NEUREX CORP/DE
S-8, 1997-07-24
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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As filed with the Securities and Exchange Commission on July 23, 1997 
Registration No. _________________
                                          
================================================================================

                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                             REGISTRATION STATEMENT
                                       on
                                    FORM S-8
                                      UNDER
                           THE SECURITIES ACT OF 1933

                               NEUREX CORPORATION
             [Exact name of Registrant as specified in its charter]

                      Delaware                     77-0128552
             (State or other jurisdiction        (I.R.S. Employer
                     of incorporation)            Identification No.)

                                3760 Haven Avenue
                          Menlo Park, California 94025
                    (Address of Principal Executive Offices)

        Neurex Corporation 1988 Employee and Consultant Stock Option Plan
              Neurex Corporation 1997 Employee Stock Purchase Plan
                              (Full title of Plans)

                               Paul Goddard, Ph.D.
                      Chairman and Chief Executive Officer
                               Neurex Corporation
                                3760 Haven Avenue
                          Menlo Park, California 94025
                                 (415) 853-1500
            (Name, address and telephone number of agent for service)

             Copies to:                Wise & Shepard
                                       3030 Hansen Way, Suite 100
                                       Palo Alto, California 94304
                                       (415) 856-1200
                                       Attention:  Thomas L. Barton, Esq.

               Approximate date of commencement of proposed sales:
                   From time to time after the effective date
                         of this Registration Statement
================================================================================
                         CALCULATION OF REGISTRATION FEE
<TABLE>
     <S>                         <C>                        <C>                        <C>                        <C>             
     --------------------------- -------------------------- -------------------------- -------------------------- ------------------
      Title of each class of                                        Proposed               Proposed maximum          Amount of
         securities to be        Amount to be registered     maximum offering price           aggregate             registration
            registered                                           per share (1)            offering price (1)          fee (1)
     --------------------------- -------------------------- -------------------------- -------------------------- ------------------
           Common Stock,
          par value $0.01                 400,000(2)                 $13.00                    $5,200,000            $1,575.76
     --------------------------- -------------------------- -------------------------- -------------------------- ------------------
     --------------------------- -------------------------- -------------------------- -------------------------- ------------------
           Common Stock,
          par value $0.01                1,000,000(3)                $13.00                   $13,000,000            $3,939.39
     --------------------------- -------------------------- -------------------------- -------------------------- ------------------
     --------------------------- -------------------------- -------------------------- -------------------------- ------------------
               Total                    1,400,000                                             $18,200,000             $5515.15
     --------------------------- -------------------------- -------------------------- -------------------------- ------------------
</TABLE>

(1)    Pursuant to Rule 457(h) and Rule 457(c),  the proposed  maximum  offering
       price  per  share  and the  registration  fee are  based on the  reported
       average of the bid and asked prices for Neurex  Corporation  Common Stock
       on the  NASDAQ  National  Market  System  on July 17,  1997.  

(2)    Shares reserved for issuance under the Neurex  Corporation  1997 Employee
       Stock Purchase Plan.

(3)    Shares reserved for issuance under the Neurex  Corporation  1988 Employee
       and  Consultant  Stock  Option  Plan (in  addition  to  3,311,111  shares
       previously registered on Form S-8 File No. 33-76976 and Form S-8 filed on
       May 6, 1996.)

================================================================================


<PAGE>


                                     PART I

              INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS (fn 1)

Item 1.  Plan Information.

Item 2.  Registrant Information and Employee Plan Annual Information



                                     PART II

               INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

Item 3.  Incorporation of Documents by Reference.

         The  following  documents  which have  heretofore  been filed by Neurex
Corporation  (the  "Company")  with the Securities and Exchange  Commission (the
"Commission")  pursuant to the Securities  Exchange Act of 1934, as amended (the
"1934 Act"),  and the Securities  Act of 1933, as amended (the "1933 Act"),  are
incorporated by reference herein and shall be deemed to be a part hereof:

   1.  The Company's Annual Report on Form 10-K, as amended, for the fiscal year
       ended December 31, 1996.

   2.  The  Company's  Quarterly  Report on Form 10-Q for the  quarterly  period
       ended March 31, 1997.


   3.  The  Company's Proxy  Statement for its Annual  Meeting, dated April 15,
       1997.

   4.  The description of the Company's Common Stock contained in a Registration
       Statement  on Form S-1  (File  No.  33-96840)  filed  under the 1933 Act,
       including  any amendment or report filed for the purpose of updating such
       description.

         All  documents  subsequently  filed by the Company with the  Commission
pursuant  to  Section  13(a),  13(c),  14 and 15(d) of the 1934 Act prior to the
filing  of a  post-effective  amendment  to this  Registration  Statement  which
indicates that all securities  offered have been sold or which  deregisters  all
securities  then  remaining  unsold,  shall  be  deemed  to be  incorporated  by
reference  in this  Registration  Statement  and  made a part  hereof  from  the
respective  dates of filing such documents  (such  documents,  and the documents
enumerated above,  being hereinafter  referred to as "Incorporated  Documents");
provided,  however, that the documents enumerated above or subsequently filed by
the Company pursuant to Sections 13(a),  13(c), 14, and 15(d) of the 1934 Act in
each year during which the offering  made by this  Registration  Statement is in
effect prior to the filing with the Commission of the Company's Annual Report on
Form  10-K  covering  such  year  shall  not  be  Incorporated  Documents  or be
incorporated  by  reference in this  Registration  Statement or be a part hereof
from and after the filing of such Annual Report on Form 10-K.

         Any statement contained in an Incorporated  Document shall be deemed to
be modified or  superseded  for purposes of this  Registration  Statement to the
extent  that a statement  contained  herein or in any other  subsequently  filed
Incorporated Document modifies or supersedes such statement.  Any such statement
so  modified  or  superseded  shall  not be  deemed,  except as so  modified  or
superseded, to constitute a part of this Registration Statement.

Item 4.  Description of Securities.

         Not applicable.


- -----------------------------------------------------------------------------
1   This information is not required to be included in, and is not incorporated
    by reference in, this Registration Statement.
- -------------------------------------------------------------------------------
<PAGE>

Item 5.  Interests of Named Experts and Counsel.

         The validity of the shares of Common Stock registered hereunder will be
passed upon for the Company by Wise & Shepard LLP, Palo Alto, California.  As of
the date of this Form S-8,  Thomas L.  Barton,  a partner of Wise & Shepard LLP,
and General  Counsel,  Secretary  and a Director of the Company,  holds  119,000
shares of the Company's Common Stock.

Item 6.  Indemnification of Directors and Officers.

         Section  145  of  the  Delaware  General   Corporation  Law  permits  a
corporation  to  indemnify  any director or officer of the  corporation  against
expenses  (including  attorney's  fees),  judgments,  fines and amounts  paid in
settlements actually and reasonably incurred in connection with any action, suit
or  proceeding  brought  by  reason  of the fact  that  such  person is or was a
director or officer of the  corporation,  if such person acted in good faith and
in a manner  that he or she  reasonably  believed to be in or not opposed to the
best interests of the  corporation  and, with respect to any criminal  action or
proceeding, if he or she had no reason to believe his conduct was unlawful. In a
derivative   action,   i.e.,  one  by  or  in  the  right  of  the  corporation,
indemnification  may be made only for expenses actually incurred by any director
or officer in connection with the defense or settlement of an action or suit, if
such  person has acted in good faith and in a manner  that he or she  reasonably
believed  to be in or not  opposed  to the best  interests  of the  corporation,
except  that no  indemnification  shall be made if such  person  shall have been
adjudged to be liable to the corporation, unless and only to the extent that the
court in which the action or suit was brought shall  determine upon  application
that the defendant is reasonably entitled to indemnity for such expenses despite
such adjudication of liability.

