BIOCHEM PHARMA INC
SC 13E3/A, 2000-11-21
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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<PAGE>   1
                       SECURITIES AND EXCHANGE COMMISSION,
                             WASHINGTON, D.C. 20549
                               -------------------

                                 SCHEDULE 13E-3

                                 (RULE 13e-100)

           TRANSACTION STATEMENT UNDER SECTION 13(e) OF THE SECURITIES
                 EXCHANGE ACT OF 1934 AND RULE 13e-3 THEREUNDER

           RULE 13e-3 TRANSACTION STATEMENT UNDER SECTION 13(e) OF THE
                         SECURITIES EXCHANGE ACT OF 1934

                             (AMENDMENT NO. 1)

                           CliniChem Development Inc.
--------------------------------------------------------------------------------
                              (Name of the Issuer)

                               BioChem Pharma Inc.
--------------------------------------------------------------------------------
                      (Name of Person(s) Filing Statement)

                              Class A Common Shares
--------------------------------------------------------------------------------
                         (Title of Class of Securities)

                                   186-906-102
--------------------------------------------------------------------------------
                      (CUSIP Number of Class of Securities)

                            Charles-A. Tessier, Esq.
                Vice President, Legal Affairs and General Counsel
                          275 Armand Frappier Boulevard
                          Laval, Quebec, Canada H7V 4A7
                                 (450) 978-7768

                                 With a copy to:

                               Lance C. Balk, Esq.
                                Kirkland & Ellis
                                Citigroup Center
                              153 East 53rd Street
                            New York, New York 10022
                                 (212) 446-4800
--------------------------------------------------------------------------------
  (Name, Address and Telephone Numbers of Person Authorized to Receive Notices
         and Communications on Behalf of the Person(s) Filing Statement)

--------------------------------------------------------------------------------
         This statement is filed in connection with (check the appropriate box):

         a.  [ ]  The filing of solicitation materials or an information
                  statement subject to Regulation 14A, Regulation 14C or Rule
                  13e-3(c) under the Securities Exchange Act of 1934

         b.  [ ]  The filing of a registration statement under the Securities
                  Act of 1933.

         c.  [ ]  A tender offer.

         d.  [x]  None of the above.
<PAGE>   2
         Check the following box if the soliciting materials or information
statement referred to in checking box (a) are preliminary copies: [ ]

         Check the following box if the filing is a final amendment reporting
the results of the transaction: [ ]

--------------------------------------------------------------------------------


                            CALCULATION OF FILING FEE
<TABLE>
<CAPTION>
--------------------------------------------------------------------------------
         Transaction                               Amount of
       Valuation(1)(3)                          Filing Fee(2)(3)
<S>                                             <C>
       US $25,985,430                              US $5,197
--------------------------------------------------------------------------------
</TABLE>

(1)      Estimated solely for the purpose of calculating the filing fee. The
         transaction valuation is based upon the aggregate exercise price of the
         stock purchase option granted to BioChem under CliniChem's amended
         Articles of Incorporation of Cdn $50,000,000 or Cdn $18.43 per share
         for all issued and outstanding shares of Class A Common Stock of
         CliniChem Development Inc. As of October 26, 2000, BioChem beneficially
         owned 559,674 Class A common shares. The transaction valuation
         indicated above was calculated by multiplying (a) the per-share
         exercise price of Cdn $18.43 by (b) 2,153,586 which represents the
         number of Class A common shares not owned by BioChem.

(2)      The amount of the filing fee, calculated in accordance with Section 13
         of the Securities Exchange Act of 1934, as amended, equals 1/50th of
         one percent of the exercise price to be paid by BioChem Pharma Inc.
         pursuant to the stock purchase option granted to BioChem under
         CliniChem's amended Articles of Incorporation.

(3)      The exchange rate of US $.6547 used to calculate the Transaction
         Valuation and the Amount of the Filing Fee, was based on the noon
         buying rate on October 27, 2000 for cable transfers in Canadian dollars
         for one United Sates dollar as certified for customs purposes by the
         Federal Reserve Bank of New York.

         Check the box if any part of the fee is offset as provided by Exchange
         Act Rule 0-ll(a)(2) and identify the filing with which the offsetting
         fee was previously paid. Identify the previous filing by registration
         statement number, or the Form or Schedule and the date of its filing.
         [ ]

Amount Previously Paid: ____________________     Filing Party __________________

Form or Registration No. ___________________     Date Filed: ___________________



                                       2
<PAGE>   3
INTRODUCTION

This Schedule 13E-3 Transaction Statement relates to the intended exercise by
BioChem Pharma Inc., a Canadian corporation, of the option granted to it under
the amended Articles of Incorporation of CliniChem Development Inc., a Canadian
corporation, to purchase all of the issued and outstanding Class A common shares
of CliniChem. The option granted to BioChem under CliniChem's amended Articles
of Incorporation is referred to in this Transaction Statement as the purchase
option. Notwithstanding the filing of this Transaction Statement, BioChem
disclaims application of Rule 13e-3 of the Securities Exchange Act of 1934 to
the transaction described herein.

In this Transaction Statement, references to "U.S. dollars" or "US $" are to
United States currency, and references to "Canadian dollars" or "Cdn $" are to
Canadian Currency. UNLESS OTHERWISE NOTED, ALL REFERENCES TO FINANCIAL
TRANSACTIONS IN THIS TRANSACTION STATEMENT ARE TO CANADIAN DOLLARS.

ITEM 1.  SUMMARY TERM SHEET.

The information set forth under the caption "Summary of Terms" in the notice to
shareholders of CliniChem attached hereto as Exhibit 99(a)(1) is hereby
incorporated by reference.

ITEM 2.  SUBJECT COMPANY INFORMATION.

(a)      CliniChem is the issuer of the class of equity that is the subject of
         this filing. The address of CliniChem's principal executive office is
         275 Armand Frappier Boulevard, Laval, Quebec, Canada H7V 4A7. The
         telephone number of CliniChem's principal executive office is
         (450) 681-1744.

(b)      The exact title of the class of equity security that is the subject
         of this filing is Class A common shares of CliniChem. As of
         October 26, 2000, there were 2,713,260 Class A common shares issued and
         outstanding.

(c)      CliniChem's Class A common shares are traded on the Nasdaq National
         Market under the symbol "CCHE" and are traded in Canada on The Toronto
         Stock Exchange under the symbol "BCC.A". The following table sets
         forth, for the periods indicated, the range of high and low closing
         sales prices of the CliniChem Class A common shares on the Montreal
         Exchange (CliniChem's principal non-United States exchange until
         December 3, 1999), The Toronto Stock Exchange and the Nasdaq National
         Market.


                                       3
<PAGE>   4
<TABLE>
<CAPTION>
                          The Montreal Exchange(1)      The Toronto Stock Exchange     Nasdaq National Market
                          ---------------------         --------------------------     ----------------------
                                   Cdn $                          Cdn $                         US $
     Quarter Ending       High             Low           High                Low       High              Low
     --------------       ----             ---           ----                ---       ----              ---
<S>                       <C>              <C>           <C>                 <C>      <C>                <C>
        12/31/98           8.35             6.60          8.35                6.50      5.50              4.13
        03/31/99          11.00             7.05         11.00                7.00      6.91              4.50
        06/30/99          10.65             9.50         10.75                9.50      7.50              6.38
        09/30/99          11.50             9.40         11.50                9.50      8.13              6.38
        12/31/99          15.00            11.00         14.50               11.05      9.88              7.25
        03/31/00           --               --           17.00               12.50     11.88              8.75
        06/30/00           --               --           17.75               16.05     11.88             11.38
        09/30/00           --               --           18.00               15.75     12.00             10.00
</TABLE>

    (1)  The CliniChem Class A common shares ceased trading on the Montreal
         Exchange on December 3, 1999.

(d)      To the best of BioChem's knowledge after making a reasonable inquiry,
         CliniChem has paid no dividends on its Class A common shares during the
         past two years.

(e)      Not applicable.

(f)      Between January 28, 2000 and July 28, 2000, BioChem purchased a total
         of 559,674 Class A common shares in both open market and privately
         negotiated transactions. These shares represent approximately 20.6% of
         the issued and outstanding Class A common shares.

