BIOCHEM PHARMA INC
SC 13E3/A, EX-99.A.1, 2000-11-21
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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<PAGE>   1
                                                                Exhibit 99(a)(1)

                               BIOCHEM PHARMA INC.

                       EXERCISE OF OPTION TO PURCHASE ALL
                            CLASS A COMMON SHARES OF
                           CLINICHEM DEVELOPMENT INC.

                           --------------------------

                            NOTICE TO SHAREHOLDERS OF
                           CLINICHEM DEVELOPMENT INC.

                           ---------------------------

         This information is disseminated pursuant to Rule 13e-3 of the United
States Securities Exchange Act of 1934, as amended.


         THIS TRANSACTION HAS NOT BEEN APPROVED OR DISAPPROVED BY THE SECURITIES
         AND EXCHANGE COMMISSION NOR HAS THE COMMISSION PASSED UPON THE FAIRNESS
         OR MERITS OF SUCH TRANSACTION NOR UPON THE ACCURACY OR ADEQUACY OF THE
         INFORMATION CONTAINED IN THIS DOCUMENT. ANY REPRESENTATION TO THE
         CONTRARY IS UNLAWFUL.
<PAGE>   2
                                SUMMARY OF TERMS

         BioChem Pharma Inc. wishes to advise holders of the Class A common
shares of CliniChem Development Inc. that, on October 26, 2000, BioChem
exercised its option to purchase all of the issued and outstanding shares of
Class A common shares of CliniChem as provided in Section 3.7 of CliniChem's
amended Articles of Incorporation.

         The material terms of BioChem's exercise of its option to purchase the
CliniChem Class A common shares are as follows:

         -        CLOSING DATE: The closing date for this purchase will be on
                  December 15, 2000, subject to adjustment according to Section
                  3.9 of CliniChem's amended Articles of Incorporation.

         -        EXERCISE PRICE: The exercise price for the purchase option,
                  which was determined according to Section 3.8 of CliniChem's
                  amended Articles of Incorporation, will be Cdn $18.43 per
                  outstanding Class A common share, for an aggregate exercise
                  price of Cdn $50,000,000.

         -        METHOD OF PAYMENT: BioChem will pay the exercise price for the
                  purchase option in cash.

         -        PAYMENT OF THE EXCERCISE PRICE: In accordance with CliniChem's
                  amended Articles of Incorporation, on or before the closing
                  date, BioChem will deposit approximately Cdn $39,690,590 with
                  General Trust of Canada. BioChem will instruct General Trust
                  of Canada to distribute the exercise price pro rata to the
                  holders of CliniChem Class A common shares, other than
                  Biochem, as of the close of business on December 15, 2000.
                  AFTER BIOCHEM COMPLIES WITH THESE CONDITIONS, OWNERSHIP
                  OF ALL CLINICHEM CLASS A COMMON SHARES NOT ALREADY OWNED BY
                  BIOCHEM WILL AUTOMATICALLY TRANSFER TO BIOCHEM ON DECEMBER
                  15, 2000. If you physically hold your Class A common share
                  certificates, you must submit your certificates to General
                  Trust of Canada (at the addresses set forth in the
                  accompanying letters of transmittal) in order to receive the
                  pro rata exercise price. If you hold your Class A common
                  shares in a brokerage account, your broker will automatically
                  credit your account with the pro rata exercise price.

         -        FURTHER INFORMATION: You should direct questions related to
                  this notice of exercise to BioChem's Investor Relations
                  Department at (450) 978-7970.

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<PAGE>   3
NATURE OF DISCLOSURE

         BioChem Pharma Inc. is providing this information to the shareholders
of CliniChem Development Inc. in compliance with Rule 13e-3 of the United States
Securities and Exchange Act of 1934, as amended. Notwithstanding the provision
of this information, BioChem disclaims application of Rule 13e-3 of the
Securities and Exchange Act of 1934 to the transaction described in this notice.

SPECIAL FACTORS

         Purpose

         The purpose of this transaction is to regain control over research and
development activities conducted by and on behalf of CliniChem and to avoid the
administrative costs relating to the operation of CliniChem. BioChem believes
that it is in the best interests of BioChem and its stockholders to exercise the
purchase option at this time.

         Because BioChem is exercising a previously granted right, no
alternatives to the exercise of the purchase option were considered.

         The transaction is structured pursuant to the terms of the previously
granted purchase option as set forth in CliniChem's amended Articles of
Incorporation. BioChem is undertaking the transaction at this time because
CliniChem's funding is expected to run out before the end of calendar year 2000,
and BioChem does not wish to provide additional operating funds to CliniChem.
Therefore, BioChem determined that the exercise of the purchase option at this
time was in the best interests of BioChem and its shareholders.

         Consequences

         Following BioChem's purchase of all of the outstanding Class A common
shares, CliniChem will be amalgamated with BioChem. BioChem anticipates
de-listing CliniChem from the Nasdaq National Market and The Toronto Stock
Exchange, filing a Form 15 with the Securities and Exchange Commission to
suspend CliniChem's reporting requirements under the Securities Exchange Act of
1934, and taking the required steps to revoke its status as a reporting issuer
in Canada. BioChem also intends to replace CliniChem's board of directors with
BioChem employees.

         Because CliniChem will be amalgamated with BioChem, BioChem will
directly own all of the assets of CliniChem upon completion of the amalgamation.

         The transaction will cause each holder of CliniChem Class A common
shares to dispose of his or her Class A common shares for consideration equal to
that shareholder's pro rata share of the exercise price stated above.