         The  Company's  Certificate  of  Incorporation  provides  that,  to the
fullest  extent  permitted by Delaware law, the Company's  directors will not be
liable for monetary damages, for breach of the directors' fiduciary duty of care
to the Company and its  stockholders.  This  provision  and the  Certificate  of
Incorporation   does  not  eliminate  the  duty  of  care  and  in   appropriate
circumstances,  equitable  remedies  such as an  injunction  or  other  forms of
non-monetary  relief would remain  available  under  Delaware law. Each director
will  continue to be subject to liability for breach of the  directors'  duty of
loyalty to the  Company  for acts or  omissions  not in good faith or  involving
intentional  misconduct or knowing violations of law, for acts or omissions that
the director believes to be contrary to the best interests of the Company or its
stockholders,  for any transaction  from which the director  derived an improper
personal benefit,  for acts or omissions  involving a reckless  disregard of the
director's duty to the Company or its stockholders  where the director was aware
or should  have been aware of the risk of serious  injury to the  Company or its
stockholders,  for acts or omissions  that  constitute  an unexcused  pattern of
inattention  that amounts to an abdication of the director's duty to the Company
or its  stockholders,  for  improper  transactions  between the director and the
Company,  and for improper  distributions to stockholders and loans to directors
and   officers.   This   provision   also  does  not   affect   the   director's
responsibilities  under any other laws such as the  federal  securities  laws or
state or federal environmental laws.

         The Company has an insurance policy covering the liability and expenses
which might be incurred in connection with lawful  indemnification  of directors
and  officers of the Company and its  majority  owned  subsidiaries  for certain
liabilities  and  expenses  of such  directors  and  officers  for acts in those
capacities.  Such  directors  and  officers  are also  insured  against  certain
liabilities and expense  incurred for acts in such capacities and for which they
are not entitled to indemnification by the Company.

         The  Company's  Bylaws  provide  that  the  Company  has the  power  to
indemnify  its  directors  and officers to the fullest  extent  permitted by the
Delaware General Corporation Law.


Item 7.  Exemption from Registration Claimed.

         Not applicable.

Item 8.  Exhibits.

         The Exhibits  listed in the  following  Exhibit Index are filed as part
of, or incorporated by reference into, this Registration Statement.

Exhibit            Number Description

4.1                Amended and Restated  Certificate of  Incorporation of Neurex
                   Corporation,  dated  September 27, 1993 (filed as Exhibit 3.1
                   to Registrant's Form 10-K for the fiscal year ended September
                   30, 1993, file number  0-19874,  and  incorporated  herein by
                   reference).


4.2                Amended and Restated Bylaws of Neurex Corporation, as adopted
                   by the Board of Directors and  Stockholders  November 6, 1987
                   and as amended on March 3,  1988,  January 1, 1989,  November
                   16,  1989 and  December  8,  1992  (filed as  Exhibit  3.2 to
                   Registrant's  Registration  Statement  on Form S-1,  File No.
                   33-63888 and incorporated herein by reference).

4.3                Neurex Corporation Amended 1988 Employee and Consultant Stock
                   Option Plan*

4.4                1997 Employee Stock Purchase Plan*

5                  Opinion of Wise & Shepard LLP*

23.1               Consent of Wise & Shepard LLP (included in Exhibit 5)


23.2               Consent of Ernst & Young LLP, Independent Auditors*

24                 Power of Attorney (included on signature page hereto)
- ------------------------------------------------------------------------------
                     
 *       filed herewith


Item 9.  Undertakings.

(1)      The undersigned registrant hereby undertakes:

         (a) To file, during any period in which offers or sales are being made,
a post-effective amendment to this registration statement:

              (i) To include any prospectus  required by Section 10(a)(3) of the
Securities Act of 1933;

              (ii)To reflect in the prospectus any facts or events arising after
the  effective  date  of  the   registration   statement  (or  the  most  recent
post-effective  amendment  thereof)  which,  individually  or in the  aggregate,
represent a fundamental  change in the information set forth in the registration
statement;

              (iii) To include any material information with respect to the plan
of distribution not previously  disclosed in the  registration  statement or any
material change to such information in the registration statement;

provided,  however, that paragraphs (1)(a)(i) and (1)(a)(ii) do not apply if the
registration statement is on Form S-3, Form S-8, or Form F-3 and the information
required to be included in a  post-effective  amendment by those  paragraphs  is
contained in periodic reports filed by the registrant  pursuant to Section 13 or
Section 15(d) of the Securities  Exchange Act of 1934 that are  incorporated  by
reference in this Registration Statement;

         (b) That,  for the  purpose  of  determining  any  liability  under the
Securities Act of 1933, each such post-effective amendment shall be deemed to be
a new registration statement relating to the securities offered therein, and the
offering of such  securities at that time shall be deemed to be the initial bona
fide offering thereof; and

         (c) To remove from registration by means of a post-effective  amendment
any of the securities being registered which remain unsold at the termination of
the offering.

(2) The  undersigned  registrant  hereby  undertakes  that,  for the  purpose of
determining  any liability  under the Securities Act of 1933, each filing of the
registrant's  annual  report  pursuant to Section  13(a) or Section 15(d) of the
Securities  Exchange  Act of 1934  (and,  where  applicable,  each  filing of an
employee  benefit  plan's  annual  report  pursuant  to  Section  15(d)  of  the
Securities  Exchange  Act of 1934)  that is  incorporated  by  reference  in the
registration  statement  shall  be  deemed  to be a new  registration  statement
relating to the securities offered therein,  and the offering of such securities
at that time shall be deemed to be the initial bona fide offering thereof.

(3) Insofar as indemnification  for liabilities arising under the Securities Act
of 1933 (the "Act") may be permitted  to  directors,  officers  and  controlling
persons of the registrant  pursuant to the foregoing  provisions,  or otherwise,
the  registrant  has been  advised  that in the  opinion of the  Securities  and
Exchange  Commission such  indemnification is against public policy as expressed
in the Act and is,  therefore,  unenforceable.  In the  event  that a claim  for
indemnification  against  such  liabilities  (other  than  the  payment  by  the
registrant of expenses  incurred or paid by a director,  officer or  controlling
person of the  registrant  in the  successful  defense  of any  action,  suit or
proceeding)  is  asserted by such  director,  officer or  controlling  person in
connection with the securities being registered,  the registrant will, unless in
the opinion of its counsel the matter has been settled by controlling precedent,
submit  to a  court  of  appropriate  jurisdiction  the  question  whether  such
indemnification  by it is against public policy as expressed in the Act and will
be governed by the final adjudication of such issue.


                                   SIGNATURES

         Pursuant to the requirements of the Securities Act of 1933, as amended,
Registrant certifies that it has reasonable grounds to believe that it meets all
of the requirements for filing on Form S-8 and has duly caused this Registration
Statement  to be  signed  on its  behalf  by  the  undersigned,  thereunto  duly
authorized,  in the City of Menlo Park, State of California, on this 17th day of
July, 1997.

                                            NEUREX CORPORATION

                                            By:  /s/  Paul Goddard
                                                 Paul Goddard, Ph.D.
                                                 Chairman of the Board
                                                 Chief Executive Officer,
                                                 President and Director


                                POWER OF ATTORNEY
         Know all men by these presents, that each officer or director of Neurex
Corporation  whose signature appears below constitutes and appoints Paul Goddard
and  John  Varian,   and  each  of  them  severally   her/his  true  and  lawful
attorney-in-fact  and agent,  with full and several power of  substitution,  for
her/him and in her/his name, place and stead, in any and all capacities, to sign
any or all amendments,  including  post-effective  amendments and supplements to
this  Registration  Statement,  and to file the same, with all exhibits thereto,
and other  documents in connection  therewith,  with the Securities and Exchange
Commission,  granting  unto  said  attorney-in-fact  and  agent  full  power and
authority to do and perform each and every act and thing requisite and necessary
to be done in and about the  premises,  as fully to all intents and  purposes as
they or she/he might or could do in person,  hereby ratifying and confirming all
that  said  attorney-in-fact  and  agent  or  her/his  or  their  substitute  or
substitutes may lawfully do or cause to be done by virtue thereof.