         Between January 28, 2000 and June 30, 2000, BioChem purchased a total
         of 163,400 Class A  common shares in open market transactions. The
         following table shows the high and low prices, as well as the average
         price, paid by BioChem for Class A common shares during each fiscal
         quarter between January 28, 2000 and June 30, 2000.


<TABLE>
<CAPTION>
                               The Toronto Stock Exchange         Nasdaq National Market
                               --------------------------         ----------------------
                                         Cdn $                             US $
           Quarter Ending      High      Low      Average      High        Low       Average
           --------------      ----      ---      -------      ----        ---       -------
<S>                            <C>      <C>       <C>         <C>        <C>         <C>
              03/31/00         16.75    16.00      16.67      11.625     11.625      11.625
              06/30/00         17.25    16.50      16.86      11.75      11.625      11.64
</TABLE>

         In addition, in a private transaction dated July 28, 2000, BioChem
         purchased 396,274 Class A common shares from Glaxo Wellcome Inc. See
         Item 5(a)(6) of this Transaction Statement.

ITEM 3.  IDENTITY AND BACKGROUND OF FILING PERSON

(a)      This filing is being made by BioChem Pharma Inc. BioChem's principal
         business address is 275 Armand Frappier Boulevard, Laval, Quebec,
         Canada H7V 4A7, and its business telephone number is (450) 978-7771. As
         the sole holder of CliniChem's issued and outstanding Class B common
         shares, BioChem has the right to appoint one member of CliniChem's
         board of directors. BioChem also beneficially owns approximately 20.6%
         of the issued and outstanding Class A common shares.

(b)      BioChem is an international biopharmaceutical company organized under
         the laws of Canada whose principal business is the research,
         development, manufacturing and

                                       4
<PAGE>   5
         marketing of innovative products for the prevention, detection and
         treatment of human diseases.

         During the past five years, BioChem has not been convicted in a
         criminal proceeding and has not been a party to a civil proceeding of a
         judicial or administrative body of competent jurisdiction that resulted
         in a judgement, decree or final order enjoining further violations of,
         or prohibiting activities subject to, federal or state securities laws
         or finding any violation of such laws.

(c)      BUSINESS AND BACKGROUND OF BIOCHEM'S DIRECTORS AND EXECUTIVE OFFICERS

         Frederick J. Andrew
         Chief Financial Officer
         275 Armand Frappier Boulevard
         Laval, Quebec, Canada H7V 4A7

         Frederick J. Andrew joined BioChem in 1997 as Chief Financial Officer.
         Prior to joining BioChem, he was Vice-President and Treasurer of BCE
         Inc., located at 1000 de la Gauchetiere, Montreal, Quebec, Canada, from
         1991 to 1997, Corporate Treasurer of Bell Canada from 1984 to 1991 and
         occupied various positions within the BCE Inc. group of companies from
         1964 to 1984. Mr. Andrew received a B.A. in economics from York
         University in 1964. Mr. Andrew is a citizen of Canada.

         Francesco Bellini
         Chief Executive Officer and Chairman of the Board
         275 Armand Frappier Boulevard
         Laval, Quebec, Canada H7V 4A7

         Francesco Bellini, O.C., Ph.D., a co-founder of BioChem, joined BioChem
         as President and Chief Executive Officer in September 1986. From 1984
         to September 1986, Dr. Bellini was the Director of the Biochemicals
         Division at the Institut Armand-Frappier and, from 1968 to 1984, he was
         a research scientist with Ayerst Laboratories. Dr. Bellini is a
         director of Molson Inc. and Industrial Alliance Life Insurance Co. Dr.
         Bellini received a B.Sc. in chemistry from Loyola College in Montreal
         in 1972 and a Ph.D. in organic chemistry from the University of New
         Brunswick in 1977. Dr. Bellini is a citizen of Canada.

         Gervais Dionne
         Chief Scientific Officer and Director
         275 Armand Frappier Boulevard
         Laval, Quebec, Canada H7V 4A7

         Gervais Dionne, Ph.D., a co-founder of BioChem, joined BioChem as
         Vice-President of Research and Development in 1986 and was recently
         appointed Chief Scientific Officer. From 1985 to 1986, he was the
         Chemical Products Director at the Institut Armand-Frappier, and from
         1984 to 1985, he was a Group Leader Research Scientist with Bio-Mega
         Inc. From 1976 until 1984, Dr. Dionne was a research scientist with
         Ayerst Laboratories. Dr. Dionne received a B.Sc. in chemistry from the
         Universite de Montreal in 1971 and a Ph.D. in organic chemistry from
         Laval University in 1976. Dr. Dionne is a citizen of Canada.


                                       5
<PAGE>   6
         Jean-Louis Fontaine
         Director (BioChem)
         Bombardier Inc.
         800 Rene-Levesque Boulevard West
         29th Floor
         Montreal, Quebec, Canada H3B 1Y8

         Jean-Louis Fontaine has been a director of BioChem since 1986 and was
         the Chairman of BioChem's Board of Directors until May 20, 2000. Mr.
         Fontaine serves as the Vice-Chairman of Corporate Affairs of Bombardier
         Inc. He was a Vice-President with Bombardier Inc. from June 1977 until
         August 1988. Bombardier Inc. is engaged in the design, development,
         manufacturing and marketing of transportation equipment, civil and
         military aerospace products and motorized consumer products. Mr.
         Fontaine is a director of AXA Insurance Inc. and Heroux Inc. Mr.
         Fontaine received a B.Sc. in mechanical engineering from the Universite
         de Sherbrooke in 1963, and an M.B.A. from the University of Western
         Ontario in 1977. Mr. Fontaine is a citizen of Canada.

         Jean-Francois Formela
         Director (BioChem)
         General Partner of Atlas Venture Fund III, L.P.
         222 Berkeley Street
         Boston, Massachusetts 02116

         Jean-Francois Formela, M.D., has been a director of BioChem since 1997.
         He has been the General Partner of Atlas Venture Fund III, L.P. since
         1993 and was previously the Senior Director, Medical Marketing and
         Scientific Affairs for Schering-Plough U.S., which he joined in 1989.
         Mr. Formela graduated in 1984 as a medical doctor from the Ecole de
         medecine de l'Universite de Paris and received an M.B.A. in 1989 from
         the Columbia Business School. Mr. Formela is a citizen of the United
         States.

         James A. Grant
         Director (BioChem)
         Stikeman Elliott
         1155 Rene-Levesque Boulevard West
         Suite 4000
         Montreal, Quebec, Canada H3B 3V2

         The Honorable James A. Grant, P.C., Q.C., has been a director of
         BioChem since 1986. He is a partner with the law firm of Stikeman
         Elliott and has been with that firm since 1962. He is a director of
         United Dominion Industries Ltd., CAE Industries Ltd., and a Canadian
         bank. Mr. Grant received a B.A. in arts in 1958 and a B.C.L. in law in
         1961, both from McGill University. Mr. Grant is a citizen of Canada.

         Roderick L. Henry
         Director (BioChem)
         Henrod Investments Inc.
         297 Lakeside, P.O. Box 148
         Knowlton, Quebec, Canada J0E 1V0

         Roderick L. Henry has been a director of BioChem since 1991. He is a
         director and Chairman of Atlas Copco Canada Inc., a wholesaler of
         equipment and machinery located at 745 Montreal-


                                       6
<PAGE>   7
         Toronto Boulevard, Dorval, Quebec, and is also the President of Henrod
         Investments Inc., 297 Lakeside, P.O. Box 148, Knowlton, Quebec, Canada
         JOE 1V0 an investment company. Until 1997 Mr. Henry was the Chairman
         and Chief Executive Officer of Wire Rope Industries, a manufacturer of
         wire rope located at 1800 McGill College Avenue, Suite 2400, Montreal,
         Quebec, Canada, H3A 3J6. He also serves as a director of CAE Industries
         Ltd., Atlas Copco Canada Ltd., Westroc Industries Ltd. and Brome Lake
         Ducks Ltd. Mr. Henry is a citizen of Canada.