         Tax Considerations

         THE FOLLOWING DISCUSSION IS OF A GENERAL NATURE ONLY AND IS NOT
INTENDED TO BE, NOR SHOULD IT BE CONSTRUED TO BE, LEGAL OR TAX ADVICE TO ANY
PARTICULAR HOLDER OF CLINICHEM CLASS A COMMON SHARES. HOLDERS ARE ADVISED AND
EXPECTED TO CONSULT WITH THEIR OWN TAX ADVISORS FOR ADVICE REGARDING THE INCOME
TAX CONSEQUENCES TO THEM OF DISPOSING OF THEIR CLINICHEM CLASS A COMMON SHARES
TO BIOCHEM IN EXCHANGE FOR CASH, HAVING REGARD TO THEIR OWN PARTICULAR
CIRCUMSTANCES AND ANY OTHER CONSEQUENCES TO THEM OF SUCH TRANSACTION UNDER
FEDERAL, PROVINCIAL, STATE, LOCAL AND FOREIGN TAX LAWS.

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<PAGE>   4
UNITED STATES FEDERAL INCOME TAX CONSEQUENCES

         The following is a summary of the material United States federal income
tax considerations to a United States holder arising from the purchase by
BioChem of the CliniChem Class A common shares. A United States holder is a
beneficial owner of CliniChem Class A common shares that is:

         -        an individual citizen or resident of the United States;

         -        a corporation created or organized in or under the laws of the
                  United States or any of its political subdivisions; or

         -        an estate or trust the income of which is subject to United
                  States federal income taxation regardless of its source.

         This summary deals only with a United States holder that holds
CliniChem Class A common shares as a capital asset and does not address tax
considerations applicable to United States holders that may be subject to
special tax rules, such as:

         -        dealers or traders in securities or currencies;

         -        financial institutions or other United States holders that
                  treat income in respect of CliniChem Class A common shares as
                  financial services income;

         -        insurance companies;

         -        regulated investment companies;

         -        tax-exempt entities;

         -        United States holders that acquired CliniChem Class A common
                  shares upon the exercise of an employee stock option or
                  otherwise in connection with the performance of services;

         -        United States holders that hold CliniChem Class A common
                  shares as a part of a straddle or conversion transaction or
                  other arrangement involving more than one position;

         -        United States holders that own, or are deemed for United
                  States tax purposes to own, ten percent or more of the total
                  combined voting power of all classes of the voting stock of
                  CliniChem;

         -        United States holders that have a principal place of business
                  or "tax home" outside the United States; or

         -        United States holders whose "functional currency" is not the
                  United States dollar.

         This summary is based upon the provisions of the United States Internal
Revenue Code of 1986, as amended, and regulations, rulings and judicial
decisions as of the date of this notice; any such authority may be repealed,
revoked or modified, perhaps with retroactive effect, so as to result in federal
income tax consequences different from those discussed below. This summary has
no binding effect or official status of any kind; we cannot assure you that the
conclusions reached below would be sustained by a

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<PAGE>   5
court if challenged by the Internal Revenue Service (the "Service"). We will not
seek a ruling from the Service with respect to any aspect of the tax
considerations described below.

         Because United States tax consequences may differ from one holder to
the next, this summary does not purport to deal with all of the federal income
tax considerations that might be relevant to you in light of your personal
investment circumstances or status. In addition, this summary does not address
the application of other United States taxes, such as the federal estate tax or
alternative minimum tax, or state or local tax laws. Accordingly, you are
advised to consult your own tax advisor in determining the specific tax
consequences to you of BioChem's purchase of your CliniChem Class A common
shares, including the application to your particular situation of the tax
considerations discussed below, as well as the application of state, local or
other tax laws. The statements of United States tax law set out below are based
on the laws and interpretations in force as of the date of this notice, and are
subject to any changes occurring after that date.

         Sale of CliniChem Class A Common Shares

         The receipt of cash in exchange for CliniChem Class A common shares
will be treated as a taxable transaction for United States federal income tax
purposes. Accordingly, subject to the discussion below of the passive foreign
investment company rules, you will recognize a gain or loss in an amount equal
to the difference between the amount of cash that you receive, translated from
Canadian dollars to United States dollars by reference to the spot currency
exchange rate on the closing date, and the adjusted tax basis in your hands of
the CliniChem Class A common shares surrendered in exchange therefor. Subject to
the discussion below of the passive foreign investment company rules, the gain
or loss that you recognize will be a capital gain or loss, and will be a
long-term capital gain or loss if you have held the CliniChem Class A common
shares for more than one year. You will recognize separate foreign currency gain
or loss only to the extent that gain or loss arises on the actual disposition of
Canadian dollars received. Any foreign currency gain or loss generally will be
treated as ordinary income or loss.

         If you received CliniChem Class A common shares in the June 1998
distribution by BioChem of such shares, then your initial tax basis in the
CliniChem Class A common shares was equal to the fair market value of those
shares on the date of the distribution (US $6.00 or Cdn $8.82). In other cases,
your initial tax basis in CliniChem Class A common shares generally will be
equal to the cost to you of those shares. Under the passive foreign investment
company rules discussed below, if you acquired CliniChem Class A common shares
from a decedent, then, in some circumstances, your initial tax basis in those
shares will be equal to the lower of their fair market value and the basis of
those shares in the hands of the decedent.

         Gain realized by a United States holder on the purchase of CliniChem
Class A common shares by BioChem generally will be treated as United States
source gain, and loss realized by a United States holder on the purchase
generally will be treated as United States source loss, for United States
foreign tax credit purposes.