         Pursuant to the requirements of the Securities Act of 1933, as amended,
this  Registration  Statement has been signed below by the following  persons in
the capacities indicated and on the dates set forth opposite their signature.

<TABLE>
<S>                                       <C>                                           <C>       
             Signature                    Title                                         Date

/s/     Paul Goddard, PhD.                Chairman of the Board,                        July 17, 1997
- ----------------------------------
        Paul Goddard, Ph.D.               Chief Executive Officer, President and
                                          Director (Principal Executive Officer)

/s/     John Varian                       Vice President of Finance and                 July 17, 1997
- ----------------------------------
        John Varian                       Administration, Chief Financial
                                          Officer and Treasurer (Principal
                                          Financial and Accounting Officer)

/s/     Roberto Crea, Ph.D.               Senior Vice President of Research and         July 17, 1997
- ----------------------------------
        Roberto Crea, Ph.D.               Technology Development and Director

/s/     Robert R.  Luther, M.D.           Executive Vice-President                      July 17, 1997
- ----------------------------------
        Robert R. Luther, M.D.            of Development and Director

/s/     Thomas L. Barton                  General Counsel, Secretary and                July 17, 1997
- ----------------------------------
        Thomas L. Barton                  Director

/s/     David L. Anderson                 Director                                      July 17, 1997
- ----------------------------------
        David L. Anderson

/s/     Gerard N. Burrow, M.D.            Director                                      July 17, 1997
- ----------------------------------
        Gerard N. Burrow, M.D.

/s/     John F. Chappell                  Director                                      July 17, 1997
- ----------------------------------
        John F. Chappell

/s/     Ray L.  Egan                      Director                                      July 17, 1997
- ----------------------------------
        Ray L. Egan

/s/     John W. Glynn                     Director                                      July 17, 1997
- ----------------------------------
        John W. Glynn

/s/     Howard E. Greene, Jr.             Director                                      July 17, 1997
- ----------------------------------
        Howard E. Greene, Jr.

</TABLE>


===============================================================================

                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549



                                    EXHIBITS

                                   filed with

                             Registration Statement

                                       On

                                    Form S-8

                                      Under

                           The Securities Act of 1933




                               Neurex Corporation
               (Exact name of issuer as specified in its charter)



================================================================================




<PAGE>


                               Neurex Corporation




Exhibit Number    Description                                         Sequential
                                                                     Page Number

4.3               Neurex  Corporation  Amended 1988 Employee                 10
                  and Consultant Stock Option Plan

4.4               Neurex  Corporation  1997  Employee  Stock                 20
                  Purchase Plan

5                 Opinion of Wise & Shepard LLP                              31

23.2              Consent of Ernst & Young LLP, Independent                  34
                  Auditors





                                  EXHIBIT 4.3

                               NEUREX CORPORATION

                 1988 EMPLOYEE AND CONSULTANT STOCK OPTION PLAN

                     (As Amended effective February 6, 1997)



      1. Purpose of the Plan.  The purposes of the 1988 Employee and  Consultant
Stock  Option Plan,  as amended and  restated on February 6, 1992,  February 24,
1994,  and March 30,  1995  (the  "Plan")  of  Neurex  Corporation,  a  Delaware
corporation (the "Company"), are to:

           (a)  Furnish  incentive  to  individuals  chosen to  receive  options
because they are  considered  capable of responding by improving  operations and
increasing profits;

           (b)  Encourage  selected  employees  and  consultants  to  accept  or
continue employment with, or consulting to, the Company or its affiliates; and

           (c) Increase the interest of selected  employees and  consultants  in
the Company's welfare through their  participation in the growth in value of the
Company's Common Stock ("Common Stock").

           To accomplish  the foregoing  objectives,  this Plan provides a means
whereby  employees,  directors,  and consultants may receive options to purchase
Common Stock.  Options granted under this Plan will be either nonstatutory stock
options  (subject to federal income  taxation upon exercise) or incentive  stock
options  (generally  not  subject to  immediate  federal  income  taxation  upon
exercise).

      2.  Eligible  Persons.  Every  individual  who at the  date of grant is an
employee  of the  Company  or of any parent or  subsidiary  of the  Company  (as
defined in  subsection  5.1(c)  below) is  eligible to receive  incentive  stock
options and nonstatutory stock options to purchase Common Stock under this Plan.
The term  "employee"  includes an officer or director  who is an employee of the
Company or a parent or subsidiary of it, as well as a non-officer,  non-director
employee of the Company or a parent or subsidiary of it. Every individual who at
the date of grant is a consultant to, or a non-employee director of, the Company
or of any  affiliate  of the Company  (as  defined in Section 150 of  California
Corporations Code) is eligible to receive nonstatutory stock options to purchase
Common  Stock under this Plan,  but shall not be  eligible to receive  incentive
stock  options.  The term  "consultant"  includes  individuals  employed  by, or
otherwise  affiliated  with,  a  person  providing  consulting  services  to the
Company.  

      Subject to the limitations of Section 3, below, each non-employee director
serving  on the  Board as of March 30 of each year will be  granted  options  to
purchase 8,000 shares of Common Stock, and each non-employee director elected or
appointed to the Board after March 30, 1995 will initially be granted options to
purchase  12,000 shares of Common Stock,  and will thereafter be granted options
to purchase 8,000 shares of Common Stock on March 30 of each year for so long as
they serve as directors of the Company. Such non-employee director options shall
become  exercisable over a three (3) year period,  however,  in the event of any
merger,  reorganization,  or consolidation of the Company with or into any other
entity,  or the sale of all or substantially  all of the Company's  assets,  all
such option grants shall immediately become exercisable.

      3. Common Stock Subject to Plan.

           (a) There  shall be reserved  for issue upon the  exercise of options
granted under this Plan four million three hundred  eleven  thousand one hundred
eleven (4,311,111) shares of Common Stock,  subject to adjustment as provided in
Section 7 hereof.  If an option granted under the Plan shall expire or terminate
for any reason without having been  exercised in full,  the  unpurchased  shares
subject thereto shall again be available for the purposes of the Plan.

           (b)  Notwithstanding any other provisions of this Plan, the aggregate
number of shares of Common Stock subject to  outstanding  options  granted under
this Plan,  plus the aggregate  number of shares issued upon the exercise of all
options  granted under this Plan,  shall never be permitted to exceed the number
of shares specified in the first sentence of subsection 3(a) above.

      4.  Administration.  The  Plan  shall  be  administered  by the  Board  of
Directors  (the  "Board")  of the  Company,  or by a  committee  of two or  more
directors  appointed  by the Board,  each of who is a  disinterested  person (in
either case, the  "Administrator").  No option shall be granted to a director or
officer of the Company,  except by the Board,  if each member is a disinterested
person,  or  otherwise  by an  Administrator  comprised  of less than the entire
Board.  "Disinterested  Person"  shall  have  the  meaning  set  forth  in  Rule
16b-3(c)(2)(ii),  as promulgated by the Securities and Exchange Commission under
the  Securities  Exchange Act of 1934 (the  "Exchange  Act"),  or any  successor
definition adopted by the Commission.  Rule 16b-3(c)(2)(ii)  currently defines a
disinterested person as a director who has not, during the one (1) year prior to
services  as  an  administrator  of a  plan,  been  granted  or  awarded  equity
securities  pursuant  to the Plan or any other  plan of the issuer or any of its
affiliates, subject to certain limited exceptions.