         Jacques R. Lapointe
         President and Chief Operating Officer and Director
         275 Armand Frappier Boulevard
         Laval, Quebec, Canada H7V 4A7

         Jacques R. Lapointe joined BioChem on May 4, 1998 as President and
         Chief Operating Officer. Prior to joining BioChem, he was with Glaxo
         Wellcome Inc., since 1986 as President and Chief Executive Officer of
         Glaxo Canada Inc., then from 1994 as Managing Director and Chairman of
         Glaxo Wellcome UK Ltd., then for Glaxo Wellcome p1c as Regional
         Director with responsibilities for Australia, New Zealand and South
         Africa until October 1996, when he took over as Business Development
         and Information Systems Director with responsibilities for Global
         Commercial Development, OTC and Information Systems worldwide. Glaxo
         Wellcome is located at Glaxo Wellcome House, Berkeley Avenue,
         Greenford, Middlesex, UB6 0NN, United Kingdom. Mr. Lapointe has a B.
         Commerce and an M.B.A. (Finance) from Concordia University. Mr.
         Lapointe is a citizen of Canada.

         Francois Legault
         Executive Vice-President of Corporate Development and Investments
         275 Armand Frappier Boulevard
         Laval, Quebec, Canada H7V 4A7

         Francois Legault joined BioChem in 1987 as Vice-President, Finance and
         Treasurer, then became the Executive Vice-President, Finance,
         Administration and Treasurer until September 1997, when he was named
         Executive Vice-President, Investments and Subsidiaries. In 1998 he was
         appointed Executive Vice-President Corporate Development and
         Investments. Prior to joining BioChem, he was Finance Director of
         Societe Quebecoise des Transports from 1984 to 1987, and was a
         chartered accountant with Coopers & Lybrand from 1978 to 1984. He
         received a B.A.A. in business and accounting from Ecole des Hautes
         Etudes Commerciales in Montreal in 1978 and was admitted as a Chartered
         Accountant to the Ordre des Comptables Agrees du Quebec in 1980. Mr.
         Legault is a citizen of Canada.

         Guy Lord
         Senior Vice-President of Corporate Affairs and Secretary
         275 Armand Frappier Boulevard
         Laval, Quebec, Canada H7V 4A7

         Guy Lord was a director of BioChem from 1989 to 1999. In March 1999 he
         was appointed Senior Vice-President, Corporate Affairs and Secretary of
         BioChem. Until this appointment, he was a partner with the law firm of
         Desjardins Ducharme Stein Monast, located at 600 de la Gauchetiere
         Street West, Suite 2400, Montreal, Quebec, Canada H3B 4L8, since 1993
         and was with the law firm of Clark Lord Rochefort Fortier from 1989 to
         1993. Prior to that, Mr. Lord was a partner and National Director of
         Research in


                                       7
<PAGE>   8
         Taxation with the accounting firm of Samson Belair/Deloitte & Touche
         from 1986 to 1989. Mr. Lord received a B.A. in 1959 and a law degree in
         1962 from the Universite de Montreal, and a D. Phil, from Oxford
         University in 1969. He is a member of the Barreau du Quebec and the
         Canadian Bar Association. Mr. Lord is a citizen of Canada.

         Michel Perron
         Director (BioChem)
         Somiper Inc.
         2080 Rene-Levesque Boulevard West
         Montreal, Quebec, Canada  H3H 1R6

         Michel Perron has been a director of BioChem since 1993. He is Chairman
         and Chief Executive Officer of Somiper Inc., an investment company. Mr.
         Perron was Chairman and Chief Executive Officer of Uniforet Inc., a
         lumber business, and was also President and Chief Executive Officer of
         Normick Perron Inc., a lumber business, until 1990. Mr. Perron is a
         director of Natcan Trust and The National Bank of Canada. Mr. Perron
         received a degree in Commerce from St-Jerome College, Kitchener,
         Ontario. Mr. Perron is a citizen of Canada.

         J. Robert S. Prichard
         Director (BioChem)
         Plavelle House - Room 208
         78 Queen's Park Crescent
         Toronto, Ontario, Canada M5S 2C5

         J. Robert S. Prichard, O.C., has been a director of BioChem since July
         1999. He is Professor of Law and President Emeritus at the University
         of Toronto. Professor Prichard was appointed President of the
         University of Toronto in 1990 after having served as dean of the
         Faculty of Law of that university from 1984 to 1990. He has been
         associated with the University of Toronto in various academic
         capacities since 1979. Mr. Prichard received a Bachelor's degree in Law
         from the University of Toronto and a Master's from the Yale Law School.
         He also holds an M.B.A. from the University of Chicago Graduate School
         of Business. Mr. Prichard is a director of numerous public and private
         organizations. Mr. Prichard is a citizen of Canada.

         Guy Savard
         Director (BioChem)
         Merrill Lynch Canada Inc.
         1250 Rene-Levesque Boulevard West
         Suite 3100
         Montreal, Quebec, Canada H3B 4W8

         Guy Savard, C.M., has been a director of BioChem since 1995. Mr. Savard
         is Vice-Chairman, Chairman Quebec Operations and Director of Merrill
         Lynch Canada Inc. since 1998. In February 1995, he was appointed
         Vice-Chairman, President Quebec Operations, and Director of Midland
         Walwyn Capital Inc., which is located at 1250 Rene-Levesque Boulevard
         West, Suite 3100, Montreal, Quebec, Canada H3B 4W8. From 1990 to
         January 1995, he was President, Chief Operating Officer and Director of
         Caisse de depot


                                       8
<PAGE>   9
         et placement du Quebec. Mr. Savard is also a director of
         Industrial-Alliance Life Insurance Company, Reno-Depot Inc. and Ritvik
         Toys Inc. Mr. Savard is a Fellow of l'Ordre des Comptables Agrees du
         Quebec. He graduated from Universite Laval with a Bachelor of Commerce
         and a Master's degree in Commercial Sciences and Accounting Sciences.
         He perfected his management training at Harvard University in Boston.
         Mr. Savard is a citizen of Canada.

         Charles-A. Tessier
         Vice-President of Legal Affairs and General Counsel
         275 Armand Frappier Boulevard
         Laval, Quebec, Canada H7V 4A7

         Charles-A. Tessier is Vice-President Legal Affairs and General Counsel
         of BioChem. He joined BioChem as Vice-President, Legal Affairs and
         Corporate Secretary in 1996. Prior to joining BioChem, he practiced
         commercial law in his own law firm from 1980 to 1988, and from 1988
         until 1996, he was Vice-President, Secretary and General Counsel of DMR
         Group Inc., a multinational company in information technology located
         at 1000 Sherbrooke Street West, Suite 1600, Montreal, Quebec, Canada
         H3A 3RZ. Mr. Tessier received a B.A. in Administration in 1976 and a
         law degree in 1979 from the University of Ottawa. He is a member of the
         Barreau du Quebec and the Canadian Bar Association. Mr. Tessier is a
         citizen of Canada.

         Gerard Veilleux
         Director (BioChem)
         Power Communications Inc.
         751 Square Victoria
         Montreal, Quebec, Canada H2Y 2J3

         Gerard Veilleux, O.C., has been a director of BioChem since July 1999.
         He has been President of Power Communications Inc. and Vice-President
         of Power Corporation of Canada, a diversified management and holding
         company, since June 1994. He served as President and Chief Executive
         Officer of the Canadian Broadcasting Corporation from 1989 to 1993.
         From 1986 to 1989, he was Secretary of the Treasury Board, an agency of
         the Federal Government of Canada, and from 1982 to 1986 he served as
         Secretary to the Cabinet for Federal-Provincial Relations and Deputy
         clerk of the Privy Council. From 1963 to 1982, Mr. Veilleux worked in
         various capacities in the public service of the Federal Government of
         Canada. Mr. Veilleux has a Master's degree in Public Administration
         from Carleton University in Ottawa and a Bachelor of Commerce from
         Laval University. Mr. Veilleux is director of several public and
         private companies as well as a member of the Board of Governors of
         McGill University. Mr. Veilleux is a citizen of Canada.

         During the past five years, none of BioChem's Directors or Executive
         Officers has been convicted in a criminal proceeding (excluding traffic
         violations and similar misdemeanors), and none has been a party to a
         civil proceeding of a judicial or administrative body of competent
         jurisdiction that resulted in a judgment, decree or final order
         enjoining further violations of, or prohibiting activities subject to,
         federal or state securities laws, or finding any violations of such
         laws.





                                       9
<PAGE>   10
ITEM 4.  TERMS OF THE TRANSACTION.

(a)      As of October 26, 2000, BioChem holds 559,674 CliniChem Class A common
         shares.