         Passive Foreign Investment Company Considerations

         IN GENERAL. A special and adverse set of United States tax rules
applies to a United States holder that holds an interest in a passive foreign
investment company. In general, a passive foreign investment company is any
foreign corporation, if (1) 75 percent or more of the gross income of the
corporation for the taxable year is passive income or (2) the average percentage
of assets held by the corporation during the taxable year that produce passive
income or that are held for the production of passive income is at least 50
percent. Because essentially all of the income derived by CliniChem since its
formation has been interest income, which is treated as passive income for
passive foreign investment company purposes, we

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believe that CliniChem will be treated as a passive foreign investment company
for its current taxable year and has been so treated for all of its prior
taxable years.

         Because CliniChem is and has been treated as a passive foreign
investment company, if you are not fully subject either to the qualified
electing fund rules described below or to the mark-to-market rules described
below, then you will be subject to a special and adverse tax and interest-charge
regime with respect to any gain that you recognize in the purchase of your
CliniChem Class A common shares by BioChem. In particular, (1) you will be
required to allocate that gain ratably to each day during your holding period
for the CliniChem Class A common shares, (2) you will be required to include in
income as ordinary income the portion of the gain that is allocated to your
current taxable year and (3) you will be taxable at the highest rate of taxation
applicable to ordinary income on the portion of the gain that is allocated to
prior taxable years, without regard to your other items of income and loss for
such prior taxable years (deferred tax). The deferred tax for each prior year
will be increased by an interest charge for the period from the due date for tax
returns for the prior year to the due date for tax returns for the current
taxable year (without regard to extensions), computed at the rates that apply to
underpayments of tax; the interest charge generally will not be deductible by an
individual taxpayer.

         QUALIFIED ELECTING FUND ELECTION. You may be able to avoid or mitigate
the effect of the unfavorable tax and interest-charge regime described above if
you make or have made a qualified electing fund election with respect to
CliniChem. A qualified electing fund election effectively requires you to
include in income currently your pro rata share of the ordinary earnings and net
capital gain of CliniChem, without regard to the amount of any distributions
made by CliniChem. Your tax basis in the CliniChem shares is increased by the
amount that is included in your income pursuant to the qualified electing fund
election.

         In general, a qualified electing fund election must be made by the due
date, taking into account extensions, for the filing of your income tax return
for your first taxable year to which the qualified electing fund election will
apply. The effect of the qualified electing fund election is to treat CliniChem
as a qualified electing fund for each of its taxable years ending with or within
a taxable year of yours for which the qualified electing fund election is
effective. If you have had a qualified electing fund election in effect as to
CliniChem for each of CliniChem's taxable years that is included in your holding
period for the CliniChem Class A common shares, then you will not be subject to
the adverse tax and interest-charge regime described above, and any gain that
you recognize on the purchase of your shares by BioChem will be treated as
capital gain under the non-passive foreign investment company rules described
above. If you make or have made a qualified electing fund election for
CliniChem, but that election has not been in effect for each of CliniChem's
taxable years that is included in your holding period for the CliniChem Class A
common shares, then the adverse tax and interest-charge regime described above
will apply, notwithstanding your qualified electing fund election, to gain that
you recognize on the purchase of your shares by BioChem, unless you make or have
made a so-called "purging" election to recognize gain as if you sold and
reacquired your CliniChem Class A common shares as of the first day of
CliniChem's first taxable year to which your qualified electing fund election
applies (the deemed sale date). If you make or have made the purging election,
then any gain that you recognize on the deemed sale, based on the fair market
value of the CliniChem Class A common shares on the deemed sale date, will be
subject to the tax and interest-charge regime, but your CliniChem Class A common
shares thereafter will be fully subject to the qualified electing fund
provisions. You may make the purging election in an original or amended return
for the taxable year that includes the deemed sale date. You are urged to
consult your own tax advisor as to the advisability and effects of making a
qualified electing fund election or a purging election.

         MARK-TO-MARKET ELECTION. We believe that the CliniChem Class A common
shares should be treated as "marketable" stock, as defined in applicable
Treasury regulations, for each calendar year since

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the distribution. As a consequence, you may be able to avoid the unfavorable tax
and interest-charge regime described above if you have elected, under Section
1296 of the Internal Revenue Code, to mark the CliniChem shares to market as of
the close of each taxable year. A mark-to-market election requires you to
include in income each year as ordinary income an amount equal to the increase
in value of the CliniChem Class A common shares for that year, regardless of
whether you actually sell the CliniChem shares. You generally are allowed a
deduction for the decrease in value of the CliniChem Class A common shares for
the taxable year, to the extent of the amount of gain previously included in
income under the mark-to-market rules, reduced by prior deductions under the
mark-to-market rules. The tax basis of the CliniChem Class A common shares in
your hands is increased by the amount of any mark-to-market gain, and reduced by
the amount of any mark-to-market deductions, included in your income. If you
have made this mark-to-market election with respect to the CliniChem Class A
common shares, and (1) the mark-to-market election has been in effect for all
taxable years in your holding period for the CliniChem Class A common shares or
(2) the taxable year of the purchase of your shares by BioChem is not the first
taxable year for which your mark-to-market election is effective or (3) prior to
your mark-to-market election, you had a qualified electing fund election in
effect as to CliniChem for each of CliniChem's taxable years that is included in
your holding period for the CliniChem Class A common shares, then any gain that
you recognize on the purchase of your shares by BioChem will not be subject to
the unfavorable tax and interest-charge regime described above. In such a case,
any gain that you recognize on the purchase of your shares will be treated as
ordinary income, and any loss will be treated as ordinary loss to the extent of
net mark-to-market gains previously included in income.

