We consent to the reference to our firm under the caption "Experts" in the Amendment No. 1 to the Registration Statement on Form S-3 (Registration No. 333-45706) and related Prospectus of Integrated Surgical Systems, Inc. for the registration of 12,758,209 shares of its common stock and to the incorporation by reference therein of our report dated March 10, 2000, with respect to the consolidated financial statements of Integrated Surgical Systems, Inc. included in its Annual Report (Form 10-KSB and Form 10-KSB/A (Amendment No. 1)), for the year ended December 31, 1999 filed with the Securities and Exchange Commission.

ERNST & YOUNG LLP

Sacramento, California

September 25, 2000