         On January 10, 2000, BioChem disclosed in a press release that it
         intended to exercise the purchase option provided by CliniChem's
         amended Articles of Incorporation. The purchase option gives BioChem,
         as the sole holder of  CliniChem's issued and outstanding Class B
         common shares, the right to acquire all, but not less than all, of the
         issued and outstanding Class A common shares. BioChem has exercised the
         option to purchase the Class A common shares on or about December 15,
         2000 and to pay the aggregate exercise price of Cdn $50 million in
         cash. The exercise price was calculated according to a predetermined
         formula set out in CliniChem's amended Articles of Incorporation, which
         are incorporated by reference in this Transaction Statement. As a
         result of BioChem's exercise of the purchase option, each Class A
         common share will be exchanged for Cdn $18.43 in cash. BioChem may
         extend the date on which it completes the purchase of the issued and
         outstanding Class A common shares pursuant to the purchase option by
         delivering a notice to CliniChem of its decision to do so, if in its
         judgment an extension is necessary:

         (1)      to obtain any governmental or third party consent to purchase
                  the Class A common shares;

         (2)      to permit the expiration prior to the date BioChem completes
                  its purchase of the issued and outstanding Class A common
                  shares, of any statutory or regulatory waiting period; or

         (3)      to fulfill any other applicable requirements.

         On or about November 23, 2000, CliniChem will mail or deliver to each
         registered shareholder notice of BioChem's intention to acquire the
         Class A common shares on or about December 15, 2000. A copy of the form
         of notice that will be distributed to holders of Class A common shares
         is included as Exhibit 99(a)(1) to this Transaction Statement. BioChem
         will deposit the funds with General Trust of Canada, as payment agent,
         on or prior to the date of BioChem's purchase. BioChem will irrevocably
         instruct General Trust of Canada to distribute the purchase option
         exercise price pro rata to each person or entity who was a holder of
         Class A common shares at the close of business on the date of BioChem's
         purchase. In accordance with the terms of CliniChem's amended Articles
         of Incorporation, the holders of Class A common stock do not need to
         take any steps to approve BioChem's exercise of the purchase option.
         Transfer of title to all the issued and outstanding Class A common
         shares will be deemed to occur automatically on the date of BioChem's
         purchase, and thereafter CliniChem will treat BioChem as the sole
         holder of Class A common shares and the exercise price will be paid to
         holders of Class A common shares on the date of BioChem's purchase in
         accordance with their respective interests.

(c)      The terms of the transaction reported on this Transaction Statement
         will be the same for all holders of Class A common shares, provided,
         however, that registered shareholders who hold physical share
         certificates must submit their certificates to General Trust of Canada
         in order to receive the pro rata exercise price. Holders of Class A
         common shares who hold their shares in a brokerage account will have
         the relevant account automatically credited by the broker.



                                       10
<PAGE>   11
(d)      No appraisal rights are afforded under either applicable law or
         BioChem's notice to holders of Class A common shares of its intention
         to exercise the purchase option, and neither BioChem nor CliniChem will
         afford such rights. BioChem is not aware of any rights available to
         objecting holders of Class A common shares under applicable law.

(e)      BioChem is unaware, after making reasonable inquiry of CliniChem, of
         any grant of access to unaffiliated security holders to the corporate
         files of either CliniChem or BioChem or the appointment of counsel or
         appraisal services for unaffiliated security holders at the expense of
         either CliniChem or BioChem.

(f)      Not Applicable.

ITEM 5.  PAST CONTACTS, TRANSACTIONS, NEGOTIATIONS AND AGREEMENTS.

(a)      The nature and approximate dollar amount of all the transactions
         between BioChem and CliniChem that have occurred during the past two
         years are as follows:

                  In June 1998, BioChem entered into a series of agreements with
                  CliniChem. These agreements are described below in (1) - (5)
                  and in section (b) of this Item 5.

                  (1) On June 8, 1998, BioChem made a Cdn $150 million cash
                  contribution to CliniChem's capital. The shares issued by
                  CliniChem that were held by BioChem were exchanged for Class A
                  and Class B common shares of CliniChem. On June 26, 1998, each
                  holder of record of BioChem common shares received one Class A
                  common share for each 40 common shares of BioChem held on June
                  22, 1998. The fair value of the Class A common shares
                  distributed to BioChem's shareholders was approximately Cdn
                  $24 million.

                  (2) Under the terms of a technology license agreement, BioChem
                  and its affiliates granted to CliniChem an exclusive perpetual
                  license to use BioChem and affiliate technology to conduct
                  certain research programs and related activities, and to
                  manufacture and commercialize products worldwide. CliniChem
                  pays a fee to BioChem and its affiliates in exchange for the
                  exclusive perpetual technology license. The technology license
                  fee is payable monthly at a rate of Cdn $352,000 per month
                  over a period of 48 months. From June 10, 1998 to October 26,
                  2000, CliniChem paid or incurred an aggregate amount of Cdn
                  $10,102,000 to BioChem and its affiliates pursuant to the
                  technology license contract.

                  (3) Under the terms of a research and development agreement,
                  BioChem conducts various research activities on behalf of
                  CliniChem. CliniChem is required under the terms of the
                  research and development agreement to use available funds, as
                  defined in the contract, to repay BioChem for its research and
                  development expenses. From June 10, 1998 to October 26, 2000,
                  CliniChem paid or incurred an aggregate amount of Cdn
                  $131,645,000 to BioChem pursuant to the research and
                  development agreement.

                  (4) Under the terms of a product option agreement, CliniChem
                  granted BioChem and certain of its affiliates an option to
                  acquire all rights to certain or all products developed by


                                       11
<PAGE>   12
                  CliniChem. This option is exercisable on a country-by-country
                  basis for each product developed by CliniChem. From June 10,
                  1998 to October 26, 2000, BioChem paid or incurred an
                  aggregate amount of Cdn $19,000 to CliniChem pursuant to the
                  product option agreement.

                  (5) Under the terms of a services agreement, BioChem agreed to
                  provide CliniChem with administrative services, including
                  accounting, legal and other services for an annual fee of
                  $400,000. From June 10, 1998 to October 26, 2000, CliniChem
                  paid or incurred an aggregate amount of Cdn $1,133,000 to
                  BioChem pursuant to the services agreement.

                  (6) On July 28, 2000, BioChem purchased 396,274 Class A common
                  shares from Glaxo Wellcome Inc., pursuant to a privately
                  negotiated share purchase agreement dated July 27, 2000
                  between BioChem and Glaxo. At the time BioChem purchased these
                  Class A common shares from Glaxo, Glaxo, by virtue of the
                  number of Class A common shares it beneficially owned before
                  the sale to BioChem, may have been an affiliate of CliniChem.
                  The aggregate price that BioChem paid Glaxo for the shares was
                  US $3,816,119, or US $9.63 per share.

(b)      See Item 5(a)(4) above.

(c)      See Item 5(a)(6) above.

(e)      In January 1998, BioChem incorporated CliniChem under the Canada
         Business Corporations Act to conduct research and development of
         potential human therapeutic products, primarily for the treatment of
         cancer and HIV infection, and vaccine products, for the prevention of
         certain bacterial infectious diseases.

         CliniChem's amended Articles of Incorporation grant BioChem, as the
         holder of all of the issued and outstanding Class B common shares, the
         right to acquire all, but not less than all, of the issued and
         outstanding Class A common shares and the right to appoint one of
         CliniChem's Directors.

         The purchase option is exercisable by written notice given at any time
         from and after June 26, 1998 and ending on the earlier of (i) March 31,
         2003 or (ii) the 90th day after the date CliniChem provides BioChem (as
         the holder of the majority of the outstanding Class B common shares)
         with quarterly financial statements of CliniChem showing cash or cash
         equivalents of less than Cdn $5.0 million, although BioChem may, at its
         election, extend such period by providing additional funding, including
         through loans, for the continued conduct of any or all of CliniChem's
         research (but in no event beyond March 31, 2003).

