METRA BIOSYSTEMS INC
8-K, 1997-01-27
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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                       SECURITIES AND EXCHANGE COMMISSION

                             Washington, D.C. 20549

                                    FORM 8-K

    CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE
                                   ACT OF 1934

                        DATE OF REPORT  January 23, 1997



                            ________________________

                             METRA BIOSYSTEMS, INC.


             (Exact name of registrant as specified in its charter)

                                     0-26234
                            (Commission File Number)

     California                                   33-0408436
     (State or other jurisdiction of              (I.R.S. Employer
     incorporation or organization)               Identification No.)


                             265 North Whisman Road
                             Mountain View, CA 94043
             (Address of principal executive offices, with zip code)


                                 (415) 903-9100
              (Registrant's telephone number, including area code)


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ITEM 5.   OTHER EVENTS

     On January 21, 1997, Metra Biosystems, Inc., a California corporation 
(the "Company") announced that the Board of Directors of the Company approved 
an amendment of the Company's Preferred Shares Rights Agreement (the "Rights 
Agreement") dated as of August 21, 1996 between the Company and The First 
National Bank of Boston to increase the ownership threshold required to 
trigger the Rights Agreement from 15% to 20%.  Further details regarding this 
announcement are contained in the Company's press release dated January 21, 
1997 attached as an exhibit hereto and incorporated by reference herein.

ITEM 7.   FINANCIAL STATEMENTS, PRO FORMA FINANCIAL INFORMATION AND EXHIBITS.

     (c)  EXHIBITS.

     Exhibit 99     Metra Biosystems, Inc. Press Release dated January 21, 1997.


                                      -2-
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                                   SIGNATURES



Pursuant to the requirements of the Securities Exchange Act of 1934, the
registrant has duly caused this report to be signed on its behalf by the
undersigned thereunto duly authorized.


                                       METRA BIOSYSTEMS, INC.



Date:  January 23, 1997                By:  /s/ KURT E. AMUNDSON
                                          ---------------------------------
                                          Kurt E. Amundson
                                          Chief Financial Officer
                                          (Duly Authorized and Principal
                                          Financial and Accounting Officer)


                                      -3-
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                             METRA BIOSYSTEMS, INC.

                                INDEX TO EXHIBITS



Exhibit Number                    Description            Sequential Page Number
- --------------                    -----------            ----------------------


99                 Press Release dated January 21, 1997



                                      -4-



                                       
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                                                        CONTACT:  Kurt Amundson
                                     Vice President and Chief Financial Officer
                                         Metra Biosystems, Inc.  (415) 903-9100

FOR IMMEDIATE RELEASE               THIS PRESS RELEASE CONTAINS FORWARD-LOOKING
                                    STATEMENTS.  SEE THE END OF THIS PRESS
                                    RELEASE FOR  MORE INFORMATION.

                                       
             METRA BIOSYSTEMS, INC. AMENDS SHAREHOLDER RIGHTS PLAN

MOUNTAIN VIEW, CA -- JANUARY 21, 1997 --Metra Biosystems, Inc. (Nasdaq: MTRA) 
announced today an amendment to its shareholder rights plan raising the 
percentage ownership to 20% that any entity could accumulate without 
triggering the shareholder rights plan.  Previous to this change the trigger 
was 15%.

"Upon the advice of our legal and financial advisors, and upon analysis of 
the Company's institutional shareholder base, the Board of Directors of Metra 
concluded that this change was in the best interests of Metra and its 
shareholders," stated George Dunbar, president and chief executive officer.

Metra Biosystems, Inc. is a leader in developing and commercializing 
diagnostic products for the detection and management of metabolic bone 
diseases and disorders.  The Company's strategy is to offer a portfolio of 
diagnostic products that will provide physicians with comprehensive clinical 
information regarding the metabolism of bone and other connective tissues.  
The Company has developed and is currently marketing for either research use 
or clinical use: two immunodiagnostic tests to assess bone resorption; two 
immunodiagnostic tests to assess bone formation and one immunodiagnostic test 
to assess bone growth disorders.  In addition, the Company is developing a 
portable ultrasound device designed to assess bone fragility and biochemical 
markers to detect cartilage disorders.

THE MATTERS CONTAINED IN THIS NEWS RELEASE, EXCEPT FOR THE HISTORICAL 
INFORMATION SET FORTH HEREIN, ARE FORWARD-LOOKING STATEMENTS THAT ARE 
DEPENDENT ON CERTAIN RISKS AND UNCERTAINTIES INCLUDING SUCH FACTORS, AMONG 
OTHERS, AS THE UNCERTAINTY OF MARKET ACCEPTANCE FOR BIOCHEMICAL MARKERS, 
METRA'S DEPENDENCE UPON INTERNATIONAL SALES, THE UNCERTAINTY OF INTERNATIONAL 
REGULATIONS, METRA'S RELIANCE UPON COLLABORATIVE RELATIONSHIPS, THE 
UNCERTAINTY OF ULTRASOUND TECHNOLOGY DEVELOPMENT, COMPETITION AND REGULATION 
AND THE OTHER RISK FACTORS LISTED IN THE COMPANY'S PROSPECTUS DATED APRIL 23, 
1996, THE COMPANY'S ANNUAL REPORT ON FORM 10-K FOR THE FISCAL YEAR

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ENDED JUNE 30, 1996, AND IN THE COMPANY'S PERIODIC REPORTS ON FORM 10-Q AND 
IN OTHER FILINGS WITH THE SEC.

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