      The Administrator may delegate  nondiscretionary  administrative duties to
such  employees  of the  Company  as it deems  proper.  Subject to the terms and
conditions  of this  Plan,  and  except  as  otherwise  set  forth  herein,  the
Administrator shall have the sole authority, in its discretion:

           (a) to determine to which of the eligible  individuals,  and the time
or times at which,  options to purchase  Common  Stock of the  Company  shall be
granted;

           (b) to  determine  the number of shares of Common Stock to be subject
to options granted to each eligible individual;

           (c) to determine  the price to be paid for the shares of Common Stock
upon the exercise of each option;

           (d) to determine the term and the exercise schedule of each option;

           (e) to  determine  the  terms and  conditions  of each  stock  option
agreement (which need not be identical) entered into between the Company and any
eligible individual to whom the Administrator has granted an option;

           (f) to interpret the Plan;

           (g) to  accelerate  the exercise date or schedule with respect to any
option  granted  under the Plan or, with the consent of the holder  thereof,  to
modify or amend any such option; and

           (h) to make all determinations  deemed necessary or advisable for the
administration of the Plan.

      5. Terms of Options. Each option granted under the Plan shall be evidenced
by a stock option agreement between the individual to whom the option is granted
(the "optionee") and the Company. Each such agreement shall designate the option
thereby granted as an incentive stock option, or a nonstatutory  stock option or
in part an incentive stock option, and in part a nonstatutory stock option. Each
such  agreement  shall be  subject  to the  terms  and  conditions  set forth in
subsection 5.1, and to such other terms and conditions not inconsistent herewith
as the Administrator  may deem appropriate in each case. In addition,  incentive
stock  options  shall be  subject  to the  terms  and  conditions  set  forth in
subsection 5.2.

      5.1 Terms and  Conditions  to Which All Options Are  Subject.  All options
granted under this Plan shall be subject to the following terms and conditions:

           (a) Term of Options. The period or periods within which an option may
be exercised shall be determined by the  Administrator at the time the option is
granted,  and such period or periods may be amended subsequently only by written
mutual agreement of the Company (at the direction of the  Administrator) and the
optionee.  In no event shall such period  extend  beyond ten (10) years from the
date the option is granted in the case of an incentive  stock option or ten (10)
years and one (1) week  from the date the  option  is  granted  in the case of a
nonstatutory stock option.

           (b)  Exercise  Price.  The price to be paid for each  share of Common
Stock upon the exercise of an option shall be determined by the Administrator at
the time the option is granted,  but shall in no event be less than  eighty-five
percent  (85%) in the  case of a  nonstatutory  stock  option,  and one  hundred
percent  (100%) in the case of an  incentive  stock  option,  of the fair market
value of a share of  Common  Stock on the date the  option is  granted.  For all
purposes  of this  Plan,  the  fair  market  value  of the  Common  Stock on any
particular  date shall be the closing  price on the  trading day next  preceding
that date on the principal  securities  exchange on which the  Company's  Common
Stock is listed,  or, if such Common Stock is not then listed on any  securities
exchange,  then the fair market  value of the Common Stock on such date shall be
the mean of the  closing  bid and  asked  prices  as  reported  by the  National
Association of Securities Dealers, Inc. Automated Quotation System ("NASDAQ") on
the trading day next preceding such date. In the event that the Company's Common
Stock is neither listed on a securities  exchange nor quoted by NASDAQ, then the
Administrator  shall  determine  the fair market value of the  Company's  Common
Stock on such date.

      Notwithstanding  the above provisions of this Section 5.1(b), the exercise
price of all options granted to the Company's non-employee directors will be the
closing  bid price of the Common  Stock as reported by NASDAQ on the grant date.
The  preceding  sentence  shall not apply if the  Common  Stock is not quoted by
NASDAQ.

           (c) More than Ten Percent Shareholders. No option shall be granted to
any  individual  who,  at the time such  option  would be  granted,  owns  stock
possessing more than ten percent (10%) of the total combined voting power of all
classes  of  outstanding  capital  stock  of  the  Company,  or  of  any  parent
corporation or subsidiary corporation of the Company,  unless the exercise price
(as  provided in  subsection  5.1(b)  hereof) is, in the case of a  nonstatutory
stock  option,  not less than one hundred  percent  (100%) and in the case of an
incentive stock option, not less than one hundred ten percent (110%) of the fair
market value of the Common  Stock on the date the option is granted,  and in the
case of an  incentive  stock  option the period  within  which the option may be
exercised  (as provided in  subsection  5.1(a)  hereof) does not exceed five (5)
years from the date the  option is  granted.  For  purposes  of this  subsection
5.1(c) in determining stock ownership, an optionee shall be considered as owning
the voting capital stock owned,  directly or indirectly,  by or for his brothers
and sisters,  spouse,  ancestors and lineal  descendants.  Voting  capital stock
owned, directly or indirectly, by or for a corporation,  partnership,  estate or
trust  shall  be  considered  as  being  owned  proportionately  by or  for  its
shareholders, partners or beneficiaries, as applicable. An optionee shall not be
considered  as owning the shares of Common Stock  issuable  upon exercise of any
option which such optionee holds. Additionally,  for purposes of this subsection
5.1(c),  outstanding  capital  stock shall  include all capital  stock  actually
issued  and  outstanding  immediately  after  the  grant  of the  option  to the
optionee.  Outstanding  capital stock shall not include capital stock authorized
for issue under outstanding options held by the optionee or by any other person.
As  used  in  this  Plan,  the  terms  "parent   corporation"   and  "subsidiary
corporation"  shall  have the  meanings  set forth in  Sections  424(e) and (f),
respectively, of the Internal Revenue Code of 1986, as amended (the "I.R.C.")

           (d) Method of Payment for Common Stock.  The exercise  price for each
share of Common Stock purchased under an option shall be paid in full in cash at
the time of purchase.

           (e) Nontransferability.  All options shall be nontransferable, except
by will or the laws of descent and distribution, and shall be exercisable during
the lifetime of the optionee only by the optionee.

           (f)  Repurchase  of Stock.  At the option of the  Administrator,  the
stock to be  delivered  pursuant  to the  exercise  of any option  granted to an
employee under this Plan may be subject to a right of repurchase in favor of the
Company  with  respect to any  employee  whose  employment  with the  Company is
terminated,  with respect to any consultant  whose  consultancy  has terminated,
and/or with respect to any  non-employee  director whose membership on the Board
of Directors is  terminated.  Any such right of  repurchase  of unvested  shares
shall be at the  option  exercise  price and any such  right of  repurchase  for
vested  shares  shall be at the higher of the fair market value of the shares as
of the  termination  date or the  option  exercise  price.  Any  such  right  of
repurchase  shall expire at such times and with respect to such number of shares
as set by the  Administrator.  Determination  of the number of shares subject to
such right of repurchase shall be made as of the date the employee or consultant
or director's relationship with the Company terminates,  not as of the date that
any option granted to such employee, consultant or director is exercised.

           (g) Withholding  and Employment  Taxes. At the time of exercise of an
option,  the  optionee  shall remit to the Company in cash the amount of any and
all applicable federal and state withholding and employment taxes.

           (h)  Death.  Upon the death of an  employee,  any  option  which such
employee holds may be exercised by such  employee,  within such period after the
date  of  death  as  the  Administrator  shall  prescribe  in the  stock  option
agreement,  by the employee's  representative  or by the person entitled thereto
under the employee's will or the laws of intestate succession.

           (i)  Disability.  Upon  the  permanent  and  total  disability  of an
employee (as defined in Section 105(d)(4) of the I.R.C.), any stock option which
the employee holds may be exercised by the employee within such period after the
date of termination of employment  resulting from such disability (not to exceed
twelve  (12)  months  in  the  case  of  an  incentive   stock  option)  as  the
Administrator  shall prescribe in the stock option  agreement.  The option shall
terminate upon the  expiration of such  prescribed  period,  unless the employee
dies prior thereto,  in which event the  provisions of subsection  5.1(h) hereof
shall apply.