         The amount payable upon the exercise of the purchase option, which is
         referred to in this Transaction Statement as the purchase option
         exercise price, is the greatest of:

                  (a)      25 times the aggregate of:

                           (1)      all worldwide payments made by and all
                                    worldwide payments due to be made by BioChem
                                    and certain of its affiliates with respect
                                    to all products for which the product option
                                    (as such term is defined in CliniChem's
                                    amended Articles of Incorporation)


                                       12
<PAGE>   13
                                    was exercised, for the four calendar
                                    quarters immediately preceding the quarter
                                    in which the purchase option is exercised;
                                    and

                           (2)      all payments that would have been made and
                                    all payments due to be made by BioChem and
                                    certain of its affiliates to CliniChem
                                    during the base period (as such term is
                                    defined in CliniChem's amended Articles of
                                    Incorporation) if the option to buy out
                                    CliniChem's right to receive payments with
                                    respect to acquired products (as such term
                                    is defined in CliniChem's amended Articles
                                    of Incorporation) had not previously been
                                    exercised for any acquired product on a
                                    country-by-country or global basis pursuant
                                    to the product option agreement (as such
                                    term is defined in CliniChem's amended
                                    Articles of Incorporation) with respect to
                                    any product;

                           less any amounts previously paid to exercise any
                           payment buy-out option for any CliniChem product (as
                           such term is defined in CliniChem's amended Articles
                           of Incorporation).

                  (b)      the fair market value of 420,000 BioChem common
                           shares as of the date BioChem elects to purchase the
                           issued and outstanding Class A common shares pursuant
                           to the purchase option;

                  (c)      Cdn $175 million plus any additional funds
                           contributed to CliniChem by BioChem less the
                           aggregate amount of all technology fee payments,
                           research and development costs and services agreement
                           payments paid or incurred by CliniChem as of the date
                           BioChem elects to purchase the issued and outstanding
                           Class A common shares pursuant to the purchase
                           option; and

                  (d)      Cdn $50 million.

         Not later than 20 business days following the date BioChem elects to
         purchase the issued and outstanding Class A common shares pursuant to
         the purchase option, CliniChem shall deliver to BioChem a balance sheet
         prepared by CliniChem and dated as of the date BioChem elects to
         purchase the issued and outstanding Class A common shares pursuant to
         the purchase option, together with (i) a statement and brief
         description of all the liabilities of CliniChem as of such date not
         reflected on such balance sheet; (ii) a statement of the amount of
         available funds remaining as of such date; and (iii) a statement of the
         total amounts paid by and due from CliniChem pursuant to the research
         and development agreement through date BioChem elects to purchase the
         issued and outstanding Class A common shares pursuant to the purchase
         option.

         Following receipt of the balance sheet referred to in the preceding
         paragraph and any investigation required by BioChem, but prior to the
         closing date for BioChem's purchase of the issued and outstanding Class
         A common shares pursuant to the purchase option, which date is referred
         to in this Transaction Statement as the closing date, BioChem shall
         determine the final purchase option exercise price and shall notify
         CliniChem of such determination.



                                       13
<PAGE>   14
         The final purchase option exercise price is an amount equal to the
         purchase option exercise price minus the amount by which the
         liabilities of CliniChem existing at the purchase option exercise price
         (other than liabilities under the research and development agreement,
         the service agreement and the technology license agreement and any debt
         owed to BioChem (which agreements are identified in CliniChem's amended
         Articles of Incorporation)) exceed the aggregate of CliniChem's then
         existing cash, cash equivalents and short term and long term
         investments (but excluding the amount of available funds under the
         research and development agreement remaining at such time).

         On the next business day following receipt by CliniChem of the
         determination of the final purchase option exercise price, CliniChem
         shall mail or deliver to each registered shareholder notice of the
         intention of BioChem to acquire the issued and outstanding Class A
         common shares on the closing date.

         This notice shall set out the final purchase option exercise price, the
         closing date and instructions as to the surrender to the certificates
         representing the issued and outstanding Class A common shares and with
         respect to the collection of the final purchase option exercise price
         by the holders of issued and outstanding Class A common shares.

         On or before the closing date, BioChem shall deposit, in trust for the
         benefit of the holders of issued and outstanding Class A common shares,
         the full amount of the final purchase option exercise price.

         BioChem shall provide irrevocable instructions to the payment agent to
         pay, on or after the closing date, the final purchase option exercise
         price to registered holders of issued and outstanding Class A common
         shares on presentation and surrender of the certificates representing
         the issued and outstanding Class A common shares.

         Transfer of title of all the issued and outstanding Class A common
         shares will be deemed to occur automatically on the closing date and
         thereafter CliniChem will treat BioChem as the sole holder of the
         issued and outstanding Class A common shares.

         At the time of the exercise of the purchase option, BioChem must elect
         to pay the purchase option exercise price in cash, common shares of
         BioChem or a combination of cash and common shares of BioChem.

         On January 10, 2000, BioChem disclosed in a press release that it
         intended to exercise the purchase option when CliniChem's funding ran
         out, which BioChem estimated was likely to occur before the end of
         calendar year 2000. BioChem has elected to purchase the shares on
         December 15, 2000 and to pay the exercise price for the purchase
         option, which was calculated according to a predetermined formula
         contained in CliniChem's amended Articles of Incorporation, in cash.

ITEM 6.  PURPOSES OF THE TRANSACTION AND PLANS OR PROPOSALS.

(b)      Following BioChem's purchase of all of the outstanding Class A common
         shares, CliniChem will be amalgamated with BioChem. See Item 7 for a
         discussion of BioChem's reasons for engaging in the transaction
         described in this Transaction Statement.

(c)      As noted in Item 6(b) above, following BioChem's purchase of all of the
         outstanding Class A common shares, CliniChem will be amalgamated with
         BioChem. BioChem anticipates de-listing CliniChem from the Nasdaq
         National Market and The Toronto Stock Exchange,


                                       14
<PAGE>   15
         filing a Form 15 with the Securities and Exchange Commission to suspend
         CliniChem's reporting requirements under the Securities Exchange Act of
         1934, and taking the required steps to revoke its status as a reporting
         issuer in Canada. BioChem also intends to replace CliniChem's board of
         directors with BioChem employees.

ITEM 7.  PURPOSES, ALTERNATIVES, REASONS AND EFFECTS.

(a)      The purpose of this transaction is to regain control over research and
         development activities conducted by and on behalf of CliniChem and to
         avoid the administrative costs relating to the operation of CliniChem.
         BioChem believes that it is in the best interests of BioChem and its
         stockholders to exercise the purchase option at this time.

(b)      Because BioChem is exercising a previously granted right, no
         alternatives to the exercise of the purchase option were considered.

(c)      The transaction is structured pursuant to the terms of the previously
         granted purchase option as set forth in CliniChem's amended Articles of
         Incorporation. BioChem is undertaking the transaction at this time
         because CliniChem's funding is expected to run out before the end of
         calendar year 2000, and BioChem does not wish to provide additional
         operating funds to CliniChem. Therefore, for the reasons described in
         Item 7(a) above, BioChem has determined that the exercise of the
         purchase option at this time was in the best interests of BioChem and
         its shareholders.

(d)      Because CliniChem will be amalgamated with BioChem, BioChem will
         directly own all of the assets of CliniChem upon completion of the
         amalgamation. See Item 6(c) of this Transaction Statement.

                               TAX CONSIDERATIONS

         THE FOLLOWING SUMMARY IS OF A GENERAL NATURE ONLY AND IS NOT INTENDED
         TO BE, NOR SHOULD IT BE CONSTRUED TO BE, LEGAL OR TAX ADVICE TO ANY
         PARTICULAR HOLDER OF CLINICHEM CLASS A COMMON SHARES. HOLDERS ARE
         ADVISED AND EXPECTED TO CONSULT WITH THEIR OWN TAX ADVISORS FOR ADVICE
         REGARDING THE INCOME TAX CONSEQUENCES TO THEM OF DISPOSING OF THEIR
         CLINICHEM CLASS A COMMON SHARES TO BIOCHEM IN EXCHANGE FOR CASH, HAVING
         REGARD TO THEIR OWN PARTICULAR CIRCUMSTANCES AND ANY OTHER CONSEQUENCES
         TO THEM OF SUCH TRANSACTION UNDER CANADIAN FEDERAL, PROVINCIAL, LOCAL
         AND FOREIGN TAX LAWS.

         UNITED STATES FEDERAL INCOME TAX CONSEQUENCES

         The following is a summary of the material United States federal income
         tax considerations to a United States holder arising from the purchase
         by BioChem of the CliniChem Class A common shares. A United States
         holder is a beneficial owner of CliniChem Class A common shares that
         is:

                  -   an individual citizen or resident of the United States;

                  -   a corporation created or organized in or under the laws of
                      the United States or any of its political subdivisions; or



                                       15
<PAGE>   16
                  -   an estate or trust the income of which is subject to
                      United States federal income taxation regardless of its
                      source.

