CAMBRIDGE NEUROSCIENCE INC
SC 13G/A, 1999-02-12
PHARMACEUTICAL PREPARATIONS
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                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                   -----------

                                  SCHEDULE 13G
                                 (Rule 13d-102)

             INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT
          TO RULES 13d-1(b), (c), AND (d) AND AMENDMENTS THERETO FILED
                            PURSUANT TO RULE 13d-2(b)

                              (Amendment No. 1)(1)

                          Cambridge NeuroScience, Inc.
                      ------------------------------------
                                (Name of Issuer)

                                  Common Stock
                ------------------------------------------------
                         (Title of Class of Securities)

                                    132426107
                     ---------------------------------------
                                 (CUSIP Number)

                                December 31, 1998
      ---------------------------------------------------------------------
             (Date of Event Which Requires Filing of this Statement)

          Check the appropriate box to designate the rule pursuant to which this
     Schedule is filed:

                |_| Rule 13d-1(b)
                |X| Rule 13d-1(c)
                |_| Rule 13d-1(d)



- ---------------------

          (1) The remainder of this cover page shall be filled out for a
     reporting person's initial filing on this form with respect to the subject
     class of securities, and for any subsequent amendment containing
     information which would alter disclosures provided in a prior cover page.

          The information required on the remainder of this cover page shall not
     be deemed to be "filed" for the purpose of Section 18 of the Securities
     Exchange Act of 1934 or otherwise subject to the liabilities of that
     section of the Act but shall be subject to all other provisions of the Act
     (however, see the Notes).


                                Page 1 of 5 Pages
<PAGE>


- ----------------------------------                   ---------------------------
| CUSIP NO.  132426107           |        13G        |   Page  2  of  5  Pages |
|           -----------          |                   |        ---    ---       |
- ----------------------------------                   ---------------------------

|--------|---------------------------------------------------------------------|
|   1    |  NAME OF REPORTING PERSON                                           |
|        |  S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON                  |
|        |                                                                     |
|        |  Charlesbank Capital Partners, LLC                                  |
|--------|---------------------------------------------------------------------|
|   2    |  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*         (a) [ ]  |
|        |                                                            (b) [ ]  |
|        |                                                                     |
|--------|---------------------------------------------------------------------|
|   3    |  SEC USE ONLY                                                       |
|        |                                                                     |
|--------|---------------------------------------------------------------------|
|   4    |  CITIZENSHIP OR PLACE OF ORGANIZATION                               |
|        |                                                                     |
|        |  Massachusetts                                                      |
|-----------------|--------|---------------------------------------------------|
|                 |   5    |  SOLE VOTING POWER                                |
|                 |        |  1,106,033 shares                                 |
|     NUMBER OF   |--------|---------------------------------------------------|
|      SHARES     |   6    |  SHARED VOTING POWER                              |
|   BENEFICIALLY  |        |         --                                        |
|     OWNED BY    |--------|---------------------------------------------------|
|       EACH      |   7    |  SOLE DISPOSITIVE POWER                           |
|    REPORTING    |        |  1,106,033 shares                                 |
|      PERSON     |--------|---------------------------------------------------|
|       WITH      |   8    |  SHARED DISPOSITIVE POWER                         |
|                 |        |         --                                        |
|------------------------------------------------------------------------------|
|   9    |  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON       |
|        |                                                                     |
|        |  1,106,033 shares                                                   |
|--------|---------------------------------------------------------------------|
|  10    |  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN  [ ] |
|        |  SHARES*                                                            |
|        |                                                                     |
|--------|---------------------------------------------------------------------|
|  11    |  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)                  |
|        |  6.1%                                                               |
|--------|---------------------------------------------------------------------|
|  12    |  TYPE OF REPORTING PERSON*                                          |
|        |  00                                                                 |
- --------------------------------------------------------------------------------
                      *SEE INSTRUCTIONS BEFORE FILLING OUT!

                                Page 2 of 5 Pages

<PAGE>


                                  SCHEDULE 13G
                                  ------------

Item 1(a)  Name of Issuer:
                   Cambridge NeuroScience, Inc.

     1(b)  Address of Issuer's Principal Executive Offices:
                   One Kendall Square
                   Building 700
                   Cambridge, MA  02139

Item 2(a)  Name of Person Filing:
                   Charlesbank Capital Partners, LLC

     2(b)  Address of Principal Business Office or, if none, Residence:
                   600 Atlantic Avenue, 26th Floor
                   Boston, MA  02210

     2(c)  Citizenship:
                   Massachusetts

     2(d)  Title of Class of Securities:
                   Common Stock

     2(e)  CUSIP Number:
                   132426107

Item 3     This statement is filed pursuant to Rule 13d-1(c).

Item 4     Ownership:

     4(a)  Amount beneficially owned:
                   1,106,033 shares

     4(b)  Percent of Class:
                   6.1%

     4(c) Number of shares as to which such person has:

           (i)  sole power to vote or to direct the vote:
                   1,106,033 shares


                                Page 3 of 5 Pages

<PAGE>


           (ii) shared power to vote or to direct the vote:

                                ---------

          (iii) sole power to dispose or to direct the disposition of:

                                1,106,033 shares

           (iv) shared power to dispose or to direct the disposition of:

                                ---------

Item 5     Ownership of Five Percent or Less of a Class:
                   Not Applicable.

Item 6     Ownership of More than Five Percent on Behalf of Another Person:
                  Beneficial ownership of the securities was acquired by
                  Charlesbank Capital Partners, LLC ("Charlesbank") pursuant to
                  the Existing Assets Management Agreement, dated as of July 1,
                  1998, between Charlesbank, President and Fellows of Harvard
                  College ("Harvard") and certain individuals (the "Agreement").
                  Pursuant to the Agreement, Charlesbank will act as an
                  investment manager on behalf of Harvard and its affiliates in
                  connection with certain existing investments of Harvard and
                  its affiliates, including the investment in Cambridge
                  NeuroScience, Inc. disclosed herein.

Item 7     Identification and Classification of the Subsidiary which Acquired
           the Security Being Reported on by the Parent Holding Company:
                   Not Applicable.

Item 8     Identification and Classification of Members of the Group:
                   Not Applicable.

Item 9     Notice of Dissolution of Group:
                   Not Applicable.

Item 10    Certification:

           By signing below the undersigned certifies that, to the best of its
           knowledge and belief, the securities referred to above were not
           acquired and are not held for the purpose of or with the effect of
           changing or influencing the control of the issuer of the securities
           and were not acquired and are not held in connection with or as a
           participant in any transaction having that purpose or effect.



                                Page 4 of 5 Pages
<PAGE>


After reasonable inquiry and to the best of its knowledge and belief, the
undersigned certifies that the information set forth in this statement is true,
complete and correct.



                             CHARLESBANK CAPITAL PARTNERS, LLC

                             By: /s/ Tami E. Nason
                                 -----------------------------------------------
                                 Name:  Tami E. Nason
                                 Title: Vice President, Legal

February 12, 1999



                                Page 5 of 5 Pages




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