           (j) Retirement. Upon the voluntary retirement of an employee at or
after  reaching  sixty-five  (65)  years of age,  any stock  option  which  such
employee  holds may be  exercised  by such  employee  with respect to all or any
portion of the balance of the Common Stock  subject  thereto  within such period
after the date of  retirement  (not to exceed three (3) months in the case of an
incentive stock option) as the Administrator shall prescribe in the stock option
agreement.  The option shall  terminate upon the  expiration of such  prescribed
period, unless the employee dies prior thereto, in which event the provisions of
subsection 5.1(h) hereof shall apply.

           (k)  Transfer to Related  Corporation.  In the event that an employee
leaves  the  employ  of the  Company  to  become an  employee  of any  parent or
subsidiary  corporation of the Company,  or if the employee leaves the employ of
any such parent or subsidiary  corporation  to become an employee of the Company
or of another parent or subsidiary corporation, such employee shall be deemed to
continue as an employee of the Company for all purposes of this Plan.

           (l) Other  Severance.  In the event an employee  leaves the employ of
the Company for any reason  other than as set forth in  subsections  (h) through
(j), above,  any stock option which such employee holds may be exercised by such
employee  with  respect to all or any portion of the balance of the Common Stock
subject  thereto  within such period after the date of severance  (not to exceed
three (3) months in the case of an incentive stock option) as the  Administrator
shall prescribe in the stock option agreement.

           (m) Other Provisions. Each option granted under this Plan may contain
such other terms,  provisions and conditions not inconsistent  with this Plan as
may be determined by the Administrator.  However, options granted after the date
the Common Stock of the Company is first quoted on the National  Association  of
Securities Dealers Automated  Quotation System or listed on an established stock
exchange  shall not contain any  provisions  giving the Company a right of first
refusal to purchase the Common Stock underlying the options.

      5.2 Additional  Terms and Conditions to Which  Incentive Stock Options Are
Subject. Options granted under this Plan which are designated as incentive stock
options shall be subject to the following additional terms and conditions:

           (a) Annual Limitation.  To the extent the aggregate fair market value
(determined  as of the date an  incentive  stock option is granted) of the stock
with respect to which  incentive  stock options  granted are exercisable for the
first time by an employee  during any one (1) calendar year (under this Plan and
under  all  other  plans  of  the  Company  and  of  any  parent  or  subsidiary
corporation) exceed One Hundred Thousand Dollars ($100,000),  such options shall
be treated as options which are not incentive stock options.

           (b) Disqualifying Dispositions.  If Common Stock acquired by exercise
of an incentive stock option granted pursuant to this Plan is disposed of within
two (2) years  from the date of grant of the option or within one (1) year after
the transfer of the Common Stock to the optionee, the holder of the Common Stock
immediately  prior to the  disposition  shall  promptly  notify  the  Company in
writing of the date and terms of the  disposition  and shall  provide such other
information regarding the disposition as the Company may reasonably require.

      6. Stock  Issuance and Rights as  Shareholder.  Notwithstanding  any other
provisions  of  the  Plan,  no  optionee  shall  have  any of  the  rights  of a
shareholder  (including the right to vote and receive dividends) of the Company,
by reason of the  provisions of this Plan or any action taken  hereunder,  until
the date such  optionee  shall both have paid the exercise  price for the Common
Stock and shall have been issued (as evidenced by the  appropriate  entry on the
books of the Company or of a duly authorized  transfer agent of the Company) the
stock certificate evidencing such shares.

      7. Adjustments Upon Changes in Capitalization or Merger.

           (a) Subject to any required action by the Company's shareholders, the
number of shares of Common Stock  covered by this Plan as provided in Section 3,
the number of shares covered by each  outstanding  option granted  hereunder and
the exercise price thereof shall be proportionately adjusted for any increase or
decrease  in the  number of  issued  shares of  Common  Stock  resulting  from a
subdivision or  consolidation  of such shares or the payment of a stock dividend
(but only on the Common  Stock) or any other  increase or decrease in the number
of such  outstanding  shares of Common  Stock  effected  without  the receipt of
consideration  by the Company;  provided,  however,  that the  conversion of any
convertible securities of the Company shall not be deemed to have been "effected
without receipt of consideration."

           (b) Subject to any required action by the Company's shareholders,  if
the Company shall be the surviving  corporation in any merger or  consolidation,
each  outstanding  option shall  pertain and apply to the  securities to which a
holder of the number of shares subject to the option would have been entitled. A
dissolution or liquidation of the Company or a merger or  consolidation in which
the Company is not the surviving corporation shall cause each outstanding option
to  terminate,  unless  the  surviving  corporation  in the case of a merger  or
consolidation  assumes  outstanding  options or  replaces  them with  substitute
options having substantially  similar terms and conditions;  provided,  however,
that  if an  outstanding  option  is to  terminate  upon  any  such  event,  the
Administrator  on such  terms  and  conditions  as it deems  appropriate,  shall
provide  either by the terms of the stock  option  agreement  or by a resolution
adopted prior to the occurrence of any such event, that, for some period of time
prior to such event,  such option shall be  exercisable  as to all of the shares
covered by the portion of the option that previously has not lapsed, terminated,
or been exercised,  notwithstanding  any exercise schedule provided in the stock
option agreement.

           (c) To the extent that the foregoing  adjustments  relate to stock or
securities of the Company,  such adjustments  shall be made by the Board,  whose
determination in that respect shall be final, binding and conclusive.

           (d) Except as  hereinabove  expressly  provided in this Section 7, no
optionee shall have any rights by reason of any subdivision or  consolidation of
shares of the capital stock of any class or the payment of any stock dividend or
any other increase or decrease in the number of shares of any class or by reason
of any dissolution,  liquidation,  merger or consolidation or spin-off of assets
or stock of another corporation, and any issue by the Company of shares of stock
of any  class or of  securities  convertible  into  shares of stock of any class
shall not affect, and no adjustment by reason thereof shall be made with respect
to, the number or price of shares subject to any option granted hereunder.

           (e) The grant of an option  pursuant to this Plan shall not affect in
any  way  the   right   or   power   of  the   Company   to  make   adjustments,
reclassifications,  reorganizations  or  changes  of  its  capital  or  business
structure or to merge or consolidate or to dissolve, liquidate, sell or transfer
all or any part of its business or assets.

      8. Manner of  Exercise.  An optionee  wishing to exercise an option  shall
give written  notice to the Company at its principal  executive  office,  to the
attention  of the  Secretary  of the  Company,  accompanied  by  payment  of the
exercise price as provided in subsection  5.1(b).  The date the Company receives
written notice of an exercise  hereunder  accompanied by payment of the exercise
price will be considered as the date such option was exercised.

      Promptly  after  receipt of written  notice of exercise of an option,  the
Company  shall,  without stock issue or transfer  taxes to the optionee or other
person  entitled to exercise  the option,  deliver to the optionee or such other
person a certificate or certificates for the requisite number of shares of stock
pursuant to the terms of the option agreement.

      9.  Employment  or  Consulting  Relationship.  Nothing in this Plan or any
option granted  hereunder  shall interfere with or limit in any way the right of
the Company or of any of its Affiliates to terminate any optionee's  employment,
consultancy, or directorship at any time, nor confer upon any optionee any right
to continue as an employee of, consultant to, or director of, the Company or any
of its parent or subsidiaries.

      10. Securities Law Requirements.

           (a) The Administrator may require an individual as a condition of the
grant and of the  exercise  of an option,  to  represent  and  establish  to the
satisfaction of the Administrator that all shares of Common Stock to be acquired
upon the  exercise of such option will be acquired  for  investment  and not for
resale. The Administrator  shall cause such legends to be placed on certificates
evidencing  shares of Common Stock issued upon  exercise of an option as, in the
opinion of the  Company's  counsel,  may be required  by federal and  applicable
state securities laws.

           (b) No shares of Common  Stock shall be issued  upon the  exercise of
any option unless and until  counsel for the Company  determines  that:  (i) the
Company and the optionee have  satisfied all applicable  requirements  under the
Securities  Act of 1933, as amended,  and the Exchange Act; (ii) any  applicable
requirement  of any stock  exchange or quotation  system on which the  Company's
Common  Stock is  listed  or  quoted  has been  satisfied;  and  (iii) all other
applicable provisions of state and federal law have been satisfied.