         This summary deals only with a United States holder that holds
         CliniChem Class A common shares as a capital asset and does not address
         tax considerations applicable to United States holders that may be
         subject to special tax rules, such as:

                  -   dealers or traders in securities or currencies;

                  -   financial institutions or other United States holders that
                      treat income in respect of CliniChem Class A common shares
                      as financial services income;

                  -   insurance companies;

                  -   regulated investment companies;

                  -   tax-exempt entities;

                  -   United States holders that acquired CliniChem Class A
                      common shares upon the exercise of an employee stock
                      option or otherwise in connection with the performance of
                      services;

                  -   United States holders that hold CliniChem Class A common
                      shares as a part of a straddle or conversion transaction
                      or other arrangement involving more than one position;

                  -   United States holders that own, or are deemed for United
                      States tax purposes to own, ten percent or more of the
                      total combined voting power of all classes of the voting
                      stock of CliniChem;

                  -   United States holders that have a principal place of
                      business or "tax home" outside the United States; or

                  -   United States holders whose "functional currency" is not
                      the United States dollar.

         This summary is based upon the provisions of the United States Internal
         Revenue Code of 1986, as amended, and regulations, rulings and judicial
         decisions as of the date of this Transaction Statement; any such
         authority may be repealed, revoked or modified, perhaps with
         retroactive effect, so as to result in federal income tax consequences
         different from those discussed below. This summary has no binding
         effect or official status of any kind; we cannot assure you that the
         conclusions reached below would be sustained by a court if challenged
         by the Internal Revenue Service (the "Service"). We will not seek a
         ruling from the Service with respect to any aspect of the tax
         considerations described below.

         Because United States tax consequences may differ from one holder to
         the next, this summary does not purport to deal with all of the federal
         income tax considerations that might be relevant to you in light of
         your personal investment circumstances or status. In addition, this
         summary does not address the application of other United States taxes,
         such as the federal estate tax or alternative minimum tax, or state or
         local tax laws. Accordingly, you are advised to consult your own tax
         advisor in determining the specific tax consequences to you of
         BioChem's purchase of your CliniChem Class A common shares, including
         the application to your particular situation of the tax considerations
         discussed below, as well as the application of state, local or other
         tax laws. The statements of United States tax law set out below are
         based on the laws and


                                       16
<PAGE>   17
         interpretations in force as of the date of this Transaction Statement,
         and are subject to any changes occurring after that date.

         Sale of CliniChem Class A Common Shares

         The receipt of cash in exchange for CliniChem Class A common shares
         will be treated as a taxable transaction for United States federal
         income tax purposes. Accordingly, subject to the discussion below of
         the passive foreign investment company rules, you will recognize a gain
         or loss in an amount equal to the difference between the amount of cash
         that you receive, translated from Canadian dollars to United States
         dollars by reference to the spot currency exchange rate on the closing
         date, and the adjusted tax basis in your hands of the CliniChem Class A
         common shares surrendered in exchange therefor. Subject to the
         discussion below of the passive foreign investment company rules, the
         gain or loss that you recognize will be a capital gain or loss, and
         will be a long-term capital gain or loss if you have held the CliniChem
         Class A common shares for more than one year. You will recognize
         separate foreign currency gain or loss only to the extent that gain or
         loss arises on the actual disposition of Canadian dollars received. Any
         foreign currency gain or loss generally will be treated as ordinary
         income or loss.

         If you received CliniChem Class A common shares in the June 1998
         distribution by BioChem of such shares, then your initial tax basis in
         the CliniChem Class A common shares was equal to the fair market value
         of those shares on the date of the distribution (US$6.00 or Cdn$8.82).
         In other cases, your initial tax basis in CliniChem Class A common
         shares generally will be equal to the cost to you of those shares.
         Under the passive foreign investment company rules discussed below, if
         you acquired CliniChem Class A common shares from a decedent, then, in
         some circumstances, your initial tax basis in those shares will be
         equal to the lower of their fair market value and the basis of those
         shares in the hands of the decedent.

         Gain realized by a United States holder on the purchase of CliniChem
         Class A common shares by BioChem generally will be treated as United
         States source gain, and loss realized by a United States holder on the
         purchase generally will be treated as United States source loss, for
         United States foreign tax credit purposes.

         Passive Foreign Investment Company Considerations

         IN GENERAL. A special and adverse set of United States tax rules
         applies to a United States holder that holds an interest in a passive
         foreign investment company. In general, a passive foreign investment
         company is any foreign corporation, if (1) 75 percent or more of the
         gross income of the corporation for the taxable year is passive income
         or (2) the average percentage of assets held by the corporation during
         the taxable year that produce passive income or that are held for the
         production of passive income is at least 50 percent. Because
         essentially all of the income derived by CliniChem since its formation
         has been interest income, which is treated as passive income for
         passive foreign investment company purposes, we believe that CliniChem
         will be treated as a passive foreign investment company for its current
         taxable year and has been so treated for all of its prior taxable
         years.

         Because CliniChem is and has been treated as a passive foreign
         investment company, if you are not fully subject either to the
         qualified electing fund rules described below or to the mark-to-market
         rules described below, then you will be subject to a special and


                                       17
<PAGE>   18
         adverse tax and interest-charge regime with respect to any gain that
         you recognize in the purchase of your CliniChem Class A common shares
         by BioChem. In particular, (1) you will be required to allocate that
         gain ratably to each day during your holding period for the CliniChem
         Class A common shares, (2) you will be required to include in income as
         ordinary income the portion of the gain that is allocated to your
         current taxable year and (3) you will be taxable at the highest rate of
         taxation applicable to ordinary income on the portion of the gain that
         is allocated to prior taxable years, without regard to your other items
         of income and loss for such prior taxable years (deferred tax). The
         deferred tax for each prior year will be increased by an interest
         charge for the period from the due date for tax returns for the prior
         year to the due date for tax returns for the current taxable year
         (without regard to extensions), computed at the rates that apply to
         underpayments of tax; the interest charge generally will not be
         deductible by an individual taxpayer.

         Qualified Electing Fund Election. You may be able to avoid or mitigate
         the effect of the unfavorable tax and interest-charge regime described
         above if you make or have made a qualified electing fund election with
         respect to CliniChem. A qualified electing fund election effectively
         requires you to include in income currently your pro rata share of the
         ordinary earnings and net capital gain of CliniChem, without regard to
         the amount of any distributions made by CliniChem. Your tax basis in
         the CliniChem shares is increased by the amount that is included in
         your income pursuant to the qualified electing fund election.

         In general, a qualified electing fund election must be made by the due
         date, taking into account extensions, for the filing of your income tax
         return for your first taxable year to which the qualified electing fund
         election will apply. The effect of the qualified electing fund election
         is to treat CliniChem as a qualified electing fund for each of its
         taxable years ending with or within a taxable year of yours for which
         the qualified electing fund election is effective. If you have had a
         qualified electing fund election in effect as to CliniChem for each of
         CliniChem's taxable years that is included in your holding period for
         the CliniChem Class A common shares, then you will not be subject to
         the adverse tax and interest-charge regime described above, and any
         gain that you recognize on the purchase of your shares by BioChem will
         be treated as capital gain under the non-passive foreign investment
         company rules described above. If you make or have made a qualified
         electing fund election for CliniChem, but that election has not been in
         effect for each of CliniChem's taxable years that is included in your
         holding period for the CliniChem Class A common shares, then the
         adverse tax and interest-charge regime described above will apply,
         notwithstanding your qualified electing fund election, to gain that you
         recognize on the purchase of your shares by BioChem, unless you make or
         have made a so-called "purging" election to recognize gain as if you
         sold and reacquired your CliniChem Class A common shares as of the
         first day of CliniChem's first taxable year to which your qualified
         electing fund election applies (the deemed sale date). If you make or
         have made the purging election, then any gain that you recognize on the
         deemed sale, based on the fair market value of the CliniChem Class A
         common shares on the deemed sale date, will be subject to the tax and
         interest-charge regime, but your CliniChem Class A common shares
         thereafter will be fully subject to the qualified electing fund
         provisions. You may make the purging election in an original or amended
         return for the taxable year that includes the deemed sale date. You are
         urged to consult your own tax advisor as to the advisability and
         effects of making a qualified electing fund election or a purging
         election.