CANADIAN TAX CONSEQUENCES

         The following is a summary of the principal Canadian federal income tax
considerations generally applicable to holders of CliniChem Class A common
shares in respect of the sale of such Class A common shares to BioChem in
exchange for cash. This summary is not applicable to holders who are "financial
institutions" for the purposes of the mark-to-market rules contained in the
Income Tax Act (Canada) (the "Tax Act") or to holders who are "specified
financial institutions" for the purposes of the Tax Act.

         This summary is based upon the current provisions of the Tax Act, the
regulations thereunder (the "Regulations"), and counsel's understanding of the
current published administrative practices of the Canada Customs and Revenue
Agency. This summary also takes into account specific proposals to amend the Tax
Act and Regulations publicly announced by or on behalf of the Minister of
Finance (Canada) prior to the date hereof (the "Proposed Amendments") and
assumes that all Proposed Amendments will be enacted substantially as proposed.
However, no assurances can be given that the Proposed Amendments will be enacted
as proposed, or at all. This summary does not otherwise take into account or
anticipate any changes in the law, whether by way of legislative, judicial or
governmental action or decision, nor does it take into account provincial,
territorial or foreign tax legislation or considerations.

         Resident Shareholders

         The following applies only to holders who, for the purposes of the Tax
Act, are resident or deemed to be resident in Canada, hold their Class A common
shares as capital property and deal at arm's length with BioChem and CliniChem
(a "Resident Shareholder"). CliniChem Class A common shares will generally be
considered to be capital property to a holder unless the holder either holds
such Class A common shares in the course of carrying on a business or acquired
such Class A common shares in a transaction or transactions considered to be an
adventure in the nature of trade. Certain Canadian resident holders whose Class
A common shares might not otherwise be considered capital property may be

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<PAGE>   8
entitled to have them treated as capital property by making the election
permitted by subsection 39(4) of the Tax Act.

         A Resident Shareholder who is required to dispose of CliniChem Class A
common shares to BioChem in exchange for cash will realize a capital gain (or a
capital loss) to the extent that the price paid by BioChem for such Class A
common shares, net of any reasonable costs of disposition, exceeds (or is less
than) the adjusted cost base (for the purposes of the Tax Act) to the Resident
Shareholder of such Class A common shares. If a holder received a CliniChem
Class A common share in the June 1998 distribution, the holder's initial
adjusted cost base in such share was equal to the fair market value of such
share at the date of distribution (Cdn $8.82 or US $6.00).

         A Resident Shareholder is required, under Proposed Amendments, to
include in income one half of the amount of any resulting capital gain as a
"taxable capital gain" for the taxation year in which such Resident
Shareholder's Class A common shares are purchased and paid for by BioChem and
will generally be entitled to deduct one half of the amount of any resulting
capital loss as an "allowable capital loss" against taxable capital gains
realized in such taxation year. Any excess of allowable capital losses over
taxable capital gains of the holder for the year of disposition may be carried
back up to three taxation years or forward indefinitely and deducted against net
taxable capital gains in those other years to the extent and under the
circumstances described in the Tax Act and Proposed Amendments.

         A capital loss otherwise arising on the disposition of CliniChem Class
A common shares by a Resident Shareholder may in certain circumstances be
reduced by the amount of any dividends, including deemed dividends, which have
been received by a Resident Shareholder on such Class A common shares. A
Resident Shareholder that is a "Canadian-controlled private corporation" (as
defined for the purposes of the Tax Act) may be subject, in addition to tax
otherwise payable under the Tax Act, to a refundable tax of 6 2/3% on any
taxable capital gains arising on the disposition of CliniChem Class A common
shares. Capital gains realized by an individual or a trust, other than certain
specified trusts, may give rise to alternative minimum tax under the Tax Act.
Resident Shareholders should consult their own tax advisors with respect to the
alternative minimum tax provisions.

         Non-Resident Shareholders

         The following applies to holders of CliniChem Class A common shares
who, at all relevant times, are neither resident, nor deemed to be resident, of
Canada for the purposes of the Tax Act and any applicable tax treaty or
convention, who hold their Class A common shares as capital property, who deal
at arm's length with BioChem and CliniChem, who do not use or hold, and are not
deemed to use or hold, the Class A common shares in carrying on a business in
Canada and who are not non-resident insurers (a "Non-Resident Holder").

         A Non-Resident Holder of CliniChem Class A common shares that are not
taxable Canadian property will not be subject to tax under the Tax Act on the
disposition of such Class A common shares to BioChem. Generally, CliniChem Class
A common shares will not be taxable Canadian property to a Non-Resident Holder
at a particular time provided that such shares are listed on a prescribed stock
exchange (which currently includes The Toronto Stock Exchange and the Nasdaq
National Market) at that time and at no time during the five-year period
immediately preceding the disposition of Class A common shares did the holder,
either alone or with persons with whom the holder does not deal at arm's length,
own or have an interest in or an option to acquire shares in respect of 25% or
more of the issued shares of any class or series of CliniChem.

         If CliniChem Class A common shares constitute or are deemed to
constitute taxable Canadian property to a particular Non-Resident Holder, on the
disposition thereof to BioChem, such holder will

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realize a capital gain (or capital loss) generally computed in the manner
described above under "Resident Shareholders". Any such capital gain may be
exempt from tax under the terms of an income tax treaty or convention between
Canada and the country in which the Non-Resident Holder resides.

