CAMBRIDGE NEUROSCIENCE INC
SC 13G/A, 1999-02-12
PHARMACEUTICAL PREPARATIONS
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                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                   -----------

                                  SCHEDULE 13G
                                 (Rule 13d-102)

             INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT
          TO RULES 13d-1(b), (c), AND (d) AND AMENDMENTS THERETO FILED
                            PURSUANT TO RULE 13d-2(b)

                              (Amendment No. 4)(1)


                          Cambridge NeuroScience, Inc.
             -------------------------------------------------------
                                (Name of Issuer)


                                  Common Stock
             -------------------------------------------------------
                         (Title of Class of Securities)


                                    132426107
             -------------------------------------------------------
                                 (CUSIP Number)


                                December 31, 1998
             -------------------------------------------------------
             (Date of Event Which Requires Filing of this Statement)


Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:

               [X]  Rule 13d-1(b)
               [ ]  Rule 13d-1(c)
               [ ]  Rule 13d-1(d)


- -----------

     (1) The remainder of this cover page shall be filled out for a reporting
person's initial filing on this form with respect to the subject class of
securities, and for any subsequent amendment containing information which would
alter disclosures provided in a prior cover page.

     The information required on the remainder of this cover page shall not be
deemed to be "filed" for the purpose of Section 18 of the Securities Exchange
Act of 1934 or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).


                               Page 1 of 5 Pages

<PAGE>


- ----------------------------------                   ---------------------------
|  CUSIP NO.  132426107          |       13G         |  Page  2   of  5  Pages |
|            -----------         |                   |       ---     ---       |
- ----------------------------------                   ---------------------------

|--------|---------------------------------------------------------------------|
|   1    |  NAME OF REPORTING PERSON                                           |
|        |  S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON                  |
|        |                                                                     |
|        |  Aeneas Venture Corporation                                         |
|--------|---------------------------------------------------------------------|
|   2    |  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*         (a) [ ]  |
|        |                                                            (b) [ ]  |
|        |                                                                     |
|--------|---------------------------------------------------------------------|
|   3    |  SEC USE ONLY                                                       |
|        |                                                                     |
|--------|---------------------------------------------------------------------|
|   4    |  CITIZENSHIP OR PLACE OF ORGANIZATION                               |
|        |                                                                     |
|        |  Delaware                                                           |
|-----------------|--------|---------------------------------------------------|
|                 |   5    |  SOLE VOTING POWER                                |
|                 |        |  1,106,033 shares                                 |
|     NUMBER OF   |--------|---------------------------------------------------|
|      SHARES     |   6    |  SHARED VOTING POWER                              |
|   BENEFICIALLY  |        |  ----                                             |
|     OWNED BY    |--------|---------------------------------------------------|
|       EACH      |   7    |  SOLE DISPOSITIVE POWER                           |
|    REPORTING    |        |  1,106,033 shares                                 |
|      PERSON     |--------|---------------------------------------------------|
|       WITH      |   8    |  SHARED DISPOSITIVE POWER                         |
|                 |        |  ----                                             |
|------------------------------------------------------------------------------|
|   9    |  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON       |
|        |                                                                     |
|        |  1,106,033 shares                                                   |
|--------|---------------------------------------------------------------------|
|  10    |  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN  [ ] |
|        |  SHARES*                                                            |
|        |                                                                     |
|--------|---------------------------------------------------------------------|
|  11    |  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)                  |
|        |  6.1%                                                               |
|--------|---------------------------------------------------------------------|
|  12    |  TYPE OF REPORTING PERSON*                                          |
|        |  CO                                                                 |
- --------------------------------------------------------------------------------
                      *SEE INSTRUCTIONS BEFORE FILLING OUT!


                               Page 2 of 5 Pages

<PAGE>


                                  SCHEDULE 13G
                                  ------------


Item 1(a)        Name of Issuer:
                             Cambridge NeuroScience, Inc.

     1(b)        Address of Issuer's Principal Executive Offices:
                             One Kendall Square
                             Building 700
                             Cambridge, MA  02139

Item 2(a)        Name of Person Filing:
                             Aeneas Venture Corporation

     2(b)        Address of Principal Business Office or, if none, Residence:
                         c/o Charlesbank Capital Partners, LLC
                             600 Atlantic Avenue, 26th Floor
                             Boston, MA  02210
             
     2(c)        Citizenship:
                             Delaware
             
     2(d)        Title of Class of Securities:
                             Common Stock
             
     2(e)        CUSIP Number:
                             132426107

Item 3           The reporting person is a wholly owned subsidiary of the
                 endowment fund of Harvard University in accordance with Rule
                 13d-1(b)(1)(ii)(F).

Item 4           Ownership:

     4(a)        Amount beneficially owned:
                             1,106,033 shares
             
     4(b)        Percent of Class:
                             6.1%

     4(c)        Number of shares as to which such person has:

                 (i)  sole power to vote or to direct the vote:
                             1,106,033 shares, subject to the terms of the
                             Existing Assets Management Agreement described more
                             fully in Item 6.


                                Page 3 of 5 Pages

<PAGE>



                 (ii) shared power to vote or to direct the vote:
                             ---------

                 (iii) sole power to dispose or to direct the disposition of: 
                             1,106,033 shares, subject to the terms of the
                             Existing Assets Management Agreement described
                             more fully in Item 6.

                 (iv) shared power to dispose or to direct the disposition of:
                             --------

Item 5           Ownership of Five Percent or Less of a Class:
                             Not Applicable.

Item 6           Ownership of More than Five Percent on Behalf of Another 
                 Person:
                             Pursuant to the Existing Assets Management
                             Agreement, dated July 1, 1998, between Charlesbank
                             Capital Partners, LLC ("Charlesbank"), President
                             and Fellows of Harvard College ("Harvard") and
                             certain individuals, Charlesbank will act as an
                             investment manager on behalf of Harvard and its
                             affiliates in connection with certain existing
                             investments of Harvard and its affiliates,
                             including the investment by Aeneas Venture
                             Corporation disclosed herein.

Item 7           Identification and Classification of the Subsidiary which 
                 Acquired the Security Being Reported on by the Parent Holding 
                 Company:
                             Not Applicable.

Item 8           Identification and Classification of Members of the Group:
                             Not Applicable.

Item 9           Notice of Dissolution of Group:
                             Not Applicable.

Item 10          Certification:

                 By signing below the undersigned certifies that, to the best of
                 its knowledge and belief, the securities referred to above were
                 acquired and are held in the ordinary course of business and
                 were not acquired and are not held for the purpose of or with
                 the effect of changing or influencing the control of the issuer
                 of the securities and were not acquired and are not held in
                 connection with or as a participant in any transaction having
                 that purpose or effect.


                                Page 4 of 5 Pages

<PAGE>



After reasonable inquiry and to the best of its knowledge and belief, the
undersigned certifies that the information set forth in this statement is true,
complete and correct.

                                                AENEAS VENTURE CORPORATION


                                                By: /s/ Tami E. Nason
                                                    ---------------------------
                                                    Name:  Tami E. Nason
                                                    Title: Authorized Signatory

February 12, 1999



                                Page 5 of 5 Pages





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