                                       18
<PAGE>   19
         Mark-to-Market Election. We believe that the CliniChem Class A common
         shares should be treated as "marketable" stock, as defined in
         applicable Treasury regulations, for each calendar year since the
         distribution. As a consequence, you may be able to avoid the
         unfavorable tax and interest-charge regime described above if you have
         elected, under Section 1296 of the Internal Revenue Code, to mark the
         CliniChem shares to market as of the close of each taxable year. A
         mark-to-market election requires you to include in income each year as
         ordinary income an amount equal to the increase in value of the
         CliniChem Class A common shares for that year, regardless of whether
         you actually sell the CliniChem shares. You generally are allowed a
         deduction for the decrease in value of the CliniChem Class A common
         shares for the taxable year, to the extent of the amount of gain
         previously included in income under the mark-to-market rules, reduced
         by prior deductions under the mark-to-market rules. The tax basis of
         the CliniChem Class A common shares in your hands is increased by the
         amount of any mark-to-market gain, and reduced by the amount of any
         mark-to-market deductions, included in your income. If you have made
         this mark-to-market election with respect to the CliniChem Class A
         common shares, and (1) the mark-to-market election has been in effect
         for all taxable years in your holding period for the CliniChem Class A
         common shares or (2) the taxable year of the purchase of your shares by
         BioChem is not the first taxable year for which your mark-to-market
         election is effective or (3) prior to your mark-to-market election, you
         had a qualified electing fund election in effect as to CliniChem for
         each of CliniChem's taxable years that is included in your holding
         period for the CliniChem Class A common shares, then any gain that your
         recognize on the purchase of your shares by BioChem will not be subject
         to the unfavorable tax and interest-charge regime described above. In
         such a case, any gain that you recognize on the purchase of your shares
         will be treated as ordinary income, and any loss will be treated as
         ordinary loss to the extent of net mark-to-market gains previously
         included in income.

         CANADIAN TAX CONSEQUENCES

         The following is a summary of the principal Canadian federal income tax
         considerations generally applicable to holders of CliniChem Class A
         common shares in respect of the sale of such Class A common shares to
         BioChem in exchange for cash. This summary is not applicable to holders
         who are "financial institutions" for the purposes of the mark-to-market
         rules contained in the Income Tax Act (Canada) (the "Tax Act") or to
         holders who are "specified financial institutions" for the purposes of
         the Tax Act.

         This summary is based upon the current provisions of the Tax Act, the
         regulations thereunder (the "Regulations"), and counsel's understanding
         of the current published administrative practices of the Canada
         Customs and Revenue Agency. This summary also takes into account
         specific proposals to amend the Tax Act and Regulations publicly
         announced by or on behalf of the Minister of Finance (Canada) prior to
         the date hereof (the "Proposed Amendments") and assumes that all
         Proposed Amendments will be enacted substantially as proposed. However,
         no assurances can be given that the Proposed Amendments will be enacted
         as proposed, or at all. This summary does not otherwise take into
         account or anticipate any changes in the law, whether by way of
         legislative, judicial or governmental action or decision, nor does it
         take into account provincial, territorial or foreign tax legislation or
         considerations.



                                       19
<PAGE>   20
         Resident Shareholders

         The following applies only to holders who, for the purposes of the Tax
         Act, are resident or deemed to be resident in Canada, hold their Class
         A common shares as capital property and deal at arm's length with
         BioChem and CliniChem (a "Resident Shareholder"). CliniChem Class A
         common shares will generally be considered to be capital property to a
         holder unless the holder either holds such Class A common shares in the
         course of carrying on a business or acquired such Class A common shares
         in a transaction or transactions considered to be an adventure in the
         nature of trade. Certain Canadian resident holders whose CliniChem
         Class A common shares might not otherwise be considered capital
         property may be entitled to have them treated as capital property by
         making the election permitted by subsection 39(4) of the Tax Act.

         A Resident Shareholder who is required to dispose of CliniChem Class A
         common shares to BioChem in exchange for cash will realize a capital
         gain (or a capital loss) to the extent that the price paid by BioChem
         for such Class A common shares, net of any reasonable costs of
         disposition, exceeds (or is less than) the adjusted cost base (for the
         purposes of the Tax Act) to the Resident Shareholder of such CliniChem
         Class A common shares. If a holder received a CliniChem Class A common
         share in the June 1998 distribution, the holder's initial adjusted cost
         base in such share was equal to the fair market value of such share at
         the date of distribution (Cdn $8.82 or US $6.00).

         A Resident Shareholder is required, under Proposed Amendments, to
         include in income one half of the amount of any resulting capital gain
         as a "taxable capital gain" for the taxation year in which such
         Resident Shareholder's CliniChem Class A common shares are purchased
         and paid for by BioChem and will generally be entitled to deduct one
         half of the amount of any resulting capital loss as an "allowable
         capital loss" against taxable capital gains realized in such taxation
         year. Any excess of allowable capital losses over taxable capital gains
         of the holder for the year of disposition may be carried back up to
         three taxation years or forward indefinitely and deducted against net
         taxable capital gains in those other years to the extent and under the
         circumstances described in the Tax Act and Proposed Amendments.

         A capital loss otherwise arising on the disposition of CliniChem Class
         A common shares by a Resident Shareholder may in certain circumstances
         be reduced by the amount of any dividends, including deemed dividends,
         which have been received by a Resident Shareholder on such Class A
         common shares. A Resident Shareholder that is a "Canadian-controlled
         private corporation" (as defined for the purposes of the Tax Act) may
         be subject, in addition to tax otherwise payable under the Tax Act, to
         a refundable tax of 6 2/3% on any taxable capital gains arising on the
         disposition of CliniChem Class A common shares. Capital gains realized
         by an individual or a trust, other than certain specified trusts, may
         give rise to alternative minimum tax under the Tax Act. Resident
         Shareholders should consult their own tax advisors with respect to the
         alternative minimum tax provisions.

         Non-Resident Shareholders

         The following applies to holders of CliniChem Class A common shares
         who, at all relevant times, are neither resident, nor deemed to be
         resident, of Canada for the purposes of the Tax Act and any applicable
         tax treaty or convention, who hold their Class A common shares as
         capital property, who deal at arm's length with BioChem and


                                       20
<PAGE>   21
         CliniChem, who do not use or hold, and are not deemed to use or hold,
         the Class A common shares in carrying on a business in Canada and who
         are not non-resident insurers (a "Non-Resident Holder").

         A Non-Resident Holder of CliniChem Class A common shares that are not
         taxable Canadian property will not be subject to tax under the Tax Act
         on the disposition of such Class A common shares to BioChem. Generally,
         CliniChem Class A common shares will not be taxable Canadian property
         to a Non-Resident Holder at a particular time provided that such shares
         are listed on a prescribed stock exchange (which currently includes The
         Toronto Stock Exchange and the Nasdaq National Market) at that time and
         at no time during the five-year period immediately preceding the
         disposition of CliniChem Class A common shares did the holder,  either
         alone or with persons with whom the holder does not deal at arm's
         length, own or have an interest in or an option to acquire shares in
         respect of 25% or more of the issued shares of any class or series of
         CliniChem.

         If CliniChem Class A common shares constitute or are deemed to
         constitute taxable Canadian property to a particular Non-Resident
         Holder, on the disposition thereof to BioChem, such holder will realize
         a capital gain (or capital loss) generally computed in the manner
         described above under "Resident Shareholders". Any such capital gain
         may be exempt from tax under the terms of an income tax treaty or
         convention between Canada and the country in which the Non-Resident
         Holder resides.

         If the CliniChem Class A common shares constitute or are deemed to
         constitute taxable Canadian property and the disposition of such Class
         A common shares by a Non-Resident Holder gives rise to a capital gain
         which is not exempt from Canadian tax under the terms of an applicable
         income tax treaty or convention, the tax consequences as described
         above under "Resident Shareholders" will generally apply. NON-RESIDENT
         HOLDERS WHOSE CLASS A COMMON SHARES ARE TAXABLE CANADIAN PROPERTY
         SHOULD CONSULT THEIR OWN TAX ADVISORS FOR ADVICE HAVING REGARD TO THEIR
         PARTICULAR CIRCUMSTANCES.


ITEM 8.  FAIRNESS OF THE TRANSACTION.