      11.  Amendment.  The Board may  terminate  the Plan or amend the Plan from
time to time in such  respects  as the Board may deem  advisable,  except  that,
without the  approval  of the  Company's  shareholders  in  compliance  with the
requirements of applicable law, no such revision or amendment shall:

           (a)  increase  the number of shares of Common  Stock  reserved  under
Section 3 hereof  for issue  under the Plan,  except as  provided  in  Section 7
hereof;

           (b) change the class of persons  eligible to  participate in the Plan
under Section 2 hereof;

           (c) extend the term of the Plan under Section 12 hereof; or

           (d) amend this Section 11 to defeat its purpose.

      12. Termination. The Plan shall terminate automatically on April 20, 1998,
and may be  terminated  at any  earlier  date by the Board.  No option  shall be
granted  hereunder after termination of the Plan, but such termination shall not
affect the validity of any option then outstanding.

      13. Time of  Granting  Options.  The date of grant of an option  hereunder
shall,  for all  purposes,  be the date on which  the  Administrator  makes  the
determination granting such option.

      14. Reservation of Shares. The Company, during the term of this Plan, will
at all times  reserve  and keep  available  such  number of shares of its Common
Stock as shall be sufficient to satisfy the requirements of the Plan.

      15.  Effective Date. This Plan shall become effective upon adoption by the
Board of Directors of the Company, and shall be effective on said date, provided
the Plan is approved within twelve (12) months of said date by the  shareholders
of the Company in accordance with the Certificate of Incorporation and Bylaws of
the  Company  and  the  requirements  of the  I.R.C.  and the  Delaware  General
Corporation Law. Options may be granted, but may not be exercised,  prior to the
date of such shareholder approval.


As amended to February 6, 1997.





                                  EXHIBIT 4.3


                               NEUREX CORPORATION

                        1997 EMPLOYEE STOCK PURCHASE PLAN

                                 
                              Adopted May 15, 1997


1.       Purpose.

         (a) The purpose of the Plan is to provide a means by which employees of
Neurex Corporation,  a Delaware corporation (the "Company"), and its Affiliates,
as defined in subparagraph (b), which are designated as provided in subparagraph
2(b), may be given an opportunity to purchase stock of the Company.

         (b)  The  word  "Affiliate"  as  used  in the  Plan  means  any  parent
corporation or subsidiary corporation of the Company, as those terms are defined
in Sections 424(e) and (f), respectively,  of the Internal Revenue Code of 1986,
as amended (the "Code").

         (c) The Company,  by means of the Plan, seeks to retain the services of
its  employees,  to secure and  retain the  services  of new  employees,  and to
provide  incentives for such persons to exert maximum efforts for the success of
the Company.

         (d) The  Company  intends  that the  rights  to  purchase  stock of the
Company  granted under the Plan be considered  options issued under an "employee
stock purchase plan" as that term is defined in Section 423(b) of the Code.

2.       Administration.

         (a) The Plan  shall be  administered  by the  Board of  Directors  (the
"Board") of the Company unless and until the Board delegates administration to a
Committee,  as  provided  in  subparagraph  2(c).  Whether  or not the Board has
delegated administration,  the Board shall have the final power to determine all
questions of policy and expediency that may arise in the  administration  of the
Plan.

         (b) The  Board  shall  have the  power,  subject  to,  and  within  the
limitations of, the express provisions of the Plan:

                  (i) To determine  when and how rights to purchase stock of the
Company  shall be granted  and the  provisions  of each  offering of such rights
(which need not be identical).

                  (ii) To designate  from time to time which  Affiliates  of the
Company shall be eligible to participate in the Plan.

                  (iii) To construe and  interpret  the Plan and rights  granted
under it, and to  establish,  amend and  revoke  rules and  regulations  for its
administration.  The Board,  in the  exercise  of this  power,  may  correct any
defect,  omission or inconsistency in the Plan, in a manner and to the extent it
shall deem necessary or expedient to make the Plan fully effective.

                  (iv)     To amend the Plan as provided in paragraph 13.

                  (v)  Generally,  to exercise  such powers and to perform  such
acts as the Board deems  necessary or expedient to promote the best interests of
the Company.

         (c) The Board may  delegate  administration  of the Plan to a Committee
composed  of not fewer than two (2) members of the Board (the  "Committee")  who
are non-employee directors.  If administration is delegated to a Committee,  the
Committee  shall have, in connection  with the  administration  of the Plan, the
powers  theretofore   possessed  by  the  Board,   subject,   however,  to  such
resolutions, not inconsistent with the provisions of the Plan, as may be adopted
from  time to time by the  Board.  The Board  shall  otherwise  comply  with the
requirements  of Rule 16b-3  promulgated  under the  Securities  Exchange Act of
1934, as amended (the "Exchange Act"), as from time to time in effect. The Board
may abolish the Committee at any time and revest in the Board the administration
of the Plan.

         (d) The term  "non-employee  director" as used in this Plan, shall mean
an administrator of the Plan,  whether a member of the Board or of any Committee
to which  responsibility  for  administration  of the  Plan  has been  delegated
pursuant  to  subparagraph  2(c),  who is not at the  time  he or she  exercises
discretion in  administering  the Plan receiving annual  compensation  exceeding
$60,000,  either directly or indirectly,  from the Company for services rendered
as a consultant or in any capacity  other than as a Board  member,  and does not
have an  interest  in any  transaction  with the  Company  involving  an  amount
exceeding $60,000.  Any such person shall otherwise comply with the requirements
of Rule l6b-3 promulgated under the Exchange Act as from time to time in effect.

3.       Shares Subject To The Plan.

         (a) Subject to the  provisions of paragraph 12 relating to  adjustments
upon  changes in stock,  the stock that may be sold  pursuant to rights  granted
under the Plan shall not exceed in the aggregate four hundred thousand (400,000)
shares of the Company's common stock (the "Common Stock").  If any right granted
under the Plan shall for any reason terminate without having been exercised, the
Common Stock not purchased under such right shall again become available for the
Plan.

         (b) The stock subject to the Plan may be unissued  shares or reacquired
shares, bought on the open market or otherwise.

4.       Grant Of Rights; Offering.

         The Board or the  Committee  may from time to time grant or provide for
the grant of rights to purchase  Common  Stock of the Company  under the Plan to
eligible  employees (an "Offering") on a date or dates (the "Offering  Date(s)")
selected by the Board or the Committee.  Each Offering shall be in such form and
shall contain such terms and conditions as the Board or the Committee shall deem
appropriate.  The provisions of separate  Offerings  need not be identical,  but
each Offering  shall include  (through  incorporation  of the provisions of this
Plan by reference in the Offering or otherwise)  the substance of the provisions
contained in paragraphs 5 through 8, inclusive.

5.       Eligibility.

         (a) Rights may be granted  only to  employees of the Company or, as the
Board or the  Committee  may  designate  as provided in  subparagraph  2(b),  to
employees of any  Affiliate of the Company.  Except as provided in  subparagraph
5(b),  an employee of the Company or any  Affiliate  shall not be eligible to be
granted rights under the Plan,  unless,  on the Offering Date, such employee has
been in the employ of the Company or any  Affiliate for such  continuous  period
preceding such grant as the Board or the Committee may require,  but in no event
shall the required  period of continuous  employment be equal to or greater than
two (2) years.  In addition,  unless  otherwise  determined  by the Board or the
Committee,  no employee of the Company or any Affiliate  shall be eligible to be
granted rights under the Plan,  unless,  on the Offering Date,  such  employee's
customary  employment with the Company or such Affiliate is at least twenty (20)
hours per week and at least five (5) months per calendar year.