         If the CliniChem Class A common shares constitute or are deemed to
constitute taxable Canadian property and the disposition of such Class A common
shares by a Non-Resident Holder gives rise to a capital gain which is not exempt
from Canadian tax under the terms of an applicable income tax treaty or
convention, the tax consequences as described above under "Resident
Shareholders" will generally apply. NON-RESIDENT HOLDERS WHOSE CLASS A COMMON
SHARES ARE TAXABLE CANADIAN PROPERTY SHOULD CONSULT THEIR OWN TAX ADVISORS FOR
ADVICE HAVING REGARD TO THEIR PARTICULAR CIRCUMSTANCES.

FAIRNESS

         BioChem reasonably believes that the transaction is fair to the holders
of CliniChem Class A common shares. BioChem, as the holder of all the CliniChem
Class B common shares, is entitled to elect one of CliniChem's directors. Dr.
Francesco Bellini, Chairman of the Board and Chief Executive Officer of BioChem,
was elected by BioChem to CliniChem's board of directors. Therefore, Dr. Bellini
abstained from all the voting by BioChem's board of directors on matters
related to BioChem's exercise of its purchase option.

         The material factors upon which BioChem bases its belief that the
transaction is fair to the holders of CliniChem Class A common shares are as
follows.

         BioChem's purchase option was disclosed to the holders of Class A
common shares at the time the Class A common shares were distributed to the
holders of BioChem common shares as a dividend-in-kind, and the prospectus
distributed at the time of the distribution described the purchase option and
its mechanics. BioChem's purchase option is also set forth in CliniChem's
amended Articles of Incorporation, which were publicly filed with the Securities
and Exchange Commission before the distribution of the Class A common shares.
Pursuant to CliniChem's amended Articles of Incorporation, the share
certificates for the Class A common shares were legended to provide notice of
the purchase option to holders of Class A common shares. Furthermore, each Form
20-F annual report filed by CliniChem since the distribution has also advised
holders of the Class A common shares of the purchase option. As a result, every
holder of Class A common shares received substantial notice of the terms of the
purchase option prior to making any investment decision with respect to the
Class A common shares, and subsequently.

         BioChem's planned exercise of the purchase option will be consistent
with the terms set forth in CliniChem's amended Articles of Incorporation.

         The holders of Class A common shares have no choice under the terms of
the Purchase Option as to whether to accept or reject BioChem's acquisition,
because the terms specifically provide for the automatic transfer of title of
the Class A common shares to BioChem on the closing date without any action on
the part of the holder of Class A common shares.

         In accordance with the terms of the purchase option, all holders of
Class A common shares, regardless whether they are affiliates of CliniChem or
BioChem, will receive the same consideration from BioChem per Class A common
share.

         CliniChem's amended Articles of Incorporation do not require any
approval of holders of the Class A common shares for the exercise of the
purchase option.

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<PAGE>   10
         After making reasonable inquiry, BioChem believes that no directors of
CliniChem have retained an unaffiliated representative to act solely on behalf
of any security holders of CliniChem as no action is required by either
CliniChem's directors or CliniChem's security holders to effect the purchase
option.

         Reports

         Neither BioChem, nor to the best of BioChem's knowledge after
reasonable inquiry of Clinichem, CliniChem or its affiliates, has received any
report, opinion or appraisal from an outside party, other than an opinion of
counsel, that is materially related to the transaction described in this notice.

IDENTIFICATION AND SECURITIES OF CLINICHEM

         CliniChem's principal executive office is located at 275 Armand
Frappier Boulevard, Laval, Quebec, Canada H7V 4A7. The telephone number of
CliniChem's principal executive office is (450) 681-1744.

         The exact title of the class of equity security that is the subject of
this filing is Class A common shares, no par value per share, of CliniChem. As
of October 26, 2000, there were 2,713,260 Class A common shares issued and
outstanding.

         CliniChem's Class A common shares are traded on the Nasdaq National
Market under the symbol "CCHE" and are traded in Canada on The Toronto Stock
Exchange under the symbol "BCC.A". The following table sets forth, for the
periods indicated, the range of high and low closing sales prices of the
CliniChem Class A common shares on the Montreal Exchange (CliniChem's principal
non-United States exchange until December 3, 1999), The Toronto Stock Exchange
and the Nasdaq National Market.

<TABLE>
<CAPTION>
                          The Montreal Exchange(1)      The Toronto Stock Exchange     Nasdaq National Market
                           ---------------------        --------------------------     ----------------------
                                   Cdn $                          Cdn $                         US $
      Quarter Ending        High            Low           High             Low           High          Low
      --------------        ----            ---           ----             ---           ----          ---
<S>                       <C>             <C>           <C>               <C>          <C>            <C>
         12/31/98            8.35          6.60            8.35            6.50           5.50         4.13
         03/31/99           11.00          7.05           11.00            7.00           6.91         4.50
         06/30/99           10.65          9.50           10.75            9.50           7.50         6.38
         09/30/99           11.50          9.40           11.50            9.50           8.13         6.38
         12/31/99           15.00         11.00           14.50           11.05           9.88         7.25
         03/31/00            --             --            17.00           12.50          11.88         8.75
         06/30/00            --             --            17.75           16.05          11.88        11.38
         09/30/00            --             --            18.00           15.75          12.00        10.00
</TABLE>

(1) The CliniChem Class A common shares ceased trading on the Montreal
Exchange on December 3, 1999.

