Herman
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   (Last)                            (First)              (Middle)

12 Jordan Drive
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                                    (Street)

Great Neck,                       NY                      11021
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   (City)                            (State)                (Zip)

________________________________________________________________________________
2.   Date of Event Requiring Statement (Month/Day/Year)

11/23/98
________________________________________________________________________________
3.   IRS Identification Number of Reporting Person, if an Entity (Voluntary)


________________________________________________________________________________
4.   Issuer Name and Ticker or Trading Symbol

Bio-Plexus, Inc. (BPLX)
________________________________________________________________________________
5.   Relationship of Reporting Person to Issuer
     (Check all applicable)

     [X]  Director                             [_]  10% Owner
     [_]  Officer (give title below)           [_]  Other (specify below)


________________________________________________________________________________
6.   If Amendment, Date of Original (Month/Day/Year)


________________________________________________________________________________
7.   Individual or Joint/Group Filing  (Check applicable line) 

     [X]  Form Filed by One Reporting Person

     [_]  Form Filed by More than One Reporting Person

________________________________________________________________________________
             Table I -- Non-Derivative Securities Beneficially Owned
________________________________________________________________________________
<TABLE>
<CAPTION>
                                                                 3. Ownership Form:
                                      2. Amount of Securities       Direct (D) or  
1. Title of Security                     Beneficially Owned         Indirect (I)       4. Nature of Indirect Beneficial Ownership
   (Instr. 4)                            (Instr. 4)                 (Instr. 5)            (Instr. 4)                              
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<S>                                      <C>                         <C>                  <C>
Common Stock                              1,022,568                      D

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====================================================================================================================================
</TABLE>

*    If the Form is filed by more than one  Reporting  Person,  see  Instruction
     5(b)(v).

Reminder: Report on a separate line for each class of securities beneficially
          owned directly or indirectly.

                           (Print or Type Responses)

                                                                          (Over)
(Form 3-07/98)

<PAGE>   2


FORM 3 (continued)

              Table II -- Derivative Securities Beneficially Owned
         (e.g., puts, calls, warrants, options, convertible securities)

________________________________________________________________________________
<TABLE>
<CAPTION>
                                                                                                        5. Owner-
                                                    3. Title and Amount of Securities                      ship
                                                       Underlying Derivative Security                      Form of
                         2. Date Exercisable           (Instr. 4)                                          Derivative
                            and Expiration Date     ---------------------------------    4. Conver-        Security:
                            (Month/Day/Year)                               Amount           sion or        Direct      6. Nature of
                         ----------------------                            or               Exercise       (D) or         Indirect
                         Date       Expira-                                Number           Price of       Indirect       Beneficial
1. Title of Derivative   Exer-      tion                                   of               Derivative     (I)            Ownership
   Security (Instr. 4)   cisable    Date(2)         Title                  Shares           Security       (Instr. 5)     (Instr. 5)
- ------------------------------------------------------------------------------------------------------------------------------------
<S>                      <C>        <C>             <C>                    <C>           <C>            <C>            <C>
Directors Stock Option
(1) (Right to Buy)       11/23/99   11/23/03        Common Stock           1,000               3.00           D

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</TABLE>



/s/ Herman Gross                                                 11/24/98
- ---------------------------------------------            -----------------------
      **Signature of Reporting Person                             Date

Explanation of Responses:
(1) Granted pursuant to Issuer's 1995 Non-Employee Directors' Stock Option Plan.
(2) Option exercisable for the lesser of one (1) year from termination as a 
    director or five (5) years from date of grant.
**  Intentional misstatements or omissions of facts constitute Federal Criminal
    Violations.

    See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

Note:  File three copies of this Form, one of which must be manually signed.
       If space provided is insufficient. See Instruction 6 for procedure.


                                                                          Page 2

                           (Print or Type Responses)


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