         (b) A director  shall in no event be eligible  for the  benefits of the
Plan  unless  and  until  such  director  is  expressly   declared  eligible  to
participate in the Plan by action of the Board or the Committee, and only if, at
any time  discretion is exercised by the Board in the selection of a director as
a person to whom rights may be granted, or in the determination of the number of
shares that may be covered by rights  granted to a  director,  a majority of the
Board and a majority of the  directors  acting in such  matter are  non-employee
directors,  as defined in subparagraph  2(d). The Board shall  otherwise  comply
with the requirements of Rule 16b-3  promulgated under the Exchange Act, as from
time to time in effect.

         (c) No  employees  shall be eligible  for the grant of any rights under
the Plan if,  immediately after any such rights are granted,  such employee owns
stock possessing five percent (5%) or more of the total combined voting power or
value of all classes of stock of the Company or of any  Affiliate.  For purposes
of this  subparagraph  5(c), the rules of Section 424(d) of the Code shall apply
in determining the stock ownership of any employee, and stock that such employee
may purchase under all outstanding  rights and options shall be treated as stock
owned by such employee.

         (d) An eligible  employee may be granted  rights under the Plan only if
such  rights,  together  with any other rights  granted  under  "employee  stock
purchase  plans" of the  Company and any  Affiliates,  as  specified  by Section
423(b)(8) of the Code, do not permit such employee's rights to purchase stock of
the  Company  or any  Affiliate  to accrue at a rate  that  exceeds  twenty-five
thousand dollars ($25,000) of the fair market value of such stock (determined at
the time such rights are  granted) for each  calendar  year in which such rights
are outstanding at any time.

6.       Rights; Purchase Price.

         (a) On each  Offering  Date,  each  eligible  employee,  pursuant to an
Offering made under the Plan,  shall be granted the right to purchase the number
of shares of Common  Stock of the  Company  purchasable  with up to ten  percent
(10%) of such employee's Base Compensation (as defined in paragraph 7(a)) during
the period that begins on the  Offering  Date and ends on the date stated in the
Offering,  which date shall be no more than  twenty-seven  (27) months after the
Offering Date (the  "Purchase  Period").  In connection  with each Offering made
under this Plan,  the Board or the Committee  shall specify a maximum  number of
shares that may be  purchased  by any  employee  as well as a maximum  aggregate
number of shares that may be  purchased by all  eligible  employees  pursuant to
such Offering. In addition, in connection with each such Offering,  the Board or
the  Committee  may  specify a maximum  aggregate  number of shares  that may be
purchased by all eligible employees pursuant to such Offering.  If the aggregate
purchase of shares upon  exercise of rights  granted  under the  Offering  would
exceed such maximum  aggregate  number,  the Board or the Committee shall make a
pro rata  allocation  of the shares  available in as nearly a uniform  manner as
shall be practicable and as it shall deem to be equitable.

         (b) The purchase  price of stock  acquired  pursuant to rights  granted
under the Plan shall be not less than the lesser of:

                   (i) an amount equal to eighty-five  percent (85%) of the fair
market value of the stock on the Offering Date, or

                   (ii) an amount equal to eight-five  percent (85%) of the fair
market value of the stock on the date of purchase.

         For  purposes of this  paragraph  6(b),  "fair  market  value" shall be
determined by reference to the opening price of a share of the Company's  Common
Stock as quoted on the NASDAQ National Market System.

7.       Participation; Withdrawal; Termination.

   
         (a) An eligible  employee  may become a  participant  in an Offering by
delivering  an  agreement  to the  Company  within  the  time  specified  in the
Offering,  in such  form as the  Company  provides.  Each such  agreement  shall
authorize payroll  deductions of up to ten percent (10%) of such employee's Base
Compensation (for purposes of calculating Base Compensation,  the Administrator,
in  its  discretion,   may  use  current  or  historical   compensation).   Base
Compensation is defined as total cash  compensation,  including  gross,  regular
compensation,  including  any bonuses  and sales  commissions  paid  pursuant to
recurring  compensation  plans, and excluding overtime pay, profit sharing,  any
special, non-recurring payments for extraordinary services, the cost of employee
benefits paid for by the Company,  education or tuition reimbursements,  imputed
income arising under any Company group insurance or benefit  program,  traveling
expenses,  signing bonuses,  business and moving expense reimbursements,  income
received in connection with stock options, and contributions made by the Company
under  any  employee  benefit  plan.  The  payroll   deductions  made  for  each
participant  shall be credited to an account for such participant under the Plan
and shall be deposited with the general funds of the Company. At any time during
the Purchase Period a participant may terminate his or her payroll deductions. A
participant  may not  increase  the  percentage  rate of deduction or begin such
payroll  deductions  effective for a given  Offering  after the beginning of the
Purchase  Period for that  Offering.  A participant  may not make any additional
payments into his or her account unless expressly  provided for in the Offering.
An  eligible  employee  may  not  participate  in an  Offering  if he or  she is
concurrently participating in an offering under another "employee stock purchase
plan" of the Company as that term is defined in Section 423(b) of the Code.
    

         (b) If a  participant  terminates  his or her payroll  deduction,  such
participant may withdraw from the Offering by delivering to the Company a notice
of  withdrawal.  Such  withdrawal may be elected at any time prior to the end of
the Purchase  Period.  Upon such  withdrawal from the Offering by a participant,
the Company shall distribute as soon as practical to such participant all of his
or her accumulated  payroll deductions under the Offering without interest,  and
such participant's rights in that Offering shall be automatically  terminated. A
participant's  withdrawal  from an  Offering  will  have  no  effect  upon  such
participant's  eligibility to participate in any other  Offerings under the Plan
but such participant will be required to deliver a new  participation  agreement
in order to participate in other Offerings under the Plan.

         (c)  Rights  granted  pursuant  to any  Offering  under the Plan  shall
terminate immediately upon cessation of any participating  employee's employment
with  the  Company  or an  Affiliate,  for any  reason,  and the  Company  shall
distribute to such  terminated  employee all of his or her  accumulated  payroll
deductions, without interest.

         (d) Rights granted under the Plan shall not be transferable,  and shall
be exercisable only by the person to whom such rights are granted.

8.       Exercise.

         (a) On the last  business day prior to the end of the  Purchase  Period
(the "Exercise Date"), each participant's accumulated payroll deductions will be
applied  to the  purchase  of whole  shares of stock of the  Company,  up to the
maximum  number of shares  permitted  pursuant  to the terms of the Plan and the
applicable  Offering,  at the  purchase  price  specified  in the  Offering.  No
fractional  shares shall be issued upon the exercise of rights granted under the
Plan. The amount, if any, of accumulated  payroll  deductions  remaining in each
participant's  account after the purchase of shares that is less than the amount
required  to  purchase  one share of stock on the  Exercise  Date of an Offering
shall be held in each such  participant's  account for the purchase of shares in
the next Offering under the Plan,  unless such  participant  withdraws from such
next Offering,  as provided in subparagraph 7(b), or is no longer eligible to be
granted  rights  under the Plan,  as provided in paragraph 5, in which case such
amount  shall be  distributed  to such  participant  after such  Exercise  Date,
without  interest.  The  amount,  if  any,  of  accumulated  payroll  deductions
remaining  in any  participant's  account  after the  purchase of shares that is
equal to an amount that would be sufficient to purchase whole shares of stock on
the  Exercise  Date  of an  Offering  shall  be  distributed  in  full  to  such
participant after such Exercise Date, without interest.

         (b) No rights  granted  under the Plan may be  exercised  to any extent
unless the Plan (including rights granted thereunder) is covered by an effective
registration  statement  pursuant to the Securities Act of 1933, as amended (the
"Securities Act"). If, on an Exercise Date of any Offering  hereunder,  the Plan
is not so registered,  no rights granted under the Plan or any Offering shall be
exercised  and all payroll  deductions  accumulated  during the Purchase  Period
shall be distributed to the participants, without interest.