         To the best of BioChem's knowledge after making a reasonable inquiry,
CliniChem has paid no dividends on its Class A common shares during the past two
years.

         Between January 28, 2000 and July 28, 2000, BioChem purchased a total
of 559,674 Class A common shares in both open market and privately negotiated
transactions. These shares represent 20.6% of the issued and outstanding Class A
common shares.

         Between January 28, 2000 and June 30, 2000, BioChem purchased a total
of 163,400 Class A common shares in open market transactions. The following
table shows the high and low prices, as well as the average price, paid by
BioChem for Class A common shares during each fiscal quarter between
January 28, 2000 and June 30, 2000.

                                       10
<PAGE>   11
<TABLE>
<CAPTION>
                    The Toronto Stock Exchange          Nasdaq National Market
                    --------------------------          ----------------------
                              Cdn$                              US$
Quarter Ending      High      Low      Average        High      Low      Average
--------------      ----      ---      -------        ----      ---      -------
<S>                <C>       <C>        <C>          <C>        <C>      <C>
03/31/00           16.75     16.00      16.67        11.625    11.625    11.625
06/30/00           17.25     16.50      16.86        11.75     11.625    11.64
</TABLE>

         In addition, in a private transaction dated July 28, 2000, BioChem
purchased 396,274 Class A common shares from Glaxo Wellcome Inc. at a price per
share of US$9.63.

IDENTIFICATION OF BIOCHEM PHARMA INC.

         BioChem's principal business address is 275 Armand Frappier Boulevard,
Laval, Quebec, Canada H7V 4A7, and its business telephone number is (450)
978-7771. BioChem is an international biopharmaceutical company organized under
the laws of Canada whose principal business is the research, development,
manufacturing and marketing of innovative products for the prevention, detection
and treatment of human diseases.

         During the past five years, BioChem has not been convicted in a
criminal proceeding and has not been a party to a civil proceeding of a judicial
or administrative body of competent jurisdiction that resulted in a judgement,
decree or final order enjoining further violations of, or prohibiting activities
subject to, federal or state securities laws or finding any violation of such
laws.

PAST CONTACTS, TRANSACTIONS, NEGOTIATIONS AND AGREEMENTS

         The nature and approximate dollar amount of all the transactions
between BioChem and CliniChem that have occurred during the past two years are
as follows:

         In June 1998, BioChem entered into a series of agreements with
CliniChem. These agreements are described below in (1) - (5).

                  (1) On June 8, 1998, BioChem made a Cdn $150 million cash
                      contribution to CliniChem's capital. The shares issued by
                      CliniChem that were held by BioChem were exchanged for
                      Class A and Class B common shares of CliniChem. On June
                      26, 1998, each holder of record of BioChem common shares
                      received one Class A common share for each 40 common
                      shares of BioChem held on June 22, 1998. The fair value of
                      the Class A common shares distributed to BioChem's
                      shareholders was approximately Cdn $24 million.

                  (2) Under the terms of a technology license agreement, BioChem
                      and its affiliates granted to CliniChem an exclusive
                      perpetual license to use BioChem and affiliate technology
                      to conduct certain research programs and related
                      activities, and to manufacture and commercialize products
                      worldwide. CliniChem pays a fee to BioChem and its
                      affiliates in exchange for the exclusive perpetual
                      technology license. The technology license fee is payable
                      monthly at a rate of Cdn $352,000 per month over a period
                      of 48 months. From June 10, 1998 to October 26, 2000,
                      CliniChem paid or incurred an aggregate amount of Cdn
                      $10,102,000 to BioChem and its affiliates pursuant to the
                      technology license contract.

                                       11
<PAGE>   12
                  (3) Under the terms of a research and development agreement,
                      BioChem conducts various research activities on behalf of
                      CliniChem. CliniChem is required under the terms of the
                      research and development agreement to use available funds,
                      as defined in the contract, to repay BioChem for its
                      research and development expenses. From June 10, 1998 to
                      October 26, 2000, CliniChem paid or incurred an aggregate
                      amount of Cdn $131,645,000 to BioChem pursuant to the
                      research and development agreement.

                  (4) Under the terms of a product option agreement, CliniChem
                      granted BioChem and certain of its affiliates an option to
                      acquire all rights to certain or all products developed by
                      CliniChem. This option is exercisable on a
                      country-by-country basis for each product developed by
                      CliniChem. From June 10, 1998 to October 26, 2000, BioChem
                      paid or incurred an aggregate amount of Cdn $19,000 to
                      CliniChem pursuant to the product option agreement.

                  (5) Under the terms of a services agreement, BioChem agreed to
                      provide CliniChem with administrative services, including
                      accounting, legal and other services for an annual fee of
                      $400,000. From June 10, 1998 to October 26, 2000,
                      CliniChem paid or incurred an aggregate amount of Cdn
                      $1,133,000 to BioChem pursuant to the services agreement.

         On July 28, 2000, BioChem purchased 396,274 Class A common shares
from Glaxo Wellcome Inc., pursuant to a privately negotiated share purchase
agreement dated July 27, 2000 between BioChem and Glaxo. At the time BioChem
purchased these Class A common shares from Glaxo. Glaxo, by virtue of the
number of Class A common shares it beneficially owned before the sale to
BioChem, may have been an affiliate of CliniChem. The aggregate price that
BioChem paid Glaxo for the shares was US $3,816,119, or US $9.63 per share.