(a)      BioChem reasonably believes that the transaction is fair to all holders
         of Class A common shares, other than BioChem or any affiliate of
         BioChem.  BioChem, as the holder of all the CliniChem Class B common
         shares, is entitled to elect one of CliniChem's directors. Dr.
         Francesco Bellini, Chairman of the Board and Chief Executive Officer
         of BioChem, was elected by BioChem to CliniChem's board of directors.
         Therefore, Dr. Bellini abstained from all the voting by BioChem's
         board of directors on matters related to BioChem's exercise of its
         purchase option.

(b)      The material factors upon which BioChem bases its belief stated in Item
         8(a) above are as follows:

                  BioChem's purchase option was disclosed to the holders of
                  Class A common shares at the time the Class A common shares
                  were distributed to the holders of BioChem common shares as a
                  dividend-in-kind, and the prospectus distributed at the time
                  of the distribution described the purchase option and its
                  mechanics. BioChem's purchase option is also set forth in
                  CliniChem's amended Articles of Incorporation, which were
                  publicly filed with the Securities and Exchange


                                       21
<PAGE>   22
                  Commission before the distribution of the CliniChem Class A
                  common shares. Pursuant to CliniChem's amended Articles of
                  Incorporation, the share certificates for the Class A common
                  shares were legended to provide notice of the purchase option
                  to holders of Class A common shares. Furthermore, each Annual
                  Report on Form 20-F filed by CliniChem since the distribution
                  has also advised holders of the Class A common shares of the
                  purchase option. As a result, every holder of Class A common
                  shares received substantial notice of the terms of the
                  purchase option prior to making any investment decision with
                  respect to the Class A common shares, and subsequently.

                  BioChem's planned exercise of the purchase option will be
                  consistent with the terms set forth in CliniChem's amended
                  Articles of Incorporation. As required by CliniChem's amended
                  Articles of Incorporation, the notice that BioChem will send
                  to the holders of the Class A common shares upon the exercise
                  of the purchase option will provide all of the relevant
                  information relating to its exercise of the purchase option.

                  The holders of Class A common shares have no choice under the
                  terms of the Purchase Option as to whether to accept or reject
                  BioChem's acquisition, because the terms specifically provide
                  for the automatic transfer of title of the Class A common
                  shares to BioChem on the closing date without any action on
                  the part of the holder of Class A common shares.

                  In accordance with the terms of the purchase option, all
                  holders of Class A common shares excluding BioChem, regardless
                  whether they are affiliates of CliniChem or BioChem, will
                  receive the same consideration from BioChem per Class A common
                  share.

                  BioChem reasonably believes that the transaction described in
                  this Transaction Statement is fair to all holders of Class A
                  common stock, other than BioChem of affiliates of BioChem.
                  The possibility of the exercise of the purchase option was
                  contemplated and disclosed at the time that the Class A
                  common share were distributed as a dividend in kind to
                  holders of BioChem common shares and the purchase option is
                  an integral part of the terms of the Class A common stock. In
                  making its determination of fairness to holders of Class
                  A,BioChem common shares, other than BioChem or affiliates of
                  BioChem, BioChem did not give consideration to any of the
                  following factors: the current market price of the Class A
                  common shares, the historical market prices of the Class A
                  common shares, the net book value of CliniChem, the going
                  concern value of CliniChem, the liquidation value of
                  CliniChem, the purchases prices paid by BioChem with respect
                  to the previous purchases of CliniChem Class A common stock
                  that are described in Section Item 2(f) of the this
                  Transaction Statement or any report, opinion or appraisal or
                  firm offers of which CliniChem or BioChem is aware made by a
                  person or entity which is not an affiliate of CliniChem or
                  BioChem, during the past two years for (a) the merger or
                  consolidation of CliniChem with or into another company, or
                  vice versa, (b) the sale or other transfer or all or any
                  substantial part of the assets of CliniChem, or (c) a
                  purchase of CliniChem's securities that would enable the
                  resulting holder to exercise control of CliniChem.

(c)      CliniChem's amended Articles of Incorporation do not require any
         approval of holders of the Class A common shares for the exercise of
         the purchase option.

(d)      After making reasonable inquiry, BioChem believes that no directors of
         CliniChem have retained an unaffiliated representative to act solely on
         behalf of any security holders of CliniChem as no action is required by
         either CliniChem's directors or CliniChem's security holders to effect
         the purchase option.

(e)      Not applicable.

(f)      Not applicable.

ITEM 9.  REPORTS, OPINIONS, APPRAISALS AND NEGOTIATIONS.

(a)      Neither BioChem, nor to the best of BioChem's knowledge after
         reasonable inquiry of Clinichem, CliniChem or its affiliates, has
         received any report, opinion or appraisal from an outside party that
         is materially related to the transaction described in this
         Transaction Statement.

(b)      Not applicable.

(c)      Not applicable.




                                       22
<PAGE>   23
ITEM 10.  SOURCE AND AMOUNT OF FUNDS OR OTHER CONSIDERATION.

(a)      BioChem intends to pay the exercise price for the purchase option in
         cash from its working capital.

(b)      None.

(c)      BioChem's estimated expenses for the exercise of the purchase option
         include:


<TABLE>
<S>                                                             <C>
                Filing fees                                         US $5,197
                Printer fees                                       US $35,000
                Accounting fees                                     US $5,000
                Legal fees                                        US $100,000
</TABLE>

         CliniChem will not be responsible for any of the fees incurred by
         BioChem in connection with the exercise of the purchase option.

(d)      Not applicable.


ITEM 11. INTEREST IN SECURITIES OF THE SUBJECT COMPANY.

(a)      As of October 26, 2000, BioChem beneficially owned 559,674 Class A
         common shares.

         As of October 26, 2000, to BioChem's knowledge after reasonable
         inquiry, no shares of Class A common shares are beneficially owned by
         BioChem's officers and directors except as set forth below.


<TABLE>
<CAPTION>
                                                                   Percentage of Class A
                                                                       Common Shares
                                          Total Share Ownership         Outstanding
                                          ---------------------         -----------
<S>                                       <C>                      <C>
              Frederick J. Andrew                  17,458                        *
              Francesco Bellini                   133,090                       5%
              Gervais Dionne                       21,944                        *
              Jean-Louis Fontaine                   6,844                        *
              James A. Grant                           50                        *
              Roderick L. Henry                       100                        *
              Francois Legault                      2,082                        *
              Guy Lord                              4,000                        *
              Michel Perron                         1,550                        *
</TABLE>

              * = less than 1%


(b)      None.



                                       23
<PAGE>   24
ITEM 12. THE SOLICITATION OR RECOMMENDATION.

(d)      Not applicable.

(e)      Not applicable.


ITEM 13. FINANCIAL STATEMENTS.

(a)      CliniChem's financial information is incorporated herein by reference
         from CliniChem's Annual Report on Form 20-F for the year ended December
         31, 1999 (Commission File No. 000-24345). CliniChem had no material
         fixed charges for its two most recent fiscal years. Book value per
         share of CliniChem Class A common shares was Cdn $21.55 per share at
         December 31, 1999.

(b)      Not applicable.

ITEM 14. PERSONS/ASSETS, RETAINED, EMPLOYED, COMPENSATED OR USED.

(a)      Not applicable.

(b)      Not applicable.


ITEM 15. ADDITIONAL INFORMATION.

(a)      BioChem does not believe that any additional information is necessary
         to make the required disclosures in this Transaction Statement, in
         light of the circumstances under which they are made, not materially
         misleading.


ITEM 16. EXHIBITS.

99(a)(1)          Form of notice of BioChem Pharma Inc. of its Exercise of
                  Option to Purchase All Class A Common Shares of CliniChem
                  Development Inc.

99(d)(1)          Amended Articles of Incorporation of CliniChem Development
                  Inc., incorporated by reference to Exhibit 3.1 to Joint
                  CliniChem Form F-1 (Registration No. 333-45871)/BioChem Form
                  F-3 (Registration No. 333-48521)



                                       24
<PAGE>   25
                                    SIGNATURE

         After due inquiry and to the best of my knowledge and belief, I certify
that the information set forth in this statement is true, complete and correct.

                                         Guy Lord
                                         Senior Vice President,
                                         Corporate Affairs and Secretary
                                         BioChem Pharma Inc.

                                         /s/ Guy Lord
                                         --------------------------------------
                                                  (Signature)



                                         Date: November 20, 2000






                                       25


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