9.       Covenants Of The Company.

         (a) During the terms of the rights  granted under the Plan, the Company
shall keep  available  for  issuance  at all times the number of shares of stock
required to satisfy such rights.

         (b) The Company shall seek to obtain from each regulatory commission or
agency having  jurisdiction  over the Plan such  authority as may be required to
issue and sell  shares of stock upon  exercise of the rights  granted  under the
Plan.  If, after  reasonable  efforts,  the Company is unable to obtain from any
such regulatory commission or agency the authority which counsel for the Company
deems  necessary for the lawful  issuance and sale of stock under the Plan,  the
Company shall be relieved from any liability for failure to issue and sell stock
upon exercise of such rights unless and until such authority is obtained.

10.      Use Of Proceeds From Stock.

         Proceeds  from the sale of stock  pursuant to rights  granted under the
Plan shall constitute general funds of the Company.

11.      Rights As A Stockholder.

         A  participant  shall not be deemed to be the holder of, or to have any
of the rights of a holder with respect to, any shares  subject to rights granted
under the Plan unless and until certificates representing such shares shall have
been issued.

12.      Adjustments Upon Changes In Stock.

         (a) If any change is made in the stock  subject to the Plan, or subject
to  any  rights   granted  under  the  Plan  (through   merger,   consolidation,
reorganization,  recapitalization,  stock  dividend,  dividend in property other
than cash, stock split, liquidating dividend, combination of shares, exchange of
shares,  change in  corporate  structure  or  otherwise),  the Board  shall make
appropriate  adjustments in the maximum number of shares subject to the Plan and
the number of shares and price per share of stock subject to outstanding rights.

         (b) In the event of: (1) a dissolution  or  liquidation of the Company;
(2) a  merger  or  consolidation  in  which  the  Company  is not the  surviving
corporation;  (3) a  reverse  merger  in  which  the  Company  is the  surviving
corporation but the shares of the Company's Common Stock outstanding immediately
preceding the merger are converted by virtue of the merger into other  property,
whether in the form of securities,  cash of otherwise;  or (4) any other capital
reorganization  in which  more than  fifty  percent  (50%) of the  shares of the
Company entitled to vote are exchanged,  then, as determined by the Board in its
sole discretion,  any surviving  corporation shall assume  outstanding rights or
substitute  similar rights for those under the Plan,  such rights shall continue
in full force and effect, or such rights shall terminate.

13.      Amendment Of Plan.

         (a) The Board at any time,  and from time to time,  may amend the Plan.
However, except as provided in paragraph 12 relating to adjustments upon changes
in stock, no amendment shall be effective unless approved by the stockholders of
the Company  within 12 months  before or after the  adoption  of the  amendment,
where the amendment will:

                   (i) Increase  the number of shares  reserved for rights under
the Plan; or

                   (ii)   Modify   the   provisions   as  to   eligibility   for
participation in the Plan; or

                  (iii)   Materially   increase   the   benefits   accruing   to
participants  under the Plan, if such approval is required in order for the Plan
to comply with the requirements of Rule 16b-3 under the Exchange Act.

         It is expressly  contemplated  that the Board may amend the Plan in any
respect the Board deems  necessary or advisable  to provide  eligible  employers
with the maximum benefits provided or to be provided under the provisions of the
Code and the  regulations  promulgated  thereunder  relating to  employee  stock
purchase  plans  and/or to bring the Plan and/or  rights  granted  under it into
compliance therewith.

         (b) Rights and obligations under any rights granted before amendment of
the Plan shall not be altered or impaired by any  amendment of the Plan,  except
with the consent of the person to whom such rights were granted.

14.     Termination Or Suspension Of The Plan.

         (a) The Board may  suspend or  terminate  the Plan at any time.  Unless
sooner  terminated,  the Plan shall  terminate  ten (10) years from the date the
Plan is adopted by the Board or approved  by the  stockholders  of the  Company,
whichever is earlier.  No rights may be granted under the Plan while the Plan is
suspended or after it is terminated.

         (b) Rights and  obligations  under any rights granted while the Plan is
in effect shall not be altered or impaired by suspension or  termination  of the
Plan, except with the consent of the person to whom such rights were granted.

15.      Effective Date Of Plan.

         The Plan shall become  effective  as  determined  by the Board,  but no
rights  granted under the Plan shall be exercised  unless and until the Plan has
been approved by the vote of the stockholders of the Company,  and, if required,
an appropriate permit has been issued by the Commissioner of Corporations of the
State of California.





                                   EXHIBIT 5

                                                   July 22, 1997

Neurex Corporation
3760 Haven Avenue
Menlo Park, CA  94025

         Re:     Form S-8 Registration Statement;
                 1,400,000 Shares of Common Stock

Ladies and Gentlemen:

         In connection with the registration by Neurex  Corporation,  a Delaware
corporation  (the  "Company"),  of 1,400,000  shares of common stock,  par value
$0.01 per share (the  "Shares"),  of the  Company to be issued  pursuant  to the
Neurex  Corporation  1988 Employee and  Consultant  Stock Option Plan,  and 1997
Employee Stock Purchase Plan,  under the Securities Act of 1933, as amended (the
"Act"), on a Registration  Statement on Form S-8 to be filed with the Securities
and Exchange Commission on or about July 23, 1997 (as amended from time to time,
the  "Registration  Statement"),  you have requested our opinion with respect to
the matters set forth below.

         In our capacity as your counsel in connection  with such  registration,
we are  familiar  with the  proceedings  taken and  proposed  to be taken by the
Company in connection with the  authorization,  issuance and sale of the Shares,
and for the purposes of this  opinion,  have assumed  such  proceedings  will be
timely completed in the manner  presently  proposed.  In addition,  we have made
such legal and factual  examinations and inquiries,  including an examination of
originals or copies  certified or otherwise  identified to our  satisfaction  of
such documents,  corporate records and instruments,  as we have deemed necessary
or appropriate for purposes of this opinion.

         In our examination,  we have assumed the genuineness of all signatures,
the  authenticity  of  all  documents  submitted  to us as  originals,  and  the
conformity to authentic original  documents of all documents  submitted to us as
copies.

         We are opining herein as to the effect on the subject  transaction only
of the General  Corporation  Law of the State of Delaware and the federal law of
the United States,  and we express no opinion with respect to the  applicability
thereto,  or the effect  thereon,  of the laws of any other  jurisdiction or any
other laws, or as to any matters of municipal law or the laws of any other local
agencies within the state.

         Subject  to the  foregoing,  it is our  opinion  that,  as of the  date
hereof,  the Shares have been duly  authorized,  and,  upon the  issuance of and
payment for the Shares in accordance  with the terms set forth in the respective
stock option  plans under which such Shares will be issued and sold,  the Shares
will be validly issued, fully paid and nonassessable.

         We hereby  consent  to your  filing  this  opinion as an exhibit to the
Registration  Statement  and the use of our  name  wherever  it  appears  in the
Registration  Statement.  In giving this consent, we do not hereby admit that we
are in the category of persons whose consent is required  under Section 7 of the
Act.


                                            Very truly yours,


                                            /s/ WISE & SHEPARD LLP
                                            ----------------------------  
                                                WISE & SHEPARD LLP





                                  EXHIBIT 23.2


               CONSENT OF ERNST & YOUNG LLP, INDEPENDENT AUDITORS


         We  consent  to the  incorporation  by  reference  in the  Registration
Statement on Form S-8  pertaining  to the Neurex  Corporation  1988 Employee and
Consultant  Stock Option Plan and the Neurex  Corporation  1997  Employee  Stock
Purchase  Plan of our  report  dated  February  14,  1997,  with  respect to the
consolidated  financial  statements of Neurex Corporation included in its Annual
Report  on Form  10-K for the year  ended  December  31,  1996,  filed  with the
Securities and Exchange Commission.



                                                /s/ Ernst & Young LLP
                                                --------------------------
                                                    Ernst & Young LLP

Palo Alto, California
July 18, 1997




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