TERMS OF THE TRANSACTION

         On January 10, 2000, BioChem disclosed in a press release that it
intended to exercise the purchase option provided by CliniChem's amended
Articles of Incorporation. The purchase option gives BioChem, as sole holder of
all of CliniChem's issued and outstanding Class B common shares, the right to
acquire all, but not less than all, of the issued and outstanding Class A
common shares. BioChem has elected to purchase the Class A common shares on
December 15, 2000 and to pay the aggregate exercise price of Cdn $50 million in
cash. The exercise price was calculated according to a predetermined formula
set out in CliniChem's amended Articles of Incorporation. As a result of
BioChem's exercise of the purchase option, each Class A common share will be
exchanged for Cdn $18.43. BioChem may extend the date on which it completes the
purchase of the issued and outstanding Class A common shares pursuant to the
purchase option by delivering a notice to CliniChem of its decision to do so,
if in its judgment an extension is necessary:

         (1)      to obtain any governmental or third party consent to purchase
                  the Class A common shares;

         (2)      to permit any necessary prospectus to be receipted or
                  registration statement or similar filing to be declared
                  effective;

         (3)      to permit the expiration prior to the date BioChem completes
                  its purchase of the issued and outstanding Class A common
                  shares, of any statutory or regulatory waiting period; or

                                       12
<PAGE>   13
         (4)      to fulfill any other applicable requirements.

         In accordance with the terms of CliniChem's amended Articles of
Incorporation, the holders of Class A common stock do not need to take any steps
to approve BioChem's exercise of the purchase option. Transfer of title of all
the issued and outstanding Class A common shares will be deemed to occur
automatically on December 15, 2000, and thereafter CliniChem will treat
BioChem as the sole holder of Class A common shares and the exercise price will
be paid to holders of Class A common shares on December 15, 2000 in accordance
with their respective interests.

PLANS OR PROPOSALS OF BIOCHEM PHARMA INC.

         Following BioChem's purchase of all of the outstanding Class A common
shares, CliniChem will be amalgamated with BioChem. BioChem anticipates
de-listing CliniChem from the Nasdaq National Market and The Toronto Stock
Exchange, filing a Form 15 with the Securities and Exchange Commission to
suspend CliniChem's reporting requirements under the Securities Exchange Act of
1934, and taking the required steps to revoke its shares as a reporting issuer
in Canada. BioChem also intends to replace CliniChem's board of directors with
BioChem's employees.

INTEREST IN SECURITIES OF CLINICHEM

         As of October 26, 2000, BioChem beneficially owned 559,674 CliniChem
Class A common shares.

         As of October 26, 2000, to BioChem's knowledge after reasonable
inquiry, no CliniChem Class A common shares are beneficially owned by BioChem's
officers and directors except as set forth below:

<TABLE>
<CAPTION>
                                                                              Percentage of Class A Common
                                                 Total Share Ownership             Shares Outstanding
                                                 ---------------------             ------------------
<S>                                              <C>                          <C>
          Frederick J. Andrew                                 17,458                       *
          Francesco Bellini                                  133,090                       5%
          Gervais Dionne                                      21,944                       *
          Jean-Louis Fontaine                                  6,844                       *
          James A. Grant                                          50                       *
          Roderick L. Henry                                      100                       *
          Francois Legault                                     2,082                       *
          Guy Lord                                             4,000                       *
          Michel Perron                                        1,550                       *

          * = less than 1%
</TABLE>

CONTRACTS, ARRANGEMENTS OR UNDERSTANDINGS WITH RESPECT TO CLINICHEM'S CLASS A
COMMON STOCK

         In January 1998, BioChem incorporated CliniChem under the Canada
Business Corporations Act to conduct research and development of potential human
therapeutic products, primarily for the treatment of cancer and HIV infection,
and vaccine products, for the prevention of certain bacterial infectious
diseases.

         CliniChem's amended Articles of Incorporation grant BioChem, as the
holder of the majority of the issued and outstanding Class B common shares, the
right to acquire all, but not less than all, of the issued and outstanding Class
A common shares and the right to appoint one of CliniChem's Directors.

                                       13
<PAGE>   14
         Pursuant to CliniChem's Amended Articles of Incorporation, purchase
option is exercisable by written notice given at any time from and after June
26, 1998 and ending on the earlier of (i) March 31, 2003 or (ii) the 90th day
after the date CliniChem provides BioChem (as the holder of the majority of the
outstanding Class B common shares) with quarterly financial statements of
CliniChem showing cash or cash equivalents of less than Cdn $5.0 million,
although BioChem may, at its election, extend such period by providing
additional funding, including through loans, for the continued conduct of any or
all of CliniChem's research (but in no event beyond March 31, 2003).

         CliniChem's Amended Articles of Incorporation provide that the amount
payable upon the exercise of the purchase option, which is referred to in this
notice as the purchase option exercise price, is the greatest of:

         (a)      25 times the aggregate of:

                  (1)      all worldwide payments made by and all worldwide
                           payments due to be made by BioChem and certain of its
                           affiliates with respect to all products for which the
                           product option (as such term is defined in
                           CliniChem's amended Articles of Incorporation) was
                           exercised for the four calendar quarters immediately
                           preceding the quarter in which the purchase option is
                           exercised; and

                  (2)      all payments that would have been made and all
                           payments due to be made by BioChem and certain of its
                           affiliates to CliniChem during the base period (as
                           such term is defined in CliniChem's amended Articles
                           of Incorporation) if the option to buy out
                           CliniChem's right to receive payments with respect to
                           acquired products (as such term is defined in
                           CliniChem's amended Articles of Incorporation) had
                           not previously been exercised for any acquired
                           product on a country-by-country or global basis
                           pursuant to the product option agreement (as such
                           term is defined in CliniChem's amended Articles of
                           Incorporation) with respect to any product;

                           less any amounts previously paid to exercise any
                           payment buy-out option for any CliniChem product (as
                           such term is defined in CliniChem's amended Articles
                           of Incorporation).

         (b)      the fair market value of 420,000 BioChem common shares as of
                  the date BioChem elects to purchase the issued and outstanding
                  Class A common shares pursuant to the purchase option;

         (c)      Cdn $175 million plus any additional funds contributed to
                  CliniChem by BioChem less the aggregate amount of all
                  technology fee payments, research and development costs and
                  services agreement payments paid or incurred by CliniChem as
                  of the date BioChem elects to purchase the issued and
                  outstanding Class A common shares pursuant to the purchase
                  option; and

         (d)      Cdn $50 million.

                                       14
<PAGE>   15
         On November 1, 2000, Clinichem delivered to Biochem a balance sheet,
together with (i) a statement and brief description of all the liabilities of
Clinichem as of the date of such balance sheet not reflected on such balance
sheet;(ii) a statement of the amount of available funds remaining as of such
date; and (iii) a statement of the total amounts paid by and due from CliniChem
pursuant to the Research and Development Agreement through such date. On
November 22, 2000, CliniChem received the determination of the final Purchase
Option Exercise Price. In accordance with the amended Articles of Incorporation
of Clinichem, BioChem is mailing this notice to each person who, at the date of
this notice is a registered holder of Class A Common Shares.

         In accordance with CliniChem's amended Articles of Incorporation, on or
before the closing date, BioChem will deposit approximately Cdn $39,390,590 with
General Trust of Canada. Biochem will irrevocably instruct General Trust of
Canada to distribute the exercise price pro rata to the holders of Clinichem
Class A common Shares as of the close of business on December 15, 2000.

         CliniChem's amended Articles of Incorporation further provide that
transfer of title of all the issued and outstanding Class A common shares will
be deemed to occur automatically on the closing date and thereafter CliniChem
will treat BioChem as the sole holder of the issued and outstanding Class A
common shares.


         On January 10, 2000, BioChem disclosed in a press release that it
intended to exercise the purchase option when CliniChem's funding ran out, which
BioChem estimates is likely to occur before the end of calendar year 2000.
BioChem has elected to purchase the shares on December 15, 2000 and to pay the
exercise price for the purchase option, which was calculated according to a
predetermined formula contained in CliniChem's amended Articles of
Incorporation, in cash.

                                       15
<PAGE>   16
OTHER PROVISIONS OF THE TRANSACTION

         No appraisal rights are afforded under either applicable law or
BioChem's notice to holders of Class A common shares of its intention to
exercise the purchase option, and neither BioChem nor CliniChem will afford such
rights. BioChem is not aware of any rights available to objecting holders of
Class A common shares under applicable law.

         BioChem is unaware, after making reasonable inquiry of CliniChem, of
any grant of access to unaffiliated security holders to the corporate files of
either CliniChem or BioChem or the appointment of counsel or appraisal services
for unaffiliated security holders at the expense of either CliniChem or BioChem.

TRANSACTION EXPENSES

         BioChem's estimated expenses for the transaction includes filing fees
of US $5,197, printer fees of approximately US $35,000, accounting fees of
approximately US $5,000 and legal fees of approximately US $100,000.
CliniChem will not be responsible for paying any of BioChem's expenses
associated with the exercise of its option to purchase all of the issued and
outstanding Class A common shares of CliniChem.

SOURCE OF TRANSACTION FUNDS

         The source of funds to pay the exercise price and the transaction
expenses is cash from BioChem's working capital.

SUMMARY OF FINANCIAL STATEMENTS

         Set forth below is a summary of CliniChem's selected consolidated
financial data, which has been excerpted or derived from the information
contained in CliniChem's Annual Report on Form 20-F for the year ended December
31, 1999. More comprehensive information is included in such reports and other
documents filed by CliniChem with the United States Securities and Exchange
Commission and Canada's Securities Commission, and the following information
should be read in conjunction with such reports and other documents and the
financial information including any related notes and Management's Discussion
and Analysis of Financial Condition and Results of Operations contained therein.

                            Statement of Income Data:
          (in thousands of Canadian dollars, except per share amounts)

<TABLE>
<CAPTION>
                                                                         Period from
                                                                          inception
                                                                       June 10, 1998
                                                                          through                  Year ended
                                                                     December 31, 1998           December 31, 1999
<S>                                                                  <C>                         <C>
Total revenues.......................................                      4,061                        5,262
Net Loss.............................................                     17,384                       67,655
Loss per share.......................................                       6.41                        24.93
Ratio of earnings to fixed charges...................                        N/A                          N/A
</TABLE>

                                       16
<PAGE>   17
                               Balance Sheet Data:
          (in millions of Canadian dollars, except per share amounts)

<TABLE>
<CAPTION>
                                                                     December 31, 1998           December 31, 1999
<S>                                                                  <C>                         <C>
Working capital......................................                     126,117                      58,462
Total Assets.........................................                     136,275                      75,367
Total stockholders' equity...........................                     126,117                      58,462
Book value per share.................................                       46.46                       21.54
</TABLE>

Note to Selected Consolidated Financial Data

(1)      CliniChem had no material fixed charges for the periods presented.